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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BRIP1-SPAG9 (FusionGDB2 ID:HG83990TG9043)

Fusion Gene Summary for BRIP1-SPAG9

check button Fusion gene summary
Fusion gene informationFusion gene name: BRIP1-SPAG9
Fusion gene ID: hg83990tg9043
HgeneTgene
Gene symbol

BRIP1

SPAG9

Gene ID

83990

9043

Gene nameBRCA1 interacting protein C-terminal helicase 1sperm associated antigen 9
SynonymsBACH1|FANCJ|OFCT89|HLC-6|HLC4|HLC6|JIP-4|JIP4|JLP|PHET|PIG6
Cytomap('BRIP1')('SPAG9')

17q23.2

17q21.33

Type of geneprotein-codingprotein-coding
DescriptionFanconi anemia group J proteinATP-dependent RNA helicase BRIP1BRCA1-associated C-terminal helicase 1BRCA1-binding helicase-like protein BACH1BRCA1/BRCA2-associated helicase 1C-Jun-amino-terminal kinase-interacting protein 4JNK interacting proteinJNK/SAPK-associated proteinMax-binding proteinc-Jun NH2-terminal kinase-associated leucine zipper proteincancer/testis antigen 89human lung cancer oncogene 6 proteinlung cancer
Modification date2020031520200315
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000259008, ENST00000577598, 
ENST00000583837, 		ENST00000583837, 
ENST00000259008, ENST00000577598, 
Fusion gene scores* DoF score3 X 4 X 1=1215 X 14 X 6=1260
# samples 416
** MAII scorelog2(4/12*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(16/1260*10)=-2.97727992349992
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BRIP1 [Title/Abstract] AND SPAG9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBRIP1(59934419)-SPAG9(49157065), # samples:2
Anticipated loss of major functional domain due to fusion event.BRIP1-SPAG9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BRIP1-SPAG9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BRIP1-SPAG9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BRIP1-SPAG9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SPAG9-BRIP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SPAG9-BRIP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BRIP1-SPAG9 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
BRIP1-SPAG9 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
BRIP1-SPAG9 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
SPAG9-BRIP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SPAG9-BRIP1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
SPAG9-BRIP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBRIP1

GO:0006357

regulation of transcription by RNA polymerase II

14504288

TgeneSPAG9

GO:0042147

retrograde transport, endosome to Golgi

19056739


check buttonFusion gene breakpoints across BRIP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SPAG9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A0TQ-01ABRIP1chr17

59934419

-SPAG9chr17

49157065

-
ChimerDB4BRCATCGA-AR-A0TQBRIP1chr17

59934418

-SPAG9chr17

49157065

-


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Fusion Gene ORF analysis for BRIP1-SPAG9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000259008ENST00000509724BRIP1chr17

59934419

-SPAG9chr17

49157065

-
5CDS-intronENST00000259008ENST00000509724BRIP1chr17

59934418

-SPAG9chr17

49157065

-
5CDS-intronENST00000259008ENST00000510283BRIP1chr17

59934419

-SPAG9chr17

49157065

-
5CDS-intronENST00000259008ENST00000510283BRIP1chr17

59934418

-SPAG9chr17

49157065

-
5CDS-intronENST00000577598ENST00000509724BRIP1chr17

59934419

-SPAG9chr17

49157065

-
5CDS-intronENST00000577598ENST00000509724BRIP1chr17

59934418

-SPAG9chr17

49157065

-
5CDS-intronENST00000577598ENST00000510283BRIP1chr17

59934419

-SPAG9chr17

49157065

-
5CDS-intronENST00000577598ENST00000510283BRIP1chr17

59934418

-SPAG9chr17

49157065

-
Frame-shiftENST00000577598ENST00000262013BRIP1chr17

59934419

-SPAG9chr17

49157065

-
Frame-shiftENST00000577598ENST00000262013BRIP1chr17

59934418

-SPAG9chr17

49157065

-
Frame-shiftENST00000577598ENST00000357122BRIP1chr17

59934419

-SPAG9chr17

49157065

-
Frame-shiftENST00000577598ENST00000357122BRIP1chr17

59934418

-SPAG9chr17

49157065

-
Frame-shiftENST00000577598ENST00000505279BRIP1chr17

59934419

-SPAG9chr17

49157065

-
Frame-shiftENST00000577598ENST00000505279BRIP1chr17

59934418

-SPAG9chr17

49157065

-
In-frameENST00000259008ENST00000262013BRIP1chr17

59934419

-SPAG9chr17

49157065

-
In-frameENST00000259008ENST00000262013BRIP1chr17

59934418

-SPAG9chr17

49157065

-
In-frameENST00000259008ENST00000357122BRIP1chr17

59934419

-SPAG9chr17

49157065

-
In-frameENST00000259008ENST00000357122BRIP1chr17

59934418

-SPAG9chr17

49157065

-
In-frameENST00000259008ENST00000505279BRIP1chr17

59934419

-SPAG9chr17

49157065

-
In-frameENST00000259008ENST00000505279BRIP1chr17

59934418

-SPAG9chr17

49157065

-
intron-3CDSENST00000583837ENST00000262013BRIP1chr17

59934419

-SPAG9chr17

49157065

-
intron-3CDSENST00000583837ENST00000262013BRIP1chr17

59934418

-SPAG9chr17

49157065

-
intron-3CDSENST00000583837ENST00000357122BRIP1chr17

59934419

-SPAG9chr17

49157065

-
intron-3CDSENST00000583837ENST00000357122BRIP1chr17

59934418

-SPAG9chr17

49157065

-
intron-3CDSENST00000583837ENST00000505279BRIP1chr17

59934419

-SPAG9chr17

49157065

-
intron-3CDSENST00000583837ENST00000505279BRIP1chr17

59934418

-SPAG9chr17

49157065

-
intron-intronENST00000583837ENST00000509724BRIP1chr17

59934419

-SPAG9chr17

49157065

-
intron-intronENST00000583837ENST00000509724BRIP1chr17

59934418

-SPAG9chr17

49157065

-
intron-intronENST00000583837ENST00000510283BRIP1chr17

59934419

-SPAG9chr17

49157065

-
intron-intronENST00000583837ENST00000510283BRIP1chr17

59934418

-SPAG9chr17

49157065

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000259008BRIP1chr1759934419-ENST00000262013SPAG9chr1749157065-840864761443091231
ENST00000259008BRIP1chr1759934419-ENST00000505279SPAG9chr1749157065-492564761442791221
ENST00000259008BRIP1chr1759934419-ENST00000357122SPAG9chr1749157065-489664761442671217
ENST00000259008BRIP1chr1759934418-ENST00000262013SPAG9chr1749157065-840864761443091231
ENST00000259008BRIP1chr1759934418-ENST00000505279SPAG9chr1749157065-492564761442791221
ENST00000259008BRIP1chr1759934418-ENST00000357122SPAG9chr1749157065-489664761442671217

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000259008ENST00000262013BRIP1chr1759934419-SPAG9chr1749157065-0.0001564920.9998435
ENST00000259008ENST00000505279BRIP1chr1759934419-SPAG9chr1749157065-0.0008877030.9991123
ENST00000259008ENST00000357122BRIP1chr1759934419-SPAG9chr1749157065-0.0003722210.9996277
ENST00000259008ENST00000262013BRIP1chr1759934418-SPAG9chr1749157065-0.0001564920.9998435
ENST00000259008ENST00000505279BRIP1chr1759934418-SPAG9chr1749157065-0.0008877030.9991123
ENST00000259008ENST00000357122BRIP1chr1759934418-SPAG9chr1749157065-0.0003722210.9996277

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Fusion Genomic Features for BRIP1-SPAG9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for BRIP1-SPAG9


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:59934419/chr17:49157065)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSPAG9chr17:59934418chr17:49157065ENST00000262013030408_5341011322.0Coiled coilOntology_term=ECO:0000269
TgeneSPAG9chr17:59934418chr17:49157065ENST00000262013030724_7581011322.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG9chr17:59934418chr17:49157065ENST00000357122029408_5341011308.0Coiled coilOntology_term=ECO:0000269
TgeneSPAG9chr17:59934418chr17:49157065ENST00000357122029724_7581011308.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG9chr17:59934418chr17:49157065ENST00000505279030408_5341011312.0Coiled coilOntology_term=ECO:0000269
TgeneSPAG9chr17:59934418chr17:49157065ENST00000505279030724_7581011312.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG9chr17:59934418chr17:49157065ENST00000510283027408_53401178.0Coiled coilOntology_term=ECO:0000269
TgeneSPAG9chr17:59934418chr17:49157065ENST0000051028302766_16601178.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG9chr17:59934418chr17:49157065ENST00000510283027724_75801178.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG9chr17:59934419chr17:49157065ENST00000262013030408_5341011322.0Coiled coilOntology_term=ECO:0000269
TgeneSPAG9chr17:59934419chr17:49157065ENST00000262013030724_7581011322.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG9chr17:59934419chr17:49157065ENST00000357122029408_5341011308.0Coiled coilOntology_term=ECO:0000269
TgeneSPAG9chr17:59934419chr17:49157065ENST00000357122029724_7581011308.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG9chr17:59934419chr17:49157065ENST00000505279030408_5341011312.0Coiled coilOntology_term=ECO:0000269
TgeneSPAG9chr17:59934419chr17:49157065ENST00000505279030724_7581011312.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG9chr17:59934419chr17:49157065ENST00000510283027408_53401178.0Coiled coilOntology_term=ECO:0000269
TgeneSPAG9chr17:59934419chr17:49157065ENST0000051028302766_16601178.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG9chr17:59934419chr17:49157065ENST00000510283027724_75801178.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG9chr17:59934418chr17:49157065ENST00000262013030500_5711011322.0DomainRH2
TgeneSPAG9chr17:59934418chr17:49157065ENST00000357122029500_5711011308.0DomainRH2
TgeneSPAG9chr17:59934418chr17:49157065ENST00000505279030500_5711011312.0DomainRH2
TgeneSPAG9chr17:59934418chr17:49157065ENST00000510283027500_57101178.0DomainRH2
TgeneSPAG9chr17:59934418chr17:49157065ENST000005102830277_9501178.0DomainRH1
TgeneSPAG9chr17:59934419chr17:49157065ENST00000262013030500_5711011322.0DomainRH2
TgeneSPAG9chr17:59934419chr17:49157065ENST00000357122029500_5711011308.0DomainRH2
TgeneSPAG9chr17:59934419chr17:49157065ENST00000505279030500_5711011312.0DomainRH2
TgeneSPAG9chr17:59934419chr17:49157065ENST00000510283027500_57101178.0DomainRH2
TgeneSPAG9chr17:59934419chr17:49157065ENST000005102830277_9501178.0DomainRH1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRIP1chr17:59934418chr17:49157065ENST00000259008-42011_4421261250.0DomainHelicase ATP-binding
HgeneBRIP1chr17:59934419chr17:49157065ENST00000259008-42011_4421261250.0DomainHelicase ATP-binding
HgeneBRIP1chr17:59934418chr17:49157065ENST00000259008-420158_1751261250.0MotifNuclear localization signal
HgeneBRIP1chr17:59934418chr17:49157065ENST00000259008-420393_3961261250.0MotifNote=DEAH box
HgeneBRIP1chr17:59934419chr17:49157065ENST00000259008-420158_1751261250.0MotifNuclear localization signal
HgeneBRIP1chr17:59934419chr17:49157065ENST00000259008-420393_3961261250.0MotifNote=DEAH box
HgeneBRIP1chr17:59934418chr17:49157065ENST00000259008-420185_1921261250.0Nucleotide bindingATP
HgeneBRIP1chr17:59934419chr17:49157065ENST00000259008-420185_1921261250.0Nucleotide bindingATP
TgeneSPAG9chr17:59934418chr17:49157065ENST0000026201303066_1661011322.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG9chr17:59934418chr17:49157065ENST0000035712202966_1661011308.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG9chr17:59934418chr17:49157065ENST0000050527903066_1661011312.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG9chr17:59934419chr17:49157065ENST0000026201303066_1661011322.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG9chr17:59934419chr17:49157065ENST0000035712202966_1661011308.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG9chr17:59934419chr17:49157065ENST0000050527903066_1661011312.0Coiled coilOntology_term=ECO:0000255
TgeneSPAG9chr17:59934418chr17:49157065ENST000002620130307_951011322.0DomainRH1
TgeneSPAG9chr17:59934418chr17:49157065ENST000003571220297_951011308.0DomainRH1
TgeneSPAG9chr17:59934418chr17:49157065ENST000005052790307_951011312.0DomainRH1
TgeneSPAG9chr17:59934419chr17:49157065ENST000002620130307_951011322.0DomainRH1
TgeneSPAG9chr17:59934419chr17:49157065ENST000003571220297_951011308.0DomainRH1
TgeneSPAG9chr17:59934419chr17:49157065ENST000005052790307_951011312.0DomainRH1


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Fusion Gene Sequence for BRIP1-SPAG9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10289_10289_1_BRIP1-SPAG9_BRIP1_chr17_59934418_ENST00000259008_SPAG9_chr17_49157065_ENST00000262013_length(transcript)=8408nt_BP=647nt
AATTCGTCTCGGGTTGTGTGGTTGAGGGGTCTGGTGGGTCGAGGAAAGGTAACGGCGGCCCCAGTCCTGCACACAAGGCCGGGGAAGTAG
CAGCACCCCCAGGAAGAGGGAGGAGGAAGGGCTCGTGCCCTTTCTTCTCTTCCAGGGCTCCGCTTTATTTGCTCTCAGAAGTCGGTTTCC
TTTCCTTTTCTTCAGTGAATCGGAGCTCAGAGCGTTGCTTCGGTTTCCCTCCAGACAGTTAGGAATCTGAAATAAACAGGAAAGCACTAT
GTCTTCAATGTGGTCTGAATATACAATTGGTGGGGTGAAGATTTACTTTCCTTATAAAGCTTACCCGTCACAGCTTGCTATGATGAATTC
TATTCTCAGAGGATTAAACAGCAAGCAACATTGTTTGTTGGAGAGTCCCACAGGAAGTGGAAAAAGCTTAGCCTTACTTTGTTCTGCTTT
AGCATGGCAACAATCTCTTAGTGGGAAACCAGCAGATGAGGGCGTAAGTGAAAAAGCTGAAGTACAATTGTCATGTTGTTGTGCATGCCA
TTCAAAGGATTTTACAAACAATGACATGAACCAAGGAACTTCACGTCATTTCAACTATCCAAGCACACCACCTTCTGAAAGAAATGGCAC
TTCATCAACTTGTCAAGAAATTCATTGAATTTGAAGACTCTCAAGAACAGGAAAAAAAGGACTTACAGACCCGAGTGGAATCTTTAGAAT
CTCAAACAAGACAACTTGAGCTGAAAGCGAAAAACTATGCTGACCAGATTAGCAGACTTGAAGAAAGAGAAGCAGAACTGAAGAAGGAAT
ATAATGCATTACATCAAAGACACACTGAGATGATCCATAATTATATGGAACATTTAGAAAGAACAAAACTTCATCAGCTCTCAGGGAGTG
ATCAACTAGAATCCACAGCTCATAGTAGAATTAGAAAAGAACGCCCTATATCATTAGGAATTTTCCCATTACCTGCTGGAGATGGATTGC
TTACACCTGATGCTCAGAAAGGAGGAGAGACCCCTGGATCTGAGCAATGGAAATTTCAGGAATTAAGTCAACCACGTTCTCATACCAGCC
TGAAGGTCAGCAATAGTCCTGAACCTCAGAAGGCTGTAGAACAGGAGGATGAGCTTTCTGATGTTAGCCAAGGCGGATCTAAAGCTACCA
CTCCAGCATCAACAGCTAATTCAGATGTGGCAACAATTCCTACTGATACTCCCTTAAAGGAAGAAAACGAAGGATTTGTGAAGGTTACAG
ATGCGCCAAATAAATCAGAGATAAGCAAACACATTGAAGTACAGGTAGCCCAGGAAACTAGAAATGTATCTACTGGCTCTGCTGAAAATG
AAGAAAAGTCAGAAGTTCAAGCAATCATCGAATCTACTCCTGAGCTGGATATGGACAAAGATCTCAGTGGATATAAAGGTTCAAGCACTC
CCACCAAAGGCATAGAGAACAAAGCTTTTGATCGCAATACAGAATCTCTCTTTGAAGAACTGTCTTCAGCTGGCTCAGGCCTAATAGGAG
ATGTGGATGAAGGAGCAGATTTACTAGGAATGGGTCGGGAAGTTGAGAATCTTATATTAGAAAATACACAACTGTTGGAAACCAAAAATG
CTTTGAACATAGTGAAGAATGATTTGATAGCAAAAGTGGATGAACTGACCTGTGAGAAAGATGTGCTGCAAGGGGAATTGGAGGCTGTGA
AGCAAGCCAAACTGAAACTAGAGGAAAAGAACAGAGAATTGGAGGAAGAGCTTAGGAAAGCTCGGGCAGAAGCTGAAGATGCAAGGCAAA
AAGCAAAAGATGACGATGATAGTGATATTCCCACAGCCCAGAGGAAACGGTTTACTAGAGTAGAAATGGCCCGTGTTCTCATGGAGCGAA
ACCAGTATAAAGAGAGATTGATGGAGCTTCAGGAAGCTGTTCGATGGACAGAGATGATTCGGGCATCACGAGAAAATCCAGCCATGCAGG
AAAAAAAAAGGTCAAGCATTTGGCAGTTTTTCAGCCGACTTTTCAGCTCCTCAAGTAACACGACTAAGAAGCCTGAACCACCTGTTAATC
TGAAGTACAATGCACCCACGTCTCATGTTACTCCGTCCGTCAAGAAAAGAAGCAGCACCTTATCTCAGCTCCCTGGGGATAAGTCCAAAG
CCTTTGATTTCCTTAGTGAAGAAACTGAAGCTAGTTTAGCCTCACGCAGAGAACAAAAGAGAGAGCAGTATCGTCAGGTAAAAGCACATG
TTCAGAAGGAAGACGGTAGAGTGCAGGCTTTTGGCTGGAGTCTGCCTCAGAAGTACAAACAGGTAACCAATGGTCAAGGTGAAAATAAGA
TGAAAAATTTACCTGTGCCTGTCTATCTCAGACCTCTGGATGAAAAAGATACATCAATGAAGCTGTGGTGTGCTGTTGGAGTCAATTTAT
CTGGTGGGAAGACCAGAGATGGTGGTTCTGTTGTTGGAGCAAGTGTATTTTACAAGGATGTTGCTGGTTTGGATACAGAAGGCAGTAAAC
AGCGAAGTGCCTCTCAGAGTAGTTTAGATAAGTTAGATCAGGAACTTAAGGAACAGCAGAAGGAGTTAAAAAATCAAGAAGAATTATCCA
GTCTAGTTTGGATCTGTACCAGCACTCATTCGGCTACAAAAGTTCTTATTATTGATGCTGTTCAACCTGGCAACATCCTAGACAGTTTCA
CTGTTTGCAACTCTCATGTTCTGTGCATTGCAAGTGTGCCAGGTGCACGAGAAACAGACTACCCTGCAGGAGAAGATCTTTCAGAATCTG
GTCAGGTAGACAAAGCATCTTTATGTGGAAGTATGACAAGCAACAGCTCAGCAGAGACAGACAGCCTGTTAGGAGGCATCACAGTGGTTG
GTTGTTCTGCAGAAGGTGTGACGGGAGCTGCCACTTCCCCTAGTACAAATGGTGCTTCTCCAGTGATGGATAAACCACCAGAAATGGAAG
CAGAAAATAGTGAGGTTGATGAAAATGTTCCAACAGCAGAAGAAGCAACTGAAGCTACAGAAGGGAATGCGGGGTCAGCTGAAGACACAG
TGGACATCTCCCAAACTGGCGTCTACACAGAGCATGTCTTTACAGATCCTTTGGGAGTTCAGATCCCAGAAGACCTCTCCCCAGTGTATC
AGTCGAGCAATGACTCAGATGCATATAAAGATCAAATATCAGTACTGCCAAATGAACAAGACTTGGTGAGAGAAGAAGCCCAGAAAATGA
GTAGTCTTTTACCAACTATGTGGCTTGGAGCTCAAAATGGCTGTTTGTATGTCCATTCATCTGTAGCCCAGTGGAGGAAATGTCTCCATT
CCATTAAACTTAAAGATTCGATTCTCAGTATTGTACACGTGAAGGGAATCGTGTTAGTAGCCCTGGCTGACGGCACCCTTGCAATCTTTC
ACAGAGGAGTGGATGGGCAGTGGGATTTGTCAAACTATCACCTCTTAGACCTTGGACGGCCTCATCATTCCATCCGTTGCATGACTGTGG
TACATGACAAAGTCTGGTGTGGCTATAGGAACAAAATCTATGTGGTGCAGCCAAAGGCCATGAAAATAGAGAAATCTTTTGATGCACATC
CCAGGAAGGAGAGCCAAGTGCGACAGCTTGCGTGGGTGGGGGATGGCGTGTGGGTCTCCATTCGCTTGGATTCTACGCTCCGTCTCTATC
ATGCACACACTTATCAACATCTACAGGATGTGGACATTGAGCCTTATGTAAGCAAAATGTTAGGTACTGGAAAACTGGGCTTCTCTTTTG
TGAGAATTACAGCTCTTATGGTGTCTTGTAATCGTTTGTGGGTGGGGACAGGAAATGGTGTCATTATCTCCATCCCATTGACAGAAACAA
ATAAAACCTCAGGTGTACCAGGAAATCGTCCTGGAAGTGTAATCCGTGTATATGGTGATGAAAACAGTGATAAAGTGACTCCAGGGACAT
TTATACCCTATTGTTCAATGGCACATGCACAGCTTTGCTTCCATGGGCACCGGGATGCTGTGAAATTCTTTGTGGCAGTCCCAGGTCAAG
TCATCAGCCCACAAAGTAGCAGTAGTGGCACGGATCTGACGGGTGACAAAGCAGGGCCATCTGCACAGGAGCCTGGTAGTCAGACGCCCT
TGAAGTCTATGCTTGTCATCAGTGGAGGAGAGGGCTACATCGACTTCCGAATGGGTGATGAAGGTGGAGAATCAGAACTTCTTGGAGAGG
ATCTTCCACTTGAACCTTCTGTCACCAAAGCAGAAAGGAGTCACTTGATAGTGTGGCAAGTGATGTATGGCAATGAGTGAGCCCATGGGA
AACAGGTGGAGATGGGGAAGCCGTCTCTTCTGCATGGTTTATTTTCCCTCTATCCTTTTATTTAATGCTCTTTTGTGAGATAAGTTTCAC
CACATAATGTGTGAGCATTTTTTCCTGTTAACTTTATATTACAAAATCCGTTCTACCATAACAATACAGAGGAACTAGCTGTGTTACTGC
ACCAGTGTTATAGGTAACTTCAGTATATTATGAACAAATCAAAGAATGTTTACTTCCTGCAAACTGGTGAATTATAGAAAGCAATCCAGA
TGTGGTTTACTCTGCCACAGTCTAATGTCATTCACTTCATTTGATGGGGTCACTTGTTAGCTGTCACTAATAATGGAATTAATGGGAAAC
ACTTGATAAATGAAACTGTACCGTTAAATACAATAGCTGAGTTTTCCCCAGTGTATTGTAAAATTGACACACACTAATACAAGATGGATT
ATCAGGATGTATCTAAATGTCCCGAGAGGGTTAAAAGCTAACTGTAAATTACTTTAACTTTCACTTTCAAATCTGACAAATCTTGTTTAT
ATGGTATATAAAACTTTGTTTTCATCAGATTTGGGGGGGTTTTATATTAAAGAAATTAAGACTACACTATTTAAATAAACGTTTCCTGTT
TCTGACTTATTAGAGCTCTAAAGTTTATGAGGCCTACTTCTCTGAATATTCTGATGGGTTTTTTTTGAGACCAGTCTCATTTTCATACTG
ACATGTCTGAAAGATTTATTATTTATAAAGCTTAGGACATACTCTGGGAAGCTTAGAAGATACTTCAGCACTGGGAGGATTTTTTAAAGG
AAATGTGTTTTGTATTTCTTGTACCAGAGAATGGTGATGTTGATTGAGTTTTTTCCATGTAAAAAATGTACTTGTTTGCCAAATGTTCCT
AGATTGCTCTTAACCTGTTAATACAAGTAAAACTGTAGTGGGGATGGAGTCTGGCCTAAGTACAGAATGAGGGATTTAATTAGAAAAGTT
ATTTTCTTTTGTTCTGTATCAAACTGCAGAACAGCTATATACTTGGTATTTTGTACGTGAATAACGTTTTAGCTTTTGTGCCCTTTTGAG
CTTGAAGGGTTATCCTCAAAGGGGAAAACTATGAAGGGGAAGAAGACAAACCTAAGATACCATAAAGTAAAGGTTGACATTACATATTTT
CATTCACAATGCCCATTAAAAAAAAAAAATAGGTTGGGCATGGTGGCTCACGCCTGTAATCCCAACACTTTAGGAGGCTGAGGCAGATGG
ATTGCTTGAGCCCAGGAGTTCAAGACCAGCCTGGGCAACATGGCGAAACCCTGTCTCTACCAAAAAAAAAAAACAAAATAAATTAACCGG
GTGTGGTGGCACATGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGTGGGAGGATGACCTGGGCCCAGGAGGTGGAGGTTGCAGTGAGCC
TTGATAGCACCACTGCACTCCAGCCTGGGTGACGGAGCAAGACCCTGTCTCAAAACAGACAAACAAGCAAAAAATAGATTAAAGTCTGGA
TTTCACTGATTTTCTTGCTTAATAAGTTTTTTAAAACCACGATGCTGCAATTTTTTCCCTCTCAAGCTTCTTGAAAATGTGTGATTTACC
CTTTTTTATCTATTACTCTAGGCAAAGCTAAATATGATTTTTTTTTTTTTTTTTGAGACGGAGTCTGGCTCTGTTGCCCAGGCTGGAATG
CAGTGGTGCGATCTCAGCTCACTGCAACCTCCACCTCTCAGGTTCAAGTAGTTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGG
TGTGTGCCACCCTGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCACATTGGCCAGGCTGGTCTCAAACTCCTGACCTC
AGATGATCTACCCGCCTTGGCCTCCCGAAGTGCTTGAATTACAGGCGTGAGCCCCCGCGCCGGTCCGAAGCAAAGCTAAATGTAATTTTA
TGTACTGTTTTAACAGTATAAACCTATGGGATAAAGGCCCCCAATCATCAGAAGGACTACTGAAAAGAAAAGAAAGCAAACGTAGATGTC
AAATTGTCTAAACATTCTTAAGTACCACTGATTTTTTTTTTCTGGACTATTATACAAAGATGTCTGTAAAAAGTATACCAGTGGCTTTTA
TGCATATACACGATTAGGCTAGATTGTGAAGTACATGGGATTTCATGAGCCAGAGGAGGCATTTGGATCCATTGGGCCACATGTGACTAT
AAGCACATTGTGTACACAATAAAATTGTAGCCACTCATGTATTAAAACTGTTTTGGTAAAAGCTGTATTAAAAGAATAATTTTTTGCTTG
AGCTACTTAGTCACTTTTTTGCAGGGCACCAAAATGTAGGCTACTTTTCCATAGCTTGTTTGCTATGTTTTTATTTCATCTTAAATCTGA
GCCATTTTTGGCAATATCTTTTAAAAAATCATTATTAAACATTTATTGGAAATGTTGTATAGATTCACAAGAAAGAGACACCAAAGTGTT
TGGGAATTTTAATCCCAAGAAGTAAACATCCCAGAGTCAGATCCCATTTGCTGTTGTTCAGCCATGTTTGTATGACTGAATGTAATTTAG
GAAATCAGGAGTTAGAGATGAAAAATACAAACATGTCAAATGGTTGTAATTGCTTTTTTTGAACTTACTGGCTTTAACTTAAGTAATATA
GGTGTGTAGTTGTTTTATCTAAAGATGTCAGATTATCTGTGGCCCTGTTAATTAACTGCAGGGACCAGAGAGAGGACAAAAATGCCTGTA
TAATTTGCTTTAAAGGCTTGTCCTTATGTTTGTAATTTCAGTTAAATATTTTCTACAGATTGCTTCACTTCCCCTTTCCCCCAATAACAA
GTTCATATTCTTGTAATGTTTACTTTGGTCAACGTGGTAATTTTTGGAAGAAAATGCCAAAATGTAAGCTTCTCACAAGCAGCAAAGGAA
TGTAACTGCCTGTAGCTACCACATCAAGGGAGAGAAGAGGCTTGCGTACTTTGGGTTGATCTCACTGTACAAAAAAAGTGTACCCCTATT
GGAAGAAATAAGGAATACTTGAAGGTTTCTCCTTTTTTTACACTTGAGTCATGTGCAAGGTTGAACCATATGAAATTGCCAGTGTTCAAC
CATTGCTGATCTGCAAAAGCGACAATATCATATGCCTCAACCTAACACTTACTCTTAAATGCAGGTTAAAATCTCTGTGAGGCAAAGGGA
TAATATTCTCTAGGAACTCACTTTTGAGAGTATTTTTCTCTAACCCATGTGGATCTAAATTTTAAAAATAGGAATGAATCTCTTAATTGC
AGCTTGTGGAGAGTATAAAACATTTTGAGCACAATATGCAGCACATAACTTTTCAGATTGTGTTTGCATAGAAAAGGTTAAAATCAATTC
TTTCAGTTACTGTATTGTTCATTTCTTGTAAAGGTCTTCCTACATTTGAGACGAGACCCTTTAACATAGGCTGCCTTAGTAACAAAATAA
AACAGATGTGTCATAATATTAACTGTCCTAAAGAACATGTGTCTTGCAAATGCCATGGAACTGAATATTTATTTCCTTGTGAGTATTATG
ACCGTTACCAAAGGACTCAACCAGATTTAGGGCTCTTCTTAATTGATCATGTTCAGAAAGGGACTCATTTGGTCCCACTTTGTAACATGG
GAAGAGTAGAAGAGAAAATTAAATGTGGAAATCATAAATGCTTTTCTAACAGGGTTATGCTATTCTGTAACACTAAATGTCTGTCTTTTC
TCTTAAAAGATTAAGTTTTATTAATTTTGTCATACATTTCTCTATTTGAATATATCTTAACCATTTTATGTTCCAAATTCGTTTTTTGTC
CAAGACATTCTATCAGAATTTTACTTGCCTCTATAATCTGAAAAATGGGTTCTAGAATGTCCCACTTGCTGTCTCTTAGAGGCTGAGCTT
CATTTCTATGAGCAAAGAGCTCATTTAGCAATGTAGTTATTTCAGTATTTATTTCTATTATGGAATCCCTGGGGTTCAGAATGTAACTTT

>10289_10289_1_BRIP1-SPAG9_BRIP1_chr17_59934418_ENST00000259008_SPAG9_chr17_49157065_ENST00000262013_length(amino acids)=1231AA_BP=11
MKEMALHQLVKKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH
QLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQEDELSDVSQG
GSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGY
KGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQG
ELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRE
NPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYR
QVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLD
TEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLVWICTSTHSATKVLIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGE
DLSESGQVDKASLCGSMTSNSSAETDSLLGGITVVGCSAEGVTGAATSPSTNGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAG
SAEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVLPNEQDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQW
RKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEK
SFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISI
PLTETNKTSGVPGNRPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEP

--------------------------------------------------------------
>10289_10289_2_BRIP1-SPAG9_BRIP1_chr17_59934418_ENST00000259008_SPAG9_chr17_49157065_ENST00000357122_length(transcript)=4896nt_BP=647nt
AATTCGTCTCGGGTTGTGTGGTTGAGGGGTCTGGTGGGTCGAGGAAAGGTAACGGCGGCCCCAGTCCTGCACACAAGGCCGGGGAAGTAG
CAGCACCCCCAGGAAGAGGGAGGAGGAAGGGCTCGTGCCCTTTCTTCTCTTCCAGGGCTCCGCTTTATTTGCTCTCAGAAGTCGGTTTCC
TTTCCTTTTCTTCAGTGAATCGGAGCTCAGAGCGTTGCTTCGGTTTCCCTCCAGACAGTTAGGAATCTGAAATAAACAGGAAAGCACTAT
GTCTTCAATGTGGTCTGAATATACAATTGGTGGGGTGAAGATTTACTTTCCTTATAAAGCTTACCCGTCACAGCTTGCTATGATGAATTC
TATTCTCAGAGGATTAAACAGCAAGCAACATTGTTTGTTGGAGAGTCCCACAGGAAGTGGAAAAAGCTTAGCCTTACTTTGTTCTGCTTT
AGCATGGCAACAATCTCTTAGTGGGAAACCAGCAGATGAGGGCGTAAGTGAAAAAGCTGAAGTACAATTGTCATGTTGTTGTGCATGCCA
TTCAAAGGATTTTACAAACAATGACATGAACCAAGGAACTTCACGTCATTTCAACTATCCAAGCACACCACCTTCTGAAAGAAATGGCAC
TTCATCAACTTGTCAAGAAATTCATTGAATTTGAAGACTCTCAAGAACAGGAAAAAAAGGACTTACAGACCCGAGTGGAATCTTTAGAAT
CTCAAACAAGACAACTTGAGCTGAAAGCGAAAAACTATGCTGACCAGATTAGCAGACTTGAAGAAAGAGAAGCAGAACTGAAGAAGGAAT
ATAATGCATTACATCAAAGACACACTGAGATGATCCATAATTATATGGAACATTTAGAAAGAACAAAACTTCATCAGCTCTCAGGGAGTG
ATCAACTAGAATCCACAGCTCATAGTAGAATTAGAAAAGAACGCCCTATATCATTAGGAATTTTCCCATTACCTGCTGGAGATGGATTGC
TTACACCTGATGCTCAGAAAGGAGGAGAGACCCCTGGATCTGAGCAATGGAAATTTCAGGAATTAAGTCAACCACGTTCTCATACCAGCC
TGAAGGATGAGCTTTCTGATGTTAGCCAAGGCGGATCTAAAGCTACCACTCCAGCATCAACAGCTAATTCAGATGTGGCAACAATTCCTA
CTGATACTCCCTTAAAGGAAGAAAACGAAGGATTTGTGAAGGTTACAGATGCGCCAAATAAATCAGAGATAAGCAAACACATTGAAGTAC
AGGTAGCCCAGGAAACTAGAAATGTATCTACTGGCTCTGCTGAAAATGAAGAAAAGTCAGAAGTTCAAGCAATCATCGAATCTACTCCTG
AGCTGGATATGGACAAAGATCTCAGTGGATATAAAGGTTCAAGCACTCCCACCAAAGGCATAGAGAACAAAGCTTTTGATCGCAATACAG
AATCTCTCTTTGAAGAACTGTCTTCAGCTGGCTCAGGCCTAATAGGAGATGTGGATGAAGGAGCAGATTTACTAGGAATGGGTCGGGAAG
TTGAGAATCTTATATTAGAAAATACACAACTGTTGGAAACCAAAAATGCTTTGAACATAGTGAAGAATGATTTGATAGCAAAAGTGGATG
AACTGACCTGTGAGAAAGATGTGCTGCAAGGGGAATTGGAGGCTGTGAAGCAAGCCAAACTGAAACTAGAGGAAAAGAACAGAGAATTGG
AGGAAGAGCTTAGGAAAGCTCGGGCAGAAGCTGAAGATGCAAGGCAAAAAGCAAAAGATGACGATGATAGTGATATTCCCACAGCCCAGA
GGAAACGGTTTACTAGAGTAGAAATGGCCCGTGTTCTCATGGAGCGAAACCAGTATAAAGAGAGATTGATGGAGCTTCAGGAAGCTGTTC
GATGGACAGAGATGATTCGGGCATCACGAGAAAATCCAGCCATGCAGGAAAAAAAAAGGTCAAGCATTTGGCAGTTTTTCAGCCGACTTT
TCAGCTCCTCAAGTAACACGACTAAGAAGCCTGAACCACCTGTTAATCTGAAGTACAATGCACCCACGTCTCATGTTACTCCGTCCGTCA
AGAAAAGAAGCAGCACCTTATCTCAGCTCCCTGGGGATAAGTCCAAAGCCTTTGATTTCCTTAGTGAAGAAACTGAAGCTAGTTTAGCCT
CACGCAGAGAACAAAAGAGAGAGCAGTATCGTCAGGTAAAAGCACATGTTCAGAAGGAAGACGGTAGAGTGCAGGCTTTTGGCTGGAGTC
TGCCTCAGAAGTACAAACAGGTAACCAATGGTCAAGGTGAAAATAAGATGAAAAATTTACCTGTGCCTGTCTATCTCAGACCTCTGGATG
AAAAAGATACATCAATGAAGCTGTGGTGTGCTGTTGGAGTCAATTTATCTGGTGGGAAGACCAGAGATGGTGGTTCTGTTGTTGGAGCAA
GTGTATTTTACAAGGATGTTGCTGGTTTGGATACAGAAGGCAGTAAACAGCGAAGTGCCTCTCAGAGTAGTTTAGATAAGTTAGATCAGG
AACTTAAGGAACAGCAGAAGGAGTTAAAAAATCAAGAAGAATTATCCAGTCTAGTTTGGATCTGTACCAGCACTCATTCGGCTACAAAAG
TTCTTATTATTGATGCTGTTCAACCTGGCAACATCCTAGACAGTTTCACTGTTTGCAACTCTCATGTTCTGTGCATTGCAAGTGTGCCAG
GTGCACGAGAAACAGACTACCCTGCAGGAGAAGATCTTTCAGAATCTGGTCAGGTAGACAAAGCATCTTTATGTGGAAGTATGACAAGCA
ACAGCTCAGCAGAGACAGACAGCCTGTTAGGAGGCATCACAGTGGTTGGTTGTTCTGCAGAAGGTGTGACGGGAGCTGCCACTTCCCCTA
GTACAAATGGTGCTTCTCCAGTGATGGATAAACCACCAGAAATGGAAGCAGAAAATAGTGAGGTTGATGAAAATGTTCCAACAGCAGAAG
AAGCAACTGAAGCTACAGAAGGGAATGCGGGGTCAGCTGAAGACACAGTGGACATCTCCCAAACTGGCGTCTACACAGAGCATGTCTTTA
CAGATCCTTTGGGAGTTCAGATCCCAGAAGACCTCTCCCCAGTGTATCAGTCGAGCAATGACTCAGATGCATATAAAGATCAAATATCAG
TACTGCCAAATGAACAAGACTTGGTGAGAGAAGAAGCCCAGAAAATGAGTAGTCTTTTACCAACTATGTGGCTTGGAGCTCAAAATGGCT
GTTTGTATGTCCATTCATCTGTAGCCCAGTGGAGGAAATGTCTCCATTCCATTAAACTTAAAGATTCGATTCTCAGTATTGTACACGTGA
AGGGAATCGTGTTAGTAGCCCTGGCTGACGGCACCCTTGCAATCTTTCACAGAGGAGTGGATGGGCAGTGGGATTTGTCAAACTATCACC
TCTTAGACCTTGGACGGCCTCATCATTCCATCCGTTGCATGACTGTGGTACATGACAAAGTCTGGTGTGGCTATAGGAACAAAATCTATG
TGGTGCAGCCAAAGGCCATGAAAATAGAGAAATCTTTTGATGCACATCCCAGGAAGGAGAGCCAAGTGCGACAGCTTGCGTGGGTGGGGG
ATGGCGTGTGGGTCTCCATTCGCTTGGATTCTACGCTCCGTCTCTATCATGCACACACTTATCAACATCTACAGGATGTGGACATTGAGC
CTTATGTAAGCAAAATGTTAGGTACTGGAAAACTGGGCTTCTCTTTTGTGAGAATTACAGCTCTTATGGTGTCTTGTAATCGTTTGTGGG
TGGGGACAGGAAATGGTGTCATTATCTCCATCCCATTGACAGAAACAAATAAAACCTCAGGTGTACCAGGAAATCGTCCTGGAAGTGTAA
TCCGTGTATATGGTGATGAAAACAGTGATAAAGTGACTCCAGGGACATTTATACCCTATTGTTCAATGGCACATGCACAGCTTTGCTTCC
ATGGGCACCGGGATGCTGTGAAATTCTTTGTGGCAGTCCCAGGTCAAGTCATCAGCCCACAAAGTAGCAGTAGTGGCACGGATCTGACGG
GTGACAAAGCAGGGCCATCTGCACAGGAGCCTGGTAGTCAGACGCCCTTGAAGTCTATGCTTGTCATCAGTGGAGGAGAGGGCTACATCG
ACTTCCGAATGGGTGATGAAGGTGGAGAATCAGAACTTCTTGGAGAGGATCTTCCACTTGAACCTTCTGTCACCAAAGCAGAAAGGAGTC
ACTTGATAGTGTGGCAAGTGATGTATGGCAATGAGTGAGCCCATGGGAAACAGGTGGAGATGGGGAAGCCGTCTCTTCTGCATGGTTTAT
TTTCCCTCTATCCTTTTATTTAATGCTCTTTTGTGAGATAAGTTTCACCACATAATGTGTGAGCATTTTTTCCTGTTAACTTTATATTAC
AAAATCCGTTCTACCATAACAATACAGAGGAACTAGCTGTGTTACTGCACCAGTGTTATAGGTAACTTCAGTATATTATGAACAAATCAA
AGAATGTTTACTTCCTGCAAACTGGTGAATTATAGAAAGCAATCCAGATGTGGTTTACTCTGCCACAGTCTAATGTCATTCACTTCATTT
GATGGGGTCACTTGTTAGCTGTCACTAATAATGGAATTAATGGGAAACACTTGATAAATGAAACTGTACCGTTAAATACAATAGCTGAGT
TTTCCCCAGTGTATTGTAAAATTGACACACACTAATACAAGATGGATTATCAGGATGTATCTAAATGTCCCGAGAGGGTTAAAAGCTAAC
TGTAAATTACTTTAACTTTCACTTTCAAATCTGACAAATCTTGTTTATATGGTATATAAAACTTTGTTTTCATCAGATTTGGGGGGGTTT

>10289_10289_2_BRIP1-SPAG9_BRIP1_chr17_59934418_ENST00000259008_SPAG9_chr17_49157065_ENST00000357122_length(amino acids)=1217AA_BP=11
MKEMALHQLVKKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH
QLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKDELSDVSQGGSKATTPASTANSD
VATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKA
FDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEE
KNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQ
FFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQ
AFGWSLPQKYKQVTNGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSL
DKLDQELKEQQKELKNQEELSSLVWICTSTHSATKVLIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKASLC
GSMTSNSSAETDSLLGGITVVGCSAEGVTGAATSPSTNGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAGSAEDTVDISQTGVY
TEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVLPNEQDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSIL
SIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQ
LAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGN
RPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISG

--------------------------------------------------------------
>10289_10289_3_BRIP1-SPAG9_BRIP1_chr17_59934418_ENST00000259008_SPAG9_chr17_49157065_ENST00000505279_length(transcript)=4925nt_BP=647nt
AATTCGTCTCGGGTTGTGTGGTTGAGGGGTCTGGTGGGTCGAGGAAAGGTAACGGCGGCCCCAGTCCTGCACACAAGGCCGGGGAAGTAG
CAGCACCCCCAGGAAGAGGGAGGAGGAAGGGCTCGTGCCCTTTCTTCTCTTCCAGGGCTCCGCTTTATTTGCTCTCAGAAGTCGGTTTCC
TTTCCTTTTCTTCAGTGAATCGGAGCTCAGAGCGTTGCTTCGGTTTCCCTCCAGACAGTTAGGAATCTGAAATAAACAGGAAAGCACTAT
GTCTTCAATGTGGTCTGAATATACAATTGGTGGGGTGAAGATTTACTTTCCTTATAAAGCTTACCCGTCACAGCTTGCTATGATGAATTC
TATTCTCAGAGGATTAAACAGCAAGCAACATTGTTTGTTGGAGAGTCCCACAGGAAGTGGAAAAAGCTTAGCCTTACTTTGTTCTGCTTT
AGCATGGCAACAATCTCTTAGTGGGAAACCAGCAGATGAGGGCGTAAGTGAAAAAGCTGAAGTACAATTGTCATGTTGTTGTGCATGCCA
TTCAAAGGATTTTACAAACAATGACATGAACCAAGGAACTTCACGTCATTTCAACTATCCAAGCACACCACCTTCTGAAAGAAATGGCAC
TTCATCAACTTGTCAAGAAATTCATTGAATTTGAAGACTCTCAAGAACAGGAAAAAAAGGACTTACAGACCCGAGTGGAATCTTTAGAAT
CTCAAACAAGACAACTTGAGCTGAAAGCGAAAAACTATGCTGACCAGATTAGCAGACTTGAAGAAAGAGAAGCAGAACTGAAGAAGGAAT
ATAATGCATTACATCAAAGACACACTGAGATGATCCATAATTATATGGAACATTTAGAAAGAACAAAACTTCATCAGCTCTCAGGGAGTG
ATCAACTAGAATCCACAGCTCATAGTAGAATTAGAAAAGAACGCCCTATATCATTAGGAATTTTCCCATTACCTGCTGGAGATGGATTGC
TTACACCTGATGCTCAGAAAGGAGGAGAGACCCCTGGATCTGAGCAATGGAAATTTCAGGAATTAAGTCAACCACGTTCTCATACCAGCC
TGAAGGATGAGCTTTCTGATGTTAGCCAAGGCGGATCTAAAGCTACCACTCCAGCATCAACAGCTAATTCAGATGTGGCAACAATTCCTA
CTGATACTCCCTTAAAGGAAGAAAACGAAGGATTTGTGAAGGTTACAGATGCGCCAAATAAATCAGAGATAAGCAAACACATTGAAGTAC
AGGTAGCCCAGGAAACTAGAAATGTATCTACTGGCTCTGCTGAAAATGAAGAAAAGTCAGAAGTTCAAGCAATCATCGAATCTACTCCTG
AGCTGGATATGGACAAAGATCTCAGTGGATATAAAGGTTCAAGCACTCCCACCAAAGGCATAGAGAACAAAGCTTTTGATCGCAATACAG
AATCTCTCTTTGAAGAACTGTCTTCAGCTGGCTCAGGCCTAATAGGAGATGTGGATGAAGGAGCAGATTTACTAGGAATGGGTCGGGAAG
TTGAGAATCTTATATTAGAAAATACACAACTGTTGGAAACCAAAAATGCTTTGAACATAGTGAAGAATGATTTGATAGCAAAAGTGGATG
AACTGACCTGTGAGAAAGATGTGCTGCAAGGGGAATTGGAGGCTGTGAAGCAAGCCAAACTGAAACTAGAGGAAAAGAACAGAGAATTGG
AGGAAGAGCTTAGGAAAGCTCGGGCAGAAGCTGAAGATGCAAGGCAAAAAGCAAAAGATGACGATGATAGTGATATTCCCACAGCCCAGA
GGAAACGGTTTACTAGAGTAGAAATGGCCCGTGTTCTCATGGAGCGAAACCAGTATAAAGAGAGATTGATGGAGCTTCAGGAAGCTGTTC
GATGGACAGAGATGATTCGGGCATCACGAGAAAATCCAGCCATGCAGGAAAAAAAAAGGTCAAGCATTTGGCAGTTTGTGCCAACTCGTT
TCAGCCGACTTTTCAGCTCCTCAAGTAACACGACTAAGAAGCCTGAACCACCTGTTAATCTGAAGTACAATGCACCCACGTCTCATGTTA
CTCCGTCCGTCAAGAAAAGAAGCAGCACCTTATCTCAGCTCCCTGGGGATAAGTCCAAAGCCTTTGATTTCCTTAGTGAAGAAACTGAAG
CTAGTTTAGCCTCACGCAGAGAACAAAAGAGAGAGCAGTATCGTCAGGTAAAAGCACATGTTCAGAAGGAAGACGGTAGAGTGCAGGCTT
TTGGCTGGAGTCTGCCTCAGAAGTACAAACAGGTAACCAATGGTCAAGGTGAAAATAAGATGAAAAATTTACCTGTGCCTGTCTATCTCA
GACCTCTGGATGAAAAAGATACATCAATGAAGCTGTGGTGTGCTGTTGGAGTCAATTTATCTGGTGGGAAGACCAGAGATGGTGGTTCTG
TTGTTGGAGCAAGTGTATTTTACAAGGATGTTGCTGGTTTGGATACAGAAGGCAGTAAACAGCGAAGTGCCTCTCAGAGTAGTTTAGATA
AGTTAGATCAGGAACTTAAGGAACAGCAGAAGGAGTTAAAAAATCAAGAAGAATTATCCAGTCTAGTTTGGATCTGTACCAGCACTCATT
CGGCTACAAAAGTTCTTATTATTGATGCTGTTCAACCTGGCAACATCCTAGACAGTTTCACTGTTTGCAACTCTCATGTTCTGTGCATTG
CAAGTGTGCCAGGTGCACGAGAAACAGACTACCCTGCAGGAGAAGATCTTTCAGAATCTGGTCAGGTAGACAAAGCATCTTTATGTGGAA
GTATGACAAGCAACAGCTCAGCAGAGACAGACAGCCTGTTAGGAGGCATCACAGTGGTTGGTTGTTCTGCAGAAGGTGTGACGGGAGCTG
CCACTTCCCCTAGTACAAATGGTGCTTCTCCAGTGATGGATAAACCACCAGAAATGGAAGCAGAAAATAGTGAGGTTGATGAAAATGTTC
CAACAGCAGAAGAAGCAACTGAAGCTACAGAAGGGAATGCGGGGTCAGCTGAAGACACAGTGGACATCTCCCAAACTGGCGTCTACACAG
AGCATGTCTTTACAGATCCTTTGGGAGTTCAGATCCCAGAAGACCTCTCCCCAGTGTATCAGTCGAGCAATGACTCAGATGCATATAAAG
ATCAAATATCAGTACTGCCAAATGAACAAGACTTGGTGAGAGAAGAAGCCCAGAAAATGAGTAGTCTTTTACCAACTATGTGGCTTGGAG
CTCAAAATGGCTGTTTGTATGTCCATTCATCTGTAGCCCAGTGGAGGAAATGTCTCCATTCCATTAAACTTAAAGATTCGATTCTCAGTA
TTGTACACGTGAAGGGAATCGTGTTAGTAGCCCTGGCTGACGGCACCCTTGCAATCTTTCACAGAGGAGTGGATGGGCAGTGGGATTTGT
CAAACTATCACCTCTTAGACCTTGGACGGCCTCATCATTCCATCCGTTGCATGACTGTGGTACATGACAAAGTCTGGTGTGGCTATAGGA
ACAAAATCTATGTGGTGCAGCCAAAGGCCATGAAAATAGAGAAATCTTTTGATGCACATCCCAGGAAGGAGAGCCAAGTGCGACAGCTTG
CGTGGGTGGGGGATGGCGTGTGGGTCTCCATTCGCTTGGATTCTACGCTCCGTCTCTATCATGCACACACTTATCAACATCTACAGGATG
TGGACATTGAGCCTTATGTAAGCAAAATGTTAGGTACTGGAAAACTGGGCTTCTCTTTTGTGAGAATTACAGCTCTTATGGTGTCTTGTA
ATCGTTTGTGGGTGGGGACAGGAAATGGTGTCATTATCTCCATCCCATTGACAGAAACAAATAAAACCTCAGGTGTACCAGGAAATCGTC
CTGGAAGTGTAATCCGTGTATATGGTGATGAAAACAGTGATAAAGTGACTCCAGGGACATTTATACCCTATTGTTCAATGGCACATGCAC
AGCTTTGCTTCCATGGGCACCGGGATGCTGTGAAATTCTTTGTGGCAGTCCCAGGTCAAGTCATCAGCCCACAAAGTAGCAGTAGTGGCA
CGGATCTGACGGGTGACAAAGCAGGGCCATCTGCACAGGAGCCTGGTAGTCAGACGCCCTTGAAGTCTATGCTTGTCATCAGTGGAGGAG
AGGGCTACATCGACTTCCGAATGGGTGATGAAGGTGGAGAATCAGAACTTCTTGGAGAGGATCTTCCACTTGAACCTTCTGTCACCAAAG
CAGAAAGGAGTCACTTGATAGTGTGGCAAGTGATGTATGGCAATGAGTGAGCCCATGGGAAACAGGTGGAGATGGGGAAGCCGTCTCTTC
TGCATGGTTTATTTTCCCTCTATCCTTTTATTTAATGCTCTTTTGTGAGATAAGTTTCACCACATAATGTGTGAGCATTTTTTCCTGTTA
ACTTTATATTACAAAATCCGTTCTACCATAACAATACAGAGGAACTAGCTGTGTTACTGCACCAGTGTTATAGGTAACTTCAGTATATTA
TGAACAAATCAAAGAATGTTTACTTCCTGCAAACTGGTGAATTATAGAAAGCAATCCAGATGTGGTTTACTCTGCCACAGTCTAATGTCA
TTCACTTCATTTGATGGGGTCACTTGTTAGCTGTCACTAATAATGGAATTAATGGGAAACACTTGATAAATGAAACTGTACCGTTAAATA
CAATAGCTGAGTTTTCCCCAGTGTATTGTAAAATTGACACACACTAATACAAGATGGATTATCAGGATGTATCTAAATGTCCCGAGAGGG
TTAAAAGCTAACTGTAAATTACTTTAACTTTCACTTTCAAATCTGACAAATCTTGTTTATATGGTATATAAAACTTTGTTTTCATCAGAT

>10289_10289_3_BRIP1-SPAG9_BRIP1_chr17_59934418_ENST00000259008_SPAG9_chr17_49157065_ENST00000505279_length(amino acids)=1221AA_BP=11
MKEMALHQLVKKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH
QLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKDELSDVSQGGSKATTPASTANSD
VATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKA
FDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEE
KNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQ
FVPTRFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKED
GRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSAS
QSSLDKLDQELKEQQKELKNQEELSSLVWICTSTHSATKVLIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDK
ASLCGSMTSNSSAETDSLLGGITVVGCSAEGVTGAATSPSTNGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAGSAEDTVDISQ
TGVYTEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVLPNEQDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLK
DSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKES
QVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSG
VPGNRPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQTPLKSML

--------------------------------------------------------------
>10289_10289_4_BRIP1-SPAG9_BRIP1_chr17_59934419_ENST00000259008_SPAG9_chr17_49157065_ENST00000262013_length(transcript)=8408nt_BP=647nt
AATTCGTCTCGGGTTGTGTGGTTGAGGGGTCTGGTGGGTCGAGGAAAGGTAACGGCGGCCCCAGTCCTGCACACAAGGCCGGGGAAGTAG
CAGCACCCCCAGGAAGAGGGAGGAGGAAGGGCTCGTGCCCTTTCTTCTCTTCCAGGGCTCCGCTTTATTTGCTCTCAGAAGTCGGTTTCC
TTTCCTTTTCTTCAGTGAATCGGAGCTCAGAGCGTTGCTTCGGTTTCCCTCCAGACAGTTAGGAATCTGAAATAAACAGGAAAGCACTAT
GTCTTCAATGTGGTCTGAATATACAATTGGTGGGGTGAAGATTTACTTTCCTTATAAAGCTTACCCGTCACAGCTTGCTATGATGAATTC
TATTCTCAGAGGATTAAACAGCAAGCAACATTGTTTGTTGGAGAGTCCCACAGGAAGTGGAAAAAGCTTAGCCTTACTTTGTTCTGCTTT
AGCATGGCAACAATCTCTTAGTGGGAAACCAGCAGATGAGGGCGTAAGTGAAAAAGCTGAAGTACAATTGTCATGTTGTTGTGCATGCCA
TTCAAAGGATTTTACAAACAATGACATGAACCAAGGAACTTCACGTCATTTCAACTATCCAAGCACACCACCTTCTGAAAGAAATGGCAC
TTCATCAACTTGTCAAGAAATTCATTGAATTTGAAGACTCTCAAGAACAGGAAAAAAAGGACTTACAGACCCGAGTGGAATCTTTAGAAT
CTCAAACAAGACAACTTGAGCTGAAAGCGAAAAACTATGCTGACCAGATTAGCAGACTTGAAGAAAGAGAAGCAGAACTGAAGAAGGAAT
ATAATGCATTACATCAAAGACACACTGAGATGATCCATAATTATATGGAACATTTAGAAAGAACAAAACTTCATCAGCTCTCAGGGAGTG
ATCAACTAGAATCCACAGCTCATAGTAGAATTAGAAAAGAACGCCCTATATCATTAGGAATTTTCCCATTACCTGCTGGAGATGGATTGC
TTACACCTGATGCTCAGAAAGGAGGAGAGACCCCTGGATCTGAGCAATGGAAATTTCAGGAATTAAGTCAACCACGTTCTCATACCAGCC
TGAAGGTCAGCAATAGTCCTGAACCTCAGAAGGCTGTAGAACAGGAGGATGAGCTTTCTGATGTTAGCCAAGGCGGATCTAAAGCTACCA
CTCCAGCATCAACAGCTAATTCAGATGTGGCAACAATTCCTACTGATACTCCCTTAAAGGAAGAAAACGAAGGATTTGTGAAGGTTACAG
ATGCGCCAAATAAATCAGAGATAAGCAAACACATTGAAGTACAGGTAGCCCAGGAAACTAGAAATGTATCTACTGGCTCTGCTGAAAATG
AAGAAAAGTCAGAAGTTCAAGCAATCATCGAATCTACTCCTGAGCTGGATATGGACAAAGATCTCAGTGGATATAAAGGTTCAAGCACTC
CCACCAAAGGCATAGAGAACAAAGCTTTTGATCGCAATACAGAATCTCTCTTTGAAGAACTGTCTTCAGCTGGCTCAGGCCTAATAGGAG
ATGTGGATGAAGGAGCAGATTTACTAGGAATGGGTCGGGAAGTTGAGAATCTTATATTAGAAAATACACAACTGTTGGAAACCAAAAATG
CTTTGAACATAGTGAAGAATGATTTGATAGCAAAAGTGGATGAACTGACCTGTGAGAAAGATGTGCTGCAAGGGGAATTGGAGGCTGTGA
AGCAAGCCAAACTGAAACTAGAGGAAAAGAACAGAGAATTGGAGGAAGAGCTTAGGAAAGCTCGGGCAGAAGCTGAAGATGCAAGGCAAA
AAGCAAAAGATGACGATGATAGTGATATTCCCACAGCCCAGAGGAAACGGTTTACTAGAGTAGAAATGGCCCGTGTTCTCATGGAGCGAA
ACCAGTATAAAGAGAGATTGATGGAGCTTCAGGAAGCTGTTCGATGGACAGAGATGATTCGGGCATCACGAGAAAATCCAGCCATGCAGG
AAAAAAAAAGGTCAAGCATTTGGCAGTTTTTCAGCCGACTTTTCAGCTCCTCAAGTAACACGACTAAGAAGCCTGAACCACCTGTTAATC
TGAAGTACAATGCACCCACGTCTCATGTTACTCCGTCCGTCAAGAAAAGAAGCAGCACCTTATCTCAGCTCCCTGGGGATAAGTCCAAAG
CCTTTGATTTCCTTAGTGAAGAAACTGAAGCTAGTTTAGCCTCACGCAGAGAACAAAAGAGAGAGCAGTATCGTCAGGTAAAAGCACATG
TTCAGAAGGAAGACGGTAGAGTGCAGGCTTTTGGCTGGAGTCTGCCTCAGAAGTACAAACAGGTAACCAATGGTCAAGGTGAAAATAAGA
TGAAAAATTTACCTGTGCCTGTCTATCTCAGACCTCTGGATGAAAAAGATACATCAATGAAGCTGTGGTGTGCTGTTGGAGTCAATTTAT
CTGGTGGGAAGACCAGAGATGGTGGTTCTGTTGTTGGAGCAAGTGTATTTTACAAGGATGTTGCTGGTTTGGATACAGAAGGCAGTAAAC
AGCGAAGTGCCTCTCAGAGTAGTTTAGATAAGTTAGATCAGGAACTTAAGGAACAGCAGAAGGAGTTAAAAAATCAAGAAGAATTATCCA
GTCTAGTTTGGATCTGTACCAGCACTCATTCGGCTACAAAAGTTCTTATTATTGATGCTGTTCAACCTGGCAACATCCTAGACAGTTTCA
CTGTTTGCAACTCTCATGTTCTGTGCATTGCAAGTGTGCCAGGTGCACGAGAAACAGACTACCCTGCAGGAGAAGATCTTTCAGAATCTG
GTCAGGTAGACAAAGCATCTTTATGTGGAAGTATGACAAGCAACAGCTCAGCAGAGACAGACAGCCTGTTAGGAGGCATCACAGTGGTTG
GTTGTTCTGCAGAAGGTGTGACGGGAGCTGCCACTTCCCCTAGTACAAATGGTGCTTCTCCAGTGATGGATAAACCACCAGAAATGGAAG
CAGAAAATAGTGAGGTTGATGAAAATGTTCCAACAGCAGAAGAAGCAACTGAAGCTACAGAAGGGAATGCGGGGTCAGCTGAAGACACAG
TGGACATCTCCCAAACTGGCGTCTACACAGAGCATGTCTTTACAGATCCTTTGGGAGTTCAGATCCCAGAAGACCTCTCCCCAGTGTATC
AGTCGAGCAATGACTCAGATGCATATAAAGATCAAATATCAGTACTGCCAAATGAACAAGACTTGGTGAGAGAAGAAGCCCAGAAAATGA
GTAGTCTTTTACCAACTATGTGGCTTGGAGCTCAAAATGGCTGTTTGTATGTCCATTCATCTGTAGCCCAGTGGAGGAAATGTCTCCATT
CCATTAAACTTAAAGATTCGATTCTCAGTATTGTACACGTGAAGGGAATCGTGTTAGTAGCCCTGGCTGACGGCACCCTTGCAATCTTTC
ACAGAGGAGTGGATGGGCAGTGGGATTTGTCAAACTATCACCTCTTAGACCTTGGACGGCCTCATCATTCCATCCGTTGCATGACTGTGG
TACATGACAAAGTCTGGTGTGGCTATAGGAACAAAATCTATGTGGTGCAGCCAAAGGCCATGAAAATAGAGAAATCTTTTGATGCACATC
CCAGGAAGGAGAGCCAAGTGCGACAGCTTGCGTGGGTGGGGGATGGCGTGTGGGTCTCCATTCGCTTGGATTCTACGCTCCGTCTCTATC
ATGCACACACTTATCAACATCTACAGGATGTGGACATTGAGCCTTATGTAAGCAAAATGTTAGGTACTGGAAAACTGGGCTTCTCTTTTG
TGAGAATTACAGCTCTTATGGTGTCTTGTAATCGTTTGTGGGTGGGGACAGGAAATGGTGTCATTATCTCCATCCCATTGACAGAAACAA
ATAAAACCTCAGGTGTACCAGGAAATCGTCCTGGAAGTGTAATCCGTGTATATGGTGATGAAAACAGTGATAAAGTGACTCCAGGGACAT
TTATACCCTATTGTTCAATGGCACATGCACAGCTTTGCTTCCATGGGCACCGGGATGCTGTGAAATTCTTTGTGGCAGTCCCAGGTCAAG
TCATCAGCCCACAAAGTAGCAGTAGTGGCACGGATCTGACGGGTGACAAAGCAGGGCCATCTGCACAGGAGCCTGGTAGTCAGACGCCCT
TGAAGTCTATGCTTGTCATCAGTGGAGGAGAGGGCTACATCGACTTCCGAATGGGTGATGAAGGTGGAGAATCAGAACTTCTTGGAGAGG
ATCTTCCACTTGAACCTTCTGTCACCAAAGCAGAAAGGAGTCACTTGATAGTGTGGCAAGTGATGTATGGCAATGAGTGAGCCCATGGGA
AACAGGTGGAGATGGGGAAGCCGTCTCTTCTGCATGGTTTATTTTCCCTCTATCCTTTTATTTAATGCTCTTTTGTGAGATAAGTTTCAC
CACATAATGTGTGAGCATTTTTTCCTGTTAACTTTATATTACAAAATCCGTTCTACCATAACAATACAGAGGAACTAGCTGTGTTACTGC
ACCAGTGTTATAGGTAACTTCAGTATATTATGAACAAATCAAAGAATGTTTACTTCCTGCAAACTGGTGAATTATAGAAAGCAATCCAGA
TGTGGTTTACTCTGCCACAGTCTAATGTCATTCACTTCATTTGATGGGGTCACTTGTTAGCTGTCACTAATAATGGAATTAATGGGAAAC
ACTTGATAAATGAAACTGTACCGTTAAATACAATAGCTGAGTTTTCCCCAGTGTATTGTAAAATTGACACACACTAATACAAGATGGATT
ATCAGGATGTATCTAAATGTCCCGAGAGGGTTAAAAGCTAACTGTAAATTACTTTAACTTTCACTTTCAAATCTGACAAATCTTGTTTAT
ATGGTATATAAAACTTTGTTTTCATCAGATTTGGGGGGGTTTTATATTAAAGAAATTAAGACTACACTATTTAAATAAACGTTTCCTGTT
TCTGACTTATTAGAGCTCTAAAGTTTATGAGGCCTACTTCTCTGAATATTCTGATGGGTTTTTTTTGAGACCAGTCTCATTTTCATACTG
ACATGTCTGAAAGATTTATTATTTATAAAGCTTAGGACATACTCTGGGAAGCTTAGAAGATACTTCAGCACTGGGAGGATTTTTTAAAGG
AAATGTGTTTTGTATTTCTTGTACCAGAGAATGGTGATGTTGATTGAGTTTTTTCCATGTAAAAAATGTACTTGTTTGCCAAATGTTCCT
AGATTGCTCTTAACCTGTTAATACAAGTAAAACTGTAGTGGGGATGGAGTCTGGCCTAAGTACAGAATGAGGGATTTAATTAGAAAAGTT
ATTTTCTTTTGTTCTGTATCAAACTGCAGAACAGCTATATACTTGGTATTTTGTACGTGAATAACGTTTTAGCTTTTGTGCCCTTTTGAG
CTTGAAGGGTTATCCTCAAAGGGGAAAACTATGAAGGGGAAGAAGACAAACCTAAGATACCATAAAGTAAAGGTTGACATTACATATTTT
CATTCACAATGCCCATTAAAAAAAAAAAATAGGTTGGGCATGGTGGCTCACGCCTGTAATCCCAACACTTTAGGAGGCTGAGGCAGATGG
ATTGCTTGAGCCCAGGAGTTCAAGACCAGCCTGGGCAACATGGCGAAACCCTGTCTCTACCAAAAAAAAAAAACAAAATAAATTAACCGG
GTGTGGTGGCACATGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGTGGGAGGATGACCTGGGCCCAGGAGGTGGAGGTTGCAGTGAGCC
TTGATAGCACCACTGCACTCCAGCCTGGGTGACGGAGCAAGACCCTGTCTCAAAACAGACAAACAAGCAAAAAATAGATTAAAGTCTGGA
TTTCACTGATTTTCTTGCTTAATAAGTTTTTTAAAACCACGATGCTGCAATTTTTTCCCTCTCAAGCTTCTTGAAAATGTGTGATTTACC
CTTTTTTATCTATTACTCTAGGCAAAGCTAAATATGATTTTTTTTTTTTTTTTTGAGACGGAGTCTGGCTCTGTTGCCCAGGCTGGAATG
CAGTGGTGCGATCTCAGCTCACTGCAACCTCCACCTCTCAGGTTCAAGTAGTTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGG
TGTGTGCCACCCTGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCACATTGGCCAGGCTGGTCTCAAACTCCTGACCTC
AGATGATCTACCCGCCTTGGCCTCCCGAAGTGCTTGAATTACAGGCGTGAGCCCCCGCGCCGGTCCGAAGCAAAGCTAAATGTAATTTTA
TGTACTGTTTTAACAGTATAAACCTATGGGATAAAGGCCCCCAATCATCAGAAGGACTACTGAAAAGAAAAGAAAGCAAACGTAGATGTC
AAATTGTCTAAACATTCTTAAGTACCACTGATTTTTTTTTTCTGGACTATTATACAAAGATGTCTGTAAAAAGTATACCAGTGGCTTTTA
TGCATATACACGATTAGGCTAGATTGTGAAGTACATGGGATTTCATGAGCCAGAGGAGGCATTTGGATCCATTGGGCCACATGTGACTAT
AAGCACATTGTGTACACAATAAAATTGTAGCCACTCATGTATTAAAACTGTTTTGGTAAAAGCTGTATTAAAAGAATAATTTTTTGCTTG
AGCTACTTAGTCACTTTTTTGCAGGGCACCAAAATGTAGGCTACTTTTCCATAGCTTGTTTGCTATGTTTTTATTTCATCTTAAATCTGA
GCCATTTTTGGCAATATCTTTTAAAAAATCATTATTAAACATTTATTGGAAATGTTGTATAGATTCACAAGAAAGAGACACCAAAGTGTT
TGGGAATTTTAATCCCAAGAAGTAAACATCCCAGAGTCAGATCCCATTTGCTGTTGTTCAGCCATGTTTGTATGACTGAATGTAATTTAG
GAAATCAGGAGTTAGAGATGAAAAATACAAACATGTCAAATGGTTGTAATTGCTTTTTTTGAACTTACTGGCTTTAACTTAAGTAATATA
GGTGTGTAGTTGTTTTATCTAAAGATGTCAGATTATCTGTGGCCCTGTTAATTAACTGCAGGGACCAGAGAGAGGACAAAAATGCCTGTA
TAATTTGCTTTAAAGGCTTGTCCTTATGTTTGTAATTTCAGTTAAATATTTTCTACAGATTGCTTCACTTCCCCTTTCCCCCAATAACAA
GTTCATATTCTTGTAATGTTTACTTTGGTCAACGTGGTAATTTTTGGAAGAAAATGCCAAAATGTAAGCTTCTCACAAGCAGCAAAGGAA
TGTAACTGCCTGTAGCTACCACATCAAGGGAGAGAAGAGGCTTGCGTACTTTGGGTTGATCTCACTGTACAAAAAAAGTGTACCCCTATT
GGAAGAAATAAGGAATACTTGAAGGTTTCTCCTTTTTTTACACTTGAGTCATGTGCAAGGTTGAACCATATGAAATTGCCAGTGTTCAAC
CATTGCTGATCTGCAAAAGCGACAATATCATATGCCTCAACCTAACACTTACTCTTAAATGCAGGTTAAAATCTCTGTGAGGCAAAGGGA
TAATATTCTCTAGGAACTCACTTTTGAGAGTATTTTTCTCTAACCCATGTGGATCTAAATTTTAAAAATAGGAATGAATCTCTTAATTGC
AGCTTGTGGAGAGTATAAAACATTTTGAGCACAATATGCAGCACATAACTTTTCAGATTGTGTTTGCATAGAAAAGGTTAAAATCAATTC
TTTCAGTTACTGTATTGTTCATTTCTTGTAAAGGTCTTCCTACATTTGAGACGAGACCCTTTAACATAGGCTGCCTTAGTAACAAAATAA
AACAGATGTGTCATAATATTAACTGTCCTAAAGAACATGTGTCTTGCAAATGCCATGGAACTGAATATTTATTTCCTTGTGAGTATTATG
ACCGTTACCAAAGGACTCAACCAGATTTAGGGCTCTTCTTAATTGATCATGTTCAGAAAGGGACTCATTTGGTCCCACTTTGTAACATGG
GAAGAGTAGAAGAGAAAATTAAATGTGGAAATCATAAATGCTTTTCTAACAGGGTTATGCTATTCTGTAACACTAAATGTCTGTCTTTTC
TCTTAAAAGATTAAGTTTTATTAATTTTGTCATACATTTCTCTATTTGAATATATCTTAACCATTTTATGTTCCAAATTCGTTTTTTGTC
CAAGACATTCTATCAGAATTTTACTTGCCTCTATAATCTGAAAAATGGGTTCTAGAATGTCCCACTTGCTGTCTCTTAGAGGCTGAGCTT
CATTTCTATGAGCAAAGAGCTCATTTAGCAATGTAGTTATTTCAGTATTTATTTCTATTATGGAATCCCTGGGGTTCAGAATGTAACTTT

>10289_10289_4_BRIP1-SPAG9_BRIP1_chr17_59934419_ENST00000259008_SPAG9_chr17_49157065_ENST00000262013_length(amino acids)=1231AA_BP=11
MKEMALHQLVKKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH
QLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQEDELSDVSQG
GSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGY
KGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQG
ELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRE
NPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYR
QVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLD
TEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLVWICTSTHSATKVLIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGE
DLSESGQVDKASLCGSMTSNSSAETDSLLGGITVVGCSAEGVTGAATSPSTNGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAG
SAEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVLPNEQDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQW
RKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEK
SFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISI
PLTETNKTSGVPGNRPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEP

--------------------------------------------------------------
>10289_10289_5_BRIP1-SPAG9_BRIP1_chr17_59934419_ENST00000259008_SPAG9_chr17_49157065_ENST00000357122_length(transcript)=4896nt_BP=647nt
AATTCGTCTCGGGTTGTGTGGTTGAGGGGTCTGGTGGGTCGAGGAAAGGTAACGGCGGCCCCAGTCCTGCACACAAGGCCGGGGAAGTAG
CAGCACCCCCAGGAAGAGGGAGGAGGAAGGGCTCGTGCCCTTTCTTCTCTTCCAGGGCTCCGCTTTATTTGCTCTCAGAAGTCGGTTTCC
TTTCCTTTTCTTCAGTGAATCGGAGCTCAGAGCGTTGCTTCGGTTTCCCTCCAGACAGTTAGGAATCTGAAATAAACAGGAAAGCACTAT
GTCTTCAATGTGGTCTGAATATACAATTGGTGGGGTGAAGATTTACTTTCCTTATAAAGCTTACCCGTCACAGCTTGCTATGATGAATTC
TATTCTCAGAGGATTAAACAGCAAGCAACATTGTTTGTTGGAGAGTCCCACAGGAAGTGGAAAAAGCTTAGCCTTACTTTGTTCTGCTTT
AGCATGGCAACAATCTCTTAGTGGGAAACCAGCAGATGAGGGCGTAAGTGAAAAAGCTGAAGTACAATTGTCATGTTGTTGTGCATGCCA
TTCAAAGGATTTTACAAACAATGACATGAACCAAGGAACTTCACGTCATTTCAACTATCCAAGCACACCACCTTCTGAAAGAAATGGCAC
TTCATCAACTTGTCAAGAAATTCATTGAATTTGAAGACTCTCAAGAACAGGAAAAAAAGGACTTACAGACCCGAGTGGAATCTTTAGAAT
CTCAAACAAGACAACTTGAGCTGAAAGCGAAAAACTATGCTGACCAGATTAGCAGACTTGAAGAAAGAGAAGCAGAACTGAAGAAGGAAT
ATAATGCATTACATCAAAGACACACTGAGATGATCCATAATTATATGGAACATTTAGAAAGAACAAAACTTCATCAGCTCTCAGGGAGTG
ATCAACTAGAATCCACAGCTCATAGTAGAATTAGAAAAGAACGCCCTATATCATTAGGAATTTTCCCATTACCTGCTGGAGATGGATTGC
TTACACCTGATGCTCAGAAAGGAGGAGAGACCCCTGGATCTGAGCAATGGAAATTTCAGGAATTAAGTCAACCACGTTCTCATACCAGCC
TGAAGGATGAGCTTTCTGATGTTAGCCAAGGCGGATCTAAAGCTACCACTCCAGCATCAACAGCTAATTCAGATGTGGCAACAATTCCTA
CTGATACTCCCTTAAAGGAAGAAAACGAAGGATTTGTGAAGGTTACAGATGCGCCAAATAAATCAGAGATAAGCAAACACATTGAAGTAC
AGGTAGCCCAGGAAACTAGAAATGTATCTACTGGCTCTGCTGAAAATGAAGAAAAGTCAGAAGTTCAAGCAATCATCGAATCTACTCCTG
AGCTGGATATGGACAAAGATCTCAGTGGATATAAAGGTTCAAGCACTCCCACCAAAGGCATAGAGAACAAAGCTTTTGATCGCAATACAG
AATCTCTCTTTGAAGAACTGTCTTCAGCTGGCTCAGGCCTAATAGGAGATGTGGATGAAGGAGCAGATTTACTAGGAATGGGTCGGGAAG
TTGAGAATCTTATATTAGAAAATACACAACTGTTGGAAACCAAAAATGCTTTGAACATAGTGAAGAATGATTTGATAGCAAAAGTGGATG
AACTGACCTGTGAGAAAGATGTGCTGCAAGGGGAATTGGAGGCTGTGAAGCAAGCCAAACTGAAACTAGAGGAAAAGAACAGAGAATTGG
AGGAAGAGCTTAGGAAAGCTCGGGCAGAAGCTGAAGATGCAAGGCAAAAAGCAAAAGATGACGATGATAGTGATATTCCCACAGCCCAGA
GGAAACGGTTTACTAGAGTAGAAATGGCCCGTGTTCTCATGGAGCGAAACCAGTATAAAGAGAGATTGATGGAGCTTCAGGAAGCTGTTC
GATGGACAGAGATGATTCGGGCATCACGAGAAAATCCAGCCATGCAGGAAAAAAAAAGGTCAAGCATTTGGCAGTTTTTCAGCCGACTTT
TCAGCTCCTCAAGTAACACGACTAAGAAGCCTGAACCACCTGTTAATCTGAAGTACAATGCACCCACGTCTCATGTTACTCCGTCCGTCA
AGAAAAGAAGCAGCACCTTATCTCAGCTCCCTGGGGATAAGTCCAAAGCCTTTGATTTCCTTAGTGAAGAAACTGAAGCTAGTTTAGCCT
CACGCAGAGAACAAAAGAGAGAGCAGTATCGTCAGGTAAAAGCACATGTTCAGAAGGAAGACGGTAGAGTGCAGGCTTTTGGCTGGAGTC
TGCCTCAGAAGTACAAACAGGTAACCAATGGTCAAGGTGAAAATAAGATGAAAAATTTACCTGTGCCTGTCTATCTCAGACCTCTGGATG
AAAAAGATACATCAATGAAGCTGTGGTGTGCTGTTGGAGTCAATTTATCTGGTGGGAAGACCAGAGATGGTGGTTCTGTTGTTGGAGCAA
GTGTATTTTACAAGGATGTTGCTGGTTTGGATACAGAAGGCAGTAAACAGCGAAGTGCCTCTCAGAGTAGTTTAGATAAGTTAGATCAGG
AACTTAAGGAACAGCAGAAGGAGTTAAAAAATCAAGAAGAATTATCCAGTCTAGTTTGGATCTGTACCAGCACTCATTCGGCTACAAAAG
TTCTTATTATTGATGCTGTTCAACCTGGCAACATCCTAGACAGTTTCACTGTTTGCAACTCTCATGTTCTGTGCATTGCAAGTGTGCCAG
GTGCACGAGAAACAGACTACCCTGCAGGAGAAGATCTTTCAGAATCTGGTCAGGTAGACAAAGCATCTTTATGTGGAAGTATGACAAGCA
ACAGCTCAGCAGAGACAGACAGCCTGTTAGGAGGCATCACAGTGGTTGGTTGTTCTGCAGAAGGTGTGACGGGAGCTGCCACTTCCCCTA
GTACAAATGGTGCTTCTCCAGTGATGGATAAACCACCAGAAATGGAAGCAGAAAATAGTGAGGTTGATGAAAATGTTCCAACAGCAGAAG
AAGCAACTGAAGCTACAGAAGGGAATGCGGGGTCAGCTGAAGACACAGTGGACATCTCCCAAACTGGCGTCTACACAGAGCATGTCTTTA
CAGATCCTTTGGGAGTTCAGATCCCAGAAGACCTCTCCCCAGTGTATCAGTCGAGCAATGACTCAGATGCATATAAAGATCAAATATCAG
TACTGCCAAATGAACAAGACTTGGTGAGAGAAGAAGCCCAGAAAATGAGTAGTCTTTTACCAACTATGTGGCTTGGAGCTCAAAATGGCT
GTTTGTATGTCCATTCATCTGTAGCCCAGTGGAGGAAATGTCTCCATTCCATTAAACTTAAAGATTCGATTCTCAGTATTGTACACGTGA
AGGGAATCGTGTTAGTAGCCCTGGCTGACGGCACCCTTGCAATCTTTCACAGAGGAGTGGATGGGCAGTGGGATTTGTCAAACTATCACC
TCTTAGACCTTGGACGGCCTCATCATTCCATCCGTTGCATGACTGTGGTACATGACAAAGTCTGGTGTGGCTATAGGAACAAAATCTATG
TGGTGCAGCCAAAGGCCATGAAAATAGAGAAATCTTTTGATGCACATCCCAGGAAGGAGAGCCAAGTGCGACAGCTTGCGTGGGTGGGGG
ATGGCGTGTGGGTCTCCATTCGCTTGGATTCTACGCTCCGTCTCTATCATGCACACACTTATCAACATCTACAGGATGTGGACATTGAGC
CTTATGTAAGCAAAATGTTAGGTACTGGAAAACTGGGCTTCTCTTTTGTGAGAATTACAGCTCTTATGGTGTCTTGTAATCGTTTGTGGG
TGGGGACAGGAAATGGTGTCATTATCTCCATCCCATTGACAGAAACAAATAAAACCTCAGGTGTACCAGGAAATCGTCCTGGAAGTGTAA
TCCGTGTATATGGTGATGAAAACAGTGATAAAGTGACTCCAGGGACATTTATACCCTATTGTTCAATGGCACATGCACAGCTTTGCTTCC
ATGGGCACCGGGATGCTGTGAAATTCTTTGTGGCAGTCCCAGGTCAAGTCATCAGCCCACAAAGTAGCAGTAGTGGCACGGATCTGACGG
GTGACAAAGCAGGGCCATCTGCACAGGAGCCTGGTAGTCAGACGCCCTTGAAGTCTATGCTTGTCATCAGTGGAGGAGAGGGCTACATCG
ACTTCCGAATGGGTGATGAAGGTGGAGAATCAGAACTTCTTGGAGAGGATCTTCCACTTGAACCTTCTGTCACCAAAGCAGAAAGGAGTC
ACTTGATAGTGTGGCAAGTGATGTATGGCAATGAGTGAGCCCATGGGAAACAGGTGGAGATGGGGAAGCCGTCTCTTCTGCATGGTTTAT
TTTCCCTCTATCCTTTTATTTAATGCTCTTTTGTGAGATAAGTTTCACCACATAATGTGTGAGCATTTTTTCCTGTTAACTTTATATTAC
AAAATCCGTTCTACCATAACAATACAGAGGAACTAGCTGTGTTACTGCACCAGTGTTATAGGTAACTTCAGTATATTATGAACAAATCAA
AGAATGTTTACTTCCTGCAAACTGGTGAATTATAGAAAGCAATCCAGATGTGGTTTACTCTGCCACAGTCTAATGTCATTCACTTCATTT
GATGGGGTCACTTGTTAGCTGTCACTAATAATGGAATTAATGGGAAACACTTGATAAATGAAACTGTACCGTTAAATACAATAGCTGAGT
TTTCCCCAGTGTATTGTAAAATTGACACACACTAATACAAGATGGATTATCAGGATGTATCTAAATGTCCCGAGAGGGTTAAAAGCTAAC
TGTAAATTACTTTAACTTTCACTTTCAAATCTGACAAATCTTGTTTATATGGTATATAAAACTTTGTTTTCATCAGATTTGGGGGGGTTT

>10289_10289_5_BRIP1-SPAG9_BRIP1_chr17_59934419_ENST00000259008_SPAG9_chr17_49157065_ENST00000357122_length(amino acids)=1217AA_BP=11
MKEMALHQLVKKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH
QLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKDELSDVSQGGSKATTPASTANSD
VATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKA
FDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEE
KNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQ
FFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQ
AFGWSLPQKYKQVTNGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSL
DKLDQELKEQQKELKNQEELSSLVWICTSTHSATKVLIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKASLC
GSMTSNSSAETDSLLGGITVVGCSAEGVTGAATSPSTNGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAGSAEDTVDISQTGVY
TEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVLPNEQDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSIL
SIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQ
LAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGN
RPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISG

--------------------------------------------------------------
>10289_10289_6_BRIP1-SPAG9_BRIP1_chr17_59934419_ENST00000259008_SPAG9_chr17_49157065_ENST00000505279_length(transcript)=4925nt_BP=647nt
AATTCGTCTCGGGTTGTGTGGTTGAGGGGTCTGGTGGGTCGAGGAAAGGTAACGGCGGCCCCAGTCCTGCACACAAGGCCGGGGAAGTAG
CAGCACCCCCAGGAAGAGGGAGGAGGAAGGGCTCGTGCCCTTTCTTCTCTTCCAGGGCTCCGCTTTATTTGCTCTCAGAAGTCGGTTTCC
TTTCCTTTTCTTCAGTGAATCGGAGCTCAGAGCGTTGCTTCGGTTTCCCTCCAGACAGTTAGGAATCTGAAATAAACAGGAAAGCACTAT
GTCTTCAATGTGGTCTGAATATACAATTGGTGGGGTGAAGATTTACTTTCCTTATAAAGCTTACCCGTCACAGCTTGCTATGATGAATTC
TATTCTCAGAGGATTAAACAGCAAGCAACATTGTTTGTTGGAGAGTCCCACAGGAAGTGGAAAAAGCTTAGCCTTACTTTGTTCTGCTTT
AGCATGGCAACAATCTCTTAGTGGGAAACCAGCAGATGAGGGCGTAAGTGAAAAAGCTGAAGTACAATTGTCATGTTGTTGTGCATGCCA
TTCAAAGGATTTTACAAACAATGACATGAACCAAGGAACTTCACGTCATTTCAACTATCCAAGCACACCACCTTCTGAAAGAAATGGCAC
TTCATCAACTTGTCAAGAAATTCATTGAATTTGAAGACTCTCAAGAACAGGAAAAAAAGGACTTACAGACCCGAGTGGAATCTTTAGAAT
CTCAAACAAGACAACTTGAGCTGAAAGCGAAAAACTATGCTGACCAGATTAGCAGACTTGAAGAAAGAGAAGCAGAACTGAAGAAGGAAT
ATAATGCATTACATCAAAGACACACTGAGATGATCCATAATTATATGGAACATTTAGAAAGAACAAAACTTCATCAGCTCTCAGGGAGTG
ATCAACTAGAATCCACAGCTCATAGTAGAATTAGAAAAGAACGCCCTATATCATTAGGAATTTTCCCATTACCTGCTGGAGATGGATTGC
TTACACCTGATGCTCAGAAAGGAGGAGAGACCCCTGGATCTGAGCAATGGAAATTTCAGGAATTAAGTCAACCACGTTCTCATACCAGCC
TGAAGGATGAGCTTTCTGATGTTAGCCAAGGCGGATCTAAAGCTACCACTCCAGCATCAACAGCTAATTCAGATGTGGCAACAATTCCTA
CTGATACTCCCTTAAAGGAAGAAAACGAAGGATTTGTGAAGGTTACAGATGCGCCAAATAAATCAGAGATAAGCAAACACATTGAAGTAC
AGGTAGCCCAGGAAACTAGAAATGTATCTACTGGCTCTGCTGAAAATGAAGAAAAGTCAGAAGTTCAAGCAATCATCGAATCTACTCCTG
AGCTGGATATGGACAAAGATCTCAGTGGATATAAAGGTTCAAGCACTCCCACCAAAGGCATAGAGAACAAAGCTTTTGATCGCAATACAG
AATCTCTCTTTGAAGAACTGTCTTCAGCTGGCTCAGGCCTAATAGGAGATGTGGATGAAGGAGCAGATTTACTAGGAATGGGTCGGGAAG
TTGAGAATCTTATATTAGAAAATACACAACTGTTGGAAACCAAAAATGCTTTGAACATAGTGAAGAATGATTTGATAGCAAAAGTGGATG
AACTGACCTGTGAGAAAGATGTGCTGCAAGGGGAATTGGAGGCTGTGAAGCAAGCCAAACTGAAACTAGAGGAAAAGAACAGAGAATTGG
AGGAAGAGCTTAGGAAAGCTCGGGCAGAAGCTGAAGATGCAAGGCAAAAAGCAAAAGATGACGATGATAGTGATATTCCCACAGCCCAGA
GGAAACGGTTTACTAGAGTAGAAATGGCCCGTGTTCTCATGGAGCGAAACCAGTATAAAGAGAGATTGATGGAGCTTCAGGAAGCTGTTC
GATGGACAGAGATGATTCGGGCATCACGAGAAAATCCAGCCATGCAGGAAAAAAAAAGGTCAAGCATTTGGCAGTTTGTGCCAACTCGTT
TCAGCCGACTTTTCAGCTCCTCAAGTAACACGACTAAGAAGCCTGAACCACCTGTTAATCTGAAGTACAATGCACCCACGTCTCATGTTA
CTCCGTCCGTCAAGAAAAGAAGCAGCACCTTATCTCAGCTCCCTGGGGATAAGTCCAAAGCCTTTGATTTCCTTAGTGAAGAAACTGAAG
CTAGTTTAGCCTCACGCAGAGAACAAAAGAGAGAGCAGTATCGTCAGGTAAAAGCACATGTTCAGAAGGAAGACGGTAGAGTGCAGGCTT
TTGGCTGGAGTCTGCCTCAGAAGTACAAACAGGTAACCAATGGTCAAGGTGAAAATAAGATGAAAAATTTACCTGTGCCTGTCTATCTCA
GACCTCTGGATGAAAAAGATACATCAATGAAGCTGTGGTGTGCTGTTGGAGTCAATTTATCTGGTGGGAAGACCAGAGATGGTGGTTCTG
TTGTTGGAGCAAGTGTATTTTACAAGGATGTTGCTGGTTTGGATACAGAAGGCAGTAAACAGCGAAGTGCCTCTCAGAGTAGTTTAGATA
AGTTAGATCAGGAACTTAAGGAACAGCAGAAGGAGTTAAAAAATCAAGAAGAATTATCCAGTCTAGTTTGGATCTGTACCAGCACTCATT
CGGCTACAAAAGTTCTTATTATTGATGCTGTTCAACCTGGCAACATCCTAGACAGTTTCACTGTTTGCAACTCTCATGTTCTGTGCATTG
CAAGTGTGCCAGGTGCACGAGAAACAGACTACCCTGCAGGAGAAGATCTTTCAGAATCTGGTCAGGTAGACAAAGCATCTTTATGTGGAA
GTATGACAAGCAACAGCTCAGCAGAGACAGACAGCCTGTTAGGAGGCATCACAGTGGTTGGTTGTTCTGCAGAAGGTGTGACGGGAGCTG
CCACTTCCCCTAGTACAAATGGTGCTTCTCCAGTGATGGATAAACCACCAGAAATGGAAGCAGAAAATAGTGAGGTTGATGAAAATGTTC
CAACAGCAGAAGAAGCAACTGAAGCTACAGAAGGGAATGCGGGGTCAGCTGAAGACACAGTGGACATCTCCCAAACTGGCGTCTACACAG
AGCATGTCTTTACAGATCCTTTGGGAGTTCAGATCCCAGAAGACCTCTCCCCAGTGTATCAGTCGAGCAATGACTCAGATGCATATAAAG
ATCAAATATCAGTACTGCCAAATGAACAAGACTTGGTGAGAGAAGAAGCCCAGAAAATGAGTAGTCTTTTACCAACTATGTGGCTTGGAG
CTCAAAATGGCTGTTTGTATGTCCATTCATCTGTAGCCCAGTGGAGGAAATGTCTCCATTCCATTAAACTTAAAGATTCGATTCTCAGTA
TTGTACACGTGAAGGGAATCGTGTTAGTAGCCCTGGCTGACGGCACCCTTGCAATCTTTCACAGAGGAGTGGATGGGCAGTGGGATTTGT
CAAACTATCACCTCTTAGACCTTGGACGGCCTCATCATTCCATCCGTTGCATGACTGTGGTACATGACAAAGTCTGGTGTGGCTATAGGA
ACAAAATCTATGTGGTGCAGCCAAAGGCCATGAAAATAGAGAAATCTTTTGATGCACATCCCAGGAAGGAGAGCCAAGTGCGACAGCTTG
CGTGGGTGGGGGATGGCGTGTGGGTCTCCATTCGCTTGGATTCTACGCTCCGTCTCTATCATGCACACACTTATCAACATCTACAGGATG
TGGACATTGAGCCTTATGTAAGCAAAATGTTAGGTACTGGAAAACTGGGCTTCTCTTTTGTGAGAATTACAGCTCTTATGGTGTCTTGTA
ATCGTTTGTGGGTGGGGACAGGAAATGGTGTCATTATCTCCATCCCATTGACAGAAACAAATAAAACCTCAGGTGTACCAGGAAATCGTC
CTGGAAGTGTAATCCGTGTATATGGTGATGAAAACAGTGATAAAGTGACTCCAGGGACATTTATACCCTATTGTTCAATGGCACATGCAC
AGCTTTGCTTCCATGGGCACCGGGATGCTGTGAAATTCTTTGTGGCAGTCCCAGGTCAAGTCATCAGCCCACAAAGTAGCAGTAGTGGCA
CGGATCTGACGGGTGACAAAGCAGGGCCATCTGCACAGGAGCCTGGTAGTCAGACGCCCTTGAAGTCTATGCTTGTCATCAGTGGAGGAG
AGGGCTACATCGACTTCCGAATGGGTGATGAAGGTGGAGAATCAGAACTTCTTGGAGAGGATCTTCCACTTGAACCTTCTGTCACCAAAG
CAGAAAGGAGTCACTTGATAGTGTGGCAAGTGATGTATGGCAATGAGTGAGCCCATGGGAAACAGGTGGAGATGGGGAAGCCGTCTCTTC
TGCATGGTTTATTTTCCCTCTATCCTTTTATTTAATGCTCTTTTGTGAGATAAGTTTCACCACATAATGTGTGAGCATTTTTTCCTGTTA
ACTTTATATTACAAAATCCGTTCTACCATAACAATACAGAGGAACTAGCTGTGTTACTGCACCAGTGTTATAGGTAACTTCAGTATATTA
TGAACAAATCAAAGAATGTTTACTTCCTGCAAACTGGTGAATTATAGAAAGCAATCCAGATGTGGTTTACTCTGCCACAGTCTAATGTCA
TTCACTTCATTTGATGGGGTCACTTGTTAGCTGTCACTAATAATGGAATTAATGGGAAACACTTGATAAATGAAACTGTACCGTTAAATA
CAATAGCTGAGTTTTCCCCAGTGTATTGTAAAATTGACACACACTAATACAAGATGGATTATCAGGATGTATCTAAATGTCCCGAGAGGG
TTAAAAGCTAACTGTAAATTACTTTAACTTTCACTTTCAAATCTGACAAATCTTGTTTATATGGTATATAAAACTTTGTTTTCATCAGAT

>10289_10289_6_BRIP1-SPAG9_BRIP1_chr17_59934419_ENST00000259008_SPAG9_chr17_49157065_ENST00000505279_length(amino acids)=1221AA_BP=11
MKEMALHQLVKKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH
QLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKDELSDVSQGGSKATTPASTANSD
VATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKA
FDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEE
KNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQ
FVPTRFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKED
GRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSAS
QSSLDKLDQELKEQQKELKNQEELSSLVWICTSTHSATKVLIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDK
ASLCGSMTSNSSAETDSLLGGITVVGCSAEGVTGAATSPSTNGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAGSAEDTVDISQ
TGVYTEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVLPNEQDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLK
DSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKES
QVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSG
VPGNRPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQTPLKSML

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BRIP1-SPAG9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneBRIP1chr17:59934418chr17:49157065ENST00000259008-420888_1063126.333333333333331250.0BRCA1
HgeneBRIP1chr17:59934419chr17:49157065ENST00000259008-420888_1063126.333333333333331250.0BRCA1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BRIP1-SPAG9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BRIP1-SPAG9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBRIP1C1836860FANCONI ANEMIA, COMPLEMENTATION GROUP J9CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneBRIP1C0006142Malignant neoplasm of breast4CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneBRIP1C0015625Fanconi Anemia3CTD_human;GENOMICS_ENGLAND
HgeneBRIP1C0023418leukemia1CGI;GENOMICS_ENGLAND
HgeneBRIP1C0023465Acute monocytic leukemia1GENOMICS_ENGLAND
HgeneBRIP1C0023467Leukemia, Myelocytic, Acute1CGI;GENOMICS_ENGLAND
HgeneBRIP1C0030312Pancytopenia1GENOMICS_ENGLAND
HgeneBRIP1C0265219Miller Dieker syndrome1GENOMICS_ENGLAND
HgeneBRIP1C0496956Neoplasm of uncertain or unknown behavior of breast1CGI;GENOMICS_ENGLAND
HgeneBRIP1C0677776Hereditary Breast and Ovarian Cancer Syndrome1ORPHANET
HgeneBRIP1C0919267ovarian neoplasm1CTD_human
HgeneBRIP1C1140680Malignant neoplasm of ovary1CTD_human;UNIPROT
HgeneBRIP1C1855710Bone marrow hypocellularity1GENOMICS_ENGLAND
HgeneBRIP1C3463824MYELODYSPLASTIC SYNDROME1GENOMICS_ENGLAND
HgeneBRIP1C4228778Abnormality of radial ray1GENOMICS_ENGLAND