![]() |
||||||
|
![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:DTNBP1-DNAH8 (FusionGDB2 ID:HG84062TG1769) |
Fusion Gene Summary for DTNBP1-DNAH8 |
![]() |
Fusion gene information | Fusion gene name: DTNBP1-DNAH8 | Fusion gene ID: hg84062tg1769 | Hgene | Tgene | Gene symbol | DTNBP1 | DNAH8 | Gene ID | 84062 | 1769 |
Gene name | dystrobrevin binding protein 1 | dynein axonemal heavy chain 8 | |
Synonyms | BLOC1S8|DBND|HPS7|My031|SDY | ATPase|hdhc9 | |
Cytomap | ('DTNBP1')('DNAH8') 6p22.3 | 6p21.2 | |
Type of gene | protein-coding | protein-coding | |
Description | dysbindinBLOC-1 subunit 8Hermansky-Pudlak syndrome 7 proteinbiogenesis of lysosomal organelles complex-1, subunit 8biogenesis of lysosome-related organelles complex 1 subunit 8dysbindin-1 | dynein heavy chain 8, axonemalaxonemal beta dynein heavy chain 8ciliary dynein heavy chain 8dynein, axonemal, heavy polypeptide 8 | |
Modification date | 20200313 | 20200327 | |
UniProtAcc | . | Q96JB1 | |
Ensembl transtripts involved in fusion gene | ENST00000338950, ENST00000344537, ENST00000355917, ENST00000462989, | ||
Fusion gene scores | * DoF score | 6 X 4 X 4=96 | 11 X 13 X 7=1001 |
# samples | 6 | 13 | |
** MAII score | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/1001*10)=-2.94485844580754 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DTNBP1 [Title/Abstract] AND DNAH8 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | DTNBP1(15615498)-DNAH8(38979991), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DTNBP1 | GO:0031175 | neuron projection development | 16980328 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BRCA | TCGA-D8-A1JP-01A | DTNBP1 | chr6 | 15615498 | - | DNAH8 | chr6 | 38979991 | + |
Top |
Fusion Gene ORF analysis for DTNBP1-DNAH8 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000338950 | ENST00000359357 | DTNBP1 | chr6 | 15615498 | - | DNAH8 | chr6 | 38979991 | + |
5CDS-intron | ENST00000338950 | ENST00000441566 | DTNBP1 | chr6 | 15615498 | - | DNAH8 | chr6 | 38979991 | + |
5CDS-intron | ENST00000338950 | ENST00000449981 | DTNBP1 | chr6 | 15615498 | - | DNAH8 | chr6 | 38979991 | + |
5CDS-intron | ENST00000344537 | ENST00000359357 | DTNBP1 | chr6 | 15615498 | - | DNAH8 | chr6 | 38979991 | + |
5CDS-intron | ENST00000344537 | ENST00000441566 | DTNBP1 | chr6 | 15615498 | - | DNAH8 | chr6 | 38979991 | + |
5CDS-intron | ENST00000344537 | ENST00000449981 | DTNBP1 | chr6 | 15615498 | - | DNAH8 | chr6 | 38979991 | + |
5CDS-intron | ENST00000355917 | ENST00000359357 | DTNBP1 | chr6 | 15615498 | - | DNAH8 | chr6 | 38979991 | + |
5CDS-intron | ENST00000355917 | ENST00000441566 | DTNBP1 | chr6 | 15615498 | - | DNAH8 | chr6 | 38979991 | + |
5CDS-intron | ENST00000355917 | ENST00000449981 | DTNBP1 | chr6 | 15615498 | - | DNAH8 | chr6 | 38979991 | + |
intron-intron | ENST00000462989 | ENST00000359357 | DTNBP1 | chr6 | 15615498 | - | DNAH8 | chr6 | 38979991 | + |
intron-intron | ENST00000462989 | ENST00000441566 | DTNBP1 | chr6 | 15615498 | - | DNAH8 | chr6 | 38979991 | + |
intron-intron | ENST00000462989 | ENST00000449981 | DTNBP1 | chr6 | 15615498 | - | DNAH8 | chr6 | 38979991 | + |
![]() |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
![]() |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
Top |
Fusion Genomic Features for DTNBP1-DNAH8 |
![]() |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
DTNBP1 | chr6 | 15615497 | - | DNAH8 | chr6 | 38979990 | + | 0.000215966 | 0.99978405 |
DTNBP1 | chr6 | 15615497 | - | DNAH8 | chr6 | 38979990 | + | 0.000215966 | 0.99978405 |
![]() |
![]() |
Top |
Fusion Protein Features for DTNBP1-DNAH8 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:15615498/:38979991) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
![]() |
![]() |
Hgene | Tgene |
. | DNAH8 |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Force generating protein component of the outer dynein arms (ODAs) in the sperm flagellum. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly. {ECO:0000250, ECO:0000305|PubMed:31178125}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
Fusion Gene Sequence for DTNBP1-DNAH8 |
![]() |
Top |
Fusion Gene PPI Analysis for DTNBP1-DNAH8 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for DTNBP1-DNAH8 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for DTNBP1-DNAH8 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DTNBP1 | C0005586 | Bipolar Disorder | 5 | PSYGENET |
Hgene | DTNBP1 | C0041696 | Unipolar Depression | 5 | PSYGENET |
Hgene | DTNBP1 | C1269683 | Major Depressive Disorder | 5 | PSYGENET |
Hgene | DTNBP1 | C0011570 | Mental Depression | 4 | PSYGENET |
Hgene | DTNBP1 | C0011581 | Depressive disorder | 4 | PSYGENET |
Hgene | DTNBP1 | C0525045 | Mood Disorders | 3 | PSYGENET |
Hgene | DTNBP1 | C0270458 | Severe major depression with psychotic features | 2 | PSYGENET |
Hgene | DTNBP1 | C3279756 | HERMANSKY-PUDLAK SYNDROME 7 | 2 | GENOMICS_ENGLAND;ORPHANET |
Hgene | DTNBP1 | C0004930 | Behavior Disorders | 1 | CTD_human |
Hgene | DTNBP1 | C0004936 | Mental disorders | 1 | CTD_human |
Hgene | DTNBP1 | C0033937 | Psychoses, Drug | 1 | PSYGENET |
Hgene | DTNBP1 | C0036341 | Schizophrenia | 1 | CTD_human |
Hgene | DTNBP1 | C0376338 | Diagnosis, Psychiatric | 1 | CTD_human |
Hgene | DTNBP1 | C4046029 | Mental Disorders, Severe | 1 | CTD_human |
Tgene | C0005586 | Bipolar Disorder | 4 | PSYGENET | |
Tgene | C0338831 | Manic | 2 | PSYGENET | |
Tgene | C0009171 | Cocaine Abuse | 1 | CTD_human | |
Tgene | C0013146 | Drug abuse | 1 | CTD_human | |
Tgene | C0013170 | Drug habituation | 1 | CTD_human | |
Tgene | C0013222 | Drug Use Disorders | 1 | CTD_human | |
Tgene | C0029231 | Organic Mental Disorders, Substance-Induced | 1 | CTD_human | |
Tgene | C0038580 | Substance Dependence | 1 | CTD_human | |
Tgene | C0038586 | Substance Use Disorders | 1 | CTD_human | |
Tgene | C0236736 | Cocaine-Related Disorders | 1 | CTD_human | |
Tgene | C0236969 | Substance-Related Disorders | 1 | CTD_human | |
Tgene | C0600427 | Cocaine Dependence | 1 | CTD_human | |
Tgene | C0740858 | Substance abuse problem | 1 | CTD_human | |
Tgene | C1456784 | Paranoia | 1 | CTD_human | |
Tgene | C1510472 | Drug Dependence | 1 | CTD_human | |
Tgene | C4316881 | Prescription Drug Abuse | 1 | CTD_human |