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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANKRD27-PEPD (FusionGDB2 ID:HG84079TG5184)

Fusion Gene Summary for ANKRD27-PEPD

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD27-PEPD
Fusion gene ID: hg84079tg5184
HgeneTgene
Gene symbol

ANKRD27

PEPD

Gene ID

84079

5184

Gene nameankyrin repeat domain 27peptidase D
SynonymsPP12899|VARPPROLIDASE
Cytomap('ANKRD27')('PEPD')

19q13.11

19q13.11

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat domain-containing protein 27VPS9 domain-containing proteinVPS9-ankyrin-repeat proteinVps9 domain and ankyrin-repeat-containing proteinankyrin repeat domain 27 (VPS9 domain)xaa-Pro dipeptidaseX-Pro dipeptidaseaminoacyl-L-proline hydrolaseimidodipeptidaseproline dipeptidasetesticular tissue protein Li 138
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000306065, ENST00000587352, 
Fusion gene scores* DoF score14 X 14 X 8=156818 X 11 X 13=2574
# samples 1623
** MAII scorelog2(16/1568*10)=-3.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(23/2574*10)=-3.48430628727633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANKRD27 [Title/Abstract] AND PEPD [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANKRD27(33118989)-PEPD(33902655), # samples:3
Anticipated loss of major functional domain due to fusion event.ANKRD27-PEPD seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD27-PEPD seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD27-PEPD seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD27-PEPD seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANKRD27

GO:0035544

negative regulation of SNARE complex assembly

24856514

HgeneANKRD27

GO:0045022

early endosome to late endosome transport

16525121


check buttonFusion gene breakpoints across ANKRD27 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PEPD (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-EY-A4KR-01AANKRD27chr19

33118989

-PEPDchr19

33902655

-
ChimerDB4UCECTCGA-EY-A4KRANKRD27chr19

33118988

-PEPDchr19

33902655

-


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Fusion Gene ORF analysis for ANKRD27-PEPD

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000306065ENST00000591968ANKRD27chr19

33118989

-PEPDchr19

33902655

-
5CDS-intronENST00000306065ENST00000591968ANKRD27chr19

33118988

-PEPDchr19

33902655

-
In-frameENST00000306065ENST00000244137ANKRD27chr19

33118989

-PEPDchr19

33902655

-
In-frameENST00000306065ENST00000244137ANKRD27chr19

33118988

-PEPDchr19

33902655

-
In-frameENST00000306065ENST00000397032ANKRD27chr19

33118989

-PEPDchr19

33902655

-
In-frameENST00000306065ENST00000397032ANKRD27chr19

33118988

-PEPDchr19

33902655

-
In-frameENST00000306065ENST00000436370ANKRD27chr19

33118989

-PEPDchr19

33902655

-
In-frameENST00000306065ENST00000436370ANKRD27chr19

33118988

-PEPDchr19

33902655

-
intron-3CDSENST00000587352ENST00000244137ANKRD27chr19

33118989

-PEPDchr19

33902655

-
intron-3CDSENST00000587352ENST00000244137ANKRD27chr19

33118988

-PEPDchr19

33902655

-
intron-3CDSENST00000587352ENST00000397032ANKRD27chr19

33118989

-PEPDchr19

33902655

-
intron-3CDSENST00000587352ENST00000397032ANKRD27chr19

33118988

-PEPDchr19

33902655

-
intron-3CDSENST00000587352ENST00000436370ANKRD27chr19

33118989

-PEPDchr19

33902655

-
intron-3CDSENST00000587352ENST00000436370ANKRD27chr19

33118988

-PEPDchr19

33902655

-
intron-intronENST00000587352ENST00000591968ANKRD27chr19

33118989

-PEPDchr19

33902655

-
intron-intronENST00000587352ENST00000591968ANKRD27chr19

33118988

-PEPDchr19

33902655

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000306065ANKRD27chr1933118989-ENST00000244137PEPDchr1933902655-271515791591799546
ENST00000306065ANKRD27chr1933118989-ENST00000397032PEPDchr1933902655-268515791591799546
ENST00000306065ANKRD27chr1933118989-ENST00000436370PEPDchr1933902655-264115791591799546
ENST00000306065ANKRD27chr1933118988-ENST00000244137PEPDchr1933902655-271515791591799546
ENST00000306065ANKRD27chr1933118988-ENST00000397032PEPDchr1933902655-268515791591799546
ENST00000306065ANKRD27chr1933118988-ENST00000436370PEPDchr1933902655-264115791591799546

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000306065ENST00000244137ANKRD27chr1933118989-PEPDchr1933902655-0.0178591570.9821408
ENST00000306065ENST00000397032ANKRD27chr1933118989-PEPDchr1933902655-0.0189077630.9810922
ENST00000306065ENST00000436370ANKRD27chr1933118989-PEPDchr1933902655-0.0182574170.9817426
ENST00000306065ENST00000244137ANKRD27chr1933118988-PEPDchr1933902655-0.0178591570.9821408
ENST00000306065ENST00000397032ANKRD27chr1933118988-PEPDchr1933902655-0.0189077630.9810922
ENST00000306065ENST00000436370ANKRD27chr1933118988-PEPDchr1933902655-0.0182574170.9817426

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Fusion Genomic Features for ANKRD27-PEPD


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ANKRD27-PEPD


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:33118989/chr19:33902655)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD27chr19:33118988chr19:33902655ENST00000306065-1529233_3714731051.0DomainVPS9
HgeneANKRD27chr19:33118989chr19:33902655ENST00000306065-1529233_3714731051.0DomainVPS9
HgeneANKRD27chr19:33118988chr19:33902655ENST00000306065-15291_3724731051.0RegionSufficient for GEF activity towards RAB21
HgeneANKRD27chr19:33118989chr19:33902655ENST00000306065-15291_3724731051.0RegionSufficient for GEF activity towards RAB21
HgeneANKRD27chr19:33118988chr19:33902655ENST00000306065-1529396_4264731051.0RepeatNote=ANK 1
HgeneANKRD27chr19:33118989chr19:33902655ENST00000306065-1529396_4264731051.0RepeatNote=ANK 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD27chr19:33118988chr19:33902655ENST00000306065-1529462_4914731051.0RepeatNote=ANK 2
HgeneANKRD27chr19:33118988chr19:33902655ENST00000306065-1529495_5244731051.0RepeatNote=ANK 3
HgeneANKRD27chr19:33118988chr19:33902655ENST00000306065-1529528_5604731051.0RepeatNote=ANK 4
HgeneANKRD27chr19:33118988chr19:33902655ENST00000306065-1529564_5934731051.0RepeatNote=ANK 5
HgeneANKRD27chr19:33118988chr19:33902655ENST00000306065-1529597_6274731051.0RepeatNote=ANK 6
HgeneANKRD27chr19:33118988chr19:33902655ENST00000306065-1529668_6984731051.0RepeatNote=ANK 7
HgeneANKRD27chr19:33118988chr19:33902655ENST00000306065-1529743_7724731051.0RepeatNote=ANK 8
HgeneANKRD27chr19:33118988chr19:33902655ENST00000306065-1529776_8054731051.0RepeatNote=ANK 9
HgeneANKRD27chr19:33118988chr19:33902655ENST00000306065-1529809_8384731051.0RepeatNote=ANK 10
HgeneANKRD27chr19:33118988chr19:33902655ENST00000306065-1529842_8714731051.0RepeatNote=ANK 11
HgeneANKRD27chr19:33118989chr19:33902655ENST00000306065-1529462_4914731051.0RepeatNote=ANK 2
HgeneANKRD27chr19:33118989chr19:33902655ENST00000306065-1529495_5244731051.0RepeatNote=ANK 3
HgeneANKRD27chr19:33118989chr19:33902655ENST00000306065-1529528_5604731051.0RepeatNote=ANK 4
HgeneANKRD27chr19:33118989chr19:33902655ENST00000306065-1529564_5934731051.0RepeatNote=ANK 5
HgeneANKRD27chr19:33118989chr19:33902655ENST00000306065-1529597_6274731051.0RepeatNote=ANK 6
HgeneANKRD27chr19:33118989chr19:33902655ENST00000306065-1529668_6984731051.0RepeatNote=ANK 7
HgeneANKRD27chr19:33118989chr19:33902655ENST00000306065-1529743_7724731051.0RepeatNote=ANK 8
HgeneANKRD27chr19:33118989chr19:33902655ENST00000306065-1529776_8054731051.0RepeatNote=ANK 9
HgeneANKRD27chr19:33118989chr19:33902655ENST00000306065-1529809_8384731051.0RepeatNote=ANK 10
HgeneANKRD27chr19:33118989chr19:33902655ENST00000306065-1529842_8714731051.0RepeatNote=ANK 11


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Fusion Gene Sequence for ANKRD27-PEPD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4650_4650_1_ANKRD27-PEPD_ANKRD27_chr19_33118988_ENST00000306065_PEPD_chr19_33902655_ENST00000244137_length(transcript)=2715nt_BP=1579nt
GGAGTAAGGGGTGGGCTATAGGGCCAGATCGCCGCGCGAGGGTGGTGGGCATCGAGGTCCCAGCAGCGGACGAGGGAGGTGCCGCCGTCG
CCCAGGATGGGCTGGGAATGAAGCGATGTAGCCTTTTAAGAGATTTGCTCTGACCCATCTGAAGTCCATATGGCTCTGTATGATGAAGAC
CTCCTGAAAAATCCTTTCTATCTGGCTCTGCAAAAGTGCCGCCCTGACTTGTGCAGCAAAGTGGCCCAAATCCATGGCATTGTCTTAGTA
CCCTGCAAAGGAAGCCTGTCGAGCAGCATCCAGTCTACTTGTCAGTTTGAGTCCTACATTTTGATACCTGTGGAAGAGCATTTTCAGACC
TTAAATGGAAAGGATGTCTTTATTCAAGGGAACAGGATTAAATTAGGAGCTGGTTTTGCCTGTCTTCTCTCAGTGCCCATTCTCTTTGAA
GAAACTTTCTACAATGAAAAAGAAGAGAGTTTCAGCATCCTGTGTATAGCCCATCCTTTGGAAAAGAGAGAGAGTTCAGAAGAGCCTTTG
GCACCCTCAGATCCCTTTTCCCTGAAAACCATTGAAGATGTGAGAGAGTTCTTGGGAAGACACTCCGAGCGATTTGACAGGAACATCGCC
TCTTTCCATCGAACATTCCGAGAATGCGAGAGAAAGAGCCTCCGTCACCACATAGACTCAGCGAATGCTCTCTACACCAAATGCCTCCAG
CAGCTTCTGAGGGACTCTCACCTGAAAATGCTCGCCAAGCAGGAGGCCCAGATGAACCTGATGAAGCAGGCAGTGGAGATATACGTCCAT
CATGAAATTTACAACCTGATCTTTAAATACGTGGGGACCATGGAGGCAAGTGAGGATGCGGCCTTTAACAAAATCACAAGAAGCCTTCAA
GATCTTCAGCAGAAAGATATTGGTGTGAAACCGGAGTTCAGCTTTAACATACCTCGTGCCAAAAGAGAGCTGGCTCAGCTGAACAAATGC
ACCTCCCCACAGCAGAAGCTTGTCTGCTTGCGAAAAGTGGTGCAGCTCATTACACAGTCTCCAAGCCAGAGAGTGAACCTGGAGACCATG
TGTGCTGATGATCTGCTATCAGTCCTGTTATACTTGCTTGTGAAAACGGAGATCCCTAATTGGATGGCAAATTTGAGTTACATCAAAAAC
TTCAGGTTTAGCAGCTTGGCAAAGGATGAACTGGGATACTGCCTGACCTCATTCGAAGCTGCCATTGAATATATTCGGCAAGGAAGCCTC
TCTGCTAAACCCCCTGAGTCTGAGGGATTTGGAGACAGGCTGTTCCTTAAGCAGAGAATGAGCTTACTCTCTCAGATGACTTCGTCTCCC
ACCGACTGCCTGTTTAAGCACATTGCATCAGGTAACCAGAAAGAAGTGGAGAGACTTCTGAGCCAAGAGGACCATGATAAAGATACCGTC
CAAAAGATGTGTCACCCTCTCTGCTTCTGCGATGACTGTGAGAAACTCGTCTCTGGGAGGTTGAATGATCCCTCAGTTGTCACTCCATTC
TCCAGAGACGACAGGGGGCACACCCCTCTCCATGTGGCTGCTGTCTGTGTGGTGAGAACTCAGCCGTGCTACACTACGGACACGCCGGAG
CTCCCAACGACCGAACGATCCAGAATGGGGATATGTGCCTGTTCGACATGGGCGGTGAGTATTACTGCTTCGCTTCCGACATCACCTGCT
CCTTTCCCGCCAACGGCAAGTTCACTGCAGACCAGAAGGCCGTCTATGAGGCAGTGCTGCGGAGCTCCCGTGCCGTCATGGGTGCCATGA
AGCCAGGTGTCTGGTGGCCTGACATGCACCGCCTGGCTGACCGCATCCACCTGGAGGAGCTGGCCCACATGGGCATCCTGAGCGGCAGCG
TGGACGCCATGGTCCAGGCTCACCTGGGGGCCGTGTTTATGCCTCACGGGCTTGGCCACTTCCTGGGCATTGACGTGCACGACGTGGGAG
GCTACCCAGAGGGCGTGGAGCGCATCGACGAGCCCGGCCTGCGGAGCCTGCGCACTGCACGGCACCTGCAGCCAGGCATGGTGCTCACCG
TGGAGCCGGGCATCTACTTCATCGACCACCTCCTGGATGAGGCCCTGGCGGACCCGGCCCGCGCCTCCTTCCTTAACCGCGAGGTCCTGC
AGCGCTTTCGCGGTTTTGGCGGGGTCCGCATCGAGGAGGACGTCGTGGTGACTGACAGCGGCATAGAGCTGCTGACCTGCGTGCCCCGCA
CTGTGGAAGAGATTGAAGCATGCATGGCAGGCTGTGACAAGGCCTTTACCCCCTTCTCTGGCCCCAAGTAGAGCCAGCCAGAAATCCCAG
CGCACCTGGGGGCCTGGCCTTGCAACCTCTTTTCGTGATGGGCAGCCTGCTGGTCAGCACTCCAGTAGCGAGAGACGGCACCCAGAATCA
GATCCCAGCTTCGGCATTTGATCAGACCAAACAGTGCTGTTTCCCGGGGAGGAAACACTTTTTTAATTACCCTTTTGCAGGCTCCCACCT
TTAATCTGTTTTATACCTTGCTTATTAAATGAGCGACTTAAAATGATTGAAAATAATGCTGTTCTTTAGTAGCAACTAAAATGTGTCTTG
CTGTCATTTATATTCCTTTTCCCAGGAAAGAAGCATTTCTGATACTTTCTGTCAAAAATCAATATGCAGAATGGCATTTGCAATAAAAGG

>4650_4650_1_ANKRD27-PEPD_ANKRD27_chr19_33118988_ENST00000306065_PEPD_chr19_33902655_ENST00000244137_length(amino acids)=546AA_BP=473
MALYDEDLLKNPFYLALQKCRPDLCSKVAQIHGIVLVPCKGSLSSSIQSTCQFESYILIPVEEHFQTLNGKDVFIQGNRIKLGAGFACLL
SVPILFEETFYNEKEESFSILCIAHPLEKRESSEEPLAPSDPFSLKTIEDVREFLGRHSERFDRNIASFHRTFRECERKSLRHHIDSANA
LYTKCLQQLLRDSHLKMLAKQEAQMNLMKQAVEIYVHHEIYNLIFKYVGTMEASEDAAFNKITRSLQDLQQKDIGVKPEFSFNIPRAKRE
LAQLNKCTSPQQKLVCLRKVVQLITQSPSQRVNLETMCADDLLSVLLYLLVKTEIPNWMANLSYIKNFRFSSLAKDELGYCLTSFEAAIE
YIRQGSLSAKPPESEGFGDRLFLKQRMSLLSQMTSSPTDCLFKHIASGNQKEVERLLSQEDHDKDTVQKMCHPLCFCDDCEKLVSGRLND
PSVVTPFSRDDRGHTPLHVAAVCVVRTQPCYTTDTPELPTTERSRMGICACSTWAVSITASLPTSPAPFPPTASSLQTRRPSMRQCCGAP

--------------------------------------------------------------
>4650_4650_2_ANKRD27-PEPD_ANKRD27_chr19_33118988_ENST00000306065_PEPD_chr19_33902655_ENST00000397032_length(transcript)=2685nt_BP=1579nt
GGAGTAAGGGGTGGGCTATAGGGCCAGATCGCCGCGCGAGGGTGGTGGGCATCGAGGTCCCAGCAGCGGACGAGGGAGGTGCCGCCGTCG
CCCAGGATGGGCTGGGAATGAAGCGATGTAGCCTTTTAAGAGATTTGCTCTGACCCATCTGAAGTCCATATGGCTCTGTATGATGAAGAC
CTCCTGAAAAATCCTTTCTATCTGGCTCTGCAAAAGTGCCGCCCTGACTTGTGCAGCAAAGTGGCCCAAATCCATGGCATTGTCTTAGTA
CCCTGCAAAGGAAGCCTGTCGAGCAGCATCCAGTCTACTTGTCAGTTTGAGTCCTACATTTTGATACCTGTGGAAGAGCATTTTCAGACC
TTAAATGGAAAGGATGTCTTTATTCAAGGGAACAGGATTAAATTAGGAGCTGGTTTTGCCTGTCTTCTCTCAGTGCCCATTCTCTTTGAA
GAAACTTTCTACAATGAAAAAGAAGAGAGTTTCAGCATCCTGTGTATAGCCCATCCTTTGGAAAAGAGAGAGAGTTCAGAAGAGCCTTTG
GCACCCTCAGATCCCTTTTCCCTGAAAACCATTGAAGATGTGAGAGAGTTCTTGGGAAGACACTCCGAGCGATTTGACAGGAACATCGCC
TCTTTCCATCGAACATTCCGAGAATGCGAGAGAAAGAGCCTCCGTCACCACATAGACTCAGCGAATGCTCTCTACACCAAATGCCTCCAG
CAGCTTCTGAGGGACTCTCACCTGAAAATGCTCGCCAAGCAGGAGGCCCAGATGAACCTGATGAAGCAGGCAGTGGAGATATACGTCCAT
CATGAAATTTACAACCTGATCTTTAAATACGTGGGGACCATGGAGGCAAGTGAGGATGCGGCCTTTAACAAAATCACAAGAAGCCTTCAA
GATCTTCAGCAGAAAGATATTGGTGTGAAACCGGAGTTCAGCTTTAACATACCTCGTGCCAAAAGAGAGCTGGCTCAGCTGAACAAATGC
ACCTCCCCACAGCAGAAGCTTGTCTGCTTGCGAAAAGTGGTGCAGCTCATTACACAGTCTCCAAGCCAGAGAGTGAACCTGGAGACCATG
TGTGCTGATGATCTGCTATCAGTCCTGTTATACTTGCTTGTGAAAACGGAGATCCCTAATTGGATGGCAAATTTGAGTTACATCAAAAAC
TTCAGGTTTAGCAGCTTGGCAAAGGATGAACTGGGATACTGCCTGACCTCATTCGAAGCTGCCATTGAATATATTCGGCAAGGAAGCCTC
TCTGCTAAACCCCCTGAGTCTGAGGGATTTGGAGACAGGCTGTTCCTTAAGCAGAGAATGAGCTTACTCTCTCAGATGACTTCGTCTCCC
ACCGACTGCCTGTTTAAGCACATTGCATCAGGTAACCAGAAAGAAGTGGAGAGACTTCTGAGCCAAGAGGACCATGATAAAGATACCGTC
CAAAAGATGTGTCACCCTCTCTGCTTCTGCGATGACTGTGAGAAACTCGTCTCTGGGAGGTTGAATGATCCCTCAGTTGTCACTCCATTC
TCCAGAGACGACAGGGGGCACACCCCTCTCCATGTGGCTGCTGTCTGTGTGGTGAGAACTCAGCCGTGCTACACTACGGACACGCCGGAG
CTCCCAACGACCGAACGATCCAGAATGGGGATATGTGCCTGTTCGACATGGGCGGTGAGTATTACTGCTTCGCTTCCGACATCACCTGCT
CCTTTCCCGCCAACGGCAAGTTCACTGCAGACCAGAAGGCCGTCTATGAGGCAGTGCTGCGGAGCTCCCGTGCCGTCATGGGTGCCATGA
AGCCAGGTGTCTGGTGGCCTGACATGCACCGCCTGGCTGACCGCATCCACCTGGAGGAGCTGGCCCACATGGGCATCCTGAGCGGCAGCG
TGGACGCCATGGTCCAGGCTCACCTGGGGGCCGTGTTTATGCCTCACGGGCTTGGCCACTTCCTGGGCATTGACGTGCACGACGTGGGAG
GCTACCCAGAGGGCGTGGAGCGCATCGACGAGCCCGGCCTGCGGAGCCTGCGCACTGCACGGCACCTGCAGCCAGGCATGGTGCTCACCG
TGGAGCCGGGCATCTACTTCATCGACCACCTCCTGGATGAGGCCCTGGCGGACCCGGCCCGCGCCTCCTTCCTTAACCGCGAGGTCCTGC
AGCGCTTTCGCGGTTTTGGCGGGGTCCGCATCGAGGAGGACGTCGTGGTGACTGACAGCGGCATAGAGCTGCTGACCTGCGTGCCCCGCA
CTGTGGAAGAGATTGAAGCATGCATGGCAGGCTGTGACAAGGCCTTTACCCCCTTCTCTGGCCCCAAGTAGAGCCAGCCAGAAATCCCAG
CGCACCTGGGGGCCTGGCCTTGCAACCTCTTTTCGTGATGGGCAGCCTGCTGGTCAGCACTCCAGTAGCGAGAGACGGCACCCAGAATCA
GATCCCAGCTTCGGCATTTGATCAGACCAAACAGTGCTGTTTCCCGGGGAGGAAACACTTTTTTAATTACCCTTTTGCAGGCTCCCACCT
TTAATCTGTTTTATACCTTGCTTATTAAATGAGCGACTTAAAATGATTGAAAATAATGCTGTTCTTTAGTAGCAACTAAAATGTGTCTTG

>4650_4650_2_ANKRD27-PEPD_ANKRD27_chr19_33118988_ENST00000306065_PEPD_chr19_33902655_ENST00000397032_length(amino acids)=546AA_BP=473
MALYDEDLLKNPFYLALQKCRPDLCSKVAQIHGIVLVPCKGSLSSSIQSTCQFESYILIPVEEHFQTLNGKDVFIQGNRIKLGAGFACLL
SVPILFEETFYNEKEESFSILCIAHPLEKRESSEEPLAPSDPFSLKTIEDVREFLGRHSERFDRNIASFHRTFRECERKSLRHHIDSANA
LYTKCLQQLLRDSHLKMLAKQEAQMNLMKQAVEIYVHHEIYNLIFKYVGTMEASEDAAFNKITRSLQDLQQKDIGVKPEFSFNIPRAKRE
LAQLNKCTSPQQKLVCLRKVVQLITQSPSQRVNLETMCADDLLSVLLYLLVKTEIPNWMANLSYIKNFRFSSLAKDELGYCLTSFEAAIE
YIRQGSLSAKPPESEGFGDRLFLKQRMSLLSQMTSSPTDCLFKHIASGNQKEVERLLSQEDHDKDTVQKMCHPLCFCDDCEKLVSGRLND
PSVVTPFSRDDRGHTPLHVAAVCVVRTQPCYTTDTPELPTTERSRMGICACSTWAVSITASLPTSPAPFPPTASSLQTRRPSMRQCCGAP

--------------------------------------------------------------
>4650_4650_3_ANKRD27-PEPD_ANKRD27_chr19_33118988_ENST00000306065_PEPD_chr19_33902655_ENST00000436370_length(transcript)=2641nt_BP=1579nt
GGAGTAAGGGGTGGGCTATAGGGCCAGATCGCCGCGCGAGGGTGGTGGGCATCGAGGTCCCAGCAGCGGACGAGGGAGGTGCCGCCGTCG
CCCAGGATGGGCTGGGAATGAAGCGATGTAGCCTTTTAAGAGATTTGCTCTGACCCATCTGAAGTCCATATGGCTCTGTATGATGAAGAC
CTCCTGAAAAATCCTTTCTATCTGGCTCTGCAAAAGTGCCGCCCTGACTTGTGCAGCAAAGTGGCCCAAATCCATGGCATTGTCTTAGTA
CCCTGCAAAGGAAGCCTGTCGAGCAGCATCCAGTCTACTTGTCAGTTTGAGTCCTACATTTTGATACCTGTGGAAGAGCATTTTCAGACC
TTAAATGGAAAGGATGTCTTTATTCAAGGGAACAGGATTAAATTAGGAGCTGGTTTTGCCTGTCTTCTCTCAGTGCCCATTCTCTTTGAA
GAAACTTTCTACAATGAAAAAGAAGAGAGTTTCAGCATCCTGTGTATAGCCCATCCTTTGGAAAAGAGAGAGAGTTCAGAAGAGCCTTTG
GCACCCTCAGATCCCTTTTCCCTGAAAACCATTGAAGATGTGAGAGAGTTCTTGGGAAGACACTCCGAGCGATTTGACAGGAACATCGCC
TCTTTCCATCGAACATTCCGAGAATGCGAGAGAAAGAGCCTCCGTCACCACATAGACTCAGCGAATGCTCTCTACACCAAATGCCTCCAG
CAGCTTCTGAGGGACTCTCACCTGAAAATGCTCGCCAAGCAGGAGGCCCAGATGAACCTGATGAAGCAGGCAGTGGAGATATACGTCCAT
CATGAAATTTACAACCTGATCTTTAAATACGTGGGGACCATGGAGGCAAGTGAGGATGCGGCCTTTAACAAAATCACAAGAAGCCTTCAA
GATCTTCAGCAGAAAGATATTGGTGTGAAACCGGAGTTCAGCTTTAACATACCTCGTGCCAAAAGAGAGCTGGCTCAGCTGAACAAATGC
ACCTCCCCACAGCAGAAGCTTGTCTGCTTGCGAAAAGTGGTGCAGCTCATTACACAGTCTCCAAGCCAGAGAGTGAACCTGGAGACCATG
TGTGCTGATGATCTGCTATCAGTCCTGTTATACTTGCTTGTGAAAACGGAGATCCCTAATTGGATGGCAAATTTGAGTTACATCAAAAAC
TTCAGGTTTAGCAGCTTGGCAAAGGATGAACTGGGATACTGCCTGACCTCATTCGAAGCTGCCATTGAATATATTCGGCAAGGAAGCCTC
TCTGCTAAACCCCCTGAGTCTGAGGGATTTGGAGACAGGCTGTTCCTTAAGCAGAGAATGAGCTTACTCTCTCAGATGACTTCGTCTCCC
ACCGACTGCCTGTTTAAGCACATTGCATCAGGTAACCAGAAAGAAGTGGAGAGACTTCTGAGCCAAGAGGACCATGATAAAGATACCGTC
CAAAAGATGTGTCACCCTCTCTGCTTCTGCGATGACTGTGAGAAACTCGTCTCTGGGAGGTTGAATGATCCCTCAGTTGTCACTCCATTC
TCCAGAGACGACAGGGGGCACACCCCTCTCCATGTGGCTGCTGTCTGTGTGGTGAGAACTCAGCCGTGCTACACTACGGACACGCCGGAG
CTCCCAACGACCGAACGATCCAGAATGGGGATATGTGCCTGTTCGACATGGGCGGTGAGTATTACTGCTTCGCTTCCGACATCACCTGCT
CCTTTCCCGCCAACGGCAAGTTCACTGCAGACCAGAAGGCCGTCTATGAGGCAGTGCTGCGGAGCTCCCGTGCCGTCATGGGTGCCATGA
AGCCAGGTGTCTGGTGGCCTGACATGCACCGCCTGGCTGACCGCATCCACCTGGAGGAGCTGGCCCACATGGGCATCCTGAGCGGCAGCG
TGGACGCCATGGTCCAGGCTCACCTGGGGGCCGTGTTTATGCCTCACGGGCTTGGCCACTTCCTGGGCATTGACGTGCACGACGTGGGAG
GCTACCCAGAGGGCGTGGAGCGCATCGACGAGCCCGGCCTGCGGAGCCTGCGCACTGCACGGCACCTGCAGCCAGGCATGGTGCTCACCG
TGGAGCCGGGCATCTACTTCATCGACCACCTCCTGGATGAGGCCCTGGCGGACCCGGCCCGCGCCTCCTTCCTTAACCGCGAGGTCCTGC
AGCGCTTTCGCGGTTTTGGCGGGGTCCGCATCGAGGAGGACGTCGTGGTGACTGACAGCGGCATAGAGCTGCTGACCTGCGTGCCCCGCA
CTGTGGAAGAGATTGAAGCATGCATGGCAGGCTGTGACAAGGCCTTTACCCCCTTCTCTGGCCCCAAGTAGAGCCAGCCAGAAATCCCAG
CGCACCTGGGGGCCTGGCCTTGCAACCTCTTTTCGTGATGGGCAGCCTGCTGGTCAGCACTCCAGTAGCGAGAGACGGCACCCAGAATCA
GATCCCAGCTTCGGCATTTGATCAGACCAAACAGTGCTGTTTCCCGGGGAGGAAACACTTTTTTAATTACCCTTTTGCAGGCTCCCACCT
TTAATCTGTTTTATACCTTGCTTATTAAATGAGCGACTTAAAATGATTGAAAATAATGCTGTTCTTTAGTAGCAACTAAAATGTGTCTTG

>4650_4650_3_ANKRD27-PEPD_ANKRD27_chr19_33118988_ENST00000306065_PEPD_chr19_33902655_ENST00000436370_length(amino acids)=546AA_BP=473
MALYDEDLLKNPFYLALQKCRPDLCSKVAQIHGIVLVPCKGSLSSSIQSTCQFESYILIPVEEHFQTLNGKDVFIQGNRIKLGAGFACLL
SVPILFEETFYNEKEESFSILCIAHPLEKRESSEEPLAPSDPFSLKTIEDVREFLGRHSERFDRNIASFHRTFRECERKSLRHHIDSANA
LYTKCLQQLLRDSHLKMLAKQEAQMNLMKQAVEIYVHHEIYNLIFKYVGTMEASEDAAFNKITRSLQDLQQKDIGVKPEFSFNIPRAKRE
LAQLNKCTSPQQKLVCLRKVVQLITQSPSQRVNLETMCADDLLSVLLYLLVKTEIPNWMANLSYIKNFRFSSLAKDELGYCLTSFEAAIE
YIRQGSLSAKPPESEGFGDRLFLKQRMSLLSQMTSSPTDCLFKHIASGNQKEVERLLSQEDHDKDTVQKMCHPLCFCDDCEKLVSGRLND
PSVVTPFSRDDRGHTPLHVAAVCVVRTQPCYTTDTPELPTTERSRMGICACSTWAVSITASLPTSPAPFPPTASSLQTRRPSMRQCCGAP

--------------------------------------------------------------
>4650_4650_4_ANKRD27-PEPD_ANKRD27_chr19_33118989_ENST00000306065_PEPD_chr19_33902655_ENST00000244137_length(transcript)=2715nt_BP=1579nt
GGAGTAAGGGGTGGGCTATAGGGCCAGATCGCCGCGCGAGGGTGGTGGGCATCGAGGTCCCAGCAGCGGACGAGGGAGGTGCCGCCGTCG
CCCAGGATGGGCTGGGAATGAAGCGATGTAGCCTTTTAAGAGATTTGCTCTGACCCATCTGAAGTCCATATGGCTCTGTATGATGAAGAC
CTCCTGAAAAATCCTTTCTATCTGGCTCTGCAAAAGTGCCGCCCTGACTTGTGCAGCAAAGTGGCCCAAATCCATGGCATTGTCTTAGTA
CCCTGCAAAGGAAGCCTGTCGAGCAGCATCCAGTCTACTTGTCAGTTTGAGTCCTACATTTTGATACCTGTGGAAGAGCATTTTCAGACC
TTAAATGGAAAGGATGTCTTTATTCAAGGGAACAGGATTAAATTAGGAGCTGGTTTTGCCTGTCTTCTCTCAGTGCCCATTCTCTTTGAA
GAAACTTTCTACAATGAAAAAGAAGAGAGTTTCAGCATCCTGTGTATAGCCCATCCTTTGGAAAAGAGAGAGAGTTCAGAAGAGCCTTTG
GCACCCTCAGATCCCTTTTCCCTGAAAACCATTGAAGATGTGAGAGAGTTCTTGGGAAGACACTCCGAGCGATTTGACAGGAACATCGCC
TCTTTCCATCGAACATTCCGAGAATGCGAGAGAAAGAGCCTCCGTCACCACATAGACTCAGCGAATGCTCTCTACACCAAATGCCTCCAG
CAGCTTCTGAGGGACTCTCACCTGAAAATGCTCGCCAAGCAGGAGGCCCAGATGAACCTGATGAAGCAGGCAGTGGAGATATACGTCCAT
CATGAAATTTACAACCTGATCTTTAAATACGTGGGGACCATGGAGGCAAGTGAGGATGCGGCCTTTAACAAAATCACAAGAAGCCTTCAA
GATCTTCAGCAGAAAGATATTGGTGTGAAACCGGAGTTCAGCTTTAACATACCTCGTGCCAAAAGAGAGCTGGCTCAGCTGAACAAATGC
ACCTCCCCACAGCAGAAGCTTGTCTGCTTGCGAAAAGTGGTGCAGCTCATTACACAGTCTCCAAGCCAGAGAGTGAACCTGGAGACCATG
TGTGCTGATGATCTGCTATCAGTCCTGTTATACTTGCTTGTGAAAACGGAGATCCCTAATTGGATGGCAAATTTGAGTTACATCAAAAAC
TTCAGGTTTAGCAGCTTGGCAAAGGATGAACTGGGATACTGCCTGACCTCATTCGAAGCTGCCATTGAATATATTCGGCAAGGAAGCCTC
TCTGCTAAACCCCCTGAGTCTGAGGGATTTGGAGACAGGCTGTTCCTTAAGCAGAGAATGAGCTTACTCTCTCAGATGACTTCGTCTCCC
ACCGACTGCCTGTTTAAGCACATTGCATCAGGTAACCAGAAAGAAGTGGAGAGACTTCTGAGCCAAGAGGACCATGATAAAGATACCGTC
CAAAAGATGTGTCACCCTCTCTGCTTCTGCGATGACTGTGAGAAACTCGTCTCTGGGAGGTTGAATGATCCCTCAGTTGTCACTCCATTC
TCCAGAGACGACAGGGGGCACACCCCTCTCCATGTGGCTGCTGTCTGTGTGGTGAGAACTCAGCCGTGCTACACTACGGACACGCCGGAG
CTCCCAACGACCGAACGATCCAGAATGGGGATATGTGCCTGTTCGACATGGGCGGTGAGTATTACTGCTTCGCTTCCGACATCACCTGCT
CCTTTCCCGCCAACGGCAAGTTCACTGCAGACCAGAAGGCCGTCTATGAGGCAGTGCTGCGGAGCTCCCGTGCCGTCATGGGTGCCATGA
AGCCAGGTGTCTGGTGGCCTGACATGCACCGCCTGGCTGACCGCATCCACCTGGAGGAGCTGGCCCACATGGGCATCCTGAGCGGCAGCG
TGGACGCCATGGTCCAGGCTCACCTGGGGGCCGTGTTTATGCCTCACGGGCTTGGCCACTTCCTGGGCATTGACGTGCACGACGTGGGAG
GCTACCCAGAGGGCGTGGAGCGCATCGACGAGCCCGGCCTGCGGAGCCTGCGCACTGCACGGCACCTGCAGCCAGGCATGGTGCTCACCG
TGGAGCCGGGCATCTACTTCATCGACCACCTCCTGGATGAGGCCCTGGCGGACCCGGCCCGCGCCTCCTTCCTTAACCGCGAGGTCCTGC
AGCGCTTTCGCGGTTTTGGCGGGGTCCGCATCGAGGAGGACGTCGTGGTGACTGACAGCGGCATAGAGCTGCTGACCTGCGTGCCCCGCA
CTGTGGAAGAGATTGAAGCATGCATGGCAGGCTGTGACAAGGCCTTTACCCCCTTCTCTGGCCCCAAGTAGAGCCAGCCAGAAATCCCAG
CGCACCTGGGGGCCTGGCCTTGCAACCTCTTTTCGTGATGGGCAGCCTGCTGGTCAGCACTCCAGTAGCGAGAGACGGCACCCAGAATCA
GATCCCAGCTTCGGCATTTGATCAGACCAAACAGTGCTGTTTCCCGGGGAGGAAACACTTTTTTAATTACCCTTTTGCAGGCTCCCACCT
TTAATCTGTTTTATACCTTGCTTATTAAATGAGCGACTTAAAATGATTGAAAATAATGCTGTTCTTTAGTAGCAACTAAAATGTGTCTTG
CTGTCATTTATATTCCTTTTCCCAGGAAAGAAGCATTTCTGATACTTTCTGTCAAAAATCAATATGCAGAATGGCATTTGCAATAAAAGG

>4650_4650_4_ANKRD27-PEPD_ANKRD27_chr19_33118989_ENST00000306065_PEPD_chr19_33902655_ENST00000244137_length(amino acids)=546AA_BP=473
MALYDEDLLKNPFYLALQKCRPDLCSKVAQIHGIVLVPCKGSLSSSIQSTCQFESYILIPVEEHFQTLNGKDVFIQGNRIKLGAGFACLL
SVPILFEETFYNEKEESFSILCIAHPLEKRESSEEPLAPSDPFSLKTIEDVREFLGRHSERFDRNIASFHRTFRECERKSLRHHIDSANA
LYTKCLQQLLRDSHLKMLAKQEAQMNLMKQAVEIYVHHEIYNLIFKYVGTMEASEDAAFNKITRSLQDLQQKDIGVKPEFSFNIPRAKRE
LAQLNKCTSPQQKLVCLRKVVQLITQSPSQRVNLETMCADDLLSVLLYLLVKTEIPNWMANLSYIKNFRFSSLAKDELGYCLTSFEAAIE
YIRQGSLSAKPPESEGFGDRLFLKQRMSLLSQMTSSPTDCLFKHIASGNQKEVERLLSQEDHDKDTVQKMCHPLCFCDDCEKLVSGRLND
PSVVTPFSRDDRGHTPLHVAAVCVVRTQPCYTTDTPELPTTERSRMGICACSTWAVSITASLPTSPAPFPPTASSLQTRRPSMRQCCGAP

--------------------------------------------------------------
>4650_4650_5_ANKRD27-PEPD_ANKRD27_chr19_33118989_ENST00000306065_PEPD_chr19_33902655_ENST00000397032_length(transcript)=2685nt_BP=1579nt
GGAGTAAGGGGTGGGCTATAGGGCCAGATCGCCGCGCGAGGGTGGTGGGCATCGAGGTCCCAGCAGCGGACGAGGGAGGTGCCGCCGTCG
CCCAGGATGGGCTGGGAATGAAGCGATGTAGCCTTTTAAGAGATTTGCTCTGACCCATCTGAAGTCCATATGGCTCTGTATGATGAAGAC
CTCCTGAAAAATCCTTTCTATCTGGCTCTGCAAAAGTGCCGCCCTGACTTGTGCAGCAAAGTGGCCCAAATCCATGGCATTGTCTTAGTA
CCCTGCAAAGGAAGCCTGTCGAGCAGCATCCAGTCTACTTGTCAGTTTGAGTCCTACATTTTGATACCTGTGGAAGAGCATTTTCAGACC
TTAAATGGAAAGGATGTCTTTATTCAAGGGAACAGGATTAAATTAGGAGCTGGTTTTGCCTGTCTTCTCTCAGTGCCCATTCTCTTTGAA
GAAACTTTCTACAATGAAAAAGAAGAGAGTTTCAGCATCCTGTGTATAGCCCATCCTTTGGAAAAGAGAGAGAGTTCAGAAGAGCCTTTG
GCACCCTCAGATCCCTTTTCCCTGAAAACCATTGAAGATGTGAGAGAGTTCTTGGGAAGACACTCCGAGCGATTTGACAGGAACATCGCC
TCTTTCCATCGAACATTCCGAGAATGCGAGAGAAAGAGCCTCCGTCACCACATAGACTCAGCGAATGCTCTCTACACCAAATGCCTCCAG
CAGCTTCTGAGGGACTCTCACCTGAAAATGCTCGCCAAGCAGGAGGCCCAGATGAACCTGATGAAGCAGGCAGTGGAGATATACGTCCAT
CATGAAATTTACAACCTGATCTTTAAATACGTGGGGACCATGGAGGCAAGTGAGGATGCGGCCTTTAACAAAATCACAAGAAGCCTTCAA
GATCTTCAGCAGAAAGATATTGGTGTGAAACCGGAGTTCAGCTTTAACATACCTCGTGCCAAAAGAGAGCTGGCTCAGCTGAACAAATGC
ACCTCCCCACAGCAGAAGCTTGTCTGCTTGCGAAAAGTGGTGCAGCTCATTACACAGTCTCCAAGCCAGAGAGTGAACCTGGAGACCATG
TGTGCTGATGATCTGCTATCAGTCCTGTTATACTTGCTTGTGAAAACGGAGATCCCTAATTGGATGGCAAATTTGAGTTACATCAAAAAC
TTCAGGTTTAGCAGCTTGGCAAAGGATGAACTGGGATACTGCCTGACCTCATTCGAAGCTGCCATTGAATATATTCGGCAAGGAAGCCTC
TCTGCTAAACCCCCTGAGTCTGAGGGATTTGGAGACAGGCTGTTCCTTAAGCAGAGAATGAGCTTACTCTCTCAGATGACTTCGTCTCCC
ACCGACTGCCTGTTTAAGCACATTGCATCAGGTAACCAGAAAGAAGTGGAGAGACTTCTGAGCCAAGAGGACCATGATAAAGATACCGTC
CAAAAGATGTGTCACCCTCTCTGCTTCTGCGATGACTGTGAGAAACTCGTCTCTGGGAGGTTGAATGATCCCTCAGTTGTCACTCCATTC
TCCAGAGACGACAGGGGGCACACCCCTCTCCATGTGGCTGCTGTCTGTGTGGTGAGAACTCAGCCGTGCTACACTACGGACACGCCGGAG
CTCCCAACGACCGAACGATCCAGAATGGGGATATGTGCCTGTTCGACATGGGCGGTGAGTATTACTGCTTCGCTTCCGACATCACCTGCT
CCTTTCCCGCCAACGGCAAGTTCACTGCAGACCAGAAGGCCGTCTATGAGGCAGTGCTGCGGAGCTCCCGTGCCGTCATGGGTGCCATGA
AGCCAGGTGTCTGGTGGCCTGACATGCACCGCCTGGCTGACCGCATCCACCTGGAGGAGCTGGCCCACATGGGCATCCTGAGCGGCAGCG
TGGACGCCATGGTCCAGGCTCACCTGGGGGCCGTGTTTATGCCTCACGGGCTTGGCCACTTCCTGGGCATTGACGTGCACGACGTGGGAG
GCTACCCAGAGGGCGTGGAGCGCATCGACGAGCCCGGCCTGCGGAGCCTGCGCACTGCACGGCACCTGCAGCCAGGCATGGTGCTCACCG
TGGAGCCGGGCATCTACTTCATCGACCACCTCCTGGATGAGGCCCTGGCGGACCCGGCCCGCGCCTCCTTCCTTAACCGCGAGGTCCTGC
AGCGCTTTCGCGGTTTTGGCGGGGTCCGCATCGAGGAGGACGTCGTGGTGACTGACAGCGGCATAGAGCTGCTGACCTGCGTGCCCCGCA
CTGTGGAAGAGATTGAAGCATGCATGGCAGGCTGTGACAAGGCCTTTACCCCCTTCTCTGGCCCCAAGTAGAGCCAGCCAGAAATCCCAG
CGCACCTGGGGGCCTGGCCTTGCAACCTCTTTTCGTGATGGGCAGCCTGCTGGTCAGCACTCCAGTAGCGAGAGACGGCACCCAGAATCA
GATCCCAGCTTCGGCATTTGATCAGACCAAACAGTGCTGTTTCCCGGGGAGGAAACACTTTTTTAATTACCCTTTTGCAGGCTCCCACCT
TTAATCTGTTTTATACCTTGCTTATTAAATGAGCGACTTAAAATGATTGAAAATAATGCTGTTCTTTAGTAGCAACTAAAATGTGTCTTG

>4650_4650_5_ANKRD27-PEPD_ANKRD27_chr19_33118989_ENST00000306065_PEPD_chr19_33902655_ENST00000397032_length(amino acids)=546AA_BP=473
MALYDEDLLKNPFYLALQKCRPDLCSKVAQIHGIVLVPCKGSLSSSIQSTCQFESYILIPVEEHFQTLNGKDVFIQGNRIKLGAGFACLL
SVPILFEETFYNEKEESFSILCIAHPLEKRESSEEPLAPSDPFSLKTIEDVREFLGRHSERFDRNIASFHRTFRECERKSLRHHIDSANA
LYTKCLQQLLRDSHLKMLAKQEAQMNLMKQAVEIYVHHEIYNLIFKYVGTMEASEDAAFNKITRSLQDLQQKDIGVKPEFSFNIPRAKRE
LAQLNKCTSPQQKLVCLRKVVQLITQSPSQRVNLETMCADDLLSVLLYLLVKTEIPNWMANLSYIKNFRFSSLAKDELGYCLTSFEAAIE
YIRQGSLSAKPPESEGFGDRLFLKQRMSLLSQMTSSPTDCLFKHIASGNQKEVERLLSQEDHDKDTVQKMCHPLCFCDDCEKLVSGRLND
PSVVTPFSRDDRGHTPLHVAAVCVVRTQPCYTTDTPELPTTERSRMGICACSTWAVSITASLPTSPAPFPPTASSLQTRRPSMRQCCGAP

--------------------------------------------------------------
>4650_4650_6_ANKRD27-PEPD_ANKRD27_chr19_33118989_ENST00000306065_PEPD_chr19_33902655_ENST00000436370_length(transcript)=2641nt_BP=1579nt
GGAGTAAGGGGTGGGCTATAGGGCCAGATCGCCGCGCGAGGGTGGTGGGCATCGAGGTCCCAGCAGCGGACGAGGGAGGTGCCGCCGTCG
CCCAGGATGGGCTGGGAATGAAGCGATGTAGCCTTTTAAGAGATTTGCTCTGACCCATCTGAAGTCCATATGGCTCTGTATGATGAAGAC
CTCCTGAAAAATCCTTTCTATCTGGCTCTGCAAAAGTGCCGCCCTGACTTGTGCAGCAAAGTGGCCCAAATCCATGGCATTGTCTTAGTA
CCCTGCAAAGGAAGCCTGTCGAGCAGCATCCAGTCTACTTGTCAGTTTGAGTCCTACATTTTGATACCTGTGGAAGAGCATTTTCAGACC
TTAAATGGAAAGGATGTCTTTATTCAAGGGAACAGGATTAAATTAGGAGCTGGTTTTGCCTGTCTTCTCTCAGTGCCCATTCTCTTTGAA
GAAACTTTCTACAATGAAAAAGAAGAGAGTTTCAGCATCCTGTGTATAGCCCATCCTTTGGAAAAGAGAGAGAGTTCAGAAGAGCCTTTG
GCACCCTCAGATCCCTTTTCCCTGAAAACCATTGAAGATGTGAGAGAGTTCTTGGGAAGACACTCCGAGCGATTTGACAGGAACATCGCC
TCTTTCCATCGAACATTCCGAGAATGCGAGAGAAAGAGCCTCCGTCACCACATAGACTCAGCGAATGCTCTCTACACCAAATGCCTCCAG
CAGCTTCTGAGGGACTCTCACCTGAAAATGCTCGCCAAGCAGGAGGCCCAGATGAACCTGATGAAGCAGGCAGTGGAGATATACGTCCAT
CATGAAATTTACAACCTGATCTTTAAATACGTGGGGACCATGGAGGCAAGTGAGGATGCGGCCTTTAACAAAATCACAAGAAGCCTTCAA
GATCTTCAGCAGAAAGATATTGGTGTGAAACCGGAGTTCAGCTTTAACATACCTCGTGCCAAAAGAGAGCTGGCTCAGCTGAACAAATGC
ACCTCCCCACAGCAGAAGCTTGTCTGCTTGCGAAAAGTGGTGCAGCTCATTACACAGTCTCCAAGCCAGAGAGTGAACCTGGAGACCATG
TGTGCTGATGATCTGCTATCAGTCCTGTTATACTTGCTTGTGAAAACGGAGATCCCTAATTGGATGGCAAATTTGAGTTACATCAAAAAC
TTCAGGTTTAGCAGCTTGGCAAAGGATGAACTGGGATACTGCCTGACCTCATTCGAAGCTGCCATTGAATATATTCGGCAAGGAAGCCTC
TCTGCTAAACCCCCTGAGTCTGAGGGATTTGGAGACAGGCTGTTCCTTAAGCAGAGAATGAGCTTACTCTCTCAGATGACTTCGTCTCCC
ACCGACTGCCTGTTTAAGCACATTGCATCAGGTAACCAGAAAGAAGTGGAGAGACTTCTGAGCCAAGAGGACCATGATAAAGATACCGTC
CAAAAGATGTGTCACCCTCTCTGCTTCTGCGATGACTGTGAGAAACTCGTCTCTGGGAGGTTGAATGATCCCTCAGTTGTCACTCCATTC
TCCAGAGACGACAGGGGGCACACCCCTCTCCATGTGGCTGCTGTCTGTGTGGTGAGAACTCAGCCGTGCTACACTACGGACACGCCGGAG
CTCCCAACGACCGAACGATCCAGAATGGGGATATGTGCCTGTTCGACATGGGCGGTGAGTATTACTGCTTCGCTTCCGACATCACCTGCT
CCTTTCCCGCCAACGGCAAGTTCACTGCAGACCAGAAGGCCGTCTATGAGGCAGTGCTGCGGAGCTCCCGTGCCGTCATGGGTGCCATGA
AGCCAGGTGTCTGGTGGCCTGACATGCACCGCCTGGCTGACCGCATCCACCTGGAGGAGCTGGCCCACATGGGCATCCTGAGCGGCAGCG
TGGACGCCATGGTCCAGGCTCACCTGGGGGCCGTGTTTATGCCTCACGGGCTTGGCCACTTCCTGGGCATTGACGTGCACGACGTGGGAG
GCTACCCAGAGGGCGTGGAGCGCATCGACGAGCCCGGCCTGCGGAGCCTGCGCACTGCACGGCACCTGCAGCCAGGCATGGTGCTCACCG
TGGAGCCGGGCATCTACTTCATCGACCACCTCCTGGATGAGGCCCTGGCGGACCCGGCCCGCGCCTCCTTCCTTAACCGCGAGGTCCTGC
AGCGCTTTCGCGGTTTTGGCGGGGTCCGCATCGAGGAGGACGTCGTGGTGACTGACAGCGGCATAGAGCTGCTGACCTGCGTGCCCCGCA
CTGTGGAAGAGATTGAAGCATGCATGGCAGGCTGTGACAAGGCCTTTACCCCCTTCTCTGGCCCCAAGTAGAGCCAGCCAGAAATCCCAG
CGCACCTGGGGGCCTGGCCTTGCAACCTCTTTTCGTGATGGGCAGCCTGCTGGTCAGCACTCCAGTAGCGAGAGACGGCACCCAGAATCA
GATCCCAGCTTCGGCATTTGATCAGACCAAACAGTGCTGTTTCCCGGGGAGGAAACACTTTTTTAATTACCCTTTTGCAGGCTCCCACCT
TTAATCTGTTTTATACCTTGCTTATTAAATGAGCGACTTAAAATGATTGAAAATAATGCTGTTCTTTAGTAGCAACTAAAATGTGTCTTG

>4650_4650_6_ANKRD27-PEPD_ANKRD27_chr19_33118989_ENST00000306065_PEPD_chr19_33902655_ENST00000436370_length(amino acids)=546AA_BP=473
MALYDEDLLKNPFYLALQKCRPDLCSKVAQIHGIVLVPCKGSLSSSIQSTCQFESYILIPVEEHFQTLNGKDVFIQGNRIKLGAGFACLL
SVPILFEETFYNEKEESFSILCIAHPLEKRESSEEPLAPSDPFSLKTIEDVREFLGRHSERFDRNIASFHRTFRECERKSLRHHIDSANA
LYTKCLQQLLRDSHLKMLAKQEAQMNLMKQAVEIYVHHEIYNLIFKYVGTMEASEDAAFNKITRSLQDLQQKDIGVKPEFSFNIPRAKRE
LAQLNKCTSPQQKLVCLRKVVQLITQSPSQRVNLETMCADDLLSVLLYLLVKTEIPNWMANLSYIKNFRFSSLAKDELGYCLTSFEAAIE
YIRQGSLSAKPPESEGFGDRLFLKQRMSLLSQMTSSPTDCLFKHIASGNQKEVERLLSQEDHDKDTVQKMCHPLCFCDDCEKLVSGRLND
PSVVTPFSRDDRGHTPLHVAAVCVVRTQPCYTTDTPELPTTERSRMGICACSTWAVSITASLPTSPAPFPPTASSLQTRRPSMRQCCGAP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ANKRD27-PEPD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneANKRD27chr19:33118988chr19:33902655ENST00000306065-1529451_730473.33333333333331051.0RAB32
HgeneANKRD27chr19:33118989chr19:33902655ENST00000306065-1529451_730473.33333333333331051.0RAB32
HgeneANKRD27chr19:33118988chr19:33902655ENST00000306065-1529451_600473.33333333333331051.0RAB38
HgeneANKRD27chr19:33118989chr19:33902655ENST00000306065-1529451_600473.33333333333331051.0RAB38


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANKRD27-PEPD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANKRD27-PEPD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0268532Deficiency of prolidase9CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneC0019209Hepatomegaly1CTD_human
TgeneC0035242Respiratory Tract Diseases1CTD_human
TgeneC0037299Skin Ulcer1CTD_human
TgeneC0038002Splenomegaly1CTD_human
TgeneC0353676Organophosphorus Poisoning1CTD_human
TgeneC0700359Organophosphate poisoning1CTD_human
TgeneC3494247Organothiophosphonate Poisoning1CTD_human
TgeneC3494248Organothiophosphate Poisoning1CTD_human
TgeneC3714514Infection1CTD_human