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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANKRD27-ZFP14 (FusionGDB2 ID:HG84079TG57677)

Fusion Gene Summary for ANKRD27-ZFP14

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD27-ZFP14
Fusion gene ID: hg84079tg57677
HgeneTgene
Gene symbol

ANKRD27

ZFP14

Gene ID

84079

57677

Gene nameankyrin repeat domain 27ZFP14 zinc finger protein
SynonymsPP12899|VARPZNF531
Cytomap('ANKRD27')('ZFP14')

19q13.11

19q13.12

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat domain-containing protein 27VPS9 domain-containing proteinVPS9-ankyrin-repeat proteinVps9 domain and ankyrin-repeat-containing proteinankyrin repeat domain 27 (VPS9 domain)zinc finger protein 14 homologzinc finger protein 531
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000306065, ENST00000587352, 
Fusion gene scores* DoF score14 X 14 X 8=15681 X 1 X 1=1
# samples 161
** MAII scorelog2(16/1568*10)=-3.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: ANKRD27 [Title/Abstract] AND ZFP14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANKRD27(33134029)-ZFP14(36832492), # samples:2
Anticipated loss of major functional domain due to fusion event.ANKRD27-ZFP14 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD27-ZFP14 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD27-ZFP14 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD27-ZFP14 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANKRD27

GO:0035544

negative regulation of SNARE complex assembly

24856514

HgeneANKRD27

GO:0045022

early endosome to late endosome transport

16525121


check buttonFusion gene breakpoints across ANKRD27 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ZFP14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-66-2742-01AANKRD27chr19

33134029

-ZFP14chr19

36832492

-


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Fusion Gene ORF analysis for ANKRD27-ZFP14

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000306065ENST00000589280ANKRD27chr19

33134029

-ZFP14chr19

36832492

-
5CDS-intronENST00000587352ENST00000589280ANKRD27chr19

33134029

-ZFP14chr19

36832492

-
In-frameENST00000306065ENST00000270001ANKRD27chr19

33134029

-ZFP14chr19

36832492

-
In-frameENST00000587352ENST00000270001ANKRD27chr19

33134029

-ZFP14chr19

36832492

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000306065ANKRD27chr1933134029-ENST00000270001ZFP14chr1936832492-62729419432307454
ENST00000587352ANKRD27chr1933134029-ENST00000270001ZFP14chr1936832492-62429119132277454

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000306065ENST00000270001ANKRD27chr1933134029-ZFP14chr1936832492-0.0002821940.9997178
ENST00000587352ENST00000270001ANKRD27chr1933134029-ZFP14chr1936832492-0.0002820440.9997179

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Fusion Genomic Features for ANKRD27-ZFP14


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ANKRD27-ZFP14


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:33134029/chr19:36832492)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZFP14chr19:33134029chr19:36832492ENST0000027000135172_19478534.0Zinc fingerC2H2-type 1
TgeneZFP14chr19:33134029chr19:36832492ENST0000027000135200_22278534.0Zinc fingerC2H2-type 2
TgeneZFP14chr19:33134029chr19:36832492ENST0000027000135228_25078534.0Zinc fingerC2H2-type 3
TgeneZFP14chr19:33134029chr19:36832492ENST0000027000135256_27878534.0Zinc fingerC2H2-type 4
TgeneZFP14chr19:33134029chr19:36832492ENST0000027000135284_30678534.0Zinc fingerC2H2-type 5
TgeneZFP14chr19:33134029chr19:36832492ENST0000027000135312_33478534.0Zinc fingerC2H2-type 6
TgeneZFP14chr19:33134029chr19:36832492ENST0000027000135340_36278534.0Zinc fingerC2H2-type 7
TgeneZFP14chr19:33134029chr19:36832492ENST0000027000135368_39078534.0Zinc fingerC2H2-type 8
TgeneZFP14chr19:33134029chr19:36832492ENST0000027000135396_41878534.0Zinc fingerC2H2-type 9
TgeneZFP14chr19:33134029chr19:36832492ENST0000027000135424_44678534.0Zinc fingerC2H2-type 10
TgeneZFP14chr19:33134029chr19:36832492ENST0000027000135452_47478534.0Zinc fingerC2H2-type 11
TgeneZFP14chr19:33134029chr19:36832492ENST0000027000135480_50278534.0Zinc fingerC2H2-type 12
TgeneZFP14chr19:33134029chr19:36832492ENST0000027000135508_53078534.0Zinc fingerC2H2-type 13

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD27chr19:33134029chr19:36832492ENST00000306065-929233_3712601051.0DomainVPS9
HgeneANKRD27chr19:33134029chr19:36832492ENST00000306065-9291_3722601051.0RegionSufficient for GEF activity towards RAB21
HgeneANKRD27chr19:33134029chr19:36832492ENST00000306065-929396_4262601051.0RepeatNote=ANK 1
HgeneANKRD27chr19:33134029chr19:36832492ENST00000306065-929462_4912601051.0RepeatNote=ANK 2
HgeneANKRD27chr19:33134029chr19:36832492ENST00000306065-929495_5242601051.0RepeatNote=ANK 3
HgeneANKRD27chr19:33134029chr19:36832492ENST00000306065-929528_5602601051.0RepeatNote=ANK 4
HgeneANKRD27chr19:33134029chr19:36832492ENST00000306065-929564_5932601051.0RepeatNote=ANK 5
HgeneANKRD27chr19:33134029chr19:36832492ENST00000306065-929597_6272601051.0RepeatNote=ANK 6
HgeneANKRD27chr19:33134029chr19:36832492ENST00000306065-929668_6982601051.0RepeatNote=ANK 7
HgeneANKRD27chr19:33134029chr19:36832492ENST00000306065-929743_7722601051.0RepeatNote=ANK 8
HgeneANKRD27chr19:33134029chr19:36832492ENST00000306065-929776_8052601051.0RepeatNote=ANK 9
HgeneANKRD27chr19:33134029chr19:36832492ENST00000306065-929809_8382601051.0RepeatNote=ANK 10
HgeneANKRD27chr19:33134029chr19:36832492ENST00000306065-929842_8712601051.0RepeatNote=ANK 11
TgeneZFP14chr19:33134029chr19:36832492ENST00000270001356_7878534.0DomainKRAB


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Fusion Gene Sequence for ANKRD27-ZFP14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4656_4656_1_ANKRD27-ZFP14_ANKRD27_chr19_33134029_ENST00000306065_ZFP14_chr19_36832492_ENST00000270001_length(transcript)=6272nt_BP=941nt
GGAGTAAGGGGTGGGCTATAGGGCCAGATCGCCGCGCGAGGGTGGTGGGCATCGAGGTCCCAGCAGCGGACGAGGGAGGTGCCGCCGTCG
CCCAGGATGGGCTGGGAATGAAGCGATGTAGCCTTTTAAGAGATTTGCTCTGACCCATCTGAAGTCCATATGGCTCTGTATGATGAAGAC
CTCCTGAAAAATCCTTTCTATCTGGCTCTGCAAAAGTGCCGCCCTGACTTGTGCAGCAAAGTGGCCCAAATCCATGGCATTGTCTTAGTA
CCCTGCAAAGGAAGCCTGTCGAGCAGCATCCAGTCTACTTGTCAGTTTGAGTCCTACATTTTGATACCTGTGGAAGAGCATTTTCAGACC
TTAAATGGAAAGGATGTCTTTATTCAAGGGAACAGGATTAAATTAGGAGCTGGTTTTGCCTGTCTTCTCTCAGTGCCCATTCTCTTTGAA
GAAACTTTCTACAATGAAAAAGAAGAGAGTTTCAGCATCCTGTGTATAGCCCATCCTTTGGAAAAGAGAGAGAGTTCAGAAGAGCCTTTG
GCACCCTCAGATCCCTTTTCCCTGAAAACCATTGAAGATGTGAGAGAGTTCTTGGGAAGACACTCCGAGCGATTTGACAGGAACATCGCC
TCTTTCCATCGAACATTCCGAGAATGCGAGAGAAAGAGCCTCCGTCACCACATAGACTCAGCGAATGCTCTCTACACCAAATGCCTCCAG
CAGCTTCTGAGGGACTCTCACCTGAAAATGCTCGCCAAGCAGGAGGCCCAGATGAACCTGATGAAGCAGGCAGTGGAGATATACGTCCAT
CATGAAATTTACAACCTGATCTTTAAATACGTGGGGACCATGGAGGCAAGTGAGGATGCGGCCTTTAACAAAATCACAAGAAGCCTTCAA
GATCTTCAGCAGAAAGATATTGGTGTGAAACCGGAGTTCAGATTTGGAGTCCAGATACAGGACCAATACTTTATCTCCAGAAAAGGACAT
TTATGAAATATATTCATTTCAGTGGGATATAATGGAAAGAATTAAAAGCTATAGCCTTCAGGGTTCCATTTTTAGGAATGATTGGGAATG
CAAAAGCAAGATTGAGGGGGAAAAGGAACAACAAGAGGGATATTTTGGGCAAGTGAAAATTACCTCTGAAAAAATGACCACTTACAAAAG
GCACAATTTTCTTACTGAGTATCAGATCGTTCATAATGGAGAAAAGGTGTATGAGTGTAAGGAGTGTAGGAAGACCTTTATTCGTCGCTC
AACACTTAGTCAACACCTGAGAATTCATACTGGTGAGAAACCTTATAAGTGTAAGGAATGTGGGCAGGCCTTTAGACAGCGTGCACATCT
TATTCGACATCACAAACTTCACACCGGTGAGAAACCCTATGAATGTAAGGAGTGTGGGAAGGCCTTTACAGTGCTCCAAGAACTTACTCA
ACATCAGAGACTTCATACGGGTGAAAAACCCTATGAATGTAAGGAATGTGGAAAGGCCTTTAGAGTACATCAGCAACTGGCTCGACATCA
GAGAATTCACACTGGTGAGAAACCCTATGAATGTAAGGACTGTGGAAAGACCTTTAGACAGTGTACACACCTTACACGCCATCAGAGACT
TCATACTGCTGAAAAGCTCTATGAATGTAAGGAATGTGGGAAAGCCTTCGTATGTGGTCCAGACCTTAGAGTACATCAGAAAATTCATTT
TGGTGAGAAACCCTATGAATGTAAGGAGTGTGGAAAGGCTTTTAGAATATGCCAACAACTTACTGTTCATCAGAGTATTCATACTGGTGA
GAAACCCTACGAATGTAAGGAATGTGGGAAGACTTTTAGATTAAGACAACAACTAGTTCGCCATCAGAGAATACATACTCGTGAGAAACC
CTATGAATGTATGGAATGTTGGAAGACCTTTAGTAGTTACTCACAGCTTATTTCACACCAGAGCATTCATATTGGTGAGAGACCCTATGA
ATGTGAAGAGTGTGGAAAGGCCTTTAGACTGCTCTCACAACTTACTCAGCATCAAAGTATTCACACTGGTGAGAAACCTTATGAATGTAA
GGAATGTAGAAAACCTTTTAGACTGCTCTCACAACTTACCCAACATCAGAGTATTCACACTGGTGAGAAACCTTATGAATGTAAGGAATG
TGGTAAGGCTTTTAGACTTTATTCATTTCTTACTCAACACCAGAGAATTCATACTGGTGAGAAGCCCTACAAGTGTAAGGAGTGTAAGAA
GGCCTTTAGACAGCATTCACACCTTACTCAGCATCAGAAGATTCATAATGGAATTTAATAGAAGAAAGCCTTCAAATGTATATGATGTTA
CAGAACATCAGAAAATTCATTTTTGAGAAAATGTGTTTCATGCTCAATTCCAAGCATAATAAATTTTATATTAGAGAAAGAATATGTTGA
TTTAAAAGCCTTCCAACACCATTTAAACATGGTTTATCTTCAGCAAATTCCTATGAGAGAATAATGTAATGAATGTAGGAAAATCTTTAG
CCTTATCTGTCATTATCTCCCTTTCTCCACTTGATTACCAGTTTGATTTATTGGACAAGATACTAAGCTTCTGTGCCTCATTTTGCTGAC
TTGTAAAATGGTAATAATAGTACTTATATGTATTAGTTATTTATTGCTGCGTAATAAATTACCACAGACTTAGTAGCATAAAATAACATA
TAATTATATCTTATAATTTGGATCAGGAGTATAGGCATGACTTAGTTGGGTCCTCTGCTTCAGGGTCTCTTGCAAGGCTACAGATTTCAG
CCAGGGCTGAGGTCTCATCTGAAGGCTCAACTGGGGAAGGATCCACATCCAGACTAACATAGTTGTTACCCAATGTATTTCCGTGAGGCC
TGTTGCATTGAGATTCTCAGTTTCTAGCTGGCTGTTGGCTGAACGCTGACTGCAGCTCCTGGCCACAATAGCCTCATCAACATGGCTGCT
TGCTTCATCAAGGCATGCAAGCCAAAAGGGAGGACAGTCTGCTAGCAAGATGGAAGTTACCATCTTGTGTAATCTAATCATGGAAGTAAC
ATTCCCTCACCTTCTACTGGTAGAAGTAAGTTACTAGGATAGTCCACACTCAAGAGAACGGGATGATACAAGAGTGTGAATAAGTCCTGG
AGACAGGACCACTGGGGGGCCTGTTTAGAGTCAGCCTGCCACACTGTGGAATAGGATTGTTGCAAGGAGTAAGTAGTTAATACTTGGAGG
AATCACAGTCATATAGCATGTATTCTGTAAATATTATCTGTAATTGTTATTATTGTCATTAGTATTAGTGAATTCACGTAAAAGGAAGAT
CTGTAGACATAATAAATGTAGAAATGCCTCCTGTCACCTCTCAGAAATTATTAAACATAATTTATTCTAGGTAAAATTTAGATTGTAGTG
AATGTAGGAAGTTCTTCAGCACTTGAGCTGCATTAGAAATTTCATGCCAAAAATGAATTTCATGAATGTGAGGTCACTAGTAATACAGCT
GTTGAAGAATTAGAGGGAAATAGGAAATGATTTTCCCATAATTCCAGAAAGCAAAAGGCTTACAATCCCTGTTGTCTGACCACAGTTTAA
AATTAATTAGAAACTATCAAAAATGTGGCTTAAAAGAAATTAACCACCTAGGAATTTAATATTGTTGTGTATATTTATGTGTGTGTATAA
AACTCCTGTGGGAAAGAAACAAAACATCATTCTATAAGTCAGTATACTTTTGGATGCTCAAAATGCCATATCTTCAACCAGTAGGAGTTG
TTTCAAGTTGAGTTTTTGATGTGATCCCACCAATAATTTGATAGTTTACTTGATTGTGGCTGCATAATTTGGTAACCTATGAAAGATGCT
AGAGCACCAATGTATAATTTTTTTGAGACAGGGTGTCACTTTGTCCCCCAGGCTGGAGTGCAGTGGTACAAGCACAGTTCACTGTACCCT
GTTCCTCCTGGGCTCAAGTGATTCTTCCACCTAAATTTTTTTTTTTTTTTTAGAGAAAGGGTCTCACTATGTTGCCCAGGCTGGTCTTGA
ACTTCTGGGCTCAAGTGATCCTCCCTCCTTGGCCTCCAAAGGTGCTGGGGTTACAGGTATGAGCCACCACACCCAGCCCAACTCATTATT
CTTGAAATCAATAAATCAGAGGAAAAATTGTCATTTAGTTTCCTTTTCCCATGTGAACCAAATTTCAGGGTCACCAGAAGTTCATCAAAT
TCAAATGAATTTGGCCTGGCACAGGGGTCACACCTGTAATCCCAGCACTTTGGGAGGACAAGGTGGGTGGATCACTTGAGGCCAGGAGTT
TGAGACCAACCTGGTTAACATGGTGAAACCCTGTCTGTACTAAAAATACAAAATTTAGCCAGGCATGGTGGCACACACCTGTAGTCCCAG
GCTGAGGTGGGAGGATCACTTGAACCCAAGAGGCAGAGTTTGCAGTGAGCTGAGATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGTG
AGACCCTGTCTCAAAAAAAAAATTTGTTTTTTGAATGGGTTTTTCTTTTTTGAAGAAGTCTAATAAATCTAGAAGGAATTAGAGGATTAG
AAAAATCACCATTTTCTAGACCTTAATGGAATAATGGGTCCAGAAAACATGATCTTCAATGGGTACTACAACTAATAGGTGAAATATTTT
ATAGCGAGATTTTTATGGTGGATCTATCAAACTGGCCACCTCTGAACCCTTTGATCTGTTTTAACCTTAATAAAAATGGGTCTATCAGAC
AACACACTTCCTGACGTAATGCAATAGGAAGTCCACACCACCATCTACAAAGCCTTATTGCTGGAATAATGAACTGAAAGCAGACAGGGA
CTAGATGAACAGTATATGGTCATCCCTTGGTATCCATGGGGAATTGGTTCCAGGATCCTCCACTGATGGTAAAATCTGAGGATGCTCAAG
TCCCTTGTATAAAATGGCATAGTATGTATTTGCATATTACCTACTCACATCTTCCTGTATACTTTAAATTATCTTTAGATCACTTATACC
TATCACAATGTAAATACTATGTAAATAGTTGTTATACTGTATTTTTCAATTTGCATTATTTTTATTGTATTTTATTTTTATTGTTTTTTT
TTGAGTATTTTCTATTTGAGATTGGTTGAATCTGCACATATGGAGGGCTGGCTATAAAGGGCACCACAAGGAAGAAGCCAAACAGATCCA
GAATGTGTGAAATTCTACAGAGCAAATTACCTGATTTCTTCAACTAACAGGTAGCATGAAAATACAAGGGGAAGGGCAACCATTAACAGA
TTAAAAGAGACTTAAAGAGACATATCAACTAAATTCAGTATGTTGGCATTACTTGGACCTGGTTTGAACAAAACATAAAAAGCCATTTTG
GAGACAGTGAGGGAAGTGTGGACATGGACTAAATATTAAATGATATTTACATATATTAATTTGGTTAGGGATTATGTCAGTGTGATTATA
AAAAATAAAAGATCGTATGATATGAGATACATACTATGAAATGAAGATAGACACATTTGGATTAAAATATTCTAGCAAAAGAAATAATTG
GCAAAGAGAGCTGGAAACTAAATTGGCAACATGTTGATAATTTAAGTGGAGTGTTTTGTTCATGGAGACTTATTGTTCTAATATTTCTAC
TTTTGTATGTGTTTGAAATTTCAATAATAAAATGTTTAAAATCAAAACCAAAATTATAGACTATGTAGAAATGAATGACAGTGAGATGCC
TGCACATCTAACCTTGTCAGATATAATCAAAGTTCTGTTCAGTGACAAATTAATGCCCTGTAATGTGGTAAGGAAATCTTATTTGTGGAT
ACAGTCTTCATCTTCTTCACTTACCCACAGCAGCAACACCAGGCCTGTCACACAGATGAATGTGTTGAGGGAATGAATAAGTATTTCCGT
CAAGAAAAAGGAAACAACAAAATAAAACCAACCCAAGTAAAGAACAGCCAAGTGGCCAGGTGCGGTGGCTCATGCCTGTAATCCCAGCAC
TTTGGGAGGCCATGGCAGGTGGATCACCTGAGGTCGGGATTTTGAGACCAGCCTGACCAACACTGAGAAACCCCATCTCTATTAAAGATA
CAAAATTAGCCAGGCATGGTGGTGCATGCCTGTAATCCCAGCTACTTGGGAGGCTAAGGCAGGAGAATCACTTGAATCCAGGAGGCGGAG

>4656_4656_1_ANKRD27-ZFP14_ANKRD27_chr19_33134029_ENST00000306065_ZFP14_chr19_36832492_ENST00000270001_length(amino acids)=454AA_BP=79
MESRYRTNTLSPEKDIYEIYSFQWDIMERIKSYSLQGSIFRNDWECKSKIEGEKEQQEGYFGQVKITSEKMTTYKRHNFLTEYQIVHNGE
KVYECKECRKTFIRRSTLSQHLRIHTGEKPYKCKECGQAFRQRAHLIRHHKLHTGEKPYECKECGKAFTVLQELTQHQRLHTGEKPYECK
ECGKAFRVHQQLARHQRIHTGEKPYECKDCGKTFRQCTHLTRHQRLHTAEKLYECKECGKAFVCGPDLRVHQKIHFGEKPYECKECGKAF
RICQQLTVHQSIHTGEKPYECKECGKTFRLRQQLVRHQRIHTREKPYECMECWKTFSSYSQLISHQSIHIGERPYECEECGKAFRLLSQL
TQHQSIHTGEKPYECKECRKPFRLLSQLTQHQSIHTGEKPYECKECGKAFRLYSFLTQHQRIHTGEKPYKCKECKKAFRQHSHLTQHQKI

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>4656_4656_2_ANKRD27-ZFP14_ANKRD27_chr19_33134029_ENST00000587352_ZFP14_chr19_36832492_ENST00000270001_length(transcript)=6242nt_BP=911nt
GCCGCGCGAGGGTGGTGGGCATCGAGGTCCCAGCAGCGGACGAGGGAGGTGCCGCCGTCGCCCAGGATGGGCTGGGAATGAAGCGATGTA
GCCTTTTAAGAGATTTGCTCTGACCCATCTGAAGTCCATATGGCTCTGTATGATGAAGACCTCCTGAAAAATCCTTTCTATCTGGCTCTG
CAAAAGTGCCGCCCTGACTTGTGCAGCAAAGTGGCCCAAATCCATGGCATTGTCTTAGTACCCTGCAAAGGAAGCCTGTCGAGCAGCATC
CAGTCTACTTGTCAGTTTGAGTCCTACATTTTGATACCTGTGGAAGAGCATTTTCAGACCTTAAATGGAAAGGATGTCTTTATTCAAGGG
AACAGGATTAAATTAGGAGCTGGTTTTGCCTGTCTTCTCTCAGTGCCCATTCTCTTTGAAGAAACTTTCTACAATGAAAAAGAAGAGAGT
TTCAGCATCCTGTGTATAGCCCATCCTTTGGAAAAGAGAGAGAGTTCAGAAGAGCCTTTGGCACCCTCAGATCCCTTTTCCCTGAAAACC
ATTGAAGATGTGAGAGAGTTCTTGGGAAGACACTCCGAGCGATTTGACAGGAACATCGCCTCTTTCCATCGAACATTCCGAGAATGCGAG
AGAAAGAGCCTCCGTCACCACATAGACTCAGCGAATGCTCTCTACACCAAATGCCTCCAGCAGCTTCTGAGGGACTCTCACCTGAAAATG
CTCGCCAAGCAGGAGGCCCAGATGAACCTGATGAAGCAGGCAGTGGAGATATACGTCCATCATGAAATTTACAACCTGATCTTTAAATAC
GTGGGGACCATGGAGGCAAGTGAGGATGCGGCCTTTAACAAAATCACAAGAAGCCTTCAAGATCTTCAGCAGAAAGATATTGGTGTGAAA
CCGGAGTTCAGATTTGGAGTCCAGATACAGGACCAATACTTTATCTCCAGAAAAGGACATTTATGAAATATATTCATTTCAGTGGGATAT
AATGGAAAGAATTAAAAGCTATAGCCTTCAGGGTTCCATTTTTAGGAATGATTGGGAATGCAAAAGCAAGATTGAGGGGGAAAAGGAACA
ACAAGAGGGATATTTTGGGCAAGTGAAAATTACCTCTGAAAAAATGACCACTTACAAAAGGCACAATTTTCTTACTGAGTATCAGATCGT
TCATAATGGAGAAAAGGTGTATGAGTGTAAGGAGTGTAGGAAGACCTTTATTCGTCGCTCAACACTTAGTCAACACCTGAGAATTCATAC
TGGTGAGAAACCTTATAAGTGTAAGGAATGTGGGCAGGCCTTTAGACAGCGTGCACATCTTATTCGACATCACAAACTTCACACCGGTGA
GAAACCCTATGAATGTAAGGAGTGTGGGAAGGCCTTTACAGTGCTCCAAGAACTTACTCAACATCAGAGACTTCATACGGGTGAAAAACC
CTATGAATGTAAGGAATGTGGAAAGGCCTTTAGAGTACATCAGCAACTGGCTCGACATCAGAGAATTCACACTGGTGAGAAACCCTATGA
ATGTAAGGACTGTGGAAAGACCTTTAGACAGTGTACACACCTTACACGCCATCAGAGACTTCATACTGCTGAAAAGCTCTATGAATGTAA
GGAATGTGGGAAAGCCTTCGTATGTGGTCCAGACCTTAGAGTACATCAGAAAATTCATTTTGGTGAGAAACCCTATGAATGTAAGGAGTG
TGGAAAGGCTTTTAGAATATGCCAACAACTTACTGTTCATCAGAGTATTCATACTGGTGAGAAACCCTACGAATGTAAGGAATGTGGGAA
GACTTTTAGATTAAGACAACAACTAGTTCGCCATCAGAGAATACATACTCGTGAGAAACCCTATGAATGTATGGAATGTTGGAAGACCTT
TAGTAGTTACTCACAGCTTATTTCACACCAGAGCATTCATATTGGTGAGAGACCCTATGAATGTGAAGAGTGTGGAAAGGCCTTTAGACT
GCTCTCACAACTTACTCAGCATCAAAGTATTCACACTGGTGAGAAACCTTATGAATGTAAGGAATGTAGAAAACCTTTTAGACTGCTCTC
ACAACTTACCCAACATCAGAGTATTCACACTGGTGAGAAACCTTATGAATGTAAGGAATGTGGTAAGGCTTTTAGACTTTATTCATTTCT
TACTCAACACCAGAGAATTCATACTGGTGAGAAGCCCTACAAGTGTAAGGAGTGTAAGAAGGCCTTTAGACAGCATTCACACCTTACTCA
GCATCAGAAGATTCATAATGGAATTTAATAGAAGAAAGCCTTCAAATGTATATGATGTTACAGAACATCAGAAAATTCATTTTTGAGAAA
ATGTGTTTCATGCTCAATTCCAAGCATAATAAATTTTATATTAGAGAAAGAATATGTTGATTTAAAAGCCTTCCAACACCATTTAAACAT
GGTTTATCTTCAGCAAATTCCTATGAGAGAATAATGTAATGAATGTAGGAAAATCTTTAGCCTTATCTGTCATTATCTCCCTTTCTCCAC
TTGATTACCAGTTTGATTTATTGGACAAGATACTAAGCTTCTGTGCCTCATTTTGCTGACTTGTAAAATGGTAATAATAGTACTTATATG
TATTAGTTATTTATTGCTGCGTAATAAATTACCACAGACTTAGTAGCATAAAATAACATATAATTATATCTTATAATTTGGATCAGGAGT
ATAGGCATGACTTAGTTGGGTCCTCTGCTTCAGGGTCTCTTGCAAGGCTACAGATTTCAGCCAGGGCTGAGGTCTCATCTGAAGGCTCAA
CTGGGGAAGGATCCACATCCAGACTAACATAGTTGTTACCCAATGTATTTCCGTGAGGCCTGTTGCATTGAGATTCTCAGTTTCTAGCTG
GCTGTTGGCTGAACGCTGACTGCAGCTCCTGGCCACAATAGCCTCATCAACATGGCTGCTTGCTTCATCAAGGCATGCAAGCCAAAAGGG
AGGACAGTCTGCTAGCAAGATGGAAGTTACCATCTTGTGTAATCTAATCATGGAAGTAACATTCCCTCACCTTCTACTGGTAGAAGTAAG
TTACTAGGATAGTCCACACTCAAGAGAACGGGATGATACAAGAGTGTGAATAAGTCCTGGAGACAGGACCACTGGGGGGCCTGTTTAGAG
TCAGCCTGCCACACTGTGGAATAGGATTGTTGCAAGGAGTAAGTAGTTAATACTTGGAGGAATCACAGTCATATAGCATGTATTCTGTAA
ATATTATCTGTAATTGTTATTATTGTCATTAGTATTAGTGAATTCACGTAAAAGGAAGATCTGTAGACATAATAAATGTAGAAATGCCTC
CTGTCACCTCTCAGAAATTATTAAACATAATTTATTCTAGGTAAAATTTAGATTGTAGTGAATGTAGGAAGTTCTTCAGCACTTGAGCTG
CATTAGAAATTTCATGCCAAAAATGAATTTCATGAATGTGAGGTCACTAGTAATACAGCTGTTGAAGAATTAGAGGGAAATAGGAAATGA
TTTTCCCATAATTCCAGAAAGCAAAAGGCTTACAATCCCTGTTGTCTGACCACAGTTTAAAATTAATTAGAAACTATCAAAAATGTGGCT
TAAAAGAAATTAACCACCTAGGAATTTAATATTGTTGTGTATATTTATGTGTGTGTATAAAACTCCTGTGGGAAAGAAACAAAACATCAT
TCTATAAGTCAGTATACTTTTGGATGCTCAAAATGCCATATCTTCAACCAGTAGGAGTTGTTTCAAGTTGAGTTTTTGATGTGATCCCAC
CAATAATTTGATAGTTTACTTGATTGTGGCTGCATAATTTGGTAACCTATGAAAGATGCTAGAGCACCAATGTATAATTTTTTTGAGACA
GGGTGTCACTTTGTCCCCCAGGCTGGAGTGCAGTGGTACAAGCACAGTTCACTGTACCCTGTTCCTCCTGGGCTCAAGTGATTCTTCCAC
CTAAATTTTTTTTTTTTTTTTAGAGAAAGGGTCTCACTATGTTGCCCAGGCTGGTCTTGAACTTCTGGGCTCAAGTGATCCTCCCTCCTT
GGCCTCCAAAGGTGCTGGGGTTACAGGTATGAGCCACCACACCCAGCCCAACTCATTATTCTTGAAATCAATAAATCAGAGGAAAAATTG
TCATTTAGTTTCCTTTTCCCATGTGAACCAAATTTCAGGGTCACCAGAAGTTCATCAAATTCAAATGAATTTGGCCTGGCACAGGGGTCA
CACCTGTAATCCCAGCACTTTGGGAGGACAAGGTGGGTGGATCACTTGAGGCCAGGAGTTTGAGACCAACCTGGTTAACATGGTGAAACC
CTGTCTGTACTAAAAATACAAAATTTAGCCAGGCATGGTGGCACACACCTGTAGTCCCAGGCTGAGGTGGGAGGATCACTTGAACCCAAG
AGGCAGAGTTTGCAGTGAGCTGAGATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACCCTGTCTCAAAAAAAAAATTTGTTTT
TTGAATGGGTTTTTCTTTTTTGAAGAAGTCTAATAAATCTAGAAGGAATTAGAGGATTAGAAAAATCACCATTTTCTAGACCTTAATGGA
ATAATGGGTCCAGAAAACATGATCTTCAATGGGTACTACAACTAATAGGTGAAATATTTTATAGCGAGATTTTTATGGTGGATCTATCAA
ACTGGCCACCTCTGAACCCTTTGATCTGTTTTAACCTTAATAAAAATGGGTCTATCAGACAACACACTTCCTGACGTAATGCAATAGGAA
GTCCACACCACCATCTACAAAGCCTTATTGCTGGAATAATGAACTGAAAGCAGACAGGGACTAGATGAACAGTATATGGTCATCCCTTGG
TATCCATGGGGAATTGGTTCCAGGATCCTCCACTGATGGTAAAATCTGAGGATGCTCAAGTCCCTTGTATAAAATGGCATAGTATGTATT
TGCATATTACCTACTCACATCTTCCTGTATACTTTAAATTATCTTTAGATCACTTATACCTATCACAATGTAAATACTATGTAAATAGTT
GTTATACTGTATTTTTCAATTTGCATTATTTTTATTGTATTTTATTTTTATTGTTTTTTTTTGAGTATTTTCTATTTGAGATTGGTTGAA
TCTGCACATATGGAGGGCTGGCTATAAAGGGCACCACAAGGAAGAAGCCAAACAGATCCAGAATGTGTGAAATTCTACAGAGCAAATTAC
CTGATTTCTTCAACTAACAGGTAGCATGAAAATACAAGGGGAAGGGCAACCATTAACAGATTAAAAGAGACTTAAAGAGACATATCAACT
AAATTCAGTATGTTGGCATTACTTGGACCTGGTTTGAACAAAACATAAAAAGCCATTTTGGAGACAGTGAGGGAAGTGTGGACATGGACT
AAATATTAAATGATATTTACATATATTAATTTGGTTAGGGATTATGTCAGTGTGATTATAAAAAATAAAAGATCGTATGATATGAGATAC
ATACTATGAAATGAAGATAGACACATTTGGATTAAAATATTCTAGCAAAAGAAATAATTGGCAAAGAGAGCTGGAAACTAAATTGGCAAC
ATGTTGATAATTTAAGTGGAGTGTTTTGTTCATGGAGACTTATTGTTCTAATATTTCTACTTTTGTATGTGTTTGAAATTTCAATAATAA
AATGTTTAAAATCAAAACCAAAATTATAGACTATGTAGAAATGAATGACAGTGAGATGCCTGCACATCTAACCTTGTCAGATATAATCAA
AGTTCTGTTCAGTGACAAATTAATGCCCTGTAATGTGGTAAGGAAATCTTATTTGTGGATACAGTCTTCATCTTCTTCACTTACCCACAG
CAGCAACACCAGGCCTGTCACACAGATGAATGTGTTGAGGGAATGAATAAGTATTTCCGTCAAGAAAAAGGAAACAACAAAATAAAACCA
ACCCAAGTAAAGAACAGCCAAGTGGCCAGGTGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCATGGCAGGTGGATCACCTG
AGGTCGGGATTTTGAGACCAGCCTGACCAACACTGAGAAACCCCATCTCTATTAAAGATACAAAATTAGCCAGGCATGGTGGTGCATGCC
TGTAATCCCAGCTACTTGGGAGGCTAAGGCAGGAGAATCACTTGAATCCAGGAGGCGGAGTTTGTGGTGAGTTGAGATCGCGCCACTGCA

>4656_4656_2_ANKRD27-ZFP14_ANKRD27_chr19_33134029_ENST00000587352_ZFP14_chr19_36832492_ENST00000270001_length(amino acids)=454AA_BP=79
MESRYRTNTLSPEKDIYEIYSFQWDIMERIKSYSLQGSIFRNDWECKSKIEGEKEQQEGYFGQVKITSEKMTTYKRHNFLTEYQIVHNGE
KVYECKECRKTFIRRSTLSQHLRIHTGEKPYKCKECGQAFRQRAHLIRHHKLHTGEKPYECKECGKAFTVLQELTQHQRLHTGEKPYECK
ECGKAFRVHQQLARHQRIHTGEKPYECKDCGKTFRQCTHLTRHQRLHTAEKLYECKECGKAFVCGPDLRVHQKIHFGEKPYECKECGKAF
RICQQLTVHQSIHTGEKPYECKECGKTFRLRQQLVRHQRIHTREKPYECMECWKTFSSYSQLISHQSIHIGERPYECEECGKAFRLLSQL
TQHQSIHTGEKPYECKECRKPFRLLSQLTQHQSIHTGEKPYECKECGKAFRLYSFLTQHQRIHTGEKPYKCKECKKAFRQHSHLTQHQKI

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Fusion Gene PPI Analysis for ANKRD27-ZFP14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneANKRD27chr19:33134029chr19:36832492ENST00000306065-929451_730260.66666666666671051.0RAB32
HgeneANKRD27chr19:33134029chr19:36832492ENST00000306065-929451_600260.66666666666671051.0RAB38


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANKRD27-ZFP14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANKRD27-ZFP14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource