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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANKRD27-ZNF536 (FusionGDB2 ID:HG84079TG9745)

Fusion Gene Summary for ANKRD27-ZNF536

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD27-ZNF536
Fusion gene ID: hg84079tg9745
HgeneTgene
Gene symbol

ANKRD27

ZNF536

Gene ID

84079

9745

Gene nameankyrin repeat domain 27zinc finger protein 536
SynonymsPP12899|VARP-
Cytomap('ANKRD27')('ZNF536')

19q13.11

19q12

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat domain-containing protein 27VPS9 domain-containing proteinVPS9-ankyrin-repeat proteinVps9 domain and ankyrin-repeat-containing proteinankyrin repeat domain 27 (VPS9 domain)zinc finger protein 536
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000306065, ENST00000587352, 
Fusion gene scores* DoF score14 X 14 X 8=156821 X 13 X 13=3549
# samples 1625
** MAII scorelog2(16/1568*10)=-3.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(25/3549*10)=-3.82741257439886
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANKRD27 [Title/Abstract] AND ZNF536 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANKRD27(33098541)-ZNF536(31025754), # samples:3
Anticipated loss of major functional domain due to fusion event.ANKRD27-ZNF536 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD27-ZNF536 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD27-ZNF536 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD27-ZNF536 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANKRD27

GO:0035544

negative regulation of SNARE complex assembly

24856514

HgeneANKRD27

GO:0045022

early endosome to late endosome transport

16525121

TgeneZNF536

GO:0000122

negative regulation of transcription by RNA polymerase II

19398580


check buttonFusion gene breakpoints across ANKRD27 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ZNF536 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-37-A5EN-01AANKRD27chr19

33098541

-ZNF536chr19

31025754

+
ChimerDB4LUSCTCGA-37-A5ENANKRD27chr19

33098541

-ZNF536chr19

31025754

+


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Fusion Gene ORF analysis for ANKRD27-ZNF536

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000306065ENST00000590564ANKRD27chr19

33098541

-ZNF536chr19

31025754

+
In-frameENST00000306065ENST00000355537ANKRD27chr19

33098541

-ZNF536chr19

31025754

+
intron-3CDSENST00000587352ENST00000355537ANKRD27chr19

33098541

-ZNF536chr19

31025754

+
intron-intronENST00000587352ENST00000590564ANKRD27chr19

33098541

-ZNF536chr19

31025754

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000306065ANKRD27chr1933098541-ENST00000355537ZNF536chr1931025754+516025321592612817

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000306065ENST00000355537ANKRD27chr1933098541-ZNF536chr1931025754+0.003326760.9966732

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Fusion Genomic Features for ANKRD27-ZNF536


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ANKRD27chr1933098540-ZNF536chr1931025753+2.42E-081
ANKRD27chr1933098540-ZNF536chr1931025753+2.42E-081
ANKRD27chr1933098540-ZNF536chr1931025753+2.42E-081
ANKRD27chr1933098540-ZNF536chr1931025753+2.42E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ANKRD27-ZNF536


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:33098541/chr19:31025754)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD27chr19:33098541chr19:31025754ENST00000306065-2329233_3717911051.0DomainVPS9
HgeneANKRD27chr19:33098541chr19:31025754ENST00000306065-23291_3727911051.0RegionSufficient for GEF activity towards RAB21
HgeneANKRD27chr19:33098541chr19:31025754ENST00000306065-2329396_4267911051.0RepeatNote=ANK 1
HgeneANKRD27chr19:33098541chr19:31025754ENST00000306065-2329462_4917911051.0RepeatNote=ANK 2
HgeneANKRD27chr19:33098541chr19:31025754ENST00000306065-2329495_5247911051.0RepeatNote=ANK 3
HgeneANKRD27chr19:33098541chr19:31025754ENST00000306065-2329528_5607911051.0RepeatNote=ANK 4
HgeneANKRD27chr19:33098541chr19:31025754ENST00000306065-2329564_5937911051.0RepeatNote=ANK 5
HgeneANKRD27chr19:33098541chr19:31025754ENST00000306065-2329597_6277911051.0RepeatNote=ANK 6
HgeneANKRD27chr19:33098541chr19:31025754ENST00000306065-2329668_6987911051.0RepeatNote=ANK 7
HgeneANKRD27chr19:33098541chr19:31025754ENST00000306065-2329743_7727911051.0RepeatNote=ANK 8
TgeneZNF536chr19:33098541chr19:31025754ENST0000035553715751_7737231301.0Zinc fingerC2H2-type 8
TgeneZNF536chr19:33098541chr19:31025754ENST0000035553715779_8017231301.0Zinc fingerC2H2-type 9

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD27chr19:33098541chr19:31025754ENST00000306065-2329776_8057911051.0RepeatNote=ANK 9
HgeneANKRD27chr19:33098541chr19:31025754ENST00000306065-2329809_8387911051.0RepeatNote=ANK 10
HgeneANKRD27chr19:33098541chr19:31025754ENST00000306065-2329842_8717911051.0RepeatNote=ANK 11
TgeneZNF536chr19:33098541chr19:31025754ENST0000035553715130_1527231301.0Zinc fingerC2H2-type 1
TgeneZNF536chr19:33098541chr19:31025754ENST0000035553715158_1807231301.0Zinc fingerC2H2-type 2
TgeneZNF536chr19:33098541chr19:31025754ENST0000035553715274_2977231301.0Zinc fingerC2H2-type 3
TgeneZNF536chr19:33098541chr19:31025754ENST0000035553715300_3237231301.0Zinc fingerC2H2-type 4
TgeneZNF536chr19:33098541chr19:31025754ENST0000035553715345_3677231301.0Zinc fingerC2H2-type 5
TgeneZNF536chr19:33098541chr19:31025754ENST0000035553715373_3957231301.0Zinc fingerC2H2-type 6
TgeneZNF536chr19:33098541chr19:31025754ENST0000035553715631_6537231301.0Zinc fingerC2H2-type 7


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Fusion Gene Sequence for ANKRD27-ZNF536


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4657_4657_1_ANKRD27-ZNF536_ANKRD27_chr19_33098541_ENST00000306065_ZNF536_chr19_31025754_ENST00000355537_length(transcript)=5160nt_BP=2532nt
GGAGTAAGGGGTGGGCTATAGGGCCAGATCGCCGCGCGAGGGTGGTGGGCATCGAGGTCCCAGCAGCGGACGAGGGAGGTGCCGCCGTCG
CCCAGGATGGGCTGGGAATGAAGCGATGTAGCCTTTTAAGAGATTTGCTCTGACCCATCTGAAGTCCATATGGCTCTGTATGATGAAGAC
CTCCTGAAAAATCCTTTCTATCTGGCTCTGCAAAAGTGCCGCCCTGACTTGTGCAGCAAAGTGGCCCAAATCCATGGCATTGTCTTAGTA
CCCTGCAAAGGAAGCCTGTCGAGCAGCATCCAGTCTACTTGTCAGTTTGAGTCCTACATTTTGATACCTGTGGAAGAGCATTTTCAGACC
TTAAATGGAAAGGATGTCTTTATTCAAGGGAACAGGATTAAATTAGGAGCTGGTTTTGCCTGTCTTCTCTCAGTGCCCATTCTCTTTGAA
GAAACTTTCTACAATGAAAAAGAAGAGAGTTTCAGCATCCTGTGTATAGCCCATCCTTTGGAAAAGAGAGAGAGTTCAGAAGAGCCTTTG
GCACCCTCAGATCCCTTTTCCCTGAAAACCATTGAAGATGTGAGAGAGTTCTTGGGAAGACACTCCGAGCGATTTGACAGGAACATCGCC
TCTTTCCATCGAACATTCCGAGAATGCGAGAGAAAGAGCCTCCGTCACCACATAGACTCAGCGAATGCTCTCTACACCAAATGCCTCCAG
CAGCTTCTGAGGGACTCTCACCTGAAAATGCTCGCCAAGCAGGAGGCCCAGATGAACCTGATGAAGCAGGCAGTGGAGATATACGTCCAT
CATGAAATTTACAACCTGATCTTTAAATACGTGGGGACCATGGAGGCAAGTGAGGATGCGGCCTTTAACAAAATCACAAGAAGCCTTCAA
GATCTTCAGCAGAAAGATATTGGTGTGAAACCGGAGTTCAGCTTTAACATACCTCGTGCCAAAAGAGAGCTGGCTCAGCTGAACAAATGC
ACCTCCCCACAGCAGAAGCTTGTCTGCTTGCGAAAAGTGGTGCAGCTCATTACACAGTCTCCAAGCCAGAGAGTGAACCTGGAGACCATG
TGTGCTGATGATCTGCTATCAGTCCTGTTATACTTGCTTGTGAAAACGGAGATCCCTAATTGGATGGCAAATTTGAGTTACATCAAAAAC
TTCAGGTTTAGCAGCTTGGCAAAGGATGAACTGGGATACTGCCTGACCTCATTCGAAGCTGCCATTGAATATATTCGGCAAGGAAGCCTC
TCTGCTAAACCCCCTGAGTCTGAGGGATTTGGAGACAGGCTGTTCCTTAAGCAGAGAATGAGCTTACTCTCTCAGATGACTTCGTCTCCC
ACCGACTGCCTGTTTAAGCACATTGCATCAGGTAACCAGAAAGAAGTGGAGAGACTTCTGAGCCAAGAGGACCATGATAAAGATACCGTC
CAAAAGATGTGTCACCCTCTCTGCTTCTGCGATGACTGTGAGAAACTCGTCTCTGGGAGGTTGAATGATCCCTCAGTTGTCACTCCATTC
TCCAGAGACGACAGGGGGCACACCCCTCTCCATGTGGCTGCTGTCTGTGGGCAGGCATCCCTCATCGACCTCCTGGTTTCCAAGGGCGCC
ATGGTAAATGCCACAGACTACCATGGAGCCACTCCGCTCCACCTGGCCTGTCAGAAGGGCTACCAGAGCGTGACGCTGCTGCTGCTGCAC
TACAAGGCCAGCGCGGAAGTGCAGGACAACAATGGGAATACGCCACTCCACCTGGCCTGCACCTACGGCCACGAGGACTGTGTGAAGGCT
CTGGTTTACTACGACGTGGAGTCGTGCAGACTTGACATTGGCAATGAGAAAGGAGACACCCCTCTACACATTGCTGCCCGCTGGGGCTAC
CAAGGCGTCATAGAGACATTGCTGCAGAACGGAGCGTCCACCGAGATCCAGAACAGACTGAAGGAGACGCCCCTCAAGTGTGCATTAAAC
TCAAAGATTCTGTCTGTAATGGAAGCCTATCACCTGTCCTTCGAGAGGAGGCAGAAGTCGTCCGAGGCCCCTGTGCAGTCCCCGCAGCGC
TCCGTGGACTCCATCAGCCAAGAGTCCTCCACTTCCAGCTTCTCCTCCATGTCAGCCAGCTCAAGGCAGGAGGAGACCAAGAAGGACTAC
AGAGAGGTAGAAAAACTTTTGAGAGCAGTTGCTGATGGAGATCTAGAAATGGTGCGTTACCTGTTGGAATGGACAGAGGAGGACCTGGAG
GATGCGGAGGACACTGTCAGTGCAGCGGACCCCGAATTCTGTCACCCGTTGTGCCAGTGCCCCAAGTGTGCCCCAGCTCAGAAGAGGCTG
GCGAAGGTTCCTGCCAGTGGGCTTGGTGTGAACGTGACCAGCCAGGACGGCTCCTCCCCGCTGCATGTCGCCGCCCTGCACGGCCGGGCG
GACCTCATCCCCCTCCTGCTGAAGCACGGGGCCAACGCAGGTGCCAGGAACGCAGACCAAGCCGTCCCGCTCCACCTGGCCTGCCAGCAG
GGCCACTTTCAGACATTGGCGAGGAGGCTGGGAGATCTGCCGGCGTCCAGCAACCAGCGCTGCTTCGCGACAGAAGCCTGGGCTCGGCCA
TGAAGGACTGCCCGTACTGTGGGAAAACTTTCCGGACATCCCATCACCTTAAGGTGCACCTGAGGATACACACAGGTGAGAAACCCTACA
AGTGTCCGCACTGTGACTATGCCGGCACGCAGTCAGCATCCTTAAAATACCACTTAGAGCGACACCATCGGGAGCGGCAGAACGGGGCTG
GGCCGCTGTCTGGGCAACCCCCAAATCAAGACCACAAGGATGAGATGTCAAGCAAAGCTTCTCTGTTCATCAGGCCAGACATCCTGAGGG
GGGCCTTCAAGGGTCTCCCTGGAATCGACTTCAGAGGAGGCCCTGCATCTCAGCAGTGGACATCAGGGGTTCTCTCCTCTGGAGATCACT
CGGGGCAGGCCACGGGCATGTCTTCGGAGGTCCCCTCAGATGCTCTGAAAGGCACTGACCTTCCTTCCAAAAGCACCCACTTCTCTGAGA
TCGGAAGAGCTTATCAAAGCATTGTGAGCAACGGTGTGAATTTCCAAGGGTCCTTGCAAGCTTTCATGGACAGTTTTGTCCTCAGTTCCT
TGAAGAAGGAGAAGGACATGAAGGACAAAGCCCTGGCTGACCCCCCTTCCATGAAAGTCCACGGAGTGGATGGTGGTGAGGAGAAACCCA
GTGGCAAGTCCTCCCAGAGGAAGTCCGAGAAATCTCAGTATGAACCCCTGGACTTGTCTGTGCGGCCAGATGCCGCCTCCCTCCCGGGCT
CCTCGGTAACTGTGCAGGACAGCATTGCATGGCACGGCTGCTTGTTTTGTGCTTTCACAACGTCCTCCATGGAGCTCATGGCCCTTCATC
TCCAGGCCAACCACCTGGGCAAAGCGAAACGCAAAGATAACACCATCGGGGTCACAGTCAACTGCAAAGACCAAGCCCGGGAGGCGAGTA
AGATGGCCCTGCTGCCCTCGTTACAATCAAACAAAGACCTGGGCCTCTCCAATATGATCAGCTCTCTAGACTCTGCTTCTGAGAAGATGG
CCCAAGGTCAGCTCAAGGAGACTCTGGGAGAGCAGAAGAGCGGTGCATGGACCGGCCACGTGGACCCTGCATTTTGTAACTTCCCATCAG
ACTTCTACAAGCAGTTTGGTGTTTACCCAGGCATGGTTGGCTCAGGGGCCTCCAGTTCCTGCCCCAACAAGGAGCCTGATGGAAAGGCCC
ACTCTGAAGAGGATGTCCCCATCCTGATCCCCGAAACCACGAGTAAGAACACTACTGATGACCTCTCTGACATTGCCTCCTCAGAGGACA
TGGACTCCTCCAAGGGGGAGAACAACGATGAAGAGGATGTTGAAACCGAACCGGAAATGATGACCAAGCCACTGTCTGCCCTCAGCAAAG
ACAGCAGCAGCGATGGCGGGGACAGCCTGCAGCCCACAGGCACCTCCCAGCCCGTCCAGGGACTGGTCTCACCTTTATCCCAAGCACCGG
AGAAGCAGTGGCACAGCCAGGGTCTTCTCCAAGCCCAGGACCCCTTGGCGGGCCTGCCAAAGCCGGAGCGGGGGCCCCAGAGCCTGGACA
AGCCGATGAACATGCTGTCGGTCCTCAGGGCCTACAGTTCTGATGGCTTAGCAGCCTTTAACGGACTTGCAAGTAGCACAGCAAATTCTG
GATGTATCAAGAGGCCAGACTTGTGTGGTAAGTGACACTCCCTGTCCTAGTCGGTCTATCTGGACTTGCCCTTGTCTGTTCGTGGTCCTC
GGTGGTTATCTGCAGCTTGTTAATCGTGTAAAGTCAAGAGAAGAATGTATACACATATGTGTGTTGAATAATTACTATTGGCATAGGTAT
GTGTATACACACGGTGCACCAATCTACAGTATATATAGCAGAGAATCAGAGGCTAAAAATATTACCCCATATGTTCCAGTATTAGTCATG
GATTGCAAAGGCTTAGTAACTTGAGCAGGAGAGAAAACTCCCTCAAAGTCATAAATCCTGAGTGACAACTGCTGCTGGATGACAGATCCC
TTCACCTGTGGACAACCTGGCTGGGGGTGGGGGGCTGTTCCACCAGCTCACCTGAGCATGTAGAGGTGGGTCCTGCAGTGGTCTCGTGGG
TATTACTGCTTGTGTCTGATTGTCCTGTATTTTGTAACACTTTAGAAGAATACAGAAAAGTGCAGTAATTCTCTTTCTCCATAGTATTTA
AGCAGAAATATTGCTAGTTTAATATTGTGTCAGGTCGTCCTATTAACCAGGAGCAGATGACAGTAAAATTTCAGTGAATAGCACCTTGAC
ATCTACAACTTAAAAATGGTGATTGAAGCAAAATATGTAAACTTGTACGGGGTGATCGTGTGCTTTGGAACAGAGTATTGTTGAAGTAAT
TAGAAGATATATTAAGGTGTTCCTGGTAATGAAGGCATGTAAGTTATAATAATTGTAGCTTTCTGAATAAGTGTCAAACTATATCTTTAA
GTGTGCTGTATGCTGAGTTACAAGTTAGGTCATTTATGAATGGAATGTAAAATAATACTAAAAATGCTTCAATAACTTATCTTGGTATTG

>4657_4657_1_ANKRD27-ZNF536_ANKRD27_chr19_33098541_ENST00000306065_ZNF536_chr19_31025754_ENST00000355537_length(amino acids)=817AA_BP=790
MALYDEDLLKNPFYLALQKCRPDLCSKVAQIHGIVLVPCKGSLSSSIQSTCQFESYILIPVEEHFQTLNGKDVFIQGNRIKLGAGFACLL
SVPILFEETFYNEKEESFSILCIAHPLEKRESSEEPLAPSDPFSLKTIEDVREFLGRHSERFDRNIASFHRTFRECERKSLRHHIDSANA
LYTKCLQQLLRDSHLKMLAKQEAQMNLMKQAVEIYVHHEIYNLIFKYVGTMEASEDAAFNKITRSLQDLQQKDIGVKPEFSFNIPRAKRE
LAQLNKCTSPQQKLVCLRKVVQLITQSPSQRVNLETMCADDLLSVLLYLLVKTEIPNWMANLSYIKNFRFSSLAKDELGYCLTSFEAAIE
YIRQGSLSAKPPESEGFGDRLFLKQRMSLLSQMTSSPTDCLFKHIASGNQKEVERLLSQEDHDKDTVQKMCHPLCFCDDCEKLVSGRLND
PSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYG
HEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEA
PVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKC
APAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQTLARRLGDLPASSNQRCFA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ANKRD27-ZNF536


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneANKRD27chr19:33098541chr19:31025754ENST00000306065-2329451_730791.01051.0RAB32
HgeneANKRD27chr19:33098541chr19:31025754ENST00000306065-2329451_600791.01051.0RAB38


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANKRD27-ZNF536


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANKRD27-ZNF536


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0007134Renal Cell Carcinoma1CTD_human
TgeneC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
TgeneC1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneC1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneC1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneC1306837Papillary Renal Cell Carcinoma1CTD_human