|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:BCAR3-ABCA4 (FusionGDB2 ID:HG8412TG24) |
Fusion Gene Summary for BCAR3-ABCA4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BCAR3-ABCA4 | Fusion gene ID: hg8412tg24 | Hgene | Tgene | Gene symbol | BCAR3 | ABCA4 | Gene ID | 8412 | 24 |
| Gene name | BCAR3 adaptor protein, NSP family member | ATP binding cassette subfamily A member 4 | |
| Synonyms | AND-34|NSP2|SH2D3B | ABC10|ABCR|ARMD2|CORD3|FFM|RMP|RP19|STGD|STGD1 | |
| Cytomap | ('BCAR3')('ABCA4') 1p22.1 | 1p22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | breast cancer anti-estrogen resistance protein 3BCAR3, NSP family adaptor proteinSH2 domain-containing protein 3Bbreast cancer anti-estrogen resistance 3breast cancer antiestrogen resistance 3 proteindJ1033H22.2 (breast cancer anti-estrogen resistanc | retinal-specific phospholipid-transporting ATPase ABCA4ATP binding cassette transporterATP-binding cassette sub-family A member 4ATP-binding cassette transporter, retinal-specificATP-binding cassette, sub-family A (ABC1), member 4ATP-binding transpor | |
| Modification date | 20200313 | 20200315 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000260502, ENST00000370243, ENST00000370244, ENST00000370247, ENST00000466632, ENST00000539242, | ||
| Fusion gene scores | * DoF score | 11 X 12 X 9=1188 | 4 X 5 X 5=100 |
| # samples | 12 | 7 | |
| ** MAII score | log2(12/1188*10)=-3.30742852519225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/100*10)=-0.514573172829758 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: BCAR3 [Title/Abstract] AND ABCA4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | BCAR3(94054534)-ABCA4(94495187), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | BCAR3-ABCA4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BCAR3-ABCA4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BCAR3-ABCA4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BCAR3-ABCA4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BCAR3-ABCA4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. BCAR3-ABCA4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ABCA4 | GO:0045332 | phospholipid translocation | 24097981 |
| Fusion gene breakpoints across BCAR3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across ABCA4 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LIHC | TCGA-ZS-A9CF-02A | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - |
| ChimerDB4 | UCEC | TCGA-AJ-A3EJ-01A | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - |
| ChimerDB4 | UCEC | TCGA-AJ-A3EJ | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - |
Top |
Fusion Gene ORF analysis for BCAR3-ABCA4 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000260502 | ENST00000465352 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - |
| 5CDS-intron | ENST00000260502 | ENST00000465352 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - |
| 5CDS-intron | ENST00000260502 | ENST00000535735 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - |
| 5CDS-intron | ENST00000260502 | ENST00000535735 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - |
| 5CDS-intron | ENST00000260502 | ENST00000535881 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - |
| 5CDS-intron | ENST00000260502 | ENST00000535881 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - |
| 5CDS-intron | ENST00000260502 | ENST00000536513 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - |
| 5CDS-intron | ENST00000260502 | ENST00000536513 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - |
| 5CDS-intron | ENST00000370243 | ENST00000465352 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - |
| 5CDS-intron | ENST00000370243 | ENST00000465352 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - |
| 5CDS-intron | ENST00000370243 | ENST00000535735 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - |
| 5CDS-intron | ENST00000370243 | ENST00000535735 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - |
| 5CDS-intron | ENST00000370243 | ENST00000535881 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - |
| 5CDS-intron | ENST00000370243 | ENST00000535881 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - |
| 5CDS-intron | ENST00000370243 | ENST00000536513 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - |
| 5CDS-intron | ENST00000370243 | ENST00000536513 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - |
| 5CDS-intron | ENST00000370244 | ENST00000465352 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - |
| 5CDS-intron | ENST00000370244 | ENST00000465352 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - |
| 5CDS-intron | ENST00000370244 | ENST00000535735 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - |
| 5CDS-intron | ENST00000370244 | ENST00000535735 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - |
| 5CDS-intron | ENST00000370244 | ENST00000535881 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - |
| 5CDS-intron | ENST00000370244 | ENST00000535881 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - |
| 5CDS-intron | ENST00000370244 | ENST00000536513 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - |
| 5CDS-intron | ENST00000370244 | ENST00000536513 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - |
| 5CDS-intron | ENST00000370247 | ENST00000465352 | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - |
| 5CDS-intron | ENST00000370247 | ENST00000465352 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - |
| 5CDS-intron | ENST00000370247 | ENST00000465352 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - |
| 5CDS-intron | ENST00000370247 | ENST00000535735 | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - |
| 5CDS-intron | ENST00000370247 | ENST00000535735 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - |
| 5CDS-intron | ENST00000370247 | ENST00000535735 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - |
| 5CDS-intron | ENST00000370247 | ENST00000535881 | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - |
| 5CDS-intron | ENST00000370247 | ENST00000535881 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - |
| 5CDS-intron | ENST00000370247 | ENST00000535881 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - |
| 5CDS-intron | ENST00000370247 | ENST00000536513 | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - |
| 5CDS-intron | ENST00000370247 | ENST00000536513 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - |
| 5CDS-intron | ENST00000370247 | ENST00000536513 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - |
| Frame-shift | ENST00000260502 | ENST00000370225 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - |
| Frame-shift | ENST00000260502 | ENST00000370225 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - |
| Frame-shift | ENST00000370244 | ENST00000370225 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - |
| Frame-shift | ENST00000370244 | ENST00000370225 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - |
| In-frame | ENST00000370243 | ENST00000370225 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - |
| In-frame | ENST00000370243 | ENST00000370225 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - |
| In-frame | ENST00000370247 | ENST00000370225 | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - |
| In-frame | ENST00000370247 | ENST00000370225 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - |
| In-frame | ENST00000370247 | ENST00000370225 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - |
| intron-3CDS | ENST00000260502 | ENST00000370225 | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - |
| intron-3CDS | ENST00000370243 | ENST00000370225 | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - |
| intron-3CDS | ENST00000370244 | ENST00000370225 | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - |
| intron-3CDS | ENST00000466632 | ENST00000370225 | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - |
| intron-3CDS | ENST00000466632 | ENST00000370225 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - |
| intron-3CDS | ENST00000466632 | ENST00000370225 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - |
| intron-3CDS | ENST00000539242 | ENST00000370225 | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - |
| intron-3CDS | ENST00000539242 | ENST00000370225 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - |
| intron-3CDS | ENST00000539242 | ENST00000370225 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - |
| intron-intron | ENST00000260502 | ENST00000465352 | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - |
| intron-intron | ENST00000260502 | ENST00000535735 | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - |
| intron-intron | ENST00000260502 | ENST00000535881 | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - |
| intron-intron | ENST00000260502 | ENST00000536513 | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - |
| intron-intron | ENST00000370243 | ENST00000465352 | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - |
| intron-intron | ENST00000370243 | ENST00000535735 | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - |
| intron-intron | ENST00000370243 | ENST00000535881 | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - |
| intron-intron | ENST00000370243 | ENST00000536513 | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - |
| intron-intron | ENST00000370244 | ENST00000465352 | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - |
| intron-intron | ENST00000370244 | ENST00000535735 | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - |
| intron-intron | ENST00000370244 | ENST00000535881 | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - |
| intron-intron | ENST00000370244 | ENST00000536513 | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - |
| intron-intron | ENST00000466632 | ENST00000465352 | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - |
| intron-intron | ENST00000466632 | ENST00000465352 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - |
| intron-intron | ENST00000466632 | ENST00000465352 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - |
| intron-intron | ENST00000466632 | ENST00000535735 | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - |
| intron-intron | ENST00000466632 | ENST00000535735 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - |
| intron-intron | ENST00000466632 | ENST00000535735 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - |
| intron-intron | ENST00000466632 | ENST00000535881 | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - |
| intron-intron | ENST00000466632 | ENST00000535881 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - |
| intron-intron | ENST00000466632 | ENST00000535881 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - |
| intron-intron | ENST00000466632 | ENST00000536513 | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - |
| intron-intron | ENST00000466632 | ENST00000536513 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - |
| intron-intron | ENST00000466632 | ENST00000536513 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - |
| intron-intron | ENST00000539242 | ENST00000465352 | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - |
| intron-intron | ENST00000539242 | ENST00000465352 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - |
| intron-intron | ENST00000539242 | ENST00000465352 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - |
| intron-intron | ENST00000539242 | ENST00000535735 | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - |
| intron-intron | ENST00000539242 | ENST00000535735 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - |
| intron-intron | ENST00000539242 | ENST00000535735 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - |
| intron-intron | ENST00000539242 | ENST00000535881 | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - |
| intron-intron | ENST00000539242 | ENST00000535881 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - |
| intron-intron | ENST00000539242 | ENST00000535881 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - |
| intron-intron | ENST00000539242 | ENST00000536513 | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - |
| intron-intron | ENST00000539242 | ENST00000536513 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - |
| intron-intron | ENST00000539242 | ENST00000536513 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000370243 | BCAR3 | chr1 | 94054534 | - | ENST00000370225 | ABCA4 | chr1 | 94495187 | - | 4074 | 1204 | 68 | 3673 | 1201 |
| ENST00000370247 | BCAR3 | chr1 | 94054534 | - | ENST00000370225 | ABCA4 | chr1 | 94495187 | - | 3693 | 823 | 167 | 3292 | 1041 |
| ENST00000370243 | BCAR3 | chr1 | 94054533 | - | ENST00000370225 | ABCA4 | chr1 | 94495187 | - | 4074 | 1204 | 68 | 3673 | 1201 |
| ENST00000370247 | BCAR3 | chr1 | 94054533 | - | ENST00000370225 | ABCA4 | chr1 | 94495187 | - | 3693 | 823 | 167 | 3292 | 1041 |
| ENST00000370247 | BCAR3 | chr1 | 94079404 | - | ENST00000370225 | ABCA4 | chr1 | 94505683 | - | 3951 | 251 | 167 | 3550 | 1127 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000370243 | ENST00000370225 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - | 0.001855568 | 0.9981444 |
| ENST00000370247 | ENST00000370225 | BCAR3 | chr1 | 94054534 | - | ABCA4 | chr1 | 94495187 | - | 0.001294702 | 0.99870527 |
| ENST00000370243 | ENST00000370225 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - | 0.001855568 | 0.9981444 |
| ENST00000370247 | ENST00000370225 | BCAR3 | chr1 | 94054533 | - | ABCA4 | chr1 | 94495187 | - | 0.001294702 | 0.99870527 |
| ENST00000370247 | ENST00000370225 | BCAR3 | chr1 | 94079404 | - | ABCA4 | chr1 | 94505683 | - | 0.001484465 | 0.99851555 |
Top |
Fusion Genomic Features for BCAR3-ABCA4 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
 |
Top |
Fusion Protein Features for BCAR3-ABCA4 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:94054534/chr1:94495187) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | BCAR3 | chr1:94054533 | chr1:94495187 | ENST00000260502 | - | 5 | 12 | 154_253 | 309 | 826.0 | Domain | SH2 |
| Hgene | BCAR3 | chr1:94054533 | chr1:94495187 | ENST00000370243 | - | 5 | 12 | 154_253 | 309 | 826.0 | Domain | SH2 |
| Hgene | BCAR3 | chr1:94054533 | chr1:94495187 | ENST00000370244 | - | 7 | 14 | 154_253 | 309 | 826.0 | Domain | SH2 |
| Hgene | BCAR3 | chr1:94054534 | chr1:94495187 | ENST00000260502 | - | 5 | 12 | 154_253 | 309 | 826.0 | Domain | SH2 |
| Hgene | BCAR3 | chr1:94054534 | chr1:94495187 | ENST00000370243 | - | 5 | 12 | 154_253 | 309 | 826.0 | Domain | SH2 |
| Hgene | BCAR3 | chr1:94054534 | chr1:94495187 | ENST00000370244 | - | 7 | 14 | 154_253 | 309 | 826.0 | Domain | SH2 |
| Tgene | ABCA4 | chr1:94054533 | chr1:94495187 | ENST00000370225 | 28 | 50 | 1938_2170 | 1450 | 2274.0 | Domain | ABC transporter 2 | |
| Tgene | ABCA4 | chr1:94054534 | chr1:94495187 | ENST00000370225 | 28 | 50 | 1938_2170 | 1450 | 2274.0 | Domain | ABC transporter 2 | |
| Tgene | ABCA4 | chr1:94079404 | chr1:94505683 | ENST00000370225 | 22 | 50 | 1938_2170 | 1174 | 2274.0 | Domain | ABC transporter 2 | |
| Tgene | ABCA4 | chr1:94054533 | chr1:94495187 | ENST00000370225 | 28 | 50 | 1972_1979 | 1450 | 2274.0 | Nucleotide binding | ATP 2 | |
| Tgene | ABCA4 | chr1:94054534 | chr1:94495187 | ENST00000370225 | 28 | 50 | 1972_1979 | 1450 | 2274.0 | Nucleotide binding | ATP 2 | |
| Tgene | ABCA4 | chr1:94079404 | chr1:94505683 | ENST00000370225 | 22 | 50 | 1972_1979 | 1174 | 2274.0 | Nucleotide binding | ATP 2 | |
| Tgene | ABCA4 | chr1:94054533 | chr1:94495187 | ENST00000370225 | 28 | 50 | 1895_2273 | 1450 | 2274.0 | Topological domain | Note=Cytoplasmic | |
| Tgene | ABCA4 | chr1:94054534 | chr1:94495187 | ENST00000370225 | 28 | 50 | 1895_2273 | 1450 | 2274.0 | Topological domain | Note=Cytoplasmic | |
| Tgene | ABCA4 | chr1:94079404 | chr1:94505683 | ENST00000370225 | 22 | 50 | 1398_1727 | 1174 | 2274.0 | Topological domain | Note=Extracellular | |
| Tgene | ABCA4 | chr1:94079404 | chr1:94505683 | ENST00000370225 | 22 | 50 | 1895_2273 | 1174 | 2274.0 | Topological domain | Note=Cytoplasmic | |
| Tgene | ABCA4 | chr1:94054533 | chr1:94495187 | ENST00000370225 | 28 | 50 | 1728_1748 | 1450 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94054533 | chr1:94495187 | ENST00000370225 | 28 | 50 | 1760_1780 | 1450 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94054533 | chr1:94495187 | ENST00000370225 | 28 | 50 | 1793_1813 | 1450 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94054533 | chr1:94495187 | ENST00000370225 | 28 | 50 | 1832_1852 | 1450 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94054533 | chr1:94495187 | ENST00000370225 | 28 | 50 | 1874_1894 | 1450 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94054534 | chr1:94495187 | ENST00000370225 | 28 | 50 | 1728_1748 | 1450 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94054534 | chr1:94495187 | ENST00000370225 | 28 | 50 | 1760_1780 | 1450 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94054534 | chr1:94495187 | ENST00000370225 | 28 | 50 | 1793_1813 | 1450 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94054534 | chr1:94495187 | ENST00000370225 | 28 | 50 | 1832_1852 | 1450 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94054534 | chr1:94495187 | ENST00000370225 | 28 | 50 | 1874_1894 | 1450 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94079404 | chr1:94505683 | ENST00000370225 | 22 | 50 | 1377_1397 | 1174 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94079404 | chr1:94505683 | ENST00000370225 | 22 | 50 | 1728_1748 | 1174 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94079404 | chr1:94505683 | ENST00000370225 | 22 | 50 | 1760_1780 | 1174 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94079404 | chr1:94505683 | ENST00000370225 | 22 | 50 | 1793_1813 | 1174 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94079404 | chr1:94505683 | ENST00000370225 | 22 | 50 | 1832_1852 | 1174 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94079404 | chr1:94505683 | ENST00000370225 | 22 | 50 | 1874_1894 | 1174 | 2274.0 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | BCAR3 | chr1:94054533 | chr1:94495187 | ENST00000260502 | - | 5 | 12 | 479_482 | 309 | 826.0 | Compositional bias | Note=Poly-Asp |
| Hgene | BCAR3 | chr1:94054533 | chr1:94495187 | ENST00000370243 | - | 5 | 12 | 479_482 | 309 | 826.0 | Compositional bias | Note=Poly-Asp |
| Hgene | BCAR3 | chr1:94054533 | chr1:94495187 | ENST00000370244 | - | 7 | 14 | 479_482 | 309 | 826.0 | Compositional bias | Note=Poly-Asp |
| Hgene | BCAR3 | chr1:94054533 | chr1:94495187 | ENST00000370247 | - | 3 | 10 | 479_482 | 218 | 735.0 | Compositional bias | Note=Poly-Asp |
| Hgene | BCAR3 | chr1:94054533 | chr1:94495187 | ENST00000539242 | - | 1 | 8 | 479_482 | 0 | 502.0 | Compositional bias | Note=Poly-Asp |
| Hgene | BCAR3 | chr1:94054534 | chr1:94495187 | ENST00000260502 | - | 5 | 12 | 479_482 | 309 | 826.0 | Compositional bias | Note=Poly-Asp |
| Hgene | BCAR3 | chr1:94054534 | chr1:94495187 | ENST00000370243 | - | 5 | 12 | 479_482 | 309 | 826.0 | Compositional bias | Note=Poly-Asp |
| Hgene | BCAR3 | chr1:94054534 | chr1:94495187 | ENST00000370244 | - | 7 | 14 | 479_482 | 309 | 826.0 | Compositional bias | Note=Poly-Asp |
| Hgene | BCAR3 | chr1:94054534 | chr1:94495187 | ENST00000370247 | - | 3 | 10 | 479_482 | 218 | 735.0 | Compositional bias | Note=Poly-Asp |
| Hgene | BCAR3 | chr1:94054534 | chr1:94495187 | ENST00000539242 | - | 1 | 8 | 479_482 | 0 | 502.0 | Compositional bias | Note=Poly-Asp |
| Hgene | BCAR3 | chr1:94079404 | chr1:94505683 | ENST00000260502 | - | 1 | 12 | 479_482 | 0 | 826.0 | Compositional bias | Note=Poly-Asp |
| Hgene | BCAR3 | chr1:94079404 | chr1:94505683 | ENST00000370243 | - | 1 | 12 | 479_482 | 0 | 826.0 | Compositional bias | Note=Poly-Asp |
| Hgene | BCAR3 | chr1:94079404 | chr1:94505683 | ENST00000370244 | - | 1 | 14 | 479_482 | 0 | 826.0 | Compositional bias | Note=Poly-Asp |
| Hgene | BCAR3 | chr1:94079404 | chr1:94505683 | ENST00000370247 | - | 1 | 10 | 479_482 | 28 | 735.0 | Compositional bias | Note=Poly-Asp |
| Hgene | BCAR3 | chr1:94079404 | chr1:94505683 | ENST00000539242 | - | 1 | 8 | 479_482 | 0 | 502.0 | Compositional bias | Note=Poly-Asp |
| Hgene | BCAR3 | chr1:94054533 | chr1:94495187 | ENST00000260502 | - | 5 | 12 | 548_818 | 309 | 826.0 | Domain | Ras-GEF |
| Hgene | BCAR3 | chr1:94054533 | chr1:94495187 | ENST00000370243 | - | 5 | 12 | 548_818 | 309 | 826.0 | Domain | Ras-GEF |
| Hgene | BCAR3 | chr1:94054533 | chr1:94495187 | ENST00000370244 | - | 7 | 14 | 548_818 | 309 | 826.0 | Domain | Ras-GEF |
| Hgene | BCAR3 | chr1:94054533 | chr1:94495187 | ENST00000370247 | - | 3 | 10 | 154_253 | 218 | 735.0 | Domain | SH2 |
| Hgene | BCAR3 | chr1:94054533 | chr1:94495187 | ENST00000370247 | - | 3 | 10 | 548_818 | 218 | 735.0 | Domain | Ras-GEF |
| Hgene | BCAR3 | chr1:94054533 | chr1:94495187 | ENST00000539242 | - | 1 | 8 | 154_253 | 0 | 502.0 | Domain | SH2 |
| Hgene | BCAR3 | chr1:94054533 | chr1:94495187 | ENST00000539242 | - | 1 | 8 | 548_818 | 0 | 502.0 | Domain | Ras-GEF |
| Hgene | BCAR3 | chr1:94054534 | chr1:94495187 | ENST00000260502 | - | 5 | 12 | 548_818 | 309 | 826.0 | Domain | Ras-GEF |
| Hgene | BCAR3 | chr1:94054534 | chr1:94495187 | ENST00000370243 | - | 5 | 12 | 548_818 | 309 | 826.0 | Domain | Ras-GEF |
| Hgene | BCAR3 | chr1:94054534 | chr1:94495187 | ENST00000370244 | - | 7 | 14 | 548_818 | 309 | 826.0 | Domain | Ras-GEF |
| Hgene | BCAR3 | chr1:94054534 | chr1:94495187 | ENST00000370247 | - | 3 | 10 | 154_253 | 218 | 735.0 | Domain | SH2 |
| Hgene | BCAR3 | chr1:94054534 | chr1:94495187 | ENST00000370247 | - | 3 | 10 | 548_818 | 218 | 735.0 | Domain | Ras-GEF |
| Hgene | BCAR3 | chr1:94054534 | chr1:94495187 | ENST00000539242 | - | 1 | 8 | 154_253 | 0 | 502.0 | Domain | SH2 |
| Hgene | BCAR3 | chr1:94054534 | chr1:94495187 | ENST00000539242 | - | 1 | 8 | 548_818 | 0 | 502.0 | Domain | Ras-GEF |
| Hgene | BCAR3 | chr1:94079404 | chr1:94505683 | ENST00000260502 | - | 1 | 12 | 154_253 | 0 | 826.0 | Domain | SH2 |
| Hgene | BCAR3 | chr1:94079404 | chr1:94505683 | ENST00000260502 | - | 1 | 12 | 548_818 | 0 | 826.0 | Domain | Ras-GEF |
| Hgene | BCAR3 | chr1:94079404 | chr1:94505683 | ENST00000370243 | - | 1 | 12 | 154_253 | 0 | 826.0 | Domain | SH2 |
| Hgene | BCAR3 | chr1:94079404 | chr1:94505683 | ENST00000370243 | - | 1 | 12 | 548_818 | 0 | 826.0 | Domain | Ras-GEF |
| Hgene | BCAR3 | chr1:94079404 | chr1:94505683 | ENST00000370244 | - | 1 | 14 | 154_253 | 0 | 826.0 | Domain | SH2 |
| Hgene | BCAR3 | chr1:94079404 | chr1:94505683 | ENST00000370244 | - | 1 | 14 | 548_818 | 0 | 826.0 | Domain | Ras-GEF |
| Hgene | BCAR3 | chr1:94079404 | chr1:94505683 | ENST00000370247 | - | 1 | 10 | 154_253 | 28 | 735.0 | Domain | SH2 |
| Hgene | BCAR3 | chr1:94079404 | chr1:94505683 | ENST00000370247 | - | 1 | 10 | 548_818 | 28 | 735.0 | Domain | Ras-GEF |
| Hgene | BCAR3 | chr1:94079404 | chr1:94505683 | ENST00000539242 | - | 1 | 8 | 154_253 | 0 | 502.0 | Domain | SH2 |
| Hgene | BCAR3 | chr1:94079404 | chr1:94505683 | ENST00000539242 | - | 1 | 8 | 548_818 | 0 | 502.0 | Domain | Ras-GEF |
| Tgene | ABCA4 | chr1:94054533 | chr1:94495187 | ENST00000370225 | 28 | 50 | 929_1160 | 1450 | 2274.0 | Domain | ABC transporter 1 | |
| Tgene | ABCA4 | chr1:94054534 | chr1:94495187 | ENST00000370225 | 28 | 50 | 929_1160 | 1450 | 2274.0 | Domain | ABC transporter 1 | |
| Tgene | ABCA4 | chr1:94079404 | chr1:94505683 | ENST00000370225 | 22 | 50 | 929_1160 | 1174 | 2274.0 | Domain | ABC transporter 1 | |
| Tgene | ABCA4 | chr1:94054533 | chr1:94495187 | ENST00000370225 | 28 | 50 | 963_970 | 1450 | 2274.0 | Nucleotide binding | ATP 1 | |
| Tgene | ABCA4 | chr1:94054534 | chr1:94495187 | ENST00000370225 | 28 | 50 | 963_970 | 1450 | 2274.0 | Nucleotide binding | ATP 1 | |
| Tgene | ABCA4 | chr1:94079404 | chr1:94505683 | ENST00000370225 | 22 | 50 | 963_970 | 1174 | 2274.0 | Nucleotide binding | ATP 1 | |
| Tgene | ABCA4 | chr1:94054533 | chr1:94495187 | ENST00000370225 | 28 | 50 | 1398_1727 | 1450 | 2274.0 | Topological domain | Note=Extracellular | |
| Tgene | ABCA4 | chr1:94054533 | chr1:94495187 | ENST00000370225 | 28 | 50 | 1_21 | 1450 | 2274.0 | Topological domain | Note=Cytoplasmic | |
| Tgene | ABCA4 | chr1:94054533 | chr1:94495187 | ENST00000370225 | 28 | 50 | 43_646 | 1450 | 2274.0 | Topological domain | Note=Extracellular | |
| Tgene | ABCA4 | chr1:94054533 | chr1:94495187 | ENST00000370225 | 28 | 50 | 857_1376 | 1450 | 2274.0 | Topological domain | Note=Cytoplasmic | |
| Tgene | ABCA4 | chr1:94054534 | chr1:94495187 | ENST00000370225 | 28 | 50 | 1398_1727 | 1450 | 2274.0 | Topological domain | Note=Extracellular | |
| Tgene | ABCA4 | chr1:94054534 | chr1:94495187 | ENST00000370225 | 28 | 50 | 1_21 | 1450 | 2274.0 | Topological domain | Note=Cytoplasmic | |
| Tgene | ABCA4 | chr1:94054534 | chr1:94495187 | ENST00000370225 | 28 | 50 | 43_646 | 1450 | 2274.0 | Topological domain | Note=Extracellular | |
| Tgene | ABCA4 | chr1:94054534 | chr1:94495187 | ENST00000370225 | 28 | 50 | 857_1376 | 1450 | 2274.0 | Topological domain | Note=Cytoplasmic | |
| Tgene | ABCA4 | chr1:94079404 | chr1:94505683 | ENST00000370225 | 22 | 50 | 1_21 | 1174 | 2274.0 | Topological domain | Note=Cytoplasmic | |
| Tgene | ABCA4 | chr1:94079404 | chr1:94505683 | ENST00000370225 | 22 | 50 | 43_646 | 1174 | 2274.0 | Topological domain | Note=Extracellular | |
| Tgene | ABCA4 | chr1:94079404 | chr1:94505683 | ENST00000370225 | 22 | 50 | 857_1376 | 1174 | 2274.0 | Topological domain | Note=Cytoplasmic | |
| Tgene | ABCA4 | chr1:94054533 | chr1:94495187 | ENST00000370225 | 28 | 50 | 1377_1397 | 1450 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94054533 | chr1:94495187 | ENST00000370225 | 28 | 50 | 22_42 | 1450 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94054533 | chr1:94495187 | ENST00000370225 | 28 | 50 | 647_667 | 1450 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94054533 | chr1:94495187 | ENST00000370225 | 28 | 50 | 700_720 | 1450 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94054533 | chr1:94495187 | ENST00000370225 | 28 | 50 | 731_751 | 1450 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94054533 | chr1:94495187 | ENST00000370225 | 28 | 50 | 760_780 | 1450 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94054533 | chr1:94495187 | ENST00000370225 | 28 | 50 | 836_856 | 1450 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94054534 | chr1:94495187 | ENST00000370225 | 28 | 50 | 1377_1397 | 1450 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94054534 | chr1:94495187 | ENST00000370225 | 28 | 50 | 22_42 | 1450 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94054534 | chr1:94495187 | ENST00000370225 | 28 | 50 | 647_667 | 1450 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94054534 | chr1:94495187 | ENST00000370225 | 28 | 50 | 700_720 | 1450 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94054534 | chr1:94495187 | ENST00000370225 | 28 | 50 | 731_751 | 1450 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94054534 | chr1:94495187 | ENST00000370225 | 28 | 50 | 760_780 | 1450 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94054534 | chr1:94495187 | ENST00000370225 | 28 | 50 | 836_856 | 1450 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94079404 | chr1:94505683 | ENST00000370225 | 22 | 50 | 22_42 | 1174 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94079404 | chr1:94505683 | ENST00000370225 | 22 | 50 | 647_667 | 1174 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94079404 | chr1:94505683 | ENST00000370225 | 22 | 50 | 700_720 | 1174 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94079404 | chr1:94505683 | ENST00000370225 | 22 | 50 | 731_751 | 1174 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94079404 | chr1:94505683 | ENST00000370225 | 22 | 50 | 760_780 | 1174 | 2274.0 | Transmembrane | Helical | |
| Tgene | ABCA4 | chr1:94079404 | chr1:94505683 | ENST00000370225 | 22 | 50 | 836_856 | 1174 | 2274.0 | Transmembrane | Helical |
Top |
Fusion Gene Sequence for BCAR3-ABCA4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >9162_9162_1_BCAR3-ABCA4_BCAR3_chr1_94054533_ENST00000370243_ABCA4_chr1_94495187_ENST00000370225_length(transcript)=4074nt_BP=1204nt GAGCGCGCTGGGACTCCCCGAGACGTGGCCCACGGCGGGGAGCGCTCAGCGATTGGCGGCCAGGCATCTTGCTCGGTGGCACTCGAGCGG CATCTTCCCGGGCGCTGGCCTCGCCCGACCCCCTGCCCGTCGGAGCTGCTCTGCCGGCCACCCCGCCCTGTCCCGCCCGTCCCCTCTTCG CAGAAGCCGGCCGGGGTCGGGCAGATGCGAGGGCCCAGAGCGCTCTGGTGGAAGCCCAAGGCTCCGAGGAGGCGAGTTTCTCCGAGTTGA GAATTATGGCTGCAGGAAAATTTGCAAGCCTTCCCAGAAACATGCCGGTGAATCACCAGTTCCCCCTGGCCTCATCCATGGACCTTCTGA GCAGCAGGTCCCCTCTCGCTGAGCATCGCCCAGATGCCTATCAAGATGTGTCTATACATGGCACCCTTCCACGGAAGAAAAAAGGTCCTC CTCCCATAAGGTCCTGTGATGACTTCAGTCACATGGGCACCCTCCCCCACTCCAAATCCCCACGGCAGAACTCGCCTGTGACCCAGGATG GCATCCAGGAGAGCCCATGGCAGGACCGGCACGGCGAAACCTTCACCTTCAGGGATCCACATCTTCTGGACCCAACTGTGGAATATGTGA AGTTCTCCAAGGAGAGGCACATCATGGACAGGACCCCCGAGAAACTGAAGAAGGAGCTGGAGGAGGAGCTGCTCCTGAGCAGCGAGGACC TGCGCAGCCATGCCTGGTACCACGGCCGCATCCCCCGACAGGTGTCTGAAAACCTTGTGCAGCGAGATGGTGACTTCCTAGTTCGTGACT CTCTGTCCAGCCCTGGGAACTTTGTCCTGACCTGTCAGTGGAAGAACCTCGCTCAGCACTTCAAAATCAACCGGACAGTTCTGCGACTCA GCGAGGCCTACAGCCGCGTGCAGTACCAGTTCGAGATGGAGAGCTTCGACTCCATCCCCGGCCTGGTGCGCTGCTACGTGGGCAACCGCC GGCCCATCTCCCAGCAGAGTGGCGCCATCATCTTCCAGCCCATCAACAGGACGGTGCCTCTGCGGTGCCTGGAGGAGCATTATGGCACCT CCCCAGGCCAGGCCCGGGAGGGCAGCCTCACCAAGGGAAGGCCGGATGTGGCCAAGAGGCTGAGCCTCACCATGGGTGGCGTCCAGGCCC GAGAGCAGAATTTGCCCAGGGGAAACCTCCTCAGGGAGTACCCCTGTGGCAACTCAACACCCTGGAAGACTCCTTCTGTGTCCCCAAACA TCACCCAGCTGTTCCAGAAGCAGAAATGGACACAGGTCAACCCTTCACCATCCTGCAGGTGCAGCACCAGGGAGAAGCTCACCATGCTGC CAGAGTGCCCCGAGGGTGCCGGGGGCCTCCCGCCCCCCCAGAGAACACAGCGCAGCACGGAAATTCTACAAGACCTGACGGACAGGAACA TCTCCGACTTCTTGGTAAAAACGTATCCTGCTCTTATAAGAAGCAGCTTAAAGAGCAAATTCTGGGTCAATGAACAGAGGTATGGAGGAA TTTCCATTGGAGGAAAGCTCCCAGTCGTCCCCATCACGGGGGAAGCACTTGTTGGGTTTTTAAGCGACCTTGGCCGGATCATGAATGTGA GCGGGGGCCCTATCACTAGAGAGGCCTCTAAAGAAATACCTGATTTCCTTAAACATCTAGAAACTGAAGACAACATTAAGGTGTGGTTTA ATAACAAAGGCTGGCATGCCCTGGTCAGCTTTCTCAATGTGGCCCACAACGCCATCTTACGGGCCAGCCTGCCTAAGGACAGGAGCCCCG AGGAGTATGGAATCACCGTCATTAGCCAACCCCTGAACCTGACCAAGGAGCAGCTCTCAGAGATTACAGTGCTGACCACTTCAGTGGATG CTGTGGTTGCCATCTGCGTGATTTTCTCCATGTCCTTCGTCCCAGCCAGCTTTGTCCTTTATTTGATCCAGGAGCGGGTGAACAAATCCA AGCACCTCCAGTTTATCAGTGGAGTGAGCCCCACCACCTACTGGGTGACCAACTTCCTCTGGGACATCATGAATTATTCCGTGAGTGCTG GGCTGGTGGTGGGCATCTTCATCGGGTTTCAGAAGAAAGCCTACACTTCTCCAGAAAACCTTCCTGCCCTTGTGGCACTGCTCCTGCTGT ATGGATGGGCGGTCATTCCCATGATGTACCCAGCATCCTTCCTGTTTGATGTCCCCAGCACAGCCTATGTGGCTTTATCTTGTGCTAATC TGTTCATCGGCATCAACAGCAGTGCTATTACCTTCATCTTGGAATTATTTGAGAATAACCGGACGCTGCTCAGGTTCAACGCCGTGCTGA GGAAGCTGCTCATTGTCTTCCCCCACTTCTGCCTGGGCCGGGGCCTCATTGACCTTGCACTGAGCCAGGCTGTGACAGATGTCTATGCCC GGTTTGGTGAGGAGCACTCTGCAAATCCGTTCCACTGGGACCTGATTGGGAAGAACCTGTTTGCCATGGTGGTGGAAGGGGTGGTGTACT TCCTCCTGACCCTGCTGGTCCAGCGCCACTTCTTCCTCTCCCAATGGATTGCCGAGCCCACTAAGGAGCCCATTGTTGATGAAGATGATG ATGTGGCTGAAGAAAGACAAAGAATTATTACTGGTGGAAATAAAACTGACATCTTAAGGCTACATGAACTAACCAAGATTTATCCAGGCA CCTCCAGCCCAGCAGTGGACAGGCTGTGTGTCGGAGTTCGCCCTGGAGAGTGCTTTGGCCTCCTGGGAGTGAATGGTGCCGGCAAAACAA CCACATTCAAGATGCTCACTGGGGACACCACAGTGACCTCAGGGGATGCCACCGTAGCAGGCAAGAGTATTTTAACCAATATTTCTGAAG TCCATCAAAATATGGGCTACTGTCCTCAGTTTGATGCAATTGATGAGCTGCTCACAGGACGAGAACATCTTTACCTTTATGCCCGGCTTC GAGGTGTACCAGCAGAAGAAATCGAAAAGGTTGCAAACTGGAGTATTAAGAGCCTGGGCCTGACTGTCTACGCCGACTGCCTGGCTGGCA CGTACAGTGGGGGCAACAAGCGGAAACTCTCCACAGCCATCGCACTCATTGGCTGCCCACCGCTGGTGCTGCTGGATGAGCCCACCACAG GGATGGACCCCCAGGCACGCCGCATGCTGTGGAACGTCATCGTGAGCATCATCAGAGAAGGGAGGGCTGTGGTCCTCACATCCCACAGCA TGGAAGAATGTGAGGCACTGTGTACCCGGCTGGCCATCATGGTAAAGGGCGCCTTTCGATGTATGGGCACCATTCAGCATCTCAAGTCCA AATTTGGAGATGGCTATATCGTCACAATGAAGATCAAATCCCCGAAGGACGACCTGCTTCCTGACCTGAACCCTGTGGAGCAGTTCTTCC AGGGGAACTTCCCAGGCAGTGTGCAGAGGGAGAGGCACTACAACATGCTCCAGTTCCAGGTCTCCTCCTCCTCCCTGGCGAGGATCTTCC AGCTCCTCCTCTCCCACAAGGACAGCCTGCTCATCGAGGAGTACTCAGTCACACAGACCACACTGGACCAGGTGTTTGTAAATTTTGCTA AACAGCAGACTGAAAGTCATGACCTCCCTCTGCACCCTCGAGCTGCTGGAGCCAGTCGACAAGCCCAGGACTGATCTTTCACACCGCTCG TTCCTGCAGCCAGAAAGGAACTCTGGGCAGCTGGAGGCGCAGGAGCCTGTGCCCATATGGTCATCCAAATGGACTGGCCAGCGTAAATGA CCCCACTGCAGCAGAAAACAAACACACGAGGAGCATGCAGCGAATTCAGAAAGAGGTCTTTCAGAAGGAAACCGAAACTGACTTGCTCAC CTGGAACACCTGATGGTGAAACCAAACAAATACAAAATCCTTCTCCAGACCCCAGAACTAGAAACCCCGGGCCATCCCACTAGCAGCTTT GGCCTCCATATTGCTCTCATTTCAAGCAGATCTGCTTTTCTGCATGTTTGTCTGTGTGTCTGCGTTGTGTGTGATTTTCATGGAAAAATA >9162_9162_1_BCAR3-ABCA4_BCAR3_chr1_94054533_ENST00000370243_ABCA4_chr1_94495187_ENST00000370225_length(amino acids)=1201AA_BP=378 MLGGTRAASSRALASPDPLPVGAALPATPPCPARPLFAEAGRGRADARAQSALVEAQGSEEASFSELRIMAAGKFASLPRNMPVNHQFPL ASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPPIRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLL DPTVEYVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKI NRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSL TMGGVQAREQNLPRGNLLREYPCGNSTPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLPECPEGAGGLPPPQRTQRSTEIL QDLTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPVVPITGEALVGFLSDLGRIMNVSGGPITREASKEIPDFLKHLETE DNIKVWFNNKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVVAICVIFSMSFVPASFVLYLI QERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPSTAY VALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGEEHSANPFHWDLIGKNLFAM VVEGVVYFLLTLLVQRHFFLSQWIAEPTKEPIVDEDDDVAEERQRIITGGNKTDILRLHELTKIYPGTSSPAVDRLCVGVRPGECFGLLG VNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTV YADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMG TIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSLARIFQLLLSHKDSLLIEEYSVTQTTLD -------------------------------------------------------------- >9162_9162_2_BCAR3-ABCA4_BCAR3_chr1_94054533_ENST00000370247_ABCA4_chr1_94495187_ENST00000370225_length(transcript)=3693nt_BP=823nt AGACTAGCCTGGGAGAAGGAGCCGACTCACTCCCCCGGCTGCCGACTTCCCTGACTTCTGGGCAGAAACAGCACAGCTGCTGTGGTGGGC TAGGGCTTTAACGTCCGAAGCCCCCTTTCTTTTAACCCTAAAGAAAGTGTGTGGTCCCCGGGACTGAAGACCGAAAGATGCCTAAGGAAT GCAGTGCTTTCCACGCCCTCTCAGCAGCTCTGTGCTGCTTCTATCACCGCAAGTCTTTCATTGGAGTCAAGTTCTCCAAGGAGAGGCACA TCATGGACAGGACCCCCGAGAAACTGAAGAAGGAGCTGGAGGAGGAGCTGCTCCTGAGCAGCGAGGACCTGCGCAGCCATGCCTGGTACC ACGGCCGCATCCCCCGACAGGTGTCTGAAAACCTTGTGCAGCGAGATGGTGACTTCCTAGTTCGTGACTCTCTGTCCAGCCCTGGGAACT TTGTCCTGACCTGTCAGTGGAAGAACCTCGCTCAGCACTTCAAAATCAACCGGACAGTTCTGCGACTCAGCGAGGCCTACAGCCGCGTGC AGTACCAGTTCGAGATGGAGAGCTTCGACTCCATCCCCGGCCTGGTGCGCTGCTACGTGGGCAACCGCCGGCCCATCTCCCAGCAGAGTG GCGCCATCATCTTCCAGCCCATCAACAGGACGGTGCCTCTGCGGTGCCTGGAGGAGCATTATGGCACCTCCCCAGGCCAGGCCCGGGAGG GCAGCCTCACCAAGGGAAGGCCGGATGTGGCCAAGAGGCTGAGCCTCACCATGGGTGGCGTCCAGGCCCGAGAGCAGAATTTGCCCAGGG GAAACCTCCTCAGGGAGTACCCCTGTGGCAACTCAACACCCTGGAAGACTCCTTCTGTGTCCCCAAACATCACCCAGCTGTTCCAGAAGC AGAAATGGACACAGGTCAACCCTTCACCATCCTGCAGGTGCAGCACCAGGGAGAAGCTCACCATGCTGCCAGAGTGCCCCGAGGGTGCCG GGGGCCTCCCGCCCCCCCAGAGAACACAGCGCAGCACGGAAATTCTACAAGACCTGACGGACAGGAACATCTCCGACTTCTTGGTAAAAA CGTATCCTGCTCTTATAAGAAGCAGCTTAAAGAGCAAATTCTGGGTCAATGAACAGAGGTATGGAGGAATTTCCATTGGAGGAAAGCTCC CAGTCGTCCCCATCACGGGGGAAGCACTTGTTGGGTTTTTAAGCGACCTTGGCCGGATCATGAATGTGAGCGGGGGCCCTATCACTAGAG AGGCCTCTAAAGAAATACCTGATTTCCTTAAACATCTAGAAACTGAAGACAACATTAAGGTGTGGTTTAATAACAAAGGCTGGCATGCCC TGGTCAGCTTTCTCAATGTGGCCCACAACGCCATCTTACGGGCCAGCCTGCCTAAGGACAGGAGCCCCGAGGAGTATGGAATCACCGTCA TTAGCCAACCCCTGAACCTGACCAAGGAGCAGCTCTCAGAGATTACAGTGCTGACCACTTCAGTGGATGCTGTGGTTGCCATCTGCGTGA TTTTCTCCATGTCCTTCGTCCCAGCCAGCTTTGTCCTTTATTTGATCCAGGAGCGGGTGAACAAATCCAAGCACCTCCAGTTTATCAGTG GAGTGAGCCCCACCACCTACTGGGTGACCAACTTCCTCTGGGACATCATGAATTATTCCGTGAGTGCTGGGCTGGTGGTGGGCATCTTCA TCGGGTTTCAGAAGAAAGCCTACACTTCTCCAGAAAACCTTCCTGCCCTTGTGGCACTGCTCCTGCTGTATGGATGGGCGGTCATTCCCA TGATGTACCCAGCATCCTTCCTGTTTGATGTCCCCAGCACAGCCTATGTGGCTTTATCTTGTGCTAATCTGTTCATCGGCATCAACAGCA GTGCTATTACCTTCATCTTGGAATTATTTGAGAATAACCGGACGCTGCTCAGGTTCAACGCCGTGCTGAGGAAGCTGCTCATTGTCTTCC CCCACTTCTGCCTGGGCCGGGGCCTCATTGACCTTGCACTGAGCCAGGCTGTGACAGATGTCTATGCCCGGTTTGGTGAGGAGCACTCTG CAAATCCGTTCCACTGGGACCTGATTGGGAAGAACCTGTTTGCCATGGTGGTGGAAGGGGTGGTGTACTTCCTCCTGACCCTGCTGGTCC AGCGCCACTTCTTCCTCTCCCAATGGATTGCCGAGCCCACTAAGGAGCCCATTGTTGATGAAGATGATGATGTGGCTGAAGAAAGACAAA GAATTATTACTGGTGGAAATAAAACTGACATCTTAAGGCTACATGAACTAACCAAGATTTATCCAGGCACCTCCAGCCCAGCAGTGGACA GGCTGTGTGTCGGAGTTCGCCCTGGAGAGTGCTTTGGCCTCCTGGGAGTGAATGGTGCCGGCAAAACAACCACATTCAAGATGCTCACTG GGGACACCACAGTGACCTCAGGGGATGCCACCGTAGCAGGCAAGAGTATTTTAACCAATATTTCTGAAGTCCATCAAAATATGGGCTACT GTCCTCAGTTTGATGCAATTGATGAGCTGCTCACAGGACGAGAACATCTTTACCTTTATGCCCGGCTTCGAGGTGTACCAGCAGAAGAAA TCGAAAAGGTTGCAAACTGGAGTATTAAGAGCCTGGGCCTGACTGTCTACGCCGACTGCCTGGCTGGCACGTACAGTGGGGGCAACAAGC GGAAACTCTCCACAGCCATCGCACTCATTGGCTGCCCACCGCTGGTGCTGCTGGATGAGCCCACCACAGGGATGGACCCCCAGGCACGCC GCATGCTGTGGAACGTCATCGTGAGCATCATCAGAGAAGGGAGGGCTGTGGTCCTCACATCCCACAGCATGGAAGAATGTGAGGCACTGT GTACCCGGCTGGCCATCATGGTAAAGGGCGCCTTTCGATGTATGGGCACCATTCAGCATCTCAAGTCCAAATTTGGAGATGGCTATATCG TCACAATGAAGATCAAATCCCCGAAGGACGACCTGCTTCCTGACCTGAACCCTGTGGAGCAGTTCTTCCAGGGGAACTTCCCAGGCAGTG TGCAGAGGGAGAGGCACTACAACATGCTCCAGTTCCAGGTCTCCTCCTCCTCCCTGGCGAGGATCTTCCAGCTCCTCCTCTCCCACAAGG ACAGCCTGCTCATCGAGGAGTACTCAGTCACACAGACCACACTGGACCAGGTGTTTGTAAATTTTGCTAAACAGCAGACTGAAAGTCATG ACCTCCCTCTGCACCCTCGAGCTGCTGGAGCCAGTCGACAAGCCCAGGACTGATCTTTCACACCGCTCGTTCCTGCAGCCAGAAAGGAAC TCTGGGCAGCTGGAGGCGCAGGAGCCTGTGCCCATATGGTCATCCAAATGGACTGGCCAGCGTAAATGACCCCACTGCAGCAGAAAACAA ACACACGAGGAGCATGCAGCGAATTCAGAAAGAGGTCTTTCAGAAGGAAACCGAAACTGACTTGCTCACCTGGAACACCTGATGGTGAAA CCAAACAAATACAAAATCCTTCTCCAGACCCCAGAACTAGAAACCCCGGGCCATCCCACTAGCAGCTTTGGCCTCCATATTGCTCTCATT TCAAGCAGATCTGCTTTTCTGCATGTTTGTCTGTGTGTCTGCGTTGTGTGTGATTTTCATGGAAAAATAAAATGCAAATGCACTCATCAC >9162_9162_2_BCAR3-ABCA4_BCAR3_chr1_94054533_ENST00000370247_ABCA4_chr1_94495187_ENST00000370225_length(amino acids)=1041AA_BP=218 MPKECSAFHALSAALCCFYHRKSFIGVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLS SPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEEHYGTSPG QAREGSLTKGRPDVAKRLSLTMGGVQAREQNLPRGNLLREYPCGNSTPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLPEC PEGAGGLPPPQRTQRSTEILQDLTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPVVPITGEALVGFLSDLGRIMNVSGG PITREASKEIPDFLKHLETEDNIKVWFNNKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVV AICVIFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGW AVIPMMYPASFLFDVPSTAYVALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFG EEHSANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRHFFLSQWIAEPTKEPIVDEDDDVAEERQRIITGGNKTDILRLHELTKIYPGTSS PAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGV PAEEIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEE CEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSLARIFQLL -------------------------------------------------------------- >9162_9162_3_BCAR3-ABCA4_BCAR3_chr1_94054534_ENST00000370243_ABCA4_chr1_94495187_ENST00000370225_length(transcript)=4074nt_BP=1204nt GAGCGCGCTGGGACTCCCCGAGACGTGGCCCACGGCGGGGAGCGCTCAGCGATTGGCGGCCAGGCATCTTGCTCGGTGGCACTCGAGCGG CATCTTCCCGGGCGCTGGCCTCGCCCGACCCCCTGCCCGTCGGAGCTGCTCTGCCGGCCACCCCGCCCTGTCCCGCCCGTCCCCTCTTCG CAGAAGCCGGCCGGGGTCGGGCAGATGCGAGGGCCCAGAGCGCTCTGGTGGAAGCCCAAGGCTCCGAGGAGGCGAGTTTCTCCGAGTTGA GAATTATGGCTGCAGGAAAATTTGCAAGCCTTCCCAGAAACATGCCGGTGAATCACCAGTTCCCCCTGGCCTCATCCATGGACCTTCTGA GCAGCAGGTCCCCTCTCGCTGAGCATCGCCCAGATGCCTATCAAGATGTGTCTATACATGGCACCCTTCCACGGAAGAAAAAAGGTCCTC CTCCCATAAGGTCCTGTGATGACTTCAGTCACATGGGCACCCTCCCCCACTCCAAATCCCCACGGCAGAACTCGCCTGTGACCCAGGATG GCATCCAGGAGAGCCCATGGCAGGACCGGCACGGCGAAACCTTCACCTTCAGGGATCCACATCTTCTGGACCCAACTGTGGAATATGTGA AGTTCTCCAAGGAGAGGCACATCATGGACAGGACCCCCGAGAAACTGAAGAAGGAGCTGGAGGAGGAGCTGCTCCTGAGCAGCGAGGACC TGCGCAGCCATGCCTGGTACCACGGCCGCATCCCCCGACAGGTGTCTGAAAACCTTGTGCAGCGAGATGGTGACTTCCTAGTTCGTGACT CTCTGTCCAGCCCTGGGAACTTTGTCCTGACCTGTCAGTGGAAGAACCTCGCTCAGCACTTCAAAATCAACCGGACAGTTCTGCGACTCA GCGAGGCCTACAGCCGCGTGCAGTACCAGTTCGAGATGGAGAGCTTCGACTCCATCCCCGGCCTGGTGCGCTGCTACGTGGGCAACCGCC GGCCCATCTCCCAGCAGAGTGGCGCCATCATCTTCCAGCCCATCAACAGGACGGTGCCTCTGCGGTGCCTGGAGGAGCATTATGGCACCT CCCCAGGCCAGGCCCGGGAGGGCAGCCTCACCAAGGGAAGGCCGGATGTGGCCAAGAGGCTGAGCCTCACCATGGGTGGCGTCCAGGCCC GAGAGCAGAATTTGCCCAGGGGAAACCTCCTCAGGGAGTACCCCTGTGGCAACTCAACACCCTGGAAGACTCCTTCTGTGTCCCCAAACA TCACCCAGCTGTTCCAGAAGCAGAAATGGACACAGGTCAACCCTTCACCATCCTGCAGGTGCAGCACCAGGGAGAAGCTCACCATGCTGC CAGAGTGCCCCGAGGGTGCCGGGGGCCTCCCGCCCCCCCAGAGAACACAGCGCAGCACGGAAATTCTACAAGACCTGACGGACAGGAACA TCTCCGACTTCTTGGTAAAAACGTATCCTGCTCTTATAAGAAGCAGCTTAAAGAGCAAATTCTGGGTCAATGAACAGAGGTATGGAGGAA TTTCCATTGGAGGAAAGCTCCCAGTCGTCCCCATCACGGGGGAAGCACTTGTTGGGTTTTTAAGCGACCTTGGCCGGATCATGAATGTGA GCGGGGGCCCTATCACTAGAGAGGCCTCTAAAGAAATACCTGATTTCCTTAAACATCTAGAAACTGAAGACAACATTAAGGTGTGGTTTA ATAACAAAGGCTGGCATGCCCTGGTCAGCTTTCTCAATGTGGCCCACAACGCCATCTTACGGGCCAGCCTGCCTAAGGACAGGAGCCCCG AGGAGTATGGAATCACCGTCATTAGCCAACCCCTGAACCTGACCAAGGAGCAGCTCTCAGAGATTACAGTGCTGACCACTTCAGTGGATG CTGTGGTTGCCATCTGCGTGATTTTCTCCATGTCCTTCGTCCCAGCCAGCTTTGTCCTTTATTTGATCCAGGAGCGGGTGAACAAATCCA AGCACCTCCAGTTTATCAGTGGAGTGAGCCCCACCACCTACTGGGTGACCAACTTCCTCTGGGACATCATGAATTATTCCGTGAGTGCTG GGCTGGTGGTGGGCATCTTCATCGGGTTTCAGAAGAAAGCCTACACTTCTCCAGAAAACCTTCCTGCCCTTGTGGCACTGCTCCTGCTGT ATGGATGGGCGGTCATTCCCATGATGTACCCAGCATCCTTCCTGTTTGATGTCCCCAGCACAGCCTATGTGGCTTTATCTTGTGCTAATC TGTTCATCGGCATCAACAGCAGTGCTATTACCTTCATCTTGGAATTATTTGAGAATAACCGGACGCTGCTCAGGTTCAACGCCGTGCTGA GGAAGCTGCTCATTGTCTTCCCCCACTTCTGCCTGGGCCGGGGCCTCATTGACCTTGCACTGAGCCAGGCTGTGACAGATGTCTATGCCC GGTTTGGTGAGGAGCACTCTGCAAATCCGTTCCACTGGGACCTGATTGGGAAGAACCTGTTTGCCATGGTGGTGGAAGGGGTGGTGTACT TCCTCCTGACCCTGCTGGTCCAGCGCCACTTCTTCCTCTCCCAATGGATTGCCGAGCCCACTAAGGAGCCCATTGTTGATGAAGATGATG ATGTGGCTGAAGAAAGACAAAGAATTATTACTGGTGGAAATAAAACTGACATCTTAAGGCTACATGAACTAACCAAGATTTATCCAGGCA CCTCCAGCCCAGCAGTGGACAGGCTGTGTGTCGGAGTTCGCCCTGGAGAGTGCTTTGGCCTCCTGGGAGTGAATGGTGCCGGCAAAACAA CCACATTCAAGATGCTCACTGGGGACACCACAGTGACCTCAGGGGATGCCACCGTAGCAGGCAAGAGTATTTTAACCAATATTTCTGAAG TCCATCAAAATATGGGCTACTGTCCTCAGTTTGATGCAATTGATGAGCTGCTCACAGGACGAGAACATCTTTACCTTTATGCCCGGCTTC GAGGTGTACCAGCAGAAGAAATCGAAAAGGTTGCAAACTGGAGTATTAAGAGCCTGGGCCTGACTGTCTACGCCGACTGCCTGGCTGGCA CGTACAGTGGGGGCAACAAGCGGAAACTCTCCACAGCCATCGCACTCATTGGCTGCCCACCGCTGGTGCTGCTGGATGAGCCCACCACAG GGATGGACCCCCAGGCACGCCGCATGCTGTGGAACGTCATCGTGAGCATCATCAGAGAAGGGAGGGCTGTGGTCCTCACATCCCACAGCA TGGAAGAATGTGAGGCACTGTGTACCCGGCTGGCCATCATGGTAAAGGGCGCCTTTCGATGTATGGGCACCATTCAGCATCTCAAGTCCA AATTTGGAGATGGCTATATCGTCACAATGAAGATCAAATCCCCGAAGGACGACCTGCTTCCTGACCTGAACCCTGTGGAGCAGTTCTTCC AGGGGAACTTCCCAGGCAGTGTGCAGAGGGAGAGGCACTACAACATGCTCCAGTTCCAGGTCTCCTCCTCCTCCCTGGCGAGGATCTTCC AGCTCCTCCTCTCCCACAAGGACAGCCTGCTCATCGAGGAGTACTCAGTCACACAGACCACACTGGACCAGGTGTTTGTAAATTTTGCTA AACAGCAGACTGAAAGTCATGACCTCCCTCTGCACCCTCGAGCTGCTGGAGCCAGTCGACAAGCCCAGGACTGATCTTTCACACCGCTCG TTCCTGCAGCCAGAAAGGAACTCTGGGCAGCTGGAGGCGCAGGAGCCTGTGCCCATATGGTCATCCAAATGGACTGGCCAGCGTAAATGA CCCCACTGCAGCAGAAAACAAACACACGAGGAGCATGCAGCGAATTCAGAAAGAGGTCTTTCAGAAGGAAACCGAAACTGACTTGCTCAC CTGGAACACCTGATGGTGAAACCAAACAAATACAAAATCCTTCTCCAGACCCCAGAACTAGAAACCCCGGGCCATCCCACTAGCAGCTTT GGCCTCCATATTGCTCTCATTTCAAGCAGATCTGCTTTTCTGCATGTTTGTCTGTGTGTCTGCGTTGTGTGTGATTTTCATGGAAAAATA >9162_9162_3_BCAR3-ABCA4_BCAR3_chr1_94054534_ENST00000370243_ABCA4_chr1_94495187_ENST00000370225_length(amino acids)=1201AA_BP=378 MLGGTRAASSRALASPDPLPVGAALPATPPCPARPLFAEAGRGRADARAQSALVEAQGSEEASFSELRIMAAGKFASLPRNMPVNHQFPL ASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPPIRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLL DPTVEYVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKI NRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSL TMGGVQAREQNLPRGNLLREYPCGNSTPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLPECPEGAGGLPPPQRTQRSTEIL QDLTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPVVPITGEALVGFLSDLGRIMNVSGGPITREASKEIPDFLKHLETE DNIKVWFNNKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVVAICVIFSMSFVPASFVLYLI QERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPSTAY VALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGEEHSANPFHWDLIGKNLFAM VVEGVVYFLLTLLVQRHFFLSQWIAEPTKEPIVDEDDDVAEERQRIITGGNKTDILRLHELTKIYPGTSSPAVDRLCVGVRPGECFGLLG VNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTV YADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMG TIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSLARIFQLLLSHKDSLLIEEYSVTQTTLD -------------------------------------------------------------- >9162_9162_4_BCAR3-ABCA4_BCAR3_chr1_94054534_ENST00000370247_ABCA4_chr1_94495187_ENST00000370225_length(transcript)=3693nt_BP=823nt AGACTAGCCTGGGAGAAGGAGCCGACTCACTCCCCCGGCTGCCGACTTCCCTGACTTCTGGGCAGAAACAGCACAGCTGCTGTGGTGGGC TAGGGCTTTAACGTCCGAAGCCCCCTTTCTTTTAACCCTAAAGAAAGTGTGTGGTCCCCGGGACTGAAGACCGAAAGATGCCTAAGGAAT GCAGTGCTTTCCACGCCCTCTCAGCAGCTCTGTGCTGCTTCTATCACCGCAAGTCTTTCATTGGAGTCAAGTTCTCCAAGGAGAGGCACA TCATGGACAGGACCCCCGAGAAACTGAAGAAGGAGCTGGAGGAGGAGCTGCTCCTGAGCAGCGAGGACCTGCGCAGCCATGCCTGGTACC ACGGCCGCATCCCCCGACAGGTGTCTGAAAACCTTGTGCAGCGAGATGGTGACTTCCTAGTTCGTGACTCTCTGTCCAGCCCTGGGAACT TTGTCCTGACCTGTCAGTGGAAGAACCTCGCTCAGCACTTCAAAATCAACCGGACAGTTCTGCGACTCAGCGAGGCCTACAGCCGCGTGC AGTACCAGTTCGAGATGGAGAGCTTCGACTCCATCCCCGGCCTGGTGCGCTGCTACGTGGGCAACCGCCGGCCCATCTCCCAGCAGAGTG GCGCCATCATCTTCCAGCCCATCAACAGGACGGTGCCTCTGCGGTGCCTGGAGGAGCATTATGGCACCTCCCCAGGCCAGGCCCGGGAGG GCAGCCTCACCAAGGGAAGGCCGGATGTGGCCAAGAGGCTGAGCCTCACCATGGGTGGCGTCCAGGCCCGAGAGCAGAATTTGCCCAGGG GAAACCTCCTCAGGGAGTACCCCTGTGGCAACTCAACACCCTGGAAGACTCCTTCTGTGTCCCCAAACATCACCCAGCTGTTCCAGAAGC AGAAATGGACACAGGTCAACCCTTCACCATCCTGCAGGTGCAGCACCAGGGAGAAGCTCACCATGCTGCCAGAGTGCCCCGAGGGTGCCG GGGGCCTCCCGCCCCCCCAGAGAACACAGCGCAGCACGGAAATTCTACAAGACCTGACGGACAGGAACATCTCCGACTTCTTGGTAAAAA CGTATCCTGCTCTTATAAGAAGCAGCTTAAAGAGCAAATTCTGGGTCAATGAACAGAGGTATGGAGGAATTTCCATTGGAGGAAAGCTCC CAGTCGTCCCCATCACGGGGGAAGCACTTGTTGGGTTTTTAAGCGACCTTGGCCGGATCATGAATGTGAGCGGGGGCCCTATCACTAGAG AGGCCTCTAAAGAAATACCTGATTTCCTTAAACATCTAGAAACTGAAGACAACATTAAGGTGTGGTTTAATAACAAAGGCTGGCATGCCC TGGTCAGCTTTCTCAATGTGGCCCACAACGCCATCTTACGGGCCAGCCTGCCTAAGGACAGGAGCCCCGAGGAGTATGGAATCACCGTCA TTAGCCAACCCCTGAACCTGACCAAGGAGCAGCTCTCAGAGATTACAGTGCTGACCACTTCAGTGGATGCTGTGGTTGCCATCTGCGTGA TTTTCTCCATGTCCTTCGTCCCAGCCAGCTTTGTCCTTTATTTGATCCAGGAGCGGGTGAACAAATCCAAGCACCTCCAGTTTATCAGTG GAGTGAGCCCCACCACCTACTGGGTGACCAACTTCCTCTGGGACATCATGAATTATTCCGTGAGTGCTGGGCTGGTGGTGGGCATCTTCA TCGGGTTTCAGAAGAAAGCCTACACTTCTCCAGAAAACCTTCCTGCCCTTGTGGCACTGCTCCTGCTGTATGGATGGGCGGTCATTCCCA TGATGTACCCAGCATCCTTCCTGTTTGATGTCCCCAGCACAGCCTATGTGGCTTTATCTTGTGCTAATCTGTTCATCGGCATCAACAGCA GTGCTATTACCTTCATCTTGGAATTATTTGAGAATAACCGGACGCTGCTCAGGTTCAACGCCGTGCTGAGGAAGCTGCTCATTGTCTTCC CCCACTTCTGCCTGGGCCGGGGCCTCATTGACCTTGCACTGAGCCAGGCTGTGACAGATGTCTATGCCCGGTTTGGTGAGGAGCACTCTG CAAATCCGTTCCACTGGGACCTGATTGGGAAGAACCTGTTTGCCATGGTGGTGGAAGGGGTGGTGTACTTCCTCCTGACCCTGCTGGTCC AGCGCCACTTCTTCCTCTCCCAATGGATTGCCGAGCCCACTAAGGAGCCCATTGTTGATGAAGATGATGATGTGGCTGAAGAAAGACAAA GAATTATTACTGGTGGAAATAAAACTGACATCTTAAGGCTACATGAACTAACCAAGATTTATCCAGGCACCTCCAGCCCAGCAGTGGACA GGCTGTGTGTCGGAGTTCGCCCTGGAGAGTGCTTTGGCCTCCTGGGAGTGAATGGTGCCGGCAAAACAACCACATTCAAGATGCTCACTG GGGACACCACAGTGACCTCAGGGGATGCCACCGTAGCAGGCAAGAGTATTTTAACCAATATTTCTGAAGTCCATCAAAATATGGGCTACT GTCCTCAGTTTGATGCAATTGATGAGCTGCTCACAGGACGAGAACATCTTTACCTTTATGCCCGGCTTCGAGGTGTACCAGCAGAAGAAA TCGAAAAGGTTGCAAACTGGAGTATTAAGAGCCTGGGCCTGACTGTCTACGCCGACTGCCTGGCTGGCACGTACAGTGGGGGCAACAAGC GGAAACTCTCCACAGCCATCGCACTCATTGGCTGCCCACCGCTGGTGCTGCTGGATGAGCCCACCACAGGGATGGACCCCCAGGCACGCC GCATGCTGTGGAACGTCATCGTGAGCATCATCAGAGAAGGGAGGGCTGTGGTCCTCACATCCCACAGCATGGAAGAATGTGAGGCACTGT GTACCCGGCTGGCCATCATGGTAAAGGGCGCCTTTCGATGTATGGGCACCATTCAGCATCTCAAGTCCAAATTTGGAGATGGCTATATCG TCACAATGAAGATCAAATCCCCGAAGGACGACCTGCTTCCTGACCTGAACCCTGTGGAGCAGTTCTTCCAGGGGAACTTCCCAGGCAGTG TGCAGAGGGAGAGGCACTACAACATGCTCCAGTTCCAGGTCTCCTCCTCCTCCCTGGCGAGGATCTTCCAGCTCCTCCTCTCCCACAAGG ACAGCCTGCTCATCGAGGAGTACTCAGTCACACAGACCACACTGGACCAGGTGTTTGTAAATTTTGCTAAACAGCAGACTGAAAGTCATG ACCTCCCTCTGCACCCTCGAGCTGCTGGAGCCAGTCGACAAGCCCAGGACTGATCTTTCACACCGCTCGTTCCTGCAGCCAGAAAGGAAC TCTGGGCAGCTGGAGGCGCAGGAGCCTGTGCCCATATGGTCATCCAAATGGACTGGCCAGCGTAAATGACCCCACTGCAGCAGAAAACAA ACACACGAGGAGCATGCAGCGAATTCAGAAAGAGGTCTTTCAGAAGGAAACCGAAACTGACTTGCTCACCTGGAACACCTGATGGTGAAA CCAAACAAATACAAAATCCTTCTCCAGACCCCAGAACTAGAAACCCCGGGCCATCCCACTAGCAGCTTTGGCCTCCATATTGCTCTCATT TCAAGCAGATCTGCTTTTCTGCATGTTTGTCTGTGTGTCTGCGTTGTGTGTGATTTTCATGGAAAAATAAAATGCAAATGCACTCATCAC >9162_9162_4_BCAR3-ABCA4_BCAR3_chr1_94054534_ENST00000370247_ABCA4_chr1_94495187_ENST00000370225_length(amino acids)=1041AA_BP=218 MPKECSAFHALSAALCCFYHRKSFIGVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLS SPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEEHYGTSPG QAREGSLTKGRPDVAKRLSLTMGGVQAREQNLPRGNLLREYPCGNSTPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLPEC PEGAGGLPPPQRTQRSTEILQDLTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPVVPITGEALVGFLSDLGRIMNVSGG PITREASKEIPDFLKHLETEDNIKVWFNNKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVV AICVIFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGW AVIPMMYPASFLFDVPSTAYVALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFG EEHSANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRHFFLSQWIAEPTKEPIVDEDDDVAEERQRIITGGNKTDILRLHELTKIYPGTSS PAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGV PAEEIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEE CEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSLARIFQLL -------------------------------------------------------------- >9162_9162_5_BCAR3-ABCA4_BCAR3_chr1_94079404_ENST00000370247_ABCA4_chr1_94505683_ENST00000370225_length(transcript)=3951nt_BP=251nt AGACTAGCCTGGGAGAAGGAGCCGACTCACTCCCCCGGCTGCCGACTTCCCTGACTTCTGGGCAGAAACAGCACAGCTGCTGTGGTGGGC TAGGGCTTTAACGTCCGAAGCCCCCTTTCTTTTAACCCTAAAGAAAGTGTGTGGTCCCCGGGACTGAAGACCGAAAGATGCCTAAGGAAT GCAGTGCTTTCCACGCCCTCTCAGCAGCTCTGTGCTGCTTCTATCACCGCAAGTCTTTCATTGGAGTCAAGGGGACCTGCAGCTGCTCGT CTAAGGGTTTCTCCACCACGTGTCCAGCCCACGTCGATGACCTAACTCCAGAACAAGTCCTGGATGGGGATGTAAATGAGCTGATGGATG TAGTTCTCCACCATGTTCCAGAGGCAAAGCTGGTGGAGTGCATTGGTCAAGAACTTATCTTCCTTCTTCCAAATAAGAACTTCAAGCACA GAGCATATGCCAGCCTTTTCAGAGAGCTGGAGGAGACGCTGGCTGACCTTGGTCTCAGCAGTTTTGGAATTTCTGACACTCCCCTGGAAG AGATTTTTCTGAAGGTCACGGAGGATTCTGATTCAGGACCTCTGTTTGCGGGTGGCGCTCAGCAGAAAAGAGAAAACGTCAACCCCCGAC ACCCCTGCTTGGGTCCCAGAGAGAAGGCTGGACAGACACCCCAGGACTCCAATGTCTGCTCCCCAGGGGCGCCGGCTGCTCACCCAGAGG GCCAGCCTCCCCCAGAGCCAGAGTGCCCAGGCCCGCAGCTCAACACGGGGACACAGCTGGTCCTCCAGCATGTGCAGGCGCTGCTGGTCA AGAGATTCCAACACACCATCCGCAGCCACAAGGACTTCCTGGCGCAGATCGTGCTCCCGGCTACCTTTGTGTTTTTGGCTCTGATGCTTT CTATTGTTATCCCTCCTTTTGGCGAATACCCCGCTTTGACCCTTCACCCCTGGATATATGGGCAGCAGTACACCTTCTTCAGCATGGATG AACCAGGCAGTGAGCAGTTCACGGTACTTGCAGACGTCCTCCTGAATAAGCCAGGCTTTGGCAACCGCTGCCTGAAGGAAGGGTGGCTTC CGGAGTACCCCTGTGGCAACTCAACACCCTGGAAGACTCCTTCTGTGTCCCCAAACATCACCCAGCTGTTCCAGAAGCAGAAATGGACAC AGGTCAACCCTTCACCATCCTGCAGGTGCAGCACCAGGGAGAAGCTCACCATGCTGCCAGAGTGCCCCGAGGGTGCCGGGGGCCTCCCGC CCCCCCAGAGAACACAGCGCAGCACGGAAATTCTACAAGACCTGACGGACAGGAACATCTCCGACTTCTTGGTAAAAACGTATCCTGCTC TTATAAGAAGCAGCTTAAAGAGCAAATTCTGGGTCAATGAACAGAGGTATGGAGGAATTTCCATTGGAGGAAAGCTCCCAGTCGTCCCCA TCACGGGGGAAGCACTTGTTGGGTTTTTAAGCGACCTTGGCCGGATCATGAATGTGAGCGGGGGCCCTATCACTAGAGAGGCCTCTAAAG AAATACCTGATTTCCTTAAACATCTAGAAACTGAAGACAACATTAAGGTGTGGTTTAATAACAAAGGCTGGCATGCCCTGGTCAGCTTTC TCAATGTGGCCCACAACGCCATCTTACGGGCCAGCCTGCCTAAGGACAGGAGCCCCGAGGAGTATGGAATCACCGTCATTAGCCAACCCC TGAACCTGACCAAGGAGCAGCTCTCAGAGATTACAGTGCTGACCACTTCAGTGGATGCTGTGGTTGCCATCTGCGTGATTTTCTCCATGT CCTTCGTCCCAGCCAGCTTTGTCCTTTATTTGATCCAGGAGCGGGTGAACAAATCCAAGCACCTCCAGTTTATCAGTGGAGTGAGCCCCA CCACCTACTGGGTGACCAACTTCCTCTGGGACATCATGAATTATTCCGTGAGTGCTGGGCTGGTGGTGGGCATCTTCATCGGGTTTCAGA AGAAAGCCTACACTTCTCCAGAAAACCTTCCTGCCCTTGTGGCACTGCTCCTGCTGTATGGATGGGCGGTCATTCCCATGATGTACCCAG CATCCTTCCTGTTTGATGTCCCCAGCACAGCCTATGTGGCTTTATCTTGTGCTAATCTGTTCATCGGCATCAACAGCAGTGCTATTACCT TCATCTTGGAATTATTTGAGAATAACCGGACGCTGCTCAGGTTCAACGCCGTGCTGAGGAAGCTGCTCATTGTCTTCCCCCACTTCTGCC TGGGCCGGGGCCTCATTGACCTTGCACTGAGCCAGGCTGTGACAGATGTCTATGCCCGGTTTGGTGAGGAGCACTCTGCAAATCCGTTCC ACTGGGACCTGATTGGGAAGAACCTGTTTGCCATGGTGGTGGAAGGGGTGGTGTACTTCCTCCTGACCCTGCTGGTCCAGCGCCACTTCT TCCTCTCCCAATGGATTGCCGAGCCCACTAAGGAGCCCATTGTTGATGAAGATGATGATGTGGCTGAAGAAAGACAAAGAATTATTACTG GTGGAAATAAAACTGACATCTTAAGGCTACATGAACTAACCAAGATTTATCCAGGCACCTCCAGCCCAGCAGTGGACAGGCTGTGTGTCG GAGTTCGCCCTGGAGAGTGCTTTGGCCTCCTGGGAGTGAATGGTGCCGGCAAAACAACCACATTCAAGATGCTCACTGGGGACACCACAG TGACCTCAGGGGATGCCACCGTAGCAGGCAAGAGTATTTTAACCAATATTTCTGAAGTCCATCAAAATATGGGCTACTGTCCTCAGTTTG ATGCAATTGATGAGCTGCTCACAGGACGAGAACATCTTTACCTTTATGCCCGGCTTCGAGGTGTACCAGCAGAAGAAATCGAAAAGGTTG CAAACTGGAGTATTAAGAGCCTGGGCCTGACTGTCTACGCCGACTGCCTGGCTGGCACGTACAGTGGGGGCAACAAGCGGAAACTCTCCA CAGCCATCGCACTCATTGGCTGCCCACCGCTGGTGCTGCTGGATGAGCCCACCACAGGGATGGACCCCCAGGCACGCCGCATGCTGTGGA ACGTCATCGTGAGCATCATCAGAGAAGGGAGGGCTGTGGTCCTCACATCCCACAGCATGGAAGAATGTGAGGCACTGTGTACCCGGCTGG CCATCATGGTAAAGGGCGCCTTTCGATGTATGGGCACCATTCAGCATCTCAAGTCCAAATTTGGAGATGGCTATATCGTCACAATGAAGA TCAAATCCCCGAAGGACGACCTGCTTCCTGACCTGAACCCTGTGGAGCAGTTCTTCCAGGGGAACTTCCCAGGCAGTGTGCAGAGGGAGA GGCACTACAACATGCTCCAGTTCCAGGTCTCCTCCTCCTCCCTGGCGAGGATCTTCCAGCTCCTCCTCTCCCACAAGGACAGCCTGCTCA TCGAGGAGTACTCAGTCACACAGACCACACTGGACCAGGTGTTTGTAAATTTTGCTAAACAGCAGACTGAAAGTCATGACCTCCCTCTGC ACCCTCGAGCTGCTGGAGCCAGTCGACAAGCCCAGGACTGATCTTTCACACCGCTCGTTCCTGCAGCCAGAAAGGAACTCTGGGCAGCTG GAGGCGCAGGAGCCTGTGCCCATATGGTCATCCAAATGGACTGGCCAGCGTAAATGACCCCACTGCAGCAGAAAACAAACACACGAGGAG CATGCAGCGAATTCAGAAAGAGGTCTTTCAGAAGGAAACCGAAACTGACTTGCTCACCTGGAACACCTGATGGTGAAACCAAACAAATAC AAAATCCTTCTCCAGACCCCAGAACTAGAAACCCCGGGCCATCCCACTAGCAGCTTTGGCCTCCATATTGCTCTCATTTCAAGCAGATCT >9162_9162_5_BCAR3-ABCA4_BCAR3_chr1_94079404_ENST00000370247_ABCA4_chr1_94505683_ENST00000370225_length(amino acids)=1127AA_BP=28 MPKECSAFHALSAALCCFYHRKSFIGVKGTCSCSSKGFSTTCPAHVDDLTPEQVLDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNK NFKHRAYASLFRELEETLADLGLSSFGISDTPLEEIFLKVTEDSDSGPLFAGGAQQKRENVNPRHPCLGPREKAGQTPQDSNVCSPGAPA AHPEGQPPPEPECPGPQLNTGTQLVLQHVQALLVKRFQHTIRSHKDFLAQIVLPATFVFLALMLSIVIPPFGEYPALTLHPWIYGQQYTF FSMDEPGSEQFTVLADVLLNKPGFGNRCLKEGWLPEYPCGNSTPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLPECPEGA GGLPPPQRTQRSTEILQDLTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPVVPITGEALVGFLSDLGRIMNVSGGPITR EASKEIPDFLKHLETEDNIKVWFNNKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVVAICV IFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGWAVIP MMYPASFLFDVPSTAYVALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGEEHS ANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRHFFLSQWIAEPTKEPIVDEDDDVAEERQRIITGGNKTDILRLHELTKIYPGTSSPAVD RLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEE IEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEAL CTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSLARIFQLLLSHK -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for BCAR3-ABCA4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for BCAR3-ABCA4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for BCAR3-ABCA4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | BCAR3 | C0006142 | Malignant neoplasm of breast | 1 | CTD_human |
| Hgene | BCAR3 | C0013146 | Drug abuse | 1 | CTD_human |
| Hgene | BCAR3 | C0013170 | Drug habituation | 1 | CTD_human |
| Hgene | BCAR3 | C0013222 | Drug Use Disorders | 1 | CTD_human |
| Hgene | BCAR3 | C0029231 | Organic Mental Disorders, Substance-Induced | 1 | CTD_human |
| Hgene | BCAR3 | C0038580 | Substance Dependence | 1 | CTD_human |
| Hgene | BCAR3 | C0038586 | Substance Use Disorders | 1 | CTD_human |
| Hgene | BCAR3 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
| Hgene | BCAR3 | C0678222 | Breast Carcinoma | 1 | CTD_human |
| Hgene | BCAR3 | C0740858 | Substance abuse problem | 1 | CTD_human |
| Hgene | BCAR3 | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
| Hgene | BCAR3 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Hgene | BCAR3 | C1510472 | Drug Dependence | 1 | CTD_human |
| Hgene | BCAR3 | C4316881 | Prescription Drug Abuse | 1 | CTD_human |
| Hgene | BCAR3 | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |
| Tgene | C1855465 | STARGARDT DISEASE 1 (disorder) | 21 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
| Tgene | C1858806 | CONE-ROD DYSTROPHY 3 (disorder) | 3 | CTD_human;GENOMICS_ENGLAND;UNIPROT | |
| Tgene | C3489532 | Cone-Rod Dystrophy 2 | 3 | ORPHANET | |
| Tgene | C3495438 | Macular Degeneration, Age-Related, 2 | 2 | CTD_human;GENOMICS_ENGLAND;UNIPROT | |
| Tgene | C0008924 | Cleft upper lip | 1 | CTD_human | |
| Tgene | C0009402 | Colorectal Carcinoma | 1 | CTD_human | |
| Tgene | C0009404 | Colorectal Neoplasms | 1 | CTD_human | |
| Tgene | C0035334 | Retinitis Pigmentosa | 1 | CTD_human;GENOMICS_ENGLAND | |
| Tgene | C0242383 | Age related macular degeneration | 1 | CTD_human;GENOMICS_ENGLAND | |
| Tgene | C0271093 | Stargardt's disease | 1 | CTD_human;GENOMICS_ENGLAND;ORPHANET | |
| Tgene | C0339539 | Familial Exudative Vitreoretinopathy | 1 | CTD_human |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies