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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:BCAR3-TMED5 (FusionGDB2 ID:HG8412TG50999)

Fusion Gene Summary for BCAR3-TMED5

Fusion gene summary

Fusion gene information	Fusion gene name: BCAR3-TMED5
	Fusion gene ID: hg8412tg50999
		Hgene	Tgene
	Gene symbol	BCAR3	TMED5
	Gene ID	8412	50999
	Gene name	BCAR3 adaptor protein, NSP family member	transmembrane p24 trafficking protein 5
	Synonyms	AND-34\|NSP2\|SH2D3B	CGI-100\|p24g2\|p28
	Cytomap	('BCAR3')('TMED5') 1p22.1	1p22.1
	Type of gene	protein-coding	protein-coding
	Description	breast cancer anti-estrogen resistance protein 3BCAR3, NSP family adaptor proteinSH2 domain-containing protein 3Bbreast cancer anti-estrogen resistance 3breast cancer antiestrogen resistance 3 proteindJ1033H22.2 (breast cancer anti-estrogen resistanc	transmembrane emp24 domain-containing protein 5p24 family protein gamma-2p24gamma2transmembrane emp24 protein transport domain containing 5
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000260502, ENST00000370243, ENST00000370244, ENST00000370247, ENST00000466632, ENST00000539242,
Fusion gene scores	* DoF score	11 X 12 X 9=1188	5 X 3 X 3=45
	# samples	12	5
	** MAII score	log2(12/1188*10)=-3.30742852519225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/45*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: BCAR3 [Title/Abstract] AND TMED5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	BCAR3(94107859)-TMED5(93625783), # samples:1
Anticipated loss of major functional domain due to fusion event.	BCAR3-TMED5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BCAR3-TMED5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BCAR3-TMED5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across BCAR3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TMED5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-JY-A6FD	BCAR3	chr1	94107859	-	TMED5	chr1	93625783	-

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Fusion Gene ORF analysis for BCAR3-TMED5

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000260502	ENST00000370280	BCAR3	chr1	94107859	-	TMED5	chr1	93625783	-
5CDS-5UTR	ENST00000260502	ENST00000479918	BCAR3	chr1	94107859	-	TMED5	chr1	93625783	-
5CDS-5UTR	ENST00000260502	ENST00000483033	BCAR3	chr1	94107859	-	TMED5	chr1	93625783	-
5CDS-5UTR	ENST00000370243	ENST00000370280	BCAR3	chr1	94107859	-	TMED5	chr1	93625783	-
5CDS-5UTR	ENST00000370243	ENST00000479918	BCAR3	chr1	94107859	-	TMED5	chr1	93625783	-
5CDS-5UTR	ENST00000370243	ENST00000483033	BCAR3	chr1	94107859	-	TMED5	chr1	93625783	-
5CDS-5UTR	ENST00000370244	ENST00000370280	BCAR3	chr1	94107859	-	TMED5	chr1	93625783	-
5CDS-5UTR	ENST00000370244	ENST00000479918	BCAR3	chr1	94107859	-	TMED5	chr1	93625783	-
5CDS-5UTR	ENST00000370244	ENST00000483033	BCAR3	chr1	94107859	-	TMED5	chr1	93625783	-
Frame-shift	ENST00000260502	ENST00000370282	BCAR3	chr1	94107859	-	TMED5	chr1	93625783	-
Frame-shift	ENST00000370244	ENST00000370282	BCAR3	chr1	94107859	-	TMED5	chr1	93625783	-
In-frame	ENST00000370243	ENST00000370282	BCAR3	chr1	94107859	-	TMED5	chr1	93625783	-
intron-3CDS	ENST00000370247	ENST00000370282	BCAR3	chr1	94107859	-	TMED5	chr1	93625783	-
intron-3CDS	ENST00000466632	ENST00000370282	BCAR3	chr1	94107859	-	TMED5	chr1	93625783	-
intron-3CDS	ENST00000539242	ENST00000370282	BCAR3	chr1	94107859	-	TMED5	chr1	93625783	-
intron-5UTR	ENST00000370247	ENST00000370280	BCAR3	chr1	94107859	-	TMED5	chr1	93625783	-
intron-5UTR	ENST00000370247	ENST00000479918	BCAR3	chr1	94107859	-	TMED5	chr1	93625783	-
intron-5UTR	ENST00000370247	ENST00000483033	BCAR3	chr1	94107859	-	TMED5	chr1	93625783	-
intron-5UTR	ENST00000466632	ENST00000370280	BCAR3	chr1	94107859	-	TMED5	chr1	93625783	-
intron-5UTR	ENST00000466632	ENST00000479918	BCAR3	chr1	94107859	-	TMED5	chr1	93625783	-
intron-5UTR	ENST00000466632	ENST00000483033	BCAR3	chr1	94107859	-	TMED5	chr1	93625783	-
intron-5UTR	ENST00000539242	ENST00000370280	BCAR3	chr1	94107859	-	TMED5	chr1	93625783	-
intron-5UTR	ENST00000539242	ENST00000479918	BCAR3	chr1	94107859	-	TMED5	chr1	93625783	-
intron-5UTR	ENST00000539242	ENST00000483033	BCAR3	chr1	94107859	-	TMED5	chr1	93625783	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000370243

BCAR3

chr1

94107859

ENST00000370282

TMED5

chr1

93625783

6061

632

1132

354

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000370243	ENST00000370282	BCAR3	chr1	94107859	-	TMED5	chr1	93625783	-	0.00017586	0.9998242

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Fusion Genomic Features for BCAR3-TMED5

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

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Fusion Protein Features for BCAR3-TMED5

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:94107859/chr1:93625783)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TMED5

chr1:94107859

chr1:93625783

ENST00000370282

218_229

230.0

Topological domain

Cytoplasmic

Tgene

TMED5

chr1:94107859

chr1:93625783

ENST00000479918

218_229

194.0

Topological domain

Cytoplasmic

Tgene

TMED5

chr1:94107859

chr1:93625783

ENST00000370282

197_217

230.0

Transmembrane

Helical

Tgene

TMED5

chr1:94107859

chr1:93625783

ENST00000479918

197_217

194.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BCAR3

chr1:94107859

chr1:93625783

ENST00000260502

479_482

119

826.0

Compositional bias

Note=Poly-Asp

Hgene

BCAR3

chr1:94107859

chr1:93625783

ENST00000370243

479_482

119

826.0

Compositional bias

Note=Poly-Asp

Hgene

BCAR3

chr1:94107859

chr1:93625783

ENST00000370244

479_482

119

826.0

Compositional bias

Note=Poly-Asp

Hgene

BCAR3

chr1:94107859

chr1:93625783

ENST00000370247

479_482

735.0

Compositional bias

Note=Poly-Asp

Hgene

BCAR3

chr1:94107859

chr1:93625783

ENST00000539242

479_482

502.0

Compositional bias

Note=Poly-Asp

Hgene

BCAR3

chr1:94107859

chr1:93625783

ENST00000260502

154_253

119

826.0

Domain

SH2

Hgene

BCAR3

chr1:94107859

chr1:93625783

ENST00000260502

548_818

119

826.0

Domain

Ras-GEF

Hgene

BCAR3

chr1:94107859

chr1:93625783

ENST00000370243

154_253

119

826.0

Domain

SH2

Hgene

BCAR3

chr1:94107859

chr1:93625783

ENST00000370243

548_818

119

826.0

Domain

Ras-GEF

Hgene

BCAR3

chr1:94107859

chr1:93625783

ENST00000370244

154_253

119

826.0

Domain

SH2

Hgene

BCAR3

chr1:94107859

chr1:93625783

ENST00000370244

548_818

119

826.0

Domain

Ras-GEF

Hgene

BCAR3

chr1:94107859

chr1:93625783

ENST00000370247

154_253

735.0

Domain

SH2

Hgene

BCAR3

chr1:94107859

chr1:93625783

ENST00000370247

548_818

735.0

Domain

Ras-GEF

Hgene

BCAR3

chr1:94107859

chr1:93625783

ENST00000539242

154_253

502.0

Domain

SH2

Hgene

BCAR3

chr1:94107859

chr1:93625783

ENST00000539242

548_818

502.0

Domain

Ras-GEF

Tgene

TMED5

chr1:94107859

chr1:93625783

ENST00000370282

45_126

230.0

Domain

GOLD

Tgene

TMED5

chr1:94107859

chr1:93625783

ENST00000479918

45_126

194.0

Domain

GOLD

Tgene

TMED5

chr1:94107859

chr1:93625783

ENST00000370282

28_196

230.0

Topological domain

Lumenal

Tgene

TMED5

chr1:94107859

chr1:93625783

ENST00000479918

28_196

194.0

Topological domain

Lumenal

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Fusion Gene Sequence for BCAR3-TMED5

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>9173_9173_1_BCAR3-TMED5_BCAR3_chr1_94107859_ENST00000370243_TMED5_chr1_93625783_ENST00000370282_length(transcript)=6061nt_BP=632nt
GAGCGCGCTGGGACTCCCCGAGACGTGGCCCACGGCGGGGAGCGCTCAGCGATTGGCGGCCAGGCATCTTGCTCGGTGGCACTCGAGCGG
CATCTTCCCGGGCGCTGGCCTCGCCCGACCCCCTGCCCGTCGGAGCTGCTCTGCCGGCCACCCCGCCCTGTCCCGCCCGTCCCCTCTTCG
CAGAAGCCGGCCGGGGTCGGGCAGATGCGAGGGCCCAGAGCGCTCTGGTGGAAGCCCAAGGCTCCGAGGAGGCGAGTTTCTCCGAGTTGA
GAATTATGGCTGCAGGAAAATTTGCAAGCCTTCCCAGAAACATGCCGGTGAATCACCAGTTCCCCCTGGCCTCATCCATGGACCTTCTGA
GCAGCAGGTCCCCTCTCGCTGAGCATCGCCCAGATGCCTATCAAGATGTGTCTATACATGGCACCCTTCCACGGAAGAAAAAAGGTCCTC
CTCCCATAAGGTCCTGTGATGACTTCAGTCACATGGGCACCCTCCCCCACTCCAAATCCCCACGGCAGAACTCGCCTGTGACCCAGGATG
GCATCCAGGAGAGCCCATGGCAGGACCGGCACGGCGAAACCTTCACCTTCAGGGATCCACATCTTCTGGACCCAACTGTGGAATATGTGA
AGGTTTTAGATGGAGCAGGATTAGATATTGATTTCCATCTTGCCTCTCCAGAAGGCAAAACCTTAGTTTTTGAACAAAGAAAATCAGATG
GAGTTCACACTGTAGAGACTGAAGTTGGTGATTACATGTTCTGCTTTGACAATACATTCAGCACCATTTCTGAGAAGGTGATTTTCTTTG
AATTAATCCTGGATAATATGGGAGAACAGGCACAAGAACAAGAAGATTGGAAGAAATATATTACTGGCACAGATATATTGGATATGAAAC
TGGAAGACATCCTGGAATCCATCAACAGCATCAAGTCCAGACTAAGCAAAAGTGGGCACATACAAACTCTGCTTAGAGCATTTGAAGCTC
GTGATCGAAACATACAAGAAAGCAACTTTGATAGAGTCAATTTCTGGTCTATGGTTAATTTAGTGGTCATGGTGGTGGTGTCAGCCATTC
AAGTTTATATGCTGAAGAGTCTGTTTGAAGATAAGAGGAAAAGTAGAACTTAAAACTCCAAACTAGAGTACGTAACATTGAAAAATGAGG
CATAAAAATGCAATAAACTGTTACAGTCAAGACCATTAATGGTCTTCTCCAAAATATTTTGAGATATAAAAGTAGGAAACAGGTATAATT
TTAATGTGAAAATTAAGTCTTCACTTTCTGTGCAAGTAATCCTGCTGATCCAGTTGTACTTAAGTGTGTAACAGGAATATTTTGCAGAAT
ATAGGTTTAACTGAATGAAGCCATATTAATAACTGCATTTTCCTAACTTTGAAAAATTTTGCAAATGTCTTAGGTGATTTAAATAAATGA
GTATTGGGCCTAATTGCAACACCAGTCTGTTTTTAACAGGTTCTATTACCCAGAACTTTTTTGTAAATGCGGCAGTTACAAATTAACTGT
GGAAGTTTTCAGTTTTAAGTTATAAATCACCTGAGAATTACCTAATGATGGATTGAATAAATCTTTAGACTACAAAAGCCCAACTTTTCT
CTATTTACATATGCATCTCTCCTATAATGTAAATAGAATAATAGCTTTGAAATACAATTAGGTTTTTGAGATTTTTATAACCAAATACAT
TTCAGTGTAACATATTAGCAGAAAGCATTAGTCTTTGTACTTTGCTTACATTCCCAAAAGCTGACATTTTCACGATTCTTAAAAACACAA
AGTTACACTTACTAAAATTAGGACATGTTTTCTCTTTGAAATGAAGAATATAGTTTAAAAGCTTCCTCCTCCATAGGGACACATTTTCTC
TAACCCTTAACTAAAGTGTAGGATTTTAAAATTAAATGTGAGGTAAAATAAGTTTATTTTTAATAGTATCTGTCAAGTTAATATCTGTCA
ACAGTTAATAATCATGTTATGTTAATTTTAACATGATTGCTGACTTGGATAATTCATTATTACCAGCAGTTATGAAGGAAATATTGCTAA
AATGATCTGGGCCTACCATAAATAAATATCTCCTTTTCTGAGCTCTAAGAATTATCAGAAACAGGAAAGAATTTAGAAAAACTTGAGAAA
ACCTAATCCAAAATAAAATTCACTTAAGTAGAACTATAAATAAATATCTAGAATCTGACTGGCTCATCATGACATCCTACTCATAACATA
AATCAAAGGAGATGATTAATTTCCAGTTAGCTGGAAGAAACTTTGGCTGTAGGTTTTTATTTTCTACAAGAATTCTGGTTTGAATTATTT
TTGTAAGCAGGTACATTTTATAAAATGTAAGCCCTACTGTAAGGTTTAGCACTGGGTGTACATATTTATTAAAAATTTTTATTATAACAA
CTTTTATTAAAATGGCCTTTCTGAACACTTTATTTATTGATGTTGAAGTAAGGATTAGAAACATAGACTCCCAAGTTTTAAACACCTAAA
TGTGAATAACCCATATATACAACAAAGTTTCTGCCATCTAGCTTTTTGAAGTCTATGGGGGTCTTACTCAAGTACTAGTAATTTAACTTC
ATCATGAATGAACTATAATTTTTAAGTTATGCCCATTTATAACGTTGTTTATGACTACATTGTGAGTTAGAAACAAACTTAAAATTTGGG
GTATAGAACCCCTCAACAGGTTAGTAATGCTGGAATTCTTGATGAGCAATAATGATAACCAGAGAGTGATTTCATTTACACTCATAGTAG
TATAAAAAGAGATACATTTCCCTCTTAGGCCCCTGGGAGAAGAGCAGCTTAGATTTCCCTACTGGCAAGGTTTTTAAAAATGAGGTAAAT
GCCGTATATGATCAATTACCTTAATTGGCCAAGAAAATGCTTCAGGTGTCTAGGGGTATCCTCTGCAACACTTGCAGAACAAAGGTCAAT
AAGATCCTTGCCTATGAATACCCCTCCCTTTTGCGCTGTTAAATTTGCAATGAGAAGCAAATTTACAGTACCATAACTAATAAAGCAGGG
TACAGATATAAACTACTGCATCTTTTCTATAAAACTGTGATTAAGAATTCTACCTCTCCTGTATGGCTGTTACTGTACTGTACTCTCTGA
CTCCTTACCTAACAATGAATTTGTTACATAATCTTCTACATGTATGATTTGTGCCACTGATCTTAAACCTATGATTCAGTAACTTCTTAC
CATATAAAAACGATAATTGCTTTATTTGGAAAAGAATTTAGGAATACTAAGGACAATTATTTTTATAGACAAAGTAAAAAGACAGATATT
TAAGAGGCATAACCAAAAAAGCAAAACTTGTAAACAGAGTAAAAATCTTTAATATTTCTAAAGACATACTGTTTATCTGCTTCATATGCT
TTTTTTAATTTCACTATTCCATTTCTAAATTAAAGTTATGCTAAATTGAGTAAGCTGTTTATCACTTAACAGCTCATTTTGTCTTTTTCA
ATATACAAATTTTAAAAATACTACAATATTTAACTAAGGCCCAACCGATTTCCATAATGTAGCAGTTACCGTGTTCACCTCACACTAAGG
CCTAGAGTTTGCTCTGATATGCATTTGGATGATTAATGTTATGCTGTTCTTTCATGTGAATGTCAAGACATGGAGGGTGTTTGTAATTTT
ATGGTAAAATTAATCCTTCTTACACATAATGGTGTCTTAAAATTGACAAAAAATGAGCACTTACAATTGTATGTCTCCTCAAATGAAAAT
TCTTTATCTGAAATTTTAAAAGACATTGATTCCACATGTAAGGATTTTTCATCTGAAGTACAATAATGCACAATCAGTGTTGCTCAAACT
GCTTTATACTTATAAACAGCCATCTTAAATAAGCAACGTATTGTGAGTACTGATATGTATATAATAAAAATTATCAAAGAAAATTAACTG
CCAGTCATTTGTAAATGCTGTCTACTCCTGAAAGCCTTCCTTCATCTCTATTTAGTTAATAATGTGCTCTCTCCTCCTGTTTTGAAACCC
CATAGCTCTCTACACCTCTTATTGTACATCACTCTACTTTGCATTGGAGTTCTGTTTCTATATGTACTTATTCACCTGTTGCCTAAACAT
GCACTGTTCCTAAAAGGTACAGTTTTTGCTCAAAATATATGAAAGGAAAGATAATCAGTTCTTAAAGTTTGGTATGCTAAATAAGCACCC
AGGGAACTTACCTGCTCCACCTCACCCCAGAAATTGATTATTCAGGTCTGGAATATGGCTCAGGATTCTTAATTTTCAACCAACACAATA
TAGAATCCTGTCAGTTATCCTTGGATCATTTGCTAAGTGATCTTGCAAAATCAAAACTCCTTTGAGACTATTTCATTTTCAGAAATATTT
TAAAACTTGTTCAGAAACATCTTAAAACTTGTTAGCATATAGGAAAAGTACAATGCTTGGTGTAGGTAGGTTATTATTTGGTCATTTCCC
TCAAACCATCCAGACAAGCCACTCTTCTACCACAAGCTGGTAGAAATCCTTAGGCACCTTTCTGCTTCTGCACTGCTATCACTTTCAGGT
GTCTAAGGCTTCTGGAAGGCTGTTGTCATAACCTGGAGCCATACACCTAATGTACGTCTGGGGAAAGGACACCAATTAAAGAATCTAGAG
CTAGGATGATGTTACATAAGACAGGGCACAATGGAGATGGACTCTGGATCCCTGCATCTGAAAGAAAAAGGCAAGAAAATGCAGGGCAGG
GAAAATCCTGAAGGTCTTCACTGACCATGAATTAAAATCCTAATTGACAGTTTTACAAACAAAAACCCTCGTTTTAGTACTTGTGTTGTT
TTTGTTTCTGTTTTAACAAGCTTAGATTTATTATTGTGCCTTTTATGGAAGATGAGGAAGAAATAGGAAAGCAGTAAAATGAACAATGAG
AATCTGTTACCCAAACTGATATAAACTCCCTCAGAAAGAAAGATACTACTCCCTAATCCTGGAAGTGTTAAGTGGCAATAATGATCAAAT
GTTGTAAAGGGGATTGTTACTACAGCTAATATGAAATGGGAGGCTGGACTAAATCTAACCTTTCTACCCTTGATTTCAATTCTAAAAGGA
CACGTAATACCATTGCAGAAAGAAAAGACAGTTCCAAATGATAAATTTTAGAGTTGTTTTGCTAGGATGCAAGAGAAATTGGATAAGTGG
ACCACTCATACGTTGCTGGTGAGATATGAAATAGTAGAGCCACTGTGGAAAATATTCTTGGCAGTTTCTTATAAAACTAAACATACATTT
AACATATAACTGGCATTTGTACTACTTGACAGTTATCCCTGAGAAGTTAAAACTTAACATTCACAAATGTTACATAGCACCTTCATTTAT
AATAGCCAAAACCCGGAAACAACCTGGATGTCCTTCAAAAAGAGTGAATGGTTTAGTATGTCCACACCATGGAATACTAAATAGTAATAT
GAAGGAACAAACTACTGATACATGTAACAAATTGCATGGACCTCAAGGGAATTATGCTTGGGTGGTTTGGGGGGACAATCCTAAAGTTTT
ACACACTGTATGATTCTGTTTTTGTAACATTCTTAAATAATAAAGCTATAGAGATGGGAAACAAGATTCGTGGTTGCCAGGTCTTGGGAC
TGAAGGGAAGGAGAATGTGGCTATAAAGGGAGCCTTGTGGTGGAAAAGTTCTGTAGTTTGATTGTGGTGATTACATAAATATACATGTGA
AATGTTAGAAGTATTTATAGCTGAAACATATTAGTATGTTGGTATATACATATTTCTGACTAATTAATTTCGCCATGTTGCCCAGGCTGG
TCTCGAACTCCTAAGCTCAAGTGATGTGCCCGCCTCAACTTCCCAAGTGCTGAGATTACAGGCGTGAGCCACCATGTCCGGCCTGTTTTT
TCCTATGCATGCATAATTACGATCAAGTTTAATTTGTAATTAGGCACATTAAGAGATTAACAATAGCTAACAAAATGGAACAATTACAAC

>9173_9173_1_BCAR3-TMED5_BCAR3_chr1_94107859_ENST00000370243_TMED5_chr1_93625783_ENST00000370282_length(amino acids)=354AA_BP=1
MLGGTRAASSRALASPDPLPVGAALPATPPCPARPLFAEAGRGRADARAQSALVEAQGSEEASFSELRIMAAGKFASLPRNMPVNHQFPL
ASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPPIRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLL
DPTVEYVKVLDGAGLDIDFHLASPEGKTLVFEQRKSDGVHTVETEVGDYMFCFDNTFSTISEKVIFFELILDNMGEQAQEQEDWKKYITG

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Fusion Gene PPI Analysis for BCAR3-TMED5

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for BCAR3-TMED5

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for BCAR3-TMED5

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	BCAR3	C0006142	Malignant neoplasm of breast	1	CTD_human
Hgene	BCAR3	C0013146	Drug abuse	1	CTD_human
Hgene	BCAR3	C0013170	Drug habituation	1	CTD_human
Hgene	BCAR3	C0013222	Drug Use Disorders	1	CTD_human
Hgene	BCAR3	C0029231	Organic Mental Disorders, Substance-Induced	1	CTD_human
Hgene	BCAR3	C0038580	Substance Dependence	1	CTD_human
Hgene	BCAR3	C0038586	Substance Use Disorders	1	CTD_human
Hgene	BCAR3	C0236969	Substance-Related Disorders	1	CTD_human
Hgene	BCAR3	C0678222	Breast Carcinoma	1	CTD_human
Hgene	BCAR3	C0740858	Substance abuse problem	1	CTD_human
Hgene	BCAR3	C1257931	Mammary Neoplasms, Human	1	CTD_human
Hgene	BCAR3	C1458155	Mammary Neoplasms	1	CTD_human
Hgene	BCAR3	C1510472	Drug Dependence	1	CTD_human
Hgene	BCAR3	C4316881	Prescription Drug Abuse	1	CTD_human
Hgene	BCAR3	C4704874	Mammary Carcinoma, Human	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:BCAR3-TMED5 (FusionGDB2 ID:HG8412TG50999)

Fusion Gene Summary for BCAR3-TMED5

Fusion Gene ORF analysis for BCAR3-TMED5

Fusion Genomic Features for BCAR3-TMED5

Fusion Protein Features for BCAR3-TMED5

Fusion Gene Sequence for BCAR3-TMED5

Fusion Gene PPI Analysis for BCAR3-TMED5

Related Drugs for BCAR3-TMED5

Related Diseases for BCAR3-TMED5

Fusion Gene Studies
in Kim Lab