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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GARNL3-ITM2B (FusionGDB2 ID:HG84253TG9445)

Fusion Gene Summary for GARNL3-ITM2B

check button Fusion gene summary
Fusion gene informationFusion gene name: GARNL3-ITM2B
Fusion gene ID: hg84253tg9445
HgeneTgene
Gene symbol

GARNL3

ITM2B

Gene ID

84253

9445

Gene nameGTPase activating Rap/RanGAP domain like 3integral membrane protein 2B
SynonymsbA356B19.1ABRI|BRI|BRI2|BRICD2B|E25B|E3-16|FBD|RDGCA|imBRI2
Cytomap('GARNL3')('ITM2B')

9q33.3

13q14.2

Type of geneprotein-codingprotein-coding
DescriptionGTPase-activating Rap/Ran-GAP domain-like protein 3GTPase activating RANGAP domain-like 3integral membrane protein 2BABri/ADan amyloid peptideBRICHOS domain containing 2Bepididymis secretory sperm binding proteinimmature BRI2transmembrane protein BRI
Modification date2020031320200313
UniProtAcc

Q5VVW2

.
Ensembl transtripts involved in fusion geneENST00000314904, ENST00000373387, 
ENST00000435213, ENST00000496711, 
Fusion gene scores* DoF score4 X 4 X 3=4819 X 11 X 7=1463
# samples 422
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/1463*10)=-2.73335434061383
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GARNL3 [Title/Abstract] AND ITM2B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGARNL3(130107756)-ITM2B(48827944), # samples:1
Anticipated loss of major functional domain due to fusion event.GARNL3-ITM2B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GARNL3-ITM2B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GARNL3-ITM2B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GARNL3-ITM2B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneITM2B

GO:0042985

negative regulation of amyloid precursor protein biosynthetic process

16027166|18524908


check buttonFusion gene breakpoints across GARNL3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ITM2B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-IN-7808-01AGARNL3chr9

130107756

+ITM2Bchr13

48827944

+


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Fusion Gene ORF analysis for GARNL3-ITM2B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000314904ENST00000378549GARNL3chr9

130107756

+ITM2Bchr13

48827944

+
In-frameENST00000314904ENST00000378565GARNL3chr9

130107756

+ITM2Bchr13

48827944

+
In-frameENST00000373387ENST00000378549GARNL3chr9

130107756

+ITM2Bchr13

48827944

+
In-frameENST00000373387ENST00000378565GARNL3chr9

130107756

+ITM2Bchr13

48827944

+
In-frameENST00000435213ENST00000378549GARNL3chr9

130107756

+ITM2Bchr13

48827944

+
In-frameENST00000435213ENST00000378565GARNL3chr9

130107756

+ITM2Bchr13

48827944

+
intron-3CDSENST00000496711ENST00000378549GARNL3chr9

130107756

+ITM2Bchr13

48827944

+
intron-3CDSENST00000496711ENST00000378565GARNL3chr9

130107756

+ITM2Bchr13

48827944

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000435213GARNL3chr9130107756+ENST00000378565ITM2Bchr1348827944+347916953302378682
ENST00000435213GARNL3chr9130107756+ENST00000378549ITM2Bchr1348827944+222516953302060576
ENST00000314904GARNL3chr9130107756+ENST00000378565ITM2Bchr1348827944+361618323952515706
ENST00000314904GARNL3chr9130107756+ENST00000378549ITM2Bchr1348827944+236218323952197600
ENST00000373387GARNL3chr9130107756+ENST00000378565ITM2Bchr1348827944+356717833462466706
ENST00000373387GARNL3chr9130107756+ENST00000378549ITM2Bchr1348827944+231317833462148600

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000435213ENST00000378565GARNL3chr9130107756+ITM2Bchr1348827944+6.55E-050.99993455
ENST00000435213ENST00000378549GARNL3chr9130107756+ITM2Bchr1348827944+0.0002279810.999772
ENST00000314904ENST00000378565GARNL3chr9130107756+ITM2Bchr1348827944+0.0001384630.9998615
ENST00000314904ENST00000378549GARNL3chr9130107756+ITM2Bchr1348827944+0.0003136840.99968636
ENST00000373387ENST00000378565GARNL3chr9130107756+ITM2Bchr1348827944+0.0001419730.999858
ENST00000373387ENST00000378549GARNL3chr9130107756+ITM2Bchr1348827944+0.0003409080.99965906

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Fusion Genomic Features for GARNL3-ITM2B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GARNL3chr9130107756+ITM2Bchr1348827943+0.639154550.36084542
GARNL3chr9130107756+ITM2Bchr1348827943+0.639154550.36084542

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GARNL3-ITM2B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:130107756/chr13:48827944)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GARNL3

Q5VVW2

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGARNL3chr9:130107756chr13:48827944ENST00000314904+1627191_407477811.6666666666666DomainRap-GAP
HgeneGARNL3chr9:130107756chr13:48827944ENST00000373387+1628191_4074771014.0DomainRap-GAP
TgeneITM2Bchr9:130107756chr13:48827944ENST0000037856506137_23139267.0DomainBRICHOS
TgeneITM2Bchr9:130107756chr13:48827944ENST000003785650676_26639267.0Topological domainLumenal
TgeneITM2Bchr9:130107756chr13:48827944ENST000003785650655_7539267.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGARNL3chr9:130107756chr13:48827944ENST00000314904+1627489_800477811.6666666666666DomainCNH
HgeneGARNL3chr9:130107756chr13:48827944ENST00000373387+1628489_8004771014.0DomainCNH
TgeneITM2Bchr9:130107756chr13:48827944ENST00000378565061_5439267.0Topological domainCytoplasmic


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Fusion Gene Sequence for GARNL3-ITM2B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>32450_32450_1_GARNL3-ITM2B_GARNL3_chr9_130107756_ENST00000314904_ITM2B_chr13_48827944_ENST00000378549_length(transcript)=2362nt_BP=1832nt
CTCTTACTTAAAATATAGCATTAAATAATGCTGGTTATTTTTATGTTGCATATTTGGGACAAAGAGCTCTCTTAAATGAAAGATAATTGC
AAGATCCGGTTCAGCAGCTTTGTCCCTTGCCTCAAGTTTACTGCAGGGCTTCTCTCCTCTCTGGTTATACAGAAATGAAATTATAAACCA
CCAGTAACCTTGGAAATTTCAATCGATTCCAAATGACTAAATATTTAATTGAATCATTGCCTATACTTCCAGGGATGACTCTGGCGTTTG
CTTTTTATTGAGGGCTCCATGAAAGCCAGGCTCTGCAATGGCTGCTGGGGACTGTGTCTGTTGCAAGGAGGCTCCCCTGCAGTGAGGAGC
CGGGGCACTGCAAGTCTGTTCCATAGCAGCCCTTTTTGCAAATGGTAGTTGATTTTTGCAGAAGGTTTGTGGCCAGATCGCTATGTATAA
TACTGATGAAGCATTTTTGTTCCAGCTCTGTCTCGGAAGACCTAGGCTGTAGACGTGGGGATTTCAGTAGGAAACATTATGGATCTGTGG
AGCTGCTTATTTCCAGTGATGCTGATGGAGCCATCCAAAGGGCTGGAAGATTCAGAGTGGAAAATGGCTCTTCAGATGAGAATGCAACTG
CCCTGCCTGGTACTTGGCGAAGAACAGACGTGCACTTAGAGAACCCAGAATACCACACCAGATGGTATTTCAAATATTTTTTAGGACAAG
TCCATCAGAACTACATTGGAAACGATGCCGAGAAGAGCCCTTTCTTCTTGTCCGTGACCCTTTCTGACCAAAACAATCAACGTGTCCCTC
AATACCGTGCAATTCTTTGGAGAAAAACAGGTACCCAGAAAATATGCCTTCCCTACAGTCCCACAAAAACTCTTTCTGTGAAGTCCATCT
TAAGTGCCATGAATCTGGACAAATTTGAGAAAGGCCCCAGGGAAATTTTTCATCCTGAAATACAAAAGGACTTGCTGGTTCTTGAAGAAC
AAGAGGGCTCTGTGAATTTCAAGTTTGGGGTTCTTTTTGCCAAAGATGGGCAGCTCACTGATGATGAGATGTTCAGCAATGAAATTGGAA
GCGAGCCTTTTCAAAAATTTTTAAATCTTCTGGGTGACACAATCACTCTAAAGGGCTGGACGGGCTACCGTGGCGGTCTGGATACCAAAA
ATGATACCACAGGGATACATTCAGTTTATACTGTGTACCAAGGGCATGAGATCATGTTTCATGTTTCCACCATGTTGCCATATTCCAAAG
AGAACAAACAGCAGGTGGAAAGGAAACGCCACATTGGAAACGATATCGTCACCATTGTGTTCCAAGAAGGAGAGGAATCTTCTCCTGCCT
TTAAGCCTTCCATGATCCGCTCCCACTTTACACATATTTTTGCCTTAGTGAGATACAATCAACAAAATGACAATTACAGGCTGAAAATAT
TTTCAGAAGAGAGCGTACCACTCTTTGGCCCTCCCTTGCCAACTCCACCAGTGTTTACAGACCACCAGGAATTCAGGGACTTTTTGCTAG
TGAAATTAATTAATGGTGAAAAAGCCACTTTGGAAACCCCAACATTTGCCCAGAAACGTCGGCGTACCCTGGATATGTTGATTAGATCTT
TACACCAGGATTTGATGCCAGATTTGCATAAGAACATGCTTAATAGACGATCTTTTAGTGATGTCTTACCAGAGTCACCCAAGTCAGCGC
GGAAGAAAGAGGAGGCCCGCCAGGCGGAGTTTGTTAGAATAGGGCAGGCACTAAAACTGAAATCCATTGTGAGAGGGGATGCTCCATCAA
GCTTGGCAGCTTCAGGGATCTGTAAAAAAGAGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCT
TTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAAGCTGGAACCTATTTGCCTC
AGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATG
ACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTG
AAAACAAATTTGCCGTGGAAACTTTAATTTGTTCTTGAACAGTCAAGAAAAACATTATTGAGGAAAATTAATATCACAGCATAACCCCAC
CCTTTACATTTTGTGCAGTGATTATTTTTTAAAGTCTTCTTTCATGTAAGTAGCAAACAGGGCTTTACTATCTTTTCATCTCATTAATTC

>32450_32450_1_GARNL3-ITM2B_GARNL3_chr9_130107756_ENST00000314904_ITM2B_chr13_48827944_ENST00000378549_length(amino acids)=600AA_BP=479
MQMVVDFCRRFVARSLCIILMKHFCSSSVSEDLGCRRGDFSRKHYGSVELLISSDADGAIQRAGRFRVENGSSDENATALPGTWRRTDVH
LENPEYHTRWYFKYFLGQVHQNYIGNDAEKSPFFLSVTLSDQNNQRVPQYRAILWRKTGTQKICLPYSPTKTLSVKSILSAMNLDKFEKG
PREIFHPEIQKDLLVLEEQEGSVNFKFGVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLLGDTITLKGWTGYRGGLDTKNDTTGIHSVYTV
YQGHEIMFHVSTMLPYSKENKQQVERKRHIGNDIVTIVFQEGEESSPAFKPSMIRSHFTHIFALVRYNQQNDNYRLKIFSEESVPLFGPP
LPTPPVFTDHQEFRDFLLVKLINGEKATLETPTFAQKRRRTLDMLIRSLHQDLMPDLHKNMLNRRSFSDVLPESPKSARKKEEARQAEFV
RIGQALKLKSIVRGDAPSSLAASGICKKEDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQAGTYLPQSYLIHEHMVIT

--------------------------------------------------------------
>32450_32450_2_GARNL3-ITM2B_GARNL3_chr9_130107756_ENST00000314904_ITM2B_chr13_48827944_ENST00000378565_length(transcript)=3616nt_BP=1832nt
CTCTTACTTAAAATATAGCATTAAATAATGCTGGTTATTTTTATGTTGCATATTTGGGACAAAGAGCTCTCTTAAATGAAAGATAATTGC
AAGATCCGGTTCAGCAGCTTTGTCCCTTGCCTCAAGTTTACTGCAGGGCTTCTCTCCTCTCTGGTTATACAGAAATGAAATTATAAACCA
CCAGTAACCTTGGAAATTTCAATCGATTCCAAATGACTAAATATTTAATTGAATCATTGCCTATACTTCCAGGGATGACTCTGGCGTTTG
CTTTTTATTGAGGGCTCCATGAAAGCCAGGCTCTGCAATGGCTGCTGGGGACTGTGTCTGTTGCAAGGAGGCTCCCCTGCAGTGAGGAGC
CGGGGCACTGCAAGTCTGTTCCATAGCAGCCCTTTTTGCAAATGGTAGTTGATTTTTGCAGAAGGTTTGTGGCCAGATCGCTATGTATAA
TACTGATGAAGCATTTTTGTTCCAGCTCTGTCTCGGAAGACCTAGGCTGTAGACGTGGGGATTTCAGTAGGAAACATTATGGATCTGTGG
AGCTGCTTATTTCCAGTGATGCTGATGGAGCCATCCAAAGGGCTGGAAGATTCAGAGTGGAAAATGGCTCTTCAGATGAGAATGCAACTG
CCCTGCCTGGTACTTGGCGAAGAACAGACGTGCACTTAGAGAACCCAGAATACCACACCAGATGGTATTTCAAATATTTTTTAGGACAAG
TCCATCAGAACTACATTGGAAACGATGCCGAGAAGAGCCCTTTCTTCTTGTCCGTGACCCTTTCTGACCAAAACAATCAACGTGTCCCTC
AATACCGTGCAATTCTTTGGAGAAAAACAGGTACCCAGAAAATATGCCTTCCCTACAGTCCCACAAAAACTCTTTCTGTGAAGTCCATCT
TAAGTGCCATGAATCTGGACAAATTTGAGAAAGGCCCCAGGGAAATTTTTCATCCTGAAATACAAAAGGACTTGCTGGTTCTTGAAGAAC
AAGAGGGCTCTGTGAATTTCAAGTTTGGGGTTCTTTTTGCCAAAGATGGGCAGCTCACTGATGATGAGATGTTCAGCAATGAAATTGGAA
GCGAGCCTTTTCAAAAATTTTTAAATCTTCTGGGTGACACAATCACTCTAAAGGGCTGGACGGGCTACCGTGGCGGTCTGGATACCAAAA
ATGATACCACAGGGATACATTCAGTTTATACTGTGTACCAAGGGCATGAGATCATGTTTCATGTTTCCACCATGTTGCCATATTCCAAAG
AGAACAAACAGCAGGTGGAAAGGAAACGCCACATTGGAAACGATATCGTCACCATTGTGTTCCAAGAAGGAGAGGAATCTTCTCCTGCCT
TTAAGCCTTCCATGATCCGCTCCCACTTTACACATATTTTTGCCTTAGTGAGATACAATCAACAAAATGACAATTACAGGCTGAAAATAT
TTTCAGAAGAGAGCGTACCACTCTTTGGCCCTCCCTTGCCAACTCCACCAGTGTTTACAGACCACCAGGAATTCAGGGACTTTTTGCTAG
TGAAATTAATTAATGGTGAAAAAGCCACTTTGGAAACCCCAACATTTGCCCAGAAACGTCGGCGTACCCTGGATATGTTGATTAGATCTT
TACACCAGGATTTGATGCCAGATTTGCATAAGAACATGCTTAATAGACGATCTTTTAGTGATGTCTTACCAGAGTCACCCAAGTCAGCGC
GGAAGAAAGAGGAGGCCCGCCAGGCGGAGTTTGTTAGAATAGGGCAGGCACTAAAACTGAAATCCATTGTGAGAGGGGATGCTCCATCAA
GCTTGGCAGCTTCAGGGATCTGTAAAAAAGAGGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCT
TTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCACTTCAACCAGATGACGTGTACTACT
GTGGAATAAAGTACATCAAAGATGATGTCATCTTAAATGAGCCCTCTGCAGATGCCCCAGCTGCTCTCTACCAGACAATTGAAGAAAATA
TTAAAATCTTTGAAGAAGAAGAAGTTGAATTTATCAGTGTGCCTGTCCCAGAGTTTGCAGATAGTGATCCTGCCAACATTGTTCATGACT
TTAACAAGAAACTTACAGCCTATTTAGATCTTAACCTGGATAAGTGCTATGTGATCCCTCTGAACACTTCCATTGTTATGCCACCCAGAA
ACCTACTGGAGTTACTTATTAACATCAAGGCTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCA
TTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAG
GTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGAAAACAAATTTGCCGTGGAAACTTTAATTTGTTCTTGAACAG
TCAAGAAAAACATTATTGAGGAAAATTAATATCACAGCATAACCCCACCCTTTACATTTTGTGCAGTGATTATTTTTTAAAGTCTTCTTT
CATGTAAGTAGCAAACAGGGCTTTACTATCTTTTCATCTCATTAATTCAATTAAAACCATTACCTTAAAATTTTTTTCTTTCGAAGTGTG
GTGTCTTTTATATTTGAATTAGTAACTGTATGAAGTCATAGATAATAGTACATGTCACCTTAGGTAGTAGGAAGAATTACAATTTCTTTA
AATCATTTATCTGGATTTTTATGTTTTATTAGCATTTTCAAGAAGACGGATTATCTAGAGAATAATCATATATATGCATACGTAAAAATG
GACCACAGTGACTTATTTGTAGTTGTTAGTTGCCCTGCTACCTAGTTTGTTAGTGCATTTGAGCACACATTTTAATTTTCCTCTAATTAA
AATGTGCAGTATTTTCAGTGTCAAATATATTTAACTATTTAGAGAATGATTTCCACCTTTATGTTTTAATATCCTAGGCATCTGCTGTAA
TAATATTTTAGAAAATGTTTGGAATTTAAGAAATAACTTGTGTTACTAATTTGTATAACCCATATCTGTGCAATGGAATATAAATATCAC
AAAGTTGTTTAACTAGACTGCGTGTTGTTTTTCCCGTATAATAAAACCAAAGAATAGTTTGGTTCTTCAAATCTTAAGAGAATCCACATA
AAAGAAGAAACTATTTTTTAAAAATTCACTTCTATATATACAATGAGTAAAATCACAGATTTTTTCTTTAAATAAAAATAAGTCATTTTA
ATAACTAAACCAGATTCTTTGTGGATACTATTAAAGTAACATTTAAGCCTCAACCTTGAATGATGTTGTTTAATATAAAATGCTTTTATT
TTTGATGGAAAGGCAATCAAAGCCTAAAGTTTCCAAGGAACGTAAAATAACTGTGCTTCTCTGAGAATGCCCGCCTCACAAGTGGAACAT
TTTGAGTTAATAATGATGATTTTTATGTTTCTAAGGTTGCTTCCTCTCTGAAATAATTCAGAATCCACCCCCATTTAATAAAATACCTAT

>32450_32450_2_GARNL3-ITM2B_GARNL3_chr9_130107756_ENST00000314904_ITM2B_chr13_48827944_ENST00000378565_length(amino acids)=706AA_BP=479
MQMVVDFCRRFVARSLCIILMKHFCSSSVSEDLGCRRGDFSRKHYGSVELLISSDADGAIQRAGRFRVENGSSDENATALPGTWRRTDVH
LENPEYHTRWYFKYFLGQVHQNYIGNDAEKSPFFLSVTLSDQNNQRVPQYRAILWRKTGTQKICLPYSPTKTLSVKSILSAMNLDKFEKG
PREIFHPEIQKDLLVLEEQEGSVNFKFGVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLLGDTITLKGWTGYRGGLDTKNDTTGIHSVYTV
YQGHEIMFHVSTMLPYSKENKQQVERKRHIGNDIVTIVFQEGEESSPAFKPSMIRSHFTHIFALVRYNQQNDNYRLKIFSEESVPLFGPP
LPTPPVFTDHQEFRDFLLVKLINGEKATLETPTFAQKRRRTLDMLIRSLHQDLMPDLHKNMLNRRSFSDVLPESPKSARKKEEARQAEFV
RIGQALKLKSIVRGDAPSSLAASGICKKEDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVIL
NEPSADAPAALYQTIEENIKIFEEEEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAG

--------------------------------------------------------------
>32450_32450_3_GARNL3-ITM2B_GARNL3_chr9_130107756_ENST00000373387_ITM2B_chr13_48827944_ENST00000378549_length(transcript)=2313nt_BP=1783nt
ATATTTGGGACAAAGAGCTCTCTTAAATGAAAGATAATTGCAAGATCCGGTTCAGCAGCTTTGTCCCTTGCCTCAAGTTTACTGCAGGGC
TTCTCTCCTCTCTGGTTATACAGAAATGAAATTATAAACCACCAGTAACCTTGGAAATTTCAATCGATTCCAAATGACTAAATATTTAAT
TGAATCATTGCCTATACTTCCAGGGATGACTCTGGCGTTTGCTTTTTATTGAGGGCTCCATGAAAGCCAGGCTCTGCAATGGCTGCTGGG
GACTGTGTCTGTTGCAAGGAGGCTCCCCTGCAGTGAGGAGCCGGGGCACTGCAAGTCTGTTCCATAGCAGCCCTTTTTGCAAATGGTAGT
TGATTTTTGCAGAAGGTTTGTGGCCAGATCGCTATGTATAATACTGATGAAGCATTTTTGTTCCAGCTCTGTCTCGGAAGACCTAGGCTG
TAGACGTGGGGATTTCAGTAGGAAACATTATGGATCTGTGGAGCTGCTTATTTCCAGTGATGCTGATGGAGCCATCCAAAGGGCTGGAAG
ATTCAGAGTGGAAAATGGCTCTTCAGATGAGAATGCAACTGCCCTGCCTGGTACTTGGCGAAGAACAGACGTGCACTTAGAGAACCCAGA
ATACCACACCAGATGGTATTTCAAATATTTTTTAGGACAAGTCCATCAGAACTACATTGGAAACGATGCCGAGAAGAGCCCTTTCTTCTT
GTCCGTGACCCTTTCTGACCAAAACAATCAACGTGTCCCTCAATACCGTGCAATTCTTTGGAGAAAAACAGGTACCCAGAAAATATGCCT
TCCCTACAGTCCCACAAAAACTCTTTCTGTGAAGTCCATCTTAAGTGCCATGAATCTGGACAAATTTGAGAAAGGCCCCAGGGAAATTTT
TCATCCTGAAATACAAAAGGACTTGCTGGTTCTTGAAGAACAAGAGGGCTCTGTGAATTTCAAGTTTGGGGTTCTTTTTGCCAAAGATGG
GCAGCTCACTGATGATGAGATGTTCAGCAATGAAATTGGAAGCGAGCCTTTTCAAAAATTTTTAAATCTTCTGGGTGACACAATCACTCT
AAAGGGCTGGACGGGCTACCGTGGCGGTCTGGATACCAAAAATGATACCACAGGGATACATTCAGTTTATACTGTGTACCAAGGGCATGA
GATCATGTTTCATGTTTCCACCATGTTGCCATATTCCAAAGAGAACAAACAGCAGGTGGAAAGGAAACGCCACATTGGAAACGATATCGT
CACCATTGTGTTCCAAGAAGGAGAGGAATCTTCTCCTGCCTTTAAGCCTTCCATGATCCGCTCCCACTTTACACATATTTTTGCCTTAGT
GAGATACAATCAACAAAATGACAATTACAGGCTGAAAATATTTTCAGAAGAGAGCGTACCACTCTTTGGCCCTCCCTTGCCAACTCCACC
AGTGTTTACAGACCACCAGGAATTCAGGGACTTTTTGCTAGTGAAATTAATTAATGGTGAAAAAGCCACTTTGGAAACCCCAACATTTGC
CCAGAAACGTCGGCGTACCCTGGATATGTTGATTAGATCTTTACACCAGGATTTGATGCCAGATTTGCATAAGAACATGCTTAATAGACG
ATCTTTTAGTGATGTCTTACCAGAGTCACCCAAGTCAGCGCGGAAGAAAGAGGAGGCCCGCCAGGCGGAGTTTGTTAGAATAGGGCAGGC
ACTAAAACTGAAATCCATTGTGAGAGGGGATGCTCCATCAAGCTTGGCAGCTTCAGGGATCTGTAAAAAAGAGGACCCAGATGATGTGGT
ACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTT
GTACAAATATTTTGCACTTCAAGCTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAAAA
CATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCA
GAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGAAAACAAATTTGCCGTGGAAACTTTAATTTGTTCTTGAACAGTCAAGAA
AAACATTATTGAGGAAAATTAATATCACAGCATAACCCCACCCTTTACATTTTGTGCAGTGATTATTTTTTAAAGTCTTCTTTCATGTAA

>32450_32450_3_GARNL3-ITM2B_GARNL3_chr9_130107756_ENST00000373387_ITM2B_chr13_48827944_ENST00000378549_length(amino acids)=600AA_BP=479
MQMVVDFCRRFVARSLCIILMKHFCSSSVSEDLGCRRGDFSRKHYGSVELLISSDADGAIQRAGRFRVENGSSDENATALPGTWRRTDVH
LENPEYHTRWYFKYFLGQVHQNYIGNDAEKSPFFLSVTLSDQNNQRVPQYRAILWRKTGTQKICLPYSPTKTLSVKSILSAMNLDKFEKG
PREIFHPEIQKDLLVLEEQEGSVNFKFGVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLLGDTITLKGWTGYRGGLDTKNDTTGIHSVYTV
YQGHEIMFHVSTMLPYSKENKQQVERKRHIGNDIVTIVFQEGEESSPAFKPSMIRSHFTHIFALVRYNQQNDNYRLKIFSEESVPLFGPP
LPTPPVFTDHQEFRDFLLVKLINGEKATLETPTFAQKRRRTLDMLIRSLHQDLMPDLHKNMLNRRSFSDVLPESPKSARKKEEARQAEFV
RIGQALKLKSIVRGDAPSSLAASGICKKEDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQAGTYLPQSYLIHEHMVIT

--------------------------------------------------------------
>32450_32450_4_GARNL3-ITM2B_GARNL3_chr9_130107756_ENST00000373387_ITM2B_chr13_48827944_ENST00000378565_length(transcript)=3567nt_BP=1783nt
ATATTTGGGACAAAGAGCTCTCTTAAATGAAAGATAATTGCAAGATCCGGTTCAGCAGCTTTGTCCCTTGCCTCAAGTTTACTGCAGGGC
TTCTCTCCTCTCTGGTTATACAGAAATGAAATTATAAACCACCAGTAACCTTGGAAATTTCAATCGATTCCAAATGACTAAATATTTAAT
TGAATCATTGCCTATACTTCCAGGGATGACTCTGGCGTTTGCTTTTTATTGAGGGCTCCATGAAAGCCAGGCTCTGCAATGGCTGCTGGG
GACTGTGTCTGTTGCAAGGAGGCTCCCCTGCAGTGAGGAGCCGGGGCACTGCAAGTCTGTTCCATAGCAGCCCTTTTTGCAAATGGTAGT
TGATTTTTGCAGAAGGTTTGTGGCCAGATCGCTATGTATAATACTGATGAAGCATTTTTGTTCCAGCTCTGTCTCGGAAGACCTAGGCTG
TAGACGTGGGGATTTCAGTAGGAAACATTATGGATCTGTGGAGCTGCTTATTTCCAGTGATGCTGATGGAGCCATCCAAAGGGCTGGAAG
ATTCAGAGTGGAAAATGGCTCTTCAGATGAGAATGCAACTGCCCTGCCTGGTACTTGGCGAAGAACAGACGTGCACTTAGAGAACCCAGA
ATACCACACCAGATGGTATTTCAAATATTTTTTAGGACAAGTCCATCAGAACTACATTGGAAACGATGCCGAGAAGAGCCCTTTCTTCTT
GTCCGTGACCCTTTCTGACCAAAACAATCAACGTGTCCCTCAATACCGTGCAATTCTTTGGAGAAAAACAGGTACCCAGAAAATATGCCT
TCCCTACAGTCCCACAAAAACTCTTTCTGTGAAGTCCATCTTAAGTGCCATGAATCTGGACAAATTTGAGAAAGGCCCCAGGGAAATTTT
TCATCCTGAAATACAAAAGGACTTGCTGGTTCTTGAAGAACAAGAGGGCTCTGTGAATTTCAAGTTTGGGGTTCTTTTTGCCAAAGATGG
GCAGCTCACTGATGATGAGATGTTCAGCAATGAAATTGGAAGCGAGCCTTTTCAAAAATTTTTAAATCTTCTGGGTGACACAATCACTCT
AAAGGGCTGGACGGGCTACCGTGGCGGTCTGGATACCAAAAATGATACCACAGGGATACATTCAGTTTATACTGTGTACCAAGGGCATGA
GATCATGTTTCATGTTTCCACCATGTTGCCATATTCCAAAGAGAACAAACAGCAGGTGGAAAGGAAACGCCACATTGGAAACGATATCGT
CACCATTGTGTTCCAAGAAGGAGAGGAATCTTCTCCTGCCTTTAAGCCTTCCATGATCCGCTCCCACTTTACACATATTTTTGCCTTAGT
GAGATACAATCAACAAAATGACAATTACAGGCTGAAAATATTTTCAGAAGAGAGCGTACCACTCTTTGGCCCTCCCTTGCCAACTCCACC
AGTGTTTACAGACCACCAGGAATTCAGGGACTTTTTGCTAGTGAAATTAATTAATGGTGAAAAAGCCACTTTGGAAACCCCAACATTTGC
CCAGAAACGTCGGCGTACCCTGGATATGTTGATTAGATCTTTACACCAGGATTTGATGCCAGATTTGCATAAGAACATGCTTAATAGACG
ATCTTTTAGTGATGTCTTACCAGAGTCACCCAAGTCAGCGCGGAAGAAAGAGGAGGCCCGCCAGGCGGAGTTTGTTAGAATAGGGCAGGC
ACTAAAACTGAAATCCATTGTGAGAGGGGATGCTCCATCAAGCTTGGCAGCTTCAGGGATCTGTAAAAAAGAGGACCCAGATGATGTGGT
ACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTT
GTACAAATATTTTGCACTTCAACCAGATGACGTGTACTACTGTGGAATAAAGTACATCAAAGATGATGTCATCTTAAATGAGCCCTCTGC
AGATGCCCCAGCTGCTCTCTACCAGACAATTGAAGAAAATATTAAAATCTTTGAAGAAGAAGAAGTTGAATTTATCAGTGTGCCTGTCCC
AGAGTTTGCAGATAGTGATCCTGCCAACATTGTTCATGACTTTAACAAGAAACTTACAGCCTATTTAGATCTTAACCTGGATAAGTGCTA
TGTGATCCCTCTGAACACTTCCATTGTTATGCCACCCAGAAACCTACTGGAGTTACTTATTAACATCAAGGCTGGAACCTATTTGCCTCA
GTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGA
CAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGA
AAACAAATTTGCCGTGGAAACTTTAATTTGTTCTTGAACAGTCAAGAAAAACATTATTGAGGAAAATTAATATCACAGCATAACCCCACC
CTTTACATTTTGTGCAGTGATTATTTTTTAAAGTCTTCTTTCATGTAAGTAGCAAACAGGGCTTTACTATCTTTTCATCTCATTAATTCA
ATTAAAACCATTACCTTAAAATTTTTTTCTTTCGAAGTGTGGTGTCTTTTATATTTGAATTAGTAACTGTATGAAGTCATAGATAATAGT
ACATGTCACCTTAGGTAGTAGGAAGAATTACAATTTCTTTAAATCATTTATCTGGATTTTTATGTTTTATTAGCATTTTCAAGAAGACGG
ATTATCTAGAGAATAATCATATATATGCATACGTAAAAATGGACCACAGTGACTTATTTGTAGTTGTTAGTTGCCCTGCTACCTAGTTTG
TTAGTGCATTTGAGCACACATTTTAATTTTCCTCTAATTAAAATGTGCAGTATTTTCAGTGTCAAATATATTTAACTATTTAGAGAATGA
TTTCCACCTTTATGTTTTAATATCCTAGGCATCTGCTGTAATAATATTTTAGAAAATGTTTGGAATTTAAGAAATAACTTGTGTTACTAA
TTTGTATAACCCATATCTGTGCAATGGAATATAAATATCACAAAGTTGTTTAACTAGACTGCGTGTTGTTTTTCCCGTATAATAAAACCA
AAGAATAGTTTGGTTCTTCAAATCTTAAGAGAATCCACATAAAAGAAGAAACTATTTTTTAAAAATTCACTTCTATATATACAATGAGTA
AAATCACAGATTTTTTCTTTAAATAAAAATAAGTCATTTTAATAACTAAACCAGATTCTTTGTGGATACTATTAAAGTAACATTTAAGCC
TCAACCTTGAATGATGTTGTTTAATATAAAATGCTTTTATTTTTGATGGAAAGGCAATCAAAGCCTAAAGTTTCCAAGGAACGTAAAATA
ACTGTGCTTCTCTGAGAATGCCCGCCTCACAAGTGGAACATTTTGAGTTAATAATGATGATTTTTATGTTTCTAAGGTTGCTTCCTCTCT

>32450_32450_4_GARNL3-ITM2B_GARNL3_chr9_130107756_ENST00000373387_ITM2B_chr13_48827944_ENST00000378565_length(amino acids)=706AA_BP=479
MQMVVDFCRRFVARSLCIILMKHFCSSSVSEDLGCRRGDFSRKHYGSVELLISSDADGAIQRAGRFRVENGSSDENATALPGTWRRTDVH
LENPEYHTRWYFKYFLGQVHQNYIGNDAEKSPFFLSVTLSDQNNQRVPQYRAILWRKTGTQKICLPYSPTKTLSVKSILSAMNLDKFEKG
PREIFHPEIQKDLLVLEEQEGSVNFKFGVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLLGDTITLKGWTGYRGGLDTKNDTTGIHSVYTV
YQGHEIMFHVSTMLPYSKENKQQVERKRHIGNDIVTIVFQEGEESSPAFKPSMIRSHFTHIFALVRYNQQNDNYRLKIFSEESVPLFGPP
LPTPPVFTDHQEFRDFLLVKLINGEKATLETPTFAQKRRRTLDMLIRSLHQDLMPDLHKNMLNRRSFSDVLPESPKSARKKEEARQAEFV
RIGQALKLKSIVRGDAPSSLAASGICKKEDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVIL
NEPSADAPAALYQTIEENIKIFEEEEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAG

--------------------------------------------------------------
>32450_32450_5_GARNL3-ITM2B_GARNL3_chr9_130107756_ENST00000435213_ITM2B_chr13_48827944_ENST00000378549_length(transcript)=2225nt_BP=1695nt
ACTAGAAGCAAGAATGTAGCCTGGGTAATATCTGGAACACTTTCAAACTGCATGCATTGATGTGTTGCCCATTTTCAGCTAAGAGAGGGA
GGACTACAAAAGGTTAAATTTCTCATATAAGATTAATTCAGCCATCTCTGTGAAATGGTGGAAGCAGAATGCCATTAGACTCTCTAATCT
CATTTCTCTCATGCTGTCTTTCTTGGAGCCTGTCAAACAGTGTCCTGGCAGAGAGTCAGTTCTCTGGTTGCTAAACATCAGAGTCAGTCT
CTTTCTGCATGTGCCAAGAGGGCTGTAATTTAGAAAATGCAACCTACCTTTTAAGGAAGGATGAAAAGCTCTGTCTCGGAAGACCTAGGC
TGTAGACGTGGGGATTTCAGTAGGAAACATTATGGATCTGTGGAGCTGCTTATTTCCAGTGATGCTGATGGAGCCATCCAAAGGGCTGGA
AGATTCAGAGTGGAAAATGGCTCTTCAGATGAGAATGCAACTGCCCTGCCTGGTACTTGGCGAAGAACAGACGTGCACTTAGAGAACCCA
GAATACCACACCAGATGGTATTTCAAATATTTTTTAGGACAAGTCCATCAGAACTACATTGGAAACGATGCCGAGAAGAGCCCTTTCTTC
TTGTCCGTGACCCTTTCTGACCAAAACAATCAACGTGTCCCTCAATACCGTGCAATTCTTTGGAGAAAAACAGGTACCCAGAAAATATGC
CTTCCCTACAGTCCCACAAAAACTCTTTCTGTGAAGTCCATCTTAAGTGCCATGAATCTGGACAAATTTGAGAAAGGCCCCAGGGAAATT
TTTCATCCTGAAATACAAAAGGACTTGCTGGTTCTTGAAGAACAAGAGGGCTCTGTGAATTTCAAGTTTGGGGTTCTTTTTGCCAAAGAT
GGGCAGCTCACTGATGATGAGATGTTCAGCAATGAAATTGGAAGCGAGCCTTTTCAAAAATTTTTAAATCTTCTGGGTGACACAATCACT
CTAAAGGGCTGGACGGGCTACCGTGGCGGTCTGGATACCAAAAATGATACCACAGGGATACATTCAGTTTATACTGTGTACCAAGGGCAT
GAGATCATGTTTCATGTTTCCACCATGTTGCCATATTCCAAAGAGAACAAACAGCAGGTGGAAAGGAAACGCCACATTGGAAACGATATC
GTCACCATTGTGTTCCAAGAAGGAGAGGAATCTTCTCCTGCCTTTAAGCCTTCCATGATCCGCTCCCACTTTACACATATTTTTGCCTTA
GTGAGATACAATCAACAAAATGACAATTACAGGCTGAAAATATTTTCAGAAGAGAGCGTACCACTCTTTGGCCCTCCCTTGCCAACTCCA
CCAGTGTTTACAGACCACCAGGAATTCAGGGACTTTTTGCTAGTGAAATTAATTAATGGTGAAAAAGCCACTTTGGAAACCCCAACATTT
GCCCAGAAACGTCGGCGTACCCTGGATATGTTGATTAGATCTTTACACCAGGATTTGATGCCAGATTTGCATAAGAACATGCTTAATAGA
CGATCTTTTAGTGATGTCTTACCAGAGTCACCCAAGTCAGCGCGGAAGAAAGAGGAGGCCCGCCAGGCGGAGTTTGTTAGAATAGGGCAG
GCACTAAAACTGAAATCCATTGTGAGAGGGGATGCTCCATCAAGCTTGGCAGCTTCAGGGATCTGTAAAAAAGAGGACCCAGATGATGTG
GTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATAC
TTGTACAAATATTTTGCACTTCAAGCTGGAACCTATTTGCCTCAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAA
AACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATT
CAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGAAAACAAATTTGCCGTGGAAACTTTAATTTGTTCTTGAACAGTCAAG
AAAAACATTATTGAGGAAAATTAATATCACAGCATAACCCCACCCTTTACATTTTGTGCAGTGATTATTTTTTAAAGTCTTCTTTCATGT

>32450_32450_5_GARNL3-ITM2B_GARNL3_chr9_130107756_ENST00000435213_ITM2B_chr13_48827944_ENST00000378549_length(amino acids)=576AA_BP=455
MKSSVSEDLGCRRGDFSRKHYGSVELLISSDADGAIQRAGRFRVENGSSDENATALPGTWRRTDVHLENPEYHTRWYFKYFLGQVHQNYI
GNDAEKSPFFLSVTLSDQNNQRVPQYRAILWRKTGTQKICLPYSPTKTLSVKSILSAMNLDKFEKGPREIFHPEIQKDLLVLEEQEGSVN
FKFGVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLLGDTITLKGWTGYRGGLDTKNDTTGIHSVYTVYQGHEIMFHVSTMLPYSKENKQQV
ERKRHIGNDIVTIVFQEGEESSPAFKPSMIRSHFTHIFALVRYNQQNDNYRLKIFSEESVPLFGPPLPTPPVFTDHQEFRDFLLVKLING
EKATLETPTFAQKRRRTLDMLIRSLHQDLMPDLHKNMLNRRSFSDVLPESPKSARKKEEARQAEFVRIGQALKLKSIVRGDAPSSLAASG
ICKKEDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQAGTYLPQSYLIHEHMVITDRIENIDHLGFFIYRLCHDKETYK

--------------------------------------------------------------
>32450_32450_6_GARNL3-ITM2B_GARNL3_chr9_130107756_ENST00000435213_ITM2B_chr13_48827944_ENST00000378565_length(transcript)=3479nt_BP=1695nt
ACTAGAAGCAAGAATGTAGCCTGGGTAATATCTGGAACACTTTCAAACTGCATGCATTGATGTGTTGCCCATTTTCAGCTAAGAGAGGGA
GGACTACAAAAGGTTAAATTTCTCATATAAGATTAATTCAGCCATCTCTGTGAAATGGTGGAAGCAGAATGCCATTAGACTCTCTAATCT
CATTTCTCTCATGCTGTCTTTCTTGGAGCCTGTCAAACAGTGTCCTGGCAGAGAGTCAGTTCTCTGGTTGCTAAACATCAGAGTCAGTCT
CTTTCTGCATGTGCCAAGAGGGCTGTAATTTAGAAAATGCAACCTACCTTTTAAGGAAGGATGAAAAGCTCTGTCTCGGAAGACCTAGGC
TGTAGACGTGGGGATTTCAGTAGGAAACATTATGGATCTGTGGAGCTGCTTATTTCCAGTGATGCTGATGGAGCCATCCAAAGGGCTGGA
AGATTCAGAGTGGAAAATGGCTCTTCAGATGAGAATGCAACTGCCCTGCCTGGTACTTGGCGAAGAACAGACGTGCACTTAGAGAACCCA
GAATACCACACCAGATGGTATTTCAAATATTTTTTAGGACAAGTCCATCAGAACTACATTGGAAACGATGCCGAGAAGAGCCCTTTCTTC
TTGTCCGTGACCCTTTCTGACCAAAACAATCAACGTGTCCCTCAATACCGTGCAATTCTTTGGAGAAAAACAGGTACCCAGAAAATATGC
CTTCCCTACAGTCCCACAAAAACTCTTTCTGTGAAGTCCATCTTAAGTGCCATGAATCTGGACAAATTTGAGAAAGGCCCCAGGGAAATT
TTTCATCCTGAAATACAAAAGGACTTGCTGGTTCTTGAAGAACAAGAGGGCTCTGTGAATTTCAAGTTTGGGGTTCTTTTTGCCAAAGAT
GGGCAGCTCACTGATGATGAGATGTTCAGCAATGAAATTGGAAGCGAGCCTTTTCAAAAATTTTTAAATCTTCTGGGTGACACAATCACT
CTAAAGGGCTGGACGGGCTACCGTGGCGGTCTGGATACCAAAAATGATACCACAGGGATACATTCAGTTTATACTGTGTACCAAGGGCAT
GAGATCATGTTTCATGTTTCCACCATGTTGCCATATTCCAAAGAGAACAAACAGCAGGTGGAAAGGAAACGCCACATTGGAAACGATATC
GTCACCATTGTGTTCCAAGAAGGAGAGGAATCTTCTCCTGCCTTTAAGCCTTCCATGATCCGCTCCCACTTTACACATATTTTTGCCTTA
GTGAGATACAATCAACAAAATGACAATTACAGGCTGAAAATATTTTCAGAAGAGAGCGTACCACTCTTTGGCCCTCCCTTGCCAACTCCA
CCAGTGTTTACAGACCACCAGGAATTCAGGGACTTTTTGCTAGTGAAATTAATTAATGGTGAAAAAGCCACTTTGGAAACCCCAACATTT
GCCCAGAAACGTCGGCGTACCCTGGATATGTTGATTAGATCTTTACACCAGGATTTGATGCCAGATTTGCATAAGAACATGCTTAATAGA
CGATCTTTTAGTGATGTCTTACCAGAGTCACCCAAGTCAGCGCGGAAGAAAGAGGAGGCCCGCCAGGCGGAGTTTGTTAGAATAGGGCAG
GCACTAAAACTGAAATCCATTGTGAGAGGGGATGCTCCATCAAGCTTGGCAGCTTCAGGGATCTGTAAAAAAGAGGACCCAGATGATGTG
GTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTTGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATAC
TTGTACAAATATTTTGCACTTCAACCAGATGACGTGTACTACTGTGGAATAAAGTACATCAAAGATGATGTCATCTTAAATGAGCCCTCT
GCAGATGCCCCAGCTGCTCTCTACCAGACAATTGAAGAAAATATTAAAATCTTTGAAGAAGAAGAAGTTGAATTTATCAGTGTGCCTGTC
CCAGAGTTTGCAGATAGTGATCCTGCCAACATTGTTCATGACTTTAACAAGAAACTTACAGCCTATTTAGATCTTAACCTGGATAAGTGC
TATGTGATCCCTCTGAACACTTCCATTGTTATGCCACCCAGAAACCTACTGGAGTTACTTATTAACATCAAGGCTGGAACCTATTTGCCT
CAGTCCTATCTGATTCATGAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTATCGACTGTGTCAT
GACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATTCAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTT
GAAAACAAATTTGCCGTGGAAACTTTAATTTGTTCTTGAACAGTCAAGAAAAACATTATTGAGGAAAATTAATATCACAGCATAACCCCA
CCCTTTACATTTTGTGCAGTGATTATTTTTTAAAGTCTTCTTTCATGTAAGTAGCAAACAGGGCTTTACTATCTTTTCATCTCATTAATT
CAATTAAAACCATTACCTTAAAATTTTTTTCTTTCGAAGTGTGGTGTCTTTTATATTTGAATTAGTAACTGTATGAAGTCATAGATAATA
GTACATGTCACCTTAGGTAGTAGGAAGAATTACAATTTCTTTAAATCATTTATCTGGATTTTTATGTTTTATTAGCATTTTCAAGAAGAC
GGATTATCTAGAGAATAATCATATATATGCATACGTAAAAATGGACCACAGTGACTTATTTGTAGTTGTTAGTTGCCCTGCTACCTAGTT
TGTTAGTGCATTTGAGCACACATTTTAATTTTCCTCTAATTAAAATGTGCAGTATTTTCAGTGTCAAATATATTTAACTATTTAGAGAAT
GATTTCCACCTTTATGTTTTAATATCCTAGGCATCTGCTGTAATAATATTTTAGAAAATGTTTGGAATTTAAGAAATAACTTGTGTTACT
AATTTGTATAACCCATATCTGTGCAATGGAATATAAATATCACAAAGTTGTTTAACTAGACTGCGTGTTGTTTTTCCCGTATAATAAAAC
CAAAGAATAGTTTGGTTCTTCAAATCTTAAGAGAATCCACATAAAAGAAGAAACTATTTTTTAAAAATTCACTTCTATATATACAATGAG
TAAAATCACAGATTTTTTCTTTAAATAAAAATAAGTCATTTTAATAACTAAACCAGATTCTTTGTGGATACTATTAAAGTAACATTTAAG
CCTCAACCTTGAATGATGTTGTTTAATATAAAATGCTTTTATTTTTGATGGAAAGGCAATCAAAGCCTAAAGTTTCCAAGGAACGTAAAA
TAACTGTGCTTCTCTGAGAATGCCCGCCTCACAAGTGGAACATTTTGAGTTAATAATGATGATTTTTATGTTTCTAAGGTTGCTTCCTCT

>32450_32450_6_GARNL3-ITM2B_GARNL3_chr9_130107756_ENST00000435213_ITM2B_chr13_48827944_ENST00000378565_length(amino acids)=682AA_BP=455
MKSSVSEDLGCRRGDFSRKHYGSVELLISSDADGAIQRAGRFRVENGSSDENATALPGTWRRTDVHLENPEYHTRWYFKYFLGQVHQNYI
GNDAEKSPFFLSVTLSDQNNQRVPQYRAILWRKTGTQKICLPYSPTKTLSVKSILSAMNLDKFEKGPREIFHPEIQKDLLVLEEQEGSVN
FKFGVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLLGDTITLKGWTGYRGGLDTKNDTTGIHSVYTVYQGHEIMFHVSTMLPYSKENKQQV
ERKRHIGNDIVTIVFQEGEESSPAFKPSMIRSHFTHIFALVRYNQQNDNYRLKIFSEESVPLFGPPLPTPPVFTDHQEFRDFLLVKLING
EKATLETPTFAQKRRRTLDMLIRSLHQDLMPDLHKNMLNRRSFSDVLPESPKSARKKEEARQAEFVRIGQALKLKSIVRGDAPSSLAASG
ICKKEDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAALYQTIEENIKIFEE
EEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVITDRIENIDH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GARNL3-ITM2B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GARNL3-ITM2B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GARNL3-ITM2B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC1867773CEREBRAL AMYLOID ANGIOPATHY, ITM2B-RELATED, 12CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC0020538Hypertensive disease1CTD_human
TgeneC0038454Cerebrovascular accident1GENOMICS_ENGLAND
TgeneC0270790Quadriparesis1GENOMICS_ENGLAND
TgeneC0553692Brain hemorrhage1GENOMICS_ENGLAND
TgeneC0575059Spastic tetraparesis1GENOMICS_ENGLAND
TgeneC0948008Ischemic stroke1GENOMICS_ENGLAND
TgeneC1861735Dementia, familial Danish1CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC4015146RETINAL DYSTROPHY WITH INNER RETINAL DYSFUNCTION AND GANGLION CELL ABNORMALITIES1CTD_human;ORPHANET;UNIPROT