Fusion Gene Studies
in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EFCAB2-FKBP3 (FusionGDB2 ID:HG84288TG2287)

Fusion Gene Summary for EFCAB2-FKBP3

check button Fusion gene summary
Fusion gene informationFusion gene name: EFCAB2-FKBP3
Fusion gene ID: hg84288tg2287
HgeneTgene
Gene symbol

EFCAB2

FKBP3

Gene ID

84288

2287

Gene nameEF-hand calcium binding domain 2FKBP prolyl isomerase 3
SynonymsCFAP200|DRC8FKBP-25|FKBP-3|FKBP25|PPIase
Cytomap('EFCAB2')('FKBP3')

1q44

14q21.2

Type of geneprotein-codingprotein-coding
Descriptiondynein regulatory complex protein 8EF-hand calcium-binding domain-containing protein 2dynein regulatory complex subunit 8peptidyl-prolyl cis-trans isomerase FKBP325 kDa FK506-binding protein25 kDa FKBPFK506 binding protein 3, 25kDaFK506-binding protein 25, T-cellFK506-binding protein 3PPIase FKBP3immunophilin FKBP25rapamycin binding proteinrapamycin-selective 25 kD
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000487845, ENST00000366522, 
ENST00000366523, ENST00000447569, 
Fusion gene scores* DoF score4 X 4 X 3=489 X 7 X 4=252
# samples 510
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(10/252*10)=-1.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EFCAB2 [Title/Abstract] AND FKBP3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEFCAB2(245222760)-FKBP3(45600003), # samples:2
Anticipated loss of major functional domain due to fusion event.EFCAB2-FKBP3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EFCAB2-FKBP3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EFCAB2-FKBP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EFCAB2-FKBP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across EFCAB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across FKBP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-44-8117-01AEFCAB2chr1

245222760

+FKBP3chr14

45600003

-


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Fusion Gene ORF analysis for EFCAB2-FKBP3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000487845ENST00000216330EFCAB2chr1

245222760

+FKBP3chr14

45600003

-
3UTR-3CDSENST00000487845ENST00000396062EFCAB2chr1

245222760

+FKBP3chr14

45600003

-
In-frameENST00000366522ENST00000216330EFCAB2chr1

245222760

+FKBP3chr14

45600003

-
In-frameENST00000366522ENST00000396062EFCAB2chr1

245222760

+FKBP3chr14

45600003

-
In-frameENST00000366523ENST00000216330EFCAB2chr1

245222760

+FKBP3chr14

45600003

-
In-frameENST00000366523ENST00000396062EFCAB2chr1

245222760

+FKBP3chr14

45600003

-
In-frameENST00000447569ENST00000216330EFCAB2chr1

245222760

+FKBP3chr14

45600003

-
In-frameENST00000447569ENST00000396062EFCAB2chr1

245222760

+FKBP3chr14

45600003

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000366523EFCAB2chr1245222760+ENST00000396062FKBP3chr1445600003-16134482651014249
ENST00000366523EFCAB2chr1245222760+ENST00000216330FKBP3chr1445600003-16134482651014249
ENST00000366522EFCAB2chr1245222760+ENST00000396062FKBP3chr1445600003-18977321411298385
ENST00000366522EFCAB2chr1245222760+ENST00000216330FKBP3chr1445600003-18977321411298385
ENST00000447569EFCAB2chr1245222760+ENST00000396062FKBP3chr1445600003-144027592841249
ENST00000447569EFCAB2chr1245222760+ENST00000216330FKBP3chr1445600003-144027592841249

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000366523ENST00000396062EFCAB2chr1245222760+FKBP3chr1445600003-0.0016798660.99832016
ENST00000366523ENST00000216330EFCAB2chr1245222760+FKBP3chr1445600003-0.0016798660.99832016
ENST00000366522ENST00000396062EFCAB2chr1245222760+FKBP3chr1445600003-0.0008986840.9991014
ENST00000366522ENST00000216330EFCAB2chr1245222760+FKBP3chr1445600003-0.0008986840.9991014
ENST00000447569ENST00000396062EFCAB2chr1245222760+FKBP3chr1445600003-0.0013912140.99860877
ENST00000447569ENST00000216330EFCAB2chr1245222760+FKBP3chr1445600003-0.0013912140.99860877

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Fusion Genomic Features for EFCAB2-FKBP3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for EFCAB2-FKBP3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:245222760/chr14:45600003)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEFCAB2chr1:245222760chr14:45600003ENST00000366522+48150_185197270.0DomainEF-hand 1
TgeneFKBP3chr1:245222760chr14:45600003ENST0000021633018128_22436225.0DomainPPIase FKBP-type
TgeneFKBP3chr1:245222760chr14:45600003ENST0000039606207128_22436225.0DomainPPIase FKBP-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEFCAB2chr1:245222760chr14:45600003ENST00000366522+48228_263197270.0DomainEF-hand 2
HgeneEFCAB2chr1:245222760chr14:45600003ENST00000366523+48150_18561163.0DomainEF-hand 1
HgeneEFCAB2chr1:245222760chr14:45600003ENST00000366523+48228_26361163.0DomainEF-hand 2
HgeneEFCAB2chr1:245222760chr14:45600003ENST00000447569+37150_18561134.0DomainEF-hand 1
HgeneEFCAB2chr1:245222760chr14:45600003ENST00000447569+37228_26361134.0DomainEF-hand 2


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Fusion Gene Sequence for EFCAB2-FKBP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>25296_25296_1_EFCAB2-FKBP3_EFCAB2_chr1_245222760_ENST00000366522_FKBP3_chr14_45600003_ENST00000216330_length(transcript)=1897nt_BP=732nt
GCAGTTAACAACAAAAATCGAGCAACGCCACGTCGCACAAACAGGACAGGAGGGGGCGAGGGGTGTGTGCGCGCGCGTGCTGTCCCCAAA
TGGATGAGAAATAAGGGAAAGGAGGGGTTGGGGACCGTGTGATGAAGCAACATGCTAGGCCCGGGACAAGTCCGGCTCCGGCCTCGGGTC
TGGAGGGACAAGGCCGGGGGCCGGGTGGCAGACGGGGCCTCTGGTCTTCCCCCAGCGCGAGGGTCGTGGCGCGAAACGGGGACAGGGCGC
GCGCTCGGAGCCTCCTCCCCGCCCCGCCCCGCCCAAGGGTCTTCCTCCCCCGGGATTCAGAGCGGCCCCTCCTCCAGGCCAGGCTCGCCG
CGGGGCGCTGAGCAGGCCGGGACACCGCGGCCGAGGTTATCGTTAGGCATCTCCCAGGCGACCGGCTCCGCAGCAAGATGGCGGACGAGA
AGGACAGGGAAGGGCCTGGGATACAACAGTGATGAGATAAGGCCTCGGACTTTACTGATCGAACATCTAATGGAAGGTGGAAGAAGAGAC
CATCACACAATGACGGTGTTATGGGGAACACAGGAGATAATAGTAGCAGAATTTCACAAAAAAATCAAAGAGGCATTTGAAGTCTTTGAC
CATGAGTCGAATAATACAGTGGATGTGAGAGAGATTGGAACAATTATCAGGTCATTAGGATGCTGTCCTACGGAAGGAGAGCTGCATGAT
CTGATTGCAGAGTTTCTTGCAGAACATAAATTATTAGGAAACATTAAAAATGTGGCCAAGACAGCTAACAAGGACCACTTGGTTACAGCC
TATAACCATCTTTTTGAAACTAAGCGTTTTAAGGGTACTGAAAGTATAAGTAAAGTGTCTGAGCAAGTAAAAAATGTGAAGCTTAATGAA
GATAAACCCAAAGAAACCAAGTCTGAAGAGACCCTGGATGAGGGTCCACCAAAATATACTAAATCTGTTCTGAAAAAGGGAGATAAAACC
AACTTTCCCAAAAAGGGAGATGTTGTTCACTGCTGGTATACAGGAACACTACAAGATGGGACTGTTTTTGATACTAATATTCAAACAAGT
GCAAAGAAGAAGAAAAATGCCAAGCCTTTAAGTTTTAAGGTCGGAGTAGGCAAAGTTATCAGAGGATGGGATGAAGCTCTCTTGACTATG
AGTAAAGGAGAAAAGGCTCGACTGGAGATTGAACCAGAATGGGCTTACGGAAAGAAAGGACAGCCTGATGCCAAAATTCCACCAAATGCA
AAACTCACTTTTGAAGTGGAATTAGTGGATATTGATTGAAATAGCAGTGCTTCAGCTCTAAGGATATTAGCAACAATGATAAAACTTGGC
CTTGAAGAAATTTACACAACTAGTTAGAACTTGTTACTATTGTAAAGGAAGAGTCAACTGGAAAATTCAAGGAGTTAATAAAATTTGTTT
ACTTGGTCCCAGCTTTTGAGAGATAAATCCCTTATGAATCCCTGGTCTAAAATACTTTCCTACAGCTGTGTAAAATACTGGTCAAGGAGA
ACTTTTTCCTTTTACCTCATGTTGTAAACTTAAGTGGCTCAATAAAAATTGATCCACTGTCTTGATCTGACTGTGATTTGTTTGGTGTTA
ATATATTATTGTTCTGATTAGGGAATTGGAACTAAGGACCTCATCAAACCAGGGAGTAACTCCCAGTAAAATTATCTGGACAGATTGCCT
GTATAATGAGAAGGCAAAAGCATAAGGCTTGAGGGGAAACAAAATGCTAAAAGCAGAAAAATCTTGGCAGGAAGATCAAGACCTGAATTT
AGAAAAGGTGTACTTCAAAACCAATGAGCCACTAATAAAGGTGAACATAAGGTTAATATTACTAATTGATCCCCCCAAAATAAATTCATA

>25296_25296_1_EFCAB2-FKBP3_EFCAB2_chr1_245222760_ENST00000366522_FKBP3_chr14_45600003_ENST00000216330_length(amino acids)=385AA_BP=197
MLGPGQVRLRPRVWRDKAGGRVADGASGLPPARGSWRETGTGRALGASSPPRPAQGSSSPGIQSGPSSRPGSPRGAEQAGTPRPRLSLGI
SQATGSAARWRTRRTGKGLGYNSDEIRPRTLLIEHLMEGGRRDHHTMTVLWGTQEIIVAEFHKKIKEAFEVFDHESNNTVDVREIGTIIR
SLGCCPTEGELHDLIAEFLAEHKLLGNIKNVAKTANKDHLVTAYNHLFETKRFKGTESISKVSEQVKNVKLNEDKPKETKSEETLDEGPP
KYTKSVLKKGDKTNFPKKGDVVHCWYTGTLQDGTVFDTNIQTSAKKKKNAKPLSFKVGVGKVIRGWDEALLTMSKGEKARLEIEPEWAYG

--------------------------------------------------------------
>25296_25296_2_EFCAB2-FKBP3_EFCAB2_chr1_245222760_ENST00000366522_FKBP3_chr14_45600003_ENST00000396062_length(transcript)=1897nt_BP=732nt
GCAGTTAACAACAAAAATCGAGCAACGCCACGTCGCACAAACAGGACAGGAGGGGGCGAGGGGTGTGTGCGCGCGCGTGCTGTCCCCAAA
TGGATGAGAAATAAGGGAAAGGAGGGGTTGGGGACCGTGTGATGAAGCAACATGCTAGGCCCGGGACAAGTCCGGCTCCGGCCTCGGGTC
TGGAGGGACAAGGCCGGGGGCCGGGTGGCAGACGGGGCCTCTGGTCTTCCCCCAGCGCGAGGGTCGTGGCGCGAAACGGGGACAGGGCGC
GCGCTCGGAGCCTCCTCCCCGCCCCGCCCCGCCCAAGGGTCTTCCTCCCCCGGGATTCAGAGCGGCCCCTCCTCCAGGCCAGGCTCGCCG
CGGGGCGCTGAGCAGGCCGGGACACCGCGGCCGAGGTTATCGTTAGGCATCTCCCAGGCGACCGGCTCCGCAGCAAGATGGCGGACGAGA
AGGACAGGGAAGGGCCTGGGATACAACAGTGATGAGATAAGGCCTCGGACTTTACTGATCGAACATCTAATGGAAGGTGGAAGAAGAGAC
CATCACACAATGACGGTGTTATGGGGAACACAGGAGATAATAGTAGCAGAATTTCACAAAAAAATCAAAGAGGCATTTGAAGTCTTTGAC
CATGAGTCGAATAATACAGTGGATGTGAGAGAGATTGGAACAATTATCAGGTCATTAGGATGCTGTCCTACGGAAGGAGAGCTGCATGAT
CTGATTGCAGAGTTTCTTGCAGAACATAAATTATTAGGAAACATTAAAAATGTGGCCAAGACAGCTAACAAGGACCACTTGGTTACAGCC
TATAACCATCTTTTTGAAACTAAGCGTTTTAAGGGTACTGAAAGTATAAGTAAAGTGTCTGAGCAAGTAAAAAATGTGAAGCTTAATGAA
GATAAACCCAAAGAAACCAAGTCTGAAGAGACCCTGGATGAGGGTCCACCAAAATATACTAAATCTGTTCTGAAAAAGGGAGATAAAACC
AACTTTCCCAAAAAGGGAGATGTTGTTCACTGCTGGTATACAGGAACACTACAAGATGGGACTGTTTTTGATACTAATATTCAAACAAGT
GCAAAGAAGAAGAAAAATGCCAAGCCTTTAAGTTTTAAGGTCGGAGTAGGCAAAGTTATCAGAGGATGGGATGAAGCTCTCTTGACTATG
AGTAAAGGAGAAAAGGCTCGACTGGAGATTGAACCAGAATGGGCTTACGGAAAGAAAGGACAGCCTGATGCCAAAATTCCACCAAATGCA
AAACTCACTTTTGAAGTGGAATTAGTGGATATTGATTGAAATAGCAGTGCTTCAGCTCTAAGGATATTAGCAACAATGATAAAACTTGGC
CTTGAAGAAATTTACACAACTAGTTAGAACTTGTTACTATTGTAAAGGAAGAGTCAACTGGAAAATTCAAGGAGTTAATAAAATTTGTTT
ACTTGGTCCCAGCTTTTGAGAGATAAATCCCTTATGAATCCCTGGTCTAAAATACTTTCCTACAGCTGTGTAAAATACTGGTCAAGGAGA
ACTTTTTCCTTTTACCTCATGTTGTAAACTTAAGTGGCTCAATAAAAATTGATCCACTGTCTTGATCTGACTGTGATTTGTTTGGTGTTA
ATATATTATTGTTCTGATTAGGGAATTGGAACTAAGGACCTCATCAAACCAGGGAGTAACTCCCAGTAAAATTATCTGGACAGATTGCCT
GTATAATGAGAAGGCAAAAGCATAAGGCTTGAGGGGAAACAAAATGCTAAAAGCAGAAAAATCTTGGCAGGAAGATCAAGACCTGAATTT
AGAAAAGGTGTACTTCAAAACCAATGAGCCACTAATAAAGGTGAACATAAGGTTAATATTACTAATTGATCCCCCCAAAATAAATTCATA

>25296_25296_2_EFCAB2-FKBP3_EFCAB2_chr1_245222760_ENST00000366522_FKBP3_chr14_45600003_ENST00000396062_length(amino acids)=385AA_BP=197
MLGPGQVRLRPRVWRDKAGGRVADGASGLPPARGSWRETGTGRALGASSPPRPAQGSSSPGIQSGPSSRPGSPRGAEQAGTPRPRLSLGI
SQATGSAARWRTRRTGKGLGYNSDEIRPRTLLIEHLMEGGRRDHHTMTVLWGTQEIIVAEFHKKIKEAFEVFDHESNNTVDVREIGTIIR
SLGCCPTEGELHDLIAEFLAEHKLLGNIKNVAKTANKDHLVTAYNHLFETKRFKGTESISKVSEQVKNVKLNEDKPKETKSEETLDEGPP
KYTKSVLKKGDKTNFPKKGDVVHCWYTGTLQDGTVFDTNIQTSAKKKKNAKPLSFKVGVGKVIRGWDEALLTMSKGEKARLEIEPEWAYG

--------------------------------------------------------------
>25296_25296_3_EFCAB2-FKBP3_EFCAB2_chr1_245222760_ENST00000366523_FKBP3_chr14_45600003_ENST00000216330_length(transcript)=1613nt_BP=448nt
GGGAGGCGGGCTGCGAATGGGAAGCGGGAGGAGGAGGCCGGGCCGCGGGCTGGTTCTATCACCCCCTTGGGAGCCCAGCTCTTCACCTAG
CTCTCCGGCGCTTTTCAAAATCTGCAGTTAACAACAAAAATCGAGCAACGCCACGTCGCACAAACAGGACAGGAGGGGGCGAGGGGCCAG
GCTCGCCGCGGGGCGCTGAGCAGGCCGGGACACCGCGGCCGAGGTTATCGTTAGGCATCTCCCAGGCGACCGGCTCCGCAGCAAGATGGC
GGACGAGAAGGACAGGGAAGAGATAATAGTAGCAGAATTTCACAAAAAAATCAAAGAGGCATTTGAAGTCTTTGACCATGAGTCGAATAA
TACAGTGGATGTGAGAGAGATTGGAACAATTATCAGGTCATTAGGATGCTGTCCTACGGAAGGAGAGCTGCATGATCTGATTGCAGAGTT
TCTTGCAGAACATAAATTATTAGGAAACATTAAAAATGTGGCCAAGACAGCTAACAAGGACCACTTGGTTACAGCCTATAACCATCTTTT
TGAAACTAAGCGTTTTAAGGGTACTGAAAGTATAAGTAAAGTGTCTGAGCAAGTAAAAAATGTGAAGCTTAATGAAGATAAACCCAAAGA
AACCAAGTCTGAAGAGACCCTGGATGAGGGTCCACCAAAATATACTAAATCTGTTCTGAAAAAGGGAGATAAAACCAACTTTCCCAAAAA
GGGAGATGTTGTTCACTGCTGGTATACAGGAACACTACAAGATGGGACTGTTTTTGATACTAATATTCAAACAAGTGCAAAGAAGAAGAA
AAATGCCAAGCCTTTAAGTTTTAAGGTCGGAGTAGGCAAAGTTATCAGAGGATGGGATGAAGCTCTCTTGACTATGAGTAAAGGAGAAAA
GGCTCGACTGGAGATTGAACCAGAATGGGCTTACGGAAAGAAAGGACAGCCTGATGCCAAAATTCCACCAAATGCAAAACTCACTTTTGA
AGTGGAATTAGTGGATATTGATTGAAATAGCAGTGCTTCAGCTCTAAGGATATTAGCAACAATGATAAAACTTGGCCTTGAAGAAATTTA
CACAACTAGTTAGAACTTGTTACTATTGTAAAGGAAGAGTCAACTGGAAAATTCAAGGAGTTAATAAAATTTGTTTACTTGGTCCCAGCT
TTTGAGAGATAAATCCCTTATGAATCCCTGGTCTAAAATACTTTCCTACAGCTGTGTAAAATACTGGTCAAGGAGAACTTTTTCCTTTTA
CCTCATGTTGTAAACTTAAGTGGCTCAATAAAAATTGATCCACTGTCTTGATCTGACTGTGATTTGTTTGGTGTTAATATATTATTGTTC
TGATTAGGGAATTGGAACTAAGGACCTCATCAAACCAGGGAGTAACTCCCAGTAAAATTATCTGGACAGATTGCCTGTATAATGAGAAGG
CAAAAGCATAAGGCTTGAGGGGAAACAAAATGCTAAAAGCAGAAAAATCTTGGCAGGAAGATCAAGACCTGAATTTAGAAAAGGTGTACT

>25296_25296_3_EFCAB2-FKBP3_EFCAB2_chr1_245222760_ENST00000366523_FKBP3_chr14_45600003_ENST00000216330_length(amino acids)=249AA_BP=61
MADEKDREEIIVAEFHKKIKEAFEVFDHESNNTVDVREIGTIIRSLGCCPTEGELHDLIAEFLAEHKLLGNIKNVAKTANKDHLVTAYNH
LFETKRFKGTESISKVSEQVKNVKLNEDKPKETKSEETLDEGPPKYTKSVLKKGDKTNFPKKGDVVHCWYTGTLQDGTVFDTNIQTSAKK

--------------------------------------------------------------
>25296_25296_4_EFCAB2-FKBP3_EFCAB2_chr1_245222760_ENST00000366523_FKBP3_chr14_45600003_ENST00000396062_length(transcript)=1613nt_BP=448nt
GGGAGGCGGGCTGCGAATGGGAAGCGGGAGGAGGAGGCCGGGCCGCGGGCTGGTTCTATCACCCCCTTGGGAGCCCAGCTCTTCACCTAG
CTCTCCGGCGCTTTTCAAAATCTGCAGTTAACAACAAAAATCGAGCAACGCCACGTCGCACAAACAGGACAGGAGGGGGCGAGGGGCCAG
GCTCGCCGCGGGGCGCTGAGCAGGCCGGGACACCGCGGCCGAGGTTATCGTTAGGCATCTCCCAGGCGACCGGCTCCGCAGCAAGATGGC
GGACGAGAAGGACAGGGAAGAGATAATAGTAGCAGAATTTCACAAAAAAATCAAAGAGGCATTTGAAGTCTTTGACCATGAGTCGAATAA
TACAGTGGATGTGAGAGAGATTGGAACAATTATCAGGTCATTAGGATGCTGTCCTACGGAAGGAGAGCTGCATGATCTGATTGCAGAGTT
TCTTGCAGAACATAAATTATTAGGAAACATTAAAAATGTGGCCAAGACAGCTAACAAGGACCACTTGGTTACAGCCTATAACCATCTTTT
TGAAACTAAGCGTTTTAAGGGTACTGAAAGTATAAGTAAAGTGTCTGAGCAAGTAAAAAATGTGAAGCTTAATGAAGATAAACCCAAAGA
AACCAAGTCTGAAGAGACCCTGGATGAGGGTCCACCAAAATATACTAAATCTGTTCTGAAAAAGGGAGATAAAACCAACTTTCCCAAAAA
GGGAGATGTTGTTCACTGCTGGTATACAGGAACACTACAAGATGGGACTGTTTTTGATACTAATATTCAAACAAGTGCAAAGAAGAAGAA
AAATGCCAAGCCTTTAAGTTTTAAGGTCGGAGTAGGCAAAGTTATCAGAGGATGGGATGAAGCTCTCTTGACTATGAGTAAAGGAGAAAA
GGCTCGACTGGAGATTGAACCAGAATGGGCTTACGGAAAGAAAGGACAGCCTGATGCCAAAATTCCACCAAATGCAAAACTCACTTTTGA
AGTGGAATTAGTGGATATTGATTGAAATAGCAGTGCTTCAGCTCTAAGGATATTAGCAACAATGATAAAACTTGGCCTTGAAGAAATTTA
CACAACTAGTTAGAACTTGTTACTATTGTAAAGGAAGAGTCAACTGGAAAATTCAAGGAGTTAATAAAATTTGTTTACTTGGTCCCAGCT
TTTGAGAGATAAATCCCTTATGAATCCCTGGTCTAAAATACTTTCCTACAGCTGTGTAAAATACTGGTCAAGGAGAACTTTTTCCTTTTA
CCTCATGTTGTAAACTTAAGTGGCTCAATAAAAATTGATCCACTGTCTTGATCTGACTGTGATTTGTTTGGTGTTAATATATTATTGTTC
TGATTAGGGAATTGGAACTAAGGACCTCATCAAACCAGGGAGTAACTCCCAGTAAAATTATCTGGACAGATTGCCTGTATAATGAGAAGG
CAAAAGCATAAGGCTTGAGGGGAAACAAAATGCTAAAAGCAGAAAAATCTTGGCAGGAAGATCAAGACCTGAATTTAGAAAAGGTGTACT

>25296_25296_4_EFCAB2-FKBP3_EFCAB2_chr1_245222760_ENST00000366523_FKBP3_chr14_45600003_ENST00000396062_length(amino acids)=249AA_BP=61
MADEKDREEIIVAEFHKKIKEAFEVFDHESNNTVDVREIGTIIRSLGCCPTEGELHDLIAEFLAEHKLLGNIKNVAKTANKDHLVTAYNH
LFETKRFKGTESISKVSEQVKNVKLNEDKPKETKSEETLDEGPPKYTKSVLKKGDKTNFPKKGDVVHCWYTGTLQDGTVFDTNIQTSAKK

--------------------------------------------------------------
>25296_25296_5_EFCAB2-FKBP3_EFCAB2_chr1_245222760_ENST00000447569_FKBP3_chr14_45600003_ENST00000216330_length(transcript)=1440nt_BP=275nt
AGGCCAGGCTCGCCGCGGGGCGCTGAGCAGGCCGGGACACCGCGGCCGAGGTTATCGTTAGGCATCTCCCAGGCGACCGGCTCCGCAGCA
AGATGGCGGACGAGAAGGACAGGGAAGAGATAATAGTAGCAGAATTTCACAAAAAAATCAAAGAGGCATTTGAAGTCTTTGACCATGAGT
CGAATAATACAGTGGATGTGAGAGAGATTGGAACAATTATCAGGTCATTAGGATGCTGTCCTACGGAAGGAGAGCTGCATGATCTGATTG
CAGAGTTTCTTGCAGAACATAAATTATTAGGAAACATTAAAAATGTGGCCAAGACAGCTAACAAGGACCACTTGGTTACAGCCTATAACC
ATCTTTTTGAAACTAAGCGTTTTAAGGGTACTGAAAGTATAAGTAAAGTGTCTGAGCAAGTAAAAAATGTGAAGCTTAATGAAGATAAAC
CCAAAGAAACCAAGTCTGAAGAGACCCTGGATGAGGGTCCACCAAAATATACTAAATCTGTTCTGAAAAAGGGAGATAAAACCAACTTTC
CCAAAAAGGGAGATGTTGTTCACTGCTGGTATACAGGAACACTACAAGATGGGACTGTTTTTGATACTAATATTCAAACAAGTGCAAAGA
AGAAGAAAAATGCCAAGCCTTTAAGTTTTAAGGTCGGAGTAGGCAAAGTTATCAGAGGATGGGATGAAGCTCTCTTGACTATGAGTAAAG
GAGAAAAGGCTCGACTGGAGATTGAACCAGAATGGGCTTACGGAAAGAAAGGACAGCCTGATGCCAAAATTCCACCAAATGCAAAACTCA
CTTTTGAAGTGGAATTAGTGGATATTGATTGAAATAGCAGTGCTTCAGCTCTAAGGATATTAGCAACAATGATAAAACTTGGCCTTGAAG
AAATTTACACAACTAGTTAGAACTTGTTACTATTGTAAAGGAAGAGTCAACTGGAAAATTCAAGGAGTTAATAAAATTTGTTTACTTGGT
CCCAGCTTTTGAGAGATAAATCCCTTATGAATCCCTGGTCTAAAATACTTTCCTACAGCTGTGTAAAATACTGGTCAAGGAGAACTTTTT
CCTTTTACCTCATGTTGTAAACTTAAGTGGCTCAATAAAAATTGATCCACTGTCTTGATCTGACTGTGATTTGTTTGGTGTTAATATATT
ATTGTTCTGATTAGGGAATTGGAACTAAGGACCTCATCAAACCAGGGAGTAACTCCCAGTAAAATTATCTGGACAGATTGCCTGTATAAT
GAGAAGGCAAAAGCATAAGGCTTGAGGGGAAACAAAATGCTAAAAGCAGAAAAATCTTGGCAGGAAGATCAAGACCTGAATTTAGAAAAG
GTGTACTTCAAAACCAATGAGCCACTAATAAAGGTGAACATAAGGTTAATATTACTAATTGATCCCCCCAAAATAAATTCATAAACAATT

>25296_25296_5_EFCAB2-FKBP3_EFCAB2_chr1_245222760_ENST00000447569_FKBP3_chr14_45600003_ENST00000216330_length(amino acids)=249AA_BP=61
MADEKDREEIIVAEFHKKIKEAFEVFDHESNNTVDVREIGTIIRSLGCCPTEGELHDLIAEFLAEHKLLGNIKNVAKTANKDHLVTAYNH
LFETKRFKGTESISKVSEQVKNVKLNEDKPKETKSEETLDEGPPKYTKSVLKKGDKTNFPKKGDVVHCWYTGTLQDGTVFDTNIQTSAKK

--------------------------------------------------------------
>25296_25296_6_EFCAB2-FKBP3_EFCAB2_chr1_245222760_ENST00000447569_FKBP3_chr14_45600003_ENST00000396062_length(transcript)=1440nt_BP=275nt
AGGCCAGGCTCGCCGCGGGGCGCTGAGCAGGCCGGGACACCGCGGCCGAGGTTATCGTTAGGCATCTCCCAGGCGACCGGCTCCGCAGCA
AGATGGCGGACGAGAAGGACAGGGAAGAGATAATAGTAGCAGAATTTCACAAAAAAATCAAAGAGGCATTTGAAGTCTTTGACCATGAGT
CGAATAATACAGTGGATGTGAGAGAGATTGGAACAATTATCAGGTCATTAGGATGCTGTCCTACGGAAGGAGAGCTGCATGATCTGATTG
CAGAGTTTCTTGCAGAACATAAATTATTAGGAAACATTAAAAATGTGGCCAAGACAGCTAACAAGGACCACTTGGTTACAGCCTATAACC
ATCTTTTTGAAACTAAGCGTTTTAAGGGTACTGAAAGTATAAGTAAAGTGTCTGAGCAAGTAAAAAATGTGAAGCTTAATGAAGATAAAC
CCAAAGAAACCAAGTCTGAAGAGACCCTGGATGAGGGTCCACCAAAATATACTAAATCTGTTCTGAAAAAGGGAGATAAAACCAACTTTC
CCAAAAAGGGAGATGTTGTTCACTGCTGGTATACAGGAACACTACAAGATGGGACTGTTTTTGATACTAATATTCAAACAAGTGCAAAGA
AGAAGAAAAATGCCAAGCCTTTAAGTTTTAAGGTCGGAGTAGGCAAAGTTATCAGAGGATGGGATGAAGCTCTCTTGACTATGAGTAAAG
GAGAAAAGGCTCGACTGGAGATTGAACCAGAATGGGCTTACGGAAAGAAAGGACAGCCTGATGCCAAAATTCCACCAAATGCAAAACTCA
CTTTTGAAGTGGAATTAGTGGATATTGATTGAAATAGCAGTGCTTCAGCTCTAAGGATATTAGCAACAATGATAAAACTTGGCCTTGAAG
AAATTTACACAACTAGTTAGAACTTGTTACTATTGTAAAGGAAGAGTCAACTGGAAAATTCAAGGAGTTAATAAAATTTGTTTACTTGGT
CCCAGCTTTTGAGAGATAAATCCCTTATGAATCCCTGGTCTAAAATACTTTCCTACAGCTGTGTAAAATACTGGTCAAGGAGAACTTTTT
CCTTTTACCTCATGTTGTAAACTTAAGTGGCTCAATAAAAATTGATCCACTGTCTTGATCTGACTGTGATTTGTTTGGTGTTAATATATT
ATTGTTCTGATTAGGGAATTGGAACTAAGGACCTCATCAAACCAGGGAGTAACTCCCAGTAAAATTATCTGGACAGATTGCCTGTATAAT
GAGAAGGCAAAAGCATAAGGCTTGAGGGGAAACAAAATGCTAAAAGCAGAAAAATCTTGGCAGGAAGATCAAGACCTGAATTTAGAAAAG
GTGTACTTCAAAACCAATGAGCCACTAATAAAGGTGAACATAAGGTTAATATTACTAATTGATCCCCCCAAAATAAATTCATAAACAATT

>25296_25296_6_EFCAB2-FKBP3_EFCAB2_chr1_245222760_ENST00000447569_FKBP3_chr14_45600003_ENST00000396062_length(amino acids)=249AA_BP=61
MADEKDREEIIVAEFHKKIKEAFEVFDHESNNTVDVREIGTIIRSLGCCPTEGELHDLIAEFLAEHKLLGNIKNVAKTANKDHLVTAYNH
LFETKRFKGTESISKVSEQVKNVKLNEDKPKETKSEETLDEGPPKYTKSVLKKGDKTNFPKKGDVVHCWYTGTLQDGTVFDTNIQTSAKK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for EFCAB2-FKBP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EFCAB2-FKBP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EFCAB2-FKBP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource