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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:EFCAB2-KIF26B (FusionGDB2 ID:HG84288TG55083)

Fusion Gene Summary for EFCAB2-KIF26B

check button Fusion gene summary
Fusion gene informationFusion gene name: EFCAB2-KIF26B
Fusion gene ID: hg84288tg55083
HgeneTgene
Gene symbol

EFCAB2

KIF26B

Gene ID

84288

55083

Gene nameEF-hand calcium binding domain 2kinesin family member 26B
SynonymsCFAP200|DRC8-
Cytomap('EFCAB2')('KIF26B')

1q44

1q44

Type of geneprotein-codingprotein-coding
Descriptiondynein regulatory complex protein 8EF-hand calcium-binding domain-containing protein 2dynein regulatory complex subunit 8kinesin-like protein KIF26B
Modification date2020031320200322
UniProtAcc.

Q2KJY2

Ensembl transtripts involved in fusion geneENST00000487845, ENST00000366522, 
ENST00000366523, ENST00000447569, 
ENST00000487845, ENST00000366522, 
ENST00000366523, ENST00000447569, 
Fusion gene scores* DoF score4 X 4 X 3=489 X 9 X 6=486
# samples 511
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(11/486*10)=-2.14345279008112
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EFCAB2 [Title/Abstract] AND KIF26B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEFCAB2(245246990)-KIF26B(245530136), # samples:2
Anticipated loss of major functional domain due to fusion event.KIF26B-EFCAB2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KIF26B-EFCAB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EFCAB2-KIF26B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EFCAB2-KIF26B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EFCAB2-KIF26B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EFCAB2-KIF26B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EFCAB2-KIF26B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across EFCAB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across KIF26B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-02-0047-01AEFCAB2chr1

245246990

+KIF26Bchr1

245530136

+
ChimerDB4SKCMTCGA-ER-A197-06AEFCAB2chr1

245133745

+KIF26Bchr1

245530136

+
ChimerDB4THCATCGA-IM-A3ED-01AEFCAB2chr1

245246990

+KIF26Bchr1

245530136

+


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Fusion Gene ORF analysis for EFCAB2-KIF26B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000487845ENST00000407071EFCAB2chr1

245246990

+KIF26Bchr1

245530136

+
3UTR-3CDSENST00000487845ENST00000407071EFCAB2chr1

245133745

+KIF26Bchr1

245530136

+
3UTR-3UTRENST00000487845ENST00000479506EFCAB2chr1

245246990

+KIF26Bchr1

245530136

+
3UTR-3UTRENST00000487845ENST00000479506EFCAB2chr1

245133745

+KIF26Bchr1

245530136

+
3UTR-intronENST00000487845ENST00000366518EFCAB2chr1

245246990

+KIF26Bchr1

245530136

+
3UTR-intronENST00000487845ENST00000366518EFCAB2chr1

245133745

+KIF26Bchr1

245530136

+
5CDS-3UTRENST00000366522ENST00000479506EFCAB2chr1

245246990

+KIF26Bchr1

245530136

+
5CDS-3UTRENST00000366522ENST00000479506EFCAB2chr1

245133745

+KIF26Bchr1

245530136

+
5CDS-3UTRENST00000366523ENST00000479506EFCAB2chr1

245246990

+KIF26Bchr1

245530136

+
5CDS-3UTRENST00000366523ENST00000479506EFCAB2chr1

245133745

+KIF26Bchr1

245530136

+
5CDS-3UTRENST00000447569ENST00000479506EFCAB2chr1

245246990

+KIF26Bchr1

245530136

+
5CDS-3UTRENST00000447569ENST00000479506EFCAB2chr1

245133745

+KIF26Bchr1

245530136

+
5CDS-intronENST00000366522ENST00000366518EFCAB2chr1

245246990

+KIF26Bchr1

245530136

+
5CDS-intronENST00000366522ENST00000366518EFCAB2chr1

245133745

+KIF26Bchr1

245530136

+
5CDS-intronENST00000366523ENST00000366518EFCAB2chr1

245246990

+KIF26Bchr1

245530136

+
5CDS-intronENST00000366523ENST00000366518EFCAB2chr1

245133745

+KIF26Bchr1

245530136

+
5CDS-intronENST00000447569ENST00000366518EFCAB2chr1

245246990

+KIF26Bchr1

245530136

+
5CDS-intronENST00000447569ENST00000366518EFCAB2chr1

245133745

+KIF26Bchr1

245530136

+
Frame-shiftENST00000366522ENST00000407071EFCAB2chr1

245246990

+KIF26Bchr1

245530136

+
Frame-shiftENST00000366523ENST00000407071EFCAB2chr1

245246990

+KIF26Bchr1

245530136

+
Frame-shiftENST00000366523ENST00000407071EFCAB2chr1

245133745

+KIF26Bchr1

245530136

+
Frame-shiftENST00000447569ENST00000407071EFCAB2chr1

245246990

+KIF26Bchr1

245530136

+
Frame-shiftENST00000447569ENST00000407071EFCAB2chr1

245133745

+KIF26Bchr1

245530136

+
In-frameENST00000366522ENST00000407071EFCAB2chr1

245133745

+KIF26Bchr1

245530136

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000366522EFCAB2chr1245133745+ENST00000407071KIF26Bchr1245530136+684446214163232060

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000366522ENST00000407071EFCAB2chr1245133745+KIF26Bchr1245530136+0.0083522120.9916477

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Fusion Genomic Features for EFCAB2-KIF26B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EFCAB2chr1245246990+KIF26Bchr1245530135+5.04E-101
EFCAB2chr1245133745+KIF26Bchr1245530135+7.49E-121
EFCAB2chr1245246990+KIF26Bchr1245530135+5.04E-101
EFCAB2chr1245246990+KIF26Bchr1245530135+5.04E-101
EFCAB2chr1245133745+KIF26Bchr1245530135+7.49E-121
EFCAB2chr1245246990+KIF26Bchr1245530135+5.04E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for EFCAB2-KIF26B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:245246990/chr1:245530136)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KIF26B

Q2KJY2

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKIF26Bchr1:245133745chr1:245530136ENST000004070711151649_17971552109.0Compositional biasNote=Ser-rich
TgeneKIF26Bchr1:245133745chr1:245530136ENST00000407071115450_8011552109.0DomainKinesin motor
TgeneKIF26Bchr1:245133745chr1:245530136ENST00000407071115546_5531552109.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEFCAB2chr1:245133745chr1:245530136ENST00000366522+18150_185107270.0DomainEF-hand 1
HgeneEFCAB2chr1:245133745chr1:245530136ENST00000366522+18228_263107270.0DomainEF-hand 2
HgeneEFCAB2chr1:245133745chr1:245530136ENST00000366523+28150_1858163.0DomainEF-hand 1
HgeneEFCAB2chr1:245133745chr1:245530136ENST00000366523+28228_2638163.0DomainEF-hand 2
HgeneEFCAB2chr1:245133745chr1:245530136ENST00000447569+17150_1858134.0DomainEF-hand 1
HgeneEFCAB2chr1:245133745chr1:245530136ENST00000447569+17228_2638134.0DomainEF-hand 2
TgeneKIF26Bchr1:245133745chr1:245530136ENST0000040707111558_1261552109.0Compositional biasNote=Gly-rich


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Fusion Gene Sequence for EFCAB2-KIF26B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>25298_25298_1_EFCAB2-KIF26B_EFCAB2_chr1_245133745_ENST00000366522_KIF26B_chr1_245530136_ENST00000407071_length(transcript)=6844nt_BP=462nt
GCAGTTAACAACAAAAATCGAGCAACGCCACGTCGCACAAACAGGACAGGAGGGGGCGAGGGGTGTGTGCGCGCGCGTGCTGTCCCCAAA
TGGATGAGAAATAAGGGAAAGGAGGGGTTGGGGACCGTGTGATGAAGCAACATGCTAGGCCCGGGACAAGTCCGGCTCCGGCCTCGGGTC
TGGAGGGACAAGGCCGGGGGCCGGGTGGCAGACGGGGCCTCTGGTCTTCCCCCAGCGCGAGGGTCGTGGCGCGAAACGGGGACAGGGCGC
GCGCTCGGAGCCTCCTCCCCGCCCCGCCCCGCCCAAGGGTCTTCCTCCCCCGGGATTCAGAGCGGCCCCTCCTCCAGGCCAGGCTCGCCG
CGGGGCGCTGAGCAGGCCGGGACACCGCGGCCGAGGTTATCGTTAGGCATCTCCCAGGCGACCGGCTCCGCAGCAAGATGGCGGACGAGA
AGGACAGGGAAGGACCCTGCTTTCTCGGCTGTGATTCACGACAAACTCCAGGTCCCCAACACCATCCGGAAGGCATGGAACGACCGGGAC
AACCGCTGTGACATTTGCGCCACTCACCTGAACCAGTTGAAGCAGGAGGCCATCCAGATGGTGCTGACGTTGGAGCAGGCAGCCGGCAGT
GAGCACTACGACGCCTCGCCCTGCTCCCCGCCACCGCTCTCCAACATCCCCACCCTGGTGGGGTCCCGGCACGTGGGTGGGCTCCAGCAG
CCCAGAGACTGGGCCTTTGTGCCCGCCCCCTGTGCCACCTCCAACTACACAGGCTTCGCCAACAAGCACGGCAGCAAACCCAGCAGCCTT
GGGGTCAGCAATGGGGCGGAAAAGAAGAGCGGGTCCCCAACCCACCAGGCCAAGGTCAGCCTCCAGATGGCCACCAGTCCAAGCAATGGG
AACATCCTCAATTCGGTGGCCATCCAGGCTCACCAGTACCTGGATGGCACCTGGTCCCTGTCGAGAACCAACGGGGTCACCCTGTACCCA
TACCAGATCTCCCAGCTGATGACAGAGAGTAGCCGGGAGGGACTAACAGAAGCAGTGCTGAACCGCTACAATGCAGACAAGCCTTCCGCC
TGCAGTGTCCCAGCCTCGCAGGGCTCCTGCGTGGCCAGCGAGACTTCCACAGGCACATCGGTGGCCGCCTCCTTCTTTGCACGAGCTGCC
CAGAAGTTAAATCTGTCTTCTAAAAAGAAGAAACATCGGCCTTCCACTTCTTCCGCTGCCGAACCACCGCTCTTTGCAACCAGCTTCAGT
GGGATTCTGCAGACCTCCCCTCCCCCAGCCCCACCCTGCCTGCTGAGGGCTGTCAACAAGGTGAAGGACACCCCGGGGCTGGGCAAGGTG
AAAGTCATGCTTCGCATCTGTTCCACCTTGGCTCGAGATACTTCAGAATCCAGCTCTTTCTTAAAGGTGGACCCACGGAAGAAGCAGATC
ACCTTGTACGATCCCCTGACTTGTGGAGGTCAAAATGCCTTCCAAAAGAGAGGCAACCAGGTTCCTCCAAAGATGTTTGCCTTCGATGCA
GTTTTTCCACAAGACGCTTCTCAGGCTGAAGTGTGTGCAGGCACCGTGGCAGAGGTGATCCAGTCTGTGGTCAACGGGGCAGATGGCTGC
GTGTTCTGTTTCGGCCACGCCAAACTGGGAAAATCCTACACCATGATCGGAAAGGATGATTCCATGCAGAACCTGGGCATCATTCCCTGT
GCCATCTCTTGGCTCTTCAAGCTCATAAACGAACGCAAGGAAAAGACCGGCGCCCGTTTCTCAGTCCGGGTTTCCGCCGTGGAAGTGTGG
GGGAAGGAGGAGAACCTGCGGGACCTGCTGTCGGAGGTGGCCACGGGCAGCCTGCAGGACGGCCAGTCCCCGGGCGTGTACCTCTGTGAG
GACCCCATCTGCGGCACGCAGCTGCAGAACCAGAGCGAGCTGCGGGCCCCCACCGCAGAGAAGGCTGCCTTTTTCCTGGATGCCGCCATT
GCCTCCCGCAGGAGCCACCAACAGGACTGTGATGAGGACGACCACCGCAACTCACACGTGTTCTTCACACTGCACATCTACCAGTACCGG
ATGGAGAAGAGCGGGAAAGGGGGAATGTCTGGAGGTCGCAGCCGCCTGCATCTCATTGATCTCGGCAGCTGTGTGAAAGCTCTTAGCAAA
AATCGAGAAGGAGGCTCAGGGCTGTGTCTCTCGCTGTCTGCTCTGGGCAATGTCATCCTGGCTCTCGTCAATGGCAGCAAACACATTCCA
TACAAAGAGAGCAAGCTCGCCATGTTGCTGCGGGAGTCTCTGGGGAACATGAACTGCCGTACCACCATGATCGCGCACATCTCGGCCGCG
GTCGGGAGCTACGCGGAGACCCTGTCCACCATCCAGATTGCATCGAGAGTCTTGAGGATGAAGAAAAAGAAGACGAAGTACACATCCAGC
TCGTCCGGCGGGGAGAGCTCCTGCGAAGAAGGCCGCATGCGCAGGCCCACCCAGCTGAGACCCTTCCACACCAGGGCCACGGTGGACCCT
GACTTCCCCATCGCTCACCTGTCCAGCGACCCCGACTACTCCTCCAGCAGCGAGCAGTCCTGCGACACCGTCATCTACATCGGGCCCAAC
GGCACGGCCCTCTCTGACAAGGAGCTCACCGACAACGAGGGCCCCCCAGACTTTGTCCCTATCGTGCCAGCCCTGCAGAAGACCCGGGGC
GACAGCCGGCCCGCAGAGGCAGGAGAGGCTGCAGCCGGCAAGTCAGAAAGGGACTGCCTGAAGTGCAACACGTTTGCCGAGCTGCAGGAG
AGGCTGGACTGCATCGACGGCAGCGAGGAGCCCAGCAGCTTTCCTTTCGAAGAACTGCCTGCTCAGTTTGGGCCAGAGCAGGCAAGCAGA
GGCCCCCGGTTAAGCCAAGCAGCGGGGGCAAGCCCACTCTCTGAGTCTGATAAGGAAGATAATGGGTCCGAAGGTCAGCTGACCAACAGA
GAAGGCCCTGAACTCCCAGCCTCCAAGATGCAGAGGAGTCACTCACCTGTGCCCGCCGCGGCACCCGCCCACAGCCCCAGCCCGGCCTCA
CCCAGGAGCGTCCCGGGCAGCAGTAGCCAGCACAGCGCCTCCCCACTCGTGCAGAGCCCCAGCCTCCAGAGCAGCCGGGAGAGCCTCAAC
TCCTGCGGCTTCGTGGAAGGCAAGCCCAGGCCCATGGGCTCCCCCCGGCTGGGCATCGCCAGCCTGTCCAAGACCTCGGAGTACAAGCCA
CCCAGCTCTCCTTCCCAGAGATGCAAAGTCTACACCCAGAAGGGGGTCCTGCCGTCTCCCGCCCCACTGCCTCCCTCGAGCAAGGATTCC
GGCGTGGCGTCTAGGGAGTCCTTGCTGCAGCCCGAGGTGCGTACGCCCCCGGTTGGAATGAGCCCCCAGGTTTTGAAAAAATCCATGTCT
GCTGGGAGCGAAGGGTTCCCGGAAACTCCTGTCGATGATGAGCAGCAGGCAGCTACTCCTTCAGAGTCCAAGAAGGAGATCCTGAGCACC
ACGATGGTGACGGTGCAGCAGCCACTGGAGCTGAACGGTGAGGACGAGCTGGTGTTCACGCTGGTGGAGGAGCTGACCATCAGCGGGGTC
CTGGACAGCGGCCGCCCCACCAGCATCATCAGCTTCAACAGCGACTGCTCTGCACGGGCCCTGGCCTCGGGCTCGCGGCCCGTCAGCATC
ATCAGCAGCATCAGCGAGGACCTGGAGTGCTACTCCAGCACGGCCCCCGTCTCCGAGGTCAGCATCACACAGTTCTTGCCCCTCCCGAAG
ATGAGCCTGGATGAGAAGGCCCAGGACGCAGGGAGCAGACGCTCTTCCATCAGCTCCTGGCTGAGCGAGATGAGCGCGGGCAGTGAGGGT
GAGCAGTCGTGCCACAGTTTCATAGCCCAGACGTGTTTTGGGCACGGGGAGGCAATGGCAGAACCTGTGGCCTCGGAGTTTGTCAGCAGC
CTCCAGAACACCGCTGTGGTGTGCAGAGAGAAGCCCAAGGCCAGCCCCGACAACTTGCTCATCCTGTCTGAGATGGGAGATGACTCTTTC
AACAAAGCAGCCCCCATCAAAGGCTGCAAAATATCCACAGTGAGCAAGGCCATGGTCACCATCTCCAACACGGCCAATCTGAGCAGCTGC
GAGGGGTACATCCCCATGAAGACCAATATCACAGTTTACCCCTGCATTGCCATGAGCCCCCGGAACATCCAAGAGCCGGAGGCCCCCACC
GCCACCCCCAAAGCAGGCCCCACATTAGCCCAGTCCCGGGAGAGTAAGGAAAACAGTGCAAAGAAAGAGATGAAATTTGAGGACCCGTGG
CTGAAACGAGAAGAGGAAGTGAAAAAAGAGACGGCTCATCCCAATGAAGAAGGGATGATGAGGTGTGAGACTGCCACGGGCCCCTCGAAT
GCTGAGACCAGAGCAGAGCAGGAGCAGGACGGAAAGCCCAGTCCGGGAGACAGGCTCAGCAGCAGCAGCGGAGAGGTGTCGGCCTCCCCG
GTCACTGACAACTTCAGGAGGGTCGTGGATGGGTGTGAGATGGCCCTGCCCGGTTTGGCCACCCAGAGCCCCGTGCATCCCAACAAAAGC
GTCAAGTCCAGCAGCCTTCCCAGGGCCTTTCAGAAGGCCAGCCGGCAGGAGGAGCCGGACAGCCTCTCCTATTACTGCGCTGCTGAGACC
AACGGGGTGGGTGCAGCCTCGGGCACCCCGCCCTCCAAGGCTACCCTGGAGGGGAAGGTGGCTTCCCCCAAGCACTGTGTTCTGGCTCGG
CCCAAAGGGACTCCCCCTCTGCCCCCTGTCCGAAAGTCCAGCCTGGACCAGAAGAACCGGGCCAGCCCTCAGCACAGTGCCAGCGGCAGC
GGCACCAGCAGCCCCCTGAACCAACCAGCCGCCTTCCCGGCGGGCCTCCCAGACGAGCCTAGCGGCAAGACGAAGGACGCCAGCAGCAGC
AGCAAGCTCTTCAGTGCCAAGCTGGAGCAGCTGGCCAGCAGAAGCAACTCGCTGGGCAGGGCGACAGTCAGCCACTACGAATGCCTCTCC
CTGGAGCGGGCCGAGAGCCTGTCCTCCGTGAGCTCCCGGCTGCACGCGGGCAAGGACGGCACCATGCCCCGCGCGGGGAGGAGCCTGGGC
CGCAGCGCCGGGACCTCGCCCCCCAGCTCCGGGGCCTCGCCCAAGGCCGGCCAGTCCAAGATCTCCGCCGTGAGCAGACTCCTCCTGGCC
AGCCCCAGAGCGCGCGGCCCGTCCGCCTCCACCACCAAAACCCTCAGCTTCTCCACCAAGTCCCTGCCGCAGGCGGTGGGCCAGGGCTCC
AGCTCGCCCCCCGGTGGGAAGCACACGCCCTGGTCCACGCAGTCCCTCAGCAGGAACAGGAGCTCGGGCCTGGCCTCCAAGCTTCCCCTG
CGGGCCGTCAGCGGGCGCATCTCGGAGCTGCTGCAGGGTGGCGCGGGCGCCCGGGGCTTGCAGCTGCGGGCCGGGCCCGAGGCGGAGGCG
CGCGGGGGGGCCCTGGCCGAGGACGAGCCCGCGGCCGCGCACCTGCTCCCGTCGCCCTACAGCAAGATCACGCCCCCGCGGAGGCCCCAC
CGCTGCAGCAGCGGCCACGGCAGCGACAACAGCAGCGTGCTGAGCGGGGAGCTCCCGCCGGCCATGGGGAAGACGGCCCTGTTCTACCAC
AGCGGCGGCAGCAGCGGCTACGAGAGCGTGATGCGGGACAGCGAGGCCACCGGCAGCGCGTCCTCGGCGCAGGACTCCACGAGCGAGAAC
AGCAGCTCCGTGGGCGGCAGGTGCCGGAGCCTCAAGACCCCGAAGAAACGCTCCAATCCAGGTTCTCAGAGACGGAGGCTTATCCCAGCA
CTATCCCTGGACACCTCTTCCCCTGTGAGAAAACCCCCCAACAGCACAGGCGTCCGCTGGGTGGATGGCCCCTTGCGGAGCAGCCCGAGG
GGCCTTGGGGAACCCTTTGAGATTAAAGTCTATGAAATCGATGACGTGGAGCGCCTGCAGCGGCGACGAGGGGGTGCCAGCAAGGAGGCC
ATGTGCTTCAATGCAAAGCTGAAGATTCTGGAACACCGCCAGCAGAGGATCGCCGAGGTCCGCGCGAAGTACGAGTGGCTGATGAAGGAG
CTGGAGGCGACCAAACAGTATCTGATGCTGGATCCCAACAAGTGGCTCAGTGAATTTGACTTGGAGCAGGTTTGGGAGCTGGATTCCCTG
GAGTACCTGGAGGCACTGGAGTGTGTGACGGAGCGCCTGGAGAGCCGTGTCAACTTCTGCAAGGCCCATCTCATGATGATCACCTGCTTC
GACATCACCTCCAGGCGCCGGTAGATGAGCCAGACCCTTGTCCTAGTGGTCCCCCGCTCCCCAGGACTTCAGAGATGTTGCACGCCCCTA
GGCCCTCTGTGCTGGGGCATCAAAGACAATGAATGAGGATGAAGGTTGGTGGCAAGTCTGGAGCGGGCGTTGAGCGGAAGGCGAGTTTTC
TTTTGTTTTCTGTAGGAAAGGTGCAAACGTCAAACACCGTGGAAGGAGAAAAGGATGGGAAGCCCGAGGGGTGTCCAAGCCCTGTGAGAC
TGAAAAAGCACTTTGAGGAACCTTAAAGACCTTGTTTGTACATAAGAACTGCTAGCAAAAGAGACCTCACTCTTCTCTTGCTTTCGTGAG
AAAGGAGGGGCGTGGATGTAGGATTGCTGTGGAAAGCGAACACAAAACAACCCAGAATGACTGATTAAGTGCCTTGCAAATCTTTATTAT
TATCCAAACATTTATGTTCATACTTTCTTGTGTACAGATGGTGCTAGTCAAGATGAAAACAACAAAACAAACAAGAAAAACATTTTGGAA
ATGT

>25298_25298_1_EFCAB2-KIF26B_EFCAB2_chr1_245133745_ENST00000366522_KIF26B_chr1_245530136_ENST00000407071_length(amino acids)=2060AA_BP=0
MLGPGQVRLRPRVWRDKAGGRVADGASGLPPARGSWRETGTGRALGASSPPRPAQGSSSPGIQSGPSSRPGSPRGAEQAGTPRPRLSLGI
SQATGSAARWRTRRTGKDPAFSAVIHDKLQVPNTIRKAWNDRDNRCDICATHLNQLKQEAIQMVLTLEQAAGSEHYDASPCSPPPLSNIP
TLVGSRHVGGLQQPRDWAFVPAPCATSNYTGFANKHGSKPSSLGVSNGAEKKSGSPTHQAKVSLQMATSPSNGNILNSVAIQAHQYLDGT
WSLSRTNGVTLYPYQISQLMTESSREGLTEAVLNRYNADKPSACSVPASQGSCVASETSTGTSVAASFFARAAQKLNLSSKKKKHRPSTS
SAAEPPLFATSFSGILQTSPPPAPPCLLRAVNKVKDTPGLGKVKVMLRICSTLARDTSESSSFLKVDPRKKQITLYDPLTCGGQNAFQKR
GNQVPPKMFAFDAVFPQDASQAEVCAGTVAEVIQSVVNGADGCVFCFGHAKLGKSYTMIGKDDSMQNLGIIPCAISWLFKLINERKEKTG
ARFSVRVSAVEVWGKEENLRDLLSEVATGSLQDGQSPGVYLCEDPICGTQLQNQSELRAPTAEKAAFFLDAAIASRRSHQQDCDEDDHRN
SHVFFTLHIYQYRMEKSGKGGMSGGRSRLHLIDLGSCVKALSKNREGGSGLCLSLSALGNVILALVNGSKHIPYKESKLAMLLRESLGNM
NCRTTMIAHISAAVGSYAETLSTIQIASRVLRMKKKKTKYTSSSSGGESSCEEGRMRRPTQLRPFHTRATVDPDFPIAHLSSDPDYSSSS
EQSCDTVIYIGPNGTALSDKELTDNEGPPDFVPIVPALQKTRGDSRPAEAGEAAAGKSERDCLKCNTFAELQERLDCIDGSEEPSSFPFE
ELPAQFGPEQASRGPRLSQAAGASPLSESDKEDNGSEGQLTNREGPELPASKMQRSHSPVPAAAPAHSPSPASPRSVPGSSSQHSASPLV
QSPSLQSSRESLNSCGFVEGKPRPMGSPRLGIASLSKTSEYKPPSSPSQRCKVYTQKGVLPSPAPLPPSSKDSGVASRESLLQPEVRTPP
VGMSPQVLKKSMSAGSEGFPETPVDDEQQAATPSESKKEILSTTMVTVQQPLELNGEDELVFTLVEELTISGVLDSGRPTSIISFNSDCS
ARALASGSRPVSIISSISEDLECYSSTAPVSEVSITQFLPLPKMSLDEKAQDAGSRRSSISSWLSEMSAGSEGEQSCHSFIAQTCFGHGE
AMAEPVASEFVSSLQNTAVVCREKPKASPDNLLILSEMGDDSFNKAAPIKGCKISTVSKAMVTISNTANLSSCEGYIPMKTNITVYPCIA
MSPRNIQEPEAPTATPKAGPTLAQSRESKENSAKKEMKFEDPWLKREEEVKKETAHPNEEGMMRCETATGPSNAETRAEQEQDGKPSPGD
RLSSSSGEVSASPVTDNFRRVVDGCEMALPGLATQSPVHPNKSVKSSSLPRAFQKASRQEEPDSLSYYCAAETNGVGAASGTPPSKATLE
GKVASPKHCVLARPKGTPPLPPVRKSSLDQKNRASPQHSASGSGTSSPLNQPAAFPAGLPDEPSGKTKDASSSSKLFSAKLEQLASRSNS
LGRATVSHYECLSLERAESLSSVSSRLHAGKDGTMPRAGRSLGRSAGTSPPSSGASPKAGQSKISAVSRLLLASPRARGPSASTTKTLSF
STKSLPQAVGQGSSSPPGGKHTPWSTQSLSRNRSSGLASKLPLRAVSGRISELLQGGAGARGLQLRAGPEAEARGGALAEDEPAAAHLLP
SPYSKITPPRRPHRCSSGHGSDNSSVLSGELPPAMGKTALFYHSGGSSGYESVMRDSEATGSASSAQDSTSENSSSVGGRCRSLKTPKKR
SNPGSQRRRLIPALSLDTSSPVRKPPNSTGVRWVDGPLRSSPRGLGEPFEIKVYEIDDVERLQRRRGGASKEAMCFNAKLKILEHRQQRI
AEVRAKYEWLMKELEATKQYLMLDPNKWLSEFDLEQVWELDSLEYLEALECVTERLESRVNFCKAHLMMITCFDITSRRR

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Fusion Gene PPI Analysis for EFCAB2-KIF26B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EFCAB2-KIF26B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EFCAB2-KIF26B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource