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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FAM213A-JCHAIN (FusionGDB2 ID:HG84293TG3512)

Fusion Gene Summary for FAM213A-JCHAIN

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM213A-JCHAIN
Fusion gene ID: hg84293tg3512
HgeneTgene
Gene symbol

FAM213A

JCHAIN

Gene ID

84293

3512

Gene nameperoxiredoxin like 2Ajoining chain of multimeric IgA and IgM
SynonymsAdrx|C10orf58|FAM213A|PAMMIGCJ|IGJ|JCH
Cytomap('FAM213A','FAM213A')('IGJ','JCHAIN')

10q23.1

4q13.3

Type of geneprotein-codingprotein-coding
Descriptionperoxiredoxin-like 2AAdiporedoxinUPF0765 protein C10orf58family with sequence similarity 213 member Aperoxiredoxin (PRX)-like 2 activated in M-CSF stimulated monocytesperoxiredoxin-like 2 activated in M-CSF stimulated monocytesredox-regulatory proteimmunoglobulin J chainIgJ chainJ chainimmunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000372181, ENST00000372185, 
ENST00000372187, ENST00000372188, 
Fusion gene scores* DoF score8 X 9 X 5=3605 X 4 X 3=60
# samples 95
** MAII scorelog2(9/360*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM213A [Title/Abstract] AND JCHAIN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFAM213A(82180401)-IGJ(71527932), # samples:1
FAM213A(82180401)-JCHAIN(71527932), # samples:1
Anticipated loss of major functional domain due to fusion event.FAM213A-IGJ seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FAM213A-IGJ seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFAM213A

GO:0045670

regulation of osteoclast differentiation

19951071

HgeneFAM213A

GO:0055114

oxidation-reduction process

19951071

TgeneJCHAIN

GO:0002250

adaptive immune response

21786026

TgeneJCHAIN

GO:0019731

antibacterial humoral response

23250751

TgeneJCHAIN

GO:0045087

innate immune response

21786026

TgeneJCHAIN

GO:0060267

positive regulation of respiratory burst

24145934


check buttonFusion gene breakpoints across FAM213A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across JCHAIN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AQ-A04L-01BFAM213Achr10

82180401

+IGJchr4

71527932

-
ChimerDB4BRCATCGA-AQ-A04L-01BFAM213Achr10

82180401

+JCHAINchr4

71527932

-


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Fusion Gene ORF analysis for FAM213A-JCHAIN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000372181ENST00000254801FAM213Achr10

82180401

+IGJchr4

71527932

-
In-frameENST00000372181ENST00000543780FAM213Achr10

82180401

+IGJchr4

71527932

-
In-frameENST00000372185ENST00000254801FAM213Achr10

82180401

+IGJchr4

71527932

-
In-frameENST00000372185ENST00000543780FAM213Achr10

82180401

+IGJchr4

71527932

-
In-frameENST00000372187ENST00000254801FAM213Achr10

82180401

+IGJchr4

71527932

-
In-frameENST00000372187ENST00000543780FAM213Achr10

82180401

+IGJchr4

71527932

-
In-frameENST00000372188ENST00000254801FAM213Achr10

82180401

+IGJchr4

71527932

-
In-frameENST00000372188ENST00000543780FAM213Achr10

82180401

+IGJchr4

71527932

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000372188FAM213Achr1082180401+ENST00000254801IGJchr471527932-1512308130723197
ENST00000372188FAM213Achr1082180401+ENST00000543780IGJchr471527932-724308130723198
ENST00000372187FAM213Achr1082180401+ENST00000254801IGJchr471527932-1535331153746197
ENST00000372187FAM213Achr1082180401+ENST00000543780IGJchr471527932-747331153746197
ENST00000372185FAM213Achr1082180401+ENST00000254801IGJchr471527932-1517313168728186
ENST00000372185FAM213Achr1082180401+ENST00000543780IGJchr471527932-729313168728186
ENST00000372181FAM213Achr1082180401+ENST00000254801IGJchr471527932-18526484701063197
ENST00000372181FAM213Achr1082180401+ENST00000543780IGJchr471527932-10646484701063198

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000372188ENST00000254801FAM213Achr1082180401+IGJchr471527932-0.0008616650.99913836
ENST00000372188ENST00000543780FAM213Achr1082180401+IGJchr471527932-0.0050338970.9949661
ENST00000372187ENST00000254801FAM213Achr1082180401+IGJchr471527932-0.0007160470.99928397
ENST00000372187ENST00000543780FAM213Achr1082180401+IGJchr471527932-0.0019359930.998064
ENST00000372185ENST00000254801FAM213Achr1082180401+IGJchr471527932-0.0007794210.9992206
ENST00000372185ENST00000543780FAM213Achr1082180401+IGJchr471527932-0.0021001210.9978999
ENST00000372181ENST00000254801FAM213Achr1082180401+IGJchr471527932-0.0012239550.998776
ENST00000372181ENST00000543780FAM213Achr1082180401+IGJchr471527932-0.0042384730.9957616

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Fusion Genomic Features for FAM213A-JCHAIN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for FAM213A-JCHAIN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:82180401/:71527932)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAM213Achr10:82180401chr4:71527932ENST00000372181+1514_11259230.0RegionThioredoxin fold
HgeneFAM213Achr10:82180401chr4:71527932ENST00000372185+2614_11248219.0RegionThioredoxin fold
HgeneFAM213Achr10:82180401chr4:71527932ENST00000372187+2614_11259230.0RegionThioredoxin fold
HgeneFAM213Achr10:82180401chr4:71527932ENST00000372188+2614_11259230.0RegionThioredoxin fold


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Fusion Gene Sequence for FAM213A-JCHAIN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>28906_28906_1_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372181_IGJ_chr4_71527932_ENST00000254801_length(transcript)=1852nt_BP=648nt
AGTATCCTCTGATCACAGAAGAGAAAGCTGCCCCTACCCAGGGACATGATCCTGAGCCACCTGGATTGTGAGGGAGAATCAGGCATTGAT
GAGGAGGGGAATGAGGAAGTAGTCTGCCTACAGGGGACATAGCTCGGCACAGCTCCACAGAGCTAGGGGCTGCAACTTGGGGCATGAGAA
GAGAGAGCAGCAAGAGAACCATTTGAGAAGGCTGTCCTTTCTCTGTCATCACTCCTGATGCCCTGGTGAGCTCCACGGTGCAGGAACCTC
CATGTGTGTGCTGCATCCCCAAGTTCTGGTGGCAGCAGGTGCTTAGCAGCCCTTGTCCAGTCTCGCCTGTGACACTGCTGCTCCCTTCCC
CTGTCCTGACCTCCTGGTTGGCTGTCCTGCCAGAGCCTTGCCTGGAAGATGAAATTCCAGCTACCCTGTGGGAGCAGTAACGCCTTCTTC
CTTCTTCTCAATCTCCAGAAATGTCTTTCCTCCAGGACCCAAGTTTCTTCACCATGGGGATGTGGTCCATTGGTGCAGGAGCCCTGGGGG
CTGCTGCCTTGGCATTGCTGCTTGCCAACACAGACGTGTTTCTGTCCAAGCCCCAGAAAGCGGCCCTGGAGTACCTGGAGGATATAGACC
TGAAAACACTGGAGAAGGCCCAAGAAGATGAAAGGATTGTTCTTGTTGACAACAAATGTAAGTGTGCCCGGATTACTTCCAGGATCATCC
GTTCTTCCGAAGATCCTAATGAGGACATTGTGGAGAGAAACATCCGAATTATTGTTCCTCTGAACAACAGGGAGAATATCTCTGATCCCA
CCTCACCATTGAGAACCAGATTTGTGTACCATTTGTCTGACCTCTGTAAAAAATGTGATCCTACAGAAGTGGAGCTGGATAATCAGATAG
TTACTGCTACCCAGAGCAATATCTGTGATGAAGACAGTGCTACAGAGACCTGCTACACTTATGACAGAAACAAGTGCTACACAGCTGTGG
TCCCACTCGTATATGGTGGTGAGACCAAAATGGTGGAAACAGCCTTAACCCCAGATGCCTGCTATCCTGACTAATTTAAGTCATTGCTGA
CTGCATAGCTCTTTTTCTTGAGAGGCTCTCCATTTTGATTCAGAAAGTTAGCATATTTATTACCAATGAATTTGAAACCAGGGCTTTTTT
TTTTTTTTGGGTGATGTAAAACCAACTCCCTGCCACCAAAATAATTAAAATAGTCACATTGTTATCTTTATTAGGTAATCACTTCTTAAT
TATATGTTCATACTCTAAGTATCAAAATCTTCCAATTATCATGCTCACCTGAAAGAGGTATGCTCTCTTAGGAATACAGTTTCTAGCATT
AAACAAATAAACAAGGGGAGAAAATAAAACTCAAGGACTGAAAATCAGGAGGTGTAATAAAATGTTCCTCGCATTCCCCCCCGCTTTTTT
TTTTTTTTTTGACTTTGCCTTGGAGAGCCAGAGCTTCCGCATTTTCTTTACTATTCTTTTTAAAAAAAGTTTCACTGTGTAGAGAACATA
TATGCATAAACATAGGTCAATTATATGTCTCCATTAGAAAAATAATAATTGGAAAACATGTTCTAGAACTAGTTACAAAAATAATTTAAG
GTGAAATCTCTAATATTTATAAAAGTAGCAAAATAAATGCATAATTAAAATATATTTGGACATAACAGACTTGGAAGCAGATGATACAGA
CTTCTTTTTTTCATAATCAGGTTAGTGTAAGAAATTGCCATTTGAAACAATCCATTTTGTAACTGAACCTTATGAAATATATGTATTTCA

>28906_28906_1_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372181_IGJ_chr4_71527932_ENST00000254801_length(amino acids)=197AA_BP=59
MSFLQDPSFFTMGMWSIGAGALGAAALALLLANTDVFLSKPQKAALEYLEDIDLKTLEKAQEDERIVLVDNKCKCARITSRIIRSSEDPN
EDIVERNIRIIVPLNNRENISDPTSPLRTRFVYHLSDLCKKCDPTEVELDNQIVTATQSNICDEDSATETCYTYDRNKCYTAVVPLVYGG

--------------------------------------------------------------
>28906_28906_2_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372181_IGJ_chr4_71527932_ENST00000543780_length(transcript)=1064nt_BP=648nt
AGTATCCTCTGATCACAGAAGAGAAAGCTGCCCCTACCCAGGGACATGATCCTGAGCCACCTGGATTGTGAGGGAGAATCAGGCATTGAT
GAGGAGGGGAATGAGGAAGTAGTCTGCCTACAGGGGACATAGCTCGGCACAGCTCCACAGAGCTAGGGGCTGCAACTTGGGGCATGAGAA
GAGAGAGCAGCAAGAGAACCATTTGAGAAGGCTGTCCTTTCTCTGTCATCACTCCTGATGCCCTGGTGAGCTCCACGGTGCAGGAACCTC
CATGTGTGTGCTGCATCCCCAAGTTCTGGTGGCAGCAGGTGCTTAGCAGCCCTTGTCCAGTCTCGCCTGTGACACTGCTGCTCCCTTCCC
CTGTCCTGACCTCCTGGTTGGCTGTCCTGCCAGAGCCTTGCCTGGAAGATGAAATTCCAGCTACCCTGTGGGAGCAGTAACGCCTTCTTC
CTTCTTCTCAATCTCCAGAAATGTCTTTCCTCCAGGACCCAAGTTTCTTCACCATGGGGATGTGGTCCATTGGTGCAGGAGCCCTGGGGG
CTGCTGCCTTGGCATTGCTGCTTGCCAACACAGACGTGTTTCTGTCCAAGCCCCAGAAAGCGGCCCTGGAGTACCTGGAGGATATAGACC
TGAAAACACTGGAGAAGGCCCAAGAAGATGAAAGGATTGTTCTTGTTGACAACAAATGTAAGTGTGCCCGGATTACTTCCAGGATCATCC
GTTCTTCCGAAGATCCTAATGAGGACATTGTGGAGAGAAACATCCGAATTATTGTTCCTCTGAACAACAGGGAGAATATCTCTGATCCCA
CCTCACCATTGAGAACCAGATTTGTGTACCATTTGTCTGACCTCTGTAAAAAATGTGATCCTACAGAAGTGGAGCTGGATAATCAGATAG
TTACTGCTACCCAGAGCAATATCTGTGATGAAGACAGTGCTACAGAGACCTGCTACACTTATGACAGAAACAAGTGCTACACAGCTGTGG

>28906_28906_2_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372181_IGJ_chr4_71527932_ENST00000543780_length(amino acids)=198AA_BP=59
MSFLQDPSFFTMGMWSIGAGALGAAALALLLANTDVFLSKPQKAALEYLEDIDLKTLEKAQEDERIVLVDNKCKCARITSRIIRSSEDPN
EDIVERNIRIIVPLNNRENISDPTSPLRTRFVYHLSDLCKKCDPTEVELDNQIVTATQSNICDEDSATETCYTYDRNKCYTAVVPLVYGG

--------------------------------------------------------------
>28906_28906_3_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372185_IGJ_chr4_71527932_ENST00000254801_length(transcript)=1517nt_BP=313nt
TGGCGGTGGCGCGGTAGCGCGCGATGCAGCACAGGCTAGAGGCTGCGCAAGCGCGGGGCCCGCCCCTGGGACCCTCCGGGCCGGGCGGTT
TGGCCCCTTAGCGCCCGGGCGTCGGGGCGGTAAAAGGCCGGCAGAAGGGAGGCACTTGAGGACCCAAGTTTCTTCACCATGGGGATGTGG
TCCATTGGTGCAGGAGCCCTGGGGGCTGCTGCCTTGGCATTGCTGCTTGCCAACACAGACGTGTTTCTGTCCAAGCCCCAGAAAGCGGCC
CTGGAGTACCTGGAGGATATAGACCTGAAAACACTGGAGAAGGCCCAAGAAGATGAAAGGATTGTTCTTGTTGACAACAAATGTAAGTGT
GCCCGGATTACTTCCAGGATCATCCGTTCTTCCGAAGATCCTAATGAGGACATTGTGGAGAGAAACATCCGAATTATTGTTCCTCTGAAC
AACAGGGAGAATATCTCTGATCCCACCTCACCATTGAGAACCAGATTTGTGTACCATTTGTCTGACCTCTGTAAAAAATGTGATCCTACA
GAAGTGGAGCTGGATAATCAGATAGTTACTGCTACCCAGAGCAATATCTGTGATGAAGACAGTGCTACAGAGACCTGCTACACTTATGAC
AGAAACAAGTGCTACACAGCTGTGGTCCCACTCGTATATGGTGGTGAGACCAAAATGGTGGAAACAGCCTTAACCCCAGATGCCTGCTAT
CCTGACTAATTTAAGTCATTGCTGACTGCATAGCTCTTTTTCTTGAGAGGCTCTCCATTTTGATTCAGAAAGTTAGCATATTTATTACCA
ATGAATTTGAAACCAGGGCTTTTTTTTTTTTTTGGGTGATGTAAAACCAACTCCCTGCCACCAAAATAATTAAAATAGTCACATTGTTAT
CTTTATTAGGTAATCACTTCTTAATTATATGTTCATACTCTAAGTATCAAAATCTTCCAATTATCATGCTCACCTGAAAGAGGTATGCTC
TCTTAGGAATACAGTTTCTAGCATTAAACAAATAAACAAGGGGAGAAAATAAAACTCAAGGACTGAAAATCAGGAGGTGTAATAAAATGT
TCCTCGCATTCCCCCCCGCTTTTTTTTTTTTTTTTGACTTTGCCTTGGAGAGCCAGAGCTTCCGCATTTTCTTTACTATTCTTTTTAAAA
AAAGTTTCACTGTGTAGAGAACATATATGCATAAACATAGGTCAATTATATGTCTCCATTAGAAAAATAATAATTGGAAAACATGTTCTA
GAACTAGTTACAAAAATAATTTAAGGTGAAATCTCTAATATTTATAAAAGTAGCAAAATAAATGCATAATTAAAATATATTTGGACATAA
CAGACTTGGAAGCAGATGATACAGACTTCTTTTTTTCATAATCAGGTTAGTGTAAGAAATTGCCATTTGAAACAATCCATTTTGTAACTG

>28906_28906_3_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372185_IGJ_chr4_71527932_ENST00000254801_length(amino acids)=186AA_BP=48
MGMWSIGAGALGAAALALLLANTDVFLSKPQKAALEYLEDIDLKTLEKAQEDERIVLVDNKCKCARITSRIIRSSEDPNEDIVERNIRII
VPLNNRENISDPTSPLRTRFVYHLSDLCKKCDPTEVELDNQIVTATQSNICDEDSATETCYTYDRNKCYTAVVPLVYGGETKMVETALTP

--------------------------------------------------------------
>28906_28906_4_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372185_IGJ_chr4_71527932_ENST00000543780_length(transcript)=729nt_BP=313nt
TGGCGGTGGCGCGGTAGCGCGCGATGCAGCACAGGCTAGAGGCTGCGCAAGCGCGGGGCCCGCCCCTGGGACCCTCCGGGCCGGGCGGTT
TGGCCCCTTAGCGCCCGGGCGTCGGGGCGGTAAAAGGCCGGCAGAAGGGAGGCACTTGAGGACCCAAGTTTCTTCACCATGGGGATGTGG
TCCATTGGTGCAGGAGCCCTGGGGGCTGCTGCCTTGGCATTGCTGCTTGCCAACACAGACGTGTTTCTGTCCAAGCCCCAGAAAGCGGCC
CTGGAGTACCTGGAGGATATAGACCTGAAAACACTGGAGAAGGCCCAAGAAGATGAAAGGATTGTTCTTGTTGACAACAAATGTAAGTGT
GCCCGGATTACTTCCAGGATCATCCGTTCTTCCGAAGATCCTAATGAGGACATTGTGGAGAGAAACATCCGAATTATTGTTCCTCTGAAC
AACAGGGAGAATATCTCTGATCCCACCTCACCATTGAGAACCAGATTTGTGTACCATTTGTCTGACCTCTGTAAAAAATGTGATCCTACA
GAAGTGGAGCTGGATAATCAGATAGTTACTGCTACCCAGAGCAATATCTGTGATGAAGACAGTGCTACAGAGACCTGCTACACTTATGAC
AGAAACAAGTGCTACACAGCTGTGGTCCCACTCGTATATGGTGGTGAGACCAAAATGGTGGAAACAGCCTTAACCCCAGATGCCTGCTAT

>28906_28906_4_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372185_IGJ_chr4_71527932_ENST00000543780_length(amino acids)=186AA_BP=48
MGMWSIGAGALGAAALALLLANTDVFLSKPQKAALEYLEDIDLKTLEKAQEDERIVLVDNKCKCARITSRIIRSSEDPNEDIVERNIRII
VPLNNRENISDPTSPLRTRFVYHLSDLCKKCDPTEVELDNQIVTATQSNICDEDSATETCYTYDRNKCYTAVVPLVYGGETKMVETALTP

--------------------------------------------------------------
>28906_28906_5_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372187_IGJ_chr4_71527932_ENST00000254801_length(transcript)=1535nt_BP=331nt
ATGGCGGTGGCGCGGTAGCGCGCGATGCAGCACAGGCTAGAGGCTGCGCAAGCGCGGGGCCCGCCCCTGGGACCCTCCGGGCCGGGCGGT
TTGGCCCCTTAGCGCCCGGGCGTCGGGGCGGTAAAAGGCCGGCAGAAGGGAGGCACTTGAGAAATGTCTTTCCTCCAGGACCCAAGTTTC
TTCACCATGGGGATGTGGTCCATTGGTGCAGGAGCCCTGGGGGCTGCTGCCTTGGCATTGCTGCTTGCCAACACAGACGTGTTTCTGTCC
AAGCCCCAGAAAGCGGCCCTGGAGTACCTGGAGGATATAGACCTGAAAACACTGGAGAAGGCCCAAGAAGATGAAAGGATTGTTCTTGTT
GACAACAAATGTAAGTGTGCCCGGATTACTTCCAGGATCATCCGTTCTTCCGAAGATCCTAATGAGGACATTGTGGAGAGAAACATCCGA
ATTATTGTTCCTCTGAACAACAGGGAGAATATCTCTGATCCCACCTCACCATTGAGAACCAGATTTGTGTACCATTTGTCTGACCTCTGT
AAAAAATGTGATCCTACAGAAGTGGAGCTGGATAATCAGATAGTTACTGCTACCCAGAGCAATATCTGTGATGAAGACAGTGCTACAGAG
ACCTGCTACACTTATGACAGAAACAAGTGCTACACAGCTGTGGTCCCACTCGTATATGGTGGTGAGACCAAAATGGTGGAAACAGCCTTA
ACCCCAGATGCCTGCTATCCTGACTAATTTAAGTCATTGCTGACTGCATAGCTCTTTTTCTTGAGAGGCTCTCCATTTTGATTCAGAAAG
TTAGCATATTTATTACCAATGAATTTGAAACCAGGGCTTTTTTTTTTTTTTGGGTGATGTAAAACCAACTCCCTGCCACCAAAATAATTA
AAATAGTCACATTGTTATCTTTATTAGGTAATCACTTCTTAATTATATGTTCATACTCTAAGTATCAAAATCTTCCAATTATCATGCTCA
CCTGAAAGAGGTATGCTCTCTTAGGAATACAGTTTCTAGCATTAAACAAATAAACAAGGGGAGAAAATAAAACTCAAGGACTGAAAATCA
GGAGGTGTAATAAAATGTTCCTCGCATTCCCCCCCGCTTTTTTTTTTTTTTTTGACTTTGCCTTGGAGAGCCAGAGCTTCCGCATTTTCT
TTACTATTCTTTTTAAAAAAAGTTTCACTGTGTAGAGAACATATATGCATAAACATAGGTCAATTATATGTCTCCATTAGAAAAATAATA
ATTGGAAAACATGTTCTAGAACTAGTTACAAAAATAATTTAAGGTGAAATCTCTAATATTTATAAAAGTAGCAAAATAAATGCATAATTA
AAATATATTTGGACATAACAGACTTGGAAGCAGATGATACAGACTTCTTTTTTTCATAATCAGGTTAGTGTAAGAAATTGCCATTTGAAA
CAATCCATTTTGTAACTGAACCTTATGAAATATATGTATTTCATGGTACGTATTCTCTAGCACAGTCTGAGCAATTAAATAGATTCATAA

>28906_28906_5_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372187_IGJ_chr4_71527932_ENST00000254801_length(amino acids)=197AA_BP=59
MSFLQDPSFFTMGMWSIGAGALGAAALALLLANTDVFLSKPQKAALEYLEDIDLKTLEKAQEDERIVLVDNKCKCARITSRIIRSSEDPN
EDIVERNIRIIVPLNNRENISDPTSPLRTRFVYHLSDLCKKCDPTEVELDNQIVTATQSNICDEDSATETCYTYDRNKCYTAVVPLVYGG

--------------------------------------------------------------
>28906_28906_6_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372187_IGJ_chr4_71527932_ENST00000543780_length(transcript)=747nt_BP=331nt
ATGGCGGTGGCGCGGTAGCGCGCGATGCAGCACAGGCTAGAGGCTGCGCAAGCGCGGGGCCCGCCCCTGGGACCCTCCGGGCCGGGCGGT
TTGGCCCCTTAGCGCCCGGGCGTCGGGGCGGTAAAAGGCCGGCAGAAGGGAGGCACTTGAGAAATGTCTTTCCTCCAGGACCCAAGTTTC
TTCACCATGGGGATGTGGTCCATTGGTGCAGGAGCCCTGGGGGCTGCTGCCTTGGCATTGCTGCTTGCCAACACAGACGTGTTTCTGTCC
AAGCCCCAGAAAGCGGCCCTGGAGTACCTGGAGGATATAGACCTGAAAACACTGGAGAAGGCCCAAGAAGATGAAAGGATTGTTCTTGTT
GACAACAAATGTAAGTGTGCCCGGATTACTTCCAGGATCATCCGTTCTTCCGAAGATCCTAATGAGGACATTGTGGAGAGAAACATCCGA
ATTATTGTTCCTCTGAACAACAGGGAGAATATCTCTGATCCCACCTCACCATTGAGAACCAGATTTGTGTACCATTTGTCTGACCTCTGT
AAAAAATGTGATCCTACAGAAGTGGAGCTGGATAATCAGATAGTTACTGCTACCCAGAGCAATATCTGTGATGAAGACAGTGCTACAGAG
ACCTGCTACACTTATGACAGAAACAAGTGCTACACAGCTGTGGTCCCACTCGTATATGGTGGTGAGACCAAAATGGTGGAAACAGCCTTA

>28906_28906_6_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372187_IGJ_chr4_71527932_ENST00000543780_length(amino acids)=197AA_BP=59
MSFLQDPSFFTMGMWSIGAGALGAAALALLLANTDVFLSKPQKAALEYLEDIDLKTLEKAQEDERIVLVDNKCKCARITSRIIRSSEDPN
EDIVERNIRIIVPLNNRENISDPTSPLRTRFVYHLSDLCKKCDPTEVELDNQIVTATQSNICDEDSATETCYTYDRNKCYTAVVPLVYGG

--------------------------------------------------------------
>28906_28906_7_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372188_IGJ_chr4_71527932_ENST00000254801_length(transcript)=1512nt_BP=308nt
TGCCCAGACTGGTCTTGAACTCCTGGGCTCAAGCGATCCTCCCAAAGCCCTGAGATTACAGGCGTGAGCCAGCGCGCCGGACACAACCTC
CTACTTTCATGAAAGAGTGGGCACTTCCAACAGGAGGAAAATGTCTTTCCTCCAGGACCCAAGTTTCTTCACCATGGGGATGTGGTCCAT
TGGTGCAGGAGCCCTGGGGGCTGCTGCCTTGGCATTGCTGCTTGCCAACACAGACGTGTTTCTGTCCAAGCCCCAGAAAGCGGCCCTGGA
GTACCTGGAGGATATAGACCTGAAAACACTGGAGAAGGCCCAAGAAGATGAAAGGATTGTTCTTGTTGACAACAAATGTAAGTGTGCCCG
GATTACTTCCAGGATCATCCGTTCTTCCGAAGATCCTAATGAGGACATTGTGGAGAGAAACATCCGAATTATTGTTCCTCTGAACAACAG
GGAGAATATCTCTGATCCCACCTCACCATTGAGAACCAGATTTGTGTACCATTTGTCTGACCTCTGTAAAAAATGTGATCCTACAGAAGT
GGAGCTGGATAATCAGATAGTTACTGCTACCCAGAGCAATATCTGTGATGAAGACAGTGCTACAGAGACCTGCTACACTTATGACAGAAA
CAAGTGCTACACAGCTGTGGTCCCACTCGTATATGGTGGTGAGACCAAAATGGTGGAAACAGCCTTAACCCCAGATGCCTGCTATCCTGA
CTAATTTAAGTCATTGCTGACTGCATAGCTCTTTTTCTTGAGAGGCTCTCCATTTTGATTCAGAAAGTTAGCATATTTATTACCAATGAA
TTTGAAACCAGGGCTTTTTTTTTTTTTTGGGTGATGTAAAACCAACTCCCTGCCACCAAAATAATTAAAATAGTCACATTGTTATCTTTA
TTAGGTAATCACTTCTTAATTATATGTTCATACTCTAAGTATCAAAATCTTCCAATTATCATGCTCACCTGAAAGAGGTATGCTCTCTTA
GGAATACAGTTTCTAGCATTAAACAAATAAACAAGGGGAGAAAATAAAACTCAAGGACTGAAAATCAGGAGGTGTAATAAAATGTTCCTC
GCATTCCCCCCCGCTTTTTTTTTTTTTTTTGACTTTGCCTTGGAGAGCCAGAGCTTCCGCATTTTCTTTACTATTCTTTTTAAAAAAAGT
TTCACTGTGTAGAGAACATATATGCATAAACATAGGTCAATTATATGTCTCCATTAGAAAAATAATAATTGGAAAACATGTTCTAGAACT
AGTTACAAAAATAATTTAAGGTGAAATCTCTAATATTTATAAAAGTAGCAAAATAAATGCATAATTAAAATATATTTGGACATAACAGAC
TTGGAAGCAGATGATACAGACTTCTTTTTTTCATAATCAGGTTAGTGTAAGAAATTGCCATTTGAAACAATCCATTTTGTAACTGAACCT

>28906_28906_7_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372188_IGJ_chr4_71527932_ENST00000254801_length(amino acids)=197AA_BP=59
MSFLQDPSFFTMGMWSIGAGALGAAALALLLANTDVFLSKPQKAALEYLEDIDLKTLEKAQEDERIVLVDNKCKCARITSRIIRSSEDPN
EDIVERNIRIIVPLNNRENISDPTSPLRTRFVYHLSDLCKKCDPTEVELDNQIVTATQSNICDEDSATETCYTYDRNKCYTAVVPLVYGG

--------------------------------------------------------------
>28906_28906_8_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372188_IGJ_chr4_71527932_ENST00000543780_length(transcript)=724nt_BP=308nt
TGCCCAGACTGGTCTTGAACTCCTGGGCTCAAGCGATCCTCCCAAAGCCCTGAGATTACAGGCGTGAGCCAGCGCGCCGGACACAACCTC
CTACTTTCATGAAAGAGTGGGCACTTCCAACAGGAGGAAAATGTCTTTCCTCCAGGACCCAAGTTTCTTCACCATGGGGATGTGGTCCAT
TGGTGCAGGAGCCCTGGGGGCTGCTGCCTTGGCATTGCTGCTTGCCAACACAGACGTGTTTCTGTCCAAGCCCCAGAAAGCGGCCCTGGA
GTACCTGGAGGATATAGACCTGAAAACACTGGAGAAGGCCCAAGAAGATGAAAGGATTGTTCTTGTTGACAACAAATGTAAGTGTGCCCG
GATTACTTCCAGGATCATCCGTTCTTCCGAAGATCCTAATGAGGACATTGTGGAGAGAAACATCCGAATTATTGTTCCTCTGAACAACAG
GGAGAATATCTCTGATCCCACCTCACCATTGAGAACCAGATTTGTGTACCATTTGTCTGACCTCTGTAAAAAATGTGATCCTACAGAAGT
GGAGCTGGATAATCAGATAGTTACTGCTACCCAGAGCAATATCTGTGATGAAGACAGTGCTACAGAGACCTGCTACACTTATGACAGAAA
CAAGTGCTACACAGCTGTGGTCCCACTCGTATATGGTGGTGAGACCAAAATGGTGGAAACAGCCTTAACCCCAGATGCCTGCTATCCTGA

>28906_28906_8_FAM213A-IGJ_FAM213A_chr10_82180401_ENST00000372188_IGJ_chr4_71527932_ENST00000543780_length(amino acids)=198AA_BP=59
MSFLQDPSFFTMGMWSIGAGALGAAALALLLANTDVFLSKPQKAALEYLEDIDLKTLEKAQEDERIVLVDNKCKCARITSRIIRSSEDPN
EDIVERNIRIIVPLNNRENISDPTSPLRTRFVYHLSDLCKKCDPTEVELDNQIVTATQSNICDEDSATETCYTYDRNKCYTAVVPLVYGG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FAM213A-JCHAIN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FAM213A-JCHAIN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FAM213A-JCHAIN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource