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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ACBD6-IVNS1ABP (FusionGDB2 ID:HG84320TG10625) |
Fusion Gene Summary for ACBD6-IVNS1ABP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ACBD6-IVNS1ABP | Fusion gene ID: hg84320tg10625 | Hgene | Tgene | Gene symbol | ACBD6 | IVNS1ABP | Gene ID | 84320 | 10625 |
| Gene name | acyl-CoA binding domain containing 6 | influenza virus NS1A binding protein | |
| Synonyms | - | ARA3|FLARA3|HSPC068|KLHL39|ND1|NS-1|NS1-BP|NS1BP | |
| Cytomap | ('ACBD6')('IVNS1ABP') 1q25.2-q25.3 | 1q25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | acyl-CoA-binding domain-containing protein 6acyl-Coenzyme A binding domain containing 6 | influenza virus NS1A-binding proteinNCX downstream gene 1NS1-binding proteinaryl hydrocarbon receptor-associated 3aryl hydrocarbon receptor-associated protein 3kelch-like family member 39kelch-like protein 39 | |
| Modification date | 20200313 | 20200320 | |
| UniProtAcc | Q9BR61 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000367595, ENST00000475338, | ||
| Fusion gene scores | * DoF score | 11 X 9 X 7=693 | 17 X 9 X 9=1377 |
| # samples | 11 | 18 | |
| ** MAII score | log2(11/693*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(18/1377*10)=-2.93545974780529 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ACBD6 [Title/Abstract] AND IVNS1ABP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ACBD6(180366651)-IVNS1ABP(185274775), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | ACBD6-IVNS1ABP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ACBD6-IVNS1ABP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ACBD6-IVNS1ABP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ACBD6-IVNS1ABP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across ACBD6 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across IVNS1ABP (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-A2-A1FW-01A | ACBD6 | chr1 | 180366651 | - | IVNS1ABP | chr1 | 185274775 | - |
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Fusion Gene ORF analysis for ACBD6-IVNS1ABP |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000367595 | ENST00000392007 | ACBD6 | chr1 | 180366651 | - | IVNS1ABP | chr1 | 185274775 | - |
| 5CDS-5UTR | ENST00000367595 | ENST00000459929 | ACBD6 | chr1 | 180366651 | - | IVNS1ABP | chr1 | 185274775 | - |
| 5CDS-intron | ENST00000367595 | ENST00000367497 | ACBD6 | chr1 | 180366651 | - | IVNS1ABP | chr1 | 185274775 | - |
| 5UTR-3CDS | ENST00000475338 | ENST00000367498 | ACBD6 | chr1 | 180366651 | - | IVNS1ABP | chr1 | 185274775 | - |
| 5UTR-5UTR | ENST00000475338 | ENST00000392007 | ACBD6 | chr1 | 180366651 | - | IVNS1ABP | chr1 | 185274775 | - |
| 5UTR-5UTR | ENST00000475338 | ENST00000459929 | ACBD6 | chr1 | 180366651 | - | IVNS1ABP | chr1 | 185274775 | - |
| 5UTR-intron | ENST00000475338 | ENST00000367497 | ACBD6 | chr1 | 180366651 | - | IVNS1ABP | chr1 | 185274775 | - |
| In-frame | ENST00000367595 | ENST00000367498 | ACBD6 | chr1 | 180366651 | - | IVNS1ABP | chr1 | 185274775 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000367595 | ACBD6 | chr1 | 180366651 | - | ENST00000367498 | IVNS1ABP | chr1 | 185274775 | - | 4270 | 1351 | 562 | 2622 | 686 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000367595 | ENST00000367498 | ACBD6 | chr1 | 180366651 | - | IVNS1ABP | chr1 | 185274775 | - | 0.000983897 | 0.99901605 |
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Fusion Genomic Features for ACBD6-IVNS1ABP |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for ACBD6-IVNS1ABP |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:180366651/chr1:185274775) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ACBD6 | . |
| FUNCTION: Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids. {ECO:0000269|PubMed:18268358}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ACBD6 | chr1:180366651 | chr1:185274775 | ENST00000367595 | - | 6 | 8 | 42_127 | 221 | 283.0 | Domain | ACB |
| Hgene | ACBD6 | chr1:180366651 | chr1:185274775 | ENST00000367595 | - | 6 | 8 | 69_73 | 221 | 283.0 | Region | Acyl-CoA binding |
| Hgene | ACBD6 | chr1:180366651 | chr1:185274775 | ENST00000367595 | - | 6 | 8 | 191_220 | 221 | 283.0 | Repeat | Note=ANK 1 |
| Tgene | IVNS1ABP | chr1:180366651 | chr1:185274775 | ENST00000367498 | 6 | 15 | 369_415 | 219 | 643.0 | Repeat | Note=Kelch 1 | |
| Tgene | IVNS1ABP | chr1:180366651 | chr1:185274775 | ENST00000367498 | 6 | 15 | 416_463 | 219 | 643.0 | Repeat | Note=Kelch 2 | |
| Tgene | IVNS1ABP | chr1:180366651 | chr1:185274775 | ENST00000367498 | 6 | 15 | 465_512 | 219 | 643.0 | Repeat | Note=Kelch 3 | |
| Tgene | IVNS1ABP | chr1:180366651 | chr1:185274775 | ENST00000367498 | 6 | 15 | 513_559 | 219 | 643.0 | Repeat | Note=Kelch 4 | |
| Tgene | IVNS1ABP | chr1:180366651 | chr1:185274775 | ENST00000367498 | 6 | 15 | 560_606 | 219 | 643.0 | Repeat | Note=Kelch 5 | |
| Tgene | IVNS1ABP | chr1:180366651 | chr1:185274775 | ENST00000367498 | 6 | 15 | 608_642 | 219 | 643.0 | Repeat | Note=Kelch 6 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ACBD6 | chr1:180366651 | chr1:185274775 | ENST00000367595 | - | 6 | 8 | 224_253 | 221 | 283.0 | Repeat | Note=ANK 2 |
| Tgene | IVNS1ABP | chr1:180366651 | chr1:185274775 | ENST00000367498 | 6 | 15 | 134_233 | 219 | 643.0 | Domain | Note=BACK | |
| Tgene | IVNS1ABP | chr1:180366651 | chr1:185274775 | ENST00000367498 | 6 | 15 | 32_99 | 219 | 643.0 | Domain | BTB |
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Fusion Gene Sequence for ACBD6-IVNS1ABP |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >1266_1266_1_ACBD6-IVNS1ABP_ACBD6_chr1_180366651_ENST00000367595_IVNS1ABP_chr1_185274775_ENST00000367498_length(transcript)=4270nt_BP=1351nt GGGCTGTTTGGAGGCGCTTGGGGCGCACAATCTGGGGCAGGCGGAACCTTAGTCCTCAGCCTCGCGTTTCCCGCGACTCCGCTCTCACCG CTACACTACCACACAAACGGCCTCCTTCCCCCACCCCCGGGGGCCCATCCCGGTGGCGGGCTCCGGAGCTCGGGACTGCTAATTTCAGCG AAACGATTAAAAGACGCCCCTACAGCTGACGGCACTTTCTCTCCTCCGGCAGGGAAGGACGTCCAGCGTAGCGTCGCCCGCGCTTCCCCG CCGGCGCAGAGCAGGCCTCACAGAATCGCACGCCGCTGGCACGCACGCCGCCCCGCCCCCACGGCCCAGCGCCAGCCGCGCCCCGCGCTC GCACGCATCCCGGCCTCACTGCCCCTCGACTCCTGTTCCGTTGGAGGGGCCTGAGGCGAGCCTGAGCGCGCTGTTGGCCGGAGGGAAGCC GGAGGAGACCGGGTCGACTGGGCAGAGCGGCAGAGGGTCGAGGAGCCTGCTCTGCACGCCCAGGGAGTAGAAGTGGGCAGGGAGCAGGGT CACGTGAGGGAGCGCGCCGCGACTGAGCTTGGGTCCGACTGGAGCTCAGGCTCGCGACCCAGACTGGTGGGCCAGGCCTCCAAGCCGGCC TTACACCCAATCCAAGGAGGACAGACCGGACACAGAGGGACGGAGCGAGCAAGGAGACATGGCTTCATCATTCCTGCCCGCGGGGGCCAT CACCGGCGACAGCGGTGGAGAGCTGAGCTCAGGGGACGACTCCGGGGAGGTGGAGTTCCCCCATAGCCCTGAGATCGAGGAGACCAGTTG CCTGGCCGAGCTGTTTGAGAAGGCTGCCGCGCACCTGCAAGGCCTGATTCAGGTGGCCAGCAGGGAGCAGCTCTTGTACCTGTATGCCAG GTACAAACAGGTCAAAGTTGGAAATTGTAATACTCCTAAACCAAGCTTCTTTGATTTTGAAGGAAAGCAAAAATGGGAAGCTTGGAAAGC ACTTGGTGATTCAAGCCCCAGCCAAGCAATGCAGGAATATATCGCAGTAGTTAAAAAACTAGATCCAGGTTGGAATCCTCAGATACCAGA GAAGAAAGGAAAAGAAGCAAATACAGGTTTTGGTGGGCCAGTTATTAGTTCTCTATATCATGAAGAAACCATCAGGGAAGAAGACAAAAA TATATTTGATTACTGCAGGGAAAACAACATTGACCATATAACCAAAGCCATCAAATCGAAAAATGTGGATGTGAATGTGAAAGATGAAGA GGGTAGGGCTCTACTTCACTGGGCCTGTGATCGAGGACATAAGGAACTAGTCACAGTGTTGCTGCAACATAGAGCTGACATTAACTGTCA GGTTCAAACCTTGTACTACTCAGCTGATCACAAGCTGCTTGATGGGAACCTACTAGATGGACAGGCTGAGGTGTTTGGCAGTGATGATGA CCACATTCAGTTTGTGCAGAAAAAGCCACCACGTGAGAATGGCCATAAGCAGATAAGTAGCAGTTCAACTGGATGTCTCTCTTCTCCAAA TGCTACAGTACAAAGCCCTAAGCATGAGTGGAAAATCGTTGCTTCAGAAAAGACTTCAAATAACACTTACTTGTGCCTGGCTGTGCTGGA TGGTATATTCTGTGTCATTTTTCTTCATGGGAGAAACAGCCCACAGAGCTCACCAACAAGTACTCCAAAACTAAGTAAGAGTTTAAGCTT TGAGATGCAACAAGATGAGCTAATCGAAAAGCCCATGTCTCCTATGCAGTACGCACGATCTGGTCTGGGAACAGCAGAGATGAATGGCAA ACTCATAGCTGCAGGTGGCTATAACAGAGAGGAATGTCTTCGAACAGTCGAATGCTATAATCCACATACAGATCACTGGTCCTTTCTTGC TCCCATGAGAACACCAAGAGCCCGATTTCAAATGGCTGTACTCATGGGCCAGCTCTATGTGGTAGGTGGATCAAATGGCCACTCAGATGA CCTGAGTTGTGGAGAGATGTATGATTCAAACATAGATGACTGGATTCCTGTTCCAGAATTGAGAACTAACCGTTGTAATGCAGGAGTGTG TGCTCTGAATGGAAAGTTATACATCGTTGGTGGCTCTGATCCATATGGTCAAAAAGGACTGAAAAATTGTGATGTATTTGATCCTGTAAC AAAGTTGTGGACAAGCTGTGCCCCTCTTAACATTCGGAGACACCAGTCTGCAGTCTGTGAGCTTGGTGGTTATTTGTACATAATCGGAGG TGCAGAATCTTGGAATTGTCTGAACACAGTAGAACGATACAATCCTGAAAATAATACCTGGACTTTAATTGCACCCATGAATGTGGCTAG GCGAGGAGCTGGAGTGGCTGTTCTTAATGGAAAACTGTTTGTATGTGGTGGCTTTGATGGTTCTCATGCCATCAGTTGTGTGGAAATGTA TGATCCAACTAGAAATGAATGGAAGATGATGGGAAATATGACTTCACCAAGGAGCAATGCTGGGATTGCAACTGTAGGGAACACCATTTA TGCAGTGGGAGGATTCGATGGCAATGAATTTCTGAATACGGTGGAAGTCTATAACCTTGAGTCAAATGAATGGAGCCCCTATACAAAGAT TTTCCAGTTTTAACAAATTTAAGACCCTCTCAAACTAACAGGCTTAGTGATGTAATTATGGTTAGTAGAGGTACACTTGTGAATAAAGAG GGTGGGTGGGTATAGATGTTGCTAACAGCAACACAAAGCTTTTGCATATTGCATACTATTAAACATGCTGTACATACTTTTTGGGTTTAT TTGGAAAGGAATGCAAAGATGAAGGTCTGTTTTGTGTACTTTTAAGACTTTGGTTATTTTACTTTTTGGAAAAGAATAAACCAAGAATTG ATTGGGCACATCATTTCAAGAAGTCCCCTCTCCTCCACATTTGTTTTGCCAATTTGCACATTAAATGACTCTTCCCTCAAATGTGTACTA TGGGGTAAAAGGGGTAGGGTTTAAAGATGTAGACAGTTGGGTTTTTTAAGGGCCCTTTTTCAATAACTGGAACACTCTATAACAAAGGAT ACTTATTTAAATAGATGACATTGACTATTTTTGTTTTTATTAAAAGGAAGCTTACATGCCTACCAATATTTAATCTTTTATGATTGCCTT TTTATAACTTTTTATATTCTCAGCAGAGTGCTTTACCAATTGAAGTAAAATGTGGCAGGCTGGAGTTATTGAAGCAGAGTGGCAGTCTTC AGTTTGCAGAGTAGGGGTCTGTCTTTTAAACTCTGAGTGCAAACTTCAGAGTTCTTGCCTTGGCTGCAGTTTTTTTCCTTCAAGAATGCA GTACTAACATTTATTTGAGTGGAGTTACTGAACAGTAACATAGCTGTGATTTTTGGTATTTGAAACACTGGTTTTAAATATTTTGACTTG TTGAGGGTATGTTTTATATAGCAAGACATTATATAGCAGTAAAAAATGGTGTTTTATCTTCTATATAATTCCTGTTTTTATTATTAACAA AACAGTCCTAAATAGCAGCCCTCAATTGTGAAAAAATTTACTTTAAACTACATTAGGTTGTGAATGCAGGTTTTATCAGAACTATGTTTT TGTTCAGTTTATCTGTTCATATGGATAAATATTGGTTGGGATGACTTGGTGTCTAATGTGTAGTGCTACACACCTAACTTATGGGGCCAA AATAGCATGTCCTAATGCTTGCTGCTGATTTAAACACATTAAAGGTACTTTGCAGGAAATCCTTGCACCATGGGATTAATATCCAATTGC TGCTTGTACACTCATTCATTACTAAAAGTTTTGAGAAATTTTTTTTTCCAGTAATGAGCTTAAGAAATTTGTGGAAAATAACTCACCTGG CATCTTACATCTGAAATAAGGAATGATATAAGGTTTTTTTTTCTCACAGAAGATGAAGCACACAGGAACCTAATGGGCCAACTGGGATGA GGTGACTATTCTGAGATGACTATTCAGTGGCTAACTTGGGTTAGGAAGAAAATAATTAGGTATTTTCTCCAAATGTTCACTGGTACTCTG CCACTTTATTTCTCTCATCTGTTACACAAAGAACCACCAGGAAAGCAAATCAGTTTGGTTGGTAACTCTGTAATTCCTAACTATCACTGG TTTGGTTCTGGACTAAAACTACATTGACAGATTGAATTTGCCTAATATGATGACTGTTTTTAATATGGATCTGTATGTGTTCTATTCAGC >1266_1266_1_ACBD6-IVNS1ABP_ACBD6_chr1_180366651_ENST00000367595_IVNS1ABP_chr1_185274775_ENST00000367498_length(amino acids)=686AA_BP=262 MSLGPTGAQARDPDWWARPPSRPYTQSKEDRPDTEGRSEQGDMASSFLPAGAITGDSGGELSSGDDSGEVEFPHSPEIEETSCLAELFEK AAAHLQGLIQVASREQLLYLYARYKQVKVGNCNTPKPSFFDFEGKQKWEAWKALGDSSPSQAMQEYIAVVKKLDPGWNPQIPEKKGKEAN TGFGGPVISSLYHEETIREEDKNIFDYCRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQVQTLYYS ADHKLLDGNLLDGQAEVFGSDDDHIQFVQKKPPRENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNNTYLCLAVLDGIFCVIF LHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRA RFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCA PLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEW -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ACBD6-IVNS1ABP |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ACBD6-IVNS1ABP |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ACBD6-IVNS1ABP |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ACBD6 | C0020796 | Profound Mental Retardation | 1 | CTD_human |
| Hgene | ACBD6 | C0025363 | Mental Retardation, Psychosocial | 1 | CTD_human |
| Hgene | ACBD6 | C0917816 | Mental deficiency | 1 | CTD_human |
| Hgene | ACBD6 | C3714756 | Intellectual Disability | 1 | CTD_human;GENOMICS_ENGLAND |
| Tgene | C0033578 | Prostatic Neoplasms | 1 | CTD_human | |
| Tgene | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
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