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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARFGAP2-FBRSL1 (FusionGDB2 ID:HG84364TG57666)

Fusion Gene Summary for ARFGAP2-FBRSL1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARFGAP2-FBRSL1
Fusion gene ID: hg84364tg57666
HgeneTgene
Gene symbol

ARFGAP2

FBRSL1

Gene ID

84364

57666

Gene nameADP ribosylation factor GTPase activating protein 2fibrosin like 1
SynonymsIRZ|NBLA10535|ZFP289|ZNF289-
Cytomap('ARFGAP2')('FBRSL1')

11p11.2

12q24.33

Type of geneprotein-codingprotein-coding
DescriptionADP-ribosylation factor GTPase-activating protein 2GTPase-activating protein ZNF289zinc finger protein 289, ID1 regulatedfibrosin-1-like proteinAUTS2-like proteinHBV X-transactivated gene 9 proteinHBV XAg-transactivated protein 9
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000319543, ENST00000419701, 
ENST00000426335, ENST00000524782, 
ENST00000395449, 
Fusion gene scores* DoF score6 X 6 X 4=1449 X 9 X 8=648
# samples 69
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/648*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARFGAP2 [Title/Abstract] AND FBRSL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARFGAP2(47187819)-FBRSL1(133144067), # samples:3
Anticipated loss of major functional domain due to fusion event.ARFGAP2-FBRSL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARFGAP2-FBRSL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARFGAP2-FBRSL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARFGAP2-FBRSL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARFGAP2-FBRSL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ARFGAP2-FBRSL1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ARFGAP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across FBRSL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-YL-A8HL-01AARFGAP2chr11

47187819

-FBRSL1chr12

133144067

+
ChimerDB4PRADTCGA-YL-A8HLARFGAP2chr11

47187819

-FBRSL1chr12

133144067

+


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Fusion Gene ORF analysis for ARFGAP2-FBRSL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000319543ENST00000542061ARFGAP2chr11

47187819

-FBRSL1chr12

133144067

+
5CDS-intronENST00000419701ENST00000542061ARFGAP2chr11

47187819

-FBRSL1chr12

133144067

+
5CDS-intronENST00000426335ENST00000542061ARFGAP2chr11

47187819

-FBRSL1chr12

133144067

+
5CDS-intronENST00000524782ENST00000542061ARFGAP2chr11

47187819

-FBRSL1chr12

133144067

+
5UTR-3CDSENST00000395449ENST00000261673ARFGAP2chr11

47187819

-FBRSL1chr12

133144067

+
5UTR-3CDSENST00000395449ENST00000434748ARFGAP2chr11

47187819

-FBRSL1chr12

133144067

+
5UTR-intronENST00000395449ENST00000542061ARFGAP2chr11

47187819

-FBRSL1chr12

133144067

+
Frame-shiftENST00000319543ENST00000261673ARFGAP2chr11

47187819

-FBRSL1chr12

133144067

+
Frame-shiftENST00000319543ENST00000434748ARFGAP2chr11

47187819

-FBRSL1chr12

133144067

+
Frame-shiftENST00000419701ENST00000261673ARFGAP2chr11

47187819

-FBRSL1chr12

133144067

+
Frame-shiftENST00000419701ENST00000434748ARFGAP2chr11

47187819

-FBRSL1chr12

133144067

+
In-frameENST00000426335ENST00000261673ARFGAP2chr11

47187819

-FBRSL1chr12

133144067

+
In-frameENST00000426335ENST00000434748ARFGAP2chr11

47187819

-FBRSL1chr12

133144067

+
In-frameENST00000524782ENST00000261673ARFGAP2chr11

47187819

-FBRSL1chr12

133144067

+
In-frameENST00000524782ENST00000434748ARFGAP2chr11

47187819

-FBRSL1chr12

133144067

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000426335ARFGAP2chr1147187819-ENST00000434748FBRSL1chr12133144067+506611632636551209
ENST00000426335ARFGAP2chr1147187819-ENST00000261673FBRSL1chr12133144067+365611632636551210
ENST00000524782ARFGAP2chr1147187819-ENST00000434748FBRSL1chr12133144067+5677177422942661345
ENST00000524782ARFGAP2chr1147187819-ENST00000261673FBRSL1chr12133144067+4267177422942661346

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000426335ENST00000434748ARFGAP2chr1147187819-FBRSL1chr12133144067+0.0052298510.9947701
ENST00000426335ENST00000261673ARFGAP2chr1147187819-FBRSL1chr12133144067+0.0145758920.9854241
ENST00000524782ENST00000434748ARFGAP2chr1147187819-FBRSL1chr12133144067+0.0068217250.99317825
ENST00000524782ENST00000261673ARFGAP2chr1147187819-FBRSL1chr12133144067+0.0168407450.9831593

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Fusion Genomic Features for ARFGAP2-FBRSL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARFGAP2chr1147187818-FBRSL1chr12133144066+0.0062868090.9937132
ARFGAP2chr1147187818-FBRSL1chr12133144066+0.0062868090.9937132
ARFGAP2chr1147187818-FBRSL1chr12133144066+0.0062868090.9937132
ARFGAP2chr1147187818-FBRSL1chr12133144066+0.0062868090.9937132

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARFGAP2-FBRSL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:47187819/chr12:133144067)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARFGAP2chr11:47187819chr12:133144067ENST00000524782-1516242_308515522.0Coiled coilOntology_term=ECO:0000255
HgeneARFGAP2chr11:47187819chr12:133144067ENST00000524782-151611_127515522.0DomainArf-GAP
HgeneARFGAP2chr11:47187819chr12:133144067ENST00000524782-151626_49515522.0Zinc fingerC4-type
TgeneFBRSL1chr11:47187819chr12:133144067ENST00000434748417263_5172151046.0Compositional biasNote=Pro-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ARFGAP2-FBRSL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5837_5837_1_ARFGAP2-FBRSL1_ARFGAP2_chr11_47187819_ENST00000426335_FBRSL1_chr12_133144067_ENST00000261673_length(transcript)=3656nt_BP=1163nt
GCGGTTGTGTCTGGGAAGGAGAGAAAATGGCGGCGGAGCCGAACAAGACCGAAATCCAGACTCTTTTTAAGAGGCTTCGCGCAGTTCCAA
CCAACAAGGCCTGTTTCGACTGCGGCGCCAAGAATCCGAGTTGGGCCAGCATCACGTACGGTGTTTTCTTGTGCATTGACTGTTCCGGGG
TGCACCGCTCCCTGGGCGTCCATCTGAGCTTCATCAGGTCCACAGAGTTGGATTCCAACTGGAACTGGTTCCAGCTGAGGTGTATGCAGG
TCGGCGGGAATGCCAATGCGCTGGGTGCCAAGAAAGGCCTAGGGGCCCAGAAGGTGAGCAGCCAGAGCTTCAGTGAGATTGAGCGGCAGG
CTCAGGTGGCAGAGAAGCTCCGTGAGCAGCAGGCAGCCGATGCCAAGAAGCAGGCGGAGGAGTCCATGGTCGCCTCCATGCGTCTGGCCT
ACCAGGAGCTCCAGATTGATCGTAAGAAAGAGGAAAAGAAGCTACAGAATCTGGAAGGGAAGAAGCGAGAGCAGGCAGAAAGGTTGGGCA
TGGGCTTGGTATCCCGAAGCTCTGTCTCCCACTCCGTGCTGTCTGAGATGCAGGTGATTGAGCAGGAAACCCCAGTGAGTGCAAAATCCT
CTCGCTCGCAGCTGGACTTGTTTGACGATGTTGGTACTTTCGCCTCTGGACCCCCAAAGTACAAGGACAATCCCTTTTCCTTAGGGGAAA
GCTTTGGCTCCCGCTGGGATACAGATGCTGCCTGGGGTATGGACAGGGTAGAGGAGAAGGAGCCAGAAGTGACCATCTCAAGCATCCGGC
CTATTTCAGAAAGAGCCACAAACCGGAGGGAAGTGGAGAGCCGGAGCTCAGGCCTCGAGTCTAGTGAGGCGCGTCAGAAATTCGCAGGAG
CCAAAGCCATCTCATCTGACATGTTCTTTGGGCGGGAGGTGGATGCAGAGTATGAGGCCAGGTCTCGGCTGCAGCAGCTCTCAGGCAGCA
GTGCCATCAGCTCTTCAGACCTCTTTGGGGACATGGATGGAGCTCACGGAGCAGGAAGTGTATCTCTGGGGAACGTGCTGCCTACAGCGG
ACATTGCCCAGTTTAAGCAGGGTGTCAAGTCTGTGGCTGGGAAAATGGCTGTGCTGGCCAATGGTGTGATGAATTCCTTGCAGGCATCCG
TGGGCTCTGAGAAGCTCTTTGCGCCGGGAACCGATAAAGGCCCAGCGCTTGAGAAGTCGGAGGCCAAGGCCGGGCCGGTGCCCAAGGTGT
CAGGCCTGGAGCGCAGCCGCGAGCTCAGCGCCGAGAGCTTCCTGCCCACTGCCAGCCCCGCGCCCCATGCCGCGCCCTGCCCGGGGCCCC
CGCCCGGCTCCCGCGCCAATCCCTTGGTGAAGAAGGAACCCCCCGCCCCGCACCGCCACACCCCGCAGCCGCCACCCCCGCAGCCCCGCG
GCCTGCTCCCGACACACGTGCCTGCATCCCTGGGCGCCTTCGCGGGCCACAGCCAGGCGGCAGCCAACGGCCTGCACGGCCTCAGCAGGA
GCAGCAGCGCCCCCCTGGGCCTGGGGAAGCACGTGTCGCTGTCGCCACACGGGCCGGGCCCCCACCTGTCTACCTCACACCTGGCGCTCC
GGTCCCAGGCGCAGCACCAGCTCCACGCGGCCATGTTTGCCGCACCCCCGACACTGCCCCCGCCCCCGGCGCTGCCGGCCAGCAGCCTGG
TCCTCCCAGGACACCCGGCCGATCACGAGCTGCTCAGGCAAGAGCTGAACACGCGGTTTCTGGTGCAGAGCGCCGAGCGGCCTGGCGCCT
CCCTGGGCCCGGGGGCTCTGCTGCGGGCGGAGTTCCATCAGCACCAGCACACACACCAGCACACGCACCAACACACACACCAGCACCAAC
ACACATTCGCCCCCTTCCCCGCAGGGCTGCCCCCGACGCCGCCCGCCGCACCCCCGCCGTTTGACAAGTATGCGCCCAAGCTGGACAGCC
CCTACTTCCGACATTCCAGCGTGAGTTTCTTCCCGTCCTTCCCTCCTGCCATCCCGGGACTGCCCACCCTGCTCCCACACCCCGGCCCCT
TCGGGTCCCTGCAGGGCGCTTTTCAGCCTAAGGTGTCTGACCCGTACCGGGCGGTGGTCAAGGTGAGCACGTGTTGGGAAGGCCCGTGGC
AAGGGAGGACTCTGGTGCCCCCGGGGCGGCCTCGGGGGGCCCGTGACAGCAGGAGTCTGCAGAAAACATGGGTGGGGGTGGCACCAGCCC
CACTGAGCGCTTCCATCCTGTCGCAGAAGCCGGGGAGGTGGTGTGCCGTGCACGTGCAGATCGCCTGGCAGATCTACCGTCACCAGCAGA
AGATAAAGGAGATGCAGCTGGACCCCCACAAGCTGGAGGTGGGTGCAAAGCTGGACCTGTTCGGCAGACCCCCTGCCCCGGGCGTGTTTG
CAGGCTTCCACTACCCACAGGACCTGGCCCGGCCCCTCTTCCCCAGCACAGGTGCCGCCCATCCTGCCTCCAACCCATTTGGACCCTCAG
CCCATCCTGGCAGCTTCCTGCCCACTGGCCCCCTGACAGACCCTTTCAGCAGACCGAGCACCTTTGGGGGCCTGGGCAGCCTGAGCAGCC
ACGCCTTTGGGGGCCTGGGCAGCCATGCACTGGCTCCCGGTGGCAGCATCTTTGCCCCCAAGGAGGGCTCCTCCGTGCACGGCCTGCCCA
GCCCCCATGAGGCCTGGAACCGACTGCACCGGGCACCGCCCTCCTTCCCGGCTCCGCCCCCGTGGCCCAAGTCCGTGGACGCGGAGCGGG
TGTCAGCCCTGACCAACCATGACCGAGAGCCGGACAATGGCAAGGAGGAGCAGGAACGGGACCTCCTGGAGAAGACGCGCCTGCTGAGCC
GGGCCTCGCCCGCCACCCCCGCTGGCCACCCCGTCAGCGGCCTCCTGCTCCGGGCCCAGAGCGAGCTGGGCCGGTCCGGGGCCCCCGCGG
AGCGCGAGGCCGAACCTCGGGTCAAGGAGAGCCGCTCCCCGGCCAAGGAGGAGGCCGCCAAGATGCCCGCGCGCGCATCCCCGCCCCACA
GCAAGGCGGCCCCTGGAGACGTGAAGGTCAAGGAGGAGCGCGGGGAGGACGAGGCCTCCGAGCCCCCGGCGGGCGGCCTGCACCCCGCGC
CCCTGCAGCTCGGCCTGGGCCGCGAGCGCCTGGGCGCGCCGGGCTTCGCGTGGGAGCCTTTCCGCGGCCTGGAGCTGCCACGTCGCGCCT
TCCCCGCTGCCGCCCCCGCCCCGGGCTCCGCCGCCCTCTTGGAGCCCCCGGAGCGCCCCTACCGCGACCGCGAGCCCCACGGCTACAGCC
CCGAGCGCCTGCGCGGGGAGCTGGAGCGCGCGCGGGCCCCGCACCTGCCGCCCGCCGCCCCCGCCTTGGACGGCGCGCTGCTGCCCTCGC
TGGGAGCCCTGCACTTCCCGCGCCTCTCGCCCGCCGCGCTGCACAATGGGCTCCTGGCGCGGACCCCGCCCGCCGCCGCCGCCCTCGGCG
CACCGCCCCCCCTGGTGACGGCGGCCGGGCCCCCCACGCCCCCCGGGCCGCCGCGGAGCCGGACTACTCCGCTGGGGGGCCTCGGGCCGG

>5837_5837_1_ARFGAP2-FBRSL1_ARFGAP2_chr11_47187819_ENST00000426335_FBRSL1_chr12_133144067_ENST00000261673_length(amino acids)=1210AA_BP=376
MAAEPNKTEIQTLFKRLRAVPTNKACFDCGAKNPSWASITYGVFLCIDCSGVHRSLGVHLSFIRSTELDSNWNWFQLRCMQVGGNANALG
AKKGLGAQKVSSQSFSEIERQAQVAEKLREQQAADAKKQAEESMVASMRLAYQELQIDRKKEEKKLQNLEGKKREQAERLGMGLVSRSSV
SHSVLSEMQVIEQETPVSAKSSRSQLDLFDDVGTFASGPPKYKDNPFSLGESFGSRWDTDAAWGMDRVEEKEPEVTISSIRPISERATNR
REVESRSSGLESSEARQKFAGAKAISSDMFFGREVDAEYEARSRLQQLSGSSAISSSDLFGDMDGAHGAGSVSLGNVLPTADIAQFKQGV
KSVAGKMAVLANGVMNSLQASVGSEKLFAPGTDKGPALEKSEAKAGPVPKVSGLERSRELSAESFLPTASPAPHAAPCPGPPPGSRANPL
VKKEPPAPHRHTPQPPPPQPRGLLPTHVPASLGAFAGHSQAAANGLHGLSRSSSAPLGLGKHVSLSPHGPGPHLSTSHLALRSQAQHQLH
AAMFAAPPTLPPPPALPASSLVLPGHPADHELLRQELNTRFLVQSAERPGASLGPGALLRAEFHQHQHTHQHTHQHTHQHQHTFAPFPAG
LPPTPPAAPPPFDKYAPKLDSPYFRHSSVSFFPSFPPAIPGLPTLLPHPGPFGSLQGAFQPKVSDPYRAVVKVSTCWEGPWQGRTLVPPG
RPRGARDSRSLQKTWVGVAPAPLSASILSQKPGRWCAVHVQIAWQIYRHQQKIKEMQLDPHKLEVGAKLDLFGRPPAPGVFAGFHYPQDL
ARPLFPSTGAAHPASNPFGPSAHPGSFLPTGPLTDPFSRPSTFGGLGSLSSHAFGGLGSHALAPGGSIFAPKEGSSVHGLPSPHEAWNRL
HRAPPSFPAPPPWPKSVDAERVSALTNHDREPDNGKEEQERDLLEKTRLLSRASPATPAGHPVSGLLLRAQSELGRSGAPAEREAEPRVK
ESRSPAKEEAAKMPARASPPHSKAAPGDVKVKEERGEDEASEPPAGGLHPAPLQLGLGRERLGAPGFAWEPFRGLELPRRAFPAAAPAPG
SAALLEPPERPYRDREPHGYSPERLRGELERARAPHLPPAAPALDGALLPSLGALHFPRLSPAALHNGLLARTPPAAAALGAPPPLVTAA

--------------------------------------------------------------
>5837_5837_2_ARFGAP2-FBRSL1_ARFGAP2_chr11_47187819_ENST00000426335_FBRSL1_chr12_133144067_ENST00000434748_length(transcript)=5066nt_BP=1163nt
GCGGTTGTGTCTGGGAAGGAGAGAAAATGGCGGCGGAGCCGAACAAGACCGAAATCCAGACTCTTTTTAAGAGGCTTCGCGCAGTTCCAA
CCAACAAGGCCTGTTTCGACTGCGGCGCCAAGAATCCGAGTTGGGCCAGCATCACGTACGGTGTTTTCTTGTGCATTGACTGTTCCGGGG
TGCACCGCTCCCTGGGCGTCCATCTGAGCTTCATCAGGTCCACAGAGTTGGATTCCAACTGGAACTGGTTCCAGCTGAGGTGTATGCAGG
TCGGCGGGAATGCCAATGCGCTGGGTGCCAAGAAAGGCCTAGGGGCCCAGAAGGTGAGCAGCCAGAGCTTCAGTGAGATTGAGCGGCAGG
CTCAGGTGGCAGAGAAGCTCCGTGAGCAGCAGGCAGCCGATGCCAAGAAGCAGGCGGAGGAGTCCATGGTCGCCTCCATGCGTCTGGCCT
ACCAGGAGCTCCAGATTGATCGTAAGAAAGAGGAAAAGAAGCTACAGAATCTGGAAGGGAAGAAGCGAGAGCAGGCAGAAAGGTTGGGCA
TGGGCTTGGTATCCCGAAGCTCTGTCTCCCACTCCGTGCTGTCTGAGATGCAGGTGATTGAGCAGGAAACCCCAGTGAGTGCAAAATCCT
CTCGCTCGCAGCTGGACTTGTTTGACGATGTTGGTACTTTCGCCTCTGGACCCCCAAAGTACAAGGACAATCCCTTTTCCTTAGGGGAAA
GCTTTGGCTCCCGCTGGGATACAGATGCTGCCTGGGGTATGGACAGGGTAGAGGAGAAGGAGCCAGAAGTGACCATCTCAAGCATCCGGC
CTATTTCAGAAAGAGCCACAAACCGGAGGGAAGTGGAGAGCCGGAGCTCAGGCCTCGAGTCTAGTGAGGCGCGTCAGAAATTCGCAGGAG
CCAAAGCCATCTCATCTGACATGTTCTTTGGGCGGGAGGTGGATGCAGAGTATGAGGCCAGGTCTCGGCTGCAGCAGCTCTCAGGCAGCA
GTGCCATCAGCTCTTCAGACCTCTTTGGGGACATGGATGGAGCTCACGGAGCAGGAAGTGTATCTCTGGGGAACGTGCTGCCTACAGCGG
ACATTGCCCAGTTTAAGCAGGGTGTCAAGTCTGTGGCTGGGAAAATGGCTGTGCTGGCCAATGGTGTGATGAATTCCTTGCAGGCATCCG
TGGGCTCTGAGAAGCTCTTTGCGCCGGGAACCGATAAAGGCCCAGCGCTTGAGAAGTCGGAGGCCAAGGCCGGGCCGGTGCCCAAGGTGT
CAGGCCTGGAGCGCAGCCGCGAGCTCAGCGCCGAGAGCTTCCTGCCCACTGCCAGCCCCGCGCCCCATGCCGCGCCCTGCCCGGGGCCCC
CGCCCGGCTCCCGCGCCAATCCCTTGGTGAAGAAGGAACCCCCCGCCCCGCACCGCCACACCCCGCAGCCGCCACCCCCGCAGCCCCGCG
GCCTGCTCCCGACACACGTGCCTGCATCCCTGGGCGCCTTCGCGGGCCACAGCCAGGCGGCAGCCAACGGCCTGCACGGCCTCAGCAGGA
GCAGCAGCGCCCCCCTGGGCCTGGGGAAGCACGTGTCGCTGTCGCCACACGGGCCGGGCCCCCACCTGTCTACCTCACACCTGGCGCTCC
GGTCCCAGGCGCAGCACCAGCTCCACGCGGCCATGTTTGCCGCACCCCCGACACTGCCCCCGCCCCCGGCGCTGCCGGCCAGCAGCCTGG
TCCTCCCAGGACACCCGGCCGATCACGAGCTGCTCAGGCAAGAGCTGAACACGCGGTTTCTGGTGCAGAGCGCCGAGCGGCCTGGCGCCT
CCCTGGGCCCGGGGGCTCTGCTGCGGGCGGAGTTCCATCAGCACCAGCACACACACCAGCACACGCACCAACACACACACCAGCACCAAC
ACACATTCGCCCCCTTCCCCGCAGGGCTGCCCCCGACGCCGCCCGCCGCACCCCCGCCGTTTGACAAGTATGCGCCCAAGCTGGACAGCC
CCTACTTCCGACATTCCAGCGTGAGTTTCTTCCCGTCCTTCCCTCCTGCCATCCCGGGACTGCCCACCCTGCTCCCACACCCCGGCCCCT
TCGGGTCCCTGCAGGGCGCTTTTCAGCCTAAGGTGTCTGACCCGTACCGGGCGGTGGTCAAGGTGAGCACGTGTTGGGAAGGCCCGTGGC
AAGGGAGGACTCTGGTGCCCCCGGGGCGGCCTCGGGGGGCCCGTGACAGCAGGAGTCTGCAGAAAACATGGGTGGGGGTGGCACCAGCCC
CACTGAGCGCTTCCATCCTGTCGCAGAAGCCGGGGAGGTGGTGTGCCGTGCACGTGCAGATCGCCTGGCAGATCTACCGTCACCAGCAGA
AGATAAAGGAGATGCAGCTGGACCCCCACAAGCTGGAGGTGGGTGCAAAGCTGGACCTGTTCGGCAGACCCCCTGCCCCGGGCGTGTTTG
CAGGCTTCCACTACCCACAGGACCTGGCCCGGCCCCTCTTCCCCAGCACAGGTGCCGCCCATCCTGCCTCCAACCCATTTGGACCCTCAG
CCCATCCTGGCAGCTTCCTGCCCACTGGCCCCCTGACAGACCCTTTCAGCAGACCGAGCACCTTTGGGGGCCTGGGCAGCCTGAGCAGCC
ACGCCTTTGGGGGCCTGGGCAGCCATGCACTGGCTCCCGGTGGCAGCATCTTTGCCCCCAAGGAGGGCTCCTCCGTGCACGGCCTGCCCA
GCCCCCATGAGGCCTGGAACCGACTGCACCGGGCACCGCCCTCCTTCCCGGCTCCGCCCCCGTGGCCCAAGTCCGTGGACGCGGAGCGGG
TGTCAGCCCTGACCAACCATGACCGAGAGCCGGACAATGGCAAGGAGGAGCAGGAACGGGACCTCCTGGAGAAGACGCGCCTGCTGAGCC
GGGCCTCGCCCGCCACCCCCGCTGGCCACCCCGTCAGCGGCCTCCTGCTCCGGGCCCAGAGCGAGCTGGGCCGGTCCGGGGCCCCCGCGG
AGCGCGAGGCCGAACCTCGGGTCAAGGAGAGCCGCTCCCCGGCCAAGGAGGAGGCCGCCAAGATGCCCGCGCGCGCATCCCCGCCCCACA
GCAAGGCGGCCCCTGGAGACGTGAAGGTCAAGGAGGAGCGCGGGGAGGACGAGGCCTCCGAGCCCCCGGCGGGCGGCCTGCACCCCGCGC
CCCTGCAGCTCGGCCTGGGCCGCGAGCGCCTGGGCGCGCCGGGCTTCGCGTGGGAGCCTTTCCGCGGCCTGGAGCTGCCACGTCGCGCCT
TCCCCGCTGCCGCCCCCGCCCCGGGCTCCGCCGCCCTCTTGGAGCCCCCGGAGCGCCCCTACCGCGACCGCGAGCCCCACGGCTACAGCC
CCGAGCGCCTGCGCGGGGAGCTGGAGCGCGCGCGGGCCCCGCACCTGCCGCCCGCCGCCCCCGCCTTGGACGGCGCGCTGCTGCCCTCGC
TGGGAGCCCTGCACTTCCCGCGCCTCTCGCCCGCCGCGCTGCACAATGGGCTCCTGGCGCGGACCCCGCCCGCCGCCGCCGCCCTCGGCG
CACCGCCCCCCCTGGTGACGGCGGCCGGGCCCCCCACGCCCCCCGGGCCGCCGCGGAGCCGGACTACTCCGCTGGGGGGCCTCGGGCCGG
GCGAGGCGCGCGACTACTCCCCGTCCCGAAATCCCCCGGAGGTGGAGGCGCGGTAGCCCCGGGGCCGCAGACGCCTCTCCGAGCGGAGCG
CACCGCTGTCCGTCTCTCCATCAGTTCCTAGAACTCAAGCACAGCTCCCGCCGATCCTGGGGCGGCGCCGCCTCTCCACCCGCAGCCTGC
GGAGGCGGGGACTTGGGTGTCGGCTTTTCTGAGGGTGATCTTTTGTTTTCCGAGTTTGGGATTCGGCTGTTGGGAAAAAAAAATCGCGTT
TGTACCTTTTCCCCCCACAGATGAGAAGTGTTTGTAATGGATTTGTATTTTTCTTAATTTTATGCTCTTTAGACGTTTAAAAGAACCAAA
AAAGAAACTTTTGCTTCTTCGTTTTCGGTTGGGATTTGCAGTTTAATGGCCTCAGATCCTTCTCCAGATCCCCAGGGTTTCTTTGTCTTA
TTTATGGAGAAAAACCGGTCACTTTGTCCAGCGCACTGTGAGGCCCCCACTCAGGCCAGCCCTGGCCCCCCCTTGGTACTTGGAACCGAA
GTTACAGATTATATTAAAATAATAATGTACAAAACTTTGTTTTTTTGCCTTATTATGCAGAAGTGTAATTTCTTTTTTGGTTTGTTTTTT
TAAAAGCAAACGAAACGTGTAAATAGTCTGTTGATATAAATATATGACGTTACTAAATTCTTAATCTAGATAGACTTTATAAAAACCGTT
TCCAGAAACCCCTCTGGTTGTTTGTCTAACATGGTCACAAAAACCCAGGCGCTGCTGGCTGTAAACATTATCAGAAGTTTAATGGCAGCA
ACTTTCCTTCAACTATGCAAGCGCTTCCCGGCGGCTCTGCTGGTTGGGGGAGGAAGGTTCCGCCAGCGACCTCCCAGCCCCTGGGTCCGT
GGAGGGGTTGGGTCCCCCAGCAGAGCCCCTGGGCCAGCAGAACAGCACTCCTGGGCGGCTCCTGTGGGCTTCAGGACTGGCCGGCTCCAG
CCGCAAGGGCGATGCTGTGGACGTTTGTGTGGATGGTGCAGTGTTCTTGGAATCTGTAGACCAGATCGGTGGAGGTATAGAAGTGCAAGA
GTCTAAAGGCTGATTTTACACACACACACACACACACACACACACACACAAAATCACTGCTGTGTGTTTTCTTCCGCCTGAGGCATCAGC
GTCACCTCGGTGTGGTCGTCGCCTCCCAGGCCCTTGGCCTGGCCTCCTCTCAGTTTGGGTTTTGCCCTCACCCACATGAGCCCCCCCATG
CCCTGCCCCCCTTGCGGCCTTTTGTGTTCCCCGATGTCTGGGCTGTGTCCCTGCCGGGATTCCCAGCCTTCGGGGTCAGCCGTCGAGCCA
CTTGCTTTGCTCAGTTCTGTGTTTCAGCCACATTTCCACGGTGGACCCTGTTTGTTTTAAATATTCTGTTCCCATGTCAATCAGTGACGA

>5837_5837_2_ARFGAP2-FBRSL1_ARFGAP2_chr11_47187819_ENST00000426335_FBRSL1_chr12_133144067_ENST00000434748_length(amino acids)=1209AA_BP=376
MAAEPNKTEIQTLFKRLRAVPTNKACFDCGAKNPSWASITYGVFLCIDCSGVHRSLGVHLSFIRSTELDSNWNWFQLRCMQVGGNANALG
AKKGLGAQKVSSQSFSEIERQAQVAEKLREQQAADAKKQAEESMVASMRLAYQELQIDRKKEEKKLQNLEGKKREQAERLGMGLVSRSSV
SHSVLSEMQVIEQETPVSAKSSRSQLDLFDDVGTFASGPPKYKDNPFSLGESFGSRWDTDAAWGMDRVEEKEPEVTISSIRPISERATNR
REVESRSSGLESSEARQKFAGAKAISSDMFFGREVDAEYEARSRLQQLSGSSAISSSDLFGDMDGAHGAGSVSLGNVLPTADIAQFKQGV
KSVAGKMAVLANGVMNSLQASVGSEKLFAPGTDKGPALEKSEAKAGPVPKVSGLERSRELSAESFLPTASPAPHAAPCPGPPPGSRANPL
VKKEPPAPHRHTPQPPPPQPRGLLPTHVPASLGAFAGHSQAAANGLHGLSRSSSAPLGLGKHVSLSPHGPGPHLSTSHLALRSQAQHQLH
AAMFAAPPTLPPPPALPASSLVLPGHPADHELLRQELNTRFLVQSAERPGASLGPGALLRAEFHQHQHTHQHTHQHTHQHQHTFAPFPAG
LPPTPPAAPPPFDKYAPKLDSPYFRHSSVSFFPSFPPAIPGLPTLLPHPGPFGSLQGAFQPKVSDPYRAVVKVSTCWEGPWQGRTLVPPG
RPRGARDSRSLQKTWVGVAPAPLSASILSQKPGRWCAVHVQIAWQIYRHQQKIKEMQLDPHKLEVGAKLDLFGRPPAPGVFAGFHYPQDL
ARPLFPSTGAAHPASNPFGPSAHPGSFLPTGPLTDPFSRPSTFGGLGSLSSHAFGGLGSHALAPGGSIFAPKEGSSVHGLPSPHEAWNRL
HRAPPSFPAPPPWPKSVDAERVSALTNHDREPDNGKEEQERDLLEKTRLLSRASPATPAGHPVSGLLLRAQSELGRSGAPAEREAEPRVK
ESRSPAKEEAAKMPARASPPHSKAAPGDVKVKEERGEDEASEPPAGGLHPAPLQLGLGRERLGAPGFAWEPFRGLELPRRAFPAAAPAPG
SAALLEPPERPYRDREPHGYSPERLRGELERARAPHLPPAAPALDGALLPSLGALHFPRLSPAALHNGLLARTPPAAAALGAPPPLVTAA

--------------------------------------------------------------
>5837_5837_3_ARFGAP2-FBRSL1_ARFGAP2_chr11_47187819_ENST00000524782_FBRSL1_chr12_133144067_ENST00000261673_length(transcript)=4267nt_BP=1774nt
CCCGCCCCGGCTGCGGATTGGCCCGGCGCGGCGTTGATTCTTGCGGCCGCGGTTGTCGTCGCCGCCCCCGTCCCGCCGGCTGCCCATTGG
TCCAGATCGGACTCCAATCACCCCACCCCTCGGCTGGCCCAGGCACCGCTGAGGCCGGCCTGGTGAGCCCGCCCTCCCCGCCGTGGATTG
GCCCGCGGCGGGACCCGTCAGCCGCGGTTGTGTCTGGGAAGGAGAGAAAATGGCGGCGGAGCCGAACAAGACCGAAATCCAGACTCTTTT
TAAGAGGCTTCGCGCAGTTCCAACCAACAAGGCCTGTTTCGACTGCGGCGCCAAGAATCCGAGTTGGGCCAGCATCACGTACGGTGTTTT
CTTGTGCATTGACTGTTCCGGGGTGCACCGCTCCCTGGGCGTCCATCTGAGCTTCATCAGGTCCACAGAGTTGGATTCCAACTGGAACTG
GTTCCAGCTGAGGTGTATGCAGGTCGGCGGGAATGCCAATGCGACGGCTTTTTTTCGCCAACATGGATGCACAGCCAATGATGCCAACAC
CAAATATAATAGCCGAGCTGCCCAGATGTACCGGGAGAAGATCCGGCAGCTGGGGAGTGCGGCCCTGGCTAGGCATGGCACTGATCTTTG
GATAGACAACATGAGTAGTGCCGTTCCTAATCACTCCCCAGAGAAGAAGGACTCTGATTTCTTCACAGAACACACTCAACCCCCTGCCTG
GGATGCGCCAGCCACTGAGCCTTCAGGGACCCAGCAGCCAGCCCCGTCTACAGAGAGCAGTGGCCTGGCACAGCCGGAGCATGGCCCCAA
CACAGACCTGCTTGGCACCTCACCCAAAGCCTCACTGGAACTGAAAAGCTCCATCATTGGCAAGAAGAAGCCAGCAGCAGCTAAGAAAGG
GCTGGGTGCCAAGAAAGGCCTAGGGGCCCAGAAGGTGAGCAGCCAGAGCTTCAGTGAGATTGAGCGGCAGGCTCAGGTGGCAGAGAAGCT
CCGTGAGCAGCAGGCAGCCGATGCCAAGAAGCAGGCGGAGGAGTCCATGGTCGCCTCCATGCGTCTGGCCTACCAGGAGCTCCAGATTGA
TCGTAAGAAAGAGGAAAAGAAGCTACAGAATCTGGAAGGGAAGAAGCGAGAGCAGGCAGAAAGGTTGGGCATGGGCTTGGTATCCCGAAG
CTCTGTCTCCCACTCCGTGCTGTCTGAGATGCAGGTGATTGAGCAGGAAACCCCAGTGAGTGCAAAATCCTCTCGCTCGCAGCTGGACTT
GTTTGACGATGTTGGTACTTTCGCCTCTGGACCCCCAAAGTACAAGGACAATCCCTTTTCCTTAGGGGAAAGCTTTGGCTCCCGCTGGGA
TACAGATGCTGCCTGGGGTATGGACAGGGTAGAGGAGAAGGAGCCAGAAGTGACCATCTCAAGCATCCGGCCTATTTCAGAAAGAGCCAC
AAACCGGAGGGAAGTGGAGAGCCGGAGCTCAGGCCTCGAGTCTAGTGAGGCGCGTCAGAAATTCGCAGGAGCCAAAGCCATCTCATCTGA
CATGTTCTTTGGGCGGGAGGTGGATGCAGAGTATGAGGCCAGGTCTCGGCTGCAGCAGCTCTCAGGCAGCAGTGCCATCAGCTCTTCAGA
CCTCTTTGGGGACATGGATGGAGCTCACGGAGCAGGAAGTGTATCTCTGGGGAACGTGCTGCCTACAGCGGACATTGCCCAGTTTAAGCA
GGGTGTCAAGTCTGTGGCTGGGAAAATGGCTGTGCTGGCCAATGGTGTGATGAATTCCTTGCAGGCATCCGTGGGCTCTGAGAAGCTCTT
TGCGCCGGGAACCGATAAAGGCCCAGCGCTTGAGAAGTCGGAGGCCAAGGCCGGGCCGGTGCCCAAGGTGTCAGGCCTGGAGCGCAGCCG
CGAGCTCAGCGCCGAGAGCTTCCTGCCCACTGCCAGCCCCGCGCCCCATGCCGCGCCCTGCCCGGGGCCCCCGCCCGGCTCCCGCGCCAA
TCCCTTGGTGAAGAAGGAACCCCCCGCCCCGCACCGCCACACCCCGCAGCCGCCACCCCCGCAGCCCCGCGGCCTGCTCCCGACACACGT
GCCTGCATCCCTGGGCGCCTTCGCGGGCCACAGCCAGGCGGCAGCCAACGGCCTGCACGGCCTCAGCAGGAGCAGCAGCGCCCCCCTGGG
CCTGGGGAAGCACGTGTCGCTGTCGCCACACGGGCCGGGCCCCCACCTGTCTACCTCACACCTGGCGCTCCGGTCCCAGGCGCAGCACCA
GCTCCACGCGGCCATGTTTGCCGCACCCCCGACACTGCCCCCGCCCCCGGCGCTGCCGGCCAGCAGCCTGGTCCTCCCAGGACACCCGGC
CGATCACGAGCTGCTCAGGCAAGAGCTGAACACGCGGTTTCTGGTGCAGAGCGCCGAGCGGCCTGGCGCCTCCCTGGGCCCGGGGGCTCT
GCTGCGGGCGGAGTTCCATCAGCACCAGCACACACACCAGCACACGCACCAACACACACACCAGCACCAACACACATTCGCCCCCTTCCC
CGCAGGGCTGCCCCCGACGCCGCCCGCCGCACCCCCGCCGTTTGACAAGTATGCGCCCAAGCTGGACAGCCCCTACTTCCGACATTCCAG
CGTGAGTTTCTTCCCGTCCTTCCCTCCTGCCATCCCGGGACTGCCCACCCTGCTCCCACACCCCGGCCCCTTCGGGTCCCTGCAGGGCGC
TTTTCAGCCTAAGGTGTCTGACCCGTACCGGGCGGTGGTCAAGGTGAGCACGTGTTGGGAAGGCCCGTGGCAAGGGAGGACTCTGGTGCC
CCCGGGGCGGCCTCGGGGGGCCCGTGACAGCAGGAGTCTGCAGAAAACATGGGTGGGGGTGGCACCAGCCCCACTGAGCGCTTCCATCCT
GTCGCAGAAGCCGGGGAGGTGGTGTGCCGTGCACGTGCAGATCGCCTGGCAGATCTACCGTCACCAGCAGAAGATAAAGGAGATGCAGCT
GGACCCCCACAAGCTGGAGGTGGGTGCAAAGCTGGACCTGTTCGGCAGACCCCCTGCCCCGGGCGTGTTTGCAGGCTTCCACTACCCACA
GGACCTGGCCCGGCCCCTCTTCCCCAGCACAGGTGCCGCCCATCCTGCCTCCAACCCATTTGGACCCTCAGCCCATCCTGGCAGCTTCCT
GCCCACTGGCCCCCTGACAGACCCTTTCAGCAGACCGAGCACCTTTGGGGGCCTGGGCAGCCTGAGCAGCCACGCCTTTGGGGGCCTGGG
CAGCCATGCACTGGCTCCCGGTGGCAGCATCTTTGCCCCCAAGGAGGGCTCCTCCGTGCACGGCCTGCCCAGCCCCCATGAGGCCTGGAA
CCGACTGCACCGGGCACCGCCCTCCTTCCCGGCTCCGCCCCCGTGGCCCAAGTCCGTGGACGCGGAGCGGGTGTCAGCCCTGACCAACCA
TGACCGAGAGCCGGACAATGGCAAGGAGGAGCAGGAACGGGACCTCCTGGAGAAGACGCGCCTGCTGAGCCGGGCCTCGCCCGCCACCCC
CGCTGGCCACCCCGTCAGCGGCCTCCTGCTCCGGGCCCAGAGCGAGCTGGGCCGGTCCGGGGCCCCCGCGGAGCGCGAGGCCGAACCTCG
GGTCAAGGAGAGCCGCTCCCCGGCCAAGGAGGAGGCCGCCAAGATGCCCGCGCGCGCATCCCCGCCCCACAGCAAGGCGGCCCCTGGAGA
CGTGAAGGTCAAGGAGGAGCGCGGGGAGGACGAGGCCTCCGAGCCCCCGGCGGGCGGCCTGCACCCCGCGCCCCTGCAGCTCGGCCTGGG
CCGCGAGCGCCTGGGCGCGCCGGGCTTCGCGTGGGAGCCTTTCCGCGGCCTGGAGCTGCCACGTCGCGCCTTCCCCGCTGCCGCCCCCGC
CCCGGGCTCCGCCGCCCTCTTGGAGCCCCCGGAGCGCCCCTACCGCGACCGCGAGCCCCACGGCTACAGCCCCGAGCGCCTGCGCGGGGA
GCTGGAGCGCGCGCGGGCCCCGCACCTGCCGCCCGCCGCCCCCGCCTTGGACGGCGCGCTGCTGCCCTCGCTGGGAGCCCTGCACTTCCC
GCGCCTCTCGCCCGCCGCGCTGCACAATGGGCTCCTGGCGCGGACCCCGCCCGCCGCCGCCGCCCTCGGCGCACCGCCCCCCCTGGTGAC
GGCGGCCGGGCCCCCCACGCCCCCCGGGCCGCCGCGGAGCCGGACTACTCCGCTGGGGGGCCTCGGGCCGGGCGAGGCGCGCGACTACTC

>5837_5837_3_ARFGAP2-FBRSL1_ARFGAP2_chr11_47187819_ENST00000524782_FBRSL1_chr12_133144067_ENST00000261673_length(amino acids)=1346AA_BP=512
MAAEPNKTEIQTLFKRLRAVPTNKACFDCGAKNPSWASITYGVFLCIDCSGVHRSLGVHLSFIRSTELDSNWNWFQLRCMQVGGNANATA
FFRQHGCTANDANTKYNSRAAQMYREKIRQLGSAALARHGTDLWIDNMSSAVPNHSPEKKDSDFFTEHTQPPAWDAPATEPSGTQQPAPS
TESSGLAQPEHGPNTDLLGTSPKASLELKSSIIGKKKPAAAKKGLGAKKGLGAQKVSSQSFSEIERQAQVAEKLREQQAADAKKQAEESM
VASMRLAYQELQIDRKKEEKKLQNLEGKKREQAERLGMGLVSRSSVSHSVLSEMQVIEQETPVSAKSSRSQLDLFDDVGTFASGPPKYKD
NPFSLGESFGSRWDTDAAWGMDRVEEKEPEVTISSIRPISERATNRREVESRSSGLESSEARQKFAGAKAISSDMFFGREVDAEYEARSR
LQQLSGSSAISSSDLFGDMDGAHGAGSVSLGNVLPTADIAQFKQGVKSVAGKMAVLANGVMNSLQASVGSEKLFAPGTDKGPALEKSEAK
AGPVPKVSGLERSRELSAESFLPTASPAPHAAPCPGPPPGSRANPLVKKEPPAPHRHTPQPPPPQPRGLLPTHVPASLGAFAGHSQAAAN
GLHGLSRSSSAPLGLGKHVSLSPHGPGPHLSTSHLALRSQAQHQLHAAMFAAPPTLPPPPALPASSLVLPGHPADHELLRQELNTRFLVQ
SAERPGASLGPGALLRAEFHQHQHTHQHTHQHTHQHQHTFAPFPAGLPPTPPAAPPPFDKYAPKLDSPYFRHSSVSFFPSFPPAIPGLPT
LLPHPGPFGSLQGAFQPKVSDPYRAVVKVSTCWEGPWQGRTLVPPGRPRGARDSRSLQKTWVGVAPAPLSASILSQKPGRWCAVHVQIAW
QIYRHQQKIKEMQLDPHKLEVGAKLDLFGRPPAPGVFAGFHYPQDLARPLFPSTGAAHPASNPFGPSAHPGSFLPTGPLTDPFSRPSTFG
GLGSLSSHAFGGLGSHALAPGGSIFAPKEGSSVHGLPSPHEAWNRLHRAPPSFPAPPPWPKSVDAERVSALTNHDREPDNGKEEQERDLL
EKTRLLSRASPATPAGHPVSGLLLRAQSELGRSGAPAEREAEPRVKESRSPAKEEAAKMPARASPPHSKAAPGDVKVKEERGEDEASEPP
AGGLHPAPLQLGLGRERLGAPGFAWEPFRGLELPRRAFPAAAPAPGSAALLEPPERPYRDREPHGYSPERLRGELERARAPHLPPAAPAL

--------------------------------------------------------------
>5837_5837_4_ARFGAP2-FBRSL1_ARFGAP2_chr11_47187819_ENST00000524782_FBRSL1_chr12_133144067_ENST00000434748_length(transcript)=5677nt_BP=1774nt
CCCGCCCCGGCTGCGGATTGGCCCGGCGCGGCGTTGATTCTTGCGGCCGCGGTTGTCGTCGCCGCCCCCGTCCCGCCGGCTGCCCATTGG
TCCAGATCGGACTCCAATCACCCCACCCCTCGGCTGGCCCAGGCACCGCTGAGGCCGGCCTGGTGAGCCCGCCCTCCCCGCCGTGGATTG
GCCCGCGGCGGGACCCGTCAGCCGCGGTTGTGTCTGGGAAGGAGAGAAAATGGCGGCGGAGCCGAACAAGACCGAAATCCAGACTCTTTT
TAAGAGGCTTCGCGCAGTTCCAACCAACAAGGCCTGTTTCGACTGCGGCGCCAAGAATCCGAGTTGGGCCAGCATCACGTACGGTGTTTT
CTTGTGCATTGACTGTTCCGGGGTGCACCGCTCCCTGGGCGTCCATCTGAGCTTCATCAGGTCCACAGAGTTGGATTCCAACTGGAACTG
GTTCCAGCTGAGGTGTATGCAGGTCGGCGGGAATGCCAATGCGACGGCTTTTTTTCGCCAACATGGATGCACAGCCAATGATGCCAACAC
CAAATATAATAGCCGAGCTGCCCAGATGTACCGGGAGAAGATCCGGCAGCTGGGGAGTGCGGCCCTGGCTAGGCATGGCACTGATCTTTG
GATAGACAACATGAGTAGTGCCGTTCCTAATCACTCCCCAGAGAAGAAGGACTCTGATTTCTTCACAGAACACACTCAACCCCCTGCCTG
GGATGCGCCAGCCACTGAGCCTTCAGGGACCCAGCAGCCAGCCCCGTCTACAGAGAGCAGTGGCCTGGCACAGCCGGAGCATGGCCCCAA
CACAGACCTGCTTGGCACCTCACCCAAAGCCTCACTGGAACTGAAAAGCTCCATCATTGGCAAGAAGAAGCCAGCAGCAGCTAAGAAAGG
GCTGGGTGCCAAGAAAGGCCTAGGGGCCCAGAAGGTGAGCAGCCAGAGCTTCAGTGAGATTGAGCGGCAGGCTCAGGTGGCAGAGAAGCT
CCGTGAGCAGCAGGCAGCCGATGCCAAGAAGCAGGCGGAGGAGTCCATGGTCGCCTCCATGCGTCTGGCCTACCAGGAGCTCCAGATTGA
TCGTAAGAAAGAGGAAAAGAAGCTACAGAATCTGGAAGGGAAGAAGCGAGAGCAGGCAGAAAGGTTGGGCATGGGCTTGGTATCCCGAAG
CTCTGTCTCCCACTCCGTGCTGTCTGAGATGCAGGTGATTGAGCAGGAAACCCCAGTGAGTGCAAAATCCTCTCGCTCGCAGCTGGACTT
GTTTGACGATGTTGGTACTTTCGCCTCTGGACCCCCAAAGTACAAGGACAATCCCTTTTCCTTAGGGGAAAGCTTTGGCTCCCGCTGGGA
TACAGATGCTGCCTGGGGTATGGACAGGGTAGAGGAGAAGGAGCCAGAAGTGACCATCTCAAGCATCCGGCCTATTTCAGAAAGAGCCAC
AAACCGGAGGGAAGTGGAGAGCCGGAGCTCAGGCCTCGAGTCTAGTGAGGCGCGTCAGAAATTCGCAGGAGCCAAAGCCATCTCATCTGA
CATGTTCTTTGGGCGGGAGGTGGATGCAGAGTATGAGGCCAGGTCTCGGCTGCAGCAGCTCTCAGGCAGCAGTGCCATCAGCTCTTCAGA
CCTCTTTGGGGACATGGATGGAGCTCACGGAGCAGGAAGTGTATCTCTGGGGAACGTGCTGCCTACAGCGGACATTGCCCAGTTTAAGCA
GGGTGTCAAGTCTGTGGCTGGGAAAATGGCTGTGCTGGCCAATGGTGTGATGAATTCCTTGCAGGCATCCGTGGGCTCTGAGAAGCTCTT
TGCGCCGGGAACCGATAAAGGCCCAGCGCTTGAGAAGTCGGAGGCCAAGGCCGGGCCGGTGCCCAAGGTGTCAGGCCTGGAGCGCAGCCG
CGAGCTCAGCGCCGAGAGCTTCCTGCCCACTGCCAGCCCCGCGCCCCATGCCGCGCCCTGCCCGGGGCCCCCGCCCGGCTCCCGCGCCAA
TCCCTTGGTGAAGAAGGAACCCCCCGCCCCGCACCGCCACACCCCGCAGCCGCCACCCCCGCAGCCCCGCGGCCTGCTCCCGACACACGT
GCCTGCATCCCTGGGCGCCTTCGCGGGCCACAGCCAGGCGGCAGCCAACGGCCTGCACGGCCTCAGCAGGAGCAGCAGCGCCCCCCTGGG
CCTGGGGAAGCACGTGTCGCTGTCGCCACACGGGCCGGGCCCCCACCTGTCTACCTCACACCTGGCGCTCCGGTCCCAGGCGCAGCACCA
GCTCCACGCGGCCATGTTTGCCGCACCCCCGACACTGCCCCCGCCCCCGGCGCTGCCGGCCAGCAGCCTGGTCCTCCCAGGACACCCGGC
CGATCACGAGCTGCTCAGGCAAGAGCTGAACACGCGGTTTCTGGTGCAGAGCGCCGAGCGGCCTGGCGCCTCCCTGGGCCCGGGGGCTCT
GCTGCGGGCGGAGTTCCATCAGCACCAGCACACACACCAGCACACGCACCAACACACACACCAGCACCAACACACATTCGCCCCCTTCCC
CGCAGGGCTGCCCCCGACGCCGCCCGCCGCACCCCCGCCGTTTGACAAGTATGCGCCCAAGCTGGACAGCCCCTACTTCCGACATTCCAG
CGTGAGTTTCTTCCCGTCCTTCCCTCCTGCCATCCCGGGACTGCCCACCCTGCTCCCACACCCCGGCCCCTTCGGGTCCCTGCAGGGCGC
TTTTCAGCCTAAGGTGTCTGACCCGTACCGGGCGGTGGTCAAGGTGAGCACGTGTTGGGAAGGCCCGTGGCAAGGGAGGACTCTGGTGCC
CCCGGGGCGGCCTCGGGGGGCCCGTGACAGCAGGAGTCTGCAGAAAACATGGGTGGGGGTGGCACCAGCCCCACTGAGCGCTTCCATCCT
GTCGCAGAAGCCGGGGAGGTGGTGTGCCGTGCACGTGCAGATCGCCTGGCAGATCTACCGTCACCAGCAGAAGATAAAGGAGATGCAGCT
GGACCCCCACAAGCTGGAGGTGGGTGCAAAGCTGGACCTGTTCGGCAGACCCCCTGCCCCGGGCGTGTTTGCAGGCTTCCACTACCCACA
GGACCTGGCCCGGCCCCTCTTCCCCAGCACAGGTGCCGCCCATCCTGCCTCCAACCCATTTGGACCCTCAGCCCATCCTGGCAGCTTCCT
GCCCACTGGCCCCCTGACAGACCCTTTCAGCAGACCGAGCACCTTTGGGGGCCTGGGCAGCCTGAGCAGCCACGCCTTTGGGGGCCTGGG
CAGCCATGCACTGGCTCCCGGTGGCAGCATCTTTGCCCCCAAGGAGGGCTCCTCCGTGCACGGCCTGCCCAGCCCCCATGAGGCCTGGAA
CCGACTGCACCGGGCACCGCCCTCCTTCCCGGCTCCGCCCCCGTGGCCCAAGTCCGTGGACGCGGAGCGGGTGTCAGCCCTGACCAACCA
TGACCGAGAGCCGGACAATGGCAAGGAGGAGCAGGAACGGGACCTCCTGGAGAAGACGCGCCTGCTGAGCCGGGCCTCGCCCGCCACCCC
CGCTGGCCACCCCGTCAGCGGCCTCCTGCTCCGGGCCCAGAGCGAGCTGGGCCGGTCCGGGGCCCCCGCGGAGCGCGAGGCCGAACCTCG
GGTCAAGGAGAGCCGCTCCCCGGCCAAGGAGGAGGCCGCCAAGATGCCCGCGCGCGCATCCCCGCCCCACAGCAAGGCGGCCCCTGGAGA
CGTGAAGGTCAAGGAGGAGCGCGGGGAGGACGAGGCCTCCGAGCCCCCGGCGGGCGGCCTGCACCCCGCGCCCCTGCAGCTCGGCCTGGG
CCGCGAGCGCCTGGGCGCGCCGGGCTTCGCGTGGGAGCCTTTCCGCGGCCTGGAGCTGCCACGTCGCGCCTTCCCCGCTGCCGCCCCCGC
CCCGGGCTCCGCCGCCCTCTTGGAGCCCCCGGAGCGCCCCTACCGCGACCGCGAGCCCCACGGCTACAGCCCCGAGCGCCTGCGCGGGGA
GCTGGAGCGCGCGCGGGCCCCGCACCTGCCGCCCGCCGCCCCCGCCTTGGACGGCGCGCTGCTGCCCTCGCTGGGAGCCCTGCACTTCCC
GCGCCTCTCGCCCGCCGCGCTGCACAATGGGCTCCTGGCGCGGACCCCGCCCGCCGCCGCCGCCCTCGGCGCACCGCCCCCCCTGGTGAC
GGCGGCCGGGCCCCCCACGCCCCCCGGGCCGCCGCGGAGCCGGACTACTCCGCTGGGGGGCCTCGGGCCGGGCGAGGCGCGCGACTACTC
CCCGTCCCGAAATCCCCCGGAGGTGGAGGCGCGGTAGCCCCGGGGCCGCAGACGCCTCTCCGAGCGGAGCGCACCGCTGTCCGTCTCTCC
ATCAGTTCCTAGAACTCAAGCACAGCTCCCGCCGATCCTGGGGCGGCGCCGCCTCTCCACCCGCAGCCTGCGGAGGCGGGGACTTGGGTG
TCGGCTTTTCTGAGGGTGATCTTTTGTTTTCCGAGTTTGGGATTCGGCTGTTGGGAAAAAAAAATCGCGTTTGTACCTTTTCCCCCCACA
GATGAGAAGTGTTTGTAATGGATTTGTATTTTTCTTAATTTTATGCTCTTTAGACGTTTAAAAGAACCAAAAAAGAAACTTTTGCTTCTT
CGTTTTCGGTTGGGATTTGCAGTTTAATGGCCTCAGATCCTTCTCCAGATCCCCAGGGTTTCTTTGTCTTATTTATGGAGAAAAACCGGT
CACTTTGTCCAGCGCACTGTGAGGCCCCCACTCAGGCCAGCCCTGGCCCCCCCTTGGTACTTGGAACCGAAGTTACAGATTATATTAAAA
TAATAATGTACAAAACTTTGTTTTTTTGCCTTATTATGCAGAAGTGTAATTTCTTTTTTGGTTTGTTTTTTTAAAAGCAAACGAAACGTG
TAAATAGTCTGTTGATATAAATATATGACGTTACTAAATTCTTAATCTAGATAGACTTTATAAAAACCGTTTCCAGAAACCCCTCTGGTT
GTTTGTCTAACATGGTCACAAAAACCCAGGCGCTGCTGGCTGTAAACATTATCAGAAGTTTAATGGCAGCAACTTTCCTTCAACTATGCA
AGCGCTTCCCGGCGGCTCTGCTGGTTGGGGGAGGAAGGTTCCGCCAGCGACCTCCCAGCCCCTGGGTCCGTGGAGGGGTTGGGTCCCCCA
GCAGAGCCCCTGGGCCAGCAGAACAGCACTCCTGGGCGGCTCCTGTGGGCTTCAGGACTGGCCGGCTCCAGCCGCAAGGGCGATGCTGTG
GACGTTTGTGTGGATGGTGCAGTGTTCTTGGAATCTGTAGACCAGATCGGTGGAGGTATAGAAGTGCAAGAGTCTAAAGGCTGATTTTAC
ACACACACACACACACACACACACACACACAAAATCACTGCTGTGTGTTTTCTTCCGCCTGAGGCATCAGCGTCACCTCGGTGTGGTCGT
CGCCTCCCAGGCCCTTGGCCTGGCCTCCTCTCAGTTTGGGTTTTGCCCTCACCCACATGAGCCCCCCCATGCCCTGCCCCCCTTGCGGCC
TTTTGTGTTCCCCGATGTCTGGGCTGTGTCCCTGCCGGGATTCCCAGCCTTCGGGGTCAGCCGTCGAGCCACTTGCTTTGCTCAGTTCTG
TGTTTCAGCCACATTTCCACGGTGGACCCTGTTTGTTTTAAATATTCTGTTCCCATGTCAATCAGTGACGATAAATACAGCCTTGATTTG

>5837_5837_4_ARFGAP2-FBRSL1_ARFGAP2_chr11_47187819_ENST00000524782_FBRSL1_chr12_133144067_ENST00000434748_length(amino acids)=1345AA_BP=512
MAAEPNKTEIQTLFKRLRAVPTNKACFDCGAKNPSWASITYGVFLCIDCSGVHRSLGVHLSFIRSTELDSNWNWFQLRCMQVGGNANATA
FFRQHGCTANDANTKYNSRAAQMYREKIRQLGSAALARHGTDLWIDNMSSAVPNHSPEKKDSDFFTEHTQPPAWDAPATEPSGTQQPAPS
TESSGLAQPEHGPNTDLLGTSPKASLELKSSIIGKKKPAAAKKGLGAKKGLGAQKVSSQSFSEIERQAQVAEKLREQQAADAKKQAEESM
VASMRLAYQELQIDRKKEEKKLQNLEGKKREQAERLGMGLVSRSSVSHSVLSEMQVIEQETPVSAKSSRSQLDLFDDVGTFASGPPKYKD
NPFSLGESFGSRWDTDAAWGMDRVEEKEPEVTISSIRPISERATNRREVESRSSGLESSEARQKFAGAKAISSDMFFGREVDAEYEARSR
LQQLSGSSAISSSDLFGDMDGAHGAGSVSLGNVLPTADIAQFKQGVKSVAGKMAVLANGVMNSLQASVGSEKLFAPGTDKGPALEKSEAK
AGPVPKVSGLERSRELSAESFLPTASPAPHAAPCPGPPPGSRANPLVKKEPPAPHRHTPQPPPPQPRGLLPTHVPASLGAFAGHSQAAAN
GLHGLSRSSSAPLGLGKHVSLSPHGPGPHLSTSHLALRSQAQHQLHAAMFAAPPTLPPPPALPASSLVLPGHPADHELLRQELNTRFLVQ
SAERPGASLGPGALLRAEFHQHQHTHQHTHQHTHQHQHTFAPFPAGLPPTPPAAPPPFDKYAPKLDSPYFRHSSVSFFPSFPPAIPGLPT
LLPHPGPFGSLQGAFQPKVSDPYRAVVKVSTCWEGPWQGRTLVPPGRPRGARDSRSLQKTWVGVAPAPLSASILSQKPGRWCAVHVQIAW
QIYRHQQKIKEMQLDPHKLEVGAKLDLFGRPPAPGVFAGFHYPQDLARPLFPSTGAAHPASNPFGPSAHPGSFLPTGPLTDPFSRPSTFG
GLGSLSSHAFGGLGSHALAPGGSIFAPKEGSSVHGLPSPHEAWNRLHRAPPSFPAPPPWPKSVDAERVSALTNHDREPDNGKEEQERDLL
EKTRLLSRASPATPAGHPVSGLLLRAQSELGRSGAPAEREAEPRVKESRSPAKEEAAKMPARASPPHSKAAPGDVKVKEERGEDEASEPP
AGGLHPAPLQLGLGRERLGAPGFAWEPFRGLELPRRAFPAAAPAPGSAALLEPPERPYRDREPHGYSPERLRGELERARAPHLPPAAPAL

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Fusion Gene PPI Analysis for ARFGAP2-FBRSL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARFGAP2-FBRSL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARFGAP2-FBRSL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARFGAP2C0024623Malignant neoplasm of stomach1CTD_human
HgeneARFGAP2C0038356Stomach Neoplasms1CTD_human
HgeneARFGAP2C0235874Disease Exacerbation1CTD_human
HgeneARFGAP2C1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneC0004238Atrial Fibrillation2CTD_human
TgeneC0235480Paroxysmal atrial fibrillation2CTD_human
TgeneC2585653Persistent atrial fibrillation2CTD_human
TgeneC3468561familial atrial fibrillation2CTD_human
TgeneC2931456Prostate cancer, familial1CTD_human
TgeneC4722327PROSTATE CANCER, HEREDITARY, 11CTD_human