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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CUL4A-TMCO3 (FusionGDB2 ID:HG8451TG55002)

Fusion Gene Summary for CUL4A-TMCO3

Fusion gene summary

Fusion gene information	Fusion gene name: CUL4A-TMCO3
	Fusion gene ID: hg8451tg55002
		Hgene	Tgene
	Gene symbol	CUL4A	TMCO3
	Gene ID	8451	55002
	Gene name	cullin 4A	transmembrane and coiled-coil domains 3
	Synonyms	-	C13orf11
	Cytomap	('CUL4A')('TMCO3') 13q34	13q34
	Type of gene	protein-coding	protein-coding
	Description	cullin-4ACUL-4A	transmembrane and coiled-coil domain-containing protein 3putative LAG1-interacting protein
	Modification date	20200327	20200313
	UniProtAcc	Q13619	.
	Ensembl transtripts involved in fusion gene	ENST00000463426, ENST00000375440, ENST00000326335, ENST00000375441, ENST00000451881,
Fusion gene scores	* DoF score	12 X 16 X 11=2112	15 X 14 X 11=2310
	# samples	19	24
	** MAII score	log2(19/2112*10)=-3.47453851102751 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(24/2310*10)=-3.2667865406949 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CUL4A [Title/Abstract] AND TMCO3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CUL4A(113909439)-TMCO3(114193672), # samples:1 CUL4A(113864402)-TMCO3(114188360), # samples:1
Anticipated loss of major functional domain due to fusion event.	CUL4A-TMCO3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CUL4A-TMCO3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CUL4A-TMCO3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CUL4A-TMCO3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CUL4A-TMCO3 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CUL4A	GO:0016567	protein ubiquitination	26431207

Fusion gene breakpoints across CUL4A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TMCO3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	CESC	TCGA-C5-A3HD-01B	CUL4A	chr13	113909439	+	TMCO3	chr13	114193672	+
ChimerDB4	CHOL	TCGA-3X-AAVE-01A	CUL4A	chr13	113864402	+	TMCO3	chr13	114188360	+

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Fusion Gene ORF analysis for CUL4A-TMCO3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000463426	ENST00000434316	CUL4A	chr13	113864402	+	TMCO3	chr13	114188360	+
3UTR-3UTR	ENST00000463426	ENST00000474393	CUL4A	chr13	113864402	+	TMCO3	chr13	114188360	+
3UTR-intron	ENST00000463426	ENST00000375391	CUL4A	chr13	113864402	+	TMCO3	chr13	114188360	+
5CDS-3UTR	ENST00000375440	ENST00000474393	CUL4A	chr13	113864402	+	TMCO3	chr13	114188360	+
5CDS-intron	ENST00000326335	ENST00000375391	CUL4A	chr13	113909439	+	TMCO3	chr13	114193672	+
5CDS-intron	ENST00000326335	ENST00000474393	CUL4A	chr13	113909439	+	TMCO3	chr13	114193672	+
5CDS-intron	ENST00000375440	ENST00000375391	CUL4A	chr13	113909439	+	TMCO3	chr13	114193672	+
5CDS-intron	ENST00000375440	ENST00000375391	CUL4A	chr13	113864402	+	TMCO3	chr13	114188360	+
5CDS-intron	ENST00000375440	ENST00000474393	CUL4A	chr13	113909439	+	TMCO3	chr13	114193672	+
5CDS-intron	ENST00000375441	ENST00000375391	CUL4A	chr13	113909439	+	TMCO3	chr13	114193672	+
5CDS-intron	ENST00000375441	ENST00000474393	CUL4A	chr13	113909439	+	TMCO3	chr13	114193672	+
5CDS-intron	ENST00000451881	ENST00000375391	CUL4A	chr13	113909439	+	TMCO3	chr13	114193672	+
5CDS-intron	ENST00000451881	ENST00000474393	CUL4A	chr13	113909439	+	TMCO3	chr13	114193672	+
5UTR-3CDS	ENST00000375441	ENST00000434316	CUL4A	chr13	113864402	+	TMCO3	chr13	114188360	+
5UTR-3CDS	ENST00000451881	ENST00000434316	CUL4A	chr13	113864402	+	TMCO3	chr13	114188360	+
5UTR-3UTR	ENST00000375441	ENST00000474393	CUL4A	chr13	113864402	+	TMCO3	chr13	114188360	+
5UTR-3UTR	ENST00000451881	ENST00000474393	CUL4A	chr13	113864402	+	TMCO3	chr13	114188360	+
5UTR-intron	ENST00000375441	ENST00000375391	CUL4A	chr13	113864402	+	TMCO3	chr13	114188360	+
5UTR-intron	ENST00000451881	ENST00000375391	CUL4A	chr13	113864402	+	TMCO3	chr13	114188360	+
Frame-shift	ENST00000375440	ENST00000434316	CUL4A	chr13	113864402	+	TMCO3	chr13	114188360	+
In-frame	ENST00000326335	ENST00000434316	CUL4A	chr13	113909439	+	TMCO3	chr13	114193672	+
In-frame	ENST00000375440	ENST00000434316	CUL4A	chr13	113909439	+	TMCO3	chr13	114193672	+
In-frame	ENST00000375441	ENST00000434316	CUL4A	chr13	113909439	+	TMCO3	chr13	114193672	+
In-frame	ENST00000451881	ENST00000434316	CUL4A	chr13	113909439	+	TMCO3	chr13	114193672	+
intron-3CDS	ENST00000326335	ENST00000434316	CUL4A	chr13	113864402	+	TMCO3	chr13	114188360	+
intron-3CDS	ENST00000463426	ENST00000434316	CUL4A	chr13	113909439	+	TMCO3	chr13	114193672	+
intron-3UTR	ENST00000326335	ENST00000474393	CUL4A	chr13	113864402	+	TMCO3	chr13	114188360	+
intron-intron	ENST00000326335	ENST00000375391	CUL4A	chr13	113864402	+	TMCO3	chr13	114188360	+
intron-intron	ENST00000463426	ENST00000375391	CUL4A	chr13	113909439	+	TMCO3	chr13	114193672	+
intron-intron	ENST00000463426	ENST00000474393	CUL4A	chr13	113909439	+	TMCO3	chr13	114193672	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000375441

CUL4A

chr13

113909439

ENST00000434316

TMCO3

chr13

114193672

3405

2253

381

2747

788

ENST00000451881

CUL4A

chr13

113909439

ENST00000434316

TMCO3

chr13

114193672

3132

1980

2474

814

ENST00000326335

CUL4A

chr13

113909439

ENST00000434316

TMCO3

chr13

114193672

3043

1891

160

2385

741

ENST00000375440

CUL4A

chr13

113909439

ENST00000434316

TMCO3

chr13

114193672

3267

2115

2609

841

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000375441	ENST00000434316	CUL4A	chr13	113909439	+	TMCO3	chr13	114193672	+	0.000818712	0.99918133
ENST00000451881	ENST00000434316	CUL4A	chr13	113909439	+	TMCO3	chr13	114193672	+	0.000605196	0.9993948
ENST00000326335	ENST00000434316	CUL4A	chr13	113909439	+	TMCO3	chr13	114193672	+	0.000581106	0.99941885
ENST00000375440	ENST00000434316	CUL4A	chr13	113909439	+	TMCO3	chr13	114193672	+	0.000346858	0.9996531

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Fusion Genomic Features for CUL4A-TMCO3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CUL4A	chr13	113909439	+	TMCO3	chr13	114193671	+	1.02E-05	0.99998987
CUL4A	chr13	113864402	+	TMCO3	chr13	114188359	+	5.74E-07	0.9999994
CUL4A	chr13	113909439	+	TMCO3	chr13	114193671	+	1.02E-05	0.99998987
CUL4A	chr13	113864402	+	TMCO3	chr13	114188359	+	5.74E-07	0.9999994

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CUL4A-TMCO3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:113909439/chr13:114193672)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CUL4A Q13619	.
FUNCTION: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL. The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207). With CUL4B, contributes to ribosome biogenesis (PubMed:26711351). {ECO:0000269\|PubMed:14578910, ECO:0000269\|PubMed:14609952, ECO:0000269\|PubMed:15448697, ECO:0000269\|PubMed:15548678, ECO:0000269\|PubMed:16537899, ECO:0000269\|PubMed:16678110, ECO:0000269\|PubMed:23478445, ECO:0000269\|PubMed:24209620, ECO:0000269\|PubMed:26431207, ECO:0000269\|PubMed:26711351}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TMCO3

chr13:113909439

chr13:114193672

ENST00000375391

124_204

415.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TMCO3

chr13:113909439

chr13:114193672

ENST00000375391

221_224

415.0

Compositional bias

Note=Poly-Glu

Tgene

TMCO3

chr13:113909439

chr13:114193672

ENST00000375391

286_306

415.0

Transmembrane

Helical

Tgene

TMCO3

chr13:113909439

chr13:114193672

ENST00000375391

317_337

415.0

Transmembrane

Helical

Tgene

TMCO3

chr13:113909439

chr13:114193672

ENST00000375391

350_370

415.0

Transmembrane

Helical

Tgene

TMCO3

chr13:113909439

chr13:114193672

ENST00000375391

416_436

415.0

Transmembrane

Helical

Tgene

TMCO3

chr13:113909439

chr13:114193672

ENST00000375391

456_476

415.0

Transmembrane

Helical

Tgene

TMCO3

chr13:113909439

chr13:114193672

ENST00000375391

498_518

415.0

Transmembrane

Helical

Tgene

TMCO3

chr13:113909439

chr13:114193672

ENST00000375391

554_574

415.0

Transmembrane

Helical

Tgene

TMCO3

chr13:113909439

chr13:114193672

ENST00000375391

578_598

415.0

Transmembrane

Helical

Tgene

TMCO3

chr13:113909439

chr13:114193672

ENST00000375391

608_628

415.0

Transmembrane

Helical

Tgene

TMCO3

chr13:113909439

chr13:114193672

ENST00000375391

640_660

415.0

Transmembrane

Helical

Tgene

TMCO3

chr13:113909439

chr13:114193672

ENST00000434316

554_574

513

678.0

Transmembrane

Helical

Tgene

TMCO3

chr13:113909439

chr13:114193672

ENST00000434316

578_598

513

678.0

Transmembrane

Helical

Tgene

TMCO3

chr13:113909439

chr13:114193672

ENST00000434316

608_628

513

678.0

Transmembrane

Helical

Tgene

TMCO3

chr13:113909439

chr13:114193672

ENST00000434316

640_660

513

678.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TMCO3

chr13:113909439

chr13:114193672

ENST00000434316

124_204

513

678.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TMCO3

chr13:113909439

chr13:114193672

ENST00000434316

221_224

513

678.0

Compositional bias

Note=Poly-Glu

Tgene

TMCO3

chr13:113909439

chr13:114193672

ENST00000434316

286_306

513

678.0

Transmembrane

Helical

Tgene

TMCO3

chr13:113909439

chr13:114193672

ENST00000434316

317_337

513

678.0

Transmembrane

Helical

Tgene

TMCO3

chr13:113909439

chr13:114193672

ENST00000434316

350_370

513

678.0

Transmembrane

Helical

Tgene

TMCO3

chr13:113909439

chr13:114193672

ENST00000434316

416_436

513

678.0

Transmembrane

Helical

Tgene

TMCO3

chr13:113909439

chr13:114193672

ENST00000434316

456_476

513

678.0

Transmembrane

Helical

Tgene

TMCO3

chr13:113909439

chr13:114193672

ENST00000434316

498_518

513

678.0

Transmembrane

Helical

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Fusion Gene Sequence for CUL4A-TMCO3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>20686_20686_1_CUL4A-TMCO3_CUL4A_chr13_113909439_ENST00000326335_TMCO3_chr13_114193672_ENST00000434316_length(transcript)=3043nt_BP=1891nt
GTCCTCTCAGCCGGGACGCCAGCGGCTCTGATTACAGACCTCGGCTGCCCGACAACTACACGCAGGACACGTGGCGGAAGCTGCACGAGG
CGGTGCGGGCCGTGCAGAGCAGCACCTCCATCAGGCTGTGGAAAATCTCTGTTCTCACAAAGTCTCCCCAATGCTCTACAAGCAACTGCG
TCAGGCCTGTGAAGACCACGTCCAGGCACAGATCCTTCCGTTTAGAGAAGACTCACTAGATAGTGTTTTATTTTTAAAGAAGATTAACAC
GTGCTGGCAGGACCACTGCAGACAAATGATCATGATCAGAAGCATCTTCCTGTTCTTGGACCGCACCTATGTGCTGCAGAACTCCACGCT
GCCCTCCATCTGGGATATGGGATTAGAACTGTTTAGAACCCATATTATTAGTGATAAAATGGTTCAGAGTAAAACCATTGATGGAATCCT
ACTGCTGATCGAGCGCGAGAGGAGCGGCGAGGCCGTGGACCGGAGCCTGTTGCGGAGCCTCCTGGGCATGCTGTCTGACCTGCAGGTGTA
TAAAGATTCATTTGAACTGAAATTTTTGGAAGAGACTAATTGCTTATATGCTGCCGAAGGCCAAAGGTTAATGCAGGAAAGAGAGGTTCC
AGAATATCTTAACCATGTAAGTAAACGCTTAGAGGAAGAGGGAGACAGAGTAATCACTTACTTGGACCACAGCACACAGAAACCACTGAT
TGCTTGTGTGGAGAAACAGCTATTAGGAGAACATTTAACAGCAATTCTGCAGAAAGGGCTCGACCACTTACTGGATGAGAACAGAGTGCC
GGACCTCGCACAGATGTACCAGCTGTTCAGCCGGGTGAGGGGCGGGCAGCAGGCGCTGCTGCAGCACTGGAGCGAGTACATCAAGACTTT
TGGAACAGCGATCGTAATCAATCCTGAGAAAGACAAAGACATGGTCCAAGACCTGTTGGACTTCAAGGACAAGGTGGACCACGTGATCGA
GGTCTGCTTCCAGAAGAATGAGCGGTTCGTCAACCTGATGAAGGAGTCCTTTGAGACGTTCATCAACAAGAGACCCAACAAGCCTGCAGA
ACTGATCGCAAAGCATGTGGATTCAAAGTTAAGAGCAGGCAACAAAGAAGCCACAGACGAGGAGCTGGAGCGGACGTTGGACAAGATCAT
GATCCTGTTCAGGTTTATCCACGGTAAAGATGTCTTTGAAGCATTTTATAAAAAAGATTTGGCAAAAAGACTCCTTGTTGGGAAAAGTGC
CTCAGTCGATGCTGAAAAGTCTATGTTGTCAAAGCTCAAGCATGAGTGCGGTGCAGCCTTCACCAGCAAGCTGGAAGGCATGTTCAAGGA
CATGGAGCTTTCGAAGGACATCATGGTTCATTTCAAGCAGCATATGCAGAATCAGAGTGACTCAGGCCCTATAGACCTCACAGTGAACAT
ACTCACAATGGGCTACTGGCCAACATACACGCCCATGGAAGTGCACTTAACCCCAGAAATGATTAAACTTCAGGAAGTATTTAAGGCATT
TTATCTTGGAAAGCACAGTGGTCGAAAACTTCAGTGGCAAACTACTTTGGGACATGCTGTTTTAAAAGCGGAGTTTAAAGAAGGGAAGAA
GGAATTCCAGGTGTCCCTCTTCCAGACACTGGTGCTCCTCATGTTCAACGAGGGAGATGGCTTCAGCTTTGAGGAGATAAAAATGGCCAC
GGGGATAGAGGATAGTGAATTGCGCAGAACGCTGCAGTCCCTGGCCTGTGGCAAAGCACGTGTGCTGATTAAAAGTCCCAAAGGAAAGGA
AGTGGAAGATGGAGACAAGTTCATTTTTAATGGAGAGTTCAAGCACAAGTTGTTTAGAATAAAGATCAATCAAATTCAGATGAAGGAAAC
TGTCACGGAGCTGCTGGACGTCTCCATGGAGCTGGGCTGTTTCCTGGCTGGAGCGCTCGTCTCCTCTCAGGGCCCCGTGGTCACCGAGGA
GATCGCCACCTCCATCGAACCCATCCGCGACTTCCTGGCCATCGTTTTCTTCGCCTCCATAGGGCTCCACGTGTTCCCCACGTTTGTGGC
GTACGAGCTCACGGTGCTGGTGTTCCTCACCTTGTCAGTGGTGGTGATGAAGTTTCTCCTGGCGGCGCTGGTCCTGTCTCTCATTCTGCC
GAGGAGCAGCCAGTACATCAAGTGGATCGTCTCTGCGGGGCTTGCCCAGGTCAGCGAGTTTTCCTTTGTCCTGGGGAGCCGGGCGCGAAG
AGCGGGCGTCATCTCTCGGGAGGTGTACCTCCTTATACTGAGTGTGACCACGCTCAGCCTCTTGCTCGCCCCGGTGCTGTGGAGAGCTGC
AATCACGAGGTGTGTGCCCAGACCGGAGAGACGGTCCAGCCTCTGATGGCTCGGAGATGATGGACCGTGGAAGGGAAGCGTCTGTGGGGA
GTGAGCGCTTAGATGGCCAGCAGCTGCTCCTTCTGGGAAGCTCGCACCTTGGCAACAGAACAGCCCTCTAGCAGAGCGTCAGTGCAGTCG
TGTTATCCCGGCTTTTACAGAATATTCTTGTCCTATTTTAGAATTTTCCGGAGTAGTTTATTTGCAGTCTGTTGATTATGTGCAGTAGAC
CCGGGACACTGCGTTTTACCGATCACCTTGAATGTGGTGCCTGGATGTGCCTTTTTTTTTTTTCCCTGAAATTATTATTAATTTTCTATT
GTGAGTTCATCAGTTCATAGTTTTTTTAGTAAAGAAGCAAAATTAAAAGGCTTTTAAAAATGTACAACTTCAGAATTATAATCTGTTAGT
CAAATATTTGTTATTAAACATTTCTGTAATATGAAGTTGTAATCCTGGCCGTGAGCTTGGAAGCTTACTTTTGATTCTTAAAGCCTATGT
TTTCTAAAATGAGACAAATACGGATGTCTATTTGCCTTTTATTGTAACTTTTAAATGAAATAATTTCATGTCAATTTCTATTAGATATAT
CACTTAAAATATTTGGTTTTAAATCACAAGAATATGTATTCTTTAATAAAGATAATTTATGATCATGGTATAA

>20686_20686_1_CUL4A-TMCO3_CUL4A_chr13_113909439_ENST00000326335_TMCO3_chr13_114193672_ENST00000434316_length(amino acids)=741AA_BP=0
MLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQS
KTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDH
STQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKD
KVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKR
LLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKL
QEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLI
KSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVTELLDVSMELGCFLAGALVSSQGPVVTEEIATSIEPIRDFLAIVFFASIGLH
VFPTFVAYELTVLVFLTLSVVVMKFLLAALVLSLILPRSSQYIKWIVSAGLAQVSEFSFVLGSRARRAGVISREVYLLILSVTTLSLLLA
PVLWRAAITRCVPRPERRSSL

--------------------------------------------------------------
>20686_20686_2_CUL4A-TMCO3_CUL4A_chr13_113909439_ENST00000375440_TMCO3_chr13_114193672_ENST00000434316_length(transcript)=3267nt_BP=2115nt
GGAGGCCGCGCGGACCGGGGCGGGCGGAGCGGAGCTCGGCGGGCGGCGGCGCTCGGGGCGGGGCGCGGCGGTTCCGGCCCAGCCATGGCG
GACGAGGCCCCGCGGAAGGGCAGCTTCTCGGCGCTCGTGGGCCGCACCAACGGCCTCACCAAGCCCGCGGCCCTGGCCGCCGCGCCCGCC
AAGCCGGGGGGCGCGGGCGGCTCCAAGAAGCTGGTCATCAAGAACTTCCGAGACAGACCTCGGCTGCCCGACAACTACACGCAGGACACG
TGGCGGAAGCTGCACGAGGCGGTGCGGGCCGTGCAGAGCAGCACCTCCATCAGGTACAACCTCGAGGAGCTCTACCAGGCTGTGGAAAAT
CTCTGTTCTCACAAAGTCTCCCCAATGCTCTACAAGCAACTGCGTCAGGCCTGTGAAGACCACGTCCAGGCACAGATCCTTCCGTTTAGA
GAAGACTCACTAGATAGTGTTTTATTTTTAAAGAAGATTAACACGTGCTGGCAGGACCACTGCAGACAAATGATCATGATCAGAAGCATC
TTCCTGTTCTTGGACCGCACCTATGTGCTGCAGAACTCCACGCTGCCCTCCATCTGGGATATGGGATTAGAACTGTTTAGAACCCATATT
ATTAGTGATAAAATGGTTCAGAGTAAAACCATTGATGGAATCCTACTGCTGATCGAGCGCGAGAGGAGCGGCGAGGCCGTGGACCGGAGC
CTGTTGCGGAGCCTCCTGGGCATGCTGTCTGACCTGCAGGTGTATAAAGATTCATTTGAACTGAAATTTTTGGAAGAGACTAATTGCTTA
TATGCTGCCGAAGGCCAAAGGTTAATGCAGGAAAGAGAGGTTCCAGAATATCTTAACCATGTAAGTAAACGCTTAGAGGAAGAGGGAGAC
AGAGTAATCACTTACTTGGACCACAGCACACAGAAACCACTGATTGCTTGTGTGGAGAAACAGCTATTAGGAGAACATTTAACAGCAATT
CTGCAGAAAGGGCTCGACCACTTACTGGATGAGAACAGAGTGCCGGACCTCGCACAGATGTACCAGCTGTTCAGCCGGGTGAGGGGCGGG
CAGCAGGCGCTGCTGCAGCACTGGAGCGAGTACATCAAGACTTTTGGAACAGCGATCGTAATCAATCCTGAGAAAGACAAAGACATGGTC
CAAGACCTGTTGGACTTCAAGGACAAGGTGGACCACGTGATCGAGGTCTGCTTCCAGAAGAATGAGCGGTTCGTCAACCTGATGAAGGAG
TCCTTTGAGACGTTCATCAACAAGAGACCCAACAAGCCTGCAGAACTGATCGCAAAGCATGTGGATTCAAAGTTAAGAGCAGGCAACAAA
GAAGCCACAGACGAGGAGCTGGAGCGGACGTTGGACAAGATCATGATCCTGTTCAGGTTTATCCACGGTAAAGATGTCTTTGAAGCATTT
TATAAAAAAGATTTGGCAAAAAGACTCCTTGTTGGGAAAAGTGCCTCAGTCGATGCTGAAAAGTCTATGTTGTCAAAGCTCAAGCATGAG
TGCGGTGCAGCCTTCACCAGCAAGCTGGAAGGCATGTTCAAGGACATGGAGCTTTCGAAGGACATCATGGTTCATTTCAAGCAGCATATG
CAGAATCAGAGTGACTCAGGCCCTATAGACCTCACAGTGAACATACTCACAATGGGCTACTGGCCAACATACACGCCCATGGAAGTGCAC
TTAACCCCAGAAATGATTAAACTTCAGGAAGTATTTAAGGCATTTTATCTTGGAAAGCACAGTGGTCGAAAACTTCAGTGGCAAACTACT
TTGGGACATGCTGTTTTAAAAGCGGAGTTTAAAGAAGGGAAGAAGGAATTCCAGGTGTCCCTCTTCCAGACACTGGTGCTCCTCATGTTC
AACGAGGGAGATGGCTTCAGCTTTGAGGAGATAAAAATGGCCACGGGGATAGAGGATAGTGAATTGCGCAGAACGCTGCAGTCCCTGGCC
TGTGGCAAAGCACGTGTGCTGATTAAAAGTCCCAAAGGAAAGGAAGTGGAAGATGGAGACAAGTTCATTTTTAATGGAGAGTTCAAGCAC
AAGTTGTTTAGAATAAAGATCAATCAAATTCAGATGAAGGAAACTGTCACGGAGCTGCTGGACGTCTCCATGGAGCTGGGCTGTTTCCTG
GCTGGAGCGCTCGTCTCCTCTCAGGGCCCCGTGGTCACCGAGGAGATCGCCACCTCCATCGAACCCATCCGCGACTTCCTGGCCATCGTT
TTCTTCGCCTCCATAGGGCTCCACGTGTTCCCCACGTTTGTGGCGTACGAGCTCACGGTGCTGGTGTTCCTCACCTTGTCAGTGGTGGTG
ATGAAGTTTCTCCTGGCGGCGCTGGTCCTGTCTCTCATTCTGCCGAGGAGCAGCCAGTACATCAAGTGGATCGTCTCTGCGGGGCTTGCC
CAGGTCAGCGAGTTTTCCTTTGTCCTGGGGAGCCGGGCGCGAAGAGCGGGCGTCATCTCTCGGGAGGTGTACCTCCTTATACTGAGTGTG
ACCACGCTCAGCCTCTTGCTCGCCCCGGTGCTGTGGAGAGCTGCAATCACGAGGTGTGTGCCCAGACCGGAGAGACGGTCCAGCCTCTGA
TGGCTCGGAGATGATGGACCGTGGAAGGGAAGCGTCTGTGGGGAGTGAGCGCTTAGATGGCCAGCAGCTGCTCCTTCTGGGAAGCTCGCA
CCTTGGCAACAGAACAGCCCTCTAGCAGAGCGTCAGTGCAGTCGTGTTATCCCGGCTTTTACAGAATATTCTTGTCCTATTTTAGAATTT
TCCGGAGTAGTTTATTTGCAGTCTGTTGATTATGTGCAGTAGACCCGGGACACTGCGTTTTACCGATCACCTTGAATGTGGTGCCTGGAT
GTGCCTTTTTTTTTTTTCCCTGAAATTATTATTAATTTTCTATTGTGAGTTCATCAGTTCATAGTTTTTTTAGTAAAGAAGCAAAATTAA
AAGGCTTTTAAAAATGTACAACTTCAGAATTATAATCTGTTAGTCAAATATTTGTTATTAAACATTTCTGTAATATGAAGTTGTAATCCT
GGCCGTGAGCTTGGAAGCTTACTTTTGATTCTTAAAGCCTATGTTTTCTAAAATGAGACAAATACGGATGTCTATTTGCCTTTTATTGTA
ACTTTTAAATGAAATAATTTCATGTCAATTTCTATTAGATATATCACTTAAAATATTTGGTTTTAAATCACAAGAATATGTATTCTTTAA
TAAAGATAATTTATGATCATGGTATAA

>20686_20686_2_CUL4A-TMCO3_CUL4A_chr13_113909439_ENST00000375440_TMCO3_chr13_114193672_ENST00000434316_length(amino acids)=841AA_BP=0
MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAV
ENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRT
HIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEE
GDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKD
MVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFE
AFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPME
VHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQS
LACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVTELLDVSMELGCFLAGALVSSQGPVVTEEIATSIEPIRDFLA
IVFFASIGLHVFPTFVAYELTVLVFLTLSVVVMKFLLAALVLSLILPRSSQYIKWIVSAGLAQVSEFSFVLGSRARRAGVISREVYLLIL
SVTTLSLLLAPVLWRAAITRCVPRPERRSSL

--------------------------------------------------------------
>20686_20686_3_CUL4A-TMCO3_CUL4A_chr13_113909439_ENST00000375441_TMCO3_chr13_114193672_ENST00000434316_length(transcript)=3405nt_BP=2253nt
ACCGCCCACAGCGGGCCCTCGGCGTGGCCCGCAGGCCCTTCGGACCGCCTGGGAGCGCGGCCACACGTGCCAGCAAGTGAGGGCAGCGAC
CTGGGACCGCCGCGTCTACTTACACCGCGACGACTCCGCGATCCACGGACACCGCCCGGCCCCCACGGCGGCCCTGCAGGGGAGAACTCG
GGCCGCCTTCCCGAGTCCCGGCCGCCGCTGTTCGGCTCGCGCGGCTGCCCGCCGGGGACCCGAACGGAAGAAGGGTGGCGAGGCGGGAAA
GGAAAAGGCCTGAGGGTCCAAGGCAGGAGGGGACACACGGAACACGCCGAGGGCCAACCACGCCGCCGCGCGCTCCCCGGCTAGGACCCA
CCTGCTGCAGACAGACCTCGGCTGCCCGACAACTACACGCAGGACACGTGGCGGAAGCTGCACGAGGCGGTGCGGGCCGTGCAGAGCAGC
ACCTCCATCAGGTACAACCTCGAGGAGCTCTACCAGGCTGTGGAAAATCTCTGTTCTCACAAAGTCTCCCCAATGCTCTACAAGCAACTG
CGTCAGGCCTGTGAAGACCACGTCCAGGCACAGATCCTTCCGTTTAGAGAAGACTCACTAGATAGTGTTTTATTTTTAAAGAAGATTAAC
ACGTGCTGGCAGGACCACTGCAGACAAATGATCATGATCAGAAGCATCTTCCTGTTCTTGGACCGCACCTATGTGCTGCAGAACTCCACG
CTGCCCTCCATCTGGGATATGGGATTAGAACTGTTTAGAACCCATATTATTAGTGATAAAATGGTTCAGAGTAAAACCATTGATGGAATC
CTACTGCTGATCGAGCGCGAGAGGAGCGGCGAGGCCGTGGACCGGAGCCTGTTGCGGAGCCTCCTGGGCATGCTGTCTGACCTGCAGGTG
TATAAAGATTCATTTGAACTGAAATTTTTGGAAGAGACTAATTGCTTATATGCTGCCGAAGGCCAAAGGTTAATGCAGGAAAGAGAGGTT
CCAGAATATCTTAACCATGTAAGTAAACGCTTAGAGGAAGAGGGAGACAGAGTAATCACTTACTTGGACCACAGCACACAGAAACCACTG
ATTGCTTGTGTGGAGAAACAGCTATTAGGAGAACATTTAACAGCAATTCTGCAGAAAGGGCTCGACCACTTACTGGATGAGAACAGAGTG
CCGGACCTCGCACAGATGTACCAGCTGTTCAGCCGGGTGAGGGGCGGGCAGCAGGCGCTGCTGCAGCACTGGAGCGAGTACATCAAGACT
TTTGGAACAGCGATCGTAATCAATCCTGAGAAAGACAAAGACATGGTCCAAGACCTGTTGGACTTCAAGGACAAGGTGGACCACGTGATC
GAGGTCTGCTTCCAGAAGAATGAGCGGTTCGTCAACCTGATGAAGGAGTCCTTTGAGACGTTCATCAACAAGAGACCCAACAAGCCTGCA
GAACTGATCGCAAAGCATGTGGATTCAAAGTTAAGAGCAGGCAACAAAGAAGCCACAGACGAGGAGCTGGAGCGGACGTTGGACAAGATC
ATGATCCTGTTCAGGTTTATCCACGGTAAAGATGTCTTTGAAGCATTTTATAAAAAAGATTTGGCAAAAAGACTCCTTGTTGGGAAAAGT
GCCTCAGTCGATGCTGAAAAGTCTATGTTGTCAAAGCTCAAGCATGAGTGCGGTGCAGCCTTCACCAGCAAGCTGGAAGGCATGTTCAAG
GACATGGAGCTTTCGAAGGACATCATGGTTCATTTCAAGCAGCATATGCAGAATCAGAGTGACTCAGGCCCTATAGACCTCACAGTGAAC
ATACTCACAATGGGCTACTGGCCAACATACACGCCCATGGAAGTGCACTTAACCCCAGAAATGATTAAACTTCAGGAAGTATTTAAGGCA
TTTTATCTTGGAAAGCACAGTGGTCGAAAACTTCAGTGGCAAACTACTTTGGGACATGCTGTTTTAAAAGCGGAGTTTAAAGAAGGGAAG
AAGGAATTCCAGGTGTCCCTCTTCCAGACACTGGTGCTCCTCATGTTCAACGAGGGAGATGGCTTCAGCTTTGAGGAGATAAAAATGGCC
ACGGGGATAGAGGATAGTGAATTGCGCAGAACGCTGCAGTCCCTGGCCTGTGGCAAAGCACGTGTGCTGATTAAAAGTCCCAAAGGAAAG
GAAGTGGAAGATGGAGACAAGTTCATTTTTAATGGAGAGTTCAAGCACAAGTTGTTTAGAATAAAGATCAATCAAATTCAGATGAAGGAA
ACTGTCACGGAGCTGCTGGACGTCTCCATGGAGCTGGGCTGTTTCCTGGCTGGAGCGCTCGTCTCCTCTCAGGGCCCCGTGGTCACCGAG
GAGATCGCCACCTCCATCGAACCCATCCGCGACTTCCTGGCCATCGTTTTCTTCGCCTCCATAGGGCTCCACGTGTTCCCCACGTTTGTG
GCGTACGAGCTCACGGTGCTGGTGTTCCTCACCTTGTCAGTGGTGGTGATGAAGTTTCTCCTGGCGGCGCTGGTCCTGTCTCTCATTCTG
CCGAGGAGCAGCCAGTACATCAAGTGGATCGTCTCTGCGGGGCTTGCCCAGGTCAGCGAGTTTTCCTTTGTCCTGGGGAGCCGGGCGCGA
AGAGCGGGCGTCATCTCTCGGGAGGTGTACCTCCTTATACTGAGTGTGACCACGCTCAGCCTCTTGCTCGCCCCGGTGCTGTGGAGAGCT
GCAATCACGAGGTGTGTGCCCAGACCGGAGAGACGGTCCAGCCTCTGATGGCTCGGAGATGATGGACCGTGGAAGGGAAGCGTCTGTGGG
GAGTGAGCGCTTAGATGGCCAGCAGCTGCTCCTTCTGGGAAGCTCGCACCTTGGCAACAGAACAGCCCTCTAGCAGAGCGTCAGTGCAGT
CGTGTTATCCCGGCTTTTACAGAATATTCTTGTCCTATTTTAGAATTTTCCGGAGTAGTTTATTTGCAGTCTGTTGATTATGTGCAGTAG
ACCCGGGACACTGCGTTTTACCGATCACCTTGAATGTGGTGCCTGGATGTGCCTTTTTTTTTTTTCCCTGAAATTATTATTAATTTTCTA
TTGTGAGTTCATCAGTTCATAGTTTTTTTAGTAAAGAAGCAAAATTAAAAGGCTTTTAAAAATGTACAACTTCAGAATTATAATCTGTTA
GTCAAATATTTGTTATTAAACATTTCTGTAATATGAAGTTGTAATCCTGGCCGTGAGCTTGGAAGCTTACTTTTGATTCTTAAAGCCTAT
GTTTTCTAAAATGAGACAAATACGGATGTCTATTTGCCTTTTATTGTAACTTTTAAATGAAATAATTTCATGTCAATTTCTATTAGATAT
ATCACTTAAAATATTTGGTTTTAAATCACAAGAATATGTATTCTTTAATAAAGATAATTTATGATCATGGTATAA

>20686_20686_3_CUL4A-TMCO3_CUL4A_chr13_113909439_ENST00000375441_TMCO3_chr13_114193672_ENST00000434316_length(amino acids)=788AA_BP=1
MPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHC
RQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFEL
KFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMY
QLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHV
DSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKD
IMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSL
FQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVTELLD
VSMELGCFLAGALVSSQGPVVTEEIATSIEPIRDFLAIVFFASIGLHVFPTFVAYELTVLVFLTLSVVVMKFLLAALVLSLILPRSSQYI
KWIVSAGLAQVSEFSFVLGSRARRAGVISREVYLLILSVTTLSLLLAPVLWRAAITRCVPRPERRSSL

--------------------------------------------------------------
>20686_20686_4_CUL4A-TMCO3_CUL4A_chr13_113909439_ENST00000451881_TMCO3_chr13_114193672_ENST00000434316_length(transcript)=3132nt_BP=1980nt
CCTGGGGACCGGCTCGGCGACGCGCTCGGGCTGAGGGGGCCCGGGGTCTTTCTGCCGGGGCCCCGTCCTCTCAGCCGGGACGCCAGCGGC
TCTGATTACAGACCTCGGCTGCCCGACAACTACACGCAGGACACGTGGCGGAAGCTGCACGAGGCGGTGCGGGCCGTGCAGAGCAGCACC
TCCATCAGGTACAACCTCGAGGAGCTCTACCAGGCTGTGGAAAATCTCTGTTCTCACAAAGTCTCCCCAATGCTCTACAAGCAACTGCGT
CAGGCCTGTGAAGACCACGTCCAGGCACAGATCCTTCCGTTTAGAGAAGACTCACTAGATAGTGTTTTATTTTTAAAGAAGATTAACACG
TGCTGGCAGGACCACTGCAGACAAATGATCATGATCAGAAGCATCTTCCTGTTCTTGGACCGCACCTATGTGCTGCAGAACTCCACGCTG
CCCTCCATCTGGGATATGGGATTAGAACTGTTTAGAACCCATATTATTAGTGATAAAATGGTTCAGAGTAAAACCATTGATGGAATCCTA
CTGCTGATCGAGCGCGAGAGGAGCGGCGAGGCCGTGGACCGGAGCCTGTTGCGGAGCCTCCTGGGCATGCTGTCTGACCTGCAGGTGTAT
AAAGATTCATTTGAACTGAAATTTTTGGAAGAGACTAATTGCTTATATGCTGCCGAAGGCCAAAGGTTAATGCAGGAAAGAGAGGTTCCA
GAATATCTTAACCATGTAAGTAAACGCTTAGAGGAAGAGGGAGACAGAGTAATCACTTACTTGGACCACAGCACACAGAAACCACTGATT
GCTTGTGTGGAGAAACAGCTATTAGGAGAACATTTAACAGCAATTCTGCAGAAAGGGCTCGACCACTTACTGGATGAGAACAGAGTGCCG
GACCTCGCACAGATGTACCAGCTGTTCAGCCGGGTGAGGGGCGGGCAGCAGGCGCTGCTGCAGCACTGGAGCGAGTACATCAAGACTTTT
GGAACAGCGATCGTAATCAATCCTGAGAAAGACAAAGACATGGTCCAAGACCTGTTGGACTTCAAGGACAAGGTGGACCACGTGATCGAG
GTCTGCTTCCAGAAGAATGAGCGGTTCGTCAACCTGATGAAGGAGTCCTTTGAGACGTTCATCAACAAGAGACCCAACAAGCCTGCAGAA
CTGATCGCAAAGCATGTGGATTCAAAGTTAAGAGCAGGCAACAAAGAAGCCACAGACGAGGAGCTGGAGCGGACGTTGGACAAGATCATG
ATCCTGTTCAGGTTTATCCACGGTAAAGATGTCTTTGAAGCATTTTATAAAAAAGATTTGGCAAAAAGACTCCTTGTTGGGAAAAGTGCC
TCAGTCGATGCTGAAAAGTCTATGTTGTCAAAGCTCAAGCATGAGTGCGGTGCAGCCTTCACCAGCAAGCTGGAAGGCATGTTCAAGGAC
ATGGAGCTTTCGAAGGACATCATGGTTCATTTCAAGCAGCATATGCAGAATCAGAGTGACTCAGGCCCTATAGACCTCACAGTGAACATA
CTCACAATGGGCTACTGGCCAACATACACGCCCATGGAAGTGCACTTAACCCCAGAAATGATTAAACTTCAGGAAGTATTTAAGGCATTT
TATCTTGGAAAGCACAGTGGTCGAAAACTTCAGTGGCAAACTACTTTGGGACATGCTGTTTTAAAAGCGGAGTTTAAAGAAGGGAAGAAG
GAATTCCAGGTGTCCCTCTTCCAGACACTGGTGCTCCTCATGTTCAACGAGGGAGATGGCTTCAGCTTTGAGGAGATAAAAATGGCCACG
GGGATAGAGGATAGTGAATTGCGCAGAACGCTGCAGTCCCTGGCCTGTGGCAAAGCACGTGTGCTGATTAAAAGTCCCAAAGGAAAGGAA
GTGGAAGATGGAGACAAGTTCATTTTTAATGGAGAGTTCAAGCACAAGTTGTTTAGAATAAAGATCAATCAAATTCAGATGAAGGAAACT
GTCACGGAGCTGCTGGACGTCTCCATGGAGCTGGGCTGTTTCCTGGCTGGAGCGCTCGTCTCCTCTCAGGGCCCCGTGGTCACCGAGGAG
ATCGCCACCTCCATCGAACCCATCCGCGACTTCCTGGCCATCGTTTTCTTCGCCTCCATAGGGCTCCACGTGTTCCCCACGTTTGTGGCG
TACGAGCTCACGGTGCTGGTGTTCCTCACCTTGTCAGTGGTGGTGATGAAGTTTCTCCTGGCGGCGCTGGTCCTGTCTCTCATTCTGCCG
AGGAGCAGCCAGTACATCAAGTGGATCGTCTCTGCGGGGCTTGCCCAGGTCAGCGAGTTTTCCTTTGTCCTGGGGAGCCGGGCGCGAAGA
GCGGGCGTCATCTCTCGGGAGGTGTACCTCCTTATACTGAGTGTGACCACGCTCAGCCTCTTGCTCGCCCCGGTGCTGTGGAGAGCTGCA
ATCACGAGGTGTGTGCCCAGACCGGAGAGACGGTCCAGCCTCTGATGGCTCGGAGATGATGGACCGTGGAAGGGAAGCGTCTGTGGGGAG
TGAGCGCTTAGATGGCCAGCAGCTGCTCCTTCTGGGAAGCTCGCACCTTGGCAACAGAACAGCCCTCTAGCAGAGCGTCAGTGCAGTCGT
GTTATCCCGGCTTTTACAGAATATTCTTGTCCTATTTTAGAATTTTCCGGAGTAGTTTATTTGCAGTCTGTTGATTATGTGCAGTAGACC
CGGGACACTGCGTTTTACCGATCACCTTGAATGTGGTGCCTGGATGTGCCTTTTTTTTTTTTCCCTGAAATTATTATTAATTTTCTATTG
TGAGTTCATCAGTTCATAGTTTTTTTAGTAAAGAAGCAAAATTAAAAGGCTTTTAAAAATGTACAACTTCAGAATTATAATCTGTTAGTC
AAATATTTGTTATTAAACATTTCTGTAATATGAAGTTGTAATCCTGGCCGTGAGCTTGGAAGCTTACTTTTGATTCTTAAAGCCTATGTT
TTCTAAAATGAGACAAATACGGATGTCTATTTGCCTTTTATTGTAACTTTTAAATGAAATAATTTCATGTCAATTTCTATTAGATATATC
ACTTAAAATATTTGGTTTTAAATCACAAGAATATGTATTCTTTAATAAAGATAATTTATGATCATGGTATAA

>20686_20686_4_CUL4A-TMCO3_CUL4A_chr13_113909439_ENST00000451881_TMCO3_chr13_114193672_ENST00000434316_length(amino acids)=814AA_BP=1
MRGPGVFLPGPRPLSRDASGSDYRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQ
ILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGE
AVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGE
HLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFV
NLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLS
KLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKL
QWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFN
GEFKHKLFRIKINQIQMKETVTELLDVSMELGCFLAGALVSSQGPVVTEEIATSIEPIRDFLAIVFFASIGLHVFPTFVAYELTVLVFLT
LSVVVMKFLLAALVLSLILPRSSQYIKWIVSAGLAQVSEFSFVLGSRARRAGVISREVYLLILSVTTLSLLLAPVLWRAAITRCVPRPER
RSSL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CUL4A-TMCO3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CUL4A-TMCO3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CUL4A-TMCO3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	CUL4A	C0004238	Atrial Fibrillation	2	CTD_human
Hgene	CUL4A	C0235480	Paroxysmal atrial fibrillation	2	CTD_human
Hgene	CUL4A	C2585653	Persistent atrial fibrillation	2	CTD_human
Hgene	CUL4A	C3468561	familial atrial fibrillation	2	CTD_human
Hgene	CUL4A	C0014518	Toxic Epidermal Necrolysis	1	CTD_human
Hgene	CUL4A	C0038325	Stevens-Johnson Syndrome	1	CTD_human
Hgene	CUL4A	C1274933	Drug-Induced Stevens Johnson Syndrome	1	CTD_human
Hgene	CUL4A	C3658301	Mycoplasma-Induced Stevens-Johnson Syndrome	1	CTD_human
Hgene	CUL4A	C3658302	Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:CUL4A-TMCO3 (FusionGDB2 ID:HG8451TG55002)

Fusion Gene Summary for CUL4A-TMCO3

Fusion Gene ORF analysis for CUL4A-TMCO3

Fusion Genomic Features for CUL4A-TMCO3

Fusion Protein Features for CUL4A-TMCO3

Fusion Gene Sequence for CUL4A-TMCO3

Fusion Gene PPI Analysis for CUL4A-TMCO3

Related Drugs for CUL4A-TMCO3

Related Diseases for CUL4A-TMCO3

Fusion Gene Studies
in Kim Lab