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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:CUL3-AP1S3 (FusionGDB2 ID:HG8452TG130340) |
Fusion Gene Summary for CUL3-AP1S3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CUL3-AP1S3 | Fusion gene ID: hg8452tg130340 | Hgene | Tgene | Gene symbol | CUL3 | AP1S3 | Gene ID | 8452 | 130340 |
| Gene name | cullin 3 | adaptor related protein complex 1 subunit sigma 3 | |
| Synonyms | CUL-3|PHA2E | PSORS15 | |
| Cytomap | ('CUL3')('AP1S3') 2q36.2 | 2q36.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cullin-3 | AP-1 complex subunit sigma-3adapter-related protein complex 1 subunit sigma-1Cadaptor protein complex AP-1 sigma-1C subunitadaptor related protein complex 1 sigma 3 subunitadaptor-related protein complex 1 subunit sigma-1Cclathrin assembly protein co | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | . | Q96PC3 | |
| Ensembl transtripts involved in fusion gene | ENST00000432260, ENST00000409777, ENST00000264414, ENST00000344951, ENST00000409096, | ||
| Fusion gene scores | * DoF score | 12 X 12 X 7=1008 | 4 X 2 X 3=24 |
| # samples | 14 | 5 | |
| ** MAII score | log2(14/1008*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/24*10)=1.05889368905357 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CUL3 [Title/Abstract] AND AP1S3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | CUL3(225400245)-AP1S3(224642586), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | CUL3-AP1S3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CUL3-AP1S3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CUL3-AP1S3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. CUL3-AP1S3 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CUL3 | GO:0000209 | protein polyubiquitination | 19261606 |
| Hgene | CUL3 | GO:0006511 | ubiquitin-dependent protein catabolic process | 25401743|27561354 |
| Hgene | CUL3 | GO:0006513 | protein monoubiquitination | 22358839 |
| Hgene | CUL3 | GO:0006888 | ER to Golgi vesicle-mediated transport | 22358839 |
| Hgene | CUL3 | GO:0016567 | protein ubiquitination | 17543862|19782033|19995937|20389280|23213400 |
| Hgene | CUL3 | GO:0031145 | anaphase-promoting complex-dependent catabolic process | 10500095 |
| Hgene | CUL3 | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 19261606|19782033|20389280 |
| Hgene | CUL3 | GO:0071630 | nuclear protein quality control by the ubiquitin-proteasome system | 27561354 |
| Fusion gene breakpoints across CUL3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across AP1S3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-BR-8078-01A | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - |
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Fusion Gene ORF analysis for CUL3-AP1S3 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000432260 | ENST00000396653 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - |
| 5UTR-3CDS | ENST00000432260 | ENST00000396654 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - |
| 5UTR-3CDS | ENST00000432260 | ENST00000409375 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - |
| 5UTR-3CDS | ENST00000432260 | ENST00000423110 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - |
| 5UTR-3CDS | ENST00000432260 | ENST00000443700 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - |
| 5UTR-3CDS | ENST00000432260 | ENST00000446015 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - |
| Frame-shift | ENST00000409777 | ENST00000396653 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - |
| Frame-shift | ENST00000409777 | ENST00000396654 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - |
| Frame-shift | ENST00000409777 | ENST00000409375 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - |
| Frame-shift | ENST00000409777 | ENST00000423110 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - |
| Frame-shift | ENST00000409777 | ENST00000443700 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - |
| Frame-shift | ENST00000409777 | ENST00000446015 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - |
| In-frame | ENST00000264414 | ENST00000396653 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - |
| In-frame | ENST00000264414 | ENST00000396654 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - |
| In-frame | ENST00000264414 | ENST00000409375 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - |
| In-frame | ENST00000264414 | ENST00000423110 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - |
| In-frame | ENST00000264414 | ENST00000443700 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - |
| In-frame | ENST00000264414 | ENST00000446015 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - |
| In-frame | ENST00000344951 | ENST00000396653 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - |
| In-frame | ENST00000344951 | ENST00000396654 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - |
| In-frame | ENST00000344951 | ENST00000409375 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - |
| In-frame | ENST00000344951 | ENST00000423110 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - |
| In-frame | ENST00000344951 | ENST00000443700 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - |
| In-frame | ENST00000344951 | ENST00000446015 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - |
| In-frame | ENST00000409096 | ENST00000396653 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - |
| In-frame | ENST00000409096 | ENST00000396654 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - |
| In-frame | ENST00000409096 | ENST00000409375 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - |
| In-frame | ENST00000409096 | ENST00000423110 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - |
| In-frame | ENST00000409096 | ENST00000443700 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - |
| In-frame | ENST00000409096 | ENST00000446015 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000264414 | CUL3 | chr2 | 225400245 | - | ENST00000443700 | AP1S3 | chr2 | 224642586 | - | 2347 | 717 | 339 | 1208 | 289 |
| ENST00000264414 | CUL3 | chr2 | 225400245 | - | ENST00000396654 | AP1S3 | chr2 | 224642586 | - | 1412 | 717 | 339 | 1178 | 279 |
| ENST00000264414 | CUL3 | chr2 | 225400245 | - | ENST00000396653 | AP1S3 | chr2 | 224642586 | - | 1171 | 717 | 339 | 905 | 188 |
| ENST00000264414 | CUL3 | chr2 | 225400245 | - | ENST00000446015 | AP1S3 | chr2 | 224642586 | - | 1179 | 717 | 339 | 1178 | 279 |
| ENST00000264414 | CUL3 | chr2 | 225400245 | - | ENST00000409375 | AP1S3 | chr2 | 224642586 | - | 1175 | 717 | 339 | 1127 | 262 |
| ENST00000264414 | CUL3 | chr2 | 225400245 | - | ENST00000423110 | AP1S3 | chr2 | 224642586 | - | 1029 | 717 | 339 | 1028 | 229 |
| ENST00000344951 | CUL3 | chr2 | 225400245 | - | ENST00000443700 | AP1S3 | chr2 | 224642586 | - | 2194 | 564 | 384 | 1055 | 223 |
| ENST00000344951 | CUL3 | chr2 | 225400245 | - | ENST00000396654 | AP1S3 | chr2 | 224642586 | - | 1259 | 564 | 384 | 1025 | 213 |
| ENST00000344951 | CUL3 | chr2 | 225400245 | - | ENST00000396653 | AP1S3 | chr2 | 224642586 | - | 1018 | 564 | 528 | 1 | 176 |
| ENST00000344951 | CUL3 | chr2 | 225400245 | - | ENST00000446015 | AP1S3 | chr2 | 224642586 | - | 1026 | 564 | 384 | 1025 | 213 |
| ENST00000344951 | CUL3 | chr2 | 225400245 | - | ENST00000409375 | AP1S3 | chr2 | 224642586 | - | 1022 | 564 | 384 | 974 | 196 |
| ENST00000344951 | CUL3 | chr2 | 225400245 | - | ENST00000423110 | AP1S3 | chr2 | 224642586 | - | 876 | 564 | 384 | 875 | 163 |
| ENST00000409096 | CUL3 | chr2 | 225400245 | - | ENST00000443700 | AP1S3 | chr2 | 224642586 | - | 2079 | 449 | 53 | 940 | 295 |
| ENST00000409096 | CUL3 | chr2 | 225400245 | - | ENST00000396654 | AP1S3 | chr2 | 224642586 | - | 1144 | 449 | 53 | 910 | 285 |
| ENST00000409096 | CUL3 | chr2 | 225400245 | - | ENST00000396653 | AP1S3 | chr2 | 224642586 | - | 903 | 449 | 53 | 637 | 194 |
| ENST00000409096 | CUL3 | chr2 | 225400245 | - | ENST00000446015 | AP1S3 | chr2 | 224642586 | - | 911 | 449 | 53 | 910 | 286 |
| ENST00000409096 | CUL3 | chr2 | 225400245 | - | ENST00000409375 | AP1S3 | chr2 | 224642586 | - | 907 | 449 | 53 | 859 | 268 |
| ENST00000409096 | CUL3 | chr2 | 225400245 | - | ENST00000423110 | AP1S3 | chr2 | 224642586 | - | 761 | 449 | 53 | 760 | 236 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000264414 | ENST00000443700 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - | 0.002816699 | 0.99718326 |
| ENST00000264414 | ENST00000396654 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - | 0.001964411 | 0.9980356 |
| ENST00000264414 | ENST00000396653 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - | 0.010842396 | 0.98915756 |
| ENST00000264414 | ENST00000446015 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - | 0.005646271 | 0.9943538 |
| ENST00000264414 | ENST00000409375 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - | 0.013889241 | 0.9861108 |
| ENST00000264414 | ENST00000423110 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - | 0.009725555 | 0.9902744 |
| ENST00000344951 | ENST00000443700 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - | 0.007973109 | 0.99202687 |
| ENST00000344951 | ENST00000396654 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - | 0.004738181 | 0.9952618 |
| ENST00000344951 | ENST00000396653 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - | 0.18305075 | 0.81694925 |
| ENST00000344951 | ENST00000446015 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - | 0.011051531 | 0.98894846 |
| ENST00000344951 | ENST00000409375 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - | 0.03476724 | 0.96523273 |
| ENST00000344951 | ENST00000423110 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - | 0.044889018 | 0.95511097 |
| ENST00000409096 | ENST00000443700 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - | 0.000887068 | 0.9991129 |
| ENST00000409096 | ENST00000396654 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - | 0.000491135 | 0.99950886 |
| ENST00000409096 | ENST00000396653 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - | 0.019250307 | 0.98074967 |
| ENST00000409096 | ENST00000446015 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - | 0.001084041 | 0.99891603 |
| ENST00000409096 | ENST00000409375 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - | 0.002743589 | 0.99725646 |
| ENST00000409096 | ENST00000423110 | CUL3 | chr2 | 225400245 | - | AP1S3 | chr2 | 224642586 | - | 0.003105511 | 0.9968945 |
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Fusion Genomic Features for CUL3-AP1S3 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for CUL3-AP1S3 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:225400245/chr2:224642586) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | AP1S3 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Involved in TLR3 trafficking (PubMed:24791904). {ECO:0000269|PubMed:24791904}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CUL3-AP1S3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >20663_20663_1_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000264414_AP1S3_chr2_224642586_ENST00000396653_length(transcript)=1171nt_BP=717nt CCTGCGCAGTGAGATGTTTGTCCGTCGCCGCCGCCGCCGCCATCGCGGAGGAGCGCGATAAAGGGAGCCGAGCCGGACGTGAGGGGGACC CCGCGGAGCCGCCGCGCCAGCGCAGCCCCCCAGCCGCATCGGAGTCGCCAGAGTCCGAGCCGCCGCCGCCGCCGCCGCCGCCCCCGCCGC CGCCGCGGCTGCCCAGGGGCCGGCCAGCTCCCCAGCCCTGCCCGGGGGTCGCGCCGCCGCCGCCCCCAGCGTCGCCCCTAGCCTGCCTGC CCGCCTTAAATGTGACACCGGCGTCGCGGAGCGCGACCTGAAGCCGCCGCCGGGGAGGGGACGAGCACCATGTCGAATCTGAGCAAAGGC ACGGGCAGCCGGAAGGACACCAAGATGCGGATCCGGGCCTTTCCGATGACCATGGATGAAAAATATGTAAACAGCATTTGGGACCTTCTG AAAAATGCAATTCAAGAAATCCAGCGTAAGAATAACAGTGGTCTTAGTTTTGAGGAGCTCTATAGAAATGCATATACAATGGTTTTGCAT AAACATGGAGAAAAGCTCTACACTGGACTAAGAGAAGTTGTTACCGAACATCTCATAAATAAGGTGCGAGAAGATGTACTAAATTCATTG AATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATGATTAGAGACATACTAATGTACATGATA CATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTCCCTGATAAAGAGAGGAAGAAGATCACC CGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAGGAGCTAAAACTTGTTTATAAAAGGTGT CTGTGAGCTGGATATTATCTTTAATTTTGAAAAGGCTTATTTCATCCTGGACGAGTTTATAATAGGTGGGGAAATTCAGGAAACATCCAA GAAAATTGCTGTCAAAGCCATTGAAGACTCTGATATGTTACAGGAGGTCAGTACGGTTTCCCAAACCATGGGAGAAAGATGATGATGATG ATGATGATGGTGTTAATAATTATAATATTAACCAGACTTACTGAGTACTTACTCTGTGCTGGGTACAGTTTCTAAACTATTTATATGTAT >20663_20663_1_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000264414_AP1S3_chr2_224642586_ENST00000396653_length(amino acids)=188AA_BP=0 MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVR EDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKEL -------------------------------------------------------------- >20663_20663_2_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000264414_AP1S3_chr2_224642586_ENST00000396654_length(transcript)=1412nt_BP=717nt CCTGCGCAGTGAGATGTTTGTCCGTCGCCGCCGCCGCCGCCATCGCGGAGGAGCGCGATAAAGGGAGCCGAGCCGGACGTGAGGGGGACC CCGCGGAGCCGCCGCGCCAGCGCAGCCCCCCAGCCGCATCGGAGTCGCCAGAGTCCGAGCCGCCGCCGCCGCCGCCGCCGCCCCCGCCGC CGCCGCGGCTGCCCAGGGGCCGGCCAGCTCCCCAGCCCTGCCCGGGGGTCGCGCCGCCGCCGCCCCCAGCGTCGCCCCTAGCCTGCCTGC CCGCCTTAAATGTGACACCGGCGTCGCGGAGCGCGACCTGAAGCCGCCGCCGGGGAGGGGACGAGCACCATGTCGAATCTGAGCAAAGGC ACGGGCAGCCGGAAGGACACCAAGATGCGGATCCGGGCCTTTCCGATGACCATGGATGAAAAATATGTAAACAGCATTTGGGACCTTCTG AAAAATGCAATTCAAGAAATCCAGCGTAAGAATAACAGTGGTCTTAGTTTTGAGGAGCTCTATAGAAATGCATATACAATGGTTTTGCAT AAACATGGAGAAAAGCTCTACACTGGACTAAGAGAAGTTGTTACCGAACATCTCATAAATAAGGTGCGAGAAGATGTACTAAATTCATTG AATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATGATTAGAGACATACTAATGTACATGATA CATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTCCCTGATAAAGAGAGGAAGAAGATCACC CGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAGGAGCTAAAACTTGTTTATAAAAGGTAT GCTAGTTTATATTTTTGCTGTGCAATAGAAAATCAGGACAATGAGCTCTTGACGCTAGAGATTGTGCATCGTTACGTGGAGCTGCTGGAC AAATATTTTGGAAATGTCTGTGAGCTGGATATTATCTTTAATTTTGAAAAGGCTTATTTCATCCTGGACGAGTTTATAATAGGTGGGGAA ATTCAGGAAACATCCAAGAAAATTGCTGTCAAAGCCATTGAAGACTCTGATATGTTACAGGAGACAATGGAAGAATACATGAACAAGCCT ACATTTTAACTGGAAATCTACTTGAAGACTCCAGCACTACATGTTATGAAGCTGTAAATAAGCAACGCCTCCCATCCGGTTTTTTGATGG AGCCTCAGGCACCATGCCAAAAATAATTTAAAGGGATTCTTTGTTAACTAACAAAGTTAAAGTTGTTTAACATATTTATAATTACTATGT >20663_20663_2_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000264414_AP1S3_chr2_224642586_ENST00000396654_length(amino acids)=279AA_BP=0 MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVR EDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKEL KLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIGGEIQETSKKIAVKAIEDSDMLQETM -------------------------------------------------------------- >20663_20663_3_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000264414_AP1S3_chr2_224642586_ENST00000409375_length(transcript)=1175nt_BP=717nt CCTGCGCAGTGAGATGTTTGTCCGTCGCCGCCGCCGCCGCCATCGCGGAGGAGCGCGATAAAGGGAGCCGAGCCGGACGTGAGGGGGACC CCGCGGAGCCGCCGCGCCAGCGCAGCCCCCCAGCCGCATCGGAGTCGCCAGAGTCCGAGCCGCCGCCGCCGCCGCCGCCGCCCCCGCCGC CGCCGCGGCTGCCCAGGGGCCGGCCAGCTCCCCAGCCCTGCCCGGGGGTCGCGCCGCCGCCGCCCCCAGCGTCGCCCCTAGCCTGCCTGC CCGCCTTAAATGTGACACCGGCGTCGCGGAGCGCGACCTGAAGCCGCCGCCGGGGAGGGGACGAGCACCATGTCGAATCTGAGCAAAGGC ACGGGCAGCCGGAAGGACACCAAGATGCGGATCCGGGCCTTTCCGATGACCATGGATGAAAAATATGTAAACAGCATTTGGGACCTTCTG AAAAATGCAATTCAAGAAATCCAGCGTAAGAATAACAGTGGTCTTAGTTTTGAGGAGCTCTATAGAAATGCATATACAATGGTTTTGCAT AAACATGGAGAAAAGCTCTACACTGGACTAAGAGAAGTTGTTACCGAACATCTCATAAATAAGGTGCGAGAAGATGTACTAAATTCATTG AATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATGATTAGAGACATACTAATGTACATGATA CATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTCCCTGATAAAGAGAGGAAGAAGATCACC CGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAGGAGCTAAAACTTGTTTATAAAAGGTAT GCTAGTTTATATTTTTGCTGTGCAATAGAAAATCAGGACAATGAGCTCTTGACGCTAGAGATTGTGCATCGTTACGTGGAGCTGCTGGAC AAATATTTTGGAAATGAGTTTAATTGCTGGTTTCTCCTAATGAGGCTCCTGTCTGTCTTGGATTCCTGGTCTACGCCTGCCTTGAACTCC GAGGTTCCTCAGCTTGCTACTATAACTCCTGACTTCTGCCTTTTCTGACCTCTGGTCTGTGAGCTGGATATTATCTTTAATTTTGAAAAG >20663_20663_3_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000264414_AP1S3_chr2_224642586_ENST00000409375_length(amino acids)=262AA_BP=0 MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVR EDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKEL -------------------------------------------------------------- >20663_20663_4_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000264414_AP1S3_chr2_224642586_ENST00000423110_length(transcript)=1029nt_BP=717nt CCTGCGCAGTGAGATGTTTGTCCGTCGCCGCCGCCGCCGCCATCGCGGAGGAGCGCGATAAAGGGAGCCGAGCCGGACGTGAGGGGGACC CCGCGGAGCCGCCGCGCCAGCGCAGCCCCCCAGCCGCATCGGAGTCGCCAGAGTCCGAGCCGCCGCCGCCGCCGCCGCCGCCCCCGCCGC CGCCGCGGCTGCCCAGGGGCCGGCCAGCTCCCCAGCCCTGCCCGGGGGTCGCGCCGCCGCCGCCCCCAGCGTCGCCCCTAGCCTGCCTGC CCGCCTTAAATGTGACACCGGCGTCGCGGAGCGCGACCTGAAGCCGCCGCCGGGGAGGGGACGAGCACCATGTCGAATCTGAGCAAAGGC ACGGGCAGCCGGAAGGACACCAAGATGCGGATCCGGGCCTTTCCGATGACCATGGATGAAAAATATGTAAACAGCATTTGGGACCTTCTG AAAAATGCAATTCAAGAAATCCAGCGTAAGAATAACAGTGGTCTTAGTTTTGAGGAGCTCTATAGAAATGCATATACAATGGTTTTGCAT AAACATGGAGAAAAGCTCTACACTGGACTAAGAGAAGTTGTTACCGAACATCTCATAAATAAGGTGCGAGAAGATGTACTAAATTCATTG AATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATGATTAGAGACATACTAATGTACATGATA CATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTCCCTGATAAAGAGAGGAAGAAGATCACC CGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAGGAGCTAAAACTTGTTTATAAAAGGTAT GCTAGTTTATATTTTTGCTGTGCAATAGAAAATCAGGACAATGAGCTCTTGACGCTAGAGATTGTGCATCGTTACGTGGAGCTGCTGGAC >20663_20663_4_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000264414_AP1S3_chr2_224642586_ENST00000423110_length(amino acids)=229AA_BP=0 MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVR EDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKEL -------------------------------------------------------------- >20663_20663_5_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000264414_AP1S3_chr2_224642586_ENST00000443700_length(transcript)=2347nt_BP=717nt CCTGCGCAGTGAGATGTTTGTCCGTCGCCGCCGCCGCCGCCATCGCGGAGGAGCGCGATAAAGGGAGCCGAGCCGGACGTGAGGGGGACC CCGCGGAGCCGCCGCGCCAGCGCAGCCCCCCAGCCGCATCGGAGTCGCCAGAGTCCGAGCCGCCGCCGCCGCCGCCGCCGCCCCCGCCGC CGCCGCGGCTGCCCAGGGGCCGGCCAGCTCCCCAGCCCTGCCCGGGGGTCGCGCCGCCGCCGCCCCCAGCGTCGCCCCTAGCCTGCCTGC CCGCCTTAAATGTGACACCGGCGTCGCGGAGCGCGACCTGAAGCCGCCGCCGGGGAGGGGACGAGCACCATGTCGAATCTGAGCAAAGGC ACGGGCAGCCGGAAGGACACCAAGATGCGGATCCGGGCCTTTCCGATGACCATGGATGAAAAATATGTAAACAGCATTTGGGACCTTCTG AAAAATGCAATTCAAGAAATCCAGCGTAAGAATAACAGTGGTCTTAGTTTTGAGGAGCTCTATAGAAATGCATATACAATGGTTTTGCAT AAACATGGAGAAAAGCTCTACACTGGACTAAGAGAAGTTGTTACCGAACATCTCATAAATAAGGTGCGAGAAGATGTACTAAATTCATTG AATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATGATTAGAGACATACTAATGTACATGATA CATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTCCCTGATAAAGAGAGGAAGAAGATCACC CGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAGGAGCTAAAACTTGTTTATAAAAGGTAT GCTAGTTTATATTTTTGCTGTGCAATAGAAAATCAGGACAATGAGCTCTTGACGCTAGAGATTGTGCATCGTTACGTGGAGCTGCTGGAC AAATATTTTGGAAATGTCTGTGAGCTGGATATTATCTTTAATTTTGAAAAGGCTTATTTCATCCTGGACGAGTTTATAATAGGTGGGGAA ATTCAGGAAACATCCAAGAAAATTGCTGTCAAAGCCATTGAAGACTCTGATATGTTACAGGAGAATCGTTTGAGCCCCAGAGGCAGAGAT TGCAGTGAGCCGAGATCATGCCATTGCACTCTAGCCTAGGCAACAAGAGCAAAACTCCATCTAAAAAAAAAAAAAAAGAAAAGAAAAAGG AGAATTATGAAGAACTTGGTTCCACAAGTAAGATAGTCCTCATACTGCATCAGTAGTGACTTAAACTTTTTTAAAACTTTTATTTTTTGT GGGGGGATCTGTTGAATTTGGGAAGCCTCCAGTTTTAATAAAATTTTTTTATTATGGTGGAAACATGTCTGTAAAACTTAGGACTATAGA AATGCAAAGAATAAAGAACTGAGGGAGTTACACACATTTGTAGTCAGAAATTAAGTTCAAAAAATAATTTAGGTCATTTGCATTTTTTAG TATGCAAAATAAATGGAAAAATTAAAGTGCAATAAAAATATAATTTGGGAAATGAATGCAGTAAAATTGAAAACATTGAAATATTATAAT TTAATAAAATAAACTTCAAAAAATGTATGAAAATATAAGTATCTTTACTTATATAGGATTAAATATATTTCTGATAATCTGTCCTCTATA ATGAATTGGTTTAATTATGTTTTTCTGTTTTTAGAAATGGGCATCTTTTTATTTCTGGAAACAACTTTTTAATGAGATTTTATCAAACAT TAGACTATGACTAATTATAATATTCAAAGCCAATACCAAAACGATGGATAAATAAATGAATAAAACAAGGCACATTAATAGAAAAAAATG AATGAAATCAATTACGGGTTCTACTTGAAACACCTAATCTCATTATAATAGCAATAATAAAACAATTTGTACATACTTTATTAGTCGAAC ATTTATTAAAAATATAAGAGCATAGAGCAAATTAATTTGGAAGAAAATTTAAATCTTTTACATACAAATACCCTCAAGAATAATAAATCA TGGAGTATTAATAAAATTAAACCAGCTGATAATTTTAGAAAGTGCTTCATGCACAGAGACTTTTATTCAAGTCCTCTTTGCTTTCTGCTA GTGCTTTTTTTTTTTTCTTGAAATGGGATGGGATCTCACTCTGTCACCCAGGCTGGAGTGCAGTAGCACGATAGCAGCGCACTGCAACCT GGACCTCCTGGGCTCAAGCAATCCTCTCACCGCAGCCTCCTGAGTAGCTGGGGCTACAGGTGTGTGCCACCATACTTGGCTAATTAAAAA >20663_20663_5_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000264414_AP1S3_chr2_224642586_ENST00000443700_length(amino acids)=289AA_BP=0 MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVR EDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKEL KLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIGGEIQETSKKIAVKAIEDSDMLQENR -------------------------------------------------------------- >20663_20663_6_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000264414_AP1S3_chr2_224642586_ENST00000446015_length(transcript)=1179nt_BP=717nt CCTGCGCAGTGAGATGTTTGTCCGTCGCCGCCGCCGCCGCCATCGCGGAGGAGCGCGATAAAGGGAGCCGAGCCGGACGTGAGGGGGACC CCGCGGAGCCGCCGCGCCAGCGCAGCCCCCCAGCCGCATCGGAGTCGCCAGAGTCCGAGCCGCCGCCGCCGCCGCCGCCGCCCCCGCCGC CGCCGCGGCTGCCCAGGGGCCGGCCAGCTCCCCAGCCCTGCCCGGGGGTCGCGCCGCCGCCGCCCCCAGCGTCGCCCCTAGCCTGCCTGC CCGCCTTAAATGTGACACCGGCGTCGCGGAGCGCGACCTGAAGCCGCCGCCGGGGAGGGGACGAGCACCATGTCGAATCTGAGCAAAGGC ACGGGCAGCCGGAAGGACACCAAGATGCGGATCCGGGCCTTTCCGATGACCATGGATGAAAAATATGTAAACAGCATTTGGGACCTTCTG AAAAATGCAATTCAAGAAATCCAGCGTAAGAATAACAGTGGTCTTAGTTTTGAGGAGCTCTATAGAAATGCATATACAATGGTTTTGCAT AAACATGGAGAAAAGCTCTACACTGGACTAAGAGAAGTTGTTACCGAACATCTCATAAATAAGGTGCGAGAAGATGTACTAAATTCATTG AATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATGATTAGAGACATACTAATGTACATGATA CATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTCCCTGATAAAGAGAGGAAGAAGATCACC CGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAGGAGCTAAAACTTGTTTATAAAAGGTAT GCTAGTTTATATTTTTGCTGTGCAATAGAAAATCAGGACAATGAGCTCTTGACGCTAGAGATTGTGCATCGTTACGTGGAGCTGCTGGAC AAATATTTTGGAAATGTCTGTGAGCTGGATATTATCTTTAATTTTGAAAAGGCTTATTTCATCCTGGACGAGTTTATAATAGGTGGGGAA ATTCAGGAAACATCCAAGAAAATTGCTGTCAAAGCCATTGAAGACTCTGATATGTTACAGGAGGTCAGTACGGTTTCCCAAACCATGGGA >20663_20663_6_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000264414_AP1S3_chr2_224642586_ENST00000446015_length(amino acids)=279AA_BP=0 MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVR EDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKEL KLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIGGEIQETSKKIAVKAIEDSDMLQEVS -------------------------------------------------------------- >20663_20663_7_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000344951_AP1S3_chr2_224642586_ENST00000396653_length(transcript)=1018nt_BP=564nt GCTCAGGCGGAGGAGGAGAAGGAGGAGGAGGAGGACGACGTTCGGCCTGCGCAGTGAGATGTTTGTCCGTCGCCGCCGCCGCCGCCATCG CGGAGGAGCGCGATAAAGGGAGCCGAGCCGGACGTGAGGGGGACCCCGCGGAGCCGCCGCGCCAGCGCAGCCCCCCAGCCGCATCGGAGT CGCCAGAGTCCGAGCCGCCGCCGCCGCCGCCGCCGCCCCCGCCGCCGCCGCGGCTGCCCAGGGGCCGGCCAGCTCCCCAGCCCTGCCCGG GGGTCGCGCCGCCGCCGCCCCCAGCGTCGCCCCTAGCCTGCCTGCCCGCCTTAAATGTGACACCGGCGTCGCGGAGCGCGACCTGAAGCC GCCGCCGGGGAGGGGACGAGCACCATGTCGAATCTGAGCAAAGGCACGGGCAGCCGGAAGGACACCAAGATGCGGATCCGGGCCTTTCCG GTGCGAGAAGATGTACTAAATTCATTGAATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATG ATTAGAGACATACTAATGTACATGATACATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTC CCTGATAAAGAGAGGAAGAAGATCACCCGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAG GAGCTAAAACTTGTTTATAAAAGGTGTCTGTGAGCTGGATATTATCTTTAATTTTGAAAAGGCTTATTTCATCCTGGACGAGTTTATAAT AGGTGGGGAAATTCAGGAAACATCCAAGAAAATTGCTGTCAAAGCCATTGAAGACTCTGATATGTTACAGGAGGTCAGTACGGTTTCCCA AACCATGGGAGAAAGATGATGATGATGATGATGATGGTGTTAATAATTATAATATTAACCAGACTTACTGAGTACTTACTCTGTGCTGGG >20663_20663_7_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000344951_AP1S3_chr2_224642586_ENST00000396653_length(amino acids)=176AA_BP= MFDDHSKLDLAFEESCYSMNLVHLLAPERPGSASWCPSGCPCLCSDSTWCSSPPRRRLQVALRDAGVTFKAGRQARGDAGGGGGATPGQG -------------------------------------------------------------- >20663_20663_8_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000344951_AP1S3_chr2_224642586_ENST00000396654_length(transcript)=1259nt_BP=564nt GCTCAGGCGGAGGAGGAGAAGGAGGAGGAGGAGGACGACGTTCGGCCTGCGCAGTGAGATGTTTGTCCGTCGCCGCCGCCGCCGCCATCG CGGAGGAGCGCGATAAAGGGAGCCGAGCCGGACGTGAGGGGGACCCCGCGGAGCCGCCGCGCCAGCGCAGCCCCCCAGCCGCATCGGAGT CGCCAGAGTCCGAGCCGCCGCCGCCGCCGCCGCCGCCCCCGCCGCCGCCGCGGCTGCCCAGGGGCCGGCCAGCTCCCCAGCCCTGCCCGG GGGTCGCGCCGCCGCCGCCCCCAGCGTCGCCCCTAGCCTGCCTGCCCGCCTTAAATGTGACACCGGCGTCGCGGAGCGCGACCTGAAGCC GCCGCCGGGGAGGGGACGAGCACCATGTCGAATCTGAGCAAAGGCACGGGCAGCCGGAAGGACACCAAGATGCGGATCCGGGCCTTTCCG GTGCGAGAAGATGTACTAAATTCATTGAATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATG ATTAGAGACATACTAATGTACATGATACATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTC CCTGATAAAGAGAGGAAGAAGATCACCCGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAG GAGCTAAAACTTGTTTATAAAAGGTATGCTAGTTTATATTTTTGCTGTGCAATAGAAAATCAGGACAATGAGCTCTTGACGCTAGAGATT GTGCATCGTTACGTGGAGCTGCTGGACAAATATTTTGGAAATGTCTGTGAGCTGGATATTATCTTTAATTTTGAAAAGGCTTATTTCATC CTGGACGAGTTTATAATAGGTGGGGAAATTCAGGAAACATCCAAGAAAATTGCTGTCAAAGCCATTGAAGACTCTGATATGTTACAGGAG ACAATGGAAGAATACATGAACAAGCCTACATTTTAACTGGAAATCTACTTGAAGACTCCAGCACTACATGTTATGAAGCTGTAAATAAGC AACGCCTCCCATCCGGTTTTTTGATGGAGCCTCAGGCACCATGCCAAAAATAATTTAAAGGGATTCTTTGTTAACTAACAAAGTTAAAGT >20663_20663_8_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000344951_AP1S3_chr2_224642586_ENST00000396654_length(amino acids)=213AA_BP=0 MSNLSKGTGSRKDTKMRIRAFPVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKI TREIVQIILSRGHRTSSFVDWKELKLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIGG -------------------------------------------------------------- >20663_20663_9_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000344951_AP1S3_chr2_224642586_ENST00000409375_length(transcript)=1022nt_BP=564nt GCTCAGGCGGAGGAGGAGAAGGAGGAGGAGGAGGACGACGTTCGGCCTGCGCAGTGAGATGTTTGTCCGTCGCCGCCGCCGCCGCCATCG CGGAGGAGCGCGATAAAGGGAGCCGAGCCGGACGTGAGGGGGACCCCGCGGAGCCGCCGCGCCAGCGCAGCCCCCCAGCCGCATCGGAGT CGCCAGAGTCCGAGCCGCCGCCGCCGCCGCCGCCGCCCCCGCCGCCGCCGCGGCTGCCCAGGGGCCGGCCAGCTCCCCAGCCCTGCCCGG GGGTCGCGCCGCCGCCGCCCCCAGCGTCGCCCCTAGCCTGCCTGCCCGCCTTAAATGTGACACCGGCGTCGCGGAGCGCGACCTGAAGCC GCCGCCGGGGAGGGGACGAGCACCATGTCGAATCTGAGCAAAGGCACGGGCAGCCGGAAGGACACCAAGATGCGGATCCGGGCCTTTCCG GTGCGAGAAGATGTACTAAATTCATTGAATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATG ATTAGAGACATACTAATGTACATGATACATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTC CCTGATAAAGAGAGGAAGAAGATCACCCGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAG GAGCTAAAACTTGTTTATAAAAGGTATGCTAGTTTATATTTTTGCTGTGCAATAGAAAATCAGGACAATGAGCTCTTGACGCTAGAGATT GTGCATCGTTACGTGGAGCTGCTGGACAAATATTTTGGAAATGAGTTTAATTGCTGGTTTCTCCTAATGAGGCTCCTGTCTGTCTTGGAT TCCTGGTCTACGCCTGCCTTGAACTCCGAGGTTCCTCAGCTTGCTACTATAACTCCTGACTTCTGCCTTTTCTGACCTCTGGTCTGTGAG >20663_20663_9_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000344951_AP1S3_chr2_224642586_ENST00000409375_length(amino acids)=196AA_BP=0 MSNLSKGTGSRKDTKMRIRAFPVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKI TREIVQIILSRGHRTSSFVDWKELKLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNEFNCWFLLMRLLSVLDSWSTPALN -------------------------------------------------------------- >20663_20663_10_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000344951_AP1S3_chr2_224642586_ENST00000423110_length(transcript)=876nt_BP=564nt GCTCAGGCGGAGGAGGAGAAGGAGGAGGAGGAGGACGACGTTCGGCCTGCGCAGTGAGATGTTTGTCCGTCGCCGCCGCCGCCGCCATCG CGGAGGAGCGCGATAAAGGGAGCCGAGCCGGACGTGAGGGGGACCCCGCGGAGCCGCCGCGCCAGCGCAGCCCCCCAGCCGCATCGGAGT CGCCAGAGTCCGAGCCGCCGCCGCCGCCGCCGCCGCCCCCGCCGCCGCCGCGGCTGCCCAGGGGCCGGCCAGCTCCCCAGCCCTGCCCGG GGGTCGCGCCGCCGCCGCCCCCAGCGTCGCCCCTAGCCTGCCTGCCCGCCTTAAATGTGACACCGGCGTCGCGGAGCGCGACCTGAAGCC GCCGCCGGGGAGGGGACGAGCACCATGTCGAATCTGAGCAAAGGCACGGGCAGCCGGAAGGACACCAAGATGCGGATCCGGGCCTTTCCG GTGCGAGAAGATGTACTAAATTCATTGAATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATG ATTAGAGACATACTAATGTACATGATACATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTC CCTGATAAAGAGAGGAAGAAGATCACCCGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAG GAGCTAAAACTTGTTTATAAAAGGTATGCTAGTTTATATTTTTGCTGTGCAATAGAAAATCAGGACAATGAGCTCTTGACGCTAGAGATT >20663_20663_10_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000344951_AP1S3_chr2_224642586_ENST00000423110_length(amino acids)=163AA_BP=0 MSNLSKGTGSRKDTKMRIRAFPVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKI -------------------------------------------------------------- >20663_20663_11_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000344951_AP1S3_chr2_224642586_ENST00000443700_length(transcript)=2194nt_BP=564nt GCTCAGGCGGAGGAGGAGAAGGAGGAGGAGGAGGACGACGTTCGGCCTGCGCAGTGAGATGTTTGTCCGTCGCCGCCGCCGCCGCCATCG CGGAGGAGCGCGATAAAGGGAGCCGAGCCGGACGTGAGGGGGACCCCGCGGAGCCGCCGCGCCAGCGCAGCCCCCCAGCCGCATCGGAGT CGCCAGAGTCCGAGCCGCCGCCGCCGCCGCCGCCGCCCCCGCCGCCGCCGCGGCTGCCCAGGGGCCGGCCAGCTCCCCAGCCCTGCCCGG GGGTCGCGCCGCCGCCGCCCCCAGCGTCGCCCCTAGCCTGCCTGCCCGCCTTAAATGTGACACCGGCGTCGCGGAGCGCGACCTGAAGCC GCCGCCGGGGAGGGGACGAGCACCATGTCGAATCTGAGCAAAGGCACGGGCAGCCGGAAGGACACCAAGATGCGGATCCGGGCCTTTCCG GTGCGAGAAGATGTACTAAATTCATTGAATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATG ATTAGAGACATACTAATGTACATGATACATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTC CCTGATAAAGAGAGGAAGAAGATCACCCGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAG GAGCTAAAACTTGTTTATAAAAGGTATGCTAGTTTATATTTTTGCTGTGCAATAGAAAATCAGGACAATGAGCTCTTGACGCTAGAGATT GTGCATCGTTACGTGGAGCTGCTGGACAAATATTTTGGAAATGTCTGTGAGCTGGATATTATCTTTAATTTTGAAAAGGCTTATTTCATC CTGGACGAGTTTATAATAGGTGGGGAAATTCAGGAAACATCCAAGAAAATTGCTGTCAAAGCCATTGAAGACTCTGATATGTTACAGGAG AATCGTTTGAGCCCCAGAGGCAGAGATTGCAGTGAGCCGAGATCATGCCATTGCACTCTAGCCTAGGCAACAAGAGCAAAACTCCATCTA AAAAAAAAAAAAAAGAAAAGAAAAAGGAGAATTATGAAGAACTTGGTTCCACAAGTAAGATAGTCCTCATACTGCATCAGTAGTGACTTA AACTTTTTTAAAACTTTTATTTTTTGTGGGGGGATCTGTTGAATTTGGGAAGCCTCCAGTTTTAATAAAATTTTTTTATTATGGTGGAAA CATGTCTGTAAAACTTAGGACTATAGAAATGCAAAGAATAAAGAACTGAGGGAGTTACACACATTTGTAGTCAGAAATTAAGTTCAAAAA ATAATTTAGGTCATTTGCATTTTTTAGTATGCAAAATAAATGGAAAAATTAAAGTGCAATAAAAATATAATTTGGGAAATGAATGCAGTA AAATTGAAAACATTGAAATATTATAATTTAATAAAATAAACTTCAAAAAATGTATGAAAATATAAGTATCTTTACTTATATAGGATTAAA TATATTTCTGATAATCTGTCCTCTATAATGAATTGGTTTAATTATGTTTTTCTGTTTTTAGAAATGGGCATCTTTTTATTTCTGGAAACA ACTTTTTAATGAGATTTTATCAAACATTAGACTATGACTAATTATAATATTCAAAGCCAATACCAAAACGATGGATAAATAAATGAATAA AACAAGGCACATTAATAGAAAAAAATGAATGAAATCAATTACGGGTTCTACTTGAAACACCTAATCTCATTATAATAGCAATAATAAAAC AATTTGTACATACTTTATTAGTCGAACATTTATTAAAAATATAAGAGCATAGAGCAAATTAATTTGGAAGAAAATTTAAATCTTTTACAT ACAAATACCCTCAAGAATAATAAATCATGGAGTATTAATAAAATTAAACCAGCTGATAATTTTAGAAAGTGCTTCATGCACAGAGACTTT TATTCAAGTCCTCTTTGCTTTCTGCTAGTGCTTTTTTTTTTTTCTTGAAATGGGATGGGATCTCACTCTGTCACCCAGGCTGGAGTGCAG TAGCACGATAGCAGCGCACTGCAACCTGGACCTCCTGGGCTCAAGCAATCCTCTCACCGCAGCCTCCTGAGTAGCTGGGGCTACAGGTGT >20663_20663_11_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000344951_AP1S3_chr2_224642586_ENST00000443700_length(amino acids)=223AA_BP=0 MSNLSKGTGSRKDTKMRIRAFPVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKI TREIVQIILSRGHRTSSFVDWKELKLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIGG -------------------------------------------------------------- >20663_20663_12_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000344951_AP1S3_chr2_224642586_ENST00000446015_length(transcript)=1026nt_BP=564nt GCTCAGGCGGAGGAGGAGAAGGAGGAGGAGGAGGACGACGTTCGGCCTGCGCAGTGAGATGTTTGTCCGTCGCCGCCGCCGCCGCCATCG CGGAGGAGCGCGATAAAGGGAGCCGAGCCGGACGTGAGGGGGACCCCGCGGAGCCGCCGCGCCAGCGCAGCCCCCCAGCCGCATCGGAGT CGCCAGAGTCCGAGCCGCCGCCGCCGCCGCCGCCGCCCCCGCCGCCGCCGCGGCTGCCCAGGGGCCGGCCAGCTCCCCAGCCCTGCCCGG GGGTCGCGCCGCCGCCGCCCCCAGCGTCGCCCCTAGCCTGCCTGCCCGCCTTAAATGTGACACCGGCGTCGCGGAGCGCGACCTGAAGCC GCCGCCGGGGAGGGGACGAGCACCATGTCGAATCTGAGCAAAGGCACGGGCAGCCGGAAGGACACCAAGATGCGGATCCGGGCCTTTCCG GTGCGAGAAGATGTACTAAATTCATTGAATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATG ATTAGAGACATACTAATGTACATGATACATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTC CCTGATAAAGAGAGGAAGAAGATCACCCGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAG GAGCTAAAACTTGTTTATAAAAGGTATGCTAGTTTATATTTTTGCTGTGCAATAGAAAATCAGGACAATGAGCTCTTGACGCTAGAGATT GTGCATCGTTACGTGGAGCTGCTGGACAAATATTTTGGAAATGTCTGTGAGCTGGATATTATCTTTAATTTTGAAAAGGCTTATTTCATC CTGGACGAGTTTATAATAGGTGGGGAAATTCAGGAAACATCCAAGAAAATTGCTGTCAAAGCCATTGAAGACTCTGATATGTTACAGGAG >20663_20663_12_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000344951_AP1S3_chr2_224642586_ENST00000446015_length(amino acids)=213AA_BP=0 MSNLSKGTGSRKDTKMRIRAFPVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKI TREIVQIILSRGHRTSSFVDWKELKLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIGG -------------------------------------------------------------- >20663_20663_13_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000409096_AP1S3_chr2_224642586_ENST00000396653_length(transcript)=903nt_BP=449nt GTAGAAAATTATTCACAGAGGACTAAAGACTTCTTGTCCTTTGTATGTAGTAGATGTTAAGAATTCACTTCTTTTCATTTAGTTTTAATT TGTCTCATGATGTAGTTCTCTCAGTAATCACAGAACCTTCAAGATGTATGACCATGGATGAAAAATATGTAAACAGCATTTGGGACCTTC TGAAAAATGCAATTCAAGAAATCCAGCGTAAGAATAACAGTGGTCTTAGTTTTGAGGAGCTCTATAGAAATGCATATACAATGGTTTTGC ATAAACATGGAGAAAAGCTCTACACTGGACTAAGAGAAGTTGTTACCGAACATCTCATAAATAAGGTGCGAGAAGATGTACTAAATTCAT TGAATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATGATTAGAGACATACTAATGTACATGA TACATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTCCCTGATAAAGAGAGGAAGAAGATCA CCCGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAGGAGCTAAAACTTGTTTATAAAAGGT GTCTGTGAGCTGGATATTATCTTTAATTTTGAAAAGGCTTATTTCATCCTGGACGAGTTTATAATAGGTGGGGAAATTCAGGAAACATCC AAGAAAATTGCTGTCAAAGCCATTGAAGACTCTGATATGTTACAGGAGGTCAGTACGGTTTCCCAAACCATGGGAGAAAGATGATGATGA TGATGATGATGGTGTTAATAATTATAATATTAACCAGACTTACTGAGTACTTACTCTGTGCTGGGTACAGTTTCTAAACTATTTATATGT >20663_20663_13_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000409096_AP1S3_chr2_224642586_ENST00000396653_length(amino acids)=194AA_BP=0 MLRIHFFSFSFNLSHDVVLSVITEPSRCMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEH LINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSF -------------------------------------------------------------- >20663_20663_14_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000409096_AP1S3_chr2_224642586_ENST00000396654_length(transcript)=1144nt_BP=449nt GTAGAAAATTATTCACAGAGGACTAAAGACTTCTTGTCCTTTGTATGTAGTAGATGTTAAGAATTCACTTCTTTTCATTTAGTTTTAATT TGTCTCATGATGTAGTTCTCTCAGTAATCACAGAACCTTCAAGATGTATGACCATGGATGAAAAATATGTAAACAGCATTTGGGACCTTC TGAAAAATGCAATTCAAGAAATCCAGCGTAAGAATAACAGTGGTCTTAGTTTTGAGGAGCTCTATAGAAATGCATATACAATGGTTTTGC ATAAACATGGAGAAAAGCTCTACACTGGACTAAGAGAAGTTGTTACCGAACATCTCATAAATAAGGTGCGAGAAGATGTACTAAATTCAT TGAATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATGATTAGAGACATACTAATGTACATGA TACATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTCCCTGATAAAGAGAGGAAGAAGATCA CCCGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAGGAGCTAAAACTTGTTTATAAAAGGT ATGCTAGTTTATATTTTTGCTGTGCAATAGAAAATCAGGACAATGAGCTCTTGACGCTAGAGATTGTGCATCGTTACGTGGAGCTGCTGG ACAAATATTTTGGAAATGTCTGTGAGCTGGATATTATCTTTAATTTTGAAAAGGCTTATTTCATCCTGGACGAGTTTATAATAGGTGGGG AAATTCAGGAAACATCCAAGAAAATTGCTGTCAAAGCCATTGAAGACTCTGATATGTTACAGGAGACAATGGAAGAATACATGAACAAGC CTACATTTTAACTGGAAATCTACTTGAAGACTCCAGCACTACATGTTATGAAGCTGTAAATAAGCAACGCCTCCCATCCGGTTTTTTGAT GGAGCCTCAGGCACCATGCCAAAAATAATTTAAAGGGATTCTTTGTTAACTAACAAAGTTAAAGTTGTTTAACATATTTATAATTACTAT >20663_20663_14_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000409096_AP1S3_chr2_224642586_ENST00000396654_length(amino acids)=285AA_BP=0 MLRIHFFSFSFNLSHDVVLSVITEPSRCMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEH LINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSF VDWKELKLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIGGEIQETSKKIAVKAIEDSD -------------------------------------------------------------- >20663_20663_15_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000409096_AP1S3_chr2_224642586_ENST00000409375_length(transcript)=907nt_BP=449nt GTAGAAAATTATTCACAGAGGACTAAAGACTTCTTGTCCTTTGTATGTAGTAGATGTTAAGAATTCACTTCTTTTCATTTAGTTTTAATT TGTCTCATGATGTAGTTCTCTCAGTAATCACAGAACCTTCAAGATGTATGACCATGGATGAAAAATATGTAAACAGCATTTGGGACCTTC TGAAAAATGCAATTCAAGAAATCCAGCGTAAGAATAACAGTGGTCTTAGTTTTGAGGAGCTCTATAGAAATGCATATACAATGGTTTTGC ATAAACATGGAGAAAAGCTCTACACTGGACTAAGAGAAGTTGTTACCGAACATCTCATAAATAAGGTGCGAGAAGATGTACTAAATTCAT TGAATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATGATTAGAGACATACTAATGTACATGA TACATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTCCCTGATAAAGAGAGGAAGAAGATCA CCCGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAGGAGCTAAAACTTGTTTATAAAAGGT ATGCTAGTTTATATTTTTGCTGTGCAATAGAAAATCAGGACAATGAGCTCTTGACGCTAGAGATTGTGCATCGTTACGTGGAGCTGCTGG ACAAATATTTTGGAAATGAGTTTAATTGCTGGTTTCTCCTAATGAGGCTCCTGTCTGTCTTGGATTCCTGGTCTACGCCTGCCTTGAACT CCGAGGTTCCTCAGCTTGCTACTATAACTCCTGACTTCTGCCTTTTCTGACCTCTGGTCTGTGAGCTGGATATTATCTTTAATTTTGAAA >20663_20663_15_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000409096_AP1S3_chr2_224642586_ENST00000409375_length(amino acids)=268AA_BP=0 MLRIHFFSFSFNLSHDVVLSVITEPSRCMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEH LINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSF -------------------------------------------------------------- >20663_20663_16_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000409096_AP1S3_chr2_224642586_ENST00000423110_length(transcript)=761nt_BP=449nt GTAGAAAATTATTCACAGAGGACTAAAGACTTCTTGTCCTTTGTATGTAGTAGATGTTAAGAATTCACTTCTTTTCATTTAGTTTTAATT TGTCTCATGATGTAGTTCTCTCAGTAATCACAGAACCTTCAAGATGTATGACCATGGATGAAAAATATGTAAACAGCATTTGGGACCTTC TGAAAAATGCAATTCAAGAAATCCAGCGTAAGAATAACAGTGGTCTTAGTTTTGAGGAGCTCTATAGAAATGCATATACAATGGTTTTGC ATAAACATGGAGAAAAGCTCTACACTGGACTAAGAGAAGTTGTTACCGAACATCTCATAAATAAGGTGCGAGAAGATGTACTAAATTCAT TGAATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATGATTAGAGACATACTAATGTACATGA TACATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTCCCTGATAAAGAGAGGAAGAAGATCA CCCGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAGGAGCTAAAACTTGTTTATAAAAGGT ATGCTAGTTTATATTTTTGCTGTGCAATAGAAAATCAGGACAATGAGCTCTTGACGCTAGAGATTGTGCATCGTTACGTGGAGCTGCTGG >20663_20663_16_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000409096_AP1S3_chr2_224642586_ENST00000423110_length(amino acids)=236AA_BP=0 MLRIHFFSFSFNLSHDVVLSVITEPSRCMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEH LINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSF -------------------------------------------------------------- >20663_20663_17_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000409096_AP1S3_chr2_224642586_ENST00000443700_length(transcript)=2079nt_BP=449nt GTAGAAAATTATTCACAGAGGACTAAAGACTTCTTGTCCTTTGTATGTAGTAGATGTTAAGAATTCACTTCTTTTCATTTAGTTTTAATT TGTCTCATGATGTAGTTCTCTCAGTAATCACAGAACCTTCAAGATGTATGACCATGGATGAAAAATATGTAAACAGCATTTGGGACCTTC TGAAAAATGCAATTCAAGAAATCCAGCGTAAGAATAACAGTGGTCTTAGTTTTGAGGAGCTCTATAGAAATGCATATACAATGGTTTTGC ATAAACATGGAGAAAAGCTCTACACTGGACTAAGAGAAGTTGTTACCGAACATCTCATAAATAAGGTGCGAGAAGATGTACTAAATTCAT TGAATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATGATTAGAGACATACTAATGTACATGA TACATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTCCCTGATAAAGAGAGGAAGAAGATCA CCCGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAGGAGCTAAAACTTGTTTATAAAAGGT ATGCTAGTTTATATTTTTGCTGTGCAATAGAAAATCAGGACAATGAGCTCTTGACGCTAGAGATTGTGCATCGTTACGTGGAGCTGCTGG ACAAATATTTTGGAAATGTCTGTGAGCTGGATATTATCTTTAATTTTGAAAAGGCTTATTTCATCCTGGACGAGTTTATAATAGGTGGGG AAATTCAGGAAACATCCAAGAAAATTGCTGTCAAAGCCATTGAAGACTCTGATATGTTACAGGAGAATCGTTTGAGCCCCAGAGGCAGAG ATTGCAGTGAGCCGAGATCATGCCATTGCACTCTAGCCTAGGCAACAAGAGCAAAACTCCATCTAAAAAAAAAAAAAAAGAAAAGAAAAA GGAGAATTATGAAGAACTTGGTTCCACAAGTAAGATAGTCCTCATACTGCATCAGTAGTGACTTAAACTTTTTTAAAACTTTTATTTTTT GTGGGGGGATCTGTTGAATTTGGGAAGCCTCCAGTTTTAATAAAATTTTTTTATTATGGTGGAAACATGTCTGTAAAACTTAGGACTATA GAAATGCAAAGAATAAAGAACTGAGGGAGTTACACACATTTGTAGTCAGAAATTAAGTTCAAAAAATAATTTAGGTCATTTGCATTTTTT AGTATGCAAAATAAATGGAAAAATTAAAGTGCAATAAAAATATAATTTGGGAAATGAATGCAGTAAAATTGAAAACATTGAAATATTATA ATTTAATAAAATAAACTTCAAAAAATGTATGAAAATATAAGTATCTTTACTTATATAGGATTAAATATATTTCTGATAATCTGTCCTCTA TAATGAATTGGTTTAATTATGTTTTTCTGTTTTTAGAAATGGGCATCTTTTTATTTCTGGAAACAACTTTTTAATGAGATTTTATCAAAC ATTAGACTATGACTAATTATAATATTCAAAGCCAATACCAAAACGATGGATAAATAAATGAATAAAACAAGGCACATTAATAGAAAAAAA TGAATGAAATCAATTACGGGTTCTACTTGAAACACCTAATCTCATTATAATAGCAATAATAAAACAATTTGTACATACTTTATTAGTCGA ACATTTATTAAAAATATAAGAGCATAGAGCAAATTAATTTGGAAGAAAATTTAAATCTTTTACATACAAATACCCTCAAGAATAATAAAT CATGGAGTATTAATAAAATTAAACCAGCTGATAATTTTAGAAAGTGCTTCATGCACAGAGACTTTTATTCAAGTCCTCTTTGCTTTCTGC TAGTGCTTTTTTTTTTTTCTTGAAATGGGATGGGATCTCACTCTGTCACCCAGGCTGGAGTGCAGTAGCACGATAGCAGCGCACTGCAAC CTGGACCTCCTGGGCTCAAGCAATCCTCTCACCGCAGCCTCCTGAGTAGCTGGGGCTACAGGTGTGTGCCACCATACTTGGCTAATTAAA >20663_20663_17_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000409096_AP1S3_chr2_224642586_ENST00000443700_length(amino acids)=295AA_BP=0 MLRIHFFSFSFNLSHDVVLSVITEPSRCMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEH LINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSF VDWKELKLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIGGEIQETSKKIAVKAIEDSD -------------------------------------------------------------- >20663_20663_18_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000409096_AP1S3_chr2_224642586_ENST00000446015_length(transcript)=911nt_BP=449nt GTAGAAAATTATTCACAGAGGACTAAAGACTTCTTGTCCTTTGTATGTAGTAGATGTTAAGAATTCACTTCTTTTCATTTAGTTTTAATT TGTCTCATGATGTAGTTCTCTCAGTAATCACAGAACCTTCAAGATGTATGACCATGGATGAAAAATATGTAAACAGCATTTGGGACCTTC TGAAAAATGCAATTCAAGAAATCCAGCGTAAGAATAACAGTGGTCTTAGTTTTGAGGAGCTCTATAGAAATGCATATACAATGGTTTTGC ATAAACATGGAGAAAAGCTCTACACTGGACTAAGAGAAGTTGTTACCGAACATCTCATAAATAAGGTGCGAGAAGATGTACTAAATTCAT TGAATAACAACTTTCTTCAAACGCTAAATCAAGCTTGGAATGATCATCAAACAGCTATGGTGATGATTAGAGACATACTAATGTACATGA TACATTTCATATTGCTCTTCAGTCGACAAGGGAAATTACGGCTACAGAAATGGTACATCACTCTCCCTGATAAAGAGAGGAAGAAGATCA CCCGGGAAATTGTTCAGATTATTCTCTCCCGTGGTCACAGGACAAGCAGTTTTGTTGACTGGAAGGAGCTAAAACTTGTTTATAAAAGGT ATGCTAGTTTATATTTTTGCTGTGCAATAGAAAATCAGGACAATGAGCTCTTGACGCTAGAGATTGTGCATCGTTACGTGGAGCTGCTGG ACAAATATTTTGGAAATGTCTGTGAGCTGGATATTATCTTTAATTTTGAAAAGGCTTATTTCATCCTGGACGAGTTTATAATAGGTGGGG AAATTCAGGAAACATCCAAGAAAATTGCTGTCAAAGCCATTGAAGACTCTGATATGTTACAGGAGGTCAGTACGGTTTCCCAAACCATGG >20663_20663_18_CUL3-AP1S3_CUL3_chr2_225400245_ENST00000409096_AP1S3_chr2_224642586_ENST00000446015_length(amino acids)=286AA_BP=0 MLRIHFFSFSFNLSHDVVLSVITEPSRCMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEH LINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSF VDWKELKLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIGGEIQETSKKIAVKAIEDSD -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for CUL3-AP1S3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | CUL3 | chr2:225400245 | chr2:224642586 | ENST00000264414 | - | 3 | 16 | 2_41 | 126.0 | 769.0 | KLHL18 |
| Hgene | CUL3 | chr2:225400245 | chr2:224642586 | ENST00000344951 | - | 2 | 15 | 2_41 | 60.0 | 703.0 | KLHL18 |
| Hgene | CUL3 | chr2:225400245 | chr2:224642586 | ENST00000409096 | - | 3 | 16 | 2_41 | 102.0 | 745.0 | KLHL18 |
| Hgene | CUL3 | chr2:225400245 | chr2:224642586 | ENST00000409777 | - | 3 | 16 | 2_41 | 102.0 | 745.0 | KLHL18 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CUL3-AP1S3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CUL3-AP1S3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CUL3 | C0025202 | melanoma | 1 | CTD_human |
| Hgene | CUL3 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | CUL3 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
| Hgene | CUL3 | C1535926 | Neurodevelopmental Disorders | 1 | CTD_human |
| Hgene | CUL3 | C3469606 | PSEUDOHYPOALDOSTERONISM, TYPE IIE | 1 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| Tgene | C4015235 | PSORIASIS 15, PUSTULAR, SUSCEPTIBILITY TO | 2 | GENOMICS_ENGLAND;UNIPROT | |
| Tgene | C0030246 | Pustulosis of Palms and Soles | 1 | CTD_human;ORPHANET | |
| Tgene | C0343055 | Generalized pustular psoriasis | 1 | ORPHANET | |
| Tgene | C0392439 | Acrodermatitis continua of Hallopeau | 1 | ORPHANET |
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