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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ATRN-TNKS2 (FusionGDB2 ID:HG8455TG80351) |
Fusion Gene Summary for ATRN-TNKS2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ATRN-TNKS2 | Fusion gene ID: hg8455tg80351 | Hgene | Tgene | Gene symbol | ATRN | TNKS2 | Gene ID | 8455 | 80351 |
| Gene name | attractin | tankyrase 2 | |
| Synonyms | DPPT-L|MGCA | ARTD6|PARP-5b|PARP-5c|PARP5B|PARP5C|TANK2|TNKL|pART6 | |
| Cytomap | ('ATRN')('TNKS2') 20p13 | 10q23.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | attractinattractin-2mahogany homologmahogany protein | poly [ADP-ribose] polymerase tankyrase-2ADP-ribosyltransferase diphtheria toxin-like 6TNKS-2TRF1-interacting ankyrin-related ADP-ribose polymerase 2poly [ADP-ribose] polymerase 5Bprotein poly-ADP-ribosyltransferase tankyrase-2tankyrase IItankyrase, | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000262919, ENST00000446916, | ||
| Fusion gene scores | * DoF score | 5 X 6 X 4=120 | 2 X 2 X 2=8 |
| # samples | 5 | 2 | |
| ** MAII score | log2(5/120*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: ATRN [Title/Abstract] AND TNKS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ATRN(3565527)-TNKS2(93572740), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | ATRN-TNKS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ATRN-TNKS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ATRN-TNKS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ATRN-TNKS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TNKS2 | GO:0000209 | protein polyubiquitination | 19759537|21478859 |
| Tgene | TNKS2 | GO:0006471 | protein ADP-ribosylation | 11739745 |
| Tgene | TNKS2 | GO:0070212 | protein poly-ADP-ribosylation | 25043379 |
| Tgene | TNKS2 | GO:0070213 | protein auto-ADP-ribosylation | 19759537|21478859 |
| Tgene | TNKS2 | GO:1904355 | positive regulation of telomere capping | 21531765 |
| Fusion gene breakpoints across ATRN (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across TNKS2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUSC | TCGA-56-8503-01A | ATRN | chr20 | 3565527 | - | TNKS2 | chr10 | 93572740 | + |
| ChimerDB4 | LUSC | TCGA-56-8503-01A | ATRN | chr20 | 3565527 | + | TNKS2 | chr10 | 93572740 | + |
| ChimerDB4 | LUSC | TCGA-56-8503 | ATRN | chr20 | 3565527 | + | TNKS2 | chr10 | 93572740 | + |
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Fusion Gene ORF analysis for ATRN-TNKS2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000262919 | ENST00000371627 | ATRN | chr20 | 3565527 | + | TNKS2 | chr10 | 93572740 | + |
| In-frame | ENST00000446916 | ENST00000371627 | ATRN | chr20 | 3565527 | + | TNKS2 | chr10 | 93572740 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000262919 | ATRN | chr20 | 3565527 | + | ENST00000371627 | TNKS2 | chr10 | 93572740 | + | 8831 | 3252 | 68 | 6553 | 2161 |
| ENST00000446916 | ATRN | chr20 | 3565527 | + | ENST00000371627 | TNKS2 | chr10 | 93572740 | + | 8763 | 3184 | 0 | 6485 | 2161 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000262919 | ENST00000371627 | ATRN | chr20 | 3565527 | + | TNKS2 | chr10 | 93572740 | + | 0.000162887 | 0.99983704 |
| ENST00000446916 | ENST00000371627 | ATRN | chr20 | 3565527 | + | TNKS2 | chr10 | 93572740 | + | 0.00015758 | 0.9998424 |
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Fusion Genomic Features for ATRN-TNKS2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| ATRN | chr20 | 3565527 | + | TNKS2 | chr10 | 93572739 | + | 0.000498966 | 0.999501 |
| ATRN | chr20 | 3565527 | + | TNKS2 | chr10 | 93572739 | + | 0.000498966 | 0.999501 |
| ATRN | chr20 | 3565527 | + | TNKS2 | chr10 | 93572739 | + | 0.000498966 | 0.999501 |
| ATRN | chr20 | 3565527 | + | TNKS2 | chr10 | 93572739 | + | 0.000498966 | 0.999501 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ATRN-TNKS2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:3565527/chr10:93572740) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000262919 | + | 18 | 29 | 43_77 | 1061 | 1430.0 | Compositional bias | Note=Leu-rich |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000446916 | + | 18 | 25 | 43_77 | 1061 | 1273.0 | Compositional bias | Note=Leu-rich |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000262919 | + | 18 | 29 | 101_129 | 1061 | 1430.0 | Domain | EGF-like |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000262919 | + | 18 | 29 | 132_248 | 1061 | 1430.0 | Domain | CUB |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000262919 | + | 18 | 29 | 703_748 | 1061 | 1430.0 | Domain | Note=PSI 1 |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000262919 | + | 18 | 29 | 755_794 | 1061 | 1430.0 | Domain | Note=PSI 2 |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000262919 | + | 18 | 29 | 795_919 | 1061 | 1430.0 | Domain | C-type lectin |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000262919 | + | 18 | 29 | 932_983 | 1061 | 1430.0 | Domain | Note=PSI 3 |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000262919 | + | 18 | 29 | 986_1061 | 1061 | 1430.0 | Domain | Note=PSI 4 |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000446916 | + | 18 | 25 | 101_129 | 1061 | 1273.0 | Domain | EGF-like |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000446916 | + | 18 | 25 | 132_248 | 1061 | 1273.0 | Domain | CUB |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000446916 | + | 18 | 25 | 703_748 | 1061 | 1273.0 | Domain | Note=PSI 1 |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000446916 | + | 18 | 25 | 755_794 | 1061 | 1273.0 | Domain | Note=PSI 2 |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000446916 | + | 18 | 25 | 795_919 | 1061 | 1273.0 | Domain | C-type lectin |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000446916 | + | 18 | 25 | 932_983 | 1061 | 1273.0 | Domain | Note=PSI 3 |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000446916 | + | 18 | 25 | 986_1061 | 1061 | 1273.0 | Domain | Note=PSI 4 |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000262919 | + | 18 | 29 | 352_402 | 1061 | 1430.0 | Repeat | Note=Kelch 1 |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000262919 | + | 18 | 29 | 404_451 | 1061 | 1430.0 | Repeat | Note=Kelch 2 |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000262919 | + | 18 | 29 | 461_508 | 1061 | 1430.0 | Repeat | Note=Kelch 3 |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000262919 | + | 18 | 29 | 513_564 | 1061 | 1430.0 | Repeat | Note=Kelch 4 |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000262919 | + | 18 | 29 | 566_624 | 1061 | 1430.0 | Repeat | Note=Kelch 5 |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000262919 | + | 18 | 29 | 625_671 | 1061 | 1430.0 | Repeat | Note=Kelch 6 |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000446916 | + | 18 | 25 | 352_402 | 1061 | 1273.0 | Repeat | Note=Kelch 1 |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000446916 | + | 18 | 25 | 404_451 | 1061 | 1273.0 | Repeat | Note=Kelch 2 |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000446916 | + | 18 | 25 | 461_508 | 1061 | 1273.0 | Repeat | Note=Kelch 3 |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000446916 | + | 18 | 25 | 513_564 | 1061 | 1273.0 | Repeat | Note=Kelch 4 |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000446916 | + | 18 | 25 | 566_624 | 1061 | 1273.0 | Repeat | Note=Kelch 5 |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000446916 | + | 18 | 25 | 625_671 | 1061 | 1273.0 | Repeat | Note=Kelch 6 |
| Tgene | TNKS2 | chr20:3565527 | chr10:93572740 | ENST00000371627 | 0 | 27 | 873_936 | 66 | 1167.0 | Domain | SAM | |
| Tgene | TNKS2 | chr20:3565527 | chr10:93572740 | ENST00000371627 | 0 | 27 | 959_1164 | 66 | 1167.0 | Domain | PARP catalytic | |
| Tgene | TNKS2 | chr20:3565527 | chr10:93572740 | ENST00000371627 | 0 | 27 | 545_553 | 66 | 1167.0 | Region | HIF1AN-binding | |
| Tgene | TNKS2 | chr20:3565527 | chr10:93572740 | ENST00000371627 | 0 | 27 | 123_155 | 66 | 1167.0 | Repeat | Note=ANK 3 | |
| Tgene | TNKS2 | chr20:3565527 | chr10:93572740 | ENST00000371627 | 0 | 27 | 210_242 | 66 | 1167.0 | Repeat | Note=ANK 4 | |
| Tgene | TNKS2 | chr20:3565527 | chr10:93572740 | ENST00000371627 | 0 | 27 | 243_275 | 66 | 1167.0 | Repeat | Note=ANK 5 | |
| Tgene | TNKS2 | chr20:3565527 | chr10:93572740 | ENST00000371627 | 0 | 27 | 276_308 | 66 | 1167.0 | Repeat | Note=ANK 6 | |
| Tgene | TNKS2 | chr20:3565527 | chr10:93572740 | ENST00000371627 | 0 | 27 | 363_398 | 66 | 1167.0 | Repeat | Note=ANK 7 | |
| Tgene | TNKS2 | chr20:3565527 | chr10:93572740 | ENST00000371627 | 0 | 27 | 399_431 | 66 | 1167.0 | Repeat | Note=ANK 8 | |
| Tgene | TNKS2 | chr20:3565527 | chr10:93572740 | ENST00000371627 | 0 | 27 | 432_464 | 66 | 1167.0 | Repeat | Note=ANK 9 | |
| Tgene | TNKS2 | chr20:3565527 | chr10:93572740 | ENST00000371627 | 0 | 27 | 525_557 | 66 | 1167.0 | Repeat | Note=ANK 10 | |
| Tgene | TNKS2 | chr20:3565527 | chr10:93572740 | ENST00000371627 | 0 | 27 | 558_590 | 66 | 1167.0 | Repeat | Note=ANK 11 | |
| Tgene | TNKS2 | chr20:3565527 | chr10:93572740 | ENST00000371627 | 0 | 27 | 591_623 | 66 | 1167.0 | Repeat | Note=ANK 12 | |
| Tgene | TNKS2 | chr20:3565527 | chr10:93572740 | ENST00000371627 | 0 | 27 | 678_710 | 66 | 1167.0 | Repeat | Note=ANK 13 | |
| Tgene | TNKS2 | chr20:3565527 | chr10:93572740 | ENST00000371627 | 0 | 27 | 711_743 | 66 | 1167.0 | Repeat | Note=ANK 14 | |
| Tgene | TNKS2 | chr20:3565527 | chr10:93572740 | ENST00000371627 | 0 | 27 | 744_776 | 66 | 1167.0 | Repeat | Note=ANK 15 | |
| Tgene | TNKS2 | chr20:3565527 | chr10:93572740 | ENST00000371627 | 0 | 27 | 90_122 | 66 | 1167.0 | Repeat | Note=ANK 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000262919 | + | 18 | 29 | 1063_1108 | 1061 | 1430.0 | Domain | Laminin EGF-like 1 |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000262919 | + | 18 | 29 | 1109_1157 | 1061 | 1430.0 | Domain | Laminin EGF-like 2 |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000446916 | + | 18 | 25 | 1063_1108 | 1061 | 1273.0 | Domain | Laminin EGF-like 1 |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000446916 | + | 18 | 25 | 1109_1157 | 1061 | 1273.0 | Domain | Laminin EGF-like 2 |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000262919 | + | 18 | 29 | 1301_1429 | 1061 | 1430.0 | Topological domain | Cytoplasmic |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000262919 | + | 18 | 29 | 84_1279 | 1061 | 1430.0 | Topological domain | Extracellular |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000446916 | + | 18 | 25 | 1301_1429 | 1061 | 1273.0 | Topological domain | Cytoplasmic |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000446916 | + | 18 | 25 | 84_1279 | 1061 | 1273.0 | Topological domain | Extracellular |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000262919 | + | 18 | 29 | 1280_1300 | 1061 | 1430.0 | Transmembrane | Helical |
| Hgene | ATRN | chr20:3565527 | chr10:93572740 | ENST00000446916 | + | 18 | 25 | 1280_1300 | 1061 | 1273.0 | Transmembrane | Helical |
| Tgene | TNKS2 | chr20:3565527 | chr10:93572740 | ENST00000371627 | 0 | 27 | 57_89 | 66 | 1167.0 | Repeat | Note=ANK 1 |
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Fusion Gene Sequence for ATRN-TNKS2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >8336_8336_1_ATRN-TNKS2_ATRN_chr20_3565527_ENST00000262919_TNKS2_chr10_93572740_ENST00000371627_length(transcript)=8831nt_BP=3252nt GGCGAAGCGGAGCCGGCCGTGCGGTGTGTGTGTATGTGTTCGCGGGGCGCCGTCTCAGCCCCGGGAAGATGGTGGCTGCAGCGGCGGCAA CTGAGGCAAGGCTGAGGAGGAGGACGGCGGCGACGGCAGCGCTCGCGGGCAGGAGCGGCGGGCCGCACTGGGACTGGGACGTGACCAGGG CTGGGAGGCCGGGGCTGGGGGCCGGGCTGCGCCTCCCGCGGCTGCTGTCTCCACCGCTGCGGCCACGGCTGCTGCTGCTGCTGTTGTTGC TCTCGCCGCCGCTGCTGCTGCTGCTGCTGCCCTGTGAGGCCGAGGCCGCGGCGGCGGCGGCGGCGGTGTCGGGCTCAGCCGCAGCCGAGG CCAAGGAATGTGACCGGCCCTGTGTCAACGGCGGTCGCTGCAACCCTGGCACCGGCCAGTGCGTCTGCCCCGCCGGCTGGGTGGGCGAGC AATGCCAGCACTGCGGGGGCCGCTTCAGACTAACTGGATCTTCTGGGTTTGTGACAGATGGACCTGGAAATTATAAATACAAAACGAAGT GCACGTGGCTCATTGAAGGACAGCCAAATAGAATAATGAGACTTCGTTTCAATCATTTTGCTACAGAGTGTAGTTGGGACCATTTATATG TTTATGATGGGGACTCAATTTATGCACCGCTAGTTGCTGCATTTAGTGGCCTCATTGTTCCTGAGAGAGATGGCAATGAGACTGTCCCTG AGGTTGTTGCCACATCAGGTTATGCCTTGCTGCATTTTTTTAGTGATGCTGCTTATAATTTGACTGGATTTAATATTACTTACAGTTTTG ATATGTGTCCAAATAACTGCTCAGGCCGAGGAGAGTGTAAGATCAGTAATAGCAGCGATACTGTTGAATGTGAATGTTCTGAAAACTGGA AAGGTGAAGCATGTGACATTCCTCACTGTACAGACAACTGTGGTTTTCCTCATCGAGGCATCTGCAATTCAAGTGATGTCAGAGGATGCT CCTGCTTCTCAGACTGGCAGGGTCCTGGATGTTCAGTTCCTGTACCAGCTAACCAGTCATTTTGGACTCGAGAGGAATATTCTAACTTAA AGCTCCCCAGAGCATCTCATAAAGCTGTGGTCAATGGAAACATTATGTGGGTTGTTGGAGGATATATGTTCAACCACTCAGATTATAACA TGGTTCTAGCGTATGACCTTGCTTCTAGGGAGTGGCTTCCACTAAACCGTTCTGTGAACAATGTGGTTGTTAGATATGGTCATTCTTTGG CATTATACAAGGATAAAATTTACATGTATGGAGGAAAAATTGATTCAACTGGGAATGTGACCAATGAGTTGAGAGTTTTTCACATTCATA ATGAGTCATGGGTGTTGTTGACCCCTAAGGCAAAGGAGCAGTATGCAGTGGTTGGGCACTCTGCACACATTGTTACACTGAAGAATGGCC GAGTGGTCATGCTGGTCATCTTTGGTCACTGCCCTCTCTATGGATATATAAGCAATGTGCAGGAATATGATTTGGATAAGAACACATGGA GTATATTACACACCCAGGGTGCCCTTGTGCAAGGGGGTTACGGCCATAGCAGTGTTTACGACCATAGGACCAGGGCCCTATACGTTCATG GTGGCTACAAGGCTTTCAGTGCCAATAAGTACCGGCTTGCAGATGATCTCTACCGATATGATGTGGATACCCAGATGTGGACCATTCTTA AGGACAGCCGATTTTTCCGTTACTTGCACACAGCTGTGATAGTGAGTGGAACCATGCTGGTGTTTGGAGGAAACACACACAATGACACAT CTATGAGCCATGGCGCCAAATGCTTCTCTTCAGATTTCATGGCCTATGACATTGCCTGTGACCGCTGGTCAGTGCTTCCCAGACCTGATC TCCACCATGATGTCAACAGATTTGGCCATTCAGCAGTCTTACACAACAGCACCATGTATGTGTTCGGTGGTTTCAATAGTCTCCTCCTCA GCGACATCCTGGTATTCACCTCGGAACAGTGTGATGCGCATCGGAGTGAAGCCGCTTGTTTAGCAGCAGGACCTGGTATTCGGTGTGTGT GGAACACAGGGTCGTCTCAGTGTATCTCGTGGGCGCTGGCAACTGATGAACAAGAAGAAAAGTTAAAATCAGAATGTTTTTCCAAAAGAA CTCTTGACCATGACAGATGTGACCAGCACACAGATTGTTACAGCTGCACAGCCAACACCAATGACTGCCACTGGTGCAATGACCATTGTG TCCCCAGGAACCACAGCTGCTCAGAAGGCCAGATCTCCATTTTTAGGTATGAGAATTGCCCCAAGGATAACCCCATGTACTACTGTAACA AGAAGACCAGCTGCAGGAGCTGTGCCCTGGACCAGAACTGCCAGTGGGAGCCCCGGAATCAGGAGTGCATTGCCCTGCCCGAAAATATCT GTGGCATTGGCTGGCATTTGGTTGGAAACTCATGTTTGAAAATTACTACTGCCAAGGAGAATTATGACAATGCTAAATTGTTCTGTAGGA ACCACAATGCCCTTTTGGCTTCTCTTACAACCCAGAAGAAGGTAGAATTTGTCCTTAAGCAGCTGCGAATAATGCAGTCATCTCAGAGCA TGTCCAAGCTCACCTTAACCCCATGGGTCGGCCTTCGGAAGATCAATGTGTCCTACTGGTGCTGGGAAGATATGTCCCCATTTACAAATA GTTTACTACAGTGGATGCCGTCTGAGCCCAGTGATGCTGGATTCTGTGGAATTTTATCAGAACCCAGTACTCGGGGACTGAAGGCTGCAA CCTGCATCAACCCACTCAATGGTAGTGTCTGTGAAAGGCCTGCAAACCACAGTGCTAAGCAGTGCCGGACACCATGTGCCTTGAGGACAG CATGTGGAGATTGCACCAGCGGCAGCTCTGAGTGCATGTGGTGCAGCAACATGAAGCAGTGTGTGGACTCCAATGCCTACGTGGCCTCCT TCCCTTTTGGCCAGTGTATGGAATGGTATACGATGAGCACCTGCCCCCCTGAAAATTGTTCAGGCTACTGTACCTGTAGTCATTGCTTGG AGCAACCAGGCTGTGGCTGGTGTACTGATCCCAGCAATACTGGCAAAGGGAAATGCATAGAGGGTTCCTATAAAGGACCAGTGAAGATGC CTTCGCAAGCCCCTACAGGAAATTTCTATCCACAGCCCCTGCTCAATTCCAGCATGTGTCTAGAGGACAGCAGATACAACTGGTCTTTCA TTCACTGTCCAGGTTTTGGGCGGAAAGACGTAGTTGAATATTTGCTTCAGAATGGTGCAAATGTCCAAGCACGTGATGATGGGGGCCTTA TTCCTCTTCATAATGCATGCTCTTTTGGTCATGCTGAAGTAGTCAATCTCCTTTTGCGACATGGTGCAGACCCCAATGCTCGAGATAATT GGAATTATACTCCTCTCCATGAAGCTGCAATTAAAGGAAAGATTGATGTTTGCATTGTGCTGTTACAGCATGGAGCTGAGCCAACCATCC GAAATACAGATGGAAGGACAGCATTGGATTTAGCAGATCCATCTGCCAAAGCAGTGCTTACTGGTGAATATAAGAAAGATGAACTCTTAG AAAGTGCCAGGAGTGGCAATGAAGAAAAAATGATGGCTCTACTCACACCATTAAATGTCAACTGCCACGCAAGTGATGGCAGAAAGTCAA CTCCATTACATTTGGCAGCAGGATATAACAGAGTAAAGATTGTACAGCTGTTACTGCAACATGGAGCTGATGTCCATGCTAAAGATAAAG GTGATCTGGTACCATTACACAATGCCTGTTCTTATGGTCATTATGAAGTAACTGAACTTTTGGTCAAGCATGGTGCCTGTGTAAATGCAA TGGACTTGTGGCAATTCACTCCTCTTCATGAGGCAGCTTCTAAGAACAGGGTTGAAGTATGTTCTCTTCTCTTAAGTTATGGTGCAGACC CAACACTGCTCAATTGTCACAATAAAAGTGCTATAGACTTGGCTCCCACACCACAGTTAAAAGAAAGATTAGCATATGAATTTAAAGGCC ACTCGTTGCTGCAAGCTGCACGAGAAGCTGATGTTACTCGAATCAAAAAACATCTCTCTCTGGAAATGGTGAATTTCAAGCATCCTCAAA CACATGAAACAGCATTGCATTGTGCTGCTGCATCTCCATATCCCAAAAGAAAGCAAATATGTGAACTGTTGCTAAGAAAAGGAGCAAACA TCAATGAAAAGACTAAAGAATTCTTGACTCCTCTGCACGTGGCATCTGAGAAAGCTCATAATGATGTTGTTGAAGTAGTGGTGAAACATG AAGCAAAGGTTAATGCTCTGGATAATCTTGGTCAGACTTCTCTACACAGAGCTGCATATTGTGGTCATCTACAAACCTGCCGCCTACTCC TGAGCTATGGGTGTGATCCTAACATTATATCCCTTCAGGGCTTTACTGCTTTACAGATGGGAAATGAAAATGTACAGCAACTCCTCCAAG AGGGTATCTCATTAGGTAATTCAGAGGCAGACAGACAATTGCTGGAAGCTGCAAAGGCTGGAGATGTCGAAACTGTAAAAAAACTGTGTA CTGTTCAGAGTGTCAACTGCAGAGACATTGAAGGGCGTCAGTCTACACCACTTCATTTTGCAGCTGGGTATAACAGAGTGTCCGTGGTGG AATATCTGCTACAGCATGGAGCTGATGTGCATGCTAAAGATAAAGGAGGCCTTGTACCTTTGCACAATGCATGTTCTTATGGACATTATG AAGTTGCAGAACTTCTTGTTAAACATGGAGCAGTAGTTAATGTAGCTGATTTATGGAAATTTACACCTTTACATGAAGCAGCAGCAAAAG GAAAATATGAAATTTGCAAACTTCTGCTCCAGCATGGTGCAGACCCTACAAAAAAAAACAGGGATGGAAATACTCCTTTGGATCTTGTTA AAGATGGAGATACAGATATTCAAGATCTGCTTAGGGGAGATGCAGCTTTGCTAGATGCTGCCAAGAAGGGTTGTTTAGCCAGAGTGAAGA AGTTGTCTTCTCCTGATAATGTAAATTGCCGCGATACCCAAGGCAGACATTCAACACCTTTACATTTAGCAGCTGGTTATAATAATTTAG AAGTTGCAGAGTATTTGTTACAACACGGAGCTGATGTGAATGCCCAAGACAAAGGAGGACTTATTCCTTTACATAATGCAGCATCTTACG GGCATGTAGATGTAGCAGCTCTACTAATAAAGTATAATGCATGTGTCAATGCCACGGACAAATGGGCTTTCACACCTTTGCACGAAGCAG CCCAAAAGGGACGAACACAGCTTTGTGCTTTGTTGCTAGCCCATGGAGCTGACCCGACTCTTAAAAATCAGGAAGGACAAACACCTTTAG ATTTAGTTTCAGCGGATGATGTCAGCGCTCTTCTGACAGCAGCCATGCCCCCATCTGCTCTGCCCTCTTGTTACAAGCCTCAAGTGCTCA ATGGTGTGAGAAGCCCAGGAGCCACTGCAGATGCTCTCTCTTCAGGTCCATCTAGCCCATCAAGCCTTTCTGCAGCCAGCAGTCTTGACA ACTTATCTGGGAGTTTTTCAGAACTGTCTTCAGTAGTTAGTTCAAGTGGAACAGAGGGTGCTTCCAGTTTGGAGAAAAAGGAGGTTCCAG GAGTAGATTTTAGCATAACTCAATTCGTAAGGAATCTTGGACTTGAGCACCTAATGGATATATTTGAGAGAGAACAGATCACTTTGGATG TATTAGTTGAGATGGGGCACAAGGAGCTGAAGGAGATTGGAATCAATGCTTATGGACATAGGCACAAACTAATTAAAGGAGTCGAGAGAC TTATCTCCGGACAACAAGGTCTTAACCCATATTTAACTTTGAACACCTCTGGTAGTGGAACAATTCTTATAGATCTGTCTCCTGATGATA AAGAGTTTCAGTCTGTGGAGGAAGAGATGCAAAGTACAGTTCGAGAGCACAGAGATGGAGGTCATGCAGGTGGAATCTTCAACAGATACA ATATTCTCAAGATTCAGAAGGTTTGTAACAAGAAACTATGGGAAAGATACACTCACCGGAGAAAAGAAGTTTCTGAAGAAAACCACAACC ATGCCAATGAACGAATGCTATTTCATGGGTCTCCTTTTGTGAATGCAATTATCCACAAAGGCTTTGATGAAAGGCATGCGTACATAGGTG GTATGTTTGGAGCTGGCATTTATTTTGCTGAAAACTCTTCCAAAAGCAATCAATATGTATATGGAATTGGAGGAGGTACTGGGTGTCCAG TTCACAAAGACAGATCTTGTTACATTTGCCACAGGCAGCTGCTCTTTTGCCGGGTAACCTTGGGAAAGTCTTTCCTGCAGTTCAGTGCAA TGAAAATGGCACATTCTCCTCCAGGTCATCACTCAGTCACTGGTAGGCCCAGTGTAAATGGCCTAGCATTAGCTGAATATGTTATTTACA GAGGAGAACAGGCTTATCCTGAGTATTTAATTACTTACCAGATTATGAGGCCTGAAGGTATGGTCGATGGATAAATAGTTATTTTAAGAA ACTAATTCCACTGAACCTAAAATCATCAAAGCAGCAGTGGCCTCTACGTTTTACTCCTTTGCTGAAAAAAAATCATCTTGCCCACAGGCC TGTGGCAAAAGGATAAAAATGTGAACGAAGTTTAACATTCTGACTTGATAAAGCTTTAATAATGTACAGTGTTTTCTAAATATTTCCTGT TTTTTCAGCACTTTAACAGATGCCATTCCAGGTTAAACTGGGTTGTCTGTACTAAATTATAAACAGAGTTAACTTGAACCTTTTATATGT TATGCATTGATTCTAACAAACTGTAATGCCCTCAACAGAACTAATTTTACTAATACAATACTGTGTTCTTTAAAACACAGCATTTACACT GAATACAATTTCATTTGTAAAACTGTAAATAAGAGCTTTTGTACTAGCCCAGTATTTATTTACATTGCTTTGTAATATAAATCTGTTTTA GAACTGCAGCGGTTTACAAAATTTTTTCATATGTATTGTTCATCTATACTTCATCTTACATCGTCATGATTGAGTGATCTTTACATTTGA TTCCAGAGGCTATGTTCAGTTGTTAGTTGGGAAAGATTGAGTTATCAGATTTAATTTGCCGATGGGAGCCTTTATCTGTCATTAGAAATC TTTCTCATTTAAGAACTTATGAATATGCTGAAGATTTAATTTGTGATACCTTTGTATGTATGAGACACATTCCAAAGAGCTCTAACTATG ATAGGTCCTGATTACTAAAGAAGCTTCTTTACTGGCCTCAATTTCTAGCTTTCATGTTGGAAAATTTTCTGCAGTCCTTCTGTGAAAATT AGAGCAAAGTGCTCCTGTTTTTTAGAGAAACTAAATCTTGCTGTTGAACAATTATTGTGTTCTTTTCATGGAACATAAGTAGGATGTTAC ATTTCCAGGGTGGGAAGGGTAATCCTAAATCATTTCCCAATCTATTCTAATTACCTTAAATCTAAAGGGGAAAAAAAAAATCACAAACAG GACTGGGTAGTTTTTTATCCTAAGTATATTTTTTCCTGTTCTTTTTACTTGGTTTTATTGCTGTATTTATAGCCAATCTATACATCATGG GTAAACTTAACCCAGAACTATAAAATGTAGTTGTCTCAGTCCCCTCCAGGCCTCCTGAATGGGCAAGTGCAGTGAAACAGGTGCTTCTTG CTCCTGGGTTTTCTCTCCATGATGTTATGCCCAATTGGAAATATGCTGTCAGTTTGTGCACCATATGGTGACCACGCCTGTGCTCAGTTT GGCAGCTATAGAAGGAAATGCTGTCCCATAAAATGCCATTCCTATTTTCTAATATAAAACTCTTTTCCAGGAAGCATGCTTAAGCATCTT GTTACAGAGACATACATCCATTATGGCTTGGCAATCTCTTTTATTTGTTGACTCTAGCTCCCTTCAAAGTCGAGGAAAGATCTTTACTCA CTTAATGAGGACATTCCCCATCACTGTCTGTACCAGTTCACCTTTATTTTACGTTTTATTCAGTCTGTAAATTAACTGGCCCTTTGCAGT AACTTGTACATAAAGTGCTAGAAAATCATGTTCCTTGTCCTGAGTAAGAGTTAATCAGAGTAAATGCATTTCTGGAGTTGTTTCTGTGAT GTAAATTATGATCATTATTTAAGAAGTCAAATCCTGATCTTGAAGTGCTTTTTATACAGCTCTCTAATAATTACAAATATCCGAAAGTCA TTTCTTGGAACACAAGTGGAGTATGCCAAATTTTATATGAATTTTTCAGATTATCTAAGCTTCCAGGTTTTATAATTAGAAGATAATGAG AGAATTAATGGGGTTTATATTTACATTATCTCTCAACTATGTAGCCCATATTACTCACCCTATGAGTGAATCTGGAATTGCTTTTCATGT GAAATCATTGTGGTCTATGAGTTTACAATACTGCAAACTGTGTTATTTTATCTAATCCATTGCTTAATGAGTGTGTTTTTCCATGAATGA ATATACCGTGGTTCATATGTTAGCATGGCAGCATTTTCAGATAGCTTTTTGTTTGTTGGGAAGTTGGGGTTTTGGGGGGAGGGGGAGTAT TAGTACGTTGCATGAAATAGCTTACTTTATAATGATGGAATTGCTTTTTCTTTTGTCTTGTGATTTTTTTTTTTGAAGTGAAATTTAACT TTTTGTGCAAGTAGTACTATTATACCCATCTTCAGTGTCTTACTTGTACTGTATCACATTCCATACCCTCATTTAATTCTTAATAAAACT >8336_8336_1_ATRN-TNKS2_ATRN_chr20_3565527_ENST00000262919_TNKS2_chr10_93572740_ENST00000371627_length(amino acids)=2161AA_BP=1486 MVAAAAATEARLRRRTAATAALAGRSGGPHWDWDVTRAGRPGLGAGLRLPRLLSPPLRPRLLLLLLLLSPPLLLLLLPCEAEAAAAAAAV SGSAAAEAKECDRPCVNGGRCNPGTGQCVCPAGWVGEQCQHCGGRFRLTGSSGFVTDGPGNYKYKTKCTWLIEGQPNRIMRLRFNHFATE CSWDHLYVYDGDSIYAPLVAAFSGLIVPERDGNETVPEVVATSGYALLHFFSDAAYNLTGFNITYSFDMCPNNCSGRGECKISNSSDTVE CECSENWKGEACDIPHCTDNCGFPHRGICNSSDVRGCSCFSDWQGPGCSVPVPANQSFWTREEYSNLKLPRASHKAVVNGNIMWVVGGYM FNHSDYNMVLAYDLASREWLPLNRSVNNVVVRYGHSLALYKDKIYMYGGKIDSTGNVTNELRVFHIHNESWVLLTPKAKEQYAVVGHSAH IVTLKNGRVVMLVIFGHCPLYGYISNVQEYDLDKNTWSILHTQGALVQGGYGHSSVYDHRTRALYVHGGYKAFSANKYRLADDLYRYDVD TQMWTILKDSRFFRYLHTAVIVSGTMLVFGGNTHNDTSMSHGAKCFSSDFMAYDIACDRWSVLPRPDLHHDVNRFGHSAVLHNSTMYVFG GFNSLLLSDILVFTSEQCDAHRSEAACLAAGPGIRCVWNTGSSQCISWALATDEQEEKLKSECFSKRTLDHDRCDQHTDCYSCTANTNDC HWCNDHCVPRNHSCSEGQISIFRYENCPKDNPMYYCNKKTSCRSCALDQNCQWEPRNQECIALPENICGIGWHLVGNSCLKITTAKENYD NAKLFCRNHNALLASLTTQKKVEFVLKQLRIMQSSQSMSKLTLTPWVGLRKINVSYWCWEDMSPFTNSLLQWMPSEPSDAGFCGILSEPS TRGLKAATCINPLNGSVCERPANHSAKQCRTPCALRTACGDCTSGSSECMWCSNMKQCVDSNAYVASFPFGQCMEWYTMSTCPPENCSGY CTCSHCLEQPGCGWCTDPSNTGKGKCIEGSYKGPVKMPSQAPTGNFYPQPLLNSSMCLEDSRYNWSFIHCPGFGRKDVVEYLLQNGANVQ ARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGE YKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEM VNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGH LQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAG YNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDG NTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIP LHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSALPS CYKPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSSGTEGASSLEKKEVPGVDFSITQFVRNLGLEHLMDIFE REQITLDVLVEMGHKELKEIGINAYGHRHKLIKGVERLISGQQGLNPYLTLNTSGSGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHA GGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGI GGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPEGMVD -------------------------------------------------------------- >8336_8336_2_ATRN-TNKS2_ATRN_chr20_3565527_ENST00000446916_TNKS2_chr10_93572740_ENST00000371627_length(transcript)=8763nt_BP=3184nt ATGGTGGCTGCAGCGGCGGCAACTGAGGCAAGGCTGAGGAGGAGGACGGCGGCGACGGCAGCGCTCGCGGGCAGGAGCGGCGGGCCGCAC TGGGACTGGGACGTGACCAGGGCTGGGAGGCCGGGGCTGGGGGCCGGGCTGCGCCTCCCGCGGCTGCTGTCTCCACCGCTGCGGCCACGG CTGCTGCTGCTGCTGTTGTTGCTCTCGCCGCCGCTGCTGCTGCTGCTGCTGCCCTGTGAGGCCGAGGCCGCGGCGGCGGCGGCGGCGGTG TCGGGCTCAGCCGCAGCCGAGGCCAAGGAATGTGACCGGCCCTGTGTCAACGGCGGTCGCTGCAACCCTGGCACCGGCCAGTGCGTCTGC CCCGCCGGCTGGGTGGGCGAGCAATGCCAGCACTGCGGGGGCCGCTTCAGACTAACTGGATCTTCTGGGTTTGTGACAGATGGACCTGGA AATTATAAATACAAAACGAAGTGCACGTGGCTCATTGAAGGACAGCCAAATAGAATAATGAGACTTCGTTTCAATCATTTTGCTACAGAG TGTAGTTGGGACCATTTATATGTTTATGATGGGGACTCAATTTATGCACCGCTAGTTGCTGCATTTAGTGGCCTCATTGTTCCTGAGAGA GATGGCAATGAGACTGTCCCTGAGGTTGTTGCCACATCAGGTTATGCCTTGCTGCATTTTTTTAGTGATGCTGCTTATAATTTGACTGGA TTTAATATTACTTACAGTTTTGATATGTGTCCAAATAACTGCTCAGGCCGAGGAGAGTGTAAGATCAGTAATAGCAGCGATACTGTTGAA TGTGAATGTTCTGAAAACTGGAAAGGTGAAGCATGTGACATTCCTCACTGTACAGACAACTGTGGTTTTCCTCATCGAGGCATCTGCAAT TCAAGTGATGTCAGAGGATGCTCCTGCTTCTCAGACTGGCAGGGTCCTGGATGTTCAGTTCCTGTACCAGCTAACCAGTCATTTTGGACT CGAGAGGAATATTCTAACTTAAAGCTCCCCAGAGCATCTCATAAAGCTGTGGTCAATGGAAACATTATGTGGGTTGTTGGAGGATATATG TTCAACCACTCAGATTATAACATGGTTCTAGCGTATGACCTTGCTTCTAGGGAGTGGCTTCCACTAAACCGTTCTGTGAACAATGTGGTT GTTAGATATGGTCATTCTTTGGCATTATACAAGGATAAAATTTACATGTATGGAGGAAAAATTGATTCAACTGGGAATGTGACCAATGAG TTGAGAGTTTTTCACATTCATAATGAGTCATGGGTGTTGTTGACCCCTAAGGCAAAGGAGCAGTATGCAGTGGTTGGGCACTCTGCACAC ATTGTTACACTGAAGAATGGCCGAGTGGTCATGCTGGTCATCTTTGGTCACTGCCCTCTCTATGGATATATAAGCAATGTGCAGGAATAT GATTTGGATAAGAACACATGGAGTATATTACACACCCAGGGTGCCCTTGTGCAAGGGGGTTACGGCCATAGCAGTGTTTACGACCATAGG ACCAGGGCCCTATACGTTCATGGTGGCTACAAGGCTTTCAGTGCCAATAAGTACCGGCTTGCAGATGATCTCTACCGATATGATGTGGAT ACCCAGATGTGGACCATTCTTAAGGACAGCCGATTTTTCCGTTACTTGCACACAGCTGTGATAGTGAGTGGAACCATGCTGGTGTTTGGA GGAAACACACACAATGACACATCTATGAGCCATGGCGCCAAATGCTTCTCTTCAGATTTCATGGCCTATGACATTGCCTGTGACCGCTGG TCAGTGCTTCCCAGACCTGATCTCCACCATGATGTCAACAGATTTGGCCATTCAGCAGTCTTACACAACAGCACCATGTATGTGTTCGGT GGTTTCAATAGTCTCCTCCTCAGCGACATCCTGGTATTCACCTCGGAACAGTGTGATGCGCATCGGAGTGAAGCCGCTTGTTTAGCAGCA GGACCTGGTATTCGGTGTGTGTGGAACACAGGGTCGTCTCAGTGTATCTCGTGGGCGCTGGCAACTGATGAACAAGAAGAAAAGTTAAAA TCAGAATGTTTTTCCAAAAGAACTCTTGACCATGACAGATGTGACCAGCACACAGATTGTTACAGCTGCACAGCCAACACCAATGACTGC CACTGGTGCAATGACCATTGTGTCCCCAGGAACCACAGCTGCTCAGAAGGCCAGATCTCCATTTTTAGGTATGAGAATTGCCCCAAGGAT AACCCCATGTACTACTGTAACAAGAAGACCAGCTGCAGGAGCTGTGCCCTGGACCAGAACTGCCAGTGGGAGCCCCGGAATCAGGAGTGC ATTGCCCTGCCCGAAAATATCTGTGGCATTGGCTGGCATTTGGTTGGAAACTCATGTTTGAAAATTACTACTGCCAAGGAGAATTATGAC AATGCTAAATTGTTCTGTAGGAACCACAATGCCCTTTTGGCTTCTCTTACAACCCAGAAGAAGGTAGAATTTGTCCTTAAGCAGCTGCGA ATAATGCAGTCATCTCAGAGCATGTCCAAGCTCACCTTAACCCCATGGGTCGGCCTTCGGAAGATCAATGTGTCCTACTGGTGCTGGGAA GATATGTCCCCATTTACAAATAGTTTACTACAGTGGATGCCGTCTGAGCCCAGTGATGCTGGATTCTGTGGAATTTTATCAGAACCCAGT ACTCGGGGACTGAAGGCTGCAACCTGCATCAACCCACTCAATGGTAGTGTCTGTGAAAGGCCTGCAAACCACAGTGCTAAGCAGTGCCGG ACACCATGTGCCTTGAGGACAGCATGTGGAGATTGCACCAGCGGCAGCTCTGAGTGCATGTGGTGCAGCAACATGAAGCAGTGTGTGGAC TCCAATGCCTACGTGGCCTCCTTCCCTTTTGGCCAGTGTATGGAATGGTATACGATGAGCACCTGCCCCCCTGAAAATTGTTCAGGCTAC TGTACCTGTAGTCATTGCTTGGAGCAACCAGGCTGTGGCTGGTGTACTGATCCCAGCAATACTGGCAAAGGGAAATGCATAGAGGGTTCC TATAAAGGACCAGTGAAGATGCCTTCGCAAGCCCCTACAGGAAATTTCTATCCACAGCCCCTGCTCAATTCCAGCATGTGTCTAGAGGAC AGCAGATACAACTGGTCTTTCATTCACTGTCCAGGTTTTGGGCGGAAAGACGTAGTTGAATATTTGCTTCAGAATGGTGCAAATGTCCAA GCACGTGATGATGGGGGCCTTATTCCTCTTCATAATGCATGCTCTTTTGGTCATGCTGAAGTAGTCAATCTCCTTTTGCGACATGGTGCA GACCCCAATGCTCGAGATAATTGGAATTATACTCCTCTCCATGAAGCTGCAATTAAAGGAAAGATTGATGTTTGCATTGTGCTGTTACAG CATGGAGCTGAGCCAACCATCCGAAATACAGATGGAAGGACAGCATTGGATTTAGCAGATCCATCTGCCAAAGCAGTGCTTACTGGTGAA TATAAGAAAGATGAACTCTTAGAAAGTGCCAGGAGTGGCAATGAAGAAAAAATGATGGCTCTACTCACACCATTAAATGTCAACTGCCAC GCAAGTGATGGCAGAAAGTCAACTCCATTACATTTGGCAGCAGGATATAACAGAGTAAAGATTGTACAGCTGTTACTGCAACATGGAGCT GATGTCCATGCTAAAGATAAAGGTGATCTGGTACCATTACACAATGCCTGTTCTTATGGTCATTATGAAGTAACTGAACTTTTGGTCAAG CATGGTGCCTGTGTAAATGCAATGGACTTGTGGCAATTCACTCCTCTTCATGAGGCAGCTTCTAAGAACAGGGTTGAAGTATGTTCTCTT CTCTTAAGTTATGGTGCAGACCCAACACTGCTCAATTGTCACAATAAAAGTGCTATAGACTTGGCTCCCACACCACAGTTAAAAGAAAGA TTAGCATATGAATTTAAAGGCCACTCGTTGCTGCAAGCTGCACGAGAAGCTGATGTTACTCGAATCAAAAAACATCTCTCTCTGGAAATG GTGAATTTCAAGCATCCTCAAACACATGAAACAGCATTGCATTGTGCTGCTGCATCTCCATATCCCAAAAGAAAGCAAATATGTGAACTG TTGCTAAGAAAAGGAGCAAACATCAATGAAAAGACTAAAGAATTCTTGACTCCTCTGCACGTGGCATCTGAGAAAGCTCATAATGATGTT GTTGAAGTAGTGGTGAAACATGAAGCAAAGGTTAATGCTCTGGATAATCTTGGTCAGACTTCTCTACACAGAGCTGCATATTGTGGTCAT CTACAAACCTGCCGCCTACTCCTGAGCTATGGGTGTGATCCTAACATTATATCCCTTCAGGGCTTTACTGCTTTACAGATGGGAAATGAA AATGTACAGCAACTCCTCCAAGAGGGTATCTCATTAGGTAATTCAGAGGCAGACAGACAATTGCTGGAAGCTGCAAAGGCTGGAGATGTC GAAACTGTAAAAAAACTGTGTACTGTTCAGAGTGTCAACTGCAGAGACATTGAAGGGCGTCAGTCTACACCACTTCATTTTGCAGCTGGG TATAACAGAGTGTCCGTGGTGGAATATCTGCTACAGCATGGAGCTGATGTGCATGCTAAAGATAAAGGAGGCCTTGTACCTTTGCACAAT GCATGTTCTTATGGACATTATGAAGTTGCAGAACTTCTTGTTAAACATGGAGCAGTAGTTAATGTAGCTGATTTATGGAAATTTACACCT TTACATGAAGCAGCAGCAAAAGGAAAATATGAAATTTGCAAACTTCTGCTCCAGCATGGTGCAGACCCTACAAAAAAAAACAGGGATGGA AATACTCCTTTGGATCTTGTTAAAGATGGAGATACAGATATTCAAGATCTGCTTAGGGGAGATGCAGCTTTGCTAGATGCTGCCAAGAAG GGTTGTTTAGCCAGAGTGAAGAAGTTGTCTTCTCCTGATAATGTAAATTGCCGCGATACCCAAGGCAGACATTCAACACCTTTACATTTA GCAGCTGGTTATAATAATTTAGAAGTTGCAGAGTATTTGTTACAACACGGAGCTGATGTGAATGCCCAAGACAAAGGAGGACTTATTCCT TTACATAATGCAGCATCTTACGGGCATGTAGATGTAGCAGCTCTACTAATAAAGTATAATGCATGTGTCAATGCCACGGACAAATGGGCT TTCACACCTTTGCACGAAGCAGCCCAAAAGGGACGAACACAGCTTTGTGCTTTGTTGCTAGCCCATGGAGCTGACCCGACTCTTAAAAAT CAGGAAGGACAAACACCTTTAGATTTAGTTTCAGCGGATGATGTCAGCGCTCTTCTGACAGCAGCCATGCCCCCATCTGCTCTGCCCTCT TGTTACAAGCCTCAAGTGCTCAATGGTGTGAGAAGCCCAGGAGCCACTGCAGATGCTCTCTCTTCAGGTCCATCTAGCCCATCAAGCCTT TCTGCAGCCAGCAGTCTTGACAACTTATCTGGGAGTTTTTCAGAACTGTCTTCAGTAGTTAGTTCAAGTGGAACAGAGGGTGCTTCCAGT TTGGAGAAAAAGGAGGTTCCAGGAGTAGATTTTAGCATAACTCAATTCGTAAGGAATCTTGGACTTGAGCACCTAATGGATATATTTGAG AGAGAACAGATCACTTTGGATGTATTAGTTGAGATGGGGCACAAGGAGCTGAAGGAGATTGGAATCAATGCTTATGGACATAGGCACAAA CTAATTAAAGGAGTCGAGAGACTTATCTCCGGACAACAAGGTCTTAACCCATATTTAACTTTGAACACCTCTGGTAGTGGAACAATTCTT ATAGATCTGTCTCCTGATGATAAAGAGTTTCAGTCTGTGGAGGAAGAGATGCAAAGTACAGTTCGAGAGCACAGAGATGGAGGTCATGCA GGTGGAATCTTCAACAGATACAATATTCTCAAGATTCAGAAGGTTTGTAACAAGAAACTATGGGAAAGATACACTCACCGGAGAAAAGAA GTTTCTGAAGAAAACCACAACCATGCCAATGAACGAATGCTATTTCATGGGTCTCCTTTTGTGAATGCAATTATCCACAAAGGCTTTGAT GAAAGGCATGCGTACATAGGTGGTATGTTTGGAGCTGGCATTTATTTTGCTGAAAACTCTTCCAAAAGCAATCAATATGTATATGGAATT GGAGGAGGTACTGGGTGTCCAGTTCACAAAGACAGATCTTGTTACATTTGCCACAGGCAGCTGCTCTTTTGCCGGGTAACCTTGGGAAAG TCTTTCCTGCAGTTCAGTGCAATGAAAATGGCACATTCTCCTCCAGGTCATCACTCAGTCACTGGTAGGCCCAGTGTAAATGGCCTAGCA TTAGCTGAATATGTTATTTACAGAGGAGAACAGGCTTATCCTGAGTATTTAATTACTTACCAGATTATGAGGCCTGAAGGTATGGTCGAT GGATAAATAGTTATTTTAAGAAACTAATTCCACTGAACCTAAAATCATCAAAGCAGCAGTGGCCTCTACGTTTTACTCCTTTGCTGAAAA AAAATCATCTTGCCCACAGGCCTGTGGCAAAAGGATAAAAATGTGAACGAAGTTTAACATTCTGACTTGATAAAGCTTTAATAATGTACA GTGTTTTCTAAATATTTCCTGTTTTTTCAGCACTTTAACAGATGCCATTCCAGGTTAAACTGGGTTGTCTGTACTAAATTATAAACAGAG TTAACTTGAACCTTTTATATGTTATGCATTGATTCTAACAAACTGTAATGCCCTCAACAGAACTAATTTTACTAATACAATACTGTGTTC TTTAAAACACAGCATTTACACTGAATACAATTTCATTTGTAAAACTGTAAATAAGAGCTTTTGTACTAGCCCAGTATTTATTTACATTGC TTTGTAATATAAATCTGTTTTAGAACTGCAGCGGTTTACAAAATTTTTTCATATGTATTGTTCATCTATACTTCATCTTACATCGTCATG ATTGAGTGATCTTTACATTTGATTCCAGAGGCTATGTTCAGTTGTTAGTTGGGAAAGATTGAGTTATCAGATTTAATTTGCCGATGGGAG CCTTTATCTGTCATTAGAAATCTTTCTCATTTAAGAACTTATGAATATGCTGAAGATTTAATTTGTGATACCTTTGTATGTATGAGACAC ATTCCAAAGAGCTCTAACTATGATAGGTCCTGATTACTAAAGAAGCTTCTTTACTGGCCTCAATTTCTAGCTTTCATGTTGGAAAATTTT CTGCAGTCCTTCTGTGAAAATTAGAGCAAAGTGCTCCTGTTTTTTAGAGAAACTAAATCTTGCTGTTGAACAATTATTGTGTTCTTTTCA TGGAACATAAGTAGGATGTTACATTTCCAGGGTGGGAAGGGTAATCCTAAATCATTTCCCAATCTATTCTAATTACCTTAAATCTAAAGG GGAAAAAAAAAATCACAAACAGGACTGGGTAGTTTTTTATCCTAAGTATATTTTTTCCTGTTCTTTTTACTTGGTTTTATTGCTGTATTT ATAGCCAATCTATACATCATGGGTAAACTTAACCCAGAACTATAAAATGTAGTTGTCTCAGTCCCCTCCAGGCCTCCTGAATGGGCAAGT GCAGTGAAACAGGTGCTTCTTGCTCCTGGGTTTTCTCTCCATGATGTTATGCCCAATTGGAAATATGCTGTCAGTTTGTGCACCATATGG TGACCACGCCTGTGCTCAGTTTGGCAGCTATAGAAGGAAATGCTGTCCCATAAAATGCCATTCCTATTTTCTAATATAAAACTCTTTTCC AGGAAGCATGCTTAAGCATCTTGTTACAGAGACATACATCCATTATGGCTTGGCAATCTCTTTTATTTGTTGACTCTAGCTCCCTTCAAA GTCGAGGAAAGATCTTTACTCACTTAATGAGGACATTCCCCATCACTGTCTGTACCAGTTCACCTTTATTTTACGTTTTATTCAGTCTGT AAATTAACTGGCCCTTTGCAGTAACTTGTACATAAAGTGCTAGAAAATCATGTTCCTTGTCCTGAGTAAGAGTTAATCAGAGTAAATGCA TTTCTGGAGTTGTTTCTGTGATGTAAATTATGATCATTATTTAAGAAGTCAAATCCTGATCTTGAAGTGCTTTTTATACAGCTCTCTAAT AATTACAAATATCCGAAAGTCATTTCTTGGAACACAAGTGGAGTATGCCAAATTTTATATGAATTTTTCAGATTATCTAAGCTTCCAGGT TTTATAATTAGAAGATAATGAGAGAATTAATGGGGTTTATATTTACATTATCTCTCAACTATGTAGCCCATATTACTCACCCTATGAGTG AATCTGGAATTGCTTTTCATGTGAAATCATTGTGGTCTATGAGTTTACAATACTGCAAACTGTGTTATTTTATCTAATCCATTGCTTAAT GAGTGTGTTTTTCCATGAATGAATATACCGTGGTTCATATGTTAGCATGGCAGCATTTTCAGATAGCTTTTTGTTTGTTGGGAAGTTGGG GTTTTGGGGGGAGGGGGAGTATTAGTACGTTGCATGAAATAGCTTACTTTATAATGATGGAATTGCTTTTTCTTTTGTCTTGTGATTTTT TTTTTTGAAGTGAAATTTAACTTTTTGTGCAAGTAGTACTATTATACCCATCTTCAGTGTCTTACTTGTACTGTATCACATTCCATACCC >8336_8336_2_ATRN-TNKS2_ATRN_chr20_3565527_ENST00000446916_TNKS2_chr10_93572740_ENST00000371627_length(amino acids)=2161AA_BP=1486 MVAAAAATEARLRRRTAATAALAGRSGGPHWDWDVTRAGRPGLGAGLRLPRLLSPPLRPRLLLLLLLLSPPLLLLLLPCEAEAAAAAAAV SGSAAAEAKECDRPCVNGGRCNPGTGQCVCPAGWVGEQCQHCGGRFRLTGSSGFVTDGPGNYKYKTKCTWLIEGQPNRIMRLRFNHFATE CSWDHLYVYDGDSIYAPLVAAFSGLIVPERDGNETVPEVVATSGYALLHFFSDAAYNLTGFNITYSFDMCPNNCSGRGECKISNSSDTVE CECSENWKGEACDIPHCTDNCGFPHRGICNSSDVRGCSCFSDWQGPGCSVPVPANQSFWTREEYSNLKLPRASHKAVVNGNIMWVVGGYM FNHSDYNMVLAYDLASREWLPLNRSVNNVVVRYGHSLALYKDKIYMYGGKIDSTGNVTNELRVFHIHNESWVLLTPKAKEQYAVVGHSAH IVTLKNGRVVMLVIFGHCPLYGYISNVQEYDLDKNTWSILHTQGALVQGGYGHSSVYDHRTRALYVHGGYKAFSANKYRLADDLYRYDVD TQMWTILKDSRFFRYLHTAVIVSGTMLVFGGNTHNDTSMSHGAKCFSSDFMAYDIACDRWSVLPRPDLHHDVNRFGHSAVLHNSTMYVFG GFNSLLLSDILVFTSEQCDAHRSEAACLAAGPGIRCVWNTGSSQCISWALATDEQEEKLKSECFSKRTLDHDRCDQHTDCYSCTANTNDC HWCNDHCVPRNHSCSEGQISIFRYENCPKDNPMYYCNKKTSCRSCALDQNCQWEPRNQECIALPENICGIGWHLVGNSCLKITTAKENYD NAKLFCRNHNALLASLTTQKKVEFVLKQLRIMQSSQSMSKLTLTPWVGLRKINVSYWCWEDMSPFTNSLLQWMPSEPSDAGFCGILSEPS TRGLKAATCINPLNGSVCERPANHSAKQCRTPCALRTACGDCTSGSSECMWCSNMKQCVDSNAYVASFPFGQCMEWYTMSTCPPENCSGY CTCSHCLEQPGCGWCTDPSNTGKGKCIEGSYKGPVKMPSQAPTGNFYPQPLLNSSMCLEDSRYNWSFIHCPGFGRKDVVEYLLQNGANVQ ARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGE YKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEM VNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGH LQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAG YNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDG NTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIP LHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSALPS CYKPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSSGTEGASSLEKKEVPGVDFSITQFVRNLGLEHLMDIFE REQITLDVLVEMGHKELKEIGINAYGHRHKLIKGVERLISGQQGLNPYLTLNTSGSGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHA GGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGI GGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPEGMVD -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ATRN-TNKS2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ATRN-TNKS2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ATRN-TNKS2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ATRN | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | ATRN | C0027746 | Nerve Degeneration | 1 | CTD_human |
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