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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SMARCA5-LRBA (FusionGDB2 ID:HG8467TG987)

Fusion Gene Summary for SMARCA5-LRBA

check button Fusion gene summary
Fusion gene informationFusion gene name: SMARCA5-LRBA
Fusion gene ID: hg8467tg987
HgeneTgene
Gene symbol

SMARCA5

LRBA

Gene ID

8467

987

Gene nameSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5LPS responsive beige-like anchor protein
SynonymsISWI|SNF2H|WCRF135|hISWI|hSNF2HBGL|CDC4L|CVID8|LAB300|LBA
Cytomap('SMARCA5')('LRBA')

4q31.21

4q31.3

Type of geneprotein-codingprotein-coding
DescriptionSWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5sucrose nonfermenting protein 2 homologsucrose nonfermenting-like 5lipopolysaccharide-responsive and beige-like anchor proteinCDC4-like proteinLPS-responsive vesicle trafficking, beach and anchor containingvesicle trafficking, beach and anchor containing
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000283131, 
Fusion gene scores* DoF score2 X 2 X 2=825 X 25 X 10=6250
# samples 227
** MAII scorelog2(2/8*10)=1.32192809488736log2(27/6250*10)=-4.53282487738598
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SMARCA5 [Title/Abstract] AND LRBA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSMARCA5(144469293)-LRBA(151358016), # samples:3
Anticipated loss of major functional domain due to fusion event.SMARCA5-LRBA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SMARCA5-LRBA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SMARCA5-LRBA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SMARCA5-LRBA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSMARCA5

GO:0006334

nucleosome assembly

12972596

HgeneSMARCA5

GO:0006338

chromatin remodeling

9836642

HgeneSMARCA5

GO:0006352

DNA-templated transcription, initiation

9836642

HgeneSMARCA5

GO:0016584

nucleosome positioning

9836642


check buttonFusion gene breakpoints across SMARCA5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across LRBA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-FD-A3B7-01ASMARCA5chr4

144469293

+LRBAchr4

151358016

-
ChimerDB4BLCATCGA-FD-A3B7SMARCA5chr4

144469293

+LRBAchr4

151358016

-


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Fusion Gene ORF analysis for SMARCA5-LRBA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000283131ENST00000357115SMARCA5chr4

144469293

+LRBAchr4

151358016

-
5CDS-5UTRENST00000283131ENST00000503716SMARCA5chr4

144469293

+LRBAchr4

151358016

-
5CDS-5UTRENST00000283131ENST00000507224SMARCA5chr4

144469293

+LRBAchr4

151358016

-
In-frameENST00000283131ENST00000510413SMARCA5chr4

144469293

+LRBAchr4

151358016

-
In-frameENST00000283131ENST00000535741SMARCA5chr4

144469293

+LRBAchr4

151358016

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000283131SMARCA5chr4144469293+ENST00000535741LRBAchr4151358016-6506344746252251587
ENST00000283131SMARCA5chr4144469293+ENST00000510413LRBAchr4151358016-6414344746252221586

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000283131ENST00000535741SMARCA5chr4144469293+LRBAchr4151358016-0.0007400890.9992599
ENST00000283131ENST00000510413SMARCA5chr4144469293+LRBAchr4151358016-0.0004664250.99953365

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Fusion Genomic Features for SMARCA5-LRBA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for SMARCA5-LRBA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:144469293/chr4:151358016)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMARCA5chr4:144469293chr4:151358016ENST00000283131+22247_139951053.0Compositional biasNote=Poly-Pro
HgeneSMARCA5chr4:144469293chr4:151358016ENST00000283131+2224192_3579951053.0DomainHelicase ATP-binding
HgeneSMARCA5chr4:144469293chr4:151358016ENST00000283131+2224487_6389951053.0DomainHelicase C-terminal
HgeneSMARCA5chr4:144469293chr4:151358016ENST00000283131+2224840_8929951053.0DomainSANT 1
HgeneSMARCA5chr4:144469293chr4:151358016ENST00000283131+2224308_3119951053.0MotifNote=DEAH box
HgeneSMARCA5chr4:144469293chr4:151358016ENST00000283131+2224205_2129951053.0Nucleotide bindingATP
TgeneLRBAchr4:144469293chr4:151358016ENST0000035711544582591_263322712864.0RepeatNote=WD 2
TgeneLRBAchr4:144469293chr4:151358016ENST0000035711544582636_267922712864.0RepeatNote=WD 3
TgeneLRBAchr4:144469293chr4:151358016ENST0000035711544582695_273522712864.0RepeatNote=WD 4
TgeneLRBAchr4:144469293chr4:151358016ENST0000035711544582777_281622712864.0RepeatNote=WD 5
TgeneLRBAchr4:144469293chr4:151358016ENST0000035711544582819_285822712864.0RepeatNote=WD 6
TgeneLRBAchr4:144469293chr4:151358016ENST0000051041343572591_263322602852.0RepeatNote=WD 2
TgeneLRBAchr4:144469293chr4:151358016ENST0000051041343572636_267922602852.0RepeatNote=WD 3
TgeneLRBAchr4:144469293chr4:151358016ENST0000051041343572695_273522602852.0RepeatNote=WD 4
TgeneLRBAchr4:144469293chr4:151358016ENST0000051041343572777_281622602852.0RepeatNote=WD 5
TgeneLRBAchr4:144469293chr4:151358016ENST0000051041343572819_285822602852.0RepeatNote=WD 6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMARCA5chr4:144469293chr4:151358016ENST00000283131+2224943_10079951053.0DomainSANT 2
TgeneLRBAchr4:144469293chr4:151358016ENST0000035711544581006_105322712864.0Coiled coilOntology_term=ECO:0000255
TgeneLRBAchr4:144469293chr4:151358016ENST0000051041343571006_105322602852.0Coiled coilOntology_term=ECO:0000255
TgeneLRBAchr4:144469293chr4:151358016ENST0000035711544581990_199422712864.0Compositional biasNote=Poly-Arg
TgeneLRBAchr4:144469293chr4:151358016ENST0000051041343571990_199422602852.0Compositional biasNote=Poly-Arg
TgeneLRBAchr4:144469293chr4:151358016ENST0000035711544582073_218122712864.0DomainBEACH-type PH
TgeneLRBAchr4:144469293chr4:151358016ENST0000035711544582200_248922712864.0DomainBEACH
TgeneLRBAchr4:144469293chr4:151358016ENST0000051041343572073_218122602852.0DomainBEACH-type PH
TgeneLRBAchr4:144469293chr4:151358016ENST0000051041343572200_248922602852.0DomainBEACH
TgeneLRBAchr4:144469293chr4:151358016ENST0000035711544581301_134322712864.0RepeatNote=WD 1
TgeneLRBAchr4:144469293chr4:151358016ENST0000051041343571301_134322602852.0RepeatNote=WD 1
TgeneLRBAchr4:144469293chr4:151358016ENST0000035711544581531_154822712864.0TransmembraneHelical
TgeneLRBAchr4:144469293chr4:151358016ENST0000051041343571531_154822602852.0TransmembraneHelical


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Fusion Gene Sequence for SMARCA5-LRBA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>83915_83915_1_SMARCA5-LRBA_SMARCA5_chr4_144469293_ENST00000283131_LRBA_chr4_151358016_ENST00000510413_length(transcript)=6414nt_BP=3447nt
GCGAGTGTTGAAAGTCGGTGGCGTAGGTCGTCGTCCTGGATGCTGGCGAGATAGATGTTATCTTCCAGAGGAAGAGGAGGAGGCGGCGAA
GCGTTTTCCCAGCCTCAGTCTCTCTTTCGTTTTCCTTTTCCCTTCCCCCAACCCTCCGCCCTTCTCTAAATCAGCCGGCCTTCCTTGACC
TCAGTGACCCGTCTGGCCCCGCCCACCCTCGTCGACGTGATTCCCGCCGTGAGGTAAGCGCCGGTGGAACCTAGAGCCCCGCGGAAGAGC
AGAACGTTTGGGAGTGTGCAGCTCCTGGGCCCGGCTCAGGCCCGTCGCGGAGGCGCGGCGCAGGGGAGCGCTCGGGTGGGAGTCTCGCTC
CTCCACCAGTTTATTGCGACGTAGCATCCAGGCCTAGGCCTCCCCGTCCATCCCCGCCGGACTCGGGCCTCTGGCAGCAGCGGGTGACGC
AGACGGAACATCATGTCGTCCGCGGCCGAGCCTCCGCCACCCCCGCCTCCCGAGAGCGCGCCTTCCAAGCCCGCAGCCTCGATCGCCAGC
GGCGGGAGCAACAGCAGCAACAAAGGCGGCCCCGAAGGCGTCGCGGCGCAGGCGGTTGCGTCTGCGGCCAGCGCTGGTCCCGCAGACGCC
GAGATGGAGGAAATATTTGATGATGCGTCACCTGGAAAGCAAAAGGAAATCCAAGAACCAGATCCTACCTATGAAGAAAAAATGCAAACT
GACCGGGCAAATAGATTCGAGTATTTATTAAAGCAGACAGAACTTTTTGCACATTTCATTCAACCTGCTGCTCAGAAGACTCCAACTTCA
CCTTTGAAGATGAAACCAGGGCGCCCACGAATAAAAAAAGATGAGAAGCAGAACTTACTATCCGTTGGCGATTACCGACACCGTAGAACA
GAGCAAGAGGAGGATGAAGAGCTATTAACAGAAAGCTCCAAAGCAACCAATGTTTGCACTCGATTTGAAGACTCTCCATCGTATGTAAAA
TGGGGTAAACTGAGAGATTATCAGGTCCGAGGATTAAACTGGCTCATTTCTTTGTATGAGAATGGCATCAATGGTATCCTTGCAGATGAA
ATGGGCCTAGGAAAGACTCTTCAAACAATTTCTCTTCTTGGGTACATGAAACATTATAGAAACATTCCTGGGCCTCATATGGTTTTGGTT
CCTAAGTCTACATTACACAACTGGATGAGTGAATTCAAGAGATGGGTACCAACACTTAGATCTGTTTGTTTGATAGGAGATAAAGAACAA
AGAGCTGCTTTTGTCAGAGACGTTTTATTACCGGGAGAATGGGATGTATGTGTAACATCTTATGAAATGCTTATTAAAGAGAAGTCTGTG
TTCAAAAAATTTAATTGGAGATACTTAGTAATAGATGAAGCTCACAGGATCAAAAATGAAAAATCTAAGTTGTCAGAAATAGTGAGGGAA
TTCAAGACTACAAATAGACTATTATTAACTGGAACACCTCTTCAGAACAACTTGCATGAGCTGTGGTCACTTCTTAACTTTCTGTTGCCA
GATGTGTTTAATTCAGCAGATGACTTTGATTCCTGGTTTGATACAAACAACTGCCTTGGGGATCAAAAACTAGTTGAGAGGCTTCATATG
GTTTTGCGTCCATTCCTCCTTCGTCGAATTAAGGCTGATGTTGAAAAGAGTTTGCCTCCAAAGAAGGAAGTAAAAATCTATGTGGGCCTC
AGCAAAATGCAAAGGGAATGGTATACTCGGATATTAATGAAGGATATAGATATACTCAACTCAGCAGGCAAGATGGACAAAATGAGGTTA
TTGAACATCCTAATGCAGTTGAGAAAATGTTGTAATCATCCATATCTCTTTGATGGAGCAGAACCTGGTCCACCTTATACAACAGATATG
CATCTAGTAACCAACAGTGGCAAAATGGTGGTTTTAGACAAGCTGCTCCCTAAGTTAAAAGAACAAGGTTCACGAGTACTAATCTTCAGT
CAAATGACAAGGGTATTGGACATTTTGGAAGATTATTGCATGTGGAGAAATTATGAGTACTGCAGGTTGGATGGTCAGACACCCCATGAT
GAGAGACAAGACTCCATCAATGCATACAATGAACCAAACAGCACAAAGTTTGTTTTCATGTTAAGCACGCGTGCTGGTGGTCTTGGCATC
AATCTTGCGACTGCTGATGTAGTAATTTTGTATGATTCTGATTGGAATCCCCAAGTAGATCTTCAGGCTATGGACCGAGCACATAGAATT
GGGCAGACTAAGACAGTCAGAGTGTTCCGCTTTATAACTGATAACACTGTAGAAGAAAGAATAGTAGAACGTGCTGAGATGAAACTCAGA
CTGGATTCAATAGTCATTCAACAAGGGAGGCTTGTGGATCAGAATCTGAACAAAATTGGGAAAGATGAAATGCTTCAAATGATTAGACAT
GGAGCAACACATGTGTTTGCTTCAAAGGAAAGTGAGATCACTGATGAAGATATCGATGGTATTTTGGAAAGAGGTGCAAAGAAGACTGCA
GAGATGAATGAAAAGCTCTCCAAGATGGGCGAAAGTTCACTTAGAAACTTTACAATGGATACAGAGTCAAGTGTTTATAACTTCGAAGGA
GAAGACTATAGAGAAAAACAAAAGATTGCATTCACAGAGTGGATTGAACCACCTAAACGAGAAAGAAAAGCCAACTATGCCGTTGATGCA
TATTTCAGGGAAGCTCTTCGTGTTAGTGAACCTAAAGCACCCAAGGCTCCTCGACCTCCAAAACAACCCAATGTTCAGGATTTCCAGTTC
TTTCCTCCACGTTTATTTGAATTACTGGAAAAAGAAATTCTGTTTTACAGAAAAACTATTGGGTACAAGGTACCTCGAAATCCTGAGCTG
CCTAATGCAGCACAGGCACAAAAAGAAGAACAGCTTAAAATTGATGAAGCTGAATCCCTTAATGATGAAGAGTTAGAGGAAAAAGAGAAG
CTTCTAACACAGGGATTTACCAATTGGAATAAGAGAGATTTTAACCAGTTTATCAAAGCTAATGAGAAGTGGGGTCGTGATGATATTGAA
AATATAGCAAGAGAAGTAGAAGGCAAAACTCCAGAAGAAGTCATTGAATATTCAGCTGTGTTTTGGGAAAGGTGCAACGAGCTCCAGGAC
ATAGAGAAGATTATGGCTCAGATTGAAAGGGGAGAGGCGAGAATTCAAAGAAGAATAAGCATCAAGAAAGCACTTGACACAAAGATTGGA
CGGTACAAAGCACCTTTTCATCAGCTGAGAATATCATATGGTACTAACAAAGGAAAAAACTATACTGAAGAAGAAGATCGTTTTCTGATT
TGTATGCTTCACAAACTTGGATTTGACAAAGAAAATGTTTATGATGAATTGCGACAGTGTATTCGCAACTCTCCTCAGTTCAGATTTGAC
TGGTTTCTTAAGTCCAGAACTGCAATGCCAATAGGAGCTCTGAACCCAAAAAGAGCAGCATTCTTCGCTGAGCGTTATGAATCATGGGAA
GATGATCAAGTTCCAAAGTTTCACTATGGTACTCATTACTCAACTGCAAGTTTTGTTCTTGCATGGCTGCTAAGAATAGAACCCTTTACA
ACTTATTTCCTAAATTTGCAAGGAGGCAAATTTGATCATGCAGATCGAACTTTTTCATCAATTTCCAGAGCTTGGCGAAACAGTCAGCGT
GATACCTCTGATATTAAGGAGTTGATCCCTGAATTTTATTATCTCCCTGAGATGTTTGTCAACTTCAATAATTATAATCTTGGAGTGATG
GATGATGGGACAGTAGTGTCTGATGTCGAACTTCCTCCTTGGGCCAAAACCTCAGAAGAATTTGTTCACATAAACAGATTGGCCCTGGAG
AGTGAATTTGTTTCCTGCCAGCTTCACCAATGGATTGATCTCATTTTTGGCTATAAACAGCAAGGACCAGAAGCTGTCCGAGCCCTCAAT
GTGTTCTATTACTTGACCTATGAAGGAGCTGTCAATCTGAATTCAATAACTGATCCTGTGTTGAGAGAGGCTGTTGAAGCTCAAATCCGA
AGTTTTGGACAGACTCCTTCTCAACTACTCATAGAGCCCCATCCTCCCAGAGGTTCTGCCATGCAAGTGAGTCCATTGATGTTCACAGAC
AAAGCCCAGCAGGATGTTATCATGGTCCTCAAGTTTCCCTCCAACTCCCCTGTTACTCACGTGGCAGCCAACACCCAGCCTGGTTTGGCA
ACTCCCGCTGTGATCACAGTCACTGCTAACAGGTTATTTGCGGTGAACAAATGGCACAACCTTCCTGCTCATCAAGGTGCTGTACAAGAC
CAGCCATACCAGCTGCCAGTGGAAATCGATCCTCTCATAGCCAGCAATACAGGAATGCACAGGAGGCAAATCACTGACCTTTTAGACCAA
AGTATTCAAGTGCATTCCCAGTGCTTTGTCATCACTTCAGACAACCGCTATATTCTCGTCTGTGGCTTCTGGGATAAAAGTTTCAGAGTC
TATTCTACAGACACAGGAAGATTGATCCAAGTGGTGTTTGGCCATTGGGATGTCGTCACTTGCCTTGCTCGTTCTGAGTCATATATTGGG
GGAAATTGCTACATTCTCTCAGGGTCACGTGATGCAACTCTTTTGCTGTGGTATTGGAATGGAAAATGCAGTGGGATTGGAGATAACCCA
GGTGAGACTGCTGCTCCTCGGGCCATTTTGACCGGCCATGACTATGAGGTCACATGTGCTGCGGTGTGTGCGGAGCTAGGCCTGGTGTTG
AGTGGTTCACAAGAAGGACCATGTCTCATACATTCCATGAATGGAGACTTGTTGAGGACCTTGGAGGGTCCTGAAAACTGCCTGAAACCA
AAACTCATTCAGGCTTCAAGAGAGGGTCATTGTGTCATATTCTATGAAAACGGCCTCTTCTGTACATTCAGTGTGAATGGAAAACTCCAG
GCCACGATGGAAACAGATGATAACATAAGAGCCATCCAGCTGAGCCGAGATGGGCAGTACCTGCTCACAGGAGGAGACAGAGGAGTGGTC
GTGGTCCGGCAGGTGTCGGACCTCAAGCAGCTCTTTGCCTATCCAGGATGTGACGCTGGAATCCGGGCCATGGCGCTGTCTTACGACCAG
AGGTGCATCATTTCTGGCATGGCTTCAGGAAGCATTGTGCTATTTTACAACGACTTTAACCGGTGGCATCATGAATACCAAACCCGCTAC
TGATGGTGACAGCTGTACATCAACTCTGCCCCTAGGATGAGCAGAAGTACCTGGAGCATCATTCTCTTCTACCACATCTGAATGTAACTT
AAATTTGCTCAAAGAAGCAAAATATTTTTTAAAGTTATTAATAATTGCTATTTTTGTAGTCTTTGCTTGACTTTTTTGGGGGGGATTAGC
AAAGCAGAAAACTGGCTGCTGGGTTCTGTAGTTTTAAAAAATCTATATTTTTAGTCATAATGAGAAGTCTATTTTCACCAATTATGGAAA
CATACAGTGGAGCAAGTAAACCACTTATTCCAGCTATAATATTATGAAGAACATTTCCCATGCATCTACAAGCTTGAGAAATAGGATTTT
CACAGTGGGGAAGTGGGTTACAATATTGGAATAGGAAAATTTGATGCTGTAATTTGGGTCCTGTATTTTTCCAAACAACTGTGCTTCTTC
AGCACTAATATTTCTGGGATTTAAATAGTAATGTTTAAATTATGGTAAATGTAATTTAAAACATCTCAATTAAGTCTGTCTATCAATATT
GTTCTTCAAGCATGTTTTAGACCTAGAAAAGTATGGTTTGGGGGAGGCTATTTTATTGTGTGGTTAGCACAAGGAATCTAATTTATAGCA
AGTGTGAAATAGTTACCATTTTTTCCTGATCTGTCATCTTCATAGCACAACAAAACGAAATGATGGAAATGCTCTTGAGCTCACAACATT
TGTTTTTCTTTTAAAGTAAATGCAAGTACCAAAGCTCACTACTGCGGTTTGCCTGTGCCTGGACAATGAGGCGGAGCCACTGTTGTTTTG
TTGGGGCACCCCCTTCCCTCCCCGGGTTTGCAAATAGAGGCTACCGGGTGCTGTATTCAGCAACACCTGTTTTACTATTTGTTATTAAAC
TATCATCTCCACCTTCCTTTTGATTAGCAATTTGTACTAAGAAACGAAACAATGTTATTTGGTGGTGTATAATTCTACTTTTCTAGTAGA
TTACTGTGTGGAATTCTGTGAAAAATATTTGAGAAAAGGCCTGTATTGCATAAATAAATTCTTTGTATGTTGTGAACTTTGATCTCTATT
TCTCTTGCAACAGACTTCAAGTGGTCCCTCTTTTTTTCCTACACACTCAGCTCTTCTCTAAAAGCAAGGATTTGGAATGAACAATTCAGT

>83915_83915_1_SMARCA5-LRBA_SMARCA5_chr4_144469293_ENST00000283131_LRBA_chr4_151358016_ENST00000510413_length(amino acids)=1586AA_BP=995
MSSAAEPPPPPPPESAPSKPAASIASGGSNSSNKGGPEGVAAQAVASAASAGPADAEMEEIFDDASPGKQKEIQEPDPTYEEKMQTDRAN
RFEYLLKQTELFAHFIQPAAQKTPTSPLKMKPGRPRIKKDEKQNLLSVGDYRHRRTEQEEDEELLTESSKATNVCTRFEDSPSYVKWGKL
RDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRNIPGPHMVLVPKSTLHNWMSEFKRWVPTLRSVCLIGDKEQRAAF
VRDVLLPGEWDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWSLLNFLLPDVFN
SADDFDSWFDTNNCLGDQKLVERLHMVLRPFLLRRIKADVEKSLPPKKEVKIYVGLSKMQREWYTRILMKDIDILNSAGKMDKMRLLNIL
MQLRKCCNHPYLFDGAEPGPPYTTDMHLVTNSGKMVVLDKLLPKLKEQGSRVLIFSQMTRVLDILEDYCMWRNYEYCRLDGQTPHDERQD
SINAYNEPNSTKFVFMLSTRAGGLGINLATADVVILYDSDWNPQVDLQAMDRAHRIGQTKTVRVFRFITDNTVEERIVERAEMKLRLDSI
VIQQGRLVDQNLNKIGKDEMLQMIRHGATHVFASKESEITDEDIDGILERGAKKTAEMNEKLSKMGESSLRNFTMDTESSVYNFEGEDYR
EKQKIAFTEWIEPPKRERKANYAVDAYFREALRVSEPKAPKAPRPPKQPNVQDFQFFPPRLFELLEKEILFYRKTIGYKVPRNPELPNAA
QAQKEEQLKIDEAESLNDEELEEKEKLLTQGFTNWNKRDFNQFIKANEKWGRDDIENIAREVEGKTPEEVIEYSAVFWERCNELQDIEKI
MAQIERGEARIQRRISIKKALDTKIGRYKAPFHQLRISYGTNKGKNYTEEEDRFLICMLHKLGFDKENVYDELRQCIRNSPQFRFDWFLK
SRTAMPIGALNPKRAAFFAERYESWEDDQVPKFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSISRAWRNSQRDTSD
IKELIPEFYYLPEMFVNFNNYNLGVMDDGTVVSDVELPPWAKTSEEFVHINRLALESEFVSCQLHQWIDLIFGYKQQGPEAVRALNVFYY
LTYEGAVNLNSITDPVLREAVEAQIRSFGQTPSQLLIEPHPPRGSAMQVSPLMFTDKAQQDVIMVLKFPSNSPVTHVAANTQPGLATPAV
ITVTANRLFAVNKWHNLPAHQGAVQDQPYQLPVEIDPLIASNTGMHRRQITDLLDQSIQVHSQCFVITSDNRYILVCGFWDKSFRVYSTD
TGRLIQVVFGHWDVVTCLARSESYIGGNCYILSGSRDATLLLWYWNGKCSGIGDNPGETAAPRAILTGHDYEVTCAAVCAELGLVLSGSQ
EGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATMETDDNIRAIQLSRDGQYLLTGGDRGVVVVRQ

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>83915_83915_2_SMARCA5-LRBA_SMARCA5_chr4_144469293_ENST00000283131_LRBA_chr4_151358016_ENST00000535741_length(transcript)=6506nt_BP=3447nt
GCGAGTGTTGAAAGTCGGTGGCGTAGGTCGTCGTCCTGGATGCTGGCGAGATAGATGTTATCTTCCAGAGGAAGAGGAGGAGGCGGCGAA
GCGTTTTCCCAGCCTCAGTCTCTCTTTCGTTTTCCTTTTCCCTTCCCCCAACCCTCCGCCCTTCTCTAAATCAGCCGGCCTTCCTTGACC
TCAGTGACCCGTCTGGCCCCGCCCACCCTCGTCGACGTGATTCCCGCCGTGAGGTAAGCGCCGGTGGAACCTAGAGCCCCGCGGAAGAGC
AGAACGTTTGGGAGTGTGCAGCTCCTGGGCCCGGCTCAGGCCCGTCGCGGAGGCGCGGCGCAGGGGAGCGCTCGGGTGGGAGTCTCGCTC
CTCCACCAGTTTATTGCGACGTAGCATCCAGGCCTAGGCCTCCCCGTCCATCCCCGCCGGACTCGGGCCTCTGGCAGCAGCGGGTGACGC
AGACGGAACATCATGTCGTCCGCGGCCGAGCCTCCGCCACCCCCGCCTCCCGAGAGCGCGCCTTCCAAGCCCGCAGCCTCGATCGCCAGC
GGCGGGAGCAACAGCAGCAACAAAGGCGGCCCCGAAGGCGTCGCGGCGCAGGCGGTTGCGTCTGCGGCCAGCGCTGGTCCCGCAGACGCC
GAGATGGAGGAAATATTTGATGATGCGTCACCTGGAAAGCAAAAGGAAATCCAAGAACCAGATCCTACCTATGAAGAAAAAATGCAAACT
GACCGGGCAAATAGATTCGAGTATTTATTAAAGCAGACAGAACTTTTTGCACATTTCATTCAACCTGCTGCTCAGAAGACTCCAACTTCA
CCTTTGAAGATGAAACCAGGGCGCCCACGAATAAAAAAAGATGAGAAGCAGAACTTACTATCCGTTGGCGATTACCGACACCGTAGAACA
GAGCAAGAGGAGGATGAAGAGCTATTAACAGAAAGCTCCAAAGCAACCAATGTTTGCACTCGATTTGAAGACTCTCCATCGTATGTAAAA
TGGGGTAAACTGAGAGATTATCAGGTCCGAGGATTAAACTGGCTCATTTCTTTGTATGAGAATGGCATCAATGGTATCCTTGCAGATGAA
ATGGGCCTAGGAAAGACTCTTCAAACAATTTCTCTTCTTGGGTACATGAAACATTATAGAAACATTCCTGGGCCTCATATGGTTTTGGTT
CCTAAGTCTACATTACACAACTGGATGAGTGAATTCAAGAGATGGGTACCAACACTTAGATCTGTTTGTTTGATAGGAGATAAAGAACAA
AGAGCTGCTTTTGTCAGAGACGTTTTATTACCGGGAGAATGGGATGTATGTGTAACATCTTATGAAATGCTTATTAAAGAGAAGTCTGTG
TTCAAAAAATTTAATTGGAGATACTTAGTAATAGATGAAGCTCACAGGATCAAAAATGAAAAATCTAAGTTGTCAGAAATAGTGAGGGAA
TTCAAGACTACAAATAGACTATTATTAACTGGAACACCTCTTCAGAACAACTTGCATGAGCTGTGGTCACTTCTTAACTTTCTGTTGCCA
GATGTGTTTAATTCAGCAGATGACTTTGATTCCTGGTTTGATACAAACAACTGCCTTGGGGATCAAAAACTAGTTGAGAGGCTTCATATG
GTTTTGCGTCCATTCCTCCTTCGTCGAATTAAGGCTGATGTTGAAAAGAGTTTGCCTCCAAAGAAGGAAGTAAAAATCTATGTGGGCCTC
AGCAAAATGCAAAGGGAATGGTATACTCGGATATTAATGAAGGATATAGATATACTCAACTCAGCAGGCAAGATGGACAAAATGAGGTTA
TTGAACATCCTAATGCAGTTGAGAAAATGTTGTAATCATCCATATCTCTTTGATGGAGCAGAACCTGGTCCACCTTATACAACAGATATG
CATCTAGTAACCAACAGTGGCAAAATGGTGGTTTTAGACAAGCTGCTCCCTAAGTTAAAAGAACAAGGTTCACGAGTACTAATCTTCAGT
CAAATGACAAGGGTATTGGACATTTTGGAAGATTATTGCATGTGGAGAAATTATGAGTACTGCAGGTTGGATGGTCAGACACCCCATGAT
GAGAGACAAGACTCCATCAATGCATACAATGAACCAAACAGCACAAAGTTTGTTTTCATGTTAAGCACGCGTGCTGGTGGTCTTGGCATC
AATCTTGCGACTGCTGATGTAGTAATTTTGTATGATTCTGATTGGAATCCCCAAGTAGATCTTCAGGCTATGGACCGAGCACATAGAATT
GGGCAGACTAAGACAGTCAGAGTGTTCCGCTTTATAACTGATAACACTGTAGAAGAAAGAATAGTAGAACGTGCTGAGATGAAACTCAGA
CTGGATTCAATAGTCATTCAACAAGGGAGGCTTGTGGATCAGAATCTGAACAAAATTGGGAAAGATGAAATGCTTCAAATGATTAGACAT
GGAGCAACACATGTGTTTGCTTCAAAGGAAAGTGAGATCACTGATGAAGATATCGATGGTATTTTGGAAAGAGGTGCAAAGAAGACTGCA
GAGATGAATGAAAAGCTCTCCAAGATGGGCGAAAGTTCACTTAGAAACTTTACAATGGATACAGAGTCAAGTGTTTATAACTTCGAAGGA
GAAGACTATAGAGAAAAACAAAAGATTGCATTCACAGAGTGGATTGAACCACCTAAACGAGAAAGAAAAGCCAACTATGCCGTTGATGCA
TATTTCAGGGAAGCTCTTCGTGTTAGTGAACCTAAAGCACCCAAGGCTCCTCGACCTCCAAAACAACCCAATGTTCAGGATTTCCAGTTC
TTTCCTCCACGTTTATTTGAATTACTGGAAAAAGAAATTCTGTTTTACAGAAAAACTATTGGGTACAAGGTACCTCGAAATCCTGAGCTG
CCTAATGCAGCACAGGCACAAAAAGAAGAACAGCTTAAAATTGATGAAGCTGAATCCCTTAATGATGAAGAGTTAGAGGAAAAAGAGAAG
CTTCTAACACAGGGATTTACCAATTGGAATAAGAGAGATTTTAACCAGTTTATCAAAGCTAATGAGAAGTGGGGTCGTGATGATATTGAA
AATATAGCAAGAGAAGTAGAAGGCAAAACTCCAGAAGAAGTCATTGAATATTCAGCTGTGTTTTGGGAAAGGTGCAACGAGCTCCAGGAC
ATAGAGAAGATTATGGCTCAGATTGAAAGGGGAGAGGCGAGAATTCAAAGAAGAATAAGCATCAAGAAAGCACTTGACACAAAGATTGGA
CGGTACAAAGCACCTTTTCATCAGCTGAGAATATCATATGGTACTAACAAAGGAAAAAACTATACTGAAGAAGAAGATCGTTTTCTGATT
TGTATGCTTCACAAACTTGGATTTGACAAAGAAAATGTTTATGATGAATTGCGACAGTGTATTCGCAACTCTCCTCAGTTCAGATTTGAC
TGGTTTCTTAAGTCCAGAACTGCAATGCCAATAGGAGCTCTGAACCCAAAAAGAGCAGCATTCTTCGCTGAGCGTTATGAATCATGGGAA
GATGATCAAGTTCCAAAGTTTCACTATGGTACTCATTACTCAACTGCAAGTTTTGTTCTTGCATGGCTGCTAAGAATAGAACCCTTTACA
ACTTATTTCCTAAATTTGCAAGGAGGCAAATTTGATCATGCAGATCGAACTTTTTCATCAATTTCCAGAGCTTGGCGAAACAGTCAGCGT
GATACCTCTGATATTAAGGAGTTGATCCCTGAATTTTATTATCTCCCTGAGATGTTTGTCAACTTCAATAATTATAATCTTGGAGTGATG
GATGATGGGACAGTAGTGTCTGATGTCGAACTTCCTCCTTGGGCCAAAACCTCAGAAGAATTTGTTCACATAAACAGATTGGCCCTGGAG
AGTGAATTTGTTTCCTGCCAGCTTCACCAATGGATTGATCTCATTTTTGGCTATAAACAGCAAGGACCAGAAGCTGTCCGAGCCCTCAAT
GTGTTCTATTACTTGACCTATGAAGGAGCTGTCAATCTGAATTCAATAACTGATCCTGTGTTGAGAGAGGCTGTTGAAGCTCAAATCCGA
AGTTTTGGACAGACTCCTTCTCAACTACTCATAGAGCCCCATCCTCCCAGAGGTTCTGCCATGCAAGTGAGTCCATTGATGTTCACAGAC
AAAGCCCAGCAGGATGTTATCATGGTCCTCAAGTTTCCCTCCAACTCCCCTGTTACTCACGTGGCAGCCAACACCCAGCCTGGTTTGGCA
ACTCCCGCTGTGATCACAGTCACTGCTAACAGGTTATTTGCGGTGAACAAATGGCACAACCTTCCTGCTCATCAAGGTGCTGTACAAGAC
CAGCCATACCAGCTGCCAGTGGAAATCGATCCTCTCATAGCCAGCAATACAGGAATGCACAGGAGGCAAATCACTGACCTTTTAGACCAA
AGTATTCAAGTGCATTCCCAGTGCTTTGTCATCACTTCAGACAACCGCTATATTCTCGTCTGTGGCTTCTGGGATAAAAGTTTCAGAGTC
TATTCTACAGACACAGGAAGATTGATCCAAGTGGTGTTTGGCCATTGGGATGTCGTCACTTGCCTTGCTCGTTCTGAGTCATATATTGGG
GGAAATTGCTACATTCTCTCAGGGTCACGTGATGCAACTCTTTTGCTGTGGTATTGGAATGGAAAATGCAGTGGGATTGGAGATAACCCA
GGCAGTGAGACTGCTGCTCCTCGGGCCATTTTGACCGGCCATGACTATGAGGTCACATGTGCTGCGGTGTGTGCGGAGCTAGGCCTGGTG
TTGAGTGGTTCACAAGAAGGACCATGTCTCATACATTCCATGAATGGAGACTTGTTGAGGACCTTGGAGGGTCCTGAAAACTGCCTGAAA
CCAAAACTCATTCAGGCTTCAAGAGAGGGTCATTGTGTCATATTCTATGAAAACGGCCTCTTCTGTACATTCAGTGTGAATGGAAAACTC
CAGGCCACGATGGAAACAGATGATAACATAAGAGCCATCCAGCTGAGCCGAGATGGGCAGTACCTGCTCACAGGAGGAGACAGAGGAGTG
GTCGTGGTCCGGCAGGTGTCGGACCTCAAGCAGCTCTTTGCCTATCCAGGATGTGACGCTGGAATCCGGGCCATGGCGCTGTCTTACGAC
CAGAGGTGCATCATTTCTGGCATGGCTTCAGGAAGCATTGTGCTATTTTACAACGACTTTAACCGGTGGCATCATGAATACCAAACCCGC
TACTGATGGTGACAGCTGTACATCAACTCTGCCCCTAGGATGAGCAGAAGTACCTGGAGCATCATTCTCTTCTACCACATCTGAATGTAA
CTTAAATTTGCTCAAAGAAGCAAAATATTTTTTAAAGTTATTAATAATTGCTATTTTTGTAGTCTTTGCTTGACTTTTTTGGGGGGGATT
AGCAAAGCAGAAAACTGGCTGCTGGGTTCTGTAGTTTTAAAAAATCTATATTTTTAGTCATAATGAGAAGTCTATTTTCACCAATTATGG
AAACATACAGTGGAGCAAGTAAACCACTTATTCCAGCTATAATATTATGAAGAACATTTCCCATGCATCTACAAGCTTGAGAAATAGGAT
TTTCACAGTGGGGAAGTGGGTTACAATATTGGAATAGGAAAATTTGATGCTGTAATTTGGGTCCTGTATTTTTCCAAACAACTGTGCTTC
TTCAGCACTAATATTTCTGGGATTTAAATAGTAATGTTTAAATTATGGTAAATGTAATTTAAAACATCTCAATTAAGTCTGTCTATCAAT
ATTGTTCTTCAAGCATGTTTTAGACCTAGAAAAGTATGGTTTGGGGGAGGCTATTTTATTGTGTGGTTAGCACAAGGAATCTAATTTATA
GCAAGTGTGAAATAGTTACCATTTTTTCCTGATCTGTCATCTTCATAGCACAACAAAACGAAATGATGGAAATGCTCTTGAGCTCACAAC
ATTTGTTTTTCTTTTAAAGTAAATGCAAGTACCAAAGCTCACTACTGCGGTTTGCCTGTGCCTGGACAATGAGGCGGAGCCACTGTTGTT
TTGTTGGGGCACCCCCTTCCCTCCCCGGGTTTGCAAATAGAGGCTACCGGGTGCTGTATTCAGCAACACCTGTTTTACTATTTGTTATTA
AACTATCATCTCCACCTTCCTTTTGATTAGCAATTTGTACTAAGAAACGAAACAATGTTATTTGGTGGTGTATAATTCTACTTTTCTAGT
AGATTACTGTGTGGAATTCTGTGAAAAATATTTGAGAAAAGGCCTGTATTGCATAAATAAATTCTTTGTATGTTGTGAACTTTGATCTCT
ATTTCTCTTGCAACAGACTTCAAGTGGTCCCTCTTTTTTTCCTACACACTCAGCTCTTCTCTAAAAGCAAGGATTTGGAATGAACAATTC
AGTTTGACAGAAAAAGCTGAATAAAATGGCATCTGTAATTGAATTGTTGGAAATGCCTTTTTTGCTCCTAAATTTTAAACATCATTAATA

>83915_83915_2_SMARCA5-LRBA_SMARCA5_chr4_144469293_ENST00000283131_LRBA_chr4_151358016_ENST00000535741_length(amino acids)=1587AA_BP=995
MSSAAEPPPPPPPESAPSKPAASIASGGSNSSNKGGPEGVAAQAVASAASAGPADAEMEEIFDDASPGKQKEIQEPDPTYEEKMQTDRAN
RFEYLLKQTELFAHFIQPAAQKTPTSPLKMKPGRPRIKKDEKQNLLSVGDYRHRRTEQEEDEELLTESSKATNVCTRFEDSPSYVKWGKL
RDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRNIPGPHMVLVPKSTLHNWMSEFKRWVPTLRSVCLIGDKEQRAAF
VRDVLLPGEWDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWSLLNFLLPDVFN
SADDFDSWFDTNNCLGDQKLVERLHMVLRPFLLRRIKADVEKSLPPKKEVKIYVGLSKMQREWYTRILMKDIDILNSAGKMDKMRLLNIL
MQLRKCCNHPYLFDGAEPGPPYTTDMHLVTNSGKMVVLDKLLPKLKEQGSRVLIFSQMTRVLDILEDYCMWRNYEYCRLDGQTPHDERQD
SINAYNEPNSTKFVFMLSTRAGGLGINLATADVVILYDSDWNPQVDLQAMDRAHRIGQTKTVRVFRFITDNTVEERIVERAEMKLRLDSI
VIQQGRLVDQNLNKIGKDEMLQMIRHGATHVFASKESEITDEDIDGILERGAKKTAEMNEKLSKMGESSLRNFTMDTESSVYNFEGEDYR
EKQKIAFTEWIEPPKRERKANYAVDAYFREALRVSEPKAPKAPRPPKQPNVQDFQFFPPRLFELLEKEILFYRKTIGYKVPRNPELPNAA
QAQKEEQLKIDEAESLNDEELEEKEKLLTQGFTNWNKRDFNQFIKANEKWGRDDIENIAREVEGKTPEEVIEYSAVFWERCNELQDIEKI
MAQIERGEARIQRRISIKKALDTKIGRYKAPFHQLRISYGTNKGKNYTEEEDRFLICMLHKLGFDKENVYDELRQCIRNSPQFRFDWFLK
SRTAMPIGALNPKRAAFFAERYESWEDDQVPKFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSISRAWRNSQRDTSD
IKELIPEFYYLPEMFVNFNNYNLGVMDDGTVVSDVELPPWAKTSEEFVHINRLALESEFVSCQLHQWIDLIFGYKQQGPEAVRALNVFYY
LTYEGAVNLNSITDPVLREAVEAQIRSFGQTPSQLLIEPHPPRGSAMQVSPLMFTDKAQQDVIMVLKFPSNSPVTHVAANTQPGLATPAV
ITVTANRLFAVNKWHNLPAHQGAVQDQPYQLPVEIDPLIASNTGMHRRQITDLLDQSIQVHSQCFVITSDNRYILVCGFWDKSFRVYSTD
TGRLIQVVFGHWDVVTCLARSESYIGGNCYILSGSRDATLLLWYWNGKCSGIGDNPGSETAAPRAILTGHDYEVTCAAVCAELGLVLSGS
QEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATMETDDNIRAIQLSRDGQYLLTGGDRGVVVVR

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Fusion Gene PPI Analysis for SMARCA5-LRBA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SMARCA5-LRBA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SMARCA5-LRBA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSMARCA5C0279980Extra-osseous Ewing's sarcoma1ORPHANET
TgeneC3553512IMMUNODEFICIENCY, COMMON VARIABLE, 8, WITH AUTOIMMUNITY7CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT