Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:TUBA1C-AKAP17A (FusionGDB2 ID:HG84790TG8227)

Fusion Gene Summary for TUBA1C-AKAP17A

check button Fusion gene summary
Fusion gene informationFusion gene name: TUBA1C-AKAP17A
Fusion gene ID: hg84790tg8227
HgeneTgene
Gene symbol

TUBA1C

AKAP17A

Gene ID

84790

8227

Gene nametubulin alpha 1cA-kinase anchoring protein 17A
SynonymsTUBA6|bcm948721P|AKAP-17A|CCDC133|CXYorf3|DXYS155E|PRKA17A|SFRS17A|XE7|XE7Y
Cytomap('TUBA1C')('AKAP17A')

12q13.12

Xp22.33 and Yp11.2

Type of geneprotein-codingprotein-coding
Descriptiontubulin alpha-1C chainalpha-tubulin 6tubulin alpha-6 chaintubulin, alpha 6A-kinase anchor protein 17AA kinase (PRKA) anchor protein 17AB-lymphocyte surface antigenprotein kinase A-anchoring protein 17Apseudoautosomal gene XE7splicing factor, arginine/serine-rich 17A
Modification date2020031320200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000301072, ENST00000541364, 
ENST00000549183, ENST00000550574, 
Fusion gene scores* DoF score19 X 16 X 6=18242 X 2 X 2=8
# samples 222
** MAII scorelog2(22/1824*10)=-3.05153030064008
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: TUBA1C [Title/Abstract] AND AKAP17A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTUBA1C(49663470)-AKAP17A(1669551), # samples:1
Anticipated loss of major functional domain due to fusion event.TUBA1C-AKAP17A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TUBA1C-AKAP17A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TUBA1C-AKAP17A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TUBA1C-AKAP17A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TUBA1C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across AKAP17A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer203NTUBA1Cchr12

49663470

+AKAP17AchrY

1669551

+


Top

Fusion Gene ORF analysis for TUBA1C-AKAP17A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000301072ENST00000381261TUBA1Cchr12

49663470

+AKAP17AchrY

1669551

+
5CDS-intronENST00000541364ENST00000381261TUBA1Cchr12

49663470

+AKAP17AchrY

1669551

+
5CDS-intronENST00000549183ENST00000381261TUBA1Cchr12

49663470

+AKAP17AchrY

1669551

+
In-frameENST00000301072ENST00000313871TUBA1Cchr12

49663470

+AKAP17AchrY

1669551

+
In-frameENST00000541364ENST00000313871TUBA1Cchr12

49663470

+AKAP17AchrY

1669551

+
In-frameENST00000549183ENST00000313871TUBA1Cchr12

49663470

+AKAP17AchrY

1669551

+
intron-3CDSENST00000550574ENST00000313871TUBA1Cchr12

49663470

+AKAP17AchrY

1669551

+
intron-intronENST00000550574ENST00000381261TUBA1Cchr12

49663470

+AKAP17AchrY

1669551

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000541364TUBA1Cchr1249663470+ENST00000313871AKAP17AchrY1669551+23204641514306402
ENST00000301072TUBA1Cchr1249663470+ENST00000313871AKAP17AchrY1669551+23575011551343402
ENST00000549183TUBA1Cchr1249663470+ENST00000313871AKAP17AchrY1669551+21833271377169402

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000541364ENST00000313871TUBA1Cchr1249663470+AKAP17AchrY1669551+0.34253550.6574645
ENST00000301072ENST00000313871TUBA1Cchr1249663470+AKAP17AchrY1669551+0.327755330.67224467
ENST00000549183ENST00000313871TUBA1Cchr1249663470+AKAP17AchrY1669551+0.28189230.7181077

Top

Fusion Genomic Features for TUBA1C-AKAP17A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TUBA1Cchr1249663470+AKAP17AchrY1669551+1.99E-050.9999801
TUBA1Cchr1249663470+AKAP17AchrY1669551+1.99E-050.9999801

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for TUBA1C-AKAP17A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:49663470/chrY:1669551)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAKAP17Achr12:49663470chrY:1669551ENST0000031387135587_695384696.0Compositional biasNote=Arg-rich
TgeneAKAP17Achr12:49663470chrY:1669551ENST0000031387135425_454384696.0RegionNote=PKA-RI-alpha subunit binding domain

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTUBA1Cchr12:49663470chrY:1669551ENST00000301072+24142_14875450.0Nucleotide bindingGTP
TgeneAKAP17Achr12:49663470chrY:1669551ENST0000031387135147_256384696.0DomainNote=RRM
TgeneAKAP17Achr12:49663470chrY:1669551ENST000003138713583_112384696.0RegionNote=PKA-RI and PKA-RII subunit binding domain


Top

Fusion Gene Sequence for TUBA1C-AKAP17A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>95301_95301_1_TUBA1C-AKAP17A_TUBA1C_chr12_49663470_ENST00000301072_AKAP17A_chrY_1669551_ENST00000313871_length(transcript)=2357nt_BP=501nt
GAACTTTTGAATCCGCCAATCAGCGCCGCGCGCCCCCACTCCGCGGGTGCGGCCGGGCGCAGGCCAGGGCTCGAAGGTGGGGCCGCAGCG
GCACGGGGCGGGGTCTGGGGCCCGCCCTCCCGACACGTGGCCGGGGACCGGGTATATAAGGCCCTTCGGGGCCGGCCACCCTTTCACTAC
TTCTCCCCCGGACTCCTTGGTAGTCTGTTAGTGGGAGATCCTTGTTGCCGTCCCTTCGCCTCCTTCACCGCCGCAGACCCCTTCAAGTTC
TAGTCATGCGTGAGTGCATCTCCATCCACGTTGGCCAGGCTGGTGTCCAGATTGGCAATGCCTGCTGGGAGCTCTACTGCCTGGAACACG
GCATCCAGCCCGATGGCCAGATGCCAAGTGACAAGACCATTGGGGGAGGAGATGATTCCTTCAACACCTTCTTCAGTGAAACGGGTGCTG
GCAAGCATGTGCCCCGGGCAGTGTTTGTAGACTTGGAACCCACAGTCATTGGCTGTGAAGCTACGGGAACAGGAGCAGAAGGAGGAGAAG
CTGAGGCTCCAGCAGCAGGAGGAGCGGCGGCGGCTGCAGGAGGCCGAGCTGCGGCGCGTGGAGGAGGAGAAGGAGCGCGCGCTGGGCCTG
CAGCGGAAAGAGCGGGAGCTGCGCGAGCGGCTGCTGAGCATCCTGCTGAGCAAGAAGCCGGACGACAGCCACACACACGACGAGCTGGGC
GTGGCACACGCCGACCTGCTGCAGCCCGTCCTGGACATCCTGCAGACCGTGTCGTCCGGCTGTGTGAGCGCCACCACGCTGCACCCCCTC
GGGGGCCAGCCCCCGGCCGGTGCCCCCAAGGAGAGCCCGGCCCACCCAGAGGCCGACGGCGCTCCCAAAAGCGTGAACGGGAGCGTGGCC
GAGGAGGCCCCATGCAAGGAGGTTCAGAGCTCCTGTCGTGTGGTCCCCGAGGATGGCTCTCCAGAGAAGAGGTGCCCGGGCGGCGTCCTC
TCCTGCATTCCTGACAACAACCAACAGCCCAAGGGCATCCCTGCCTGCGAGCAGAATGTCTCCAGAAAGGACACCCGGTCAGAACAGGAC
AAGTGCAACCGGGAGCCCAGCAAGGGCCGGGGCCGGGCCACCGGAGACGGGCTTGCTGACCGGCACAAGCGGGAGAGGAGCCGGGCCAGG
CGGGCCAGCAGCAGGGAGGACGGGAGGCCACGCAAGGAGCGGCGGCCCCACAAGAAGCACGCCTACAAGGATGACAGCCCCCGCCGGCGC
AGCACGAGCCCGGACCACACCCGGTCCCGGAGGTCCCACAGCAAAGACAGGCACCGGAGGGAGCGGAGCCGGGAGCGGAGGGGCAGCGCC
AGCAGGAAGCACAGCCGCCACCGCCGCCGAAGCGAGCGGTCGCGCTCCCGGTCCCCGAGCAGGCACCGCAGTACCTGGAACAGGTAATGA
CGGGCACGGCCTCCCCACGGCCTGTCCGGGAAAGACCAGGACCTGCTCGAGCCTCCTGGCCGCTCCTTGGCCGCTCTCCGTCCACCCCTG
CAAAGCCAAGACCCTTCTGCAGCCACGAATGTCCACGGAGCCCGCCGGCAGGAAGGAAGACACCATGCTTTAGAGATCCATCTTTCTCCA
CTCACCGCAGCGTACTTGGCACTTCAGTTTCAAACACGTAGTCCTTTAAAACTTGATCCGATAGCTTTAATGCGGCCGGTCCTCTCTCAG
TCAGGAAAATTGCACAGACCGACAGTCGTGAGGATGGCAGAGCTGCTGCATTCCCCCACACGGGGATTTCTGTGTCTGCTTGGCGACCTC
CCTGCGTGCACGGCCTAGGAGGTGCACGGGCCACCATAGTCACACTGGCACTGAAAAGAAAGCGTTGCCCTGGTGATTCTTTCCCCCCCG
TTTGTAATGTTAACTGATCAGGAAGTGCAGTTTGGGTGGGATGCCGAATCGTCGTGCTGACATTGAGTCACGGATGAGGAAGGTACAAGT
CCTTTAAGATCAAAACTCAAACGGGCCGTTCTTTCTAAGGTGTCGGTATGTGGGGAGTGGTACAAAATGGTCTGATGCTCCTTCAAAAAC
ATTCACTTTTTACAACGTCAAGGAATTAAGCATAAAAAAGATTGGTTAAAAGCTTTGGTTTCTAGTAAAGGTTAGTGTGTGTGGTTTTTT
TAAGAAGCTGTTTTGCTAAATTATTTTTACTTGGAATGTTTCAAACAGATTTCAGGCTGCAAACTTGTTTTATAATCGTTTGCTTCTCCA
AGTGAAGCTCAGAAATACCTAAAAATAGCTGTAACGTTCGCGTTAGGAAAGATGGTGTTTATTCCAGTTTGCATTTTTATGGTGAAATAA

>95301_95301_1_TUBA1C-AKAP17A_TUBA1C_chr12_49663470_ENST00000301072_AKAP17A_chrY_1669551_ENST00000313871_length(amino acids)=402AA_BP=1
MQKGLGFAGVDGERPRSGQEARAGPGLSRTGRGEAVPVITCSRYCGACSGTGSATARFGGGGGCASCWRCPSAPGSAPSGACLCCGTSGT
GCGPGSCCAGGGCHPCRRASCGAAAPCVASRPPCCWPAWPGSSPACAGQQARLRWPGPGPCWAPGCTCPVLTGCPFWRHSARRQGCPWAV
GCCQECRRGRRPGTSSLESHPRGPHDRSSEPPCMGPPRPRSRSRFWERRRPLGGPGSPWGHRPGAGPRGGAAWWRSHSRTTRSAGCPGRA
AAGRRVPRPARRVCGCRPASCSAGCSAAARAAPALSAAGPARAPSPPPRAAARPPAAAAAPPAAGASASPPSAPVPVASQPMTVGSKSTN

--------------------------------------------------------------
>95301_95301_2_TUBA1C-AKAP17A_TUBA1C_chr12_49663470_ENST00000541364_AKAP17A_chrY_1669551_ENST00000313871_length(transcript)=2320nt_BP=464nt
AAGTGAACAATGGGCGCCCAGCTCTAAAATGACAGCCTGGTTCAATGGGGTGGAGGAGCTAGGGAGGGATGAGTGCTTTGTGTGCTTGGA
ATTAGATCCTTCAAATGGATCCTTTCTGAATGCAAAACTGTACATCTCTAACTGGATTCTTATTTACTTCACCAGGACTCTTCAGCTCCC
TGCGCCTTTTAACACATGCACATCCAGCAAAAGCAGAGGAGAACCTGGCTGTGATTCAAAGCGTGAGTGCATCTCCATCCACGTTGGCCA
GGCTGGTGTCCAGATTGGCAATGCCTGCTGGGAGCTCTACTGCCTGGAACACGGCATCCAGCCCGATGGCCAGATGCCAAGTGACAAGAC
CATTGGGGGAGGAGATGATTCCTTCAACACCTTCTTCAGTGAAACGGGTGCTGGCAAGCATGTGCCCCGGGCAGTGTTTGTAGACTTGGA
ACCCACAGTCATTGGCTGTGAAGCTACGGGAACAGGAGCAGAAGGAGGAGAAGCTGAGGCTCCAGCAGCAGGAGGAGCGGCGGCGGCTGC
AGGAGGCCGAGCTGCGGCGCGTGGAGGAGGAGAAGGAGCGCGCGCTGGGCCTGCAGCGGAAAGAGCGGGAGCTGCGCGAGCGGCTGCTGA
GCATCCTGCTGAGCAAGAAGCCGGACGACAGCCACACACACGACGAGCTGGGCGTGGCACACGCCGACCTGCTGCAGCCCGTCCTGGACA
TCCTGCAGACCGTGTCGTCCGGCTGTGTGAGCGCCACCACGCTGCACCCCCTCGGGGGCCAGCCCCCGGCCGGTGCCCCCAAGGAGAGCC
CGGCCCACCCAGAGGCCGACGGCGCTCCCAAAAGCGTGAACGGGAGCGTGGCCGAGGAGGCCCCATGCAAGGAGGTTCAGAGCTCCTGTC
GTGTGGTCCCCGAGGATGGCTCTCCAGAGAAGAGGTGCCCGGGCGGCGTCCTCTCCTGCATTCCTGACAACAACCAACAGCCCAAGGGCA
TCCCTGCCTGCGAGCAGAATGTCTCCAGAAAGGACACCCGGTCAGAACAGGACAAGTGCAACCGGGAGCCCAGCAAGGGCCGGGGCCGGG
CCACCGGAGACGGGCTTGCTGACCGGCACAAGCGGGAGAGGAGCCGGGCCAGGCGGGCCAGCAGCAGGGAGGACGGGAGGCCACGCAAGG
AGCGGCGGCCCCACAAGAAGCACGCCTACAAGGATGACAGCCCCCGCCGGCGCAGCACGAGCCCGGACCACACCCGGTCCCGGAGGTCCC
ACAGCAAAGACAGGCACCGGAGGGAGCGGAGCCGGGAGCGGAGGGGCAGCGCCAGCAGGAAGCACAGCCGCCACCGCCGCCGAAGCGAGC
GGTCGCGCTCCCGGTCCCCGAGCAGGCACCGCAGTACCTGGAACAGGTAATGACGGGCACGGCCTCCCCACGGCCTGTCCGGGAAAGACC
AGGACCTGCTCGAGCCTCCTGGCCGCTCCTTGGCCGCTCTCCGTCCACCCCTGCAAAGCCAAGACCCTTCTGCAGCCACGAATGTCCACG
GAGCCCGCCGGCAGGAAGGAAGACACCATGCTTTAGAGATCCATCTTTCTCCACTCACCGCAGCGTACTTGGCACTTCAGTTTCAAACAC
GTAGTCCTTTAAAACTTGATCCGATAGCTTTAATGCGGCCGGTCCTCTCTCAGTCAGGAAAATTGCACAGACCGACAGTCGTGAGGATGG
CAGAGCTGCTGCATTCCCCCACACGGGGATTTCTGTGTCTGCTTGGCGACCTCCCTGCGTGCACGGCCTAGGAGGTGCACGGGCCACCAT
AGTCACACTGGCACTGAAAAGAAAGCGTTGCCCTGGTGATTCTTTCCCCCCCGTTTGTAATGTTAACTGATCAGGAAGTGCAGTTTGGGT
GGGATGCCGAATCGTCGTGCTGACATTGAGTCACGGATGAGGAAGGTACAAGTCCTTTAAGATCAAAACTCAAACGGGCCGTTCTTTCTA
AGGTGTCGGTATGTGGGGAGTGGTACAAAATGGTCTGATGCTCCTTCAAAAACATTCACTTTTTACAACGTCAAGGAATTAAGCATAAAA
AAGATTGGTTAAAAGCTTTGGTTTCTAGTAAAGGTTAGTGTGTGTGGTTTTTTTAAGAAGCTGTTTTGCTAAATTATTTTTACTTGGAAT
GTTTCAAACAGATTTCAGGCTGCAAACTTGTTTTATAATCGTTTGCTTCTCCAAGTGAAGCTCAGAAATACCTAAAAATAGCTGTAACGT

>95301_95301_2_TUBA1C-AKAP17A_TUBA1C_chr12_49663470_ENST00000541364_AKAP17A_chrY_1669551_ENST00000313871_length(amino acids)=402AA_BP=1
MQKGLGFAGVDGERPRSGQEARAGPGLSRTGRGEAVPVITCSRYCGACSGTGSATARFGGGGGCASCWRCPSAPGSAPSGACLCCGTSGT
GCGPGSCCAGGGCHPCRRASCGAAAPCVASRPPCCWPAWPGSSPACAGQQARLRWPGPGPCWAPGCTCPVLTGCPFWRHSARRQGCPWAV
GCCQECRRGRRPGTSSLESHPRGPHDRSSEPPCMGPPRPRSRSRFWERRRPLGGPGSPWGHRPGAGPRGGAAWWRSHSRTTRSAGCPGRA
AAGRRVPRPARRVCGCRPASCSAGCSAAARAAPALSAAGPARAPSPPPRAAARPPAAAAAPPAAGASASPPSAPVPVASQPMTVGSKSTN

--------------------------------------------------------------
>95301_95301_3_TUBA1C-AKAP17A_TUBA1C_chr12_49663470_ENST00000549183_AKAP17A_chrY_1669551_ENST00000313871_length(transcript)=2183nt_BP=327nt
CACTACTTCTCCCCCGGACTCCTTGGTAGTCTGTTAGTGGGAGATCCTTGTTGCCGTCCCTTCGCCTCCTTCACCGCCGCAGACCCCTTC
AAGTTCTAGTCATGCGTGAGTGCATCTCCATCCACGTTGGCCAGGCTGGTGTCCAGATTGGCAATGCCTGCTGGGAGCTCTACTGCCTGG
AACACGGCATCCAGCCCGATGGCCAGATGCCAAGTGACAAGACCATTGGGGGAGGAGATGATTCCTTCAACACCTTCTTCAGTGAAACGG
GTGCTGGCAAGCATGTGCCCCGGGCAGTGTTTGTAGACTTGGAACCCACAGTCATTGGCTGTGAAGCTACGGGAACAGGAGCAGAAGGAG
GAGAAGCTGAGGCTCCAGCAGCAGGAGGAGCGGCGGCGGCTGCAGGAGGCCGAGCTGCGGCGCGTGGAGGAGGAGAAGGAGCGCGCGCTG
GGCCTGCAGCGGAAAGAGCGGGAGCTGCGCGAGCGGCTGCTGAGCATCCTGCTGAGCAAGAAGCCGGACGACAGCCACACACACGACGAG
CTGGGCGTGGCACACGCCGACCTGCTGCAGCCCGTCCTGGACATCCTGCAGACCGTGTCGTCCGGCTGTGTGAGCGCCACCACGCTGCAC
CCCCTCGGGGGCCAGCCCCCGGCCGGTGCCCCCAAGGAGAGCCCGGCCCACCCAGAGGCCGACGGCGCTCCCAAAAGCGTGAACGGGAGC
GTGGCCGAGGAGGCCCCATGCAAGGAGGTTCAGAGCTCCTGTCGTGTGGTCCCCGAGGATGGCTCTCCAGAGAAGAGGTGCCCGGGCGGC
GTCCTCTCCTGCATTCCTGACAACAACCAACAGCCCAAGGGCATCCCTGCCTGCGAGCAGAATGTCTCCAGAAAGGACACCCGGTCAGAA
CAGGACAAGTGCAACCGGGAGCCCAGCAAGGGCCGGGGCCGGGCCACCGGAGACGGGCTTGCTGACCGGCACAAGCGGGAGAGGAGCCGG
GCCAGGCGGGCCAGCAGCAGGGAGGACGGGAGGCCACGCAAGGAGCGGCGGCCCCACAAGAAGCACGCCTACAAGGATGACAGCCCCCGC
CGGCGCAGCACGAGCCCGGACCACACCCGGTCCCGGAGGTCCCACAGCAAAGACAGGCACCGGAGGGAGCGGAGCCGGGAGCGGAGGGGC
AGCGCCAGCAGGAAGCACAGCCGCCACCGCCGCCGAAGCGAGCGGTCGCGCTCCCGGTCCCCGAGCAGGCACCGCAGTACCTGGAACAGG
TAATGACGGGCACGGCCTCCCCACGGCCTGTCCGGGAAAGACCAGGACCTGCTCGAGCCTCCTGGCCGCTCCTTGGCCGCTCTCCGTCCA
CCCCTGCAAAGCCAAGACCCTTCTGCAGCCACGAATGTCCACGGAGCCCGCCGGCAGGAAGGAAGACACCATGCTTTAGAGATCCATCTT
TCTCCACTCACCGCAGCGTACTTGGCACTTCAGTTTCAAACACGTAGTCCTTTAAAACTTGATCCGATAGCTTTAATGCGGCCGGTCCTC
TCTCAGTCAGGAAAATTGCACAGACCGACAGTCGTGAGGATGGCAGAGCTGCTGCATTCCCCCACACGGGGATTTCTGTGTCTGCTTGGC
GACCTCCCTGCGTGCACGGCCTAGGAGGTGCACGGGCCACCATAGTCACACTGGCACTGAAAAGAAAGCGTTGCCCTGGTGATTCTTTCC
CCCCCGTTTGTAATGTTAACTGATCAGGAAGTGCAGTTTGGGTGGGATGCCGAATCGTCGTGCTGACATTGAGTCACGGATGAGGAAGGT
ACAAGTCCTTTAAGATCAAAACTCAAACGGGCCGTTCTTTCTAAGGTGTCGGTATGTGGGGAGTGGTACAAAATGGTCTGATGCTCCTTC
AAAAACATTCACTTTTTACAACGTCAAGGAATTAAGCATAAAAAAGATTGGTTAAAAGCTTTGGTTTCTAGTAAAGGTTAGTGTGTGTGG
TTTTTTTAAGAAGCTGTTTTGCTAAATTATTTTTACTTGGAATGTTTCAAACAGATTTCAGGCTGCAAACTTGTTTTATAATCGTTTGCT
TCTCCAAGTGAAGCTCAGAAATACCTAAAAATAGCTGTAACGTTCGCGTTAGGAAAGATGGTGTTTATTCCAGTTTGCATTTTTATGGTG

>95301_95301_3_TUBA1C-AKAP17A_TUBA1C_chr12_49663470_ENST00000549183_AKAP17A_chrY_1669551_ENST00000313871_length(amino acids)=402AA_BP=1
MQKGLGFAGVDGERPRSGQEARAGPGLSRTGRGEAVPVITCSRYCGACSGTGSATARFGGGGGCASCWRCPSAPGSAPSGACLCCGTSGT
GCGPGSCCAGGGCHPCRRASCGAAAPCVASRPPCCWPAWPGSSPACAGQQARLRWPGPGPCWAPGCTCPVLTGCPFWRHSARRQGCPWAV
GCCQECRRGRRPGTSSLESHPRGPHDRSSEPPCMGPPRPRSRSRFWERRRPLGGPGSPWGHRPGAGPRGGAAWWRSHSRTTRSAGCPGRA
AAGRRVPRPARRVCGCRPASCSAGCSAAARAAPALSAAGPARAPSPPPRAAARPPAAAAAPPAAGASASPPSAPVPVASQPMTVGSKSTN

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TUBA1C-AKAP17A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for TUBA1C-AKAP17A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for TUBA1C-AKAP17A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTUBA1CC0024623Malignant neoplasm of stomach1CTD_human
HgeneTUBA1CC0038356Stomach Neoplasms1CTD_human
HgeneTUBA1CC0948089Acute Coronary Syndrome1CTD_human
HgeneTUBA1CC1708349Hereditary Diffuse Gastric Cancer1CTD_human