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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CBR4-ERBB4 (FusionGDB2 ID:HG84869TG2066)

Fusion Gene Summary for CBR4-ERBB4

check button Fusion gene summary
Fusion gene informationFusion gene name: CBR4-ERBB4
Fusion gene ID: hg84869tg2066
HgeneTgene
Gene symbol

CBR4

ERBB4

Gene ID

84869

2066

Gene namecarbonyl reductase 4erb-b2 receptor tyrosine kinase 4
SynonymsSDR45C1ALS19|HER4|p180erbB4
Cytomap('CBR4')('ERBB4')

4q32.3

2q34

Type of geneprotein-codingprotein-coding
Descriptioncarbonyl reductase family member 43-ketoacyl-[acyl-carrier-protein] reductase beta subunit3-oxoacyl-[acyl-carrier-protein] reductaseKAR beta subunitcarbonic reductase 4quinone reductase CBR4short chain dehydrogenase/reductase family 45C member 1receptor tyrosine-protein kinase erbB-4avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4human epidermal growth factor receptor 4proto-oncogene-like protein c-ErbB-4tyrosine kinase-type cell surface receptor HER4v-erb-a erythroblastic
Modification date2020031320200327
UniProtAcc.

Q15303

Ensembl transtripts involved in fusion geneENST00000306193, ENST00000509108, 
ENST00000504480, 
Fusion gene scores* DoF score6 X 4 X 5=12018 X 16 X 8=2304
# samples 617
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/2304*10)=-3.76053406530461
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CBR4 [Title/Abstract] AND ERBB4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCBR4(169923222)-ERBB4(212989628), # samples:2
Anticipated loss of major functional domain due to fusion event.CBR4-ERBB4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CBR4-ERBB4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCBR4

GO:0051289

protein homotetramerization

19000905

HgeneCBR4

GO:0051290

protein heterotetramerization

25203508

HgeneCBR4

GO:0055114

oxidation-reduction process

25203508

TgeneERBB4

GO:0007165

signal transduction

10572067

TgeneERBB4

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

10353604|18334220

TgeneERBB4

GO:0016477

cell migration

9135143

TgeneERBB4

GO:0018108

peptidyl-tyrosine phosphorylation

18334220

TgeneERBB4

GO:0046777

protein autophosphorylation

18334220


check buttonFusion gene breakpoints across CBR4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ERBB4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A10E-01ACBR4chr4

169923222

-ERBB4chr2

212989628

-


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Fusion Gene ORF analysis for CBR4-ERBB4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000306193ENST00000484474CBR4chr4

169923222

-ERBB4chr2

212989628

-
5UTR-3CDSENST00000509108ENST00000342788CBR4chr4

169923222

-ERBB4chr2

212989628

-
5UTR-3CDSENST00000509108ENST00000402597CBR4chr4

169923222

-ERBB4chr2

212989628

-
5UTR-3CDSENST00000509108ENST00000436443CBR4chr4

169923222

-ERBB4chr2

212989628

-
5UTR-intronENST00000509108ENST00000484474CBR4chr4

169923222

-ERBB4chr2

212989628

-
In-frameENST00000306193ENST00000342788CBR4chr4

169923222

-ERBB4chr2

212989628

-
In-frameENST00000306193ENST00000402597CBR4chr4

169923222

-ERBB4chr2

212989628

-
In-frameENST00000306193ENST00000436443CBR4chr4

169923222

-ERBB4chr2

212989628

-
intron-3CDSENST00000504480ENST00000342788CBR4chr4

169923222

-ERBB4chr2

212989628

-
intron-3CDSENST00000504480ENST00000402597CBR4chr4

169923222

-ERBB4chr2

212989628

-
intron-3CDSENST00000504480ENST00000436443CBR4chr4

169923222

-ERBB4chr2

212989628

-
intron-intronENST00000504480ENST00000484474CBR4chr4

169923222

-ERBB4chr2

212989628

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000306193CBR4chr4169923222-ENST00000436443ERBB4chr2212989628-1239570411545001461
ENST00000306193CBR4chr4169923222-ENST00000342788ERBB4chr2212989628-1244370411545481477
ENST00000306193CBR4chr4169923222-ENST00000402597ERBB4chr2212989628-451970411545181468

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000306193ENST00000436443CBR4chr4169923222-ERBB4chr2212989628-7.97E-050.99992025
ENST00000306193ENST00000342788CBR4chr4169923222-ERBB4chr2212989628-0.0001108520.99988914
ENST00000306193ENST00000402597CBR4chr4169923222-ERBB4chr2212989628-0.0001588530.9998411

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Fusion Genomic Features for CBR4-ERBB4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CBR4-ERBB4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:169923222/chr2:212989628)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ERBB4

Q15303

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. {ECO:0000269|PubMed:10348342, ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:10722704, ECO:0000269|PubMed:10867024, ECO:0000269|PubMed:11178955, ECO:0000269|PubMed:11390655, ECO:0000269|PubMed:12807903, ECO:0000269|PubMed:15534001, ECO:0000269|PubMed:15746097, ECO:0000269|PubMed:16251361, ECO:0000269|PubMed:16778220, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:17486069, ECO:0000269|PubMed:17638867, ECO:0000269|PubMed:19098003, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:8383326, ECO:0000269|PubMed:8617750, ECO:0000269|PubMed:9135143, ECO:0000269|PubMed:9168115, ECO:0000269|PubMed:9334263}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCBR4chr4:169923222chr2:212989628ENST00000306193-4511_14178238.0Nucleotide bindingNADP
HgeneCBR4chr4:169923222chr2:212989628ENST00000306193-4534_35178238.0Nucleotide bindingNADP
HgeneCBR4chr4:169923222chr2:212989628ENST00000306193-4583_85178238.0Nucleotide bindingNADP
TgeneERBB4chr4:169923222chr2:212989628ENST00000342788028186_334271309.0Compositional biasNote=Cys-rich
TgeneERBB4chr4:169923222chr2:212989628ENST00000342788028496_633271309.0Compositional biasNote=Cys-rich
TgeneERBB4chr4:169923222chr2:212989628ENST00000402597028186_334271299.0Compositional biasNote=Cys-rich
TgeneERBB4chr4:169923222chr2:212989628ENST00000402597028496_633271299.0Compositional biasNote=Cys-rich
TgeneERBB4chr4:169923222chr2:212989628ENST00000436443027186_334271293.0Compositional biasNote=Cys-rich
TgeneERBB4chr4:169923222chr2:212989628ENST00000436443027496_633271293.0Compositional biasNote=Cys-rich
TgeneERBB4chr4:169923222chr2:212989628ENST00000342788028718_985271309.0DomainProtein kinase
TgeneERBB4chr4:169923222chr2:212989628ENST00000402597028718_985271299.0DomainProtein kinase
TgeneERBB4chr4:169923222chr2:212989628ENST00000436443027718_985271293.0DomainProtein kinase
TgeneERBB4chr4:169923222chr2:212989628ENST000003427880281032_1035271309.0MotifNote=PPxY motif 1
TgeneERBB4chr4:169923222chr2:212989628ENST000003427880281053_1056271309.0MotifNote=PPxY motif 2
TgeneERBB4chr4:169923222chr2:212989628ENST000003427880281298_1301271309.0MotifNote=PPxY motif 3
TgeneERBB4chr4:169923222chr2:212989628ENST000003427880281306_1308271309.0MotifNote=PDZ-binding
TgeneERBB4chr4:169923222chr2:212989628ENST00000342788028676_684271309.0MotifNote=Nuclear localization signal
TgeneERBB4chr4:169923222chr2:212989628ENST000004025970281032_1035271299.0MotifNote=PPxY motif 1
TgeneERBB4chr4:169923222chr2:212989628ENST000004025970281053_1056271299.0MotifNote=PPxY motif 2
TgeneERBB4chr4:169923222chr2:212989628ENST000004025970281298_1301271299.0MotifNote=PPxY motif 3
TgeneERBB4chr4:169923222chr2:212989628ENST000004025970281306_1308271299.0MotifNote=PDZ-binding
TgeneERBB4chr4:169923222chr2:212989628ENST00000402597028676_684271299.0MotifNote=Nuclear localization signal
TgeneERBB4chr4:169923222chr2:212989628ENST000004364430271032_1035271293.0MotifNote=PPxY motif 1
TgeneERBB4chr4:169923222chr2:212989628ENST000004364430271053_1056271293.0MotifNote=PPxY motif 2
TgeneERBB4chr4:169923222chr2:212989628ENST000004364430271298_1301271293.0MotifNote=PPxY motif 3
TgeneERBB4chr4:169923222chr2:212989628ENST000004364430271306_1308271293.0MotifNote=PDZ-binding
TgeneERBB4chr4:169923222chr2:212989628ENST00000436443027676_684271293.0MotifNote=Nuclear localization signal
TgeneERBB4chr4:169923222chr2:212989628ENST00000342788028724_732271309.0Nucleotide bindingATP
TgeneERBB4chr4:169923222chr2:212989628ENST00000342788028797_799271309.0Nucleotide bindingATP
TgeneERBB4chr4:169923222chr2:212989628ENST00000342788028843_848271309.0Nucleotide bindingATP
TgeneERBB4chr4:169923222chr2:212989628ENST00000402597028724_732271299.0Nucleotide bindingATP
TgeneERBB4chr4:169923222chr2:212989628ENST00000402597028797_799271299.0Nucleotide bindingATP
TgeneERBB4chr4:169923222chr2:212989628ENST00000402597028843_848271299.0Nucleotide bindingATP
TgeneERBB4chr4:169923222chr2:212989628ENST00000436443027724_732271293.0Nucleotide bindingATP
TgeneERBB4chr4:169923222chr2:212989628ENST00000436443027797_799271293.0Nucleotide bindingATP
TgeneERBB4chr4:169923222chr2:212989628ENST00000436443027843_848271293.0Nucleotide bindingATP
TgeneERBB4chr4:169923222chr2:212989628ENST0000034278802826_651271309.0Topological domainExtracellular
TgeneERBB4chr4:169923222chr2:212989628ENST00000342788028676_1308271309.0Topological domainCytoplasmic
TgeneERBB4chr4:169923222chr2:212989628ENST0000040259702826_651271299.0Topological domainExtracellular
TgeneERBB4chr4:169923222chr2:212989628ENST00000402597028676_1308271299.0Topological domainCytoplasmic
TgeneERBB4chr4:169923222chr2:212989628ENST0000043644302726_651271293.0Topological domainExtracellular
TgeneERBB4chr4:169923222chr2:212989628ENST00000436443027676_1308271293.0Topological domainCytoplasmic
TgeneERBB4chr4:169923222chr2:212989628ENST00000342788028652_675271309.0TransmembraneHelical
TgeneERBB4chr4:169923222chr2:212989628ENST00000402597028652_675271299.0TransmembraneHelical
TgeneERBB4chr4:169923222chr2:212989628ENST00000436443027652_675271293.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCBR4chr4:169923222chr2:212989628ENST00000306193-45181_183178238.0Nucleotide bindingNADP
HgeneCBR4chr4:169923222chr2:212989628ENST00000504480-1411_140180.0Nucleotide bindingNADP
HgeneCBR4chr4:169923222chr2:212989628ENST00000504480-14181_1830180.0Nucleotide bindingNADP
HgeneCBR4chr4:169923222chr2:212989628ENST00000504480-1434_350180.0Nucleotide bindingNADP
HgeneCBR4chr4:169923222chr2:212989628ENST00000504480-1483_850180.0Nucleotide bindingNADP


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Fusion Gene Sequence for CBR4-ERBB4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>13417_13417_1_CBR4-ERBB4_CBR4_chr4_169923222_ENST00000306193_ERBB4_chr2_212989628_ENST00000342788_length(transcript)=12443nt_BP=704nt
ATTACTATTGTGCGGCTGCAGGAGGTGTCGAGCGGCGTTATTTTTTTTTGCGGTTTGCCTTTTTTTTTCTTTTTTTTTTTTTTGGAACCG
CGGTTGTTTAAAAGCCTGAGGGAACCTGGAGAGGGGCTCCCACTCCCTACCCTCTTTCCTCCGAGTTTGTGACTCCGAGATGGACAAAGT
GTGTGCTGTTTTTGGAGGCTCCCGAGGCATTGGCAGAGCTGTGGCCCAGTTAATGGCCCGGAAAGGCTACCGACTGGCGGTCATTGCCAG
AAACCTGGAAGGGGCCAAAGCCGCCGCCGGTGACCTCGGCGGAGATCATTTGGCATTTAGCTGTGATGTTGCTAAAGAACATGATGTTCA
AAATACATTTGAAGAGCTGGAGAAACATTTAGGTCGAGTAAATTTCTTGGTAAATGCAGCTGGTATTAACAGGGATGGTCTTTTAGTAAG
AACAAAAACTGAAGATATGGTATCTCAGCTTCATACTAACCTCTTGGGTTCCATGCTGACCTGTAAAGCTGCCATGAGGACTATGATTCA
ACAACAGGGAGGGTCTATTGTTAATGTAGGAAGCATTGTTGGCTTAAAAGGCAACTCTGGCCAGTCCGTTTACAGTGCCAGTAAAGGAGG
ATTAGTTGGATTTTCACGTGCTCTTGCTAAAGAGGTAGCAAGAAAGAAAATTAGAGTGAATGTAGTTGCACCAGTGTGTGCAGGAACGGA
GAATAAACTGAGCTCTCTCTCTGACCTGGAACAGCAGTACCGAGCCTTGCGCAAGTACTATGAAAACTGTGAGGTTGTCATGGGCAACCT
GGAGATAACCAGCATTGAGCACAACCGGGACCTCTCCTTCCTGCGGTCTGTTCGAGAAGTCACAGGCTACGTGTTAGTGGCTCTTAATCA
GTTTCGTTACCTGCCTCTGGAGAATTTACGCATTATTCGTGGGACAAAACTTTATGAGGATCGATATGCCTTGGCAATATTTTTAAACTA
CAGAAAAGATGGAAACTTTGGACTTCAAGAACTTGGATTAAAGAACTTGACAGAAATCCTAAATGGTGGAGTCTATGTAGACCAGAACAA
ATTCCTTTGTTATGCAGACACCATTCATTGGCAAGATATTGTTCGGAACCCATGGCCTTCCAACTTGACTCTTGTGTCAACAAATGGTAG
TTCAGGATGTGGACGTTGCCATAAGTCCTGTACTGGCCGTTGCTGGGGACCCACAGAAAATCATTGCCAGACTTTGACAAGGACGGTGTG
TGCAGAACAATGTGACGGCAGATGCTACGGACCTTACGTCAGTGACTGCTGCCATCGAGAATGTGCTGGAGGCTGCTCAGGACCTAAGGA
CACAGACTGCTTTGCCTGCATGAATTTCAATGACAGTGGAGCATGTGTTACTCAGTGTCCCCAAACCTTTGTCTACAATCCAACCACCTT
TCAACTGGAGCACAATTTCAATGCAAAGTACACATATGGAGCATTCTGTGTCAAGAAATGTCCACATAACTTTGTGGTAGATTCCAGTTC
TTGTGTGCGTGCCTGCCCTAGTTCCAAGATGGAAGTAGAAGAAAATGGGATTAAAATGTGTAAACCTTGCACTGACATTTGCCCAAAAGC
TTGTGATGGCATTGGCACAGGATCATTGATGTCAGCTCAGACTGTGGATTCCAGTAACATTGACAAATTCATAAACTGTACCAAGATCAA
TGGGAATTTGATCTTTCTAGTCACTGGTATTCATGGGGACCCTTACAATGCAATTGAAGCCATAGACCCAGAGAAACTGAACGTCTTTCG
GACAGTCAGAGAGATAACAGGTTTCCTGAACATACAGTCATGGCCACCAAACATGACTGACTTCAGTGTTTTTTCTAACCTGGTGACCAT
TGGTGGAAGAGTACTCTATAGTGGCCTGTCCTTGCTTATCCTCAAGCAACAGGGCATCACCTCTCTACAGTTCCAGTCCCTGAAGGAAAT
CAGCGCAGGAAACATCTATATTACTGACAACAGCAACCTGTGTTATTATCATACCATTAACTGGACAACACTCTTCAGCACAATCAACCA
GAGAATAGTAATCCGGGACAACAGAAAAGCTGAAAATTGTACTGCTGAAGGAATGGTGTGCAACCATCTGTGTTCCAGTGATGGCTGTTG
GGGACCTGGGCCAGACCAATGTCTGTCGTGTCGCCGCTTCAGTAGAGGAAGGATCTGCATAGAGTCTTGTAACCTCTATGATGGTGAATT
TCGGGAGTTTGAGAATGGCTCCATCTGTGTGGAGTGTGACCCCCAGTGTGAGAAGATGGAAGATGGCCTCCTCACATGCCATGGACCGGG
TCCTGACAACTGTACAAAGTGCTCTCATTTTAAAGATGGCCCAAACTGTGTGGAAAAATGTCCAGATGGCTTACAGGGGGCAAACAGTTT
CATTTTCAAGTATGCTGATCCAGATCGGGAGTGCCACCCATGCCATCCAAACTGCACCCAAGGGTGTAACGGTCCCACTAGTCATGACTG
CATTTACTACCCATGGACGGGCCATTCCACTTTACCACAACATGCTAGAACTCCCCTGATTGCAGCTGGAGTAATTGGTGGGCTCTTCAT
TCTGGTCATTGTGGGTCTGACATTTGCTGTTTATGTTAGAAGGAAGAGCATCAAAAAGAAAAGAGCCTTGAGAAGATTCTTGGAAACAGA
GTTGGTGGAACCATTAACTCCCAGTGGCACAGCACCCAATCAAGCTCAACTTCGTATTTTGAAAGAAACTGAGCTGAAGAGGGTAAAAGT
CCTTGGCTCAGGTGCTTTTGGAACGGTTTATAAAGGTATTTGGGTACCTGAAGGAGAAACTGTGAAGATTCCTGTGGCTATTAAGATTCT
TAATGAGACAACTGGTCCCAAGGCAAATGTGGAGTTCATGGATGAAGCTCTGATCATGGCAAGTATGGATCATCCACACCTAGTCCGGTT
GCTGGGTGTGTGTCTGAGCCCAACCATCCAGCTGGTTACTCAACTTATGCCCCATGGCTGCCTGTTGGAGTATGTCCACGAGCACAAGGA
TAACATTGGATCACAACTGCTGCTTAACTGGTGTGTCCAGATAGCTAAGGGAATGATGTACCTGGAAGAAAGACGACTCGTTCATCGGGA
TTTGGCAGCCCGTAATGTCTTAGTGAAATCTCCAAACCATGTGAAAATCACAGATTTTGGGCTAGCCAGACTCTTGGAAGGAGATGAAAA
AGAGTACAATGCTGATGGAGGAAAGATGCCAATTAAATGGATGGCTCTGGAGTGTATACATTACAGGAAATTCACCCATCAGAGTGACGT
TTGGAGCTATGGAGTTACTATATGGGAACTGATGACCTTTGGAGGAAAACCCTATGATGGAATTCCAACGCGAGAAATCCCTGATTTATT
AGAGAAAGGAGAACGTTTGCCTCAGCCTCCCATCTGCACTATTGACGTTTACATGGTCATGGTCAAATGTTGGATGATTGATGCTGACAG
TAGACCTAAATTTAAGGAACTGGCTGCTGAGTTTTCAAGGATGGCTCGAGACCCTCAAAGATACCTAGTTATTCAGGGTGATGATCGTAT
GAAGCTTCCCAGTCCAAATGACAGCAAGTTCTTTCAGAATCTCTTGGATGAAGAGGATTTGGAAGATATGATGGATGCTGAGGAGTACTT
GGTCCCTCAGGCTTTCAACATCCCACCTCCCATCTATACTTCCAGAGCAAGAATTGACTCGAATAGGAGTGAAATTGGACACAGCCCTCC
TCCTGCCTACACCCCCATGTCAGGAAACCAGTTTGTATACCGAGATGGAGGTTTTGCTGCTGAACAAGGAGTGTCTGTGCCCTACAGAGC
CCCAACTAGCACAATTCCAGAAGCTCCTGTGGCACAGGGTGCTACTGCTGAGATTTTTGATGACTCCTGCTGTAATGGCACCCTACGCAA
GCCAGTGGCACCCCATGTCCAAGAGGACAGTAGCACCCAGAGGTACAGTGCTGACCCCACCGTGTTTGCCCCAGAACGGAGCCCACGAGG
AGAGCTGGATGAGGAAGGTTACATGACTCCTATGCGAGACAAACCCAAACAAGAATACCTGAATCCAGTGGAGGAGAACCCTTTTGTTTC
TCGGAGAAAAAATGGAGACCTTCAAGCATTGGATAATCCCGAATATCACAATGCATCCAATGGTCCACCCAAGGCCGAGGATGAGTATGT
GAATGAGCCACTGTACCTCAACACCTTTGCCAACACCTTGGGAAAAGCTGAGTACCTGAAGAACAACATACTGTCAATGCCAGAGAAGGC
CAAGAAAGCGTTTGACAACCCTGACTACTGGAACCACAGCCTGCCACCTCGGAGCACCCTTCAGCACCCAGACTACCTGCAGGAGTACAG
CACAAAATATTTTTATAAACAGAATGGGCGGATCCGGCCTATTGTGGCAGAGAATCCTGAATACCTCTCTGAGTTCTCCCTGAAGCCAGG
CACTGTGCTGCCGCCTCCACCTTACAGACACCGGAATACTGTGGTGTAAGCTCAGTTGTGGTTTTTTAGGTGGAGAGACACACCTGCTCC
AATTTCCCCACCCCCCTCTCTTTCTCTGGTGGTCTTCCTTCTACCCCAAGGCCAGTAGTTTTGACACTTCCCAGTGGAAGATACAGAGAT
GCAATGATAGTTATGTGCTTACCTAACTTGAACATTAGAGGGAAAGACTGAAAGAGAAAGATAGGAGGAACCACAATGTTTCTTCATTTC
TCTGCATGGGTTGGTCAGGAGAATGAAACAGCTAGAGAAGGACCAGAAAATGTAAGGCAATGCTGCCTACTATCAAACTAGCTGTCACTT
TTTTTCTTTTTCTTTTTCTTTCTTTGTTTCTTTCTTCCTCTTCTTTTTTTTTTTTTTTTTTAAAGCAGATGGTTGAAACACCCATGCTAT
CTGTTCCTATCTGCAGGAACTGATGTGTGCATATTTAGCATCCCTGGAAATCATAATAAAGTTTCCATTAGAACAAAAGAATAACATTTT
CTATAACATATGATGGTGTCTGAAATTGAGAATCCAGTTTCTTTCCCCAGCAGTTTCTGTCCTAGCAAGTAAGAATGGCCAACTCAACTT
TCATAATTTAAAAATCTCCATTAAAGTTATAACTAGTAATTATGTTTTCAACACTTTTTGGTTTTTTTCATTTTGTTTTGCTCTGACCGA
TTCCTTTATATTTGCTCCCCTATTTTTGGCTTTAATTTCTAATTGCAAAGATGTTTACATCAAAGCTTCTTCACAGAATTTAAGCAAGAA
ATATTTTAATATAGTGAAATGGCCACTACTTTAAGTATACAATCTTTAAAATAAGAAAGGGAGGCTAATATTTTTCATGCTATCAAATTA
TCTTCACCCTCATCCTTTACATTTTTCAACATTTTTTTTTCTCCATAAATGACACTACTTGATAGGCCGTTGGTTGTCTGAAGAGTAGAA
GGGAAACTAAGAGACAGTTCTCTGTGGTTCAGGAAAACTACTGATACTTTCAGGGGTGGCCCAATGAGGGAATCCATTGAACTGGAAGAA
ACACACTGGATTGGGTATGTCTACCTGGCAGATACTCAGAAATGTAGTTTGCACTTAAGCTGTAATTTTATTTGTTCTTTTTCTGAACTC
CATTTTGGATTTTGAATCAAGCAATATGGAAGCAACCAGCAAATTAACTAATTTAAGTACATTTTTAAAAAAAGAGCTAAGATAAAGACT
GTGGAAATGCCAAACCAAGCAAATTAGGAACCTTGCAACGGTATCCAGGGACTATGATGAGAGGCCAGCACATTATCTTCATATGTCACC
TTTGCTACGCAAGGAAATTTGTTCAGTTCGTATACTTCGTAAGAAGGAATGCGAGTAAGGATTGGCTTGAATTCCATGGAATTTCTAGTA
TGAGACTATTTATATGAAGTAGAAGGTAACTCTTTGCACATAAATTGGTATAATAAAAAGAAAAACACAAACATTCAAAGCTTAGGGATA
GGTCCTTGGGTCAAAAGTTGTAAATAAATGTGAAACATCTTCTCATGCAATTATTTTATTATCCAACACACTAATCTTTTGATACTTTAT
ATAATTCCCTTTCTTCATATACTGCATCCAGTACTAGAACCATCATTATTATGTATCATTTTGAAAGAATACCTGATGAGATGAAGGATG
AGAACAAATGACAGAGATGAGTCTCCAAGTAAAGGGGGCCTCACATCAATAATTAGGAAACTTAGATATAAGTCGCCCTTTTCTGAAAAT
TCTACCCCAAGTCATTTAGATTTTTAAAAAATATTTCTAATGTTAAAATATTGGGACCAAATTAGAATCAATAGTATAAGATTAATTAAT
TAGAGTAAAAATATCTATTAAGGCAGAGAAAGTTTAGAGAAAAAAATCCAAAGAAATTTGTGTTTCTTCCTATTCTGAACAAGTAAATCC
ATCCATCCATCCATCCAAACCTCCTTTATCTAACTGTGTCTACTAAAAGCACCATGTTTTGTGGGGAACACTCAGATAAATGGAATATCA
TCCTCAACTTCAAAATTCTATGATCTAGGAGATTTAATTAAAATGACATTTTAATTTTTCTATGCGTTCCAACAATCAGATTGCATAGTC
TCTTTTGTGAATAGCTGTCATATAATCAGTTGTACTGTAAGATATCTCCTTTAAACTCATTTGGGATATAAGTTAAACATCCTTCAAATT
GTTGATGTTGACAAACAGGATAATTTCAATAATATTATTCAAACATAAACTGGTCTAGGAGAATATTGCATCACTGACTAATTAGCCTAT
CTAGAGTCTAACTTCACCATTAAACCAAAAGCAGATGGTGGTCCTTGGCCAAGAATATTGGAGACATTGGAGTTGGTTTTTTTCTAAGCT
ATAAGAAGTGAGGCGAGCTGAAAAAGTATGGTAGAGCAGGAGAAGGGTTTGTGAGATTCCTTCTAGTGAAGTTCACCCTCAAACTTTTCA
GGGGTAAAGACACAGAGTGATTCAGGGGCCACAATCTAATAGCTCAGGGCTCTCCTATCCATTCAGAGAAGTCTCTAGGAAAAGGGATCT
CATATCAGTACTTATGAAAAATTGAATATAAGCCTCCCTTTCTAAATAAATCTGCATCGAGTCATCACAGCCCTCTTTTTGGATACTATA
CCTTGATTTTTTTTTTCTGATTTACAATATGCATATGGTTTCTACTGGGCTATAGAAAGCAGAATCACTCATTTTGGAGAAGGAAAAAAT
GAATAGTTAAAACAAACTTTTAACTGTTAAGGTAACAGAAATGTATTTAGTGAATGTCTCTTTCCTCCTAAGAACACAAGACTTCTACAT
GTTGGGTAATACCTAGAGATGCATGTAGGAATAATCCAAAATGACCCAAATGCTTTATAATAGCACCACTTTATAATTCTTTTGAATGAT
TTCTGTAGTATATAATTGACTTCAGTTGTTTGAGTGTTTTTTGTTTTATTTTTGTCCCCCCTGGGAAAACATATTTCAGCATGTATAAGA
GGGAGAAAAAAAGTTTCATTCCTTCCAGAGAATAACTTATTTAGTCCAGTAGGGTAGAATTTTAAAATGTCAGTTAAAGTCTTCAAAGTG
CTTGGGGGGATATCAGATTCCAGAGGCCAATTGTAGCAATTGAAATTTGCAGAATCAATTATGTAAATCTGAGACAAATTAGTATTAAAA
TTACACGGAGTATATTTTTTAAATCACCCAACTTTGTAGATTATACCTATTTTGGGCAGGTATGGAAAAATTTTGCAGTTAAATGATTGC
CTAAAGAAAGTGGTAAACAGGTGAGGAAAGATGGCCTCTGATCTAGGATAGATCCAGAACCACAAAGCATCTGCACCACAAAAGGTGTTA
GACTACCAAGCAGCTCCTGGTTTTCTGCATAGTATTAGTAGCACAGCTTAGGATGAGAATCCTTTCTCCAGTAACATTCTTAAAATAGCA
TGAAAAACAACGCAAAACTCAAATTTCTATTAAAACACACAAACTAAAATCAAGTGATTCTTTTTTGTAGATTAGGGAGAAGGACTGAAT
ATCTAATTTAAGAGAAGGAATAGTGTTTAAGTGTTATAGTGTGTGAGCTAATACCTTCTAAAGGAAAGACATGGCATGAAGATTGTGCAT
ACTTACAATGCTAAGGAAAAATCAAGAAAAGGACTGTGTGAGGCTCTGCTACTAGATGAAGTTGGAAGGACTATTAATGTGCTTCTTGAA
GTATCAAAAATGAAAAGAAAATTAAAATTGTTTAAGCCTGACAGGGAAGGATGTAAATACAAGTTTTTCTAGAGCTCTCTAACCTTTATT
TCAAAACTGGAATTATTCATCCATCTGTAATTGTTGATAATTTAACTAGTATATGTAGTTCATAAGGTAATAGAAAAGGTGATCATGAAA
GCATGTATATAACTGGACAGAACCACGATAATGCTATAAGATGTAGATTTAGTTAGGTTATCAGATGTTAAATGATTTTAATATTATTAA
ATAAATCAAACTAGAAAACTAACCACAAGTATAATGTAACAAAGTTAAATGCAGGATATAAAAATGTAGGATGGATTTTGCATAGTAAAA
AGATAAGTTTGCCATTTAAAATTGTTGTTTGTTGGGTTTAGCTGAAAGTAGGCATATATGGTTCCACTTGGGAAAACTTGCTTTAAAGCA
TTACAATGAACAATTTTTTCTCATTCTCTTATTCCTTTATCACTTTTTAAATGTAAAGAAAATTGTATTTATTTATTTTTTTAAATAAAC
ACCACCTTGCAGAATTTAATAGGCAAACATGTTACATATGACTAAGTAAGGGTCTTCAAGATGAAGTAAAGAAAATGTAAATGTTCTATT
ACCTTATGCAGAGACAAAAAAAAAAAGGAGTGGTGTCATTTAGCTAGCAAACAAACAAAATACAGTTAATTGGTGATATGTCCTTTCTTT
TCTCACTATGCCCTCTTGCCTCCAAAAATGACAACAAAGAATCACAATTTTTCTGATAAATAAATGCTAAACCAAGCGTTTCAAACTATT
GCATTGCCATTCTTTTGGACTTTAGTTATTAGAATGATGATTGTTATAGGGCAAATGAGAAATCCATGTGCATCAGCTTCTAGTTGTTAA
AAAAACCAGATAAATTAACTTCTACTGTATACTGTGGGCAGAGGATCCTAGAGCTGATCCTACAACATCAGCTTCTAGTTGTTAAAAAAA
AAAAAAGAAACAGATAAATTAACTTCTACTGTATATACTGTGGGCAGAGGATCTTACTGTGCCTCTGTTTGTGTACATGGACTTCGGTGT
GTATCAGTTTGAAGGACAGCCTTGCCCCATGTAAACATATAAATGCAGATTGGTATCGCCTGGTTGCTATTTGCTTAAGAACAAATATTA
TACAGATGAGATCAGGCATAATTTTAAAAGATCATTATCAGTGGAGACCTCATTATTACTGATATTACAATGGGGCCAGTTTTTATACTT
CTGGGTAGAATTAATAAAATTTTTCTGATCCCAGAGATCTGAGTTCTCTCTGCAGTTGGAAACAAGAAGCTGTTGTGGGCATTGTGTCGG
GCCAGGGGCCCTTGTGTTTGTGTGGGCAAATATCTTTTAGCAGTGTGAGCTGCTTTTTTCTTTTCATTAAAAGTCTCTCTAAAATAATAG
AAATTTCAGATACTCGGTTCAAGTCTCACTGATTTTGTAGAGGTCCAAAAATGTAGGATCTGTCACTTTTGCAGGCCCCTGCCTCACCTA
ATTCCTGGCCAGGTGACATTTTGGGCAGAAGTAAATGCTTCTATAGTCACAAGCTAAAATGACTCTAAGCCCCAATTTCACGGGGGGTAT
TCACATGCTTCCTCTGGAAAATACTCTTTGACAGTCAGCTTTGCAAGTAAGTGATTACCTTGTTAGGAATCAAAGAAAAATGTATTTCTC
TCTGACCTTTAGAGGAAAATAGAATCCTTCCCTTTTTTGCCCATTGACACAACTGGCACTGCTCTCTTCCCTTTCTACCACCCTGGTTCA
AAGTAGTCCCCCGATGCTGTCCTGTTCCTTTCTTAAGCCATAGTGGATCTCTGAGATCCTACACCCCACTTTGTGAAACACTGACTTCAT
CTTTGCCCTCGAATGCCTGATTTTTTCATAAGAGATTCTAGCAATTTGGACACTGTTTAAGTGAACTATCAAACTACCGCATAGAGAATA
TTTAAGCTATTAAAATTATGGTTTCCCATGAAGATCAATTCTCTGTGTCCTTCCCTATAGGAATTTGAGACGAGTTAGCCCTGTGATGAA
TCTTGAAACTCACATATGTCCACATACACTTGGTAGAACTTCGATTTAATCTTTACATAAAAGCTGTACATATAACCAAGAAGTTATTTT
TGCCAGTAAATTAACTTATTTGCTTTATTCATCTTATTTGGTTCCTAATCGTAAATATTTTGTAGCTGCTGTAAATTTTTTTCTCCCAAA
TGAGGAGTCTTATTATCATAAAGGTAAAGGCTATTCAGCTTTGATAACCACCTGCAATTCTTTTTTGGATCATTCATCCATCTAACAAAT
ACATAATGAGGACAGTTCATGTTAATGAAAATCCATGTTGTTTAATAGAATGCCATCCTTTACCTACTTTTGCTCTTTATGGACGTTTTT
CTTTTCATGCTCTAGTGAGCTTTCCCTATATCATGAGAAGTGGTTATATTTGTGCAAATATACAAATATAGGAAAACAAAGATTCATACC
TGTAGGCAATAGTCTAACTTGTCCAAACCACTTTGCCTTTACTGCTATTTTTATCCCCAATGCGTAGATATTTCCCCCAGGCCTATAGCC
TTTGTGAAGGAAAGCAAATCATACCTCCTGTATATTGACACGAATCTGGTTTTCAAATGTCATTTCCAGATTTTTTAGTTAATTGGGGGT
TGTCCTTTTCCCTTAATGTGAGAGTCATTTTCCTGTATATTTCTGGATCTCTCAGGGGCTGGGAGGGGGGAGTGAGGGGACTACAACCAT
AGCACTCCAAGAACCCTTTTGGGATTACTCCAGTAATCAACTACGAAAGTTATTTTCTAAATGTAGATATGTAAGGTGTTCTTTTAAAGT
AAGGTACTTTGAAATATGTAGCATAAACTGGTACTGCTGTTAAATGGGTCGATTATTAAACGGAGCAGCTGTGTGAGGGCAGCTAACTTT
GAATGCCTGTCTCCCTGGCTGGTGTGTCTCCTTCTCATGTTGAGAGCACCAGGGATTGCGTGGCTGCATGCTGAAACCGCATTTTCCCAT
GGTGTATGACTAGTTCATCTCTTTCTTGAGCACCATTACAAGAAGATCAAATGAAAATGAGATCAATGTGGAAGACAATTCATAGCACAA
AAAAAGTCATCTTAAATCTACTCTCAAACATTCATCTTATACATGCATCAAAGTAATTTACTGACATCAGTTTGGGTGAGAGAGGGAGTC
ACTTTACTGAAAAGGCAGAGGCTTAAGGTGTATACATTTGTACTCACTTCCTTATTTTCTTAACTTGTAAGCAGAAAACAAGCCCTCTCT
CTTGTGAAGTATCTTCAAAGGATTGGGGTGCAAAAATACCTTGCTGGTAAGCCATCAATGTTTTATTTAAATCCCTGCATTCAAAGTTAG
CTGCCTTTTTGAAATAAACAAACAAAAAATACTACTGTATGTTTGAAAATGTGAATAGTATTTTTATAGCTTGTTAAAGACATGGCTAGT
TGCATTTGTAAATAAGTATAATGTTGCTTTGATTTTCTTTTGTGGACATCTTTATTTGGAACATAATTGTCTTTAGGGTTGATTTGTATA
TAAGTAATTGGCCTGTGATTGTTTCTTTTTTGGTTGGAAGTTATCATTTTGACATTACTTGTGATTCTGTGTTCAGCACTATTGTGATGT
GTTCAACCTCTGCACTCGCTTACACAATAGGATATGCCAATTGTGTGTGGTGTAATGTTATTTTGATTTTTTTCCATGTTATTGATGAAG
GATCATGCACCTAACACATACTAACTTTTTTAATGTTAGGCATATTTTTAGTATACTTTCTCTTATTCTTTCTTCTCCTCCAACCTTTTA
CCCATCCTCCTTCCTTTCCCTCATTCCTGTTGTTATTTGAGAATGAGGGAGAAACAGTATTTTACATTTATGTAATTAGGCTTTTCCGTT
AGTTCTCAAGGATCCTCTTTTGGCTCTTGGGAAAGAATTGTACCTGTACAAGGCAATTATAGAATGCGAACTGCTTTGCCTCATTCCATA
CTGATCATCCCAGCTGAACAATTTGAAAACTGTTCTGCCTTTTTGTTACATGAATCTGTCAGAAATATATTTTTAATTTAATATAAATGA

>13417_13417_1_CBR4-ERBB4_CBR4_chr4_169923222_ENST00000306193_ERBB4_chr2_212989628_ENST00000342788_length(amino acids)=1477AA_BP=196
MERGSHSLPSFLRVCDSEMDKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHDVQNTFEELEK
HLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRAL
AKEVARKKIRVNVVAPVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLEN
LRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHK
SCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNA
KYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVT
GIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYIT
DNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSI
CVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGH
STLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGT
VYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLL
NWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIW
ELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDS
KFFQNLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVPYRAPTSTIPEA
PVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQ
ALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQN

--------------------------------------------------------------
>13417_13417_2_CBR4-ERBB4_CBR4_chr4_169923222_ENST00000306193_ERBB4_chr2_212989628_ENST00000402597_length(transcript)=4519nt_BP=704nt
ATTACTATTGTGCGGCTGCAGGAGGTGTCGAGCGGCGTTATTTTTTTTTGCGGTTTGCCTTTTTTTTTCTTTTTTTTTTTTTTGGAACCG
CGGTTGTTTAAAAGCCTGAGGGAACCTGGAGAGGGGCTCCCACTCCCTACCCTCTTTCCTCCGAGTTTGTGACTCCGAGATGGACAAAGT
GTGTGCTGTTTTTGGAGGCTCCCGAGGCATTGGCAGAGCTGTGGCCCAGTTAATGGCCCGGAAAGGCTACCGACTGGCGGTCATTGCCAG
AAACCTGGAAGGGGCCAAAGCCGCCGCCGGTGACCTCGGCGGAGATCATTTGGCATTTAGCTGTGATGTTGCTAAAGAACATGATGTTCA
AAATACATTTGAAGAGCTGGAGAAACATTTAGGTCGAGTAAATTTCTTGGTAAATGCAGCTGGTATTAACAGGGATGGTCTTTTAGTAAG
AACAAAAACTGAAGATATGGTATCTCAGCTTCATACTAACCTCTTGGGTTCCATGCTGACCTGTAAAGCTGCCATGAGGACTATGATTCA
ACAACAGGGAGGGTCTATTGTTAATGTAGGAAGCATTGTTGGCTTAAAAGGCAACTCTGGCCAGTCCGTTTACAGTGCCAGTAAAGGAGG
ATTAGTTGGATTTTCACGTGCTCTTGCTAAAGAGGTAGCAAGAAAGAAAATTAGAGTGAATGTAGTTGCACCAGTGTGTGCAGGAACGGA
GAATAAACTGAGCTCTCTCTCTGACCTGGAACAGCAGTACCGAGCCTTGCGCAAGTACTATGAAAACTGTGAGGTTGTCATGGGCAACCT
GGAGATAACCAGCATTGAGCACAACCGGGACCTCTCCTTCCTGCGGTCTGTTCGAGAAGTCACAGGCTACGTGTTAGTGGCTCTTAATCA
GTTTCGTTACCTGCCTCTGGAGAATTTACGCATTATTCGTGGGACAAAACTTTATGAGGATCGATATGCCTTGGCAATATTTTTAAACTA
CAGAAAAGATGGAAACTTTGGACTTCAAGAACTTGGATTAAAGAACTTGACAGAAATCCTAAATGGTGGAGTCTATGTAGACCAGAACAA
ATTCCTTTGTTATGCAGACACCATTCATTGGCAAGATATTGTTCGGAACCCATGGCCTTCCAACTTGACTCTTGTGTCAACAAATGGTAG
TTCAGGATGTGGACGTTGCCATAAGTCCTGTACTGGCCGTTGCTGGGGACCCACAGAAAATCATTGCCAGACTTTGACAAGGACGGTGTG
TGCAGAACAATGTGACGGCAGATGCTACGGACCTTACGTCAGTGACTGCTGCCATCGAGAATGTGCTGGAGGCTGCTCAGGACCTAAGGA
CACAGACTGCTTTGCCTGCATGAATTTCAATGACAGTGGAGCATGTGTTACTCAGTGTCCCCAAACCTTTGTCTACAATCCAACCACCTT
TCAACTGGAGCACAATTTCAATGCAAAGTACACATATGGAGCATTCTGTGTCAAGAAATGTCCACATAACTTTGTGGTAGATTCCAGTTC
TTGTGTGCGTGCCTGCCCTAGTTCCAAGATGGAAGTAGAAGAAAATGGGATTAAAATGTGTAAACCTTGCACTGACATTTGCCCAAAAGC
TTGTGATGGCATTGGCACAGGATCATTGATGTCAGCTCAGACTGTGGATTCCAGTAACATTGACAAATTCATAAACTGTACCAAGATCAA
TGGGAATTTGATCTTTCTAGTCACTGGTATTCATGGGGACCCTTACAATGCAATTGAAGCCATAGACCCAGAGAAACTGAACGTCTTTCG
GACAGTCAGAGAGATAACAGGTTTCCTGAACATACAGTCATGGCCACCAAACATGACTGACTTCAGTGTTTTTTCTAACCTGGTGACCAT
TGGTGGAAGAGTACTCTATAGTGGCCTGTCCTTGCTTATCCTCAAGCAACAGGGCATCACCTCTCTACAGTTCCAGTCCCTGAAGGAAAT
CAGCGCAGGAAACATCTATATTACTGACAACAGCAACCTGTGTTATTATCATACCATTAACTGGACAACACTCTTCAGCACAATCAACCA
GAGAATAGTAATCCGGGACAACAGAAAAGCTGAAAATTGTACTGCTGAAGGAATGGTGTGCAACCATCTGTGTTCCAGTGATGGCTGTTG
GGGACCTGGGCCAGACCAATGTCTGTCGTGTCGCCGCTTCAGTAGAGGAAGGATCTGCATAGAGTCTTGTAACCTCTATGATGGTGAATT
TCGGGAGTTTGAGAATGGCTCCATCTGTGTGGAGTGTGACCCCCAGTGTGAGAAGATGGAAGATGGCCTCCTCACATGCCATGGACCGGG
TCCTGACAACTGTACAAAGTGCTCTCATTTTAAAGATGGCCCAAACTGTGTGGAAAAATGTCCAGATGGCTTACAGGGGGCAAACAGTTT
CATTTTCAAGTATGCTGATCCAGATCGGGAGTGCCACCCATGCCATCCAAACTGCACCCAAGGGTGCATAGGCTCAAGTATTGAAGACTG
CATCGGCCTGATGGATAGAACTCCCCTGATTGCAGCTGGAGTAATTGGTGGGCTCTTCATTCTGGTCATTGTGGGTCTGACATTTGCTGT
TTATGTTAGAAGGAAGAGCATCAAAAAGAAAAGAGCCTTGAGAAGATTCTTGGAAACAGAGTTGGTGGAACCATTAACTCCCAGTGGCAC
AGCACCCAATCAAGCTCAACTTCGTATTTTGAAAGAAACTGAGCTGAAGAGGGTAAAAGTCCTTGGCTCAGGTGCTTTTGGAACGGTTTA
TAAAGGTATTTGGGTACCTGAAGGAGAAACTGTGAAGATTCCTGTGGCTATTAAGATTCTTAATGAGACAACTGGTCCCAAGGCAAATGT
GGAGTTCATGGATGAAGCTCTGATCATGGCAAGTATGGATCATCCACACCTAGTCCGGTTGCTGGGTGTGTGTCTGAGCCCAACCATCCA
GCTGGTTACTCAACTTATGCCCCATGGCTGCCTGTTGGAGTATGTCCACGAGCACAAGGATAACATTGGATCACAACTGCTGCTTAACTG
GTGTGTCCAGATAGCTAAGGGAATGATGTACCTGGAAGAAAGACGACTCGTTCATCGGGATTTGGCAGCCCGTAATGTCTTAGTGAAATC
TCCAAACCATGTGAAAATCACAGATTTTGGGCTAGCCAGACTCTTGGAAGGAGATGAAAAAGAGTACAATGCTGATGGAGGAAAGATGCC
AATTAAATGGATGGCTCTGGAGTGTATACATTACAGGAAATTCACCCATCAGAGTGACGTTTGGAGCTATGGAGTTACTATATGGGAACT
GATGACCTTTGGAGGAAAACCCTATGATGGAATTCCAACGCGAGAAATCCCTGATTTATTAGAGAAAGGAGAACGTTTGCCTCAGCCTCC
CATCTGCACTATTGACGTTTACATGGTCATGGTCAAATGTTGGATGATTGATGCTGACAGTAGACCTAAATTTAAGGAACTGGCTGCTGA
GTTTTCAAGGATGGCTCGAGACCCTCAAAGATACCTAGTTATTCAGGGTGATGATCGTATGAAGCTTCCCAGTCCAAATGACAGCAAGTT
CTTTCAGAATCTCTTGGATGAAGAGGATTTGGAAGATATGATGGATGCTGAGGAGTACTTGGTCCCTCAGGCTTTCAACATCCCACCTCC
CATCTATACTTCCAGAGCAAGAATTGACTCGAATAGGAGTGAAATTGGACACAGCCCTCCTCCTGCCTACACCCCCATGTCAGGAAACCA
GTTTGTATACCGAGATGGAGGTTTTGCTGCTGAACAAGGAGTGTCTGTGCCCTACAGAGCCCCAACTAGCACAATTCCAGAAGCTCCTGT
GGCACAGGGTGCTACTGCTGAGATTTTTGATGACTCCTGCTGTAATGGCACCCTACGCAAGCCAGTGGCACCCCATGTCCAAGAGGACAG
TAGCACCCAGAGGTACAGTGCTGACCCCACCGTGTTTGCCCCAGAACGGAGCCCACGAGGAGAGCTGGATGAGGAAGGTTACATGACTCC
TATGCGAGACAAACCCAAACAAGAATACCTGAATCCAGTGGAGGAGAACCCTTTTGTTTCTCGGAGAAAAAATGGAGACCTTCAAGCATT
GGATAATCCCGAATATCACAATGCATCCAATGGTCCACCCAAGGCCGAGGATGAGTATGTGAATGAGCCACTGTACCTCAACACCTTTGC
CAACACCTTGGGAAAAGCTGAGTACCTGAAGAACAACATACTGTCAATGCCAGAGAAGGCCAAGAAAGCGTTTGACAACCCTGACTACTG
GAACCACAGCCTGCCACCTCGGAGCACCCTTCAGCACCCAGACTACCTGCAGGAGTACAGCACAAAATATTTTTATAAACAGAATGGGCG
GATCCGGCCTATTGTGGCAGAGAATCCTGAATACCTCTCTGAGTTCTCCCTGAAGCCAGGCACTGTGCTGCCGCCTCCACCTTACAGACA

>13417_13417_2_CBR4-ERBB4_CBR4_chr4_169923222_ENST00000306193_ERBB4_chr2_212989628_ENST00000402597_length(amino acids)=1468AA_BP=196
MERGSHSLPSFLRVCDSEMDKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHDVQNTFEELEK
HLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRAL
AKEVARKKIRVNVVAPVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLEN
LRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHK
SCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNA
KYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVT
GIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYIT
DNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSI
CVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCIGSSIEDCIGLMDRTP
LIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEG
ETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGM
MYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPY
DGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEE
DLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEI
FDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNA
SNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAEN

--------------------------------------------------------------
>13417_13417_3_CBR4-ERBB4_CBR4_chr4_169923222_ENST00000306193_ERBB4_chr2_212989628_ENST00000436443_length(transcript)=12395nt_BP=704nt
ATTACTATTGTGCGGCTGCAGGAGGTGTCGAGCGGCGTTATTTTTTTTTGCGGTTTGCCTTTTTTTTTCTTTTTTTTTTTTTTGGAACCG
CGGTTGTTTAAAAGCCTGAGGGAACCTGGAGAGGGGCTCCCACTCCCTACCCTCTTTCCTCCGAGTTTGTGACTCCGAGATGGACAAAGT
GTGTGCTGTTTTTGGAGGCTCCCGAGGCATTGGCAGAGCTGTGGCCCAGTTAATGGCCCGGAAAGGCTACCGACTGGCGGTCATTGCCAG
AAACCTGGAAGGGGCCAAAGCCGCCGCCGGTGACCTCGGCGGAGATCATTTGGCATTTAGCTGTGATGTTGCTAAAGAACATGATGTTCA
AAATACATTTGAAGAGCTGGAGAAACATTTAGGTCGAGTAAATTTCTTGGTAAATGCAGCTGGTATTAACAGGGATGGTCTTTTAGTAAG
AACAAAAACTGAAGATATGGTATCTCAGCTTCATACTAACCTCTTGGGTTCCATGCTGACCTGTAAAGCTGCCATGAGGACTATGATTCA
ACAACAGGGAGGGTCTATTGTTAATGTAGGAAGCATTGTTGGCTTAAAAGGCAACTCTGGCCAGTCCGTTTACAGTGCCAGTAAAGGAGG
ATTAGTTGGATTTTCACGTGCTCTTGCTAAAGAGGTAGCAAGAAAGAAAATTAGAGTGAATGTAGTTGCACCAGTGTGTGCAGGAACGGA
GAATAAACTGAGCTCTCTCTCTGACCTGGAACAGCAGTACCGAGCCTTGCGCAAGTACTATGAAAACTGTGAGGTTGTCATGGGCAACCT
GGAGATAACCAGCATTGAGCACAACCGGGACCTCTCCTTCCTGCGGTCTGTTCGAGAAGTCACAGGCTACGTGTTAGTGGCTCTTAATCA
GTTTCGTTACCTGCCTCTGGAGAATTTACGCATTATTCGTGGGACAAAACTTTATGAGGATCGATATGCCTTGGCAATATTTTTAAACTA
CAGAAAAGATGGAAACTTTGGACTTCAAGAACTTGGATTAAAGAACTTGACAGAAATCCTAAATGGTGGAGTCTATGTAGACCAGAACAA
ATTCCTTTGTTATGCAGACACCATTCATTGGCAAGATATTGTTCGGAACCCATGGCCTTCCAACTTGACTCTTGTGTCAACAAATGGTAG
TTCAGGATGTGGACGTTGCCATAAGTCCTGTACTGGCCGTTGCTGGGGACCCACAGAAAATCATTGCCAGACTTTGACAAGGACGGTGTG
TGCAGAACAATGTGACGGCAGATGCTACGGACCTTACGTCAGTGACTGCTGCCATCGAGAATGTGCTGGAGGCTGCTCAGGACCTAAGGA
CACAGACTGCTTTGCCTGCATGAATTTCAATGACAGTGGAGCATGTGTTACTCAGTGTCCCCAAACCTTTGTCTACAATCCAACCACCTT
TCAACTGGAGCACAATTTCAATGCAAAGTACACATATGGAGCATTCTGTGTCAAGAAATGTCCACATAACTTTGTGGTAGATTCCAGTTC
TTGTGTGCGTGCCTGCCCTAGTTCCAAGATGGAAGTAGAAGAAAATGGGATTAAAATGTGTAAACCTTGCACTGACATTTGCCCAAAAGC
TTGTGATGGCATTGGCACAGGATCATTGATGTCAGCTCAGACTGTGGATTCCAGTAACATTGACAAATTCATAAACTGTACCAAGATCAA
TGGGAATTTGATCTTTCTAGTCACTGGTATTCATGGGGACCCTTACAATGCAATTGAAGCCATAGACCCAGAGAAACTGAACGTCTTTCG
GACAGTCAGAGAGATAACAGGTTTCCTGAACATACAGTCATGGCCACCAAACATGACTGACTTCAGTGTTTTTTCTAACCTGGTGACCAT
TGGTGGAAGAGTACTCTATAGTGGCCTGTCCTTGCTTATCCTCAAGCAACAGGGCATCACCTCTCTACAGTTCCAGTCCCTGAAGGAAAT
CAGCGCAGGAAACATCTATATTACTGACAACAGCAACCTGTGTTATTATCATACCATTAACTGGACAACACTCTTCAGCACAATCAACCA
GAGAATAGTAATCCGGGACAACAGAAAAGCTGAAAATTGTACTGCTGAAGGAATGGTGTGCAACCATCTGTGTTCCAGTGATGGCTGTTG
GGGACCTGGGCCAGACCAATGTCTGTCGTGTCGCCGCTTCAGTAGAGGAAGGATCTGCATAGAGTCTTGTAACCTCTATGATGGTGAATT
TCGGGAGTTTGAGAATGGCTCCATCTGTGTGGAGTGTGACCCCCAGTGTGAGAAGATGGAAGATGGCCTCCTCACATGCCATGGACCGGG
TCCTGACAACTGTACAAAGTGCTCTCATTTTAAAGATGGCCCAAACTGTGTGGAAAAATGTCCAGATGGCTTACAGGGGGCAAACAGTTT
CATTTTCAAGTATGCTGATCCAGATCGGGAGTGCCACCCATGCCATCCAAACTGCACCCAAGGGTGTAACGGTCCCACTAGTCATGACTG
CATTTACTACCCATGGACGGGCCATTCCACTTTACCACAACATGCTAGAACTCCCCTGATTGCAGCTGGAGTAATTGGTGGGCTCTTCAT
TCTGGTCATTGTGGGTCTGACATTTGCTGTTTATGTTAGAAGGAAGAGCATCAAAAAGAAAAGAGCCTTGAGAAGATTCTTGGAAACAGA
GTTGGTGGAACCATTAACTCCCAGTGGCACAGCACCCAATCAAGCTCAACTTCGTATTTTGAAAGAAACTGAGCTGAAGAGGGTAAAAGT
CCTTGGCTCAGGTGCTTTTGGAACGGTTTATAAAGGTATTTGGGTACCTGAAGGAGAAACTGTGAAGATTCCTGTGGCTATTAAGATTCT
TAATGAGACAACTGGTCCCAAGGCAAATGTGGAGTTCATGGATGAAGCTCTGATCATGGCAAGTATGGATCATCCACACCTAGTCCGGTT
GCTGGGTGTGTGTCTGAGCCCAACCATCCAGCTGGTTACTCAACTTATGCCCCATGGCTGCCTGTTGGAGTATGTCCACGAGCACAAGGA
TAACATTGGATCACAACTGCTGCTTAACTGGTGTGTCCAGATAGCTAAGGGAATGATGTACCTGGAAGAAAGACGACTCGTTCATCGGGA
TTTGGCAGCCCGTAATGTCTTAGTGAAATCTCCAAACCATGTGAAAATCACAGATTTTGGGCTAGCCAGACTCTTGGAAGGAGATGAAAA
AGAGTACAATGCTGATGGAGGAAAGATGCCAATTAAATGGATGGCTCTGGAGTGTATACATTACAGGAAATTCACCCATCAGAGTGACGT
TTGGAGCTATGGAGTTACTATATGGGAACTGATGACCTTTGGAGGAAAACCCTATGATGGAATTCCAACGCGAGAAATCCCTGATTTATT
AGAGAAAGGAGAACGTTTGCCTCAGCCTCCCATCTGCACTATTGACGTTTACATGGTCATGGTCAAATGTTGGATGATTGATGCTGACAG
TAGACCTAAATTTAAGGAACTGGCTGCTGAGTTTTCAAGGATGGCTCGAGACCCTCAAAGATACCTAGTTATTCAGGGTGATGATCGTAT
GAAGCTTCCCAGTCCAAATGACAGCAAGTTCTTTCAGAATCTCTTGGATGAAGAGGATTTGGAAGATATGATGGATGCTGAGGAGTACTT
GGTCCCTCAGGCTTTCAACATCCCACCTCCCATCTATACTTCCAGAGCAAGAATTGACTCGAATAGGAACCAGTTTGTATACCGAGATGG
AGGTTTTGCTGCTGAACAAGGAGTGTCTGTGCCCTACAGAGCCCCAACTAGCACAATTCCAGAAGCTCCTGTGGCACAGGGTGCTACTGC
TGAGATTTTTGATGACTCCTGCTGTAATGGCACCCTACGCAAGCCAGTGGCACCCCATGTCCAAGAGGACAGTAGCACCCAGAGGTACAG
TGCTGACCCCACCGTGTTTGCCCCAGAACGGAGCCCACGAGGAGAGCTGGATGAGGAAGGTTACATGACTCCTATGCGAGACAAACCCAA
ACAAGAATACCTGAATCCAGTGGAGGAGAACCCTTTTGTTTCTCGGAGAAAAAATGGAGACCTTCAAGCATTGGATAATCCCGAATATCA
CAATGCATCCAATGGTCCACCCAAGGCCGAGGATGAGTATGTGAATGAGCCACTGTACCTCAACACCTTTGCCAACACCTTGGGAAAAGC
TGAGTACCTGAAGAACAACATACTGTCAATGCCAGAGAAGGCCAAGAAAGCGTTTGACAACCCTGACTACTGGAACCACAGCCTGCCACC
TCGGAGCACCCTTCAGCACCCAGACTACCTGCAGGAGTACAGCACAAAATATTTTTATAAACAGAATGGGCGGATCCGGCCTATTGTGGC
AGAGAATCCTGAATACCTCTCTGAGTTCTCCCTGAAGCCAGGCACTGTGCTGCCGCCTCCACCTTACAGACACCGGAATACTGTGGTGTA
AGCTCAGTTGTGGTTTTTTAGGTGGAGAGACACACCTGCTCCAATTTCCCCACCCCCCTCTCTTTCTCTGGTGGTCTTCCTTCTACCCCA
AGGCCAGTAGTTTTGACACTTCCCAGTGGAAGATACAGAGATGCAATGATAGTTATGTGCTTACCTAACTTGAACATTAGAGGGAAAGAC
TGAAAGAGAAAGATAGGAGGAACCACAATGTTTCTTCATTTCTCTGCATGGGTTGGTCAGGAGAATGAAACAGCTAGAGAAGGACCAGAA
AATGTAAGGCAATGCTGCCTACTATCAAACTAGCTGTCACTTTTTTTCTTTTTCTTTTTCTTTCTTTGTTTCTTTCTTCCTCTTCTTTTT
TTTTTTTTTTTTTAAAGCAGATGGTTGAAACACCCATGCTATCTGTTCCTATCTGCAGGAACTGATGTGTGCATATTTAGCATCCCTGGA
AATCATAATAAAGTTTCCATTAGAACAAAAGAATAACATTTTCTATAACATATGATGGTGTCTGAAATTGAGAATCCAGTTTCTTTCCCC
AGCAGTTTCTGTCCTAGCAAGTAAGAATGGCCAACTCAACTTTCATAATTTAAAAATCTCCATTAAAGTTATAACTAGTAATTATGTTTT
CAACACTTTTTGGTTTTTTTCATTTTGTTTTGCTCTGACCGATTCCTTTATATTTGCTCCCCTATTTTTGGCTTTAATTTCTAATTGCAA
AGATGTTTACATCAAAGCTTCTTCACAGAATTTAAGCAAGAAATATTTTAATATAGTGAAATGGCCACTACTTTAAGTATACAATCTTTA
AAATAAGAAAGGGAGGCTAATATTTTTCATGCTATCAAATTATCTTCACCCTCATCCTTTACATTTTTCAACATTTTTTTTTCTCCATAA
ATGACACTACTTGATAGGCCGTTGGTTGTCTGAAGAGTAGAAGGGAAACTAAGAGACAGTTCTCTGTGGTTCAGGAAAACTACTGATACT
TTCAGGGGTGGCCCAATGAGGGAATCCATTGAACTGGAAGAAACACACTGGATTGGGTATGTCTACCTGGCAGATACTCAGAAATGTAGT
TTGCACTTAAGCTGTAATTTTATTTGTTCTTTTTCTGAACTCCATTTTGGATTTTGAATCAAGCAATATGGAAGCAACCAGCAAATTAAC
TAATTTAAGTACATTTTTAAAAAAAGAGCTAAGATAAAGACTGTGGAAATGCCAAACCAAGCAAATTAGGAACCTTGCAACGGTATCCAG
GGACTATGATGAGAGGCCAGCACATTATCTTCATATGTCACCTTTGCTACGCAAGGAAATTTGTTCAGTTCGTATACTTCGTAAGAAGGA
ATGCGAGTAAGGATTGGCTTGAATTCCATGGAATTTCTAGTATGAGACTATTTATATGAAGTAGAAGGTAACTCTTTGCACATAAATTGG
TATAATAAAAAGAAAAACACAAACATTCAAAGCTTAGGGATAGGTCCTTGGGTCAAAAGTTGTAAATAAATGTGAAACATCTTCTCATGC
AATTATTTTATTATCCAACACACTAATCTTTTGATACTTTATATAATTCCCTTTCTTCATATACTGCATCCAGTACTAGAACCATCATTA
TTATGTATCATTTTGAAAGAATACCTGATGAGATGAAGGATGAGAACAAATGACAGAGATGAGTCTCCAAGTAAAGGGGGCCTCACATCA
ATAATTAGGAAACTTAGATATAAGTCGCCCTTTTCTGAAAATTCTACCCCAAGTCATTTAGATTTTTAAAAAATATTTCTAATGTTAAAA
TATTGGGACCAAATTAGAATCAATAGTATAAGATTAATTAATTAGAGTAAAAATATCTATTAAGGCAGAGAAAGTTTAGAGAAAAAAATC
CAAAGAAATTTGTGTTTCTTCCTATTCTGAACAAGTAAATCCATCCATCCATCCATCCAAACCTCCTTTATCTAACTGTGTCTACTAAAA
GCACCATGTTTTGTGGGGAACACTCAGATAAATGGAATATCATCCTCAACTTCAAAATTCTATGATCTAGGAGATTTAATTAAAATGACA
TTTTAATTTTTCTATGCGTTCCAACAATCAGATTGCATAGTCTCTTTTGTGAATAGCTGTCATATAATCAGTTGTACTGTAAGATATCTC
CTTTAAACTCATTTGGGATATAAGTTAAACATCCTTCAAATTGTTGATGTTGACAAACAGGATAATTTCAATAATATTATTCAAACATAA
ACTGGTCTAGGAGAATATTGCATCACTGACTAATTAGCCTATCTAGAGTCTAACTTCACCATTAAACCAAAAGCAGATGGTGGTCCTTGG
CCAAGAATATTGGAGACATTGGAGTTGGTTTTTTTCTAAGCTATAAGAAGTGAGGCGAGCTGAAAAAGTATGGTAGAGCAGGAGAAGGGT
TTGTGAGATTCCTTCTAGTGAAGTTCACCCTCAAACTTTTCAGGGGTAAAGACACAGAGTGATTCAGGGGCCACAATCTAATAGCTCAGG
GCTCTCCTATCCATTCAGAGAAGTCTCTAGGAAAAGGGATCTCATATCAGTACTTATGAAAAATTGAATATAAGCCTCCCTTTCTAAATA
AATCTGCATCGAGTCATCACAGCCCTCTTTTTGGATACTATACCTTGATTTTTTTTTTCTGATTTACAATATGCATATGGTTTCTACTGG
GCTATAGAAAGCAGAATCACTCATTTTGGAGAAGGAAAAAATGAATAGTTAAAACAAACTTTTAACTGTTAAGGTAACAGAAATGTATTT
AGTGAATGTCTCTTTCCTCCTAAGAACACAAGACTTCTACATGTTGGGTAATACCTAGAGATGCATGTAGGAATAATCCAAAATGACCCA
AATGCTTTATAATAGCACCACTTTATAATTCTTTTGAATGATTTCTGTAGTATATAATTGACTTCAGTTGTTTGAGTGTTTTTTGTTTTA
TTTTTGTCCCCCCTGGGAAAACATATTTCAGCATGTATAAGAGGGAGAAAAAAAGTTTCATTCCTTCCAGAGAATAACTTATTTAGTCCA
GTAGGGTAGAATTTTAAAATGTCAGTTAAAGTCTTCAAAGTGCTTGGGGGGATATCAGATTCCAGAGGCCAATTGTAGCAATTGAAATTT
GCAGAATCAATTATGTAAATCTGAGACAAATTAGTATTAAAATTACACGGAGTATATTTTTTAAATCACCCAACTTTGTAGATTATACCT
ATTTTGGGCAGGTATGGAAAAATTTTGCAGTTAAATGATTGCCTAAAGAAAGTGGTAAACAGGTGAGGAAAGATGGCCTCTGATCTAGGA
TAGATCCAGAACCACAAAGCATCTGCACCACAAAAGGTGTTAGACTACCAAGCAGCTCCTGGTTTTCTGCATAGTATTAGTAGCACAGCT
TAGGATGAGAATCCTTTCTCCAGTAACATTCTTAAAATAGCATGAAAAACAACGCAAAACTCAAATTTCTATTAAAACACACAAACTAAA
ATCAAGTGATTCTTTTTTGTAGATTAGGGAGAAGGACTGAATATCTAATTTAAGAGAAGGAATAGTGTTTAAGTGTTATAGTGTGTGAGC
TAATACCTTCTAAAGGAAAGACATGGCATGAAGATTGTGCATACTTACAATGCTAAGGAAAAATCAAGAAAAGGACTGTGTGAGGCTCTG
CTACTAGATGAAGTTGGAAGGACTATTAATGTGCTTCTTGAAGTATCAAAAATGAAAAGAAAATTAAAATTGTTTAAGCCTGACAGGGAA
GGATGTAAATACAAGTTTTTCTAGAGCTCTCTAACCTTTATTTCAAAACTGGAATTATTCATCCATCTGTAATTGTTGATAATTTAACTA
GTATATGTAGTTCATAAGGTAATAGAAAAGGTGATCATGAAAGCATGTATATAACTGGACAGAACCACGATAATGCTATAAGATGTAGAT
TTAGTTAGGTTATCAGATGTTAAATGATTTTAATATTATTAAATAAATCAAACTAGAAAACTAACCACAAGTATAATGTAACAAAGTTAA
ATGCAGGATATAAAAATGTAGGATGGATTTTGCATAGTAAAAAGATAAGTTTGCCATTTAAAATTGTTGTTTGTTGGGTTTAGCTGAAAG
TAGGCATATATGGTTCCACTTGGGAAAACTTGCTTTAAAGCATTACAATGAACAATTTTTTCTCATTCTCTTATTCCTTTATCACTTTTT
AAATGTAAAGAAAATTGTATTTATTTATTTTTTTAAATAAACACCACCTTGCAGAATTTAATAGGCAAACATGTTACATATGACTAAGTA
AGGGTCTTCAAGATGAAGTAAAGAAAATGTAAATGTTCTATTACCTTATGCAGAGACAAAAAAAAAAAGGAGTGGTGTCATTTAGCTAGC
AAACAAACAAAATACAGTTAATTGGTGATATGTCCTTTCTTTTCTCACTATGCCCTCTTGCCTCCAAAAATGACAACAAAGAATCACAAT
TTTTCTGATAAATAAATGCTAAACCAAGCGTTTCAAACTATTGCATTGCCATTCTTTTGGACTTTAGTTATTAGAATGATGATTGTTATA
GGGCAAATGAGAAATCCATGTGCATCAGCTTCTAGTTGTTAAAAAAACCAGATAAATTAACTTCTACTGTATACTGTGGGCAGAGGATCC
TAGAGCTGATCCTACAACATCAGCTTCTAGTTGTTAAAAAAAAAAAAAGAAACAGATAAATTAACTTCTACTGTATATACTGTGGGCAGA
GGATCTTACTGTGCCTCTGTTTGTGTACATGGACTTCGGTGTGTATCAGTTTGAAGGACAGCCTTGCCCCATGTAAACATATAAATGCAG
ATTGGTATCGCCTGGTTGCTATTTGCTTAAGAACAAATATTATACAGATGAGATCAGGCATAATTTTAAAAGATCATTATCAGTGGAGAC
CTCATTATTACTGATATTACAATGGGGCCAGTTTTTATACTTCTGGGTAGAATTAATAAAATTTTTCTGATCCCAGAGATCTGAGTTCTC
TCTGCAGTTGGAAACAAGAAGCTGTTGTGGGCATTGTGTCGGGCCAGGGGCCCTTGTGTTTGTGTGGGCAAATATCTTTTAGCAGTGTGA
GCTGCTTTTTTCTTTTCATTAAAAGTCTCTCTAAAATAATAGAAATTTCAGATACTCGGTTCAAGTCTCACTGATTTTGTAGAGGTCCAA
AAATGTAGGATCTGTCACTTTTGCAGGCCCCTGCCTCACCTAATTCCTGGCCAGGTGACATTTTGGGCAGAAGTAAATGCTTCTATAGTC
ACAAGCTAAAATGACTCTAAGCCCCAATTTCACGGGGGGTATTCACATGCTTCCTCTGGAAAATACTCTTTGACAGTCAGCTTTGCAAGT
AAGTGATTACCTTGTTAGGAATCAAAGAAAAATGTATTTCTCTCTGACCTTTAGAGGAAAATAGAATCCTTCCCTTTTTTGCCCATTGAC
ACAACTGGCACTGCTCTCTTCCCTTTCTACCACCCTGGTTCAAAGTAGTCCCCCGATGCTGTCCTGTTCCTTTCTTAAGCCATAGTGGAT
CTCTGAGATCCTACACCCCACTTTGTGAAACACTGACTTCATCTTTGCCCTCGAATGCCTGATTTTTTCATAAGAGATTCTAGCAATTTG
GACACTGTTTAAGTGAACTATCAAACTACCGCATAGAGAATATTTAAGCTATTAAAATTATGGTTTCCCATGAAGATCAATTCTCTGTGT
CCTTCCCTATAGGAATTTGAGACGAGTTAGCCCTGTGATGAATCTTGAAACTCACATATGTCCACATACACTTGGTAGAACTTCGATTTA
ATCTTTACATAAAAGCTGTACATATAACCAAGAAGTTATTTTTGCCAGTAAATTAACTTATTTGCTTTATTCATCTTATTTGGTTCCTAA
TCGTAAATATTTTGTAGCTGCTGTAAATTTTTTTCTCCCAAATGAGGAGTCTTATTATCATAAAGGTAAAGGCTATTCAGCTTTGATAAC
CACCTGCAATTCTTTTTTGGATCATTCATCCATCTAACAAATACATAATGAGGACAGTTCATGTTAATGAAAATCCATGTTGTTTAATAG
AATGCCATCCTTTACCTACTTTTGCTCTTTATGGACGTTTTTCTTTTCATGCTCTAGTGAGCTTTCCCTATATCATGAGAAGTGGTTATA
TTTGTGCAAATATACAAATATAGGAAAACAAAGATTCATACCTGTAGGCAATAGTCTAACTTGTCCAAACCACTTTGCCTTTACTGCTAT
TTTTATCCCCAATGCGTAGATATTTCCCCCAGGCCTATAGCCTTTGTGAAGGAAAGCAAATCATACCTCCTGTATATTGACACGAATCTG
GTTTTCAAATGTCATTTCCAGATTTTTTAGTTAATTGGGGGTTGTCCTTTTCCCTTAATGTGAGAGTCATTTTCCTGTATATTTCTGGAT
CTCTCAGGGGCTGGGAGGGGGGAGTGAGGGGACTACAACCATAGCACTCCAAGAACCCTTTTGGGATTACTCCAGTAATCAACTACGAAA
GTTATTTTCTAAATGTAGATATGTAAGGTGTTCTTTTAAAGTAAGGTACTTTGAAATATGTAGCATAAACTGGTACTGCTGTTAAATGGG
TCGATTATTAAACGGAGCAGCTGTGTGAGGGCAGCTAACTTTGAATGCCTGTCTCCCTGGCTGGTGTGTCTCCTTCTCATGTTGAGAGCA
CCAGGGATTGCGTGGCTGCATGCTGAAACCGCATTTTCCCATGGTGTATGACTAGTTCATCTCTTTCTTGAGCACCATTACAAGAAGATC
AAATGAAAATGAGATCAATGTGGAAGACAATTCATAGCACAAAAAAAGTCATCTTAAATCTACTCTCAAACATTCATCTTATACATGCAT
CAAAGTAATTTACTGACATCAGTTTGGGTGAGAGAGGGAGTCACTTTACTGAAAAGGCAGAGGCTTAAGGTGTATACATTTGTACTCACT
TCCTTATTTTCTTAACTTGTAAGCAGAAAACAAGCCCTCTCTCTTGTGAAGTATCTTCAAAGGATTGGGGTGCAAAAATACCTTGCTGGT
AAGCCATCAATGTTTTATTTAAATCCCTGCATTCAAAGTTAGCTGCCTTTTTGAAATAAACAAACAAAAAATACTACTGTATGTTTGAAA
ATGTGAATAGTATTTTTATAGCTTGTTAAAGACATGGCTAGTTGCATTTGTAAATAAGTATAATGTTGCTTTGATTTTCTTTTGTGGACA
TCTTTATTTGGAACATAATTGTCTTTAGGGTTGATTTGTATATAAGTAATTGGCCTGTGATTGTTTCTTTTTTGGTTGGAAGTTATCATT
TTGACATTACTTGTGATTCTGTGTTCAGCACTATTGTGATGTGTTCAACCTCTGCACTCGCTTACACAATAGGATATGCCAATTGTGTGT
GGTGTAATGTTATTTTGATTTTTTTCCATGTTATTGATGAAGGATCATGCACCTAACACATACTAACTTTTTTAATGTTAGGCATATTTT
TAGTATACTTTCTCTTATTCTTTCTTCTCCTCCAACCTTTTACCCATCCTCCTTCCTTTCCCTCATTCCTGTTGTTATTTGAGAATGAGG
GAGAAACAGTATTTTACATTTATGTAATTAGGCTTTTCCGTTAGTTCTCAAGGATCCTCTTTTGGCTCTTGGGAAAGAATTGTACCTGTA
CAAGGCAATTATAGAATGCGAACTGCTTTGCCTCATTCCATACTGATCATCCCAGCTGAACAATTTGAAAACTGTTCTGCCTTTTTGTTA

>13417_13417_3_CBR4-ERBB4_CBR4_chr4_169923222_ENST00000306193_ERBB4_chr2_212989628_ENST00000436443_length(amino acids)=1461AA_BP=196
MERGSHSLPSFLRVCDSEMDKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHDVQNTFEELEK
HLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRAL
AKEVARKKIRVNVVAPVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLEN
LRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHK
SCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNA
KYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVT
GIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYIT
DNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSI
CVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGH
STLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGT
VYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLL
NWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIW
ELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDS
KFFQNLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCC
NGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPK
AEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSE

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Fusion Gene PPI Analysis for CBR4-ERBB4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CBR4-ERBB4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneERBB4Q15303DB08916AfatinibInhibitorSmall moleculeApproved
TgeneERBB4Q15303DB08916AfatinibInhibitorSmall moleculeApproved
TgeneERBB4Q15303DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
TgeneERBB4Q15303DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
TgeneERBB4Q15303DB12267BrigatinibInhibitorSmall moleculeApproved|Investigational
TgeneERBB4Q15303DB12267BrigatinibInhibitorSmall moleculeApproved|Investigational
TgeneERBB4Q15303DB15035ZanubrutinibInhibitorSmall moleculeApproved|Investigational
TgeneERBB4Q15303DB15035ZanubrutinibInhibitorSmall moleculeApproved|Investigational

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Related Diseases for CBR4-ERBB4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0005586Bipolar Disorder5PSYGENET
TgeneC0036341Schizophrenia4PSYGENET
TgeneC0004238Atrial Fibrillation2CTD_human
TgeneC0235480Paroxysmal atrial fibrillation2CTD_human
TgeneC2585653Persistent atrial fibrillation2CTD_human
TgeneC3468561familial atrial fibrillation2CTD_human
TgeneC0002736Amyotrophic Lateral Sclerosis1ORPHANET
TgeneC0007114Malignant neoplasm of skin1CTD_human
TgeneC0016978gallbladder neoplasm1CTD_human
TgeneC0025202melanoma1CGI;CTD_human
TgeneC0037286Skin Neoplasms1CTD_human
TgeneC0153452Malignant neoplasm of gallbladder1CTD_human
TgeneC3715155AMYOTROPHIC LATERAL SCLEROSIS 191CTD_human;GENOMICS_ENGLAND;UNIPROT