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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:MIGA2-P4HB (FusionGDB2 ID:HG84895TG5034)

Fusion Gene Summary for MIGA2-P4HB

check button Fusion gene summary
Fusion gene informationFusion gene name: MIGA2-P4HB
Fusion gene ID: hg84895tg5034
HgeneTgene
Gene symbol

MIGA2

P4HB

Gene ID

84895

5034

Gene namemitoguardin 2prolyl 4-hydroxylase subunit beta
SynonymsC9orf54|FAM73BCLCRP1|DSI|ERBA2L|GIT|P4Hbeta|PDI|PDIA1|PHDB|PO4DB|PO4HB|PROHB
Cytomap('FAM73B','MIGA2')('P4HB','P4HB')

9q34.11

17q25.3

Type of geneprotein-codingprotein-coding
Descriptionmitoguardin 2family with sequence similarity 73, member Bprotein FAM73Bprotein disulfide-isomerasecellular thyroid hormone-binding proteincollagen prolyl 4-hydroxylase betaglutathione-insulin transhydrogenasep55procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptideprolyl 4-hydroxyla
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000277475, ENST00000358369, 
ENST00000406926, ENST00000474534, 
Fusion gene scores* DoF score3 X 4 X 4=4818 X 16 X 10=2880
# samples 421
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/2880*10)=-3.77760757866355
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MIGA2 [Title/Abstract] AND P4HB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFAM73B(131825910)-P4HB(79805223), # samples:2
MIGA2(131825910)-P4HB(79805223), # samples:1
Anticipated loss of major functional domain due to fusion event.FAM73B-P4HB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FAM73B-P4HB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FAM73B-P4HB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FAM73B-P4HB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMIGA2

GO:0008053

mitochondrial fusion

26711011

TgeneP4HB

GO:0018401

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

7753822


check buttonFusion gene breakpoints across FAM73B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across P4HB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-N9-A4PZ-01AFAM73Bchr9

131825910

-P4HBchr17

79805223

-
ChimerDB4UCSTCGA-N9-A4PZFAM73Bchr9

131825910

+P4HBchr17

79805223

-
ChimerDB4UCSTCGA-N9-A4PZ-01AMIGA2chr9

131825910

+P4HBchr17

79805223

-


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Fusion Gene ORF analysis for MIGA2-P4HB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000277475ENST00000331483FAM73Bchr9

131825910

+P4HBchr17

79805223

-
3UTR-5UTRENST00000277475ENST00000472244FAM73Bchr9

131825910

+P4HBchr17

79805223

-
3UTR-intronENST00000277475ENST00000439918FAM73Bchr9

131825910

+P4HBchr17

79805223

-
3UTR-intronENST00000277475ENST00000576390FAM73Bchr9

131825910

+P4HBchr17

79805223

-
5CDS-5UTRENST00000358369ENST00000472244FAM73Bchr9

131825910

+P4HBchr17

79805223

-
5CDS-intronENST00000358369ENST00000439918FAM73Bchr9

131825910

+P4HBchr17

79805223

-
5CDS-intronENST00000358369ENST00000576390FAM73Bchr9

131825910

+P4HBchr17

79805223

-
In-frameENST00000358369ENST00000331483FAM73Bchr9

131825910

+P4HBchr17

79805223

-
intron-3CDSENST00000406926ENST00000331483FAM73Bchr9

131825910

+P4HBchr17

79805223

-
intron-3CDSENST00000474534ENST00000331483FAM73Bchr9

131825910

+P4HBchr17

79805223

-
intron-5UTRENST00000406926ENST00000472244FAM73Bchr9

131825910

+P4HBchr17

79805223

-
intron-5UTRENST00000474534ENST00000472244FAM73Bchr9

131825910

+P4HBchr17

79805223

-
intron-intronENST00000406926ENST00000439918FAM73Bchr9

131825910

+P4HBchr17

79805223

-
intron-intronENST00000406926ENST00000576390FAM73Bchr9

131825910

+P4HBchr17

79805223

-
intron-intronENST00000474534ENST00000439918FAM73Bchr9

131825910

+P4HBchr17

79805223

-
intron-intronENST00000474534ENST00000576390FAM73Bchr9

131825910

+P4HBchr17

79805223

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358369FAM73Bchr9131825910+ENST00000331483P4HBchr1779805223-31521396342298754

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358369ENST00000331483FAM73Bchr9131825910+P4HBchr1779805223-0.0095481970.9904518

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Fusion Genomic Features for MIGA2-P4HB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for MIGA2-P4HB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:131825910/:79805223)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAM73Bchr9:131825910chr17:79805223ENST00000277475+1217105_148430792.6666666666666Compositional biasNote=Ser-rich
HgeneFAM73Bchr9:131825910chr17:79805223ENST00000277475+121767_71430792.6666666666666Compositional biasNote=Poly-Arg
HgeneFAM73Bchr9:131825910chr17:79805223ENST00000358369+1116105_148390594.0Compositional biasNote=Ser-rich
HgeneFAM73Bchr9:131825910chr17:79805223ENST00000358369+111667_71390594.0Compositional biasNote=Poly-Arg
HgeneFAM73Bchr9:131825910chr17:79805223ENST00000277475+121711_31430792.6666666666666TransmembraneHelical
HgeneFAM73Bchr9:131825910chr17:79805223ENST00000277475+121742_62430792.6666666666666TransmembraneHelical
HgeneFAM73Bchr9:131825910chr17:79805223ENST00000358369+111611_31390594.0TransmembraneHelical
HgeneFAM73Bchr9:131825910chr17:79805223ENST00000358369+111642_62390594.0TransmembraneHelical
TgeneP4HBchr9:131825910chr17:79805223ENST00000331483311349_475208509.0DomainThioredoxin 2
TgeneP4HBchr9:131825910chr17:79805223ENST00000331483311505_508208509.0MotifNote=Prevents secretion from ER

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAM73Bchr9:131825910chr17:79805223ENST00000406926+114105_1480858.3333333333334Compositional biasNote=Ser-rich
HgeneFAM73Bchr9:131825910chr17:79805223ENST00000406926+11467_710858.3333333333334Compositional biasNote=Poly-Arg
HgeneFAM73Bchr9:131825910chr17:79805223ENST00000406926+11411_310858.3333333333334TransmembraneHelical
HgeneFAM73Bchr9:131825910chr17:79805223ENST00000406926+11442_620858.3333333333334TransmembraneHelical
TgeneP4HBchr9:131825910chr17:79805223ENST0000033148331118_134208509.0DomainThioredoxin 1


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Fusion Gene Sequence for MIGA2-P4HB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>29194_29194_1_FAM73B-P4HB_FAM73B_chr9_131825910_ENST00000358369_P4HB_chr17_79805223_ENST00000331483_length(transcript)=3152nt_BP=1396nt
AGGTACCCGATCCGAGGCGGGGAGAGCACCCGGGATGGAAGGAGCAGGCGTGCGGGCCGTGAGCGGCGCCAGAGGGTACCTGGCTCTGTG
GAGGGGCCCTCTGGTATGTGTGTCCCTGTCCTTCTGGGGCGTGGATGGTGCCTGGGACCCAGCTGGCAACCAGTTGAAGACGTTCTCCTT
GGAAGCTCTTGGCCCTGAGGACTTTGCCTGGGGCATTGGCCCTGCCATGGCGTTCCGGAGGGCCGAGGGCACGTCTATGATCCAGGCCCT
GGCCATGACGGTGGCCGAGATCCCCGTGTTCCTGTACACGACGTTTGGGCAGTCTGCATTCTCCCAGCTACGGTTGACGCCAGGCCTGCG
GAAAGTCCTCTTTGCCACGGCCCTGGGGACTGTGGCCCTGGCCCTGGCTGCCCACCAGCTGAAGAGGCGACGGAGGAGGAAGAAGCAGGT
TGGTCCCGAGATGGGAGGGGAGCAGCTGGGCACGGTGCCCCTCCCTATCCTCTTGGCCAGGAAGGTCCCTTCAGTGAAGAAAGGATACTC
CAGCCGGAGAGTCCAGAGCCCCAGCAGCAAGAGCAACGACACCCTGAGTGGCATCTCTTCCATTGAGCCCAGCAAGCACTCGGGCTCCTC
CCACAGTGTGGCCTCGATGATGGCAGTGAACTCATCCAGCCCCACAGCCGCGTGCTCGGGACTATGGGATGCCAGAGGGATGGAGGAGTC
TCTGACCACCAGCGACGGCAATGCAGAGAGCCTGTACATGCAAGGCATGGAGCTGTTTGAGGAAGCTCTGCAGAAGTGGGAGCAGGCACT
AAGCGTGGGCCAGCGGGGGGACAGCGGCAGCACCCCCATGCCCAGGGACGGCCTCCGGAACCCAGAGACTGCATCAGAGCCACTGTCTGA
GCCAGAGTCACAGCGGAAGGAGTTTGCAGAGAAGCTGGAGTCCCTGCTGCACCGTGCCTACCACCTGCAGGAGGAGTTCGGCTCCACCTT
CCCCGCAGACAGCATGCTGCTAGACCTCGAGAGGACCCTCATGCTGCCCCTGACCGAGGGCTCGCTGCGGCTGCGGGCGGACGATGAGGA
CAGCCTGACTTCAGAGGATTCCTTCTTCTCCGCCACCGAGCTCTTTGAGTCCCTGCAGACTGGAGATTACCCGATCCCACTCTCCAGACC
CGCCGCTGCCTATGAGGAGGCCCTGCAGCTGGTGAAGGAGGGGAGAGTGCCTTGCCGGACCCTCAGGACGGAGCTGCTGGGCTGCTACAG
TGACCAGGACTTTCTGGCCAAGCTGCACTGTGTGCGGCAGGCCTTCGAGGGGCTTCTGGAAGACAAGAGTAACCAGCTTTTCTTCGGGAA
AGTGGGCCGACAGATGGTGACAGGCCTGATGACCAAGGCTGAGAAGTTTGATGAAGGCCGGAACAACTTTGAAGGGGAGGTCACCAAGGA
GAACCTGCTGGACTTTATCAAACACAACCAGCTGCCCCTTGTCATCGAGTTCACCGAGCAGACAGCCCCGAAGATTTTTGGAGGTGAAAT
CAAGACTCACATCCTGCTGTTCTTGCCCAAGAGTGTGTCTGACTATGACGGCAAACTGAGCAACTTCAAAACAGCAGCCGAGAGCTTCAA
GGGCAAGATCCTGTTCATCTTCATCGACAGCGACCACACCGACAACCAGCGCATCCTCGAGTTCTTTGGCCTGAAGAAGGAAGAGTGCCC
GGCCGTGCGCCTCATCACCCTGGAGGAGGAGATGACCAAGTACAAGCCCGAATCGGAGGAGCTGACGGCAGAGAGGATCACAGAGTTCTG
CCACCGCTTCCTGGAGGGCAAAATCAAGCCCCACCTGATGAGCCAGGAGCTGCCGGAGGACTGGGACAAGCAGCCTGTCAAGGTGCTTGT
TGGGAAGAACTTTGAAGACGTGGCTTTTGATGAGAAAAAAAACGTCTTTGTGGAGTTCTATGCCCCATGGTGTGGTCACTGCAAACAGTT
GGCTCCCATTTGGGATAAACTGGGAGAGACGTACAAGGACCATGAGAACATCGTCATCGCCAAGATGGACTCGACTGCCAACGAGGTGGA
GGCCGTCAAAGTGCACAGCTTCCCCACACTCAAGTTCTTTCCTGCCAGTGCCGACAGGACGGTCATTGATTACAACGGGGAACGCACGCT
GGATGGTTTTAAGAAATTCCTGGAGAGCGGTGGCCAGGATGGGGCAGGGGATGATGACGATCTCGAGGACCTGGAAGAAGCAGAGGAGCC
AGACATGGAGGAAGACGATGATCAGAAAGCTGTGAAAGATGAACTGTAATACGCAAAGCCAGACCCGGGCGCTGCCGAGACCCCTCGGGG
GCTGCACACCCAGCAGCAGCGCACGCCTCCGAAGCCTGCGGCCTCGCTTGAAGGAGGGCGTCGCCGGAAACCCAGGGAACCTCTCTGAAG
TGACACCTCACCCCTACACACCGTCCGTTCACCCCCGTCTCTTCCTTCTGCTTTTCGGTTTTTGGAAAGGGATCCATCTCCAGGCAGCCC
ACCCTGGTGGGGCTTGTTTCCTGAAACCATGATGTACTTTTTCATACATGAGTCTGTCCAGAGTGCTTGCTACCGTGTTCGGAGTCTCGC
TGCCTCCCTCCCGCGGGAGGTTTCTCCTCTTTTTGAAAATTCCGTCTGTGGGATTTTTAGACATTTTTCGACATCAGGGTATTTGTTCCA
CCTTGGCCAGGCCTCCTCGGAGAAGCTTGTCCCCCGTGTGGGAGGGACGGAGCCGGACTGGACATGGTCACTCAGTACCGCCTGCAGTGT
CGCCATGACTGATCATGGCTCTTGCATTTTTGGGTAAATGGAGACTTCCGGATCCTGTCAGGGTGTCCCCCATGCCTGGAAGAGGAGCTG
GTGGCTGCCAGCCCTGGGGCCCGGCACAGGCCTGGGCCTTCCCCTTCCCTCAAGCCAGGGCTCCTCCTCCTGTCGTGGGCTCATTGTGAC
CACTGGCCTCTCTACAGCACGGCCTGTGGCCTGTTCAAGGCAGAACCACGACCCTTGACTCCCGGGTGGGGAGGTGGCCAAGGATGCTGG
AGCTGAATCAGACGCTGACAGTTCTTCAGGCATTTCTATTTCACAATCGAATTGAACACATTGGCCAAATAAAGTTGAAATTTTACCACC
TG

>29194_29194_1_FAM73B-P4HB_FAM73B_chr9_131825910_ENST00000358369_P4HB_chr17_79805223_ENST00000331483_length(amino acids)=754AA_BP=454
MEGAGVRAVSGARGYLALWRGPLVCVSLSFWGVDGAWDPAGNQLKTFSLEALGPEDFAWGIGPAMAFRRAEGTSMIQALAMTVAEIPVFL
YTTFGQSAFSQLRLTPGLRKVLFATALGTVALALAAHQLKRRRRRKKQVGPEMGGEQLGTVPLPILLARKVPSVKKGYSSRRVQSPSSKS
NDTLSGISSIEPSKHSGSSHSVASMMAVNSSSPTAACSGLWDARGMEESLTTSDGNAESLYMQGMELFEEALQKWEQALSVGQRGDSGST
PMPRDGLRNPETASEPLSEPESQRKEFAEKLESLLHRAYHLQEEFGSTFPADSMLLDLERTLMLPLTEGSLRLRADDEDSLTSEDSFFSA
TELFESLQTGDYPIPLSRPAAAYEEALQLVKEGRVPCRTLRTELLGCYSDQDFLAKLHCVRQAFEGLLEDKSNQLFFGKVGRQMVTGLMT
KAEKFDEGRNNFEGEVTKENLLDFIKHNQLPLVIEFTEQTAPKIFGGEIKTHILLFLPKSVSDYDGKLSNFKTAAESFKGKILFIFIDSD
HTDNQRILEFFGLKKEECPAVRLITLEEEMTKYKPESEELTAERITEFCHRFLEGKIKPHLMSQELPEDWDKQPVKVLVGKNFEDVAFDE
KKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHENIVIAKMDSTANEVEAVKVHSFPTLKFFPASADRTVIDYNGERTLDGFKKFLESGG
QDGAGDDDDLEDLEEAEEPDMEEDDDQKAVKDEL

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Fusion Gene PPI Analysis for MIGA2-P4HB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for MIGA2-P4HB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for MIGA2-P4HB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC4317154COLE-CARPENTER SYNDROME 12GENOMICS_ENGLAND;UNIPROT
TgeneC0001787Osteoporosis, Age-Related1CTD_human
TgeneC0019193Hepatitis, Toxic1CTD_human
TgeneC0029434Osteogenesis Imperfecta1GENOMICS_ENGLAND
TgeneC0029456Osteoporosis1CTD_human
TgeneC0029459Osteoporosis, Senile1CTD_human
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0151744Myocardial Ischemia1CTD_human
TgeneC0376358Malignant neoplasm of prostate1CTD_human
TgeneC0751406Post-Traumatic Osteoporosis1CTD_human
TgeneC0860207Drug-Induced Liver Disease1CTD_human
TgeneC1262760Hepatitis, Drug-Induced1CTD_human
TgeneC1846707SPINOCEREBELLAR ATAXIA 171CTD_human
TgeneC1862178Cole Carpenter syndrome1CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneC4279912Chemically-Induced Liver Toxicity1CTD_human