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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATAD1-FAM35A (FusionGDB2 ID:HG84896TG54537)

Fusion Gene Summary for ATAD1-FAM35A

check button Fusion gene summary
Fusion gene informationFusion gene name: ATAD1-FAM35A
Fusion gene ID: hg84896tg54537
HgeneTgene
Gene symbol

ATAD1

FAM35A

Gene ID

84896

54537

Gene nameATPase family AAA domain containing 1shieldin complex subunit 2
SynonymsAFDC1|FNP001|HKPX4|Msp1|THORASEFAM35A|FAM35A1|RINN2|bA163M19.1
Cytomap('ATAD1')('FAM35A')

10q23.31

10q23.2

Type of geneprotein-codingprotein-coding
DescriptionATPase family AAA domain-containing protein 1shieldin complex subunit 2RINN1-REV7-interacting novel NHEJ regulator 2family with sequence similarity 35 member Aprotein FAM35Ashield complex subunit 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000308448, ENST00000541004, 
ENST00000328142, ENST00000400215, 
ENST00000495903, 
Fusion gene scores* DoF score11 X 8 X 7=6163 X 3 X 3=27
# samples 123
** MAII scorelog2(12/616*10)=-2.35989594508638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ATAD1 [Title/Abstract] AND FAM35A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATAD1(89544227)-FAM35A(88930235), # samples:1
Anticipated loss of major functional domain due to fusion event.ATAD1-FAM35A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATAD1-FAM35A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATAD1-FAM35A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATAD1-FAM35A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATAD1-FAM35A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFAM35A

GO:0045830

positive regulation of isotype switching

29656893

TgeneFAM35A

GO:2000042

negative regulation of double-strand break repair via homologous recombination

29656893

TgeneFAM35A

GO:2001034

positive regulation of double-strand break repair via nonhomologous end joining

29656893|29789392


check buttonFusion gene breakpoints across ATAD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across FAM35A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-19-A6J5-01AATAD1chr10

89544227

-FAM35Achr10

88930235

+


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Fusion Gene ORF analysis for ATAD1-FAM35A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000308448ENST00000298784ATAD1chr10

89544227

-FAM35Achr10

88930235

+
Frame-shiftENST00000308448ENST00000298786ATAD1chr10

89544227

-FAM35Achr10

88930235

+
Frame-shiftENST00000541004ENST00000298784ATAD1chr10

89544227

-FAM35Achr10

88930235

+
Frame-shiftENST00000541004ENST00000298786ATAD1chr10

89544227

-FAM35Achr10

88930235

+
In-frameENST00000328142ENST00000298784ATAD1chr10

89544227

-FAM35Achr10

88930235

+
In-frameENST00000328142ENST00000298786ATAD1chr10

89544227

-FAM35Achr10

88930235

+
In-frameENST00000400215ENST00000298784ATAD1chr10

89544227

-FAM35Achr10

88930235

+
In-frameENST00000400215ENST00000298786ATAD1chr10

89544227

-FAM35Achr10

88930235

+
intron-3CDSENST00000495903ENST00000298784ATAD1chr10

89544227

-FAM35Achr10

88930235

+
intron-3CDSENST00000495903ENST00000298786ATAD1chr10

89544227

-FAM35Achr10

88930235

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000328142ATAD1chr1089544227-ENST00000298784FAM35Achr1088930235+25218662531740495
ENST00000328142ATAD1chr1089544227-ENST00000298786FAM35Achr1088930235+27338662531947564
ENST00000400215ATAD1chr1089544227-ENST00000298784FAM35Achr1088930235+2078423141297427
ENST00000400215ATAD1chr1089544227-ENST00000298786FAM35Achr1088930235+2290423141504496

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000328142ENST00000298784ATAD1chr1089544227-FAM35Achr1088930235+0.0003079860.9996921
ENST00000328142ENST00000298786ATAD1chr1089544227-FAM35Achr1088930235+0.0003091880.9996909
ENST00000400215ENST00000298784ATAD1chr1089544227-FAM35Achr1088930235+0.0007681090.99923193
ENST00000400215ENST00000298786ATAD1chr1089544227-FAM35Achr1088930235+0.0006082020.9993918

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Fusion Genomic Features for ATAD1-FAM35A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ATAD1chr1089544226-FAM35Achr1088930234+6.76E-070.9999993
ATAD1chr1089544226-FAM35Achr1088930234+6.76E-070.9999993

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ATAD1-FAM35A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:89544227/chr10:88930235)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATAD1chr10:89544227chr10:88930235ENST00000308448-510133_140194362.0Nucleotide bindingATP
HgeneATAD1chr10:89544227chr10:88930235ENST00000328142-49133_140194362.0Nucleotide bindingATP
HgeneATAD1chr10:89544227chr10:88930235ENST00000541004-59133_140194288.0Nucleotide bindingATP
HgeneATAD1chr10:89544227chr10:88930235ENST00000308448-5101_15194362.0Topological domainMitochondrial intermembrane
HgeneATAD1chr10:89544227chr10:88930235ENST00000328142-491_15194362.0Topological domainMitochondrial intermembrane
HgeneATAD1chr10:89544227chr10:88930235ENST00000541004-591_15194288.0Topological domainMitochondrial intermembrane
HgeneATAD1chr10:89544227chr10:88930235ENST00000308448-51016_32194362.0TransmembraneHelical
HgeneATAD1chr10:89544227chr10:88930235ENST00000328142-4916_32194362.0TransmembraneHelical
HgeneATAD1chr10:89544227chr10:88930235ENST00000541004-5916_32194288.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATAD1chr10:89544227chr10:88930235ENST00000308448-51033_361194362.0Topological domainCytoplasmic
HgeneATAD1chr10:89544227chr10:88930235ENST00000328142-4933_361194362.0Topological domainCytoplasmic
HgeneATAD1chr10:89544227chr10:88930235ENST00000541004-5933_361194288.0Topological domainCytoplasmic


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Fusion Gene Sequence for ATAD1-FAM35A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7327_7327_1_ATAD1-FAM35A_ATAD1_chr10_89544227_ENST00000328142_FAM35A_chr10_88930235_ENST00000298784_length(transcript)=2521nt_BP=866nt
GTATTTTTCAAATAAAATGATTAATTCTACTACCAAATAAATCTTAATTTCTAGTCTACTTCTAGTTTGCAAGAGGAGCTTTAAATGTAT
TTGTTTACTTAACATTTAAAAATCCATTTCTCCTTAAAATGAAACACTTTTTTTAAGGTAGGTAATATTTTAATTTGACTAGAAGTTAGT
TTTTCTTTCTTAGTTTAAGCTACTTTGTTAGTCTTACAATTTTAATAAGTATAGTTATTACCTAGTGACATTTCTGTTTGTTTTTTTAAG
GTTAACATTCAAGATGGTACATGCTGAAGCCTTTTCTCGTCCTTTGAGTCGGAATGAAGTTGTTGGTTTAATTTTCCGTTTGACAATATT
TGGTGCAGTGACATACTTTACTATCAAATGGATGGTAGATGCAATTGATCCAACCAGAAAGCAAAAAGTAGAAGCTCAGAAACAGGCAGA
AAAACTAATGAAGCAAATTGGAGTGAAAAATGTGAAGCTCTCAGAATATGAAATGAGTATTGCTGCTCATCTTGTAGACCCTCTTAATAT
GCATGTTACTTGGAGTGATATAGCAGGTTTAGATGATGTCATTACGGATCTGAAAGACACAGTCATCTTACCTATCAAAAAGAAACATTT
GTTTGAGAATTCCAGGCTTCTGCAGCCTCCAAAAGGTGTTCTTCTCTATGGGCCTCCAGGCTGTGGTAAAACGTTGATTGCCAAGGCCAC
AGCCAAAGAAGCAGGCTGTCGATTTATTAACCTTCAGCCTTCGACACTGACCGATAAGTGGTATGGAGAATCTCAGAAATTGGCTGCTGC
TGTCTTCTCCCTTGCCATAAAGCTACAACCATCCATCATCTTTATAGATGAAATAGATTCCAGTGTAGTTAGTGAAGTTGTACTTCAAGA
CTTACTGGCATATGTGTCCTCAAAACATTCCTACCTCAGAGATCTTCCTCCGAGGCAGCCTCAGAGGGTGAACAGTATAGACTTTGTAGA
ATTGGAGCACCTTCAACCTGATGTATTAGTCCACGCAGTACTAAGAGTTGTTGATTTCACTATACTGACAGAGGCAGTATACAGTTATAG
AGGACAGAAGCAGAAAAAAGTTATGTTAACAGTGGAACAGGCCCAAGATCAACATTATGCGCTTGTATTATGGGGTCCTGGAGCAGCCTG
GTACCCTCAACTTCAAAGGAAAAAAGGAGTGGTTCTGATTAAAGCCCAGATTTCAGAGCTGGCATTTCCTATTACAGCATCTCAGAAGAT
AGCGCTAAATGCTCACAGTTCTCTGAAGAGTATTTTTTCTTCTCTTCCCAACATCGTATATACTGGTTGTGCAAAATGTGGATTGGAACT
AGAAACAGATGAGAACAGGATCTACAAACAATGTTTTAGCTGCTTGCCATTTACTATGAAGAAAATATATTATAGGCCAGCGTTAATGAC
TGCCATTGATGGAAGACATGATGTTTGTATCCGTGTAGAATCAAAGCTGATAGAGAAGATTCTTCTCAACATTTCTGCAGACTGCCTCAA
CAGAGTGATAGTTCCTTCCTCAGAGATCACCTATGGGATGGTCGTGGCAGACCTGTTCCACTCCTTGTTGGCAGTCAGCGCAGAACCTTG
TGTATTAAAGATTCAGAGCCTTTTTGTGTTAGATGAAAACAGCTATCCATTACAACAAGATTTCTCCCTCCTGGATTTTTATCCTGACAT
TGTAAAGCATGGAGCCAATGCCCGTCTCTGAGGCCAGAGGAAGAAATTGCAGGCATTTCAAGGAAGAAGTACTGAAATGATTTGTCTTTT
GAAATAAATGAATGACAGGGCTTTTGCTTTGGATTTTTTATGAAATATATTTTACAAAGAGAATTGCACTAGATATATAAATTAAAACTT
TTTTCTAAGAAAATCCTGTGAGGTTTAAAAAGATTGTTTTTGTCTTTTGGTTTCTTACTTTCTCCTGGAGAAATGATCTACCAGTCAAGG
CAATATGTAGCAGATCCCTGGGAATTAAAGGTTTGCCCATTTGTTCACTGTATTTAGTCCCTGCTACATTCCAGGCATTGTACTAAGTAT
GGGGAACCACAGAGAAGACATTCCCTCAGAAACTGCTGCAGTGCTTTCGCTTATCCCTACCTAAAAAACCGTCAATGTGAAATCATTTCC
TTGATTATAACTATAATGATAATGGATTAGTTTATATAAACCTATGTTTAGACAAGTTCAAGACAAGCGTGTCTTTCTATAAAAAGTATT
GAAAATGAAGGAAATGAGATCATGTTTCAATTTATTAAAGCAGGGAAGAGCGTTCTGTGCTTAGTTCGTGTCTAGGATTTGAGTGCCTTA
CTGAATGCATTTACCAGCAAACATGTAGCAATCTGTTCTCTCATTGTGATTGTGGAAGAAGCTCATGTAAAATGATAGTCATTAATGAGG
AAGTATGGCGTGGTACTTATTCTGTAAGTTCAGAGTATGCTGAGTGTTAATAGATTATCATATTGCCTGAAAATAAATTCATGATGACAT

>7327_7327_1_ATAD1-FAM35A_ATAD1_chr10_89544227_ENST00000328142_FAM35A_chr10_88930235_ENST00000298784_length(amino acids)=495AA_BP=204
MFVFLRLTFKMVHAEAFSRPLSRNEVVGLIFRLTIFGAVTYFTIKWMVDAIDPTRKQKVEAQKQAEKLMKQIGVKNVKLSEYEMSIAAHL
VDPLNMHVTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGES
QKLAAAVFSLAIKLQPSIIFIDEIDSSVVSEVVLQDLLAYVSSKHSYLRDLPPRQPQRVNSIDFVELEHLQPDVLVHAVLRVVDFTILTE
AVYSYRGQKQKKVMLTVEQAQDQHYALVLWGPGAAWYPQLQRKKGVVLIKAQISELAFPITASQKIALNAHSSLKSIFSSLPNIVYTGCA
KCGLELETDENRIYKQCFSCLPFTMKKIYYRPALMTAIDGRHDVCIRVESKLIEKILLNISADCLNRVIVPSSEITYGMVVADLFHSLLA

--------------------------------------------------------------
>7327_7327_2_ATAD1-FAM35A_ATAD1_chr10_89544227_ENST00000328142_FAM35A_chr10_88930235_ENST00000298786_length(transcript)=2733nt_BP=866nt
GTATTTTTCAAATAAAATGATTAATTCTACTACCAAATAAATCTTAATTTCTAGTCTACTTCTAGTTTGCAAGAGGAGCTTTAAATGTAT
TTGTTTACTTAACATTTAAAAATCCATTTCTCCTTAAAATGAAACACTTTTTTTAAGGTAGGTAATATTTTAATTTGACTAGAAGTTAGT
TTTTCTTTCTTAGTTTAAGCTACTTTGTTAGTCTTACAATTTTAATAAGTATAGTTATTACCTAGTGACATTTCTGTTTGTTTTTTTAAG
GTTAACATTCAAGATGGTACATGCTGAAGCCTTTTCTCGTCCTTTGAGTCGGAATGAAGTTGTTGGTTTAATTTTCCGTTTGACAATATT
TGGTGCAGTGACATACTTTACTATCAAATGGATGGTAGATGCAATTGATCCAACCAGAAAGCAAAAAGTAGAAGCTCAGAAACAGGCAGA
AAAACTAATGAAGCAAATTGGAGTGAAAAATGTGAAGCTCTCAGAATATGAAATGAGTATTGCTGCTCATCTTGTAGACCCTCTTAATAT
GCATGTTACTTGGAGTGATATAGCAGGTTTAGATGATGTCATTACGGATCTGAAAGACACAGTCATCTTACCTATCAAAAAGAAACATTT
GTTTGAGAATTCCAGGCTTCTGCAGCCTCCAAAAGGTGTTCTTCTCTATGGGCCTCCAGGCTGTGGTAAAACGTTGATTGCCAAGGCCAC
AGCCAAAGAAGCAGGCTGTCGATTTATTAACCTTCAGCCTTCGACACTGACCGATAAGTGGTATGGAGAATCTCAGAAATTGGCTGCTGC
TGTCTTCTCCCTTGCCATAAAGCTACAACCATCCATCATCTTTATAGATGAAATAGATTCCAGTGTAGTTAGTGAAGTTGTACTTCAAGA
CTTACTGGCATATGTGTCCTCAAAACATTCCTACCTCAGAGATCTTCCTCCGAGGCAGCCTCAGAGGGTGAACAGTATAGACTTTGTAGA
ATTGGAGCACCTTCAACCTGATGTATTAGTCCACGCAGTACTAAGAGTTGTTGATTTCACTATACTGACAGAGGCAGTATACAGTTATAG
AGGACAGAAGCAGAAAAAAGTTATGTTAACAGTGGAACAGGCCCAAGATCAACATTATGCGCTTGTATTATGGGGTCCTGGAGCAGCCTG
GTACCCTCAACTTCAAAGGAAAAAAGGTTATATTTGGGAATTTAAATATCTTTTTGTTCAGTGCAATTACACACTAGAAAACCTAGAATT
GCATACAACGCCTTGGTCATCCTGTGAGTGCTTGTTTGATGATGATATAAGGGCAATTACATTTAAAGCAAAATTTCAAAAAAGTGCACC
CTCCTTTGTGAAGATATCAGACTTAGCAACCCACCTAGAGGATAAGTGTTCAGGAGTGGTTCTGATTAAAGCCCAGATTTCAGAGCTGGC
ATTTCCTATTACAGCATCTCAGAAGATAGCGCTAAATGCTCACAGTTCTCTGAAGAGTATTTTTTCTTCTCTTCCCAACATCGTATATAC
TGGTTGTGCAAAATGTGGATTGGAACTAGAAACAGATGAGAACAGGATCTACAAACAATGTTTTAGCTGCTTGCCATTTACTATGAAGAA
AATATATTATAGGCCAGCGTTAATGACTGCCATTGATGGAAGACATGATGTTTGTATCCGTGTAGAATCAAAGCTGATAGAGAAGATTCT
TCTCAACATTTCTGCAGACTGCCTCAACAGAGTGATAGTTCCTTCCTCAGAGATCACCTATGGGATGGTCGTGGCAGACCTGTTCCACTC
CTTGTTGGCAGTCAGCGCAGAACCTTGTGTATTAAAGATTCAGAGCCTTTTTGTGTTAGATGAAAACAGCTATCCATTACAACAAGATTT
CTCCCTCCTGGATTTTTATCCTGACATTGTAAAGCATGGAGCCAATGCCCGTCTCTGAGGCCAGAGGAAGAAATTGCAGGCATTTCAAGG
AAGAAGTACTGAAATGATTTGTCTTTTGAAATAAATGAATGACAGGGCTTTTGCTTTGGATTTTTTATGAAATATATTTTACAAAGAGAA
TTGCACTAGATATATAAATTAAAACTTTTTTCTAAGAAAATCCTGTGAGGTTTAAAAAGATTGTTTTTGTCTTTTGGTTTCTTACTTTCT
CCTGGAGAAATGATCTACCAGTCAAGGCAATATGTAGCAGATCCCTGGGAATTAAAGGTTTGCCCATTTGTTCACTGTATTTAGTCCCTG
CTACATTCCAGGCATTGTACTAAGTATGGGGAACCACAGAGAAGACATTCCCTCAGAAACTGCTGCAGTGCTTTCGCTTATCCCTACCTA
AAAAACCGTCAATGTGAAATCATTTCCTTGATTATAACTATAATGATAATGGATTAGTTTATATAAACCTATGTTTAGACAAGTTCAAGA
CAAGCGTGTCTTTCTATAAAAAGTATTGAAAATGAAGGAAATGAGATCATGTTTCAATTTATTAAAGCAGGGAAGAGCGTTCTGTGCTTA
GTTCGTGTCTAGGATTTGAGTGCCTTACTGAATGCATTTACCAGCAAACATGTAGCAATCTGTTCTCTCATTGTGATTGTGGAAGAAGCT
CATGTAAAATGATAGTCATTAATGAGGAAGTATGGCGTGGTACTTATTCTGTAAGTTCAGAGTATGCTGAGTGTTAATAGATTATCATAT

>7327_7327_2_ATAD1-FAM35A_ATAD1_chr10_89544227_ENST00000328142_FAM35A_chr10_88930235_ENST00000298786_length(amino acids)=564AA_BP=204
MFVFLRLTFKMVHAEAFSRPLSRNEVVGLIFRLTIFGAVTYFTIKWMVDAIDPTRKQKVEAQKQAEKLMKQIGVKNVKLSEYEMSIAAHL
VDPLNMHVTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGES
QKLAAAVFSLAIKLQPSIIFIDEIDSSVVSEVVLQDLLAYVSSKHSYLRDLPPRQPQRVNSIDFVELEHLQPDVLVHAVLRVVDFTILTE
AVYSYRGQKQKKVMLTVEQAQDQHYALVLWGPGAAWYPQLQRKKGYIWEFKYLFVQCNYTLENLELHTTPWSSCECLFDDDIRAITFKAK
FQKSAPSFVKISDLATHLEDKCSGVVLIKAQISELAFPITASQKIALNAHSSLKSIFSSLPNIVYTGCAKCGLELETDENRIYKQCFSCL
PFTMKKIYYRPALMTAIDGRHDVCIRVESKLIEKILLNISADCLNRVIVPSSEITYGMVVADLFHSLLAVSAEPCVLKIQSLFVLDENSY

--------------------------------------------------------------
>7327_7327_3_ATAD1-FAM35A_ATAD1_chr10_89544227_ENST00000400215_FAM35A_chr10_88930235_ENST00000298784_length(transcript)=2078nt_BP=423nt
AGGCAGAAAAACTAATGAAGCAAATTGGAGTGAAAAATGTGAAGCTCTCAGAATATGAAATGAGTATTGCTGCTCATCTTGTAGACCCTC
TTAATATGCATGTTACTTGGAGTGATATAGCAGGTTTAGATGATGTCATTACGGATCTGAAAGACACAGTCATCTTACCTATCAAAAAGA
AACATTTGTTTGAGAATTCCAGGCTTCTGCAGCCTCCAAAAGGTGTTCTTCTCTATGGGCCTCCAGGCTGTGGTAAAACGTTGATTGCCA
AGGCCACAGCCAAAGAAGCAGGCTGTCGATTTATTAACCTTCAGCCTTCGACACTGACCGATAAGTGGTATGGAGAATCTCAGAAATTGG
CTGCTGCTGTCTTCTCCCTTGCCATAAAGCTACAACCATCCATCATCTTTATAGATGAAATAGATTCCAGTGTAGTTAGTGAAGTTGTAC
TTCAAGACTTACTGGCATATGTGTCCTCAAAACATTCCTACCTCAGAGATCTTCCTCCGAGGCAGCCTCAGAGGGTGAACAGTATAGACT
TTGTAGAATTGGAGCACCTTCAACCTGATGTATTAGTCCACGCAGTACTAAGAGTTGTTGATTTCACTATACTGACAGAGGCAGTATACA
GTTATAGAGGACAGAAGCAGAAAAAAGTTATGTTAACAGTGGAACAGGCCCAAGATCAACATTATGCGCTTGTATTATGGGGTCCTGGAG
CAGCCTGGTACCCTCAACTTCAAAGGAAAAAAGGAGTGGTTCTGATTAAAGCCCAGATTTCAGAGCTGGCATTTCCTATTACAGCATCTC
AGAAGATAGCGCTAAATGCTCACAGTTCTCTGAAGAGTATTTTTTCTTCTCTTCCCAACATCGTATATACTGGTTGTGCAAAATGTGGAT
TGGAACTAGAAACAGATGAGAACAGGATCTACAAACAATGTTTTAGCTGCTTGCCATTTACTATGAAGAAAATATATTATAGGCCAGCGT
TAATGACTGCCATTGATGGAAGACATGATGTTTGTATCCGTGTAGAATCAAAGCTGATAGAGAAGATTCTTCTCAACATTTCTGCAGACT
GCCTCAACAGAGTGATAGTTCCTTCCTCAGAGATCACCTATGGGATGGTCGTGGCAGACCTGTTCCACTCCTTGTTGGCAGTCAGCGCAG
AACCTTGTGTATTAAAGATTCAGAGCCTTTTTGTGTTAGATGAAAACAGCTATCCATTACAACAAGATTTCTCCCTCCTGGATTTTTATC
CTGACATTGTAAAGCATGGAGCCAATGCCCGTCTCTGAGGCCAGAGGAAGAAATTGCAGGCATTTCAAGGAAGAAGTACTGAAATGATTT
GTCTTTTGAAATAAATGAATGACAGGGCTTTTGCTTTGGATTTTTTATGAAATATATTTTACAAAGAGAATTGCACTAGATATATAAATT
AAAACTTTTTTCTAAGAAAATCCTGTGAGGTTTAAAAAGATTGTTTTTGTCTTTTGGTTTCTTACTTTCTCCTGGAGAAATGATCTACCA
GTCAAGGCAATATGTAGCAGATCCCTGGGAATTAAAGGTTTGCCCATTTGTTCACTGTATTTAGTCCCTGCTACATTCCAGGCATTGTAC
TAAGTATGGGGAACCACAGAGAAGACATTCCCTCAGAAACTGCTGCAGTGCTTTCGCTTATCCCTACCTAAAAAACCGTCAATGTGAAAT
CATTTCCTTGATTATAACTATAATGATAATGGATTAGTTTATATAAACCTATGTTTAGACAAGTTCAAGACAAGCGTGTCTTTCTATAAA
AAGTATTGAAAATGAAGGAAATGAGATCATGTTTCAATTTATTAAAGCAGGGAAGAGCGTTCTGTGCTTAGTTCGTGTCTAGGATTTGAG
TGCCTTACTGAATGCATTTACCAGCAAACATGTAGCAATCTGTTCTCTCATTGTGATTGTGGAAGAAGCTCATGTAAAATGATAGTCATT
AATGAGGAAGTATGGCGTGGTACTTATTCTGTAAGTTCAGAGTATGCTGAGTGTTAATAGATTATCATATTGCCTGAAAATAAATTCATG

>7327_7327_3_ATAD1-FAM35A_ATAD1_chr10_89544227_ENST00000400215_FAM35A_chr10_88930235_ENST00000298784_length(amino acids)=427AA_BP=136
MKQIGVKNVKLSEYEMSIAAHLVDPLNMHVTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPPKGVLLYGPPGCGKTLIAKATAK
EAGCRFINLQPSTLTDKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSSVVSEVVLQDLLAYVSSKHSYLRDLPPRQPQRVNSIDFVELE
HLQPDVLVHAVLRVVDFTILTEAVYSYRGQKQKKVMLTVEQAQDQHYALVLWGPGAAWYPQLQRKKGVVLIKAQISELAFPITASQKIAL
NAHSSLKSIFSSLPNIVYTGCAKCGLELETDENRIYKQCFSCLPFTMKKIYYRPALMTAIDGRHDVCIRVESKLIEKILLNISADCLNRV

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>7327_7327_4_ATAD1-FAM35A_ATAD1_chr10_89544227_ENST00000400215_FAM35A_chr10_88930235_ENST00000298786_length(transcript)=2290nt_BP=423nt
AGGCAGAAAAACTAATGAAGCAAATTGGAGTGAAAAATGTGAAGCTCTCAGAATATGAAATGAGTATTGCTGCTCATCTTGTAGACCCTC
TTAATATGCATGTTACTTGGAGTGATATAGCAGGTTTAGATGATGTCATTACGGATCTGAAAGACACAGTCATCTTACCTATCAAAAAGA
AACATTTGTTTGAGAATTCCAGGCTTCTGCAGCCTCCAAAAGGTGTTCTTCTCTATGGGCCTCCAGGCTGTGGTAAAACGTTGATTGCCA
AGGCCACAGCCAAAGAAGCAGGCTGTCGATTTATTAACCTTCAGCCTTCGACACTGACCGATAAGTGGTATGGAGAATCTCAGAAATTGG
CTGCTGCTGTCTTCTCCCTTGCCATAAAGCTACAACCATCCATCATCTTTATAGATGAAATAGATTCCAGTGTAGTTAGTGAAGTTGTAC
TTCAAGACTTACTGGCATATGTGTCCTCAAAACATTCCTACCTCAGAGATCTTCCTCCGAGGCAGCCTCAGAGGGTGAACAGTATAGACT
TTGTAGAATTGGAGCACCTTCAACCTGATGTATTAGTCCACGCAGTACTAAGAGTTGTTGATTTCACTATACTGACAGAGGCAGTATACA
GTTATAGAGGACAGAAGCAGAAAAAAGTTATGTTAACAGTGGAACAGGCCCAAGATCAACATTATGCGCTTGTATTATGGGGTCCTGGAG
CAGCCTGGTACCCTCAACTTCAAAGGAAAAAAGGTTATATTTGGGAATTTAAATATCTTTTTGTTCAGTGCAATTACACACTAGAAAACC
TAGAATTGCATACAACGCCTTGGTCATCCTGTGAGTGCTTGTTTGATGATGATATAAGGGCAATTACATTTAAAGCAAAATTTCAAAAAA
GTGCACCCTCCTTTGTGAAGATATCAGACTTAGCAACCCACCTAGAGGATAAGTGTTCAGGAGTGGTTCTGATTAAAGCCCAGATTTCAG
AGCTGGCATTTCCTATTACAGCATCTCAGAAGATAGCGCTAAATGCTCACAGTTCTCTGAAGAGTATTTTTTCTTCTCTTCCCAACATCG
TATATACTGGTTGTGCAAAATGTGGATTGGAACTAGAAACAGATGAGAACAGGATCTACAAACAATGTTTTAGCTGCTTGCCATTTACTA
TGAAGAAAATATATTATAGGCCAGCGTTAATGACTGCCATTGATGGAAGACATGATGTTTGTATCCGTGTAGAATCAAAGCTGATAGAGA
AGATTCTTCTCAACATTTCTGCAGACTGCCTCAACAGAGTGATAGTTCCTTCCTCAGAGATCACCTATGGGATGGTCGTGGCAGACCTGT
TCCACTCCTTGTTGGCAGTCAGCGCAGAACCTTGTGTATTAAAGATTCAGAGCCTTTTTGTGTTAGATGAAAACAGCTATCCATTACAAC
AAGATTTCTCCCTCCTGGATTTTTATCCTGACATTGTAAAGCATGGAGCCAATGCCCGTCTCTGAGGCCAGAGGAAGAAATTGCAGGCAT
TTCAAGGAAGAAGTACTGAAATGATTTGTCTTTTGAAATAAATGAATGACAGGGCTTTTGCTTTGGATTTTTTATGAAATATATTTTACA
AAGAGAATTGCACTAGATATATAAATTAAAACTTTTTTCTAAGAAAATCCTGTGAGGTTTAAAAAGATTGTTTTTGTCTTTTGGTTTCTT
ACTTTCTCCTGGAGAAATGATCTACCAGTCAAGGCAATATGTAGCAGATCCCTGGGAATTAAAGGTTTGCCCATTTGTTCACTGTATTTA
GTCCCTGCTACATTCCAGGCATTGTACTAAGTATGGGGAACCACAGAGAAGACATTCCCTCAGAAACTGCTGCAGTGCTTTCGCTTATCC
CTACCTAAAAAACCGTCAATGTGAAATCATTTCCTTGATTATAACTATAATGATAATGGATTAGTTTATATAAACCTATGTTTAGACAAG
TTCAAGACAAGCGTGTCTTTCTATAAAAAGTATTGAAAATGAAGGAAATGAGATCATGTTTCAATTTATTAAAGCAGGGAAGAGCGTTCT
GTGCTTAGTTCGTGTCTAGGATTTGAGTGCCTTACTGAATGCATTTACCAGCAAACATGTAGCAATCTGTTCTCTCATTGTGATTGTGGA
AGAAGCTCATGTAAAATGATAGTCATTAATGAGGAAGTATGGCGTGGTACTTATTCTGTAAGTTCAGAGTATGCTGAGTGTTAATAGATT

>7327_7327_4_ATAD1-FAM35A_ATAD1_chr10_89544227_ENST00000400215_FAM35A_chr10_88930235_ENST00000298786_length(amino acids)=496AA_BP=136
MKQIGVKNVKLSEYEMSIAAHLVDPLNMHVTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPPKGVLLYGPPGCGKTLIAKATAK
EAGCRFINLQPSTLTDKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSSVVSEVVLQDLLAYVSSKHSYLRDLPPRQPQRVNSIDFVELE
HLQPDVLVHAVLRVVDFTILTEAVYSYRGQKQKKVMLTVEQAQDQHYALVLWGPGAAWYPQLQRKKGYIWEFKYLFVQCNYTLENLELHT
TPWSSCECLFDDDIRAITFKAKFQKSAPSFVKISDLATHLEDKCSGVVLIKAQISELAFPITASQKIALNAHSSLKSIFSSLPNIVYTGC
AKCGLELETDENRIYKQCFSCLPFTMKKIYYRPALMTAIDGRHDVCIRVESKLIEKILLNISADCLNRVIVPSSEITYGMVVADLFHSLL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ATAD1-FAM35A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATAD1-FAM35A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATAD1-FAM35A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATAD1C4693933HYPEREKPLEXIA 43GENOMICS_ENGLAND;UNIPROT
HgeneATAD1C1835614Hereditary Hyperexplexia1ORPHANET