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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATAD1-LIPF (FusionGDB2 ID:HG84896TG8513)

Fusion Gene Summary for ATAD1-LIPF

check button Fusion gene summary
Fusion gene informationFusion gene name: ATAD1-LIPF
Fusion gene ID: hg84896tg8513
HgeneTgene
Gene symbol

ATAD1

LIPF

Gene ID

84896

8513

Gene nameATPase family AAA domain containing 1lipase F, gastric type
SynonymsAFDC1|FNP001|HKPX4|Msp1|THORASEGL|HGL|HLAL
Cytomap('ATAD1')('LIPF')

10q23.31

10q23.31

Type of geneprotein-codingprotein-coding
DescriptionATPase family AAA domain-containing protein 1gastric triacylglycerol lipasegastric lipaselipase, gastric
Modification date2020031320200313
UniProtAcc.

P07098

Ensembl transtripts involved in fusion geneENST00000308448, ENST00000328142, 
ENST00000400215, ENST00000541004, 
ENST00000495903, 
Fusion gene scores* DoF score11 X 8 X 7=61617 X 18 X 7=2142
# samples 1218
** MAII scorelog2(12/616*10)=-2.35989594508638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(18/2142*10)=-3.57288966842058
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATAD1 [Title/Abstract] AND LIPF [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATAD1(89550067)-LIPF(90427044), # samples:3
Anticipated loss of major functional domain due to fusion event.ATAD1-LIPF seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATAD1-LIPF seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATAD1-LIPF seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ATAD1-LIPF seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ATAD1-LIPF seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ATAD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across LIPF (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-E1-A7YN-01AATAD1chr10

89550067

-LIPFchr10

90427044

+
ChimerDB4LGGTCGA-E1-A7YNATAD1chr10

89550066

-LIPFchr10

90427043

+
ChimerDB4LGGTCGA-E1-A7YNATAD1chr10

89550067

-LIPFchr10

90427044

+


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Fusion Gene ORF analysis for ATAD1-LIPF

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000308448ENST00000238983ATAD1chr10

89550067

-LIPFchr10

90427044

+
5CDS-5UTRENST00000308448ENST00000238983ATAD1chr10

89550066

-LIPFchr10

90427043

+
5CDS-5UTRENST00000308448ENST00000355843ATAD1chr10

89550067

-LIPFchr10

90427044

+
5CDS-5UTRENST00000308448ENST00000355843ATAD1chr10

89550066

-LIPFchr10

90427043

+
5CDS-5UTRENST00000308448ENST00000608620ATAD1chr10

89550067

-LIPFchr10

90427044

+
5CDS-5UTRENST00000308448ENST00000608620ATAD1chr10

89550066

-LIPFchr10

90427043

+
5CDS-5UTRENST00000328142ENST00000238983ATAD1chr10

89550067

-LIPFchr10

90427044

+
5CDS-5UTRENST00000328142ENST00000238983ATAD1chr10

89550066

-LIPFchr10

90427043

+
5CDS-5UTRENST00000328142ENST00000355843ATAD1chr10

89550067

-LIPFchr10

90427044

+
5CDS-5UTRENST00000328142ENST00000355843ATAD1chr10

89550066

-LIPFchr10

90427043

+
5CDS-5UTRENST00000328142ENST00000608620ATAD1chr10

89550067

-LIPFchr10

90427044

+
5CDS-5UTRENST00000328142ENST00000608620ATAD1chr10

89550066

-LIPFchr10

90427043

+
5CDS-5UTRENST00000400215ENST00000238983ATAD1chr10

89550067

-LIPFchr10

90427044

+
5CDS-5UTRENST00000400215ENST00000238983ATAD1chr10

89550066

-LIPFchr10

90427043

+
5CDS-5UTRENST00000400215ENST00000355843ATAD1chr10

89550067

-LIPFchr10

90427044

+
5CDS-5UTRENST00000400215ENST00000355843ATAD1chr10

89550066

-LIPFchr10

90427043

+
5CDS-5UTRENST00000400215ENST00000608620ATAD1chr10

89550067

-LIPFchr10

90427044

+
5CDS-5UTRENST00000400215ENST00000608620ATAD1chr10

89550066

-LIPFchr10

90427043

+
5CDS-5UTRENST00000541004ENST00000238983ATAD1chr10

89550067

-LIPFchr10

90427044

+
5CDS-5UTRENST00000541004ENST00000238983ATAD1chr10

89550066

-LIPFchr10

90427043

+
5CDS-5UTRENST00000541004ENST00000355843ATAD1chr10

89550067

-LIPFchr10

90427044

+
5CDS-5UTRENST00000541004ENST00000355843ATAD1chr10

89550066

-LIPFchr10

90427043

+
5CDS-5UTRENST00000541004ENST00000608620ATAD1chr10

89550067

-LIPFchr10

90427044

+
5CDS-5UTRENST00000541004ENST00000608620ATAD1chr10

89550066

-LIPFchr10

90427043

+
5UTR-3CDSENST00000495903ENST00000394375ATAD1chr10

89550067

-LIPFchr10

90427044

+
5UTR-3CDSENST00000495903ENST00000394375ATAD1chr10

89550066

-LIPFchr10

90427043

+
5UTR-5UTRENST00000495903ENST00000238983ATAD1chr10

89550067

-LIPFchr10

90427044

+
5UTR-5UTRENST00000495903ENST00000238983ATAD1chr10

89550066

-LIPFchr10

90427043

+
5UTR-5UTRENST00000495903ENST00000355843ATAD1chr10

89550067

-LIPFchr10

90427044

+
5UTR-5UTRENST00000495903ENST00000355843ATAD1chr10

89550066

-LIPFchr10

90427043

+
5UTR-5UTRENST00000495903ENST00000608620ATAD1chr10

89550067

-LIPFchr10

90427044

+
5UTR-5UTRENST00000495903ENST00000608620ATAD1chr10

89550066

-LIPFchr10

90427043

+
Frame-shiftENST00000308448ENST00000394375ATAD1chr10

89550067

-LIPFchr10

90427044

+
Frame-shiftENST00000308448ENST00000394375ATAD1chr10

89550066

-LIPFchr10

90427043

+
Frame-shiftENST00000541004ENST00000394375ATAD1chr10

89550067

-LIPFchr10

90427044

+
Frame-shiftENST00000541004ENST00000394375ATAD1chr10

89550066

-LIPFchr10

90427043

+
In-frameENST00000328142ENST00000394375ATAD1chr10

89550067

-LIPFchr10

90427044

+
In-frameENST00000328142ENST00000394375ATAD1chr10

89550066

-LIPFchr10

90427043

+
In-frameENST00000400215ENST00000394375ATAD1chr10

89550067

-LIPFchr10

90427044

+
In-frameENST00000400215ENST00000394375ATAD1chr10

89550066

-LIPFchr10

90427043

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000328142ATAD1chr1089550067-ENST00000394375LIPFchr1090427044+20036652531872539
ENST00000400215ATAD1chr1089550067-ENST00000394375LIPFchr1090427044+1560222141429471
ENST00000328142ATAD1chr1089550066-ENST00000394375LIPFchr1090427043+20036652531872539
ENST00000400215ATAD1chr1089550066-ENST00000394375LIPFchr1090427043+1560222141429471

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000328142ENST00000394375ATAD1chr1089550067-LIPFchr1090427044+0.0002107860.9997892
ENST00000400215ENST00000394375ATAD1chr1089550067-LIPFchr1090427044+0.0020473040.9979527
ENST00000328142ENST00000394375ATAD1chr1089550066-LIPFchr1090427043+0.0002107860.9997892
ENST00000400215ENST00000394375ATAD1chr1089550066-LIPFchr1090427043+0.0020473040.9979527

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Fusion Genomic Features for ATAD1-LIPF


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ATAD1chr1089550066-LIPFchr1090427043+1.43E-070.9999999
ATAD1chr1089550066-LIPFchr1090427043+1.43E-070.9999999
ATAD1chr1089550066-LIPFchr1090427043+1.43E-070.9999999
ATAD1chr1089550066-LIPFchr1090427043+1.43E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ATAD1-LIPF


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:89550067/chr10:90427044)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LIPF

P07098

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Catalyzes the hydrolysis of triacylglycerols to yield free fatty acids, diacylglycerol, monoacylglycerol, and glycerol (PubMed:2243091, PubMed:10358049). Shows a preferential hydrolysis at the sn-3 position of triacylglycerol (PubMed:2243091). {ECO:0000269|PubMed:10358049, ECO:0000269|PubMed:2243091}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATAD1chr10:89550066chr10:90427043ENST00000308448-4101_15127362.0Topological domainMitochondrial intermembrane
HgeneATAD1chr10:89550066chr10:90427043ENST00000328142-391_15127362.0Topological domainMitochondrial intermembrane
HgeneATAD1chr10:89550066chr10:90427043ENST00000541004-491_15127288.0Topological domainMitochondrial intermembrane
HgeneATAD1chr10:89550067chr10:90427044ENST00000308448-4101_15127362.0Topological domainMitochondrial intermembrane
HgeneATAD1chr10:89550067chr10:90427044ENST00000328142-391_15127362.0Topological domainMitochondrial intermembrane
HgeneATAD1chr10:89550067chr10:90427044ENST00000541004-491_15127288.0Topological domainMitochondrial intermembrane
HgeneATAD1chr10:89550066chr10:90427043ENST00000308448-41016_32127362.0TransmembraneHelical
HgeneATAD1chr10:89550066chr10:90427043ENST00000328142-3916_32127362.0TransmembraneHelical
HgeneATAD1chr10:89550066chr10:90427043ENST00000541004-4916_32127288.0TransmembraneHelical
HgeneATAD1chr10:89550067chr10:90427044ENST00000308448-41016_32127362.0TransmembraneHelical
HgeneATAD1chr10:89550067chr10:90427044ENST00000328142-3916_32127362.0TransmembraneHelical
HgeneATAD1chr10:89550067chr10:90427044ENST00000541004-4916_32127288.0TransmembraneHelical
TgeneLIPFchr10:89550066chr10:90427043ENST0000023898301078_3770399.0DomainAB hydrolase-1
TgeneLIPFchr10:89550066chr10:90427043ENST0000035584311178_3776376.0DomainAB hydrolase-1
TgeneLIPFchr10:89550066chr10:90427043ENST0000039437511178_3776409.0DomainAB hydrolase-1
TgeneLIPFchr10:89550067chr10:90427044ENST0000023898301078_3770399.0DomainAB hydrolase-1
TgeneLIPFchr10:89550067chr10:90427044ENST0000035584311178_3776376.0DomainAB hydrolase-1
TgeneLIPFchr10:89550067chr10:90427044ENST0000039437511178_3776409.0DomainAB hydrolase-1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATAD1chr10:89550066chr10:90427043ENST00000308448-410133_140127362.0Nucleotide bindingATP
HgeneATAD1chr10:89550066chr10:90427043ENST00000328142-39133_140127362.0Nucleotide bindingATP
HgeneATAD1chr10:89550066chr10:90427043ENST00000541004-49133_140127288.0Nucleotide bindingATP
HgeneATAD1chr10:89550067chr10:90427044ENST00000308448-410133_140127362.0Nucleotide bindingATP
HgeneATAD1chr10:89550067chr10:90427044ENST00000328142-39133_140127362.0Nucleotide bindingATP
HgeneATAD1chr10:89550067chr10:90427044ENST00000541004-49133_140127288.0Nucleotide bindingATP
HgeneATAD1chr10:89550066chr10:90427043ENST00000308448-41033_361127362.0Topological domainCytoplasmic
HgeneATAD1chr10:89550066chr10:90427043ENST00000328142-3933_361127362.0Topological domainCytoplasmic
HgeneATAD1chr10:89550066chr10:90427043ENST00000541004-4933_361127288.0Topological domainCytoplasmic
HgeneATAD1chr10:89550067chr10:90427044ENST00000308448-41033_361127362.0Topological domainCytoplasmic
HgeneATAD1chr10:89550067chr10:90427044ENST00000328142-3933_361127362.0Topological domainCytoplasmic
HgeneATAD1chr10:89550067chr10:90427044ENST00000541004-4933_361127288.0Topological domainCytoplasmic


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Fusion Gene Sequence for ATAD1-LIPF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7330_7330_1_ATAD1-LIPF_ATAD1_chr10_89550066_ENST00000328142_LIPF_chr10_90427043_ENST00000394375_length(transcript)=2003nt_BP=665nt
GTATTTTTCAAATAAAATGATTAATTCTACTACCAAATAAATCTTAATTTCTAGTCTACTTCTAGTTTGCAAGAGGAGCTTTAAATGTAT
TTGTTTACTTAACATTTAAAAATCCATTTCTCCTTAAAATGAAACACTTTTTTTAAGGTAGGTAATATTTTAATTTGACTAGAAGTTAGT
TTTTCTTTCTTAGTTTAAGCTACTTTGTTAGTCTTACAATTTTAATAAGTATAGTTATTACCTAGTGACATTTCTGTTTGTTTTTTTAAG
GTTAACATTCAAGATGGTACATGCTGAAGCCTTTTCTCGTCCTTTGAGTCGGAATGAAGTTGTTGGTTTAATTTTCCGTTTGACAATATT
TGGTGCAGTGACATACTTTACTATCAAATGGATGGTAGATGCAATTGATCCAACCAGAAAGCAAAAAGTAGAAGCTCAGAAACAGGCAGA
AAAACTAATGAAGCAAATTGGAGTGAAAAATGTGAAGCTCTCAGAATATGAAATGAGTATTGCTGCTCATCTTGTAGACCCTCTTAATAT
GCATGTTACTTGGAGTGATATAGCAGGTTTAGATGATGTCATTACGGATCTGAAAGACACAGTCATCTTACCTATCAAAAAGAAACATTT
GTTTGAGAATTCCAGGCTTCTGCAGCCTCCAAAAGGCAGGTCCAAAATGTGGCTGCTTTTAACAATGGCAAGTTTGATATCTGTACTGGG
GACTACACATGGTTTGTTTGGAAAATTACATCCTGGAAGCCCTGAAGTGACTATGAACATTAGTCAGATGATTACTTATTGGGGATACCC
AAATGAAGAATATGAAGTTGTGACTGAAGATGGTTATATTCTTGAAGTCAATAGAATTCCTTATGGGAAGAAAAATTCAGGGAATACAGG
CCAGAGACCTGTTGTGTTTTTGCAGCATGGTTTGCTTGCATCAGCCACAAACTGGATTTCCAACCTGCCGAACAACAGCCTTGCCTTCAT
TCTGGCAGATGCTGGTTATGATGTGTGGCTGGGCAACAGCAGAGGAAACACCTGGGCCAGAAGAAACTTGTACTATTCACCAGATTCAGT
TGAATTCTGGGCTTTCAGCTTTGATGAAATGGCTAAATATGACCTTCCAGCCACAATCGACTTCATTGTAAAGAAAACTGGACAGAAGCA
GCTACACTATGTTGGCCATTCCCAGGGCACCACCATTGGTTTTATTGCCTTTTCCACCAATCCCAGCCTGGCTAAAAGAATCAAAACCTT
CTATGCTCTAGCTCCTGTTGCCACTGTGAAGTATACAAAAAGCCTTATAAACAAACTTAGATTTGTTCCTCAATCCCTCTTCAAGTTTAT
ATTTGGTGACAAAATATTCTACCCACACAACTTCTTTGATCAATTTCTTGCTACTGAAGTGTGCTCCCGTGAGATGCTGAATCTCCTTTG
CAGCAATGCCTTATTTATAATTTGTGGATTTGACAGTAAGAACTTTAACACGAGTCGCTTGGATGTGTATCTATCACATAATCCAGCAGG
AACTTCTGTTCAAAACATGTTCCATTGGACCCAGGCTGTTAAGTCTGGGAAATTCCAAGCTTATGACTGGGGAAGCCCAGTTCAGAATAG
GATGCACTATGATCAGTCCCAACCTCCCTACTACAATGTGACAGCCATGAATGTACCAATTGCAGTGTGGAACGGTGGCAAGGACCTGTT
GGCTGACCCCCAAGATGTTGGCCTTTTGCTTCCAAAACTCCCCAATCTTATTTACCACAAGGAGATTCCTTTTTACAATCACTTGGACTT
TATCTGGGCAATGGATGCCCCTCAAGAAGTTTACAATGACATTGTTTCTATGATATCAGAAGATAAAAAGTAGTTCTGGATTTAAAGAAT
TATCCGTTTGTTTTTCCAAAATACTTTATTCTCTCATACATAGTATTTTCATAATGTTTGACATGCAGTGCTTCTTTCTGTAATTTTGAC

>7330_7330_1_ATAD1-LIPF_ATAD1_chr10_89550066_ENST00000328142_LIPF_chr10_90427043_ENST00000394375_length(amino acids)=539AA_BP=176
MFVFLRLTFKMVHAEAFSRPLSRNEVVGLIFRLTIFGAVTYFTIKWMVDAIDPTRKQKVEAQKQAEKLMKQIGVKNVKLSEYEMSIAAHL
VDPLNMHVTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPPKGRSKMWLLLTMASLISVLGTTHGLFGKLHPGSPEVTMNISQMI
TYWGYPNEEYEVVTEDGYILEVNRIPYGKKNSGNTGQRPVVFLQHGLLASATNWISNLPNNSLAFILADAGYDVWLGNSRGNTWARRNLY
YSPDSVEFWAFSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIGFIAFSTNPSLAKRIKTFYALAPVATVKYTKSLINKLRFVPQ
SLFKFIFGDKIFYPHNFFDQFLATEVCSREMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTSVQNMFHWTQAVKSGKFQAYDWG

--------------------------------------------------------------
>7330_7330_2_ATAD1-LIPF_ATAD1_chr10_89550066_ENST00000400215_LIPF_chr10_90427043_ENST00000394375_length(transcript)=1560nt_BP=222nt
AGGCAGAAAAACTAATGAAGCAAATTGGAGTGAAAAATGTGAAGCTCTCAGAATATGAAATGAGTATTGCTGCTCATCTTGTAGACCCTC
TTAATATGCATGTTACTTGGAGTGATATAGCAGGTTTAGATGATGTCATTACGGATCTGAAAGACACAGTCATCTTACCTATCAAAAAGA
AACATTTGTTTGAGAATTCCAGGCTTCTGCAGCCTCCAAAAGGCAGGTCCAAAATGTGGCTGCTTTTAACAATGGCAAGTTTGATATCTG
TACTGGGGACTACACATGGTTTGTTTGGAAAATTACATCCTGGAAGCCCTGAAGTGACTATGAACATTAGTCAGATGATTACTTATTGGG
GATACCCAAATGAAGAATATGAAGTTGTGACTGAAGATGGTTATATTCTTGAAGTCAATAGAATTCCTTATGGGAAGAAAAATTCAGGGA
ATACAGGCCAGAGACCTGTTGTGTTTTTGCAGCATGGTTTGCTTGCATCAGCCACAAACTGGATTTCCAACCTGCCGAACAACAGCCTTG
CCTTCATTCTGGCAGATGCTGGTTATGATGTGTGGCTGGGCAACAGCAGAGGAAACACCTGGGCCAGAAGAAACTTGTACTATTCACCAG
ATTCAGTTGAATTCTGGGCTTTCAGCTTTGATGAAATGGCTAAATATGACCTTCCAGCCACAATCGACTTCATTGTAAAGAAAACTGGAC
AGAAGCAGCTACACTATGTTGGCCATTCCCAGGGCACCACCATTGGTTTTATTGCCTTTTCCACCAATCCCAGCCTGGCTAAAAGAATCA
AAACCTTCTATGCTCTAGCTCCTGTTGCCACTGTGAAGTATACAAAAAGCCTTATAAACAAACTTAGATTTGTTCCTCAATCCCTCTTCA
AGTTTATATTTGGTGACAAAATATTCTACCCACACAACTTCTTTGATCAATTTCTTGCTACTGAAGTGTGCTCCCGTGAGATGCTGAATC
TCCTTTGCAGCAATGCCTTATTTATAATTTGTGGATTTGACAGTAAGAACTTTAACACGAGTCGCTTGGATGTGTATCTATCACATAATC
CAGCAGGAACTTCTGTTCAAAACATGTTCCATTGGACCCAGGCTGTTAAGTCTGGGAAATTCCAAGCTTATGACTGGGGAAGCCCAGTTC
AGAATAGGATGCACTATGATCAGTCCCAACCTCCCTACTACAATGTGACAGCCATGAATGTACCAATTGCAGTGTGGAACGGTGGCAAGG
ACCTGTTGGCTGACCCCCAAGATGTTGGCCTTTTGCTTCCAAAACTCCCCAATCTTATTTACCACAAGGAGATTCCTTTTTACAATCACT
TGGACTTTATCTGGGCAATGGATGCCCCTCAAGAAGTTTACAATGACATTGTTTCTATGATATCAGAAGATAAAAAGTAGTTCTGGATTT
AAAGAATTATCCGTTTGTTTTTCCAAAATACTTTATTCTCTCATACATAGTATTTTCATAATGTTTGACATGCAGTGCTTCTTTCTGTAA

>7330_7330_2_ATAD1-LIPF_ATAD1_chr10_89550066_ENST00000400215_LIPF_chr10_90427043_ENST00000394375_length(amino acids)=471AA_BP=108
MKQIGVKNVKLSEYEMSIAAHLVDPLNMHVTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPPKGRSKMWLLLTMASLISVLGTT
HGLFGKLHPGSPEVTMNISQMITYWGYPNEEYEVVTEDGYILEVNRIPYGKKNSGNTGQRPVVFLQHGLLASATNWISNLPNNSLAFILA
DAGYDVWLGNSRGNTWARRNLYYSPDSVEFWAFSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIGFIAFSTNPSLAKRIKTFYA
LAPVATVKYTKSLINKLRFVPQSLFKFIFGDKIFYPHNFFDQFLATEVCSREMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTS
VQNMFHWTQAVKSGKFQAYDWGSPVQNRMHYDQSQPPYYNVTAMNVPIAVWNGGKDLLADPQDVGLLLPKLPNLIYHKEIPFYNHLDFIW

--------------------------------------------------------------
>7330_7330_3_ATAD1-LIPF_ATAD1_chr10_89550067_ENST00000328142_LIPF_chr10_90427044_ENST00000394375_length(transcript)=2003nt_BP=665nt
GTATTTTTCAAATAAAATGATTAATTCTACTACCAAATAAATCTTAATTTCTAGTCTACTTCTAGTTTGCAAGAGGAGCTTTAAATGTAT
TTGTTTACTTAACATTTAAAAATCCATTTCTCCTTAAAATGAAACACTTTTTTTAAGGTAGGTAATATTTTAATTTGACTAGAAGTTAGT
TTTTCTTTCTTAGTTTAAGCTACTTTGTTAGTCTTACAATTTTAATAAGTATAGTTATTACCTAGTGACATTTCTGTTTGTTTTTTTAAG
GTTAACATTCAAGATGGTACATGCTGAAGCCTTTTCTCGTCCTTTGAGTCGGAATGAAGTTGTTGGTTTAATTTTCCGTTTGACAATATT
TGGTGCAGTGACATACTTTACTATCAAATGGATGGTAGATGCAATTGATCCAACCAGAAAGCAAAAAGTAGAAGCTCAGAAACAGGCAGA
AAAACTAATGAAGCAAATTGGAGTGAAAAATGTGAAGCTCTCAGAATATGAAATGAGTATTGCTGCTCATCTTGTAGACCCTCTTAATAT
GCATGTTACTTGGAGTGATATAGCAGGTTTAGATGATGTCATTACGGATCTGAAAGACACAGTCATCTTACCTATCAAAAAGAAACATTT
GTTTGAGAATTCCAGGCTTCTGCAGCCTCCAAAAGGCAGGTCCAAAATGTGGCTGCTTTTAACAATGGCAAGTTTGATATCTGTACTGGG
GACTACACATGGTTTGTTTGGAAAATTACATCCTGGAAGCCCTGAAGTGACTATGAACATTAGTCAGATGATTACTTATTGGGGATACCC
AAATGAAGAATATGAAGTTGTGACTGAAGATGGTTATATTCTTGAAGTCAATAGAATTCCTTATGGGAAGAAAAATTCAGGGAATACAGG
CCAGAGACCTGTTGTGTTTTTGCAGCATGGTTTGCTTGCATCAGCCACAAACTGGATTTCCAACCTGCCGAACAACAGCCTTGCCTTCAT
TCTGGCAGATGCTGGTTATGATGTGTGGCTGGGCAACAGCAGAGGAAACACCTGGGCCAGAAGAAACTTGTACTATTCACCAGATTCAGT
TGAATTCTGGGCTTTCAGCTTTGATGAAATGGCTAAATATGACCTTCCAGCCACAATCGACTTCATTGTAAAGAAAACTGGACAGAAGCA
GCTACACTATGTTGGCCATTCCCAGGGCACCACCATTGGTTTTATTGCCTTTTCCACCAATCCCAGCCTGGCTAAAAGAATCAAAACCTT
CTATGCTCTAGCTCCTGTTGCCACTGTGAAGTATACAAAAAGCCTTATAAACAAACTTAGATTTGTTCCTCAATCCCTCTTCAAGTTTAT
ATTTGGTGACAAAATATTCTACCCACACAACTTCTTTGATCAATTTCTTGCTACTGAAGTGTGCTCCCGTGAGATGCTGAATCTCCTTTG
CAGCAATGCCTTATTTATAATTTGTGGATTTGACAGTAAGAACTTTAACACGAGTCGCTTGGATGTGTATCTATCACATAATCCAGCAGG
AACTTCTGTTCAAAACATGTTCCATTGGACCCAGGCTGTTAAGTCTGGGAAATTCCAAGCTTATGACTGGGGAAGCCCAGTTCAGAATAG
GATGCACTATGATCAGTCCCAACCTCCCTACTACAATGTGACAGCCATGAATGTACCAATTGCAGTGTGGAACGGTGGCAAGGACCTGTT
GGCTGACCCCCAAGATGTTGGCCTTTTGCTTCCAAAACTCCCCAATCTTATTTACCACAAGGAGATTCCTTTTTACAATCACTTGGACTT
TATCTGGGCAATGGATGCCCCTCAAGAAGTTTACAATGACATTGTTTCTATGATATCAGAAGATAAAAAGTAGTTCTGGATTTAAAGAAT
TATCCGTTTGTTTTTCCAAAATACTTTATTCTCTCATACATAGTATTTTCATAATGTTTGACATGCAGTGCTTCTTTCTGTAATTTTGAC

>7330_7330_3_ATAD1-LIPF_ATAD1_chr10_89550067_ENST00000328142_LIPF_chr10_90427044_ENST00000394375_length(amino acids)=539AA_BP=176
MFVFLRLTFKMVHAEAFSRPLSRNEVVGLIFRLTIFGAVTYFTIKWMVDAIDPTRKQKVEAQKQAEKLMKQIGVKNVKLSEYEMSIAAHL
VDPLNMHVTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPPKGRSKMWLLLTMASLISVLGTTHGLFGKLHPGSPEVTMNISQMI
TYWGYPNEEYEVVTEDGYILEVNRIPYGKKNSGNTGQRPVVFLQHGLLASATNWISNLPNNSLAFILADAGYDVWLGNSRGNTWARRNLY
YSPDSVEFWAFSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIGFIAFSTNPSLAKRIKTFYALAPVATVKYTKSLINKLRFVPQ
SLFKFIFGDKIFYPHNFFDQFLATEVCSREMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTSVQNMFHWTQAVKSGKFQAYDWG

--------------------------------------------------------------
>7330_7330_4_ATAD1-LIPF_ATAD1_chr10_89550067_ENST00000400215_LIPF_chr10_90427044_ENST00000394375_length(transcript)=1560nt_BP=222nt
AGGCAGAAAAACTAATGAAGCAAATTGGAGTGAAAAATGTGAAGCTCTCAGAATATGAAATGAGTATTGCTGCTCATCTTGTAGACCCTC
TTAATATGCATGTTACTTGGAGTGATATAGCAGGTTTAGATGATGTCATTACGGATCTGAAAGACACAGTCATCTTACCTATCAAAAAGA
AACATTTGTTTGAGAATTCCAGGCTTCTGCAGCCTCCAAAAGGCAGGTCCAAAATGTGGCTGCTTTTAACAATGGCAAGTTTGATATCTG
TACTGGGGACTACACATGGTTTGTTTGGAAAATTACATCCTGGAAGCCCTGAAGTGACTATGAACATTAGTCAGATGATTACTTATTGGG
GATACCCAAATGAAGAATATGAAGTTGTGACTGAAGATGGTTATATTCTTGAAGTCAATAGAATTCCTTATGGGAAGAAAAATTCAGGGA
ATACAGGCCAGAGACCTGTTGTGTTTTTGCAGCATGGTTTGCTTGCATCAGCCACAAACTGGATTTCCAACCTGCCGAACAACAGCCTTG
CCTTCATTCTGGCAGATGCTGGTTATGATGTGTGGCTGGGCAACAGCAGAGGAAACACCTGGGCCAGAAGAAACTTGTACTATTCACCAG
ATTCAGTTGAATTCTGGGCTTTCAGCTTTGATGAAATGGCTAAATATGACCTTCCAGCCACAATCGACTTCATTGTAAAGAAAACTGGAC
AGAAGCAGCTACACTATGTTGGCCATTCCCAGGGCACCACCATTGGTTTTATTGCCTTTTCCACCAATCCCAGCCTGGCTAAAAGAATCA
AAACCTTCTATGCTCTAGCTCCTGTTGCCACTGTGAAGTATACAAAAAGCCTTATAAACAAACTTAGATTTGTTCCTCAATCCCTCTTCA
AGTTTATATTTGGTGACAAAATATTCTACCCACACAACTTCTTTGATCAATTTCTTGCTACTGAAGTGTGCTCCCGTGAGATGCTGAATC
TCCTTTGCAGCAATGCCTTATTTATAATTTGTGGATTTGACAGTAAGAACTTTAACACGAGTCGCTTGGATGTGTATCTATCACATAATC
CAGCAGGAACTTCTGTTCAAAACATGTTCCATTGGACCCAGGCTGTTAAGTCTGGGAAATTCCAAGCTTATGACTGGGGAAGCCCAGTTC
AGAATAGGATGCACTATGATCAGTCCCAACCTCCCTACTACAATGTGACAGCCATGAATGTACCAATTGCAGTGTGGAACGGTGGCAAGG
ACCTGTTGGCTGACCCCCAAGATGTTGGCCTTTTGCTTCCAAAACTCCCCAATCTTATTTACCACAAGGAGATTCCTTTTTACAATCACT
TGGACTTTATCTGGGCAATGGATGCCCCTCAAGAAGTTTACAATGACATTGTTTCTATGATATCAGAAGATAAAAAGTAGTTCTGGATTT
AAAGAATTATCCGTTTGTTTTTCCAAAATACTTTATTCTCTCATACATAGTATTTTCATAATGTTTGACATGCAGTGCTTCTTTCTGTAA

>7330_7330_4_ATAD1-LIPF_ATAD1_chr10_89550067_ENST00000400215_LIPF_chr10_90427044_ENST00000394375_length(amino acids)=471AA_BP=108
MKQIGVKNVKLSEYEMSIAAHLVDPLNMHVTWSDIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPPKGRSKMWLLLTMASLISVLGTT
HGLFGKLHPGSPEVTMNISQMITYWGYPNEEYEVVTEDGYILEVNRIPYGKKNSGNTGQRPVVFLQHGLLASATNWISNLPNNSLAFILA
DAGYDVWLGNSRGNTWARRNLYYSPDSVEFWAFSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIGFIAFSTNPSLAKRIKTFYA
LAPVATVKYTKSLINKLRFVPQSLFKFIFGDKIFYPHNFFDQFLATEVCSREMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTS
VQNMFHWTQAVKSGKFQAYDWGSPVQNRMHYDQSQPPYYNVTAMNVPIAVWNGGKDLLADPQDVGLLLPKLPNLIYHKEIPFYNHLDFIW

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ATAD1-LIPF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATAD1-LIPF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneLIPFP07098DB01083OrlistatInhibitorSmall moleculeApproved|Investigational

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Related Diseases for ATAD1-LIPF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATAD1C4693933HYPEREKPLEXIA 43GENOMICS_ENGLAND;UNIPROT
HgeneATAD1C1835614Hereditary Hyperexplexia1ORPHANET