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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:RITA1-GRHL2 (FusionGDB2 ID:HG84934TG79977) |
Fusion Gene Summary for RITA1-GRHL2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: RITA1-GRHL2 | Fusion gene ID: hg84934tg79977 | Hgene | Tgene | Gene symbol | RITA1 | GRHL2 | Gene ID | 84934 | 79977 |
| Gene name | RBPJ interacting and tubulin associated 1 | grainyhead like transcription factor 2 | |
| Synonyms | C12orf52|RITA | BOM|DFNA28|ECTDS|PPCD4|TFCP2L3 | |
| Cytomap | ('C12orf52','RITA1')('GRHL2','GRHL2') 12q24.13 | 8q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RBPJ-interacting and tubulin-associated protein 1 | grainyhead-like protein 2 homologbrother of mammalian grainyheadgrainyhead-like 2transcription factor CP2-like 3 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000548278, ENST00000549621, ENST00000552495, | ||
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 8 X 8 X 5=320 |
| # samples | 1 | 8 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(8/320*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: RITA1 [Title/Abstract] AND GRHL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | C12orf52(113624853)-GRHL2(102555469), # samples:2 RITA1(113624853)-GRHL2(102555469), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | C12orf52-GRHL2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. C12orf52-GRHL2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. C12orf52-GRHL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. C12orf52-GRHL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | RITA1 | GO:0045746 | negative regulation of Notch signaling pathway | 21102556 |
| Hgene | RITA1 | GO:0051168 | nuclear export | 21102556 |
| Tgene | GRHL2 | GO:0008544 | epidermis development | 23254293 |
| Tgene | GRHL2 | GO:0044030 | regulation of DNA methylation | 23254293 |
| Tgene | GRHL2 | GO:0045617 | negative regulation of keratinocyte differentiation | 23254293 |
| Tgene | GRHL2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 23814079 |
| Fusion gene breakpoints across C12orf52 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across GRHL2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | HNSC | TCGA-CV-7253-01A | C12orf52 | chr12 | 113624853 | - | GRHL2 | chr8 | 102555469 | + |
| ChimerDB4 | HNSC | TCGA-CV-7253 | C12orf52 | chr12 | 113624853 | + | GRHL2 | chr8 | 102555469 | + |
| ChimerDB4 | HNSC | TCGA-CV-7253-01A | RITA1 | chr12 | 113624853 | + | GRHL2 | chr8 | 102555469 | + |
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Fusion Gene ORF analysis for RITA1-GRHL2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000548278 | ENST00000395927 | C12orf52 | chr12 | 113624853 | + | GRHL2 | chr8 | 102555469 | + |
| 5CDS-5UTR | ENST00000549621 | ENST00000395927 | C12orf52 | chr12 | 113624853 | + | GRHL2 | chr8 | 102555469 | + |
| 5CDS-5UTR | ENST00000552495 | ENST00000395927 | C12orf52 | chr12 | 113624853 | + | GRHL2 | chr8 | 102555469 | + |
| 5CDS-intron | ENST00000548278 | ENST00000517674 | C12orf52 | chr12 | 113624853 | + | GRHL2 | chr8 | 102555469 | + |
| 5CDS-intron | ENST00000549621 | ENST00000517674 | C12orf52 | chr12 | 113624853 | + | GRHL2 | chr8 | 102555469 | + |
| 5CDS-intron | ENST00000552495 | ENST00000517674 | C12orf52 | chr12 | 113624853 | + | GRHL2 | chr8 | 102555469 | + |
| In-frame | ENST00000548278 | ENST00000251808 | C12orf52 | chr12 | 113624853 | + | GRHL2 | chr8 | 102555469 | + |
| In-frame | ENST00000549621 | ENST00000251808 | C12orf52 | chr12 | 113624853 | + | GRHL2 | chr8 | 102555469 | + |
| In-frame | ENST00000552495 | ENST00000251808 | C12orf52 | chr12 | 113624853 | + | GRHL2 | chr8 | 102555469 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000549621 | C12orf52 | chr12 | 113624853 | + | ENST00000251808 | GRHL2 | chr8 | 102555469 | + | 5867 | 986 | 639 | 2843 | 734 |
| ENST00000548278 | C12orf52 | chr12 | 113624853 | + | ENST00000251808 | GRHL2 | chr8 | 102555469 | + | 5875 | 994 | 647 | 2851 | 734 |
| ENST00000552495 | C12orf52 | chr12 | 113624853 | + | ENST00000251808 | GRHL2 | chr8 | 102555469 | + | 5727 | 846 | 472 | 2703 | 743 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000549621 | ENST00000251808 | C12orf52 | chr12 | 113624853 | + | GRHL2 | chr8 | 102555469 | + | 0.000578085 | 0.99942195 |
| ENST00000548278 | ENST00000251808 | C12orf52 | chr12 | 113624853 | + | GRHL2 | chr8 | 102555469 | + | 0.00057193 | 0.9994281 |
| ENST00000552495 | ENST00000251808 | C12orf52 | chr12 | 113624853 | + | GRHL2 | chr8 | 102555469 | + | 0.000740906 | 0.99925905 |
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Fusion Genomic Features for RITA1-GRHL2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| C12orf52 | chr12 | 113624853 | + | GRHL2 | chr8 | 102555468 | + | 1.80E-08 | 1 |
| C12orf52 | chr12 | 113624853 | + | GRHL2 | chr8 | 102555468 | + | 1.80E-08 | 1 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for RITA1-GRHL2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:113624853/:102555469) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | GRHL2 | chr12:113624853 | chr8:102555469 | ENST00000395927 | 0 | 16 | 1_93 | 0 | 610.0 | Region | Transcription activation |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | GRHL2 | chr12:113624853 | chr8:102555469 | ENST00000251808 | 0 | 16 | 1_93 | 6 | 626.0 | Region | Transcription activation |
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Fusion Gene Sequence for RITA1-GRHL2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >10859_10859_1_C12orf52-GRHL2_C12orf52_chr12_113624853_ENST00000548278_GRHL2_chr8_102555469_ENST00000251808_length(transcript)=5875nt_BP=994nt GCGGTGACCACGTGACCTCCGCTGAGCTTTCGCCAGTGCCTGCGGCCCTCGGCGGCCTAGTACACACGCACCTGAGTGAGTGGCACCAGA GGACCCTCTCCATGTTTAGGGACCTCCTGGGCCTCAGGAGCGTGGCGCCCGCCCCTGGGCGGACTCCCCCCATCCGCGGGCGCGAATGGT CCGGGCCGCGTCCGCAGTGCTGCTGGCTGCTCCCTGGTTGCTGGGTGCAAAGTGCTGGGTTCTGGGTTTCTGGATTCGCGGGCCGTTCAC ACGTAGCCTGTGCCGGCTCCTCGGGTGAGTCCGTCCGCGCGCGGTGCCCCGGGACGGCCTAGGCTGCCGGGGGTCCGGGGCCCCAGGCAT TCCGGGCTGCAGATTGACGGGGATCCCGGATGCACCGCGCGCCCCCGCGCCCTCACCGACGGGTCCAGACCTGGTGGGAAGAAGGTGCGG GGACGGGTCCCTGAGGATCCCGATGCCTACGAGCCAAGATGCTCAGCTTTATAGGTGTGACCTACACATGTGACTTCACCTCAGTTTTGT GATCCGTAAAATGGACAAATTCGAAGCTACTTCACAGTGCTGTTGAGAGGATTAAATGAAACAATGCTTGTAAAGCTCTTTGCAGGAGGG AGCCTCGGAAGCAGGGCCTGGCCGGCAGAGCACACCTGCTGTCACCAGGGACCACAGGCAGCATGAAGACCCCCGTGGAGCTGGCCGTCA GTGGGATGCAGACCCTCGGCCTTCAGCACCGCTGCCGAGGTGGCTACCGGGTCAAGGCCAGGACGTCATATGTGGATGAGACTCTGTTTG GCAGCCCAGCAGGCACCCGGCCTACCCCACCGGACTTCGATCCGCCCTGGGTGGAGAAGGCTAACAGAACCAGAGGCGTGGGCAAGGAGG CATCGAAGGCCTTGGGGGCAAAGGGGAGCTGTGAGACCACCCCCTCAAGGGGCAGCACCCCCACCCTCACACCAAGGAAGAAGAACAAAT ACAGTAATAAAAGACTAGTGGCCTTAGTGCCCATGCCCAGTGACCCTCCATTCAATACCCGAAGAGCCTACACCAGTGAGGATGAAGCCT GGAAGTCATACTTGGAGAATCCCCTGACAGCAGCCACCAAGGCCATGATGAGCATTAATGGTGATGAGGACAGTGCTGCTGCCCTCGGCC TGCTCTATGACTACTACAAGGTTCCTCGAGACAAGAGGCTGCTGTCTGTAAGCAAAGCAAGTGACAGCCAAGAAGACCAGGAGAAAAGAA ACTGCCTTGGCACCAGTGAAGCCCAGAGTAATTTGAGTGGAGGAGAAAACCGAGTGCAAGTCCTAAAGACTGTTCCAGTGAACCTTTCCC TAAATCAAGATCACCTGGAGAATTCCAAGCGGGAACAGTACAGCATCAGCTTCCCCGAGAGCTCTGCCATCATCCCGGTGTCGGGAATCA CGGTGGTGAAAGCTGAAGATTTCACACCAGTTTTCATGGCCCCACCTGTGCACTATCCCCGGGGAGATGGGGAAGAGCAACGAGTGGTTA TCTTTGAACAGACTCAGTATGACGTGCCCTCGCTGGCCACCCACAGCGCCTATCTCAAAGACGACCAGCGCAGCACTCCGGACAGCACAT ACAGCGAGAGCTTCAAGGACGCAGCCACAGAGAAATTTCGGAGTGCTTCAGTTGGGGCTGAGGAGTACATGTATGATCAGACATCAAGTG GCACATTTCAGTACACCCTGGAAGCCACCAAATCTCTCCGTCAGAAGCAGGGGGAGGGCCCCATGACCTACCTCAACAAAGGACAGTTCT ATGCCATAACACTCAGCGAGACCGGAGACAACAAATGCTTCCGACACCCCATCAGCAAAGTCAGGAGTGTGGTGATGGTGGTCTTCAGTG AAGACAAAAACAGAGATGAACAGCTCAAATACTGGAAATACTGGCACTCTCGGCAGCATACGGCGAAGCAGAGGGTCCTTGACATTGCCG ATTACAAGGAGAGCTTTAATACGATTGGAAACATTGAAGAGATTGCATATAATGCTGTTTCCTTTACCTGGGACGTGAATGAAGAGGCGA AGATTTTCATCACCGTGAATTGCTTGAGCACAGATTTCTCCTCCCAAAAAGGGGTGAAAGGACTTCCTTTGATGATTCAGATTGACACAT ACAGTTATAACAATCGTAGCAATAAACCCATTCATAGAGCTTATTGCCAGATCAAGGTCTTCTGTGACAAAGGAGCAGAAAGAAAAATCC GAGATGAAGAGCGGAAGCAGAACAGGAAGAAAGGGAAAGGCCAGGCCTCCCAAACTCAATGCAACAGCTCCTCTGATGGGAAGTTGGCTG CCATACCTTTACAGAAGAAGAGTGACATCACCTACTTCAAAACCATGCCTGATCTCCACTCACAGCCAGTTCTCTTCATACCTGATGTTC ACTTTGCAAACCTGCAGAGGACCGGACAGGTGTATTACAACACGGATGATGAACGAGAAGGTGGCAGTGTCCTTGTTAAACGGATGTTCC GGCCCATGGAAGAGGAGTTTGGTCCAGTGCCTTCAAAGCAGATGAAAGAAGAAGGGACAAAGCGAGTGCTCTTGTACGTGAGGAAGGAGA CTGACGATGTGTTCGATGCATTGATGTTGAAGTCTCCCACAGTGAAGGGCCTGATGGAAGCGATATCTGAGAAATATGGGCTGCCCGTGG AGAAGATAGCAAAGCTTTACAAGAAAAGCAAAAAAGGCATCTTGGTGAACATGGATGACAACATCATCGAGCACTACTCGAACGAGGACA CCTTCATCCTCAACATGGAGAGCATGGTGGAGGGCTTCAAGGTCACGCTCATGGAAATCTAGCCCTGGGTTTGGCATCCGCTTTGGCTGG AGCTCTCAGTGCGTTCCTCCCTGAGAGAGACAGAAGCCCCAGCCCCAGAACCTGGAGACCCATCTCCCCCATCTCACAACTGCTGTTACA AGACCGTGCTGGGGAGTGGGGCAAGGGACAGGCCCCACTGTCGGTGTGCTTGGCCCATCCACTGGCACCTACCACGGAGCTGAAGCCTGA GCCCCTCAGGAAGGTGCCTTAGGCCTGTTGGATTCCTATTTATTGCCCACCTTTTCCTGGAGCCCAGGTCCAGGCCCGCCAGGACTCTGC AGGTCACTGCTAGCTCCAGATGAGACCGTCCAGCGTTCCCCCTTCAAGAGAAACACTCATCCCGAACAGCCTAAAAAATTCCCATCCCTT CTCTCTCACCCCTCCATATCTATCTCCCGAGTGGCTGGACAAAATGAGCTACGTCTGGGTGCAGTAGTTATAGGTGGGGCAAGAGGTGGA TGCCCACTTTCTGGTCAGACACCTTTAGGTTGCTCTGGGGAAGGCTGTCTTGCTAAATACCTCCAGGGTTCCCAGCAAGTGGCCACCAGG CCTTGTACAGGAAGACATTCAGTCACCGTGTAATTAGTAACACAGAAAGTCTGCCTGTCTGCATTGTACATAGTGTTTATAATATTGTAA TAATATATTTTACCTGTGGTATGTGGGCATGTTTACTGCCACTGGCCTAGAGGAGACACAGACCTGGAGACCGTTTTAATGGGGGTTTTT GCCTCTGTGCCTGTTCAAGAGACTTGCAGGGCTAGGTAGAGGGCCTTTGGGATGTTAAGGTGACTGCAGCTGATGCCAAGATGGACTCTG CAATGGGCATACCTGGGGGCTCGTTCCCTGTCCCCAGAGGAAGCCCCCTCTCCTTCTCCATGGGCATGACTCTCCTTCGAGGCCACCACG TTTATCTCACAATGATGTGTTTTGCTTGACTTTCCCTTTGCGCTGTCTCGTGGGAAAGGTCATTCTGTCTGAGACCCCAGCTCCTTCTCC AGCTTTGGCTGCGGGCATGGCCTGAGCTTTCTGGAGAGCCTCTGCAGGGGGTTTGCCATCAGGGCCCTGTGGCTGGGTCTGCTGCAGAGC TCCTTGGCTATCAGGAGAATCCTGGACACTGTACTGTGCCTCCCAGTTTACAAACACGCCCTTCATCTCAAGTGGCCCTTTAAAAGGCCT GCTGCCATGTGAGAGCTGTGAACAGCTCAGCTCTGAGTCGGCAGGCTGGGGCTTCCTCCTGGGCCACCAGATGGAAAGGGGGTATTGTTT GCCTCACTCCTGGATGCTGCGTTTTAAGGAAGTGAGTGAGAAAGAATGTGCCAAGATACCTGGCTCCTGTGAAACCAGCCTCAGGAGGGA AACTGGGAGAGAGAAGCTGTGGTCTCCTGCTACATGCCCTGGGAGCTGGAAGAGAAAAACACTCCCCTAAACAATCGCAAAATGATGAAC CATCATGGGCCACTGTTCTCTTTGAGGGGACAGGTTTAGGGGTTTGCGTTCGCCCTTGTGGGCTGAAGCACTAGCTTTTTGGTAGCTAGA CACATCCTGCACCCAAAGGTTCTCTACAAAGGCCCAGATTTGTTTGTAAAGCACTTTGACTCTTACCTGGAGGCCCGCTCTCTAAGGGCT TCCTGCGCTCCCACCTCATCTGTCCCTGAGATGCAGAGCAGGATGGAGGGTCTGCTTCTAGCTCAGCTGTTTCTCCTTGAGGTTGCGGAG GAATTGAATTGAATGGGACAGAGGGCAGGTGCTGTGGCCAAGAAGATCTCCGAGCAGCAGTGACGGGGCACCTTGCTGTGTGTCCTCTGG GCATGTTAACCCTTCTGTGGGGCCAAAGGTTTGCATCGTGGATCCAGCTGTGCTCCAGTCTGTCCCCTCCTCCTCCACTCTGACTGCCAC GCCCCGGACCAGCAGCTTGGGGACCCTCCAGGGTACTAATGGGGCTCTGTTCTGAGATGGACAAATTCAGTGTTGGAAATACATGTTGTA CTATGCACTTCCCATGCTCCTAGGGTTAGGAATAGTTTCAAACATGATTGGCAGACATAACAACGGCAAATACTCGGACTGGGGCATAGG ACTCCAGAGTAGGAAAAAGACAAAAGATTTGGCAGCCTGACACAGGCAACCTACCCCTCTCTCTCCAGCCTCTTTATGAAACTGTTTGTT TGCCAGTCCTGCCCTAAGGCAGAAGATGAATTGAAGATGCTGTGCATGTTTCCTAAGTCCTTGAGCAATCATGGTGGTGACAATTGCCAC AAGGGATATGAGGCCAGTGCCACCAGAGGGTGGTGCCAAGTGCCACATCCCTTCCGATCCATTCCCCTCTGCATCCTCGGAGCACCCCAG TTTGCCTTTGATGTGTCCGCTGTGTATGTTAGCTGAACTTTGATGAGCAAAATTTCCTGAGCGAAACACTCCAAAGAGATAGGAAAACTT GCCGCCTCTTCTTTTTTGTCCCTTAATCAAACTCAAATAAGCTTAAAAAAAATCCATGGAAGATCATGGACATGTGAAATGAGCATTTTT TTCTTTTTTTTTTTTAACAAAGTCTGAACTGAACAGAACAAGACTTTTTCCTCATACATCTCCAAATTGTTTAAACTTACTTTATGAGTG TTTGTTTAGAAGTTCGGACCAACAGAAAAATGCAGTCAGATGTCATCTTGGAATTGGTTTCTAAAAGAGTAAGGCATGTCCCTGCCCAGA AACTTAGGAAGCATGAAATAAATCAAATGTTTATTTTCCTTCTTATTTAAAATCATGCAAATGCAACAGAAATAGAGGGTTTGTGCCAAA TGCTATGAACGGCCCTTTCTTAAAGACAAGCAAGGGAGATTGATATATGTACAATTTGCTCTCATGTTTTAAAAAAAAAAAGGTAAATGT AACTTAATAGTTTTGTAAATGGGAGAGGGGGAATCTATAAACTATAAATACAGTTATTTTATTTTTTGTACATTTTTAAGGAGAAAAAAT >10859_10859_1_C12orf52-GRHL2_C12orf52_chr12_113624853_ENST00000548278_GRHL2_chr8_102555469_ENST00000251808_length(amino acids)=734AA_BP=114 MAGRAHLLSPGTTGSMKTPVELAVSGMQTLGLQHRCRGGYRVKARTSYVDETLFGSPAGTRPTPPDFDPPWVEKANRTRGVGKEASKALG AKGSCETTPSRGSTPTLTPRKKNKYSNKRLVALVPMPSDPPFNTRRAYTSEDEAWKSYLENPLTAATKAMMSINGDEDSAAALGLLYDYY KVPRDKRLLSVSKASDSQEDQEKRNCLGTSEAQSNLSGGENRVQVLKTVPVNLSLNQDHLENSKREQYSISFPESSAIIPVSGITVVKAE DFTPVFMAPPVHYPRGDGEEQRVVIFEQTQYDVPSLATHSAYLKDDQRSTPDSTYSESFKDAATEKFRSASVGAEEYMYDQTSSGTFQYT LEATKSLRQKQGEGPMTYLNKGQFYAITLSETGDNKCFRHPISKVRSVVMVVFSEDKNRDEQLKYWKYWHSRQHTAKQRVLDIADYKESF NTIGNIEEIAYNAVSFTWDVNEEAKIFITVNCLSTDFSSQKGVKGLPLMIQIDTYSYNNRSNKPIHRAYCQIKVFCDKGAERKIRDEERK QNRKKGKGQASQTQCNSSSDGKLAAIPLQKKSDITYFKTMPDLHSQPVLFIPDVHFANLQRTGQVYYNTDDEREGGSVLVKRMFRPMEEE FGPVPSKQMKEEGTKRVLLYVRKETDDVFDALMLKSPTVKGLMEAISEKYGLPVEKIAKLYKKSKKGILVNMDDNIIEHYSNEDTFILNM -------------------------------------------------------------- >10859_10859_2_C12orf52-GRHL2_C12orf52_chr12_113624853_ENST00000549621_GRHL2_chr8_102555469_ENST00000251808_length(transcript)=5867nt_BP=986nt GCGGTGACCACGTGACCTCCGCTGAGCTTTCGCCAGTGCCTGCGGCCCTCGGCGGCCTAGTACACACGCACCTGAGTGAGTGGCACCAGA GGACCCTCTCCATGTTTAGGGACCTCCTGGGCCTCAGGAGCGTGGCGCCCGCCCCTGGGCGGACTCCCCCCATCCGCGGGCGCGAATGGT CCGGGCCGCGTCCGCAGTGCTGCTGGCTGCTCCCTGGTTGCTGGGTGCAAAGTGCTGGGTTCTGGGTTTCTGGATTCGCGGGCCGTTCAC ACGTAGCCTGTGCCGGCTCCTCGGGTGAGTCCGTCCGCGCGCGGTGCCCCGGGACGGCCTAGGCTGCCGGGGGTCCGGGGCCCCAGGCAT TCCGGGCTGCAGATTGACGGGGATCCCGGATGCACCGCGCGCCCCCGCGCCCTCACCGACGGGTCCAGACCTGGTGGGAAGAAGGTGCGG GGACGGGTCCCTGAGGATCCCGATGCCTACGAGCCAAGATGCTCAGGTGTGACCTACACATGTGACTTCACCTCAGTTTTGTGATCCGTA AAATGGACAAATTCGAAGCTACTTCACAGTGCTGTTGAGAGGATTAAATGAAACAATGCTTGTAAAGCTCTTTGCAGGAGGGAGCCTCGG AAGCAGGGCCTGGCCGGCAGAGCACACCTGCTGTCACCAGGGACCACAGGCAGCATGAAGACCCCCGTGGAGCTGGCCGTCAGTGGGATG CAGACCCTCGGCCTTCAGCACCGCTGCCGAGGTGGCTACCGGGTCAAGGCCAGGACGTCATATGTGGATGAGACTCTGTTTGGCAGCCCA GCAGGCACCCGGCCTACCCCACCGGACTTCGATCCGCCCTGGGTGGAGAAGGCTAACAGAACCAGAGGCGTGGGCAAGGAGGCATCGAAG GCCTTGGGGGCAAAGGGGAGCTGTGAGACCACCCCCTCAAGGGGCAGCACCCCCACCCTCACACCAAGGAAGAAGAACAAATACAGTAAT AAAAGACTAGTGGCCTTAGTGCCCATGCCCAGTGACCCTCCATTCAATACCCGAAGAGCCTACACCAGTGAGGATGAAGCCTGGAAGTCA TACTTGGAGAATCCCCTGACAGCAGCCACCAAGGCCATGATGAGCATTAATGGTGATGAGGACAGTGCTGCTGCCCTCGGCCTGCTCTAT GACTACTACAAGGTTCCTCGAGACAAGAGGCTGCTGTCTGTAAGCAAAGCAAGTGACAGCCAAGAAGACCAGGAGAAAAGAAACTGCCTT GGCACCAGTGAAGCCCAGAGTAATTTGAGTGGAGGAGAAAACCGAGTGCAAGTCCTAAAGACTGTTCCAGTGAACCTTTCCCTAAATCAA GATCACCTGGAGAATTCCAAGCGGGAACAGTACAGCATCAGCTTCCCCGAGAGCTCTGCCATCATCCCGGTGTCGGGAATCACGGTGGTG AAAGCTGAAGATTTCACACCAGTTTTCATGGCCCCACCTGTGCACTATCCCCGGGGAGATGGGGAAGAGCAACGAGTGGTTATCTTTGAA CAGACTCAGTATGACGTGCCCTCGCTGGCCACCCACAGCGCCTATCTCAAAGACGACCAGCGCAGCACTCCGGACAGCACATACAGCGAG AGCTTCAAGGACGCAGCCACAGAGAAATTTCGGAGTGCTTCAGTTGGGGCTGAGGAGTACATGTATGATCAGACATCAAGTGGCACATTT CAGTACACCCTGGAAGCCACCAAATCTCTCCGTCAGAAGCAGGGGGAGGGCCCCATGACCTACCTCAACAAAGGACAGTTCTATGCCATA ACACTCAGCGAGACCGGAGACAACAAATGCTTCCGACACCCCATCAGCAAAGTCAGGAGTGTGGTGATGGTGGTCTTCAGTGAAGACAAA AACAGAGATGAACAGCTCAAATACTGGAAATACTGGCACTCTCGGCAGCATACGGCGAAGCAGAGGGTCCTTGACATTGCCGATTACAAG GAGAGCTTTAATACGATTGGAAACATTGAAGAGATTGCATATAATGCTGTTTCCTTTACCTGGGACGTGAATGAAGAGGCGAAGATTTTC ATCACCGTGAATTGCTTGAGCACAGATTTCTCCTCCCAAAAAGGGGTGAAAGGACTTCCTTTGATGATTCAGATTGACACATACAGTTAT AACAATCGTAGCAATAAACCCATTCATAGAGCTTATTGCCAGATCAAGGTCTTCTGTGACAAAGGAGCAGAAAGAAAAATCCGAGATGAA GAGCGGAAGCAGAACAGGAAGAAAGGGAAAGGCCAGGCCTCCCAAACTCAATGCAACAGCTCCTCTGATGGGAAGTTGGCTGCCATACCT TTACAGAAGAAGAGTGACATCACCTACTTCAAAACCATGCCTGATCTCCACTCACAGCCAGTTCTCTTCATACCTGATGTTCACTTTGCA AACCTGCAGAGGACCGGACAGGTGTATTACAACACGGATGATGAACGAGAAGGTGGCAGTGTCCTTGTTAAACGGATGTTCCGGCCCATG GAAGAGGAGTTTGGTCCAGTGCCTTCAAAGCAGATGAAAGAAGAAGGGACAAAGCGAGTGCTCTTGTACGTGAGGAAGGAGACTGACGAT GTGTTCGATGCATTGATGTTGAAGTCTCCCACAGTGAAGGGCCTGATGGAAGCGATATCTGAGAAATATGGGCTGCCCGTGGAGAAGATA GCAAAGCTTTACAAGAAAAGCAAAAAAGGCATCTTGGTGAACATGGATGACAACATCATCGAGCACTACTCGAACGAGGACACCTTCATC CTCAACATGGAGAGCATGGTGGAGGGCTTCAAGGTCACGCTCATGGAAATCTAGCCCTGGGTTTGGCATCCGCTTTGGCTGGAGCTCTCA GTGCGTTCCTCCCTGAGAGAGACAGAAGCCCCAGCCCCAGAACCTGGAGACCCATCTCCCCCATCTCACAACTGCTGTTACAAGACCGTG CTGGGGAGTGGGGCAAGGGACAGGCCCCACTGTCGGTGTGCTTGGCCCATCCACTGGCACCTACCACGGAGCTGAAGCCTGAGCCCCTCA GGAAGGTGCCTTAGGCCTGTTGGATTCCTATTTATTGCCCACCTTTTCCTGGAGCCCAGGTCCAGGCCCGCCAGGACTCTGCAGGTCACT GCTAGCTCCAGATGAGACCGTCCAGCGTTCCCCCTTCAAGAGAAACACTCATCCCGAACAGCCTAAAAAATTCCCATCCCTTCTCTCTCA CCCCTCCATATCTATCTCCCGAGTGGCTGGACAAAATGAGCTACGTCTGGGTGCAGTAGTTATAGGTGGGGCAAGAGGTGGATGCCCACT TTCTGGTCAGACACCTTTAGGTTGCTCTGGGGAAGGCTGTCTTGCTAAATACCTCCAGGGTTCCCAGCAAGTGGCCACCAGGCCTTGTAC AGGAAGACATTCAGTCACCGTGTAATTAGTAACACAGAAAGTCTGCCTGTCTGCATTGTACATAGTGTTTATAATATTGTAATAATATAT TTTACCTGTGGTATGTGGGCATGTTTACTGCCACTGGCCTAGAGGAGACACAGACCTGGAGACCGTTTTAATGGGGGTTTTTGCCTCTGT GCCTGTTCAAGAGACTTGCAGGGCTAGGTAGAGGGCCTTTGGGATGTTAAGGTGACTGCAGCTGATGCCAAGATGGACTCTGCAATGGGC ATACCTGGGGGCTCGTTCCCTGTCCCCAGAGGAAGCCCCCTCTCCTTCTCCATGGGCATGACTCTCCTTCGAGGCCACCACGTTTATCTC ACAATGATGTGTTTTGCTTGACTTTCCCTTTGCGCTGTCTCGTGGGAAAGGTCATTCTGTCTGAGACCCCAGCTCCTTCTCCAGCTTTGG CTGCGGGCATGGCCTGAGCTTTCTGGAGAGCCTCTGCAGGGGGTTTGCCATCAGGGCCCTGTGGCTGGGTCTGCTGCAGAGCTCCTTGGC TATCAGGAGAATCCTGGACACTGTACTGTGCCTCCCAGTTTACAAACACGCCCTTCATCTCAAGTGGCCCTTTAAAAGGCCTGCTGCCAT GTGAGAGCTGTGAACAGCTCAGCTCTGAGTCGGCAGGCTGGGGCTTCCTCCTGGGCCACCAGATGGAAAGGGGGTATTGTTTGCCTCACT CCTGGATGCTGCGTTTTAAGGAAGTGAGTGAGAAAGAATGTGCCAAGATACCTGGCTCCTGTGAAACCAGCCTCAGGAGGGAAACTGGGA GAGAGAAGCTGTGGTCTCCTGCTACATGCCCTGGGAGCTGGAAGAGAAAAACACTCCCCTAAACAATCGCAAAATGATGAACCATCATGG GCCACTGTTCTCTTTGAGGGGACAGGTTTAGGGGTTTGCGTTCGCCCTTGTGGGCTGAAGCACTAGCTTTTTGGTAGCTAGACACATCCT GCACCCAAAGGTTCTCTACAAAGGCCCAGATTTGTTTGTAAAGCACTTTGACTCTTACCTGGAGGCCCGCTCTCTAAGGGCTTCCTGCGC TCCCACCTCATCTGTCCCTGAGATGCAGAGCAGGATGGAGGGTCTGCTTCTAGCTCAGCTGTTTCTCCTTGAGGTTGCGGAGGAATTGAA TTGAATGGGACAGAGGGCAGGTGCTGTGGCCAAGAAGATCTCCGAGCAGCAGTGACGGGGCACCTTGCTGTGTGTCCTCTGGGCATGTTA ACCCTTCTGTGGGGCCAAAGGTTTGCATCGTGGATCCAGCTGTGCTCCAGTCTGTCCCCTCCTCCTCCACTCTGACTGCCACGCCCCGGA CCAGCAGCTTGGGGACCCTCCAGGGTACTAATGGGGCTCTGTTCTGAGATGGACAAATTCAGTGTTGGAAATACATGTTGTACTATGCAC TTCCCATGCTCCTAGGGTTAGGAATAGTTTCAAACATGATTGGCAGACATAACAACGGCAAATACTCGGACTGGGGCATAGGACTCCAGA GTAGGAAAAAGACAAAAGATTTGGCAGCCTGACACAGGCAACCTACCCCTCTCTCTCCAGCCTCTTTATGAAACTGTTTGTTTGCCAGTC CTGCCCTAAGGCAGAAGATGAATTGAAGATGCTGTGCATGTTTCCTAAGTCCTTGAGCAATCATGGTGGTGACAATTGCCACAAGGGATA TGAGGCCAGTGCCACCAGAGGGTGGTGCCAAGTGCCACATCCCTTCCGATCCATTCCCCTCTGCATCCTCGGAGCACCCCAGTTTGCCTT TGATGTGTCCGCTGTGTATGTTAGCTGAACTTTGATGAGCAAAATTTCCTGAGCGAAACACTCCAAAGAGATAGGAAAACTTGCCGCCTC TTCTTTTTTGTCCCTTAATCAAACTCAAATAAGCTTAAAAAAAATCCATGGAAGATCATGGACATGTGAAATGAGCATTTTTTTCTTTTT TTTTTTTAACAAAGTCTGAACTGAACAGAACAAGACTTTTTCCTCATACATCTCCAAATTGTTTAAACTTACTTTATGAGTGTTTGTTTA GAAGTTCGGACCAACAGAAAAATGCAGTCAGATGTCATCTTGGAATTGGTTTCTAAAAGAGTAAGGCATGTCCCTGCCCAGAAACTTAGG AAGCATGAAATAAATCAAATGTTTATTTTCCTTCTTATTTAAAATCATGCAAATGCAACAGAAATAGAGGGTTTGTGCCAAATGCTATGA ACGGCCCTTTCTTAAAGACAAGCAAGGGAGATTGATATATGTACAATTTGCTCTCATGTTTTAAAAAAAAAAAGGTAAATGTAACTTAAT AGTTTTGTAAATGGGAGAGGGGGAATCTATAAACTATAAATACAGTTATTTTATTTTTTGTACATTTTTAAGGAGAAAAAATAAATATTC >10859_10859_2_C12orf52-GRHL2_C12orf52_chr12_113624853_ENST00000549621_GRHL2_chr8_102555469_ENST00000251808_length(amino acids)=734AA_BP=114 MAGRAHLLSPGTTGSMKTPVELAVSGMQTLGLQHRCRGGYRVKARTSYVDETLFGSPAGTRPTPPDFDPPWVEKANRTRGVGKEASKALG AKGSCETTPSRGSTPTLTPRKKNKYSNKRLVALVPMPSDPPFNTRRAYTSEDEAWKSYLENPLTAATKAMMSINGDEDSAAALGLLYDYY KVPRDKRLLSVSKASDSQEDQEKRNCLGTSEAQSNLSGGENRVQVLKTVPVNLSLNQDHLENSKREQYSISFPESSAIIPVSGITVVKAE DFTPVFMAPPVHYPRGDGEEQRVVIFEQTQYDVPSLATHSAYLKDDQRSTPDSTYSESFKDAATEKFRSASVGAEEYMYDQTSSGTFQYT LEATKSLRQKQGEGPMTYLNKGQFYAITLSETGDNKCFRHPISKVRSVVMVVFSEDKNRDEQLKYWKYWHSRQHTAKQRVLDIADYKESF NTIGNIEEIAYNAVSFTWDVNEEAKIFITVNCLSTDFSSQKGVKGLPLMIQIDTYSYNNRSNKPIHRAYCQIKVFCDKGAERKIRDEERK QNRKKGKGQASQTQCNSSSDGKLAAIPLQKKSDITYFKTMPDLHSQPVLFIPDVHFANLQRTGQVYYNTDDEREGGSVLVKRMFRPMEEE FGPVPSKQMKEEGTKRVLLYVRKETDDVFDALMLKSPTVKGLMEAISEKYGLPVEKIAKLYKKSKKGILVNMDDNIIEHYSNEDTFILNM -------------------------------------------------------------- >10859_10859_3_C12orf52-GRHL2_C12orf52_chr12_113624853_ENST00000552495_GRHL2_chr8_102555469_ENST00000251808_length(transcript)=5727nt_BP=846nt CTCCGCTGAGCTTTCGCCAGTGCCTGCGGCCCTCGGCGGCCTAGTACACACGCACCTGAGTGAGTGGCACCAGAGGACCCTCTCCATGTT TAGGGACCTCCTGGGCCTCAGGAGCGTGGCGCCCGCCCCTGGGCGGACTCCCCCCATCCGCGGGCGCGAATGGTCCGGGCCGCGTCCGCA GTGCTGCTGGCTGCTCCCTGGTTGCTGGGTGCAAAGTGCTGGGTTCTGGGTTTCTGGATTCGCGGGCCGTTCACACGTAGCCTGTGCCGG CTCCTCGGGTGAGTCCGTCCGCGCGCGGTGCCCCGGGACGGCCTAGGCTGCCGGGGGTCCGGGGCCCCAGGCATTCCGGGCTGCAGATTG ACGGGGATCCCGGATGCACCGCGCGCCCCCGCGCCCTCACCGACGGGTCCAGACCTGGTGGGAAGAAGGTGCGGGGACGGGTCCCTGAGG ATCCCGATGCCTACGAGCCAAGATGCTCAGGGAGCCTCGGAAGCAGGGCCTGGCCGGCAGAGCACACCTGCTGTCACCAGGGACCACAGG CAGCATGAAGACCCCCGTGGAGCTGGCCGTCAGTGGGATGCAGACCCTCGGCCTTCAGCACCGCTGCCGAGGTGGCTACCGGGTCAAGGC CAGGACGTCATATGTGGATGAGACTCTGTTTGGCAGCCCAGCAGGCACCCGGCCTACCCCACCGGACTTCGATCCGCCCTGGGTGGAGAA GGCTAACAGAACCAGAGGCGTGGGCAAGGAGGCATCGAAGGCCTTGGGGGCAAAGGGGAGCTGTGAGACCACCCCCTCAAGGGGCAGCAC CCCCACCCTCACACCAAGGAAGAAGAACAAATACAGTAATAAAAGACTAGTGGCCTTAGTGCCCATGCCCAGTGACCCTCCATTCAATAC CCGAAGAGCCTACACCAGTGAGGATGAAGCCTGGAAGTCATACTTGGAGAATCCCCTGACAGCAGCCACCAAGGCCATGATGAGCATTAA TGGTGATGAGGACAGTGCTGCTGCCCTCGGCCTGCTCTATGACTACTACAAGGTTCCTCGAGACAAGAGGCTGCTGTCTGTAAGCAAAGC AAGTGACAGCCAAGAAGACCAGGAGAAAAGAAACTGCCTTGGCACCAGTGAAGCCCAGAGTAATTTGAGTGGAGGAGAAAACCGAGTGCA AGTCCTAAAGACTGTTCCAGTGAACCTTTCCCTAAATCAAGATCACCTGGAGAATTCCAAGCGGGAACAGTACAGCATCAGCTTCCCCGA GAGCTCTGCCATCATCCCGGTGTCGGGAATCACGGTGGTGAAAGCTGAAGATTTCACACCAGTTTTCATGGCCCCACCTGTGCACTATCC CCGGGGAGATGGGGAAGAGCAACGAGTGGTTATCTTTGAACAGACTCAGTATGACGTGCCCTCGCTGGCCACCCACAGCGCCTATCTCAA AGACGACCAGCGCAGCACTCCGGACAGCACATACAGCGAGAGCTTCAAGGACGCAGCCACAGAGAAATTTCGGAGTGCTTCAGTTGGGGC TGAGGAGTACATGTATGATCAGACATCAAGTGGCACATTTCAGTACACCCTGGAAGCCACCAAATCTCTCCGTCAGAAGCAGGGGGAGGG CCCCATGACCTACCTCAACAAAGGACAGTTCTATGCCATAACACTCAGCGAGACCGGAGACAACAAATGCTTCCGACACCCCATCAGCAA AGTCAGGAGTGTGGTGATGGTGGTCTTCAGTGAAGACAAAAACAGAGATGAACAGCTCAAATACTGGAAATACTGGCACTCTCGGCAGCA TACGGCGAAGCAGAGGGTCCTTGACATTGCCGATTACAAGGAGAGCTTTAATACGATTGGAAACATTGAAGAGATTGCATATAATGCTGT TTCCTTTACCTGGGACGTGAATGAAGAGGCGAAGATTTTCATCACCGTGAATTGCTTGAGCACAGATTTCTCCTCCCAAAAAGGGGTGAA AGGACTTCCTTTGATGATTCAGATTGACACATACAGTTATAACAATCGTAGCAATAAACCCATTCATAGAGCTTATTGCCAGATCAAGGT CTTCTGTGACAAAGGAGCAGAAAGAAAAATCCGAGATGAAGAGCGGAAGCAGAACAGGAAGAAAGGGAAAGGCCAGGCCTCCCAAACTCA ATGCAACAGCTCCTCTGATGGGAAGTTGGCTGCCATACCTTTACAGAAGAAGAGTGACATCACCTACTTCAAAACCATGCCTGATCTCCA CTCACAGCCAGTTCTCTTCATACCTGATGTTCACTTTGCAAACCTGCAGAGGACCGGACAGGTGTATTACAACACGGATGATGAACGAGA AGGTGGCAGTGTCCTTGTTAAACGGATGTTCCGGCCCATGGAAGAGGAGTTTGGTCCAGTGCCTTCAAAGCAGATGAAAGAAGAAGGGAC AAAGCGAGTGCTCTTGTACGTGAGGAAGGAGACTGACGATGTGTTCGATGCATTGATGTTGAAGTCTCCCACAGTGAAGGGCCTGATGGA AGCGATATCTGAGAAATATGGGCTGCCCGTGGAGAAGATAGCAAAGCTTTACAAGAAAAGCAAAAAAGGCATCTTGGTGAACATGGATGA CAACATCATCGAGCACTACTCGAACGAGGACACCTTCATCCTCAACATGGAGAGCATGGTGGAGGGCTTCAAGGTCACGCTCATGGAAAT CTAGCCCTGGGTTTGGCATCCGCTTTGGCTGGAGCTCTCAGTGCGTTCCTCCCTGAGAGAGACAGAAGCCCCAGCCCCAGAACCTGGAGA CCCATCTCCCCCATCTCACAACTGCTGTTACAAGACCGTGCTGGGGAGTGGGGCAAGGGACAGGCCCCACTGTCGGTGTGCTTGGCCCAT CCACTGGCACCTACCACGGAGCTGAAGCCTGAGCCCCTCAGGAAGGTGCCTTAGGCCTGTTGGATTCCTATTTATTGCCCACCTTTTCCT GGAGCCCAGGTCCAGGCCCGCCAGGACTCTGCAGGTCACTGCTAGCTCCAGATGAGACCGTCCAGCGTTCCCCCTTCAAGAGAAACACTC ATCCCGAACAGCCTAAAAAATTCCCATCCCTTCTCTCTCACCCCTCCATATCTATCTCCCGAGTGGCTGGACAAAATGAGCTACGTCTGG GTGCAGTAGTTATAGGTGGGGCAAGAGGTGGATGCCCACTTTCTGGTCAGACACCTTTAGGTTGCTCTGGGGAAGGCTGTCTTGCTAAAT ACCTCCAGGGTTCCCAGCAAGTGGCCACCAGGCCTTGTACAGGAAGACATTCAGTCACCGTGTAATTAGTAACACAGAAAGTCTGCCTGT CTGCATTGTACATAGTGTTTATAATATTGTAATAATATATTTTACCTGTGGTATGTGGGCATGTTTACTGCCACTGGCCTAGAGGAGACA CAGACCTGGAGACCGTTTTAATGGGGGTTTTTGCCTCTGTGCCTGTTCAAGAGACTTGCAGGGCTAGGTAGAGGGCCTTTGGGATGTTAA GGTGACTGCAGCTGATGCCAAGATGGACTCTGCAATGGGCATACCTGGGGGCTCGTTCCCTGTCCCCAGAGGAAGCCCCCTCTCCTTCTC CATGGGCATGACTCTCCTTCGAGGCCACCACGTTTATCTCACAATGATGTGTTTTGCTTGACTTTCCCTTTGCGCTGTCTCGTGGGAAAG GTCATTCTGTCTGAGACCCCAGCTCCTTCTCCAGCTTTGGCTGCGGGCATGGCCTGAGCTTTCTGGAGAGCCTCTGCAGGGGGTTTGCCA TCAGGGCCCTGTGGCTGGGTCTGCTGCAGAGCTCCTTGGCTATCAGGAGAATCCTGGACACTGTACTGTGCCTCCCAGTTTACAAACACG CCCTTCATCTCAAGTGGCCCTTTAAAAGGCCTGCTGCCATGTGAGAGCTGTGAACAGCTCAGCTCTGAGTCGGCAGGCTGGGGCTTCCTC CTGGGCCACCAGATGGAAAGGGGGTATTGTTTGCCTCACTCCTGGATGCTGCGTTTTAAGGAAGTGAGTGAGAAAGAATGTGCCAAGATA CCTGGCTCCTGTGAAACCAGCCTCAGGAGGGAAACTGGGAGAGAGAAGCTGTGGTCTCCTGCTACATGCCCTGGGAGCTGGAAGAGAAAA ACACTCCCCTAAACAATCGCAAAATGATGAACCATCATGGGCCACTGTTCTCTTTGAGGGGACAGGTTTAGGGGTTTGCGTTCGCCCTTG TGGGCTGAAGCACTAGCTTTTTGGTAGCTAGACACATCCTGCACCCAAAGGTTCTCTACAAAGGCCCAGATTTGTTTGTAAAGCACTTTG ACTCTTACCTGGAGGCCCGCTCTCTAAGGGCTTCCTGCGCTCCCACCTCATCTGTCCCTGAGATGCAGAGCAGGATGGAGGGTCTGCTTC TAGCTCAGCTGTTTCTCCTTGAGGTTGCGGAGGAATTGAATTGAATGGGACAGAGGGCAGGTGCTGTGGCCAAGAAGATCTCCGAGCAGC AGTGACGGGGCACCTTGCTGTGTGTCCTCTGGGCATGTTAACCCTTCTGTGGGGCCAAAGGTTTGCATCGTGGATCCAGCTGTGCTCCAG TCTGTCCCCTCCTCCTCCACTCTGACTGCCACGCCCCGGACCAGCAGCTTGGGGACCCTCCAGGGTACTAATGGGGCTCTGTTCTGAGAT GGACAAATTCAGTGTTGGAAATACATGTTGTACTATGCACTTCCCATGCTCCTAGGGTTAGGAATAGTTTCAAACATGATTGGCAGACAT AACAACGGCAAATACTCGGACTGGGGCATAGGACTCCAGAGTAGGAAAAAGACAAAAGATTTGGCAGCCTGACACAGGCAACCTACCCCT CTCTCTCCAGCCTCTTTATGAAACTGTTTGTTTGCCAGTCCTGCCCTAAGGCAGAAGATGAATTGAAGATGCTGTGCATGTTTCCTAAGT CCTTGAGCAATCATGGTGGTGACAATTGCCACAAGGGATATGAGGCCAGTGCCACCAGAGGGTGGTGCCAAGTGCCACATCCCTTCCGAT CCATTCCCCTCTGCATCCTCGGAGCACCCCAGTTTGCCTTTGATGTGTCCGCTGTGTATGTTAGCTGAACTTTGATGAGCAAAATTTCCT GAGCGAAACACTCCAAAGAGATAGGAAAACTTGCCGCCTCTTCTTTTTTGTCCCTTAATCAAACTCAAATAAGCTTAAAAAAAATCCATG GAAGATCATGGACATGTGAAATGAGCATTTTTTTCTTTTTTTTTTTTAACAAAGTCTGAACTGAACAGAACAAGACTTTTTCCTCATACA TCTCCAAATTGTTTAAACTTACTTTATGAGTGTTTGTTTAGAAGTTCGGACCAACAGAAAAATGCAGTCAGATGTCATCTTGGAATTGGT TTCTAAAAGAGTAAGGCATGTCCCTGCCCAGAAACTTAGGAAGCATGAAATAAATCAAATGTTTATTTTCCTTCTTATTTAAAATCATGC AAATGCAACAGAAATAGAGGGTTTGTGCCAAATGCTATGAACGGCCCTTTCTTAAAGACAAGCAAGGGAGATTGATATATGTACAATTTG CTCTCATGTTTTAAAAAAAAAAAGGTAAATGTAACTTAATAGTTTTGTAAATGGGAGAGGGGGAATCTATAAACTATAAATACAGTTATT >10859_10859_3_C12orf52-GRHL2_C12orf52_chr12_113624853_ENST00000552495_GRHL2_chr8_102555469_ENST00000251808_length(amino acids)=743AA_BP=123 MLREPRKQGLAGRAHLLSPGTTGSMKTPVELAVSGMQTLGLQHRCRGGYRVKARTSYVDETLFGSPAGTRPTPPDFDPPWVEKANRTRGV GKEASKALGAKGSCETTPSRGSTPTLTPRKKNKYSNKRLVALVPMPSDPPFNTRRAYTSEDEAWKSYLENPLTAATKAMMSINGDEDSAA ALGLLYDYYKVPRDKRLLSVSKASDSQEDQEKRNCLGTSEAQSNLSGGENRVQVLKTVPVNLSLNQDHLENSKREQYSISFPESSAIIPV SGITVVKAEDFTPVFMAPPVHYPRGDGEEQRVVIFEQTQYDVPSLATHSAYLKDDQRSTPDSTYSESFKDAATEKFRSASVGAEEYMYDQ TSSGTFQYTLEATKSLRQKQGEGPMTYLNKGQFYAITLSETGDNKCFRHPISKVRSVVMVVFSEDKNRDEQLKYWKYWHSRQHTAKQRVL DIADYKESFNTIGNIEEIAYNAVSFTWDVNEEAKIFITVNCLSTDFSSQKGVKGLPLMIQIDTYSYNNRSNKPIHRAYCQIKVFCDKGAE RKIRDEERKQNRKKGKGQASQTQCNSSSDGKLAAIPLQKKSDITYFKTMPDLHSQPVLFIPDVHFANLQRTGQVYYNTDDEREGGSVLVK RMFRPMEEEFGPVPSKQMKEEGTKRVLLYVRKETDDVFDALMLKSPTVKGLMEAISEKYGLPVEKIAKLYKKSKKGILVNMDDNIIEHYS -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for RITA1-GRHL2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for RITA1-GRHL2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for RITA1-GRHL2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | C3711374 | Nonsyndromic Deafness | 4 | CLINGEN | |
| Tgene | C0339284 | Polymorphous corneal dystrophy | 1 | ORPHANET | |
| Tgene | C1384666 | hearing impairment | 1 | GENOMICS_ENGLAND | |
| Tgene | C1837640 | Deafness, Autosomal Dominant 28 | 1 | CTD_human;GENOMICS_ENGLAND | |
| Tgene | C4014987 | Nail and tooth abnormalities, marginal palmoplantar keratoderma, oral hyperpigmentation syndrome | 1 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
| Tgene | C4747961 | CORNEAL DYSTROPHY, POSTERIOR POLYMORPHOUS, 4 | 1 | GENOMICS_ENGLAND |
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