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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FBXL20-ABCA6 (FusionGDB2 ID:HG84961TG23460)

Fusion Gene Summary for FBXL20-ABCA6

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXL20-ABCA6
Fusion gene ID: hg84961tg23460
HgeneTgene
Gene symbol

FBXL20

ABCA6

Gene ID

84961

23460

Gene nameF-box and leucine rich repeat protein 20ATP binding cassette subfamily A member 6
SynonymsFbl2|Fbl20EST155051
Cytomap('FBXL20')('ABCA6')

17q12

17q24.2-q24.3

Type of geneprotein-codingprotein-coding
DescriptionF-box/LRR-repeat protein 20F-box protein FBL2ATP-binding cassette sub-family A member 6ABC transporter ABCA6ATP-binding cassette A6ATP-binding cassette, sub-family A (ABC1), member 6
Modification date2020031320200313
UniProtAcc.

Q8N139

Ensembl transtripts involved in fusion geneENST00000264658, ENST00000394294, 
ENST00000583610, ENST00000577399, 
Fusion gene scores* DoF score58 X 21 X 16=194884 X 4 X 3=48
# samples 614
** MAII scorelog2(61/19488*10)=-4.99763298545608
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FBXL20 [Title/Abstract] AND ABCA6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFBXL20(37557614)-ABCA6(67124945), # samples:1
Anticipated loss of major functional domain due to fusion event.FBXL20-ABCA6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FBXL20-ABCA6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FBXL20-ABCA6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FBXL20-ABCA6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FBXL20 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ABCA6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A0T1-01AFBXL20chr17

37557614

-ABCA6chr17

67124945

-


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Fusion Gene ORF analysis for FBXL20-ABCA6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000264658ENST00000446604FBXL20chr17

37557614

-ABCA6chr17

67124945

-
5CDS-intronENST00000264658ENST00000590645FBXL20chr17

37557614

-ABCA6chr17

67124945

-
5CDS-intronENST00000394294ENST00000446604FBXL20chr17

37557614

-ABCA6chr17

67124945

-
5CDS-intronENST00000394294ENST00000590645FBXL20chr17

37557614

-ABCA6chr17

67124945

-
5CDS-intronENST00000583610ENST00000446604FBXL20chr17

37557614

-ABCA6chr17

67124945

-
5CDS-intronENST00000583610ENST00000590645FBXL20chr17

37557614

-ABCA6chr17

67124945

-
In-frameENST00000264658ENST00000284425FBXL20chr17

37557614

-ABCA6chr17

67124945

-
In-frameENST00000394294ENST00000284425FBXL20chr17

37557614

-ABCA6chr17

67124945

-
In-frameENST00000583610ENST00000284425FBXL20chr17

37557614

-ABCA6chr17

67124945

-
intron-3CDSENST00000577399ENST00000284425FBXL20chr17

37557614

-ABCA6chr17

67124945

-
intron-intronENST00000577399ENST00000446604FBXL20chr17

37557614

-ABCA6chr17

67124945

-
intron-intronENST00000577399ENST00000590645FBXL20chr17

37557614

-ABCA6chr17

67124945

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000583610FBXL20chr1737557614-ENST00000284425ABCA6chr1767124945-448829625442161320
ENST00000394294FBXL20chr1737557614-ENST00000284425ABCA6chr1767124945-445526322141831320
ENST00000264658FBXL20chr1737557614-ENST00000284425ABCA6chr1767124945-449530326142231320

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000583610ENST00000284425FBXL20chr1737557614-ABCA6chr1767124945-9.61E-050.9999039
ENST00000394294ENST00000284425FBXL20chr1737557614-ABCA6chr1767124945-9.31E-050.9999069
ENST00000264658ENST00000284425FBXL20chr1737557614-ABCA6chr1767124945-9.51E-050.9999049

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Fusion Genomic Features for FBXL20-ABCA6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for FBXL20-ABCA6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:37557614/chr17:67124945)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ABCA6

Q8N139

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Probable transporter which may play a role in macrophage lipid transport and homeostasis. {ECO:0000305|PubMed:10639163}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneABCA6chr17:37557614chr17:67124945ENST000002844256391288_15133111618.0DomainABC transporter 2
TgeneABCA6chr17:37557614chr17:67124945ENST00000284425639478_7133111618.0DomainABC transporter 1
TgeneABCA6chr17:37557614chr17:67124945ENST00000590645041288_15130186.0DomainABC transporter 2
TgeneABCA6chr17:37557614chr17:67124945ENST0000059064504478_7130186.0DomainABC transporter 1
TgeneABCA6chr17:37557614chr17:67124945ENST000002844256391320_13273111618.0Nucleotide bindingATP 2
TgeneABCA6chr17:37557614chr17:67124945ENST00000284425639514_5213111618.0Nucleotide bindingATP 1
TgeneABCA6chr17:37557614chr17:67124945ENST00000590645041320_13270186.0Nucleotide bindingATP 2
TgeneABCA6chr17:37557614chr17:67124945ENST0000059064504514_5210186.0Nucleotide bindingATP 1
TgeneABCA6chr17:37557614chr17:67124945ENST000002844256391007_10273111618.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST000002844256391062_10823111618.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST000002844256391094_11143111618.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST000002844256391127_11473111618.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST000002844256391150_11703111618.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST000002844256391194_12143111618.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST00000284425639327_3473111618.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST00000284425639355_3753111618.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST00000284425639397_4173111618.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST00000284425639854_8743111618.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST00000590645041007_10270186.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST00000590645041062_10820186.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST00000590645041094_11140186.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST00000590645041127_11470186.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST00000590645041150_11700186.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST00000590645041194_12140186.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST0000059064504222_2420186.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST0000059064504268_2880186.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST0000059064504297_3170186.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST000005906450431_510186.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST0000059064504327_3470186.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST0000059064504355_3750186.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST0000059064504397_4170186.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST0000059064504854_8740186.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFBXL20chr17:37557614chr17:67124945ENST00000264658-11522_6814437.0DomainF-box
HgeneFBXL20chr17:37557614chr17:67124945ENST00000394294-11422_6814405.0DomainF-box
HgeneFBXL20chr17:37557614chr17:67124945ENST00000583610-11622_6814411.6666666666667DomainF-box
HgeneFBXL20chr17:37557614chr17:67124945ENST00000264658-115101_12614437.0RepeatNote=LRR 2
HgeneFBXL20chr17:37557614chr17:67124945ENST00000264658-115127_15214437.0RepeatNote=LRR 3
HgeneFBXL20chr17:37557614chr17:67124945ENST00000264658-115153_17814437.0RepeatNote=LRR 4
HgeneFBXL20chr17:37557614chr17:67124945ENST00000264658-115179_20414437.0RepeatNote=LRR 5
HgeneFBXL20chr17:37557614chr17:67124945ENST00000264658-115205_23014437.0RepeatNote=LRR 6
HgeneFBXL20chr17:37557614chr17:67124945ENST00000264658-115231_25614437.0RepeatNote=LRR 7
HgeneFBXL20chr17:37557614chr17:67124945ENST00000264658-115257_28214437.0RepeatNote=LRR 8
HgeneFBXL20chr17:37557614chr17:67124945ENST00000264658-115283_30814437.0RepeatNote=LRR 9
HgeneFBXL20chr17:37557614chr17:67124945ENST00000264658-115309_33414437.0RepeatNote=LRR 10
HgeneFBXL20chr17:37557614chr17:67124945ENST00000264658-115335_36314437.0RepeatNote=LRR 11
HgeneFBXL20chr17:37557614chr17:67124945ENST00000264658-115364_38814437.0RepeatNote=LRR 12
HgeneFBXL20chr17:37557614chr17:67124945ENST00000264658-115389_41414437.0RepeatNote=LRR 13
HgeneFBXL20chr17:37557614chr17:67124945ENST00000264658-11574_10014437.0RepeatNote=LRR 1
HgeneFBXL20chr17:37557614chr17:67124945ENST00000394294-114101_12614405.0RepeatNote=LRR 2
HgeneFBXL20chr17:37557614chr17:67124945ENST00000394294-114127_15214405.0RepeatNote=LRR 3
HgeneFBXL20chr17:37557614chr17:67124945ENST00000394294-114153_17814405.0RepeatNote=LRR 4
HgeneFBXL20chr17:37557614chr17:67124945ENST00000394294-114179_20414405.0RepeatNote=LRR 5
HgeneFBXL20chr17:37557614chr17:67124945ENST00000394294-114205_23014405.0RepeatNote=LRR 6
HgeneFBXL20chr17:37557614chr17:67124945ENST00000394294-114231_25614405.0RepeatNote=LRR 7
HgeneFBXL20chr17:37557614chr17:67124945ENST00000394294-114257_28214405.0RepeatNote=LRR 8
HgeneFBXL20chr17:37557614chr17:67124945ENST00000394294-114283_30814405.0RepeatNote=LRR 9
HgeneFBXL20chr17:37557614chr17:67124945ENST00000394294-114309_33414405.0RepeatNote=LRR 10
HgeneFBXL20chr17:37557614chr17:67124945ENST00000394294-114335_36314405.0RepeatNote=LRR 11
HgeneFBXL20chr17:37557614chr17:67124945ENST00000394294-114364_38814405.0RepeatNote=LRR 12
HgeneFBXL20chr17:37557614chr17:67124945ENST00000394294-114389_41414405.0RepeatNote=LRR 13
HgeneFBXL20chr17:37557614chr17:67124945ENST00000394294-11474_10014405.0RepeatNote=LRR 1
HgeneFBXL20chr17:37557614chr17:67124945ENST00000583610-116101_12614411.6666666666667RepeatNote=LRR 2
HgeneFBXL20chr17:37557614chr17:67124945ENST00000583610-116127_15214411.6666666666667RepeatNote=LRR 3
HgeneFBXL20chr17:37557614chr17:67124945ENST00000583610-116153_17814411.6666666666667RepeatNote=LRR 4
HgeneFBXL20chr17:37557614chr17:67124945ENST00000583610-116179_20414411.6666666666667RepeatNote=LRR 5
HgeneFBXL20chr17:37557614chr17:67124945ENST00000583610-116205_23014411.6666666666667RepeatNote=LRR 6
HgeneFBXL20chr17:37557614chr17:67124945ENST00000583610-116231_25614411.6666666666667RepeatNote=LRR 7
HgeneFBXL20chr17:37557614chr17:67124945ENST00000583610-116257_28214411.6666666666667RepeatNote=LRR 8
HgeneFBXL20chr17:37557614chr17:67124945ENST00000583610-116283_30814411.6666666666667RepeatNote=LRR 9
HgeneFBXL20chr17:37557614chr17:67124945ENST00000583610-116309_33414411.6666666666667RepeatNote=LRR 10
HgeneFBXL20chr17:37557614chr17:67124945ENST00000583610-116335_36314411.6666666666667RepeatNote=LRR 11
HgeneFBXL20chr17:37557614chr17:67124945ENST00000583610-116364_38814411.6666666666667RepeatNote=LRR 12
HgeneFBXL20chr17:37557614chr17:67124945ENST00000583610-116389_41414411.6666666666667RepeatNote=LRR 13
HgeneFBXL20chr17:37557614chr17:67124945ENST00000583610-11674_10014411.6666666666667RepeatNote=LRR 1
TgeneABCA6chr17:37557614chr17:67124945ENST00000284425639222_2423111618.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST00000284425639268_2883111618.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST00000284425639297_3173111618.0TransmembraneHelical
TgeneABCA6chr17:37557614chr17:67124945ENST0000028442563931_513111618.0TransmembraneHelical


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Fusion Gene Sequence for FBXL20-ABCA6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>29626_29626_1_FBXL20-ABCA6_FBXL20_chr17_37557614_ENST00000264658_ABCA6_chr17_67124945_ENST00000284425_length(transcript)=4495nt_BP=303nt
GGGGAGTGTTTTTGTTTTGGGTTGAAGTTGAGGCTGAGGAGAGAGCCGAGCTAGCGACGAGCAGTCGTTGCGGCCGCCGGCGCCGCGGGA
GGTGGTGGAGGCCTAGCCGGAGCCGAGAGGTCTCTTGTTCCCGTCCCACGGTCCCGGCGTCACCCCTCCGGCGCCCAGTCCCCGTCCCGG
AACTCCCGGGCCTGTCCTGGGCCCCCGGTCTGTGCACTCCGCTCGCCGCAGCGCCCGGCCCGGGCCGCACCCGCCGGCCCCATGAGGAGG
GACGTGAACGGAGTGACCAAGAGCAGGTTTGAGGTAGCTTTGGTGTTCCTGATGAGTGTGCTGTTAAAGAAAGCTGTCCTCACCAATTTG
GTTGTGTTTCTCCTTACCCTCTTTTGGGGATGTCTGGGATTCACTGTATTTTATGAACAACTTCCTTCATCTCTGGAGTGGATTTTGAAT
ATTTGTAGCCCTTTTGCCTTTACTACTGGAATGATTCAGATTATCAAACTGGATTATAACTTGAATGGTGTAATTTTTCCTGACCCTTCA
GGAGACTCATATACAATGATAGCAACTTTTTCTATGTTGCTTTTGGATGGTCTCATCTACTTGCTATTGGCATTATACTTTGACAAAATT
TTACCCTATGGAGATGAGCGCCATTATTCTCCTTTATTTTTCTTGAATTCATCATCTTGTTTCCAACACCAAAGGACTAATGCTAAGGTT
ATTGAGAAAGAAATCGATGCTGAGCATCCCTCTGATGATTATTTTGAACCAGTAGCTCCTGAATTCCAAGGAAAAGAAGCCATCAGAATC
AGAAATGTTAAGAAGGAATATAAAGGAAAATCTGGAAAAGTGGAAGCATTGAAAGGCTTGCTCTTTGACATATATGAAGGTCAAATCACG
GCAATCCTGGGTCACAGTGGAGCTGGCAAATCTTCACTGCTAAATATTCTTAATGGATTGTCTGTTCCAACAGAAGGATCAGTTACCATC
TATAATAAAAATCTCTCTGAAATGCAAGACTTGGAGGAAATCAGAAAGATAACTGGCGTCTGTCCTCAATTCAATGTTCAATTTGACATA
CTCACCGTGAAGGAAAACCTCAGCCTGTTTGCTAAAATAAAAGGGATTCATCTAAAGGAAGTGGAACAAGAGGTACAACGAATATTATTG
GAATTGGACATGCAAAACATTCAAGATAACCTTGCTAAACATTTAAGTGAAGGACAGAAAAGAAAGCTGACTTTTGGGATTACCATTTTA
GGAGATCCTCAAATTTTGCTTTTAGATGAACCAACTACTGGATTGGATCCCTTTTCCAGAGATCAAGTGTGGAGCCTCCTGAGAGAGCGT
AGAGCAGATCATGTGATCCTTTTCAGTACCCAGTCCATGGATGAGGCTGACATCCTGGCTGATAGAAAAGTGATCATGTCCAATGGGAGA
CTGAAGTGTGCAGGTTCTTCTATGTTTTTGAAAAGAAGGTGGGGTCTTGGATATCACCTAAGTTTACATAGGAATGAAATATGTAACCCA
GAACAAATAACATCCTTCATTACTCATCACATCCCCGATGCTAAATTAAAAACAGAAAACAAAGAAAAGCTTGTATATACTTTGCCACTG
GAAAGGACAAATACATTTCCAGATCTTTTCAGTGATCTGGATAAGTGTTCTGACCAGGGAGTGACAGGTTATGACATTTCCATGTCAACT
CTAAATGAAGTCTTTATGAAACTGGAAGGACAGTCAACTATCGAACAAGATTTCGAACAAGTGGAGATGATAAGAGACTCAGAAAGCCTC
AATGAAATGGAGCTGGCTCACTCTTCCTTCTCTGAAATGCAGACAGCTGTGAGTGACATGGGCCTCTGGAGAATGCAAGTCTTTGCCATG
GCACGGCTCCGTTTCTTAAAGTTAAAACGTCAAACTAAAGTGTTATTGACCCTATTATTGGTATTTGGAATCGCAATATTCCCTTTGATT
GTTGAAAATATAATGTATGCTATGTTAAATGAAAAGATCGATTGGGAATTTAAAAACGAATTGTATTTTCTCTCTCCTGGACAACTTCCC
CAGGAACCCCGTACCAGCCTGTTGATCATCAATAACACAGAATCAAATATTGAAGATTTTATAAAATCACTGAAGCATCAAAATATACTT
TTGGAAGTAGATGACTTTGAAAACAGAAATGGTACTGATGGCCTCTCATACAATGGAGCTATCATAGTTTCTGGTAAACAAAAGGATTAT
AGATTTTCAGTTGTGTGTAATACCAAGAGATTGCACTGTTTTCCAATTCTTATGAATATTATCAGCAATGGGCTACTTCAAATGTTTAAT
CACACACAACATATTCGAATTGAGTCAAGCCCATTTCCTCTTAGCCACATAGGACTCTGGACTGGGTTGCCGGATGGTTCCTTTTTCTTA
TTTTTGGTTCTATGTAGCATTTCTCCTTATATCACCATGGGCAGCATCAGTGATTACAAGAAAAATGCTAAGTCCCAGCTATGGATTTCA
GGCCTCTACACTTCTGCTTACTGGTGTGGGCAGGCACTAGTGGACGTCAGCTTCTTCATTTTAATTCTCCTTTTAATGTATTTAATTTTC
TACATAGAAAACATGCAGTACCTTCTTATTACAAGCCAAATTGTGTTTGCTTTGGTTATAGTTACTCCTGGTTATGCAGCTTCTCTTGTC
TTCTTCATATATATGATATCATTTATTTTTCGCAAAAGGAGAAAAAACAGTGGCCTTTGGTCATTTTACTTCTTTTTTGCCTCCACCATC
ATGTTTTCCATCACTTTAATCAATCATTTTGACCTAAGTATATTGATTACCACCATGGTATTGGTTCCTTCATATACCTTGCTTGGATTT
AAAACTTTTTTGGAAGTGAGAGACCAGGAGCACTACAGAGAATTTCCAGAGGCAAATTTTGAATTGAGTGCCACTGATTTTCTAGTCTGC
TTCATACCCTACTTTCAGACTTTGCTATTCGTTTTTGTTCTAAGATGCATGGAACTAAAATGTGGAAAGAAAAGAATGCGAAAAGATCCT
GTTTTCAGAATTTCCCCCCAAAGTAGAGATGCTAAGCCAAATCCAGAAGAACCCATAGATGAAGATGAAGATATTCAAACAGAAAGAATA
AGAACAGCCACTGCTCTGACCACTTCAATCTTAGATGAGAAACCTGTTATAATTGCCAGCTGTCTACACAAAGAATATGCAGGCCAGAAG
AAAAGTTGCTTTTCAAAGAGGAAGAAGAAAATAGCAGCAAGAAATATCTCTTTCTGTGTTCAAGAAGGTGAAATTTTGGGATTGCTAGGA
CCCAATGGTGCTGGAAAAAGTTCATCTATTAGAATGATATCTGGGATCACAAAGCCAACTGCTGGAGAGGTGGAACTGAAAGGCTGCAGT
TCAGTTTTGGGCCACCTGGGGTACTGCCCTCAAGAGAACGTGCTGTGGCCCATGCTGACGTTGAGGGAACACCTGGAGGTGTATGCTGCC
GTCAAGGGGCTCAGGAAAGCGGACGCGAGGCTCGCCATCGCAAGATTAGTGAGTGCTTTCAAACTGCATGAGCAGCTGAATGTTCCTGTG
CAGAAATTAACAGCAGGAATCACGAGAAAGTTGTGTTTTGTGCTGAGCCTCCTGGGAAACTCACCTGTCTTGCTCCTGGATGAACCATCT
ACGGGCATAGACCCCACAGGGCAGCAGCAAATGTGGCAGGCAATCCAGGCAGTCGTTAAAAACACAGAGAGAGGTGTCCTCCTGACCACC
CATAACCTGGCTGAGGCGGAAGCCTTGTGTGACCGTGTGGCCATCATGGTGTCTGGAAGGCTTAGATGCATTGGCTCCATCCAACACCTG
AAAAACAAACTTGGCAAGGATTACATTCTAGAGCTAAAAGTGAAGGAAACGTCTCAAGTGACTTTGGTCCACACTGAGATTCTGAAGCTT
TTCCCACAGGCTGCAGGGCAGGAAAGGTATTCCTCTTTGTTAACCTATAAGCTGCCCGTGGCAGACGTTTACCCTCTATCACAGACCTTT
CACAAATTAGAAGCAGTGAAGCATAACTTTAACCTGGAAGAATACAGCCTTTCTCAGTGCACACTGGAGAAGGTATTCTTAGAGCTTTCT
AAAGAACAGGAAGTAGGAAATTTTGATGAAGAAATTGATACAACAATGAGATGGAAACTCCTCCCTCATTCAGATGAACCTTAAAACCTC
AAACCTAGTAATTTTTTGTTGATCTCCTATAAACTCATGTTTTATGTAATAATTAATAGTATGTTTAATTTTAAAGATCATTTAAAATTA
ACATCAGGTATATTTTGTAAATTTAGTTAACAAATACATAAATTTTAAAATTATTCTTCCTCTCAAACATAGGGGTGATAGCAAACCTGT

>29626_29626_1_FBXL20-ABCA6_FBXL20_chr17_37557614_ENST00000264658_ABCA6_chr17_67124945_ENST00000284425_length(amino acids)=1320AA_BP=168
MRRDVNGVTKSRFEVALVFLMSVLLKKAVLTNLVVFLLTLFWGCLGFTVFYEQLPSSLEWILNICSPFAFTTGMIQIIKLDYNLNGVIFP
DPSGDSYTMIATFSMLLLDGLIYLLLALYFDKILPYGDERHYSPLFFLNSSSCFQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGKEA
IRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQ
FDILTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLL
RERRADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHRNEICNPEQITSFITHHIPDAKLKTENKEKLVYT
LPLERTNTFPDLFSDLDKCSDQGVTGYDISMSTLNEVFMKLEGQSTIEQDFEQVEMIRDSESLNEMELAHSSFSEMQTAVSDMGLWRMQV
FAMARLRFLKLKRQTKVLLTLLLVFGIAIFPLIVENIMYAMLNEKIDWEFKNELYFLSPGQLPQEPRTSLLIINNTESNIEDFIKSLKHQ
NILLEVDDFENRNGTDGLSYNGAIIVSGKQKDYRFSVVCNTKRLHCFPILMNIISNGLLQMFNHTQHIRIESSPFPLSHIGLWTGLPDGS
FFLFLVLCSISPYITMGSISDYKKNAKSQLWISGLYTSAYWCGQALVDVSFFILILLLMYLIFYIENMQYLLITSQIVFALVIVTPGYAA
SLVFFIYMISFIFRKRRKNSGLWSFYFFFASTIMFSITLINHFDLSILITTMVLVPSYTLLGFKTFLEVRDQEHYREFPEANFELSATDF
LVCFIPYFQTLLFVFVLRCMELKCGKKRMRKDPVFRISPQSRDAKPNPEEPIDEDEDIQTERIRTATALTTSILDEKPVIIASCLHKEYA
GQKKSCFSKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKGCSSVLGHLGYCPQENVLWPMLTLREHLEV
YAAVKGLRKADARLAIARLVSAFKLHEQLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVL
LTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQVTLVHTEILKLFPQAAGQERYSSLLTYKLPVADVYPLS

--------------------------------------------------------------
>29626_29626_2_FBXL20-ABCA6_FBXL20_chr17_37557614_ENST00000394294_ABCA6_chr17_67124945_ENST00000284425_length(transcript)=4455nt_BP=263nt
GAGAGCCGAGCTAGCGACGAGCAGTCGTTGCGGCCGCCGGCGCCGCGGGAGGTGGTGGAGGCCTAGCCGGAGCCGAGAGGTCTCTTGTTC
CCGTCCCACGGTCCCGGCGTCACCCCTCCGGCGCCCAGTCCCCGTCCCGGAACTCCCGGGCCTGTCCTGGGCCCCCGGTCTGTGCACTCC
GCTCGCCGCAGCGCCCGGCCCGGGCCGCACCCGCCGGCCCCATGAGGAGGGACGTGAACGGAGTGACCAAGAGCAGGTTTGAGGTAGCTT
TGGTGTTCCTGATGAGTGTGCTGTTAAAGAAAGCTGTCCTCACCAATTTGGTTGTGTTTCTCCTTACCCTCTTTTGGGGATGTCTGGGAT
TCACTGTATTTTATGAACAACTTCCTTCATCTCTGGAGTGGATTTTGAATATTTGTAGCCCTTTTGCCTTTACTACTGGAATGATTCAGA
TTATCAAACTGGATTATAACTTGAATGGTGTAATTTTTCCTGACCCTTCAGGAGACTCATATACAATGATAGCAACTTTTTCTATGTTGC
TTTTGGATGGTCTCATCTACTTGCTATTGGCATTATACTTTGACAAAATTTTACCCTATGGAGATGAGCGCCATTATTCTCCTTTATTTT
TCTTGAATTCATCATCTTGTTTCCAACACCAAAGGACTAATGCTAAGGTTATTGAGAAAGAAATCGATGCTGAGCATCCCTCTGATGATT
ATTTTGAACCAGTAGCTCCTGAATTCCAAGGAAAAGAAGCCATCAGAATCAGAAATGTTAAGAAGGAATATAAAGGAAAATCTGGAAAAG
TGGAAGCATTGAAAGGCTTGCTCTTTGACATATATGAAGGTCAAATCACGGCAATCCTGGGTCACAGTGGAGCTGGCAAATCTTCACTGC
TAAATATTCTTAATGGATTGTCTGTTCCAACAGAAGGATCAGTTACCATCTATAATAAAAATCTCTCTGAAATGCAAGACTTGGAGGAAA
TCAGAAAGATAACTGGCGTCTGTCCTCAATTCAATGTTCAATTTGACATACTCACCGTGAAGGAAAACCTCAGCCTGTTTGCTAAAATAA
AAGGGATTCATCTAAAGGAAGTGGAACAAGAGGTACAACGAATATTATTGGAATTGGACATGCAAAACATTCAAGATAACCTTGCTAAAC
ATTTAAGTGAAGGACAGAAAAGAAAGCTGACTTTTGGGATTACCATTTTAGGAGATCCTCAAATTTTGCTTTTAGATGAACCAACTACTG
GATTGGATCCCTTTTCCAGAGATCAAGTGTGGAGCCTCCTGAGAGAGCGTAGAGCAGATCATGTGATCCTTTTCAGTACCCAGTCCATGG
ATGAGGCTGACATCCTGGCTGATAGAAAAGTGATCATGTCCAATGGGAGACTGAAGTGTGCAGGTTCTTCTATGTTTTTGAAAAGAAGGT
GGGGTCTTGGATATCACCTAAGTTTACATAGGAATGAAATATGTAACCCAGAACAAATAACATCCTTCATTACTCATCACATCCCCGATG
CTAAATTAAAAACAGAAAACAAAGAAAAGCTTGTATATACTTTGCCACTGGAAAGGACAAATACATTTCCAGATCTTTTCAGTGATCTGG
ATAAGTGTTCTGACCAGGGAGTGACAGGTTATGACATTTCCATGTCAACTCTAAATGAAGTCTTTATGAAACTGGAAGGACAGTCAACTA
TCGAACAAGATTTCGAACAAGTGGAGATGATAAGAGACTCAGAAAGCCTCAATGAAATGGAGCTGGCTCACTCTTCCTTCTCTGAAATGC
AGACAGCTGTGAGTGACATGGGCCTCTGGAGAATGCAAGTCTTTGCCATGGCACGGCTCCGTTTCTTAAAGTTAAAACGTCAAACTAAAG
TGTTATTGACCCTATTATTGGTATTTGGAATCGCAATATTCCCTTTGATTGTTGAAAATATAATGTATGCTATGTTAAATGAAAAGATCG
ATTGGGAATTTAAAAACGAATTGTATTTTCTCTCTCCTGGACAACTTCCCCAGGAACCCCGTACCAGCCTGTTGATCATCAATAACACAG
AATCAAATATTGAAGATTTTATAAAATCACTGAAGCATCAAAATATACTTTTGGAAGTAGATGACTTTGAAAACAGAAATGGTACTGATG
GCCTCTCATACAATGGAGCTATCATAGTTTCTGGTAAACAAAAGGATTATAGATTTTCAGTTGTGTGTAATACCAAGAGATTGCACTGTT
TTCCAATTCTTATGAATATTATCAGCAATGGGCTACTTCAAATGTTTAATCACACACAACATATTCGAATTGAGTCAAGCCCATTTCCTC
TTAGCCACATAGGACTCTGGACTGGGTTGCCGGATGGTTCCTTTTTCTTATTTTTGGTTCTATGTAGCATTTCTCCTTATATCACCATGG
GCAGCATCAGTGATTACAAGAAAAATGCTAAGTCCCAGCTATGGATTTCAGGCCTCTACACTTCTGCTTACTGGTGTGGGCAGGCACTAG
TGGACGTCAGCTTCTTCATTTTAATTCTCCTTTTAATGTATTTAATTTTCTACATAGAAAACATGCAGTACCTTCTTATTACAAGCCAAA
TTGTGTTTGCTTTGGTTATAGTTACTCCTGGTTATGCAGCTTCTCTTGTCTTCTTCATATATATGATATCATTTATTTTTCGCAAAAGGA
GAAAAAACAGTGGCCTTTGGTCATTTTACTTCTTTTTTGCCTCCACCATCATGTTTTCCATCACTTTAATCAATCATTTTGACCTAAGTA
TATTGATTACCACCATGGTATTGGTTCCTTCATATACCTTGCTTGGATTTAAAACTTTTTTGGAAGTGAGAGACCAGGAGCACTACAGAG
AATTTCCAGAGGCAAATTTTGAATTGAGTGCCACTGATTTTCTAGTCTGCTTCATACCCTACTTTCAGACTTTGCTATTCGTTTTTGTTC
TAAGATGCATGGAACTAAAATGTGGAAAGAAAAGAATGCGAAAAGATCCTGTTTTCAGAATTTCCCCCCAAAGTAGAGATGCTAAGCCAA
ATCCAGAAGAACCCATAGATGAAGATGAAGATATTCAAACAGAAAGAATAAGAACAGCCACTGCTCTGACCACTTCAATCTTAGATGAGA
AACCTGTTATAATTGCCAGCTGTCTACACAAAGAATATGCAGGCCAGAAGAAAAGTTGCTTTTCAAAGAGGAAGAAGAAAATAGCAGCAA
GAAATATCTCTTTCTGTGTTCAAGAAGGTGAAATTTTGGGATTGCTAGGACCCAATGGTGCTGGAAAAAGTTCATCTATTAGAATGATAT
CTGGGATCACAAAGCCAACTGCTGGAGAGGTGGAACTGAAAGGCTGCAGTTCAGTTTTGGGCCACCTGGGGTACTGCCCTCAAGAGAACG
TGCTGTGGCCCATGCTGACGTTGAGGGAACACCTGGAGGTGTATGCTGCCGTCAAGGGGCTCAGGAAAGCGGACGCGAGGCTCGCCATCG
CAAGATTAGTGAGTGCTTTCAAACTGCATGAGCAGCTGAATGTTCCTGTGCAGAAATTAACAGCAGGAATCACGAGAAAGTTGTGTTTTG
TGCTGAGCCTCCTGGGAAACTCACCTGTCTTGCTCCTGGATGAACCATCTACGGGCATAGACCCCACAGGGCAGCAGCAAATGTGGCAGG
CAATCCAGGCAGTCGTTAAAAACACAGAGAGAGGTGTCCTCCTGACCACCCATAACCTGGCTGAGGCGGAAGCCTTGTGTGACCGTGTGG
CCATCATGGTGTCTGGAAGGCTTAGATGCATTGGCTCCATCCAACACCTGAAAAACAAACTTGGCAAGGATTACATTCTAGAGCTAAAAG
TGAAGGAAACGTCTCAAGTGACTTTGGTCCACACTGAGATTCTGAAGCTTTTCCCACAGGCTGCAGGGCAGGAAAGGTATTCCTCTTTGT
TAACCTATAAGCTGCCCGTGGCAGACGTTTACCCTCTATCACAGACCTTTCACAAATTAGAAGCAGTGAAGCATAACTTTAACCTGGAAG
AATACAGCCTTTCTCAGTGCACACTGGAGAAGGTATTCTTAGAGCTTTCTAAAGAACAGGAAGTAGGAAATTTTGATGAAGAAATTGATA
CAACAATGAGATGGAAACTCCTCCCTCATTCAGATGAACCTTAAAACCTCAAACCTAGTAATTTTTTGTTGATCTCCTATAAACTCATGT
TTTATGTAATAATTAATAGTATGTTTAATTTTAAAGATCATTTAAAATTAACATCAGGTATATTTTGTAAATTTAGTTAACAAATACATA
AATTTTAAAATTATTCTTCCTCTCAAACATAGGGGTGATAGCAAACCTGTGATAAAGGCAATACAAAATATTAGTAAAGTCACCCAAAGA

>29626_29626_2_FBXL20-ABCA6_FBXL20_chr17_37557614_ENST00000394294_ABCA6_chr17_67124945_ENST00000284425_length(amino acids)=1320AA_BP=168
MRRDVNGVTKSRFEVALVFLMSVLLKKAVLTNLVVFLLTLFWGCLGFTVFYEQLPSSLEWILNICSPFAFTTGMIQIIKLDYNLNGVIFP
DPSGDSYTMIATFSMLLLDGLIYLLLALYFDKILPYGDERHYSPLFFLNSSSCFQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGKEA
IRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQ
FDILTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLL
RERRADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHRNEICNPEQITSFITHHIPDAKLKTENKEKLVYT
LPLERTNTFPDLFSDLDKCSDQGVTGYDISMSTLNEVFMKLEGQSTIEQDFEQVEMIRDSESLNEMELAHSSFSEMQTAVSDMGLWRMQV
FAMARLRFLKLKRQTKVLLTLLLVFGIAIFPLIVENIMYAMLNEKIDWEFKNELYFLSPGQLPQEPRTSLLIINNTESNIEDFIKSLKHQ
NILLEVDDFENRNGTDGLSYNGAIIVSGKQKDYRFSVVCNTKRLHCFPILMNIISNGLLQMFNHTQHIRIESSPFPLSHIGLWTGLPDGS
FFLFLVLCSISPYITMGSISDYKKNAKSQLWISGLYTSAYWCGQALVDVSFFILILLLMYLIFYIENMQYLLITSQIVFALVIVTPGYAA
SLVFFIYMISFIFRKRRKNSGLWSFYFFFASTIMFSITLINHFDLSILITTMVLVPSYTLLGFKTFLEVRDQEHYREFPEANFELSATDF
LVCFIPYFQTLLFVFVLRCMELKCGKKRMRKDPVFRISPQSRDAKPNPEEPIDEDEDIQTERIRTATALTTSILDEKPVIIASCLHKEYA
GQKKSCFSKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKGCSSVLGHLGYCPQENVLWPMLTLREHLEV
YAAVKGLRKADARLAIARLVSAFKLHEQLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVL
LTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQVTLVHTEILKLFPQAAGQERYSSLLTYKLPVADVYPLS

--------------------------------------------------------------
>29626_29626_3_FBXL20-ABCA6_FBXL20_chr17_37557614_ENST00000583610_ABCA6_chr17_67124945_ENST00000284425_length(transcript)=4488nt_BP=296nt
GTTTTTGTTTTGGGTTGAAGTTGAGGCTGAGGAGAGAGCCGAGCTAGCGACGAGCAGTCGTTGCGGCCGCCGGCGCCGCGGGAGGTGGTG
GAGGCCTAGCCGGAGCCGAGAGGTCTCTTGTTCCCGTCCCACGGTCCCGGCGTCACCCCTCCGGCGCCCAGTCCCCGTCCCGGAACTCCC
GGGCCTGTCCTGGGCCCCCGGTCTGTGCACTCCGCTCGCCGCAGCGCCCGGCCCGGGCCGCACCCGCCGGCCCCATGAGGAGGGACGTGA
ACGGAGTGACCAAGAGCAGGTTTGAGGTAGCTTTGGTGTTCCTGATGAGTGTGCTGTTAAAGAAAGCTGTCCTCACCAATTTGGTTGTGT
TTCTCCTTACCCTCTTTTGGGGATGTCTGGGATTCACTGTATTTTATGAACAACTTCCTTCATCTCTGGAGTGGATTTTGAATATTTGTA
GCCCTTTTGCCTTTACTACTGGAATGATTCAGATTATCAAACTGGATTATAACTTGAATGGTGTAATTTTTCCTGACCCTTCAGGAGACT
CATATACAATGATAGCAACTTTTTCTATGTTGCTTTTGGATGGTCTCATCTACTTGCTATTGGCATTATACTTTGACAAAATTTTACCCT
ATGGAGATGAGCGCCATTATTCTCCTTTATTTTTCTTGAATTCATCATCTTGTTTCCAACACCAAAGGACTAATGCTAAGGTTATTGAGA
AAGAAATCGATGCTGAGCATCCCTCTGATGATTATTTTGAACCAGTAGCTCCTGAATTCCAAGGAAAAGAAGCCATCAGAATCAGAAATG
TTAAGAAGGAATATAAAGGAAAATCTGGAAAAGTGGAAGCATTGAAAGGCTTGCTCTTTGACATATATGAAGGTCAAATCACGGCAATCC
TGGGTCACAGTGGAGCTGGCAAATCTTCACTGCTAAATATTCTTAATGGATTGTCTGTTCCAACAGAAGGATCAGTTACCATCTATAATA
AAAATCTCTCTGAAATGCAAGACTTGGAGGAAATCAGAAAGATAACTGGCGTCTGTCCTCAATTCAATGTTCAATTTGACATACTCACCG
TGAAGGAAAACCTCAGCCTGTTTGCTAAAATAAAAGGGATTCATCTAAAGGAAGTGGAACAAGAGGTACAACGAATATTATTGGAATTGG
ACATGCAAAACATTCAAGATAACCTTGCTAAACATTTAAGTGAAGGACAGAAAAGAAAGCTGACTTTTGGGATTACCATTTTAGGAGATC
CTCAAATTTTGCTTTTAGATGAACCAACTACTGGATTGGATCCCTTTTCCAGAGATCAAGTGTGGAGCCTCCTGAGAGAGCGTAGAGCAG
ATCATGTGATCCTTTTCAGTACCCAGTCCATGGATGAGGCTGACATCCTGGCTGATAGAAAAGTGATCATGTCCAATGGGAGACTGAAGT
GTGCAGGTTCTTCTATGTTTTTGAAAAGAAGGTGGGGTCTTGGATATCACCTAAGTTTACATAGGAATGAAATATGTAACCCAGAACAAA
TAACATCCTTCATTACTCATCACATCCCCGATGCTAAATTAAAAACAGAAAACAAAGAAAAGCTTGTATATACTTTGCCACTGGAAAGGA
CAAATACATTTCCAGATCTTTTCAGTGATCTGGATAAGTGTTCTGACCAGGGAGTGACAGGTTATGACATTTCCATGTCAACTCTAAATG
AAGTCTTTATGAAACTGGAAGGACAGTCAACTATCGAACAAGATTTCGAACAAGTGGAGATGATAAGAGACTCAGAAAGCCTCAATGAAA
TGGAGCTGGCTCACTCTTCCTTCTCTGAAATGCAGACAGCTGTGAGTGACATGGGCCTCTGGAGAATGCAAGTCTTTGCCATGGCACGGC
TCCGTTTCTTAAAGTTAAAACGTCAAACTAAAGTGTTATTGACCCTATTATTGGTATTTGGAATCGCAATATTCCCTTTGATTGTTGAAA
ATATAATGTATGCTATGTTAAATGAAAAGATCGATTGGGAATTTAAAAACGAATTGTATTTTCTCTCTCCTGGACAACTTCCCCAGGAAC
CCCGTACCAGCCTGTTGATCATCAATAACACAGAATCAAATATTGAAGATTTTATAAAATCACTGAAGCATCAAAATATACTTTTGGAAG
TAGATGACTTTGAAAACAGAAATGGTACTGATGGCCTCTCATACAATGGAGCTATCATAGTTTCTGGTAAACAAAAGGATTATAGATTTT
CAGTTGTGTGTAATACCAAGAGATTGCACTGTTTTCCAATTCTTATGAATATTATCAGCAATGGGCTACTTCAAATGTTTAATCACACAC
AACATATTCGAATTGAGTCAAGCCCATTTCCTCTTAGCCACATAGGACTCTGGACTGGGTTGCCGGATGGTTCCTTTTTCTTATTTTTGG
TTCTATGTAGCATTTCTCCTTATATCACCATGGGCAGCATCAGTGATTACAAGAAAAATGCTAAGTCCCAGCTATGGATTTCAGGCCTCT
ACACTTCTGCTTACTGGTGTGGGCAGGCACTAGTGGACGTCAGCTTCTTCATTTTAATTCTCCTTTTAATGTATTTAATTTTCTACATAG
AAAACATGCAGTACCTTCTTATTACAAGCCAAATTGTGTTTGCTTTGGTTATAGTTACTCCTGGTTATGCAGCTTCTCTTGTCTTCTTCA
TATATATGATATCATTTATTTTTCGCAAAAGGAGAAAAAACAGTGGCCTTTGGTCATTTTACTTCTTTTTTGCCTCCACCATCATGTTTT
CCATCACTTTAATCAATCATTTTGACCTAAGTATATTGATTACCACCATGGTATTGGTTCCTTCATATACCTTGCTTGGATTTAAAACTT
TTTTGGAAGTGAGAGACCAGGAGCACTACAGAGAATTTCCAGAGGCAAATTTTGAATTGAGTGCCACTGATTTTCTAGTCTGCTTCATAC
CCTACTTTCAGACTTTGCTATTCGTTTTTGTTCTAAGATGCATGGAACTAAAATGTGGAAAGAAAAGAATGCGAAAAGATCCTGTTTTCA
GAATTTCCCCCCAAAGTAGAGATGCTAAGCCAAATCCAGAAGAACCCATAGATGAAGATGAAGATATTCAAACAGAAAGAATAAGAACAG
CCACTGCTCTGACCACTTCAATCTTAGATGAGAAACCTGTTATAATTGCCAGCTGTCTACACAAAGAATATGCAGGCCAGAAGAAAAGTT
GCTTTTCAAAGAGGAAGAAGAAAATAGCAGCAAGAAATATCTCTTTCTGTGTTCAAGAAGGTGAAATTTTGGGATTGCTAGGACCCAATG
GTGCTGGAAAAAGTTCATCTATTAGAATGATATCTGGGATCACAAAGCCAACTGCTGGAGAGGTGGAACTGAAAGGCTGCAGTTCAGTTT
TGGGCCACCTGGGGTACTGCCCTCAAGAGAACGTGCTGTGGCCCATGCTGACGTTGAGGGAACACCTGGAGGTGTATGCTGCCGTCAAGG
GGCTCAGGAAAGCGGACGCGAGGCTCGCCATCGCAAGATTAGTGAGTGCTTTCAAACTGCATGAGCAGCTGAATGTTCCTGTGCAGAAAT
TAACAGCAGGAATCACGAGAAAGTTGTGTTTTGTGCTGAGCCTCCTGGGAAACTCACCTGTCTTGCTCCTGGATGAACCATCTACGGGCA
TAGACCCCACAGGGCAGCAGCAAATGTGGCAGGCAATCCAGGCAGTCGTTAAAAACACAGAGAGAGGTGTCCTCCTGACCACCCATAACC
TGGCTGAGGCGGAAGCCTTGTGTGACCGTGTGGCCATCATGGTGTCTGGAAGGCTTAGATGCATTGGCTCCATCCAACACCTGAAAAACA
AACTTGGCAAGGATTACATTCTAGAGCTAAAAGTGAAGGAAACGTCTCAAGTGACTTTGGTCCACACTGAGATTCTGAAGCTTTTCCCAC
AGGCTGCAGGGCAGGAAAGGTATTCCTCTTTGTTAACCTATAAGCTGCCCGTGGCAGACGTTTACCCTCTATCACAGACCTTTCACAAAT
TAGAAGCAGTGAAGCATAACTTTAACCTGGAAGAATACAGCCTTTCTCAGTGCACACTGGAGAAGGTATTCTTAGAGCTTTCTAAAGAAC
AGGAAGTAGGAAATTTTGATGAAGAAATTGATACAACAATGAGATGGAAACTCCTCCCTCATTCAGATGAACCTTAAAACCTCAAACCTA
GTAATTTTTTGTTGATCTCCTATAAACTCATGTTTTATGTAATAATTAATAGTATGTTTAATTTTAAAGATCATTTAAAATTAACATCAG
GTATATTTTGTAAATTTAGTTAACAAATACATAAATTTTAAAATTATTCTTCCTCTCAAACATAGGGGTGATAGCAAACCTGTGATAAAG

>29626_29626_3_FBXL20-ABCA6_FBXL20_chr17_37557614_ENST00000583610_ABCA6_chr17_67124945_ENST00000284425_length(amino acids)=1320AA_BP=168
MRRDVNGVTKSRFEVALVFLMSVLLKKAVLTNLVVFLLTLFWGCLGFTVFYEQLPSSLEWILNICSPFAFTTGMIQIIKLDYNLNGVIFP
DPSGDSYTMIATFSMLLLDGLIYLLLALYFDKILPYGDERHYSPLFFLNSSSCFQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGKEA
IRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQ
FDILTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLL
RERRADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHRNEICNPEQITSFITHHIPDAKLKTENKEKLVYT
LPLERTNTFPDLFSDLDKCSDQGVTGYDISMSTLNEVFMKLEGQSTIEQDFEQVEMIRDSESLNEMELAHSSFSEMQTAVSDMGLWRMQV
FAMARLRFLKLKRQTKVLLTLLLVFGIAIFPLIVENIMYAMLNEKIDWEFKNELYFLSPGQLPQEPRTSLLIINNTESNIEDFIKSLKHQ
NILLEVDDFENRNGTDGLSYNGAIIVSGKQKDYRFSVVCNTKRLHCFPILMNIISNGLLQMFNHTQHIRIESSPFPLSHIGLWTGLPDGS
FFLFLVLCSISPYITMGSISDYKKNAKSQLWISGLYTSAYWCGQALVDVSFFILILLLMYLIFYIENMQYLLITSQIVFALVIVTPGYAA
SLVFFIYMISFIFRKRRKNSGLWSFYFFFASTIMFSITLINHFDLSILITTMVLVPSYTLLGFKTFLEVRDQEHYREFPEANFELSATDF
LVCFIPYFQTLLFVFVLRCMELKCGKKRMRKDPVFRISPQSRDAKPNPEEPIDEDEDIQTERIRTATALTTSILDEKPVIIASCLHKEYA
GQKKSCFSKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKGCSSVLGHLGYCPQENVLWPMLTLREHLEV
YAAVKGLRKADARLAIARLVSAFKLHEQLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVL
LTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQVTLVHTEILKLFPQAAGQERYSSLLTYKLPVADVYPLS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FBXL20-ABCA6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FBXL20-ABCA6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FBXL20-ABCA6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0009402Colorectal Carcinoma1CTD_human
TgeneC0009404Colorectal Neoplasms1CTD_human
TgeneC0162820Dermatitis, Allergic Contact1CTD_human