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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FBXL20-GRB7 (FusionGDB2 ID:HG84961TG2886)

Fusion Gene Summary for FBXL20-GRB7

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXL20-GRB7
Fusion gene ID: hg84961tg2886
HgeneTgene
Gene symbol

FBXL20

GRB7

Gene ID

84961

2886

Gene nameF-box and leucine rich repeat protein 20growth factor receptor bound protein 7
SynonymsFbl2|Fbl20-
Cytomap('FBXL20')('GRB7')

17q12

17q12

Type of geneprotein-codingprotein-coding
DescriptionF-box/LRR-repeat protein 20F-box protein FBL2growth factor receptor-bound protein 7B47GRB7 adapter proteinepidermal growth factor receptor GRB-7
Modification date2020031320200313
UniProtAcc.

Q14451

Ensembl transtripts involved in fusion geneENST00000264658, ENST00000394294, 
ENST00000577399, ENST00000583610, 
Fusion gene scores* DoF score58 X 21 X 16=1948811 X 4 X 6=264
# samples 6115
** MAII scorelog2(61/19488*10)=-4.99763298545608
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/264*10)=-0.815575428862573
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FBXL20 [Title/Abstract] AND GRB7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFBXL20(37558426)-GRB7(37898505), # samples:3
FBXL20(37557613)-GRB7(37898504), # samples:3
FBXL20(37557614)-GRB7(37898505), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGRB7

GO:0030335

positive regulation of cell migration

10893408|12021278



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-60-2715-01AFBXL20chr17

37557614

-GRB7chr17

37898505

+
ChimerDB4LUSCTCGA-60-2715-01AFBXL20chr17

37558426

-GRB7chr17

37898505

+
ChimerDB4LUSCTCGA-60-2715FBXL20chr17

37557613

-GRB7chr17

37898504

+
ChimerDB4READTCGA-AF-A56L-01AFBXL20chr17

37557614

-GRB7chr17

37898505

+
ChimerDB4READTCGA-AF-A56L-01AFBXL20chr17

37558426

-GRB7chr17

37898505

+
ChimerDB4READTCGA-AF-A56LFBXL20chr17

37557613

-GRB7chr17

37898504

+
ChimerDB4READTCGA-AF-A56LFBXL20chr17

37557614

-GRB7chr17

37898505

+
ChimerDB4READTCGA-AF-A56LFBXL20chr17

37558426

-GRB7chr17

37898505

+


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Fusion Gene ORF analysis for FBXL20-GRB7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000264658ENST00000445327FBXL20chr17

37557613

-GRB7chr17

37898504

+
5CDS-3UTRENST00000264658ENST00000445327FBXL20chr17

37557614

-GRB7chr17

37898505

+
5CDS-3UTRENST00000264658ENST00000578702FBXL20chr17

37557613

-GRB7chr17

37898504

+
5CDS-3UTRENST00000264658ENST00000578702FBXL20chr17

37557614

-GRB7chr17

37898505

+
5CDS-3UTRENST00000394294ENST00000445327FBXL20chr17

37557613

-GRB7chr17

37898504

+
5CDS-3UTRENST00000394294ENST00000445327FBXL20chr17

37557614

-GRB7chr17

37898505

+
5CDS-3UTRENST00000394294ENST00000578702FBXL20chr17

37557613

-GRB7chr17

37898504

+
5CDS-3UTRENST00000394294ENST00000578702FBXL20chr17

37557614

-GRB7chr17

37898505

+
5CDS-3UTRENST00000577399ENST00000445327FBXL20chr17

37558426

-GRB7chr17

37898505

+
5CDS-3UTRENST00000577399ENST00000578702FBXL20chr17

37558426

-GRB7chr17

37898505

+
5CDS-3UTRENST00000583610ENST00000445327FBXL20chr17

37557613

-GRB7chr17

37898504

+
5CDS-3UTRENST00000583610ENST00000445327FBXL20chr17

37557614

-GRB7chr17

37898505

+
5CDS-3UTRENST00000583610ENST00000578702FBXL20chr17

37557613

-GRB7chr17

37898504

+
5CDS-3UTRENST00000583610ENST00000578702FBXL20chr17

37557614

-GRB7chr17

37898505

+
5CDS-5UTRENST00000264658ENST00000309156FBXL20chr17

37557613

-GRB7chr17

37898504

+
5CDS-5UTRENST00000264658ENST00000309156FBXL20chr17

37557614

-GRB7chr17

37898505

+
5CDS-5UTRENST00000264658ENST00000309185FBXL20chr17

37557613

-GRB7chr17

37898504

+
5CDS-5UTRENST00000264658ENST00000309185FBXL20chr17

37557614

-GRB7chr17

37898505

+
5CDS-5UTRENST00000264658ENST00000394204FBXL20chr17

37557613

-GRB7chr17

37898504

+
5CDS-5UTRENST00000264658ENST00000394204FBXL20chr17

37557614

-GRB7chr17

37898505

+
5CDS-5UTRENST00000264658ENST00000394209FBXL20chr17

37557613

-GRB7chr17

37898504

+
5CDS-5UTRENST00000264658ENST00000394209FBXL20chr17

37557614

-GRB7chr17

37898505

+
5CDS-5UTRENST00000264658ENST00000394211FBXL20chr17

37557613

-GRB7chr17

37898504

+
5CDS-5UTRENST00000264658ENST00000394211FBXL20chr17

37557614

-GRB7chr17

37898505

+
5CDS-5UTRENST00000394294ENST00000309156FBXL20chr17

37557613

-GRB7chr17

37898504

+
5CDS-5UTRENST00000394294ENST00000309156FBXL20chr17

37557614

-GRB7chr17

37898505

+
5CDS-5UTRENST00000394294ENST00000309185FBXL20chr17

37557613

-GRB7chr17

37898504

+
5CDS-5UTRENST00000394294ENST00000309185FBXL20chr17

37557614

-GRB7chr17

37898505

+
5CDS-5UTRENST00000394294ENST00000394204FBXL20chr17

37557613

-GRB7chr17

37898504

+
5CDS-5UTRENST00000394294ENST00000394204FBXL20chr17

37557614

-GRB7chr17

37898505

+
5CDS-5UTRENST00000394294ENST00000394209FBXL20chr17

37557613

-GRB7chr17

37898504

+
5CDS-5UTRENST00000394294ENST00000394209FBXL20chr17

37557614

-GRB7chr17

37898505

+
5CDS-5UTRENST00000394294ENST00000394211FBXL20chr17

37557613

-GRB7chr17

37898504

+
5CDS-5UTRENST00000394294ENST00000394211FBXL20chr17

37557614

-GRB7chr17

37898505

+
5CDS-5UTRENST00000577399ENST00000309156FBXL20chr17

37558426

-GRB7chr17

37898505

+
5CDS-5UTRENST00000577399ENST00000309185FBXL20chr17

37558426

-GRB7chr17

37898505

+
5CDS-5UTRENST00000577399ENST00000394204FBXL20chr17

37558426

-GRB7chr17

37898505

+
5CDS-5UTRENST00000577399ENST00000394209FBXL20chr17

37558426

-GRB7chr17

37898505

+
5CDS-5UTRENST00000577399ENST00000394211FBXL20chr17

37558426

-GRB7chr17

37898505

+
5CDS-5UTRENST00000583610ENST00000309156FBXL20chr17

37557613

-GRB7chr17

37898504

+
5CDS-5UTRENST00000583610ENST00000309156FBXL20chr17

37557614

-GRB7chr17

37898505

+
5CDS-5UTRENST00000583610ENST00000309185FBXL20chr17

37557613

-GRB7chr17

37898504

+
5CDS-5UTRENST00000583610ENST00000309185FBXL20chr17

37557614

-GRB7chr17

37898505

+
5CDS-5UTRENST00000583610ENST00000394204FBXL20chr17

37557613

-GRB7chr17

37898504

+
5CDS-5UTRENST00000583610ENST00000394204FBXL20chr17

37557614

-GRB7chr17

37898505

+
5CDS-5UTRENST00000583610ENST00000394209FBXL20chr17

37557613

-GRB7chr17

37898504

+
5CDS-5UTRENST00000583610ENST00000394209FBXL20chr17

37557614

-GRB7chr17

37898505

+
5CDS-5UTRENST00000583610ENST00000394211FBXL20chr17

37557613

-GRB7chr17

37898504

+
5CDS-5UTRENST00000583610ENST00000394211FBXL20chr17

37557614

-GRB7chr17

37898505

+
intron-3UTRENST00000264658ENST00000445327FBXL20chr17

37558426

-GRB7chr17

37898505

+
intron-3UTRENST00000264658ENST00000578702FBXL20chr17

37558426

-GRB7chr17

37898505

+
intron-3UTRENST00000394294ENST00000445327FBXL20chr17

37558426

-GRB7chr17

37898505

+
intron-3UTRENST00000394294ENST00000578702FBXL20chr17

37558426

-GRB7chr17

37898505

+
intron-3UTRENST00000577399ENST00000445327FBXL20chr17

37557613

-GRB7chr17

37898504

+
intron-3UTRENST00000577399ENST00000445327FBXL20chr17

37557614

-GRB7chr17

37898505

+
intron-3UTRENST00000577399ENST00000578702FBXL20chr17

37557613

-GRB7chr17

37898504

+
intron-3UTRENST00000577399ENST00000578702FBXL20chr17

37557614

-GRB7chr17

37898505

+
intron-3UTRENST00000583610ENST00000445327FBXL20chr17

37558426

-GRB7chr17

37898505

+
intron-3UTRENST00000583610ENST00000578702FBXL20chr17

37558426

-GRB7chr17

37898505

+
intron-5UTRENST00000264658ENST00000309156FBXL20chr17

37558426

-GRB7chr17

37898505

+
intron-5UTRENST00000264658ENST00000309185FBXL20chr17

37558426

-GRB7chr17

37898505

+
intron-5UTRENST00000264658ENST00000394204FBXL20chr17

37558426

-GRB7chr17

37898505

+
intron-5UTRENST00000264658ENST00000394209FBXL20chr17

37558426

-GRB7chr17

37898505

+
intron-5UTRENST00000264658ENST00000394211FBXL20chr17

37558426

-GRB7chr17

37898505

+
intron-5UTRENST00000394294ENST00000309156FBXL20chr17

37558426

-GRB7chr17

37898505

+
intron-5UTRENST00000394294ENST00000309185FBXL20chr17

37558426

-GRB7chr17

37898505

+
intron-5UTRENST00000394294ENST00000394204FBXL20chr17

37558426

-GRB7chr17

37898505

+
intron-5UTRENST00000394294ENST00000394209FBXL20chr17

37558426

-GRB7chr17

37898505

+
intron-5UTRENST00000394294ENST00000394211FBXL20chr17

37558426

-GRB7chr17

37898505

+
intron-5UTRENST00000577399ENST00000309156FBXL20chr17

37557613

-GRB7chr17

37898504

+
intron-5UTRENST00000577399ENST00000309156FBXL20chr17

37557614

-GRB7chr17

37898505

+
intron-5UTRENST00000577399ENST00000309185FBXL20chr17

37557613

-GRB7chr17

37898504

+
intron-5UTRENST00000577399ENST00000309185FBXL20chr17

37557614

-GRB7chr17

37898505

+
intron-5UTRENST00000577399ENST00000394204FBXL20chr17

37557613

-GRB7chr17

37898504

+
intron-5UTRENST00000577399ENST00000394204FBXL20chr17

37557614

-GRB7chr17

37898505

+
intron-5UTRENST00000577399ENST00000394209FBXL20chr17

37557613

-GRB7chr17

37898504

+
intron-5UTRENST00000577399ENST00000394209FBXL20chr17

37557614

-GRB7chr17

37898505

+
intron-5UTRENST00000577399ENST00000394211FBXL20chr17

37557613

-GRB7chr17

37898504

+
intron-5UTRENST00000577399ENST00000394211FBXL20chr17

37557614

-GRB7chr17

37898505

+
intron-5UTRENST00000583610ENST00000309156FBXL20chr17

37558426

-GRB7chr17

37898505

+
intron-5UTRENST00000583610ENST00000309185FBXL20chr17

37558426

-GRB7chr17

37898505

+
intron-5UTRENST00000583610ENST00000394204FBXL20chr17

37558426

-GRB7chr17

37898505

+
intron-5UTRENST00000583610ENST00000394209FBXL20chr17

37558426

-GRB7chr17

37898505

+
intron-5UTRENST00000583610ENST00000394211FBXL20chr17

37558426

-GRB7chr17

37898505

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for FBXL20-GRB7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FBXL20chr1737558425-GRB7chr1737898504+0.0060876930.99391234
FBXL20chr1737558425-GRB7chr1737898504+0.0060876930.99391234
FBXL20chr1737558425-GRB7chr1737898504+0.0060876930.99391234
FBXL20chr1737557613-GRB7chr1737898504+7.75E-060.99999225
FBXL20chr1737557613-GRB7chr1737898504+7.75E-060.99999225
FBXL20chr1737558425-GRB7chr1737898504+0.0060876930.99391234
FBXL20chr1737558425-GRB7chr1737898504+0.0060876930.99391234
FBXL20chr1737558425-GRB7chr1737898504+0.0060876930.99391234
FBXL20chr1737557613-GRB7chr1737898504+7.75E-060.99999225
FBXL20chr1737557613-GRB7chr1737898504+7.75E-060.99999225


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FBXL20-GRB7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:37558426/:37898505)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GRB7

Q14451

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). {ECO:0000250, ECO:0000269|PubMed:10893408, ECO:0000269|PubMed:12021278, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:20622016}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FBXL20-GRB7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FBXL20-GRB7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FBXL20-GRB7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FBXL20-GRB7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0006142Malignant neoplasm of breast2CTD_human
TgeneC0678222Breast Carcinoma2CTD_human
TgeneC1257931Mammary Neoplasms, Human2CTD_human
TgeneC1458155Mammary Neoplasms2CTD_human
TgeneC4704874Mammary Carcinoma, Human2CTD_human
TgeneC0001418Adenocarcinoma1CTD_human
TgeneC0007134Renal Cell Carcinoma1CTD_human
TgeneC0024121Lung Neoplasms1CTD_human
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0205641Adenocarcinoma, Basal Cell1CTD_human
TgeneC0205642Adenocarcinoma, Oxyphilic1CTD_human
TgeneC0205643Carcinoma, Cribriform1CTD_human
TgeneC0205644Carcinoma, Granular Cell1CTD_human
TgeneC0205645Adenocarcinoma, Tubular1CTD_human
TgeneC0242379Malignant neoplasm of lung1CTD_human
TgeneC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
TgeneC0376358Malignant neoplasm of prostate1CTD_human
TgeneC1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneC1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneC1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneC1306837Papillary Renal Cell Carcinoma1CTD_human