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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:RUNX1T1-E2F5 (FusionGDB2 ID:HG862TG1875) |
Fusion Gene Summary for RUNX1T1-E2F5 |
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Fusion gene information | Fusion gene name: RUNX1T1-E2F5 | Fusion gene ID: hg862tg1875 | Hgene | Tgene | Gene symbol | RUNX1T1 | E2F5 | Gene ID | 862 | 1875 |
Gene name | RUNX1 partner transcriptional co-repressor 1 | E2F transcription factor 5 | |
Synonyms | AML1-MTG8|AML1T1|CBFA2T1|CDR|ETO|MTG8|ZMYND2 | E2F-5 | |
Cytomap | ('RUNX1T1')('E2F5') 8q21.3 | 8q21.2 | |
Type of gene | protein-coding | protein-coding | |
Description | protein CBFA2T1RUNX1 translocation partner 1acute myelogenous leukemia 1 translocation 1, cyclin-D relatedcore-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-relatedeight twenty one proteinmyeloid translocation gene on 8q2 | transcription factor E2F5E2F transcription factor 5, p130-binding | |
Modification date | 20200315 | 20200313 | |
UniProtAcc | Q06455 | Q15329 | |
Ensembl transtripts involved in fusion gene | ENST00000523629, ENST00000265814, ENST00000360348, ENST00000396218, ENST00000422361, ENST00000436581, ENST00000518844, ENST00000520724, ENST00000521553, ENST00000522163, | ||
Fusion gene scores | * DoF score | 12 X 31 X 5=1860 | 6 X 6 X 4=144 |
# samples | 27 | 7 | |
** MAII score | log2(27/1860*10)=-2.78427130894456 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: RUNX1T1 [Title/Abstract] AND E2F5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | RUNX1T1(93115085)-E2F5(86114382), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | RUNX1T1 | GO:0045892 | negative regulation of transcription, DNA-templated | 23251453 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | SARC | TCGA-DX-A3M1-01A | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
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Fusion Gene ORF analysis for RUNX1T1-E2F5 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000523629 | ENST00000256117 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
5UTR-3CDS | ENST00000523629 | ENST00000416274 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
5UTR-3CDS | ENST00000523629 | ENST00000418930 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
5UTR-3UTR | ENST00000523629 | ENST00000519128 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
5UTR-5UTR | ENST00000523629 | ENST00000517476 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
5UTR-5UTR | ENST00000523629 | ENST00000521429 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3CDS | ENST00000265814 | ENST00000256117 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3CDS | ENST00000265814 | ENST00000416274 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3CDS | ENST00000265814 | ENST00000418930 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3CDS | ENST00000360348 | ENST00000256117 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3CDS | ENST00000360348 | ENST00000416274 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3CDS | ENST00000360348 | ENST00000418930 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3CDS | ENST00000396218 | ENST00000256117 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3CDS | ENST00000396218 | ENST00000416274 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3CDS | ENST00000396218 | ENST00000418930 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3CDS | ENST00000422361 | ENST00000256117 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3CDS | ENST00000422361 | ENST00000416274 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3CDS | ENST00000422361 | ENST00000418930 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3CDS | ENST00000436581 | ENST00000256117 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3CDS | ENST00000436581 | ENST00000416274 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3CDS | ENST00000436581 | ENST00000418930 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3CDS | ENST00000518844 | ENST00000256117 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3CDS | ENST00000518844 | ENST00000416274 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3CDS | ENST00000518844 | ENST00000418930 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3CDS | ENST00000520724 | ENST00000256117 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3CDS | ENST00000520724 | ENST00000416274 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3CDS | ENST00000520724 | ENST00000418930 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3CDS | ENST00000521553 | ENST00000256117 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3CDS | ENST00000521553 | ENST00000416274 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3CDS | ENST00000521553 | ENST00000418930 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3CDS | ENST00000522163 | ENST00000256117 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3CDS | ENST00000522163 | ENST00000416274 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3CDS | ENST00000522163 | ENST00000418930 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3UTR | ENST00000265814 | ENST00000519128 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3UTR | ENST00000360348 | ENST00000519128 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3UTR | ENST00000396218 | ENST00000519128 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3UTR | ENST00000422361 | ENST00000519128 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3UTR | ENST00000436581 | ENST00000519128 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3UTR | ENST00000518844 | ENST00000519128 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3UTR | ENST00000520724 | ENST00000519128 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3UTR | ENST00000521553 | ENST00000519128 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-3UTR | ENST00000522163 | ENST00000519128 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-5UTR | ENST00000265814 | ENST00000517476 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-5UTR | ENST00000265814 | ENST00000521429 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-5UTR | ENST00000360348 | ENST00000517476 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-5UTR | ENST00000360348 | ENST00000521429 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-5UTR | ENST00000396218 | ENST00000517476 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-5UTR | ENST00000396218 | ENST00000521429 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-5UTR | ENST00000422361 | ENST00000517476 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-5UTR | ENST00000422361 | ENST00000521429 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-5UTR | ENST00000436581 | ENST00000517476 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-5UTR | ENST00000436581 | ENST00000521429 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-5UTR | ENST00000518844 | ENST00000517476 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-5UTR | ENST00000518844 | ENST00000521429 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-5UTR | ENST00000520724 | ENST00000517476 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-5UTR | ENST00000520724 | ENST00000521429 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-5UTR | ENST00000521553 | ENST00000517476 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-5UTR | ENST00000521553 | ENST00000521429 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-5UTR | ENST00000522163 | ENST00000517476 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
intron-5UTR | ENST00000522163 | ENST00000521429 | RUNX1T1 | chr8 | 93115085 | - | E2F5 | chr8 | 86114382 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for RUNX1T1-E2F5 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
RUNX1T1 | chr8 | 93115084 | - | E2F5 | chr8 | 86114381 | + | 0.005792223 | 0.99420774 |
RUNX1T1 | chr8 | 93115084 | - | E2F5 | chr8 | 86114381 | + | 0.005792223 | 0.99420774 |
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Fusion Protein Features for RUNX1T1-E2F5 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:93115085/:86114382) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
RUNX1T1 | E2F5 |
FUNCTION: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199, PubMed:10688654). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588). {ECO:0000250|UniProtKB:Q61909, ECO:0000269|PubMed:10688654, ECO:0000269|PubMed:10973986, ECO:0000269|PubMed:16803958, ECO:0000269|PubMed:23251453, ECO:0000269|PubMed:23812588, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}. | FUNCTION: Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. {ECO:0000250|UniProtKB:Q6DE14}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for RUNX1T1-E2F5 |
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Fusion Gene PPI Analysis for RUNX1T1-E2F5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for RUNX1T1-E2F5 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for RUNX1T1-E2F5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | RUNX1T1 | C0023467 | Leukemia, Myelocytic, Acute | 2 | CTD_human |
Hgene | RUNX1T1 | C0026998 | Acute Myeloid Leukemia, M1 | 2 | CTD_human |
Hgene | RUNX1T1 | C1879321 | Acute Myeloid Leukemia (AML-M2) | 2 | CTD_human |
Hgene | RUNX1T1 | C0149925 | Small cell carcinoma of lung | 1 | CTD_human |
Tgene | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human | |
Tgene | C0235874 | Disease Exacerbation | 1 | CTD_human |