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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EIF3A-PSME1 (FusionGDB2 ID:HG8661TG5720)

Fusion Gene Summary for EIF3A-PSME1

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF3A-PSME1
Fusion gene ID: hg8661tg5720
HgeneTgene
Gene symbol

EIF3A

PSME1

Gene ID

8661

5720

Gene nameeukaryotic translation initiation factor 3 subunit Aproteasome activator subunit 1
SynonymsEIF3|EIF3S10|P167|TIF32|eIF3-p170|eIF3-theta|p180|p185HEL-S-129m|IFI5111|PA28A|PA28alpha|REGalpha
Cytomap('EIF3A')('PSME1')

10q26.11

14q12

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic translation initiation factor 3 subunit AEIF3, p180 subunitcentrosomin homologcytoplasmic protein p167eIF-3-thetaeIF3 p167eIF3 p180eIF3 p185eukaryotic translation initiation factor 3 subunit 10eukaryotic translation initiation factor 3proteasome activator complex subunit 111S regulator complex subunit alpha29-kD MCP activator subunitIGUP I-5111activator of multicatalytic protease subunit 1epididymis secretory sperm binding protein Li 129minterferon gamma up-regulated I-5111 prote
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000369144, ENST00000541549, 
Fusion gene scores* DoF score16 X 18 X 6=17287 X 6 X 3=126
# samples 197
** MAII scorelog2(19/1728*10)=-3.18503189383252
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EIF3A [Title/Abstract] AND PSME1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEIF3A(120810032)-PSME1(24606529), # samples:1
Anticipated loss of major functional domain due to fusion event.EIF3A-PSME1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EIF3A-PSME1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EIF3A-PSME1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EIF3A-PSME1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EIF3A-PSME1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
EIF3A-PSME1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
EIF3A-PSME1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEIF3A

GO:0001732

formation of cytoplasmic translation initiation complex

17581632

HgeneEIF3A

GO:0075522

IRES-dependent viral translational initiation

9573242|23766293|24357634

HgeneEIF3A

GO:0075525

viral translational termination-reinitiation

21347434


check buttonFusion gene breakpoints across EIF3A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PSME1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-IG-A3YAEIF3Achr10

120810032

-PSME1chr14

24606529

+


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Fusion Gene ORF analysis for EIF3A-PSME1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000369144ENST00000470718EIF3Achr10

120810032

-PSME1chr14

24606529

+
5CDS-3UTRENST00000541549ENST00000470718EIF3Achr10

120810032

-PSME1chr14

24606529

+
5CDS-5UTRENST00000369144ENST00000382708EIF3Achr10

120810032

-PSME1chr14

24606529

+
5CDS-5UTRENST00000369144ENST00000559123EIF3Achr10

120810032

-PSME1chr14

24606529

+
5CDS-5UTRENST00000369144ENST00000561435EIF3Achr10

120810032

-PSME1chr14

24606529

+
5CDS-5UTRENST00000541549ENST00000382708EIF3Achr10

120810032

-PSME1chr14

24606529

+
5CDS-5UTRENST00000541549ENST00000559123EIF3Achr10

120810032

-PSME1chr14

24606529

+
5CDS-5UTRENST00000541549ENST00000561435EIF3Achr10

120810032

-PSME1chr14

24606529

+
Frame-shiftENST00000369144ENST00000206451EIF3Achr10

120810032

-PSME1chr14

24606529

+
In-frameENST00000541549ENST00000206451EIF3Achr10

120810032

-PSME1chr14

24606529

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000541549EIF3Achr10120810032-ENST00000206451PSME1chr1424606529+33302564132580855

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000541549ENST00000206451EIF3Achr10120810032-PSME1chr1424606529+0.0038258630.99617416

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Fusion Genomic Features for EIF3A-PSME1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EIF3Achr10120810032-PSME1chr1424606529+0.003870720.9961293
EIF3Achr10120810032-PSME1chr1424606529+0.003870720.9961293

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for EIF3A-PSME1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:120810032/chr14:24606529)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEIF3Achr10:120810032chr14:24606529ENST00000369144-162282_1208241383.0Coiled coilOntology_term=ECO:0000255
HgeneEIF3Achr10:120810032chr14:24606529ENST00000369144-1622315_4988241383.0DomainPCI

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEIF3Achr10:120810032chr14:24606529ENST00000369144-1622576_8758241383.0Compositional biasNote=Glu-rich
HgeneEIF3Achr10:120810032chr14:24606529ENST00000369144-1622925_12948241383.0Compositional biasNote=Asp-rich
HgeneEIF3Achr10:120810032chr14:24606529ENST00000369144-1622925_11728241383.0RegionNote=25 X 10 AA approximate tandem repeats of [DE]-[DE]-[DE]-R-[SEVGFPILV]-[HPSN]-[RSW]-[RL]-[DRGTIHN]-[EPMANLGDT]
HgeneEIF3Achr10:120810032chr14:24606529ENST00000369144-16221003_10128241383.0RepeatNote=9
HgeneEIF3Achr10:120810032chr14:24606529ENST00000369144-16221013_10228241383.0RepeatNote=10
HgeneEIF3Achr10:120810032chr14:24606529ENST00000369144-16221023_10328241383.0RepeatNote=11
HgeneEIF3Achr10:120810032chr14:24606529ENST00000369144-16221033_10428241383.0RepeatNote=12
HgeneEIF3Achr10:120810032chr14:24606529ENST00000369144-16221043_10528241383.0RepeatNote=13
HgeneEIF3Achr10:120810032chr14:24606529ENST00000369144-16221054_10638241383.0RepeatNote=14
HgeneEIF3Achr10:120810032chr14:24606529ENST00000369144-16221064_10738241383.0RepeatNote=15
HgeneEIF3Achr10:120810032chr14:24606529ENST00000369144-16221074_10838241383.0RepeatNote=16
HgeneEIF3Achr10:120810032chr14:24606529ENST00000369144-16221084_10938241383.0RepeatNote=17
HgeneEIF3Achr10:120810032chr14:24606529ENST00000369144-16221094_11038241383.0RepeatNote=18
HgeneEIF3Achr10:120810032chr14:24606529ENST00000369144-16221104_11138241383.0RepeatNote=19
HgeneEIF3Achr10:120810032chr14:24606529ENST00000369144-16221114_11238241383.0RepeatNote=20
HgeneEIF3Achr10:120810032chr14:24606529ENST00000369144-16221124_11338241383.0RepeatNote=21
HgeneEIF3Achr10:120810032chr14:24606529ENST00000369144-16221134_11438241383.0RepeatNote=22
HgeneEIF3Achr10:120810032chr14:24606529ENST00000369144-16221144_11528241383.0RepeatNote=23%3B truncated
HgeneEIF3Achr10:120810032chr14:24606529ENST00000369144-16221153_11628241383.0RepeatNote=24
HgeneEIF3Achr10:120810032chr14:24606529ENST00000369144-16221163_11728241383.0RepeatNote=25%3B approximate
HgeneEIF3Achr10:120810032chr14:24606529ENST00000369144-1622925_9348241383.0RepeatNote=1
HgeneEIF3Achr10:120810032chr14:24606529ENST00000369144-1622935_9428241383.0RepeatNote=2%3B truncated
HgeneEIF3Achr10:120810032chr14:24606529ENST00000369144-1622943_9528241383.0RepeatNote=3
HgeneEIF3Achr10:120810032chr14:24606529ENST00000369144-1622953_9628241383.0RepeatNote=4
HgeneEIF3Achr10:120810032chr14:24606529ENST00000369144-1622963_9728241383.0RepeatNote=5
HgeneEIF3Achr10:120810032chr14:24606529ENST00000369144-1622973_9828241383.0RepeatNote=6
HgeneEIF3Achr10:120810032chr14:24606529ENST00000369144-1622983_9928241383.0RepeatNote=7
HgeneEIF3Achr10:120810032chr14:24606529ENST00000369144-1622993_10028241383.0RepeatNote=8


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Fusion Gene Sequence for EIF3A-PSME1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>25767_25767_1_EIF3A-PSME1_EIF3A_chr10_120810032_ENST00000541549_PSME1_chr14_24606529_ENST00000206451_length(transcript)=3330nt_BP=2564nt
AGACCGATGCGGCCTGCCCGCCGCTGTCCCAGCCGGTGGTTGGGCATGGGTTTCCTTCTCACTCTATCGACTGGGGTCTGGGAGGCGCGT
AGCCCGGAACCGTCGCCCCAGGGGCCTTTCCTTCCCCCTGCCGCCTCCGGAATTTCTTGAGGTTGGCAAAAAGCAGCCTGCTCTGGATGT
TCTTTATGATGTTATGAAAAGTAAAAAACATAGAACATGGCAAAAGATACACGAACCAATTATGTTGAAATACTTGGAACTTTGCGTGGA
TCTTCGCAAGAGCCACTTGGCAAAGGAGGGGTTATACCAGTATAAGAACATTTGTCAACAGGTGAACATAAAATCTCTGGAGGATGTTGT
TAGGGCATATTTGAAAATGGCAGAGGAAAAAACTGAAGCTGCTAAAGAAGAATCTCAGCAGATGGTCTTAGATATAGAGGATCTAGATAA
TATTCAAACTCCTGAGAGTGTTCTCCTAAGTGCTGTAAGTGGTGAAGACACTCAGGATCGTACTGACAGATTACTTTTAACTCCATGGGT
TAAATTCCTGTGGGAGTCTTACAGGCAGTGTTTGGACCTTCTTAGAAACAATTCTAGAGTAGAGCGCCTGTACCATGATATTGCCCAGCA
AGCTTTCAAATTCTGCCTCCAATACACGCGTAAGGCTGAATTCCGTAAACTGTGTGACAATTTGAGAATGCACTTATCGCAGATTCAGCG
CCACCATAACCAAAGTACGGCAATCAATCTTAATAATCCAGAGAGCCAGTCCATGCATTTGGAAACCAGACTTGTTCAGCTGGACAGTGC
TATCAGCATGGAATTGTGGCAGGAAGCATTCAAAGCTGTGGAAGATATTCACGGGCTATTCTCCTTGTCTAAAAAACCACCTAAACCTCA
GTTGATGGCAAATTACTATAACAAAGTCTCAACTGTGTTTTGGAAATCTGGAAATGCTCTTTTTCATGCATCTACACTCCATCGTCTTTA
CCATCTCTCTAGAGAAATGAGAAAGAATCTCACACAAGATGAGATGCAAAGAATGTCTACTAGAGTCCTTTTAGCCACTCTTTCCATCCC
TATTACTCCTGAGCGTACGGATATTGCTCGACTTCTGGATATGGATGGCATTATAGTTGAAAAACAGCGTCGCCTTGCAACACTACTAGG
TCTTCAAGCCCCACCGACACGAATTGGCCTTATTAATGATATGGTCAGATTTAATGTACTACAATATGTTGTCCCAGAAGTGAAAGACCT
TTACAATTGGCTTGAAGTAGAATTTAACCCATTAAAACTCTGTGAGCGAGTCACAAAGGTTCTAAATTGGGTTAGGGAACAACCTGAAAA
GGAACCGGAATTGCAGCAGTATGTGCCACAACTGCAAAACAACACCATCCTCCGCCTTCTGCAGCAGGTGTCACAGATTTATCAGAGCAT
TGAGTTTTCTCGTTTGACTTCTTTGGTTCCTTTTGTTGATGCTTTCCAACTGGAACGGGCCATAGTAGATGCAGCCAGGCATTGCGACTT
GCAGGTTCGTATTGATCACACTTCTCGGACCCTGAGTTTTGGATCTGATTTGAATTATGCTACTCGAGAAGATGCTCCGATTGGTCCTCA
TTTGCAAAGCATGCCTTCAGAGCAGATAAGAAACCAGCTGACAGCCATGTCCTCAGTACTTGCAAAAGCACTTGAAGTCATTAAACCAGC
TCATATACTGCAAGAGAAAGAAGAACAGCATCAGTTGGCTGTCACTGCATACCTTAAAAATTCACGAAAAGAGCACCAGCGGATCCTGGC
TCGCCGCCAGACAATTGAGGAGAGAAAAGAGCGCCTTGAGAGTCTGAATATTCAGCGTGAGAAAGAAGAATTGGAACAGAGGGAAGCTGA
ACTCCAGAAAGTGCGGAAGGCTGAGGAAGAGAGGCTGCGCCAGGAAGCAAAGGAGAGAGAGAAGGAGCGTATCTTACAGGAACATGAACA
AATCAAAAAGAAAACTGTCCGAGAGCGTTTGGAGCAGATCAAGAAAACAGAACTGGGTGCCAAAGCATTCAAAGATATTGATATTGAAGA
CCTTGAGGAATTGGATCCAGATTTTATCATGGCTAAACAGGTTGAACAACTGGAGAAAGAAAAGAAAGAACTTCAAGAACGCCTAAAGAA
TCAAGAAAAGAAGATTGACTATTTTGAAAGAGCCAAACGTTTGGAAGAAATTCCTTTGATAAAGAGCGCTTACGAGGAACAGAGAATTAA
AGACATGGATCTGTGGGAGCAACAAGAGGAAGAAAGAATTACTACAATGCAGCTAGAACGTGAAAAGGCTCTTGAACATAAGAATCGAAT
GTCACGAATGCTTGAAGACAGAGATTTATTCGTAATGCGACTCAAAGCTGCACGGCAGTCTGTTTATGAGGAAAAACTTAAACAGTTTGA
AGAGCGATTAGCAGAAGAAAGGCATAATCGATTGGAAGAACGGAAAAGGCAGCGTAAAGAAGAACGCAGGATAACATACTATAGAGAAAA
AGAAGAGGAGGAGCAGAGAAGGGCAGAAGAACAAATGCTAAAAGGAGCCAGCTCTCAATGAAGCCAACTTGAGCAATCTGAAGGCCCCAT
TGGACATCCCAGTGCCTGATCCAGTCAAGGAGAAAGAGAAAGAGGAGCGGAAGAAACAGCAGGAGAAGGAAGACAAGGATGAAAAGAAGA
AGGGGGAGGATGAAGACAAAGGTCCTCCCTGTGGCCCAGTGAACTGCAATGAAAAGATCGTGGTCCTTCTGCAGCGCTTGAAGCCTGAGA
TCAAGGATGTCATTGAGCAGCTCAACCTGGTCACCACCTGGTTGCAGCTGCAGATACCTCGGATTGAGGATGGTAACAATTTTGGAGTGG
CTGTCCAGGAGAAGGTGTTTGAGCTGATGACCAGCCTCCACACCAAGCTAGAAGGCTTCCACACTCAAATCTCTAAGTATTTCTCTGAGC
GTGGTGATGCAGTGACTAAAGCAGCCAAGCAGCCCCATGTGGGTGATTATCGGCAGCTGGTGCACGAGCTGGATGAGGCAGAGTACCGGG
ACATCCGGCTGATGGTCATGGAGATCCGCAATGCTTATGCTGTGTTATATGACATCATCCTGAAGAACTTCGAGAAGCTCAAGAAGCCCA
GGGGAGAAACAAAGGGAATGATCTATTGAGAGCCCTCTCTCCCATTCTGTGATGAGTACAGCAGAGACCTTCCTGCTTTTTACTGGGGAC
TCCAGATTTTCCCCAAACTTGCTTCTGTTGAGATTTTTCCCTCACCTTGCCTCTCAGGCACAATAAATATAGTTATACCACTGCCCATCA

>25767_25767_1_EIF3A-PSME1_EIF3A_chr10_120810032_ENST00000541549_PSME1_chr14_24606529_ENST00000206451_length(amino acids)=855AA_BP=
MPAAVPAGGWAWVSFSLYRLGSGRRVARNRRPRGLSFPLPPPEFLEVGKKQPALDVLYDVMKSKKHRTWQKIHEPIMLKYLELCVDLRKS
HLAKEGLYQYKNICQQVNIKSLEDVVRAYLKMAEEKTEAAKEESQQMVLDIEDLDNIQTPESVLLSAVSGEDTQDRTDRLLLTPWVKFLW
ESYRQCLDLLRNNSRVERLYHDIAQQAFKFCLQYTRKAEFRKLCDNLRMHLSQIQRHHNQSTAINLNNPESQSMHLETRLVQLDSAISME
LWQEAFKAVEDIHGLFSLSKKPPKPQLMANYYNKVSTVFWKSGNALFHASTLHRLYHLSREMRKNLTQDEMQRMSTRVLLATLSIPITPE
RTDIARLLDMDGIIVEKQRRLATLLGLQAPPTRIGLINDMVRFNVLQYVVPEVKDLYNWLEVEFNPLKLCERVTKVLNWVREQPEKEPEL
QQYVPQLQNNTILRLLQQVSQIYQSIEFSRLTSLVPFVDAFQLERAIVDAARHCDLQVRIDHTSRTLSFGSDLNYATREDAPIGPHLQSM
PSEQIRNQLTAMSSVLAKALEVIKPAHILQEKEEQHQLAVTAYLKNSRKEHQRILARRQTIEERKERLESLNIQREKEELEQREAELQKV
RKAEEERLRQEAKEREKERILQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIEDLEELDPDFIMAKQVEQLEKEKKELQERLKNQEKK
IDYFERAKRLEEIPLIKSAYEEQRIKDMDLWEQQEEERITTMQLEREKALEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFEERLA

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Fusion Gene PPI Analysis for EIF3A-PSME1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneEIF3Achr10:120810032chr14:24606529ENST00000369144-1622664_835824.33333333333341383.0EIF3B


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EIF3A-PSME1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EIF3A-PSME1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEIF3AC0033578Prostatic Neoplasms1CTD_human
HgeneEIF3AC0376358Malignant neoplasm of prostate1CTD_human
TgeneC0007097Carcinoma1CTD_human
TgeneC0019693HIV Infections1CTD_human
TgeneC0024667Animal Mammary Neoplasms1CTD_human
TgeneC0024668Mammary Neoplasms, Experimental1CTD_human
TgeneC0205696Anaplastic carcinoma1CTD_human
TgeneC0205697Carcinoma, Spindle-Cell1CTD_human
TgeneC0205698Undifferentiated carcinoma1CTD_human
TgeneC0205699Carcinomatosis1CTD_human
TgeneC0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneC1257925Mammary Carcinoma, Animal1CTD_human
TgeneC4505456HIV Coinfection1CTD_human