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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:EIF4G3-HP1BP3 (FusionGDB2 ID:HG8672TG50809)

Fusion Gene Summary for EIF4G3-HP1BP3

Fusion gene summary

Fusion gene information	Fusion gene name: EIF4G3-HP1BP3
	Fusion gene ID: hg8672tg50809
		Hgene	Tgene
	Gene symbol	EIF4G3	HP1BP3
	Gene ID	8672	50809
	Gene name	eukaryotic translation initiation factor 4 gamma 3	heterochromatin protein 1 binding protein 3
	Synonyms	eIF-4G 3\|eIF4G 3\|eIF4GII	HP1-BP74\|HP1BP74
	Cytomap	('EIF4G3')('HP1BP3') 1p36.12	1p36.12
	Type of gene	protein-coding	protein-coding
	Description	eukaryotic translation initiation factor 4 gamma 3eIF-4-gamma 3eIF-4-gamma II	heterochromatin protein 1-binding protein 3
	Modification date	20200313	20200313
	UniProtAcc	O43432	Q5SSJ5
	Ensembl transtripts involved in fusion gene	ENST00000356916, ENST00000374927, ENST00000400422, ENST00000602326, ENST00000264211, ENST00000374933, ENST00000374935, ENST00000374937, ENST00000536266, ENST00000537738, ENST00000544689,	ENST00000356916, ENST00000374927, ENST00000374933, ENST00000537738, ENST00000544689, ENST00000264211, ENST00000374935, ENST00000374937, ENST00000400422, ENST00000536266, ENST00000602326,
Fusion gene scores	* DoF score	22 X 20 X 11=4840	22 X 14 X 10=3080
	# samples	32	24
	** MAII score	log2(32/4840*10)=-3.91886323727459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(24/3080*10)=-3.68182403997374 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: EIF4G3 [Title/Abstract] AND HP1BP3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	EIF4G3(21415630)-HP1BP3(21083749), # samples:1 EIF4G3(21503215)-HP1BP3(21074148), # samples:1 EIF4G3(21415631)-HP1BP3(21083749), # samples:1 EIF4G3(21415631)-HP1BP3(21076375), # samples:1
Anticipated loss of major functional domain due to fusion event.	HP1BP3-EIF4G3 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. HP1BP3-EIF4G3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. HP1BP3-EIF4G3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	HP1BP3	GO:0071456	cellular response to hypoxia	25100860

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-E2-A1LL-01A	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
ChimerDB4	STAD	TCGA-CD-8525-01A	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
ChimerDB4	STAD	TCGA-CD-8525-01A	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
ChimerDB4	STAD	TCGA-CD-8525	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-

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Fusion Gene ORF analysis for EIF4G3-HP1BP3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000356916	ENST00000312239	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
5UTR-3CDS	ENST00000356916	ENST00000312239	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
5UTR-3CDS	ENST00000356916	ENST00000312239	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
5UTR-3CDS	ENST00000374927	ENST00000312239	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
5UTR-3CDS	ENST00000374927	ENST00000312239	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
5UTR-3CDS	ENST00000374927	ENST00000312239	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
5UTR-3CDS	ENST00000400422	ENST00000312239	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
5UTR-3CDS	ENST00000400422	ENST00000312239	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
5UTR-3CDS	ENST00000400422	ENST00000312239	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
5UTR-3CDS	ENST00000400422	ENST00000312239	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
5UTR-3CDS	ENST00000602326	ENST00000312239	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
5UTR-3CDS	ENST00000602326	ENST00000312239	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
5UTR-3CDS	ENST00000602326	ENST00000312239	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
5UTR-3CDS	ENST00000602326	ENST00000312239	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
5UTR-intron	ENST00000356916	ENST00000375000	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
5UTR-intron	ENST00000356916	ENST00000375000	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
5UTR-intron	ENST00000356916	ENST00000375000	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
5UTR-intron	ENST00000356916	ENST00000375003	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
5UTR-intron	ENST00000356916	ENST00000375003	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
5UTR-intron	ENST00000356916	ENST00000375003	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
5UTR-intron	ENST00000356916	ENST00000487117	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
5UTR-intron	ENST00000356916	ENST00000487117	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
5UTR-intron	ENST00000356916	ENST00000487117	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
5UTR-intron	ENST00000374927	ENST00000375000	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
5UTR-intron	ENST00000374927	ENST00000375000	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
5UTR-intron	ENST00000374927	ENST00000375000	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
5UTR-intron	ENST00000374927	ENST00000375003	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
5UTR-intron	ENST00000374927	ENST00000375003	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
5UTR-intron	ENST00000374927	ENST00000375003	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
5UTR-intron	ENST00000374927	ENST00000487117	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
5UTR-intron	ENST00000374927	ENST00000487117	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
5UTR-intron	ENST00000374927	ENST00000487117	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
5UTR-intron	ENST00000400422	ENST00000375000	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
5UTR-intron	ENST00000400422	ENST00000375000	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
5UTR-intron	ENST00000400422	ENST00000375000	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
5UTR-intron	ENST00000400422	ENST00000375000	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
5UTR-intron	ENST00000400422	ENST00000375003	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
5UTR-intron	ENST00000400422	ENST00000375003	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
5UTR-intron	ENST00000400422	ENST00000375003	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
5UTR-intron	ENST00000400422	ENST00000375003	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
5UTR-intron	ENST00000400422	ENST00000487117	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
5UTR-intron	ENST00000400422	ENST00000487117	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
5UTR-intron	ENST00000400422	ENST00000487117	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
5UTR-intron	ENST00000400422	ENST00000487117	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
5UTR-intron	ENST00000602326	ENST00000375000	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
5UTR-intron	ENST00000602326	ENST00000375000	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
5UTR-intron	ENST00000602326	ENST00000375000	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
5UTR-intron	ENST00000602326	ENST00000375000	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
5UTR-intron	ENST00000602326	ENST00000375003	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
5UTR-intron	ENST00000602326	ENST00000375003	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
5UTR-intron	ENST00000602326	ENST00000375003	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
5UTR-intron	ENST00000602326	ENST00000375003	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
5UTR-intron	ENST00000602326	ENST00000487117	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
5UTR-intron	ENST00000602326	ENST00000487117	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
5UTR-intron	ENST00000602326	ENST00000487117	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
5UTR-intron	ENST00000602326	ENST00000487117	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
intron-3CDS	ENST00000264211	ENST00000312239	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-3CDS	ENST00000264211	ENST00000312239	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
intron-3CDS	ENST00000264211	ENST00000312239	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
intron-3CDS	ENST00000264211	ENST00000312239	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
intron-3CDS	ENST00000356916	ENST00000312239	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-3CDS	ENST00000374927	ENST00000312239	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-3CDS	ENST00000374933	ENST00000312239	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-3CDS	ENST00000374933	ENST00000312239	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
intron-3CDS	ENST00000374933	ENST00000312239	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
intron-3CDS	ENST00000374933	ENST00000312239	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
intron-3CDS	ENST00000374935	ENST00000312239	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-3CDS	ENST00000374935	ENST00000312239	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
intron-3CDS	ENST00000374935	ENST00000312239	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
intron-3CDS	ENST00000374935	ENST00000312239	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
intron-3CDS	ENST00000374937	ENST00000312239	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-3CDS	ENST00000374937	ENST00000312239	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
intron-3CDS	ENST00000374937	ENST00000312239	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
intron-3CDS	ENST00000374937	ENST00000312239	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
intron-3CDS	ENST00000536266	ENST00000312239	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-3CDS	ENST00000536266	ENST00000312239	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
intron-3CDS	ENST00000536266	ENST00000312239	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
intron-3CDS	ENST00000536266	ENST00000312239	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
intron-3CDS	ENST00000537738	ENST00000312239	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-3CDS	ENST00000537738	ENST00000312239	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
intron-3CDS	ENST00000537738	ENST00000312239	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
intron-3CDS	ENST00000537738	ENST00000312239	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
intron-3CDS	ENST00000544689	ENST00000312239	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-3CDS	ENST00000544689	ENST00000312239	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
intron-3CDS	ENST00000544689	ENST00000312239	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
intron-3CDS	ENST00000544689	ENST00000312239	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000264211	ENST00000375000	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-intron	ENST00000264211	ENST00000375000	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
intron-intron	ENST00000264211	ENST00000375000	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000264211	ENST00000375000	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000264211	ENST00000375003	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-intron	ENST00000264211	ENST00000375003	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
intron-intron	ENST00000264211	ENST00000375003	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000264211	ENST00000375003	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000264211	ENST00000487117	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-intron	ENST00000264211	ENST00000487117	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
intron-intron	ENST00000264211	ENST00000487117	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000264211	ENST00000487117	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000356916	ENST00000375000	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-intron	ENST00000356916	ENST00000375003	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-intron	ENST00000356916	ENST00000487117	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-intron	ENST00000374927	ENST00000375000	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-intron	ENST00000374927	ENST00000375003	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-intron	ENST00000374927	ENST00000487117	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-intron	ENST00000374933	ENST00000375000	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-intron	ENST00000374933	ENST00000375000	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
intron-intron	ENST00000374933	ENST00000375000	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000374933	ENST00000375000	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000374933	ENST00000375003	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-intron	ENST00000374933	ENST00000375003	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
intron-intron	ENST00000374933	ENST00000375003	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000374933	ENST00000375003	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000374933	ENST00000487117	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-intron	ENST00000374933	ENST00000487117	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
intron-intron	ENST00000374933	ENST00000487117	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000374933	ENST00000487117	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000374935	ENST00000375000	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-intron	ENST00000374935	ENST00000375000	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
intron-intron	ENST00000374935	ENST00000375000	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000374935	ENST00000375000	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000374935	ENST00000375003	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-intron	ENST00000374935	ENST00000375003	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
intron-intron	ENST00000374935	ENST00000375003	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000374935	ENST00000375003	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000374935	ENST00000487117	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-intron	ENST00000374935	ENST00000487117	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
intron-intron	ENST00000374935	ENST00000487117	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000374935	ENST00000487117	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000374937	ENST00000375000	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-intron	ENST00000374937	ENST00000375000	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
intron-intron	ENST00000374937	ENST00000375000	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000374937	ENST00000375000	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000374937	ENST00000375003	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-intron	ENST00000374937	ENST00000375003	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
intron-intron	ENST00000374937	ENST00000375003	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000374937	ENST00000375003	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000374937	ENST00000487117	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-intron	ENST00000374937	ENST00000487117	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
intron-intron	ENST00000374937	ENST00000487117	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000374937	ENST00000487117	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000536266	ENST00000375000	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-intron	ENST00000536266	ENST00000375000	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
intron-intron	ENST00000536266	ENST00000375000	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000536266	ENST00000375000	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000536266	ENST00000375003	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-intron	ENST00000536266	ENST00000375003	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
intron-intron	ENST00000536266	ENST00000375003	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000536266	ENST00000375003	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000536266	ENST00000487117	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-intron	ENST00000536266	ENST00000487117	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
intron-intron	ENST00000536266	ENST00000487117	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000536266	ENST00000487117	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000537738	ENST00000375000	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-intron	ENST00000537738	ENST00000375000	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
intron-intron	ENST00000537738	ENST00000375000	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000537738	ENST00000375000	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000537738	ENST00000375003	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-intron	ENST00000537738	ENST00000375003	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
intron-intron	ENST00000537738	ENST00000375003	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000537738	ENST00000375003	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000537738	ENST00000487117	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-intron	ENST00000537738	ENST00000487117	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
intron-intron	ENST00000537738	ENST00000487117	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000537738	ENST00000487117	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000544689	ENST00000375000	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-intron	ENST00000544689	ENST00000375000	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
intron-intron	ENST00000544689	ENST00000375000	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000544689	ENST00000375000	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000544689	ENST00000375003	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-intron	ENST00000544689	ENST00000375003	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
intron-intron	ENST00000544689	ENST00000375003	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000544689	ENST00000375003	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000544689	ENST00000487117	EIF4G3	chr1	21503215	-	HP1BP3	chr1	21074148	-
intron-intron	ENST00000544689	ENST00000487117	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21076375	-
intron-intron	ENST00000544689	ENST00000487117	EIF4G3	chr1	21415631	-	HP1BP3	chr1	21083749	-
intron-intron	ENST00000544689	ENST00000487117	EIF4G3	chr1	21415630	-	HP1BP3	chr1	21083749	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for EIF4G3-HP1BP3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

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Fusion Protein Features for EIF4G3-HP1BP3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:21415630/:21083749)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EIF4G3 O43432	HP1BP3 Q5SSJ5
FUNCTION: Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1. {ECO:0000269\|PubMed:9418880}.	FUNCTION: Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal(PubMed:25100860). {ECO:0000269\|PubMed:24830416, ECO:0000269\|PubMed:25100860}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for EIF4G3-HP1BP3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for EIF4G3-HP1BP3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for EIF4G3-HP1BP3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for EIF4G3-HP1BP3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene		C0221074	Depression, Postpartum	1	PSYGENET

Fusion Gene Studies in Kim Lab

Fusion gene:EIF4G3-HP1BP3 (FusionGDB2 ID:HG8672TG50809)

Fusion Gene Summary for EIF4G3-HP1BP3

Fusion Gene ORF analysis for EIF4G3-HP1BP3

Fusion Genomic Features for EIF4G3-HP1BP3

Fusion Protein Features for EIF4G3-HP1BP3

Fusion Gene Sequence for EIF4G3-HP1BP3

Fusion Gene PPI Analysis for EIF4G3-HP1BP3

Related Drugs for EIF4G3-HP1BP3

Related Diseases for EIF4G3-HP1BP3

Fusion Gene Studies
in Kim Lab