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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:EIF4G3-CDC42 (FusionGDB2 ID:HG8672TG998) |
Fusion Gene Summary for EIF4G3-CDC42 |
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Fusion gene information | Fusion gene name: EIF4G3-CDC42 | Fusion gene ID: hg8672tg998 | Hgene | Tgene | Gene symbol | EIF4G3 | CDC42 | Gene ID | 8672 | 998 |
Gene name | eukaryotic translation initiation factor 4 gamma 3 | cell division cycle 42 | |
Synonyms | eIF-4G 3|eIF4G 3|eIF4GII | CDC42Hs|G25K|TKS | |
Cytomap | ('EIF4G3')('CDC42') 1p36.12 | 1p36.12 | |
Type of gene | protein-coding | protein-coding | |
Description | eukaryotic translation initiation factor 4 gamma 3eIF-4-gamma 3eIF-4-gamma II | cell division control protein 42 homologG25K GTP-binding proteinGTP binding protein, 25kDadJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD))dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD))growth-regulating proteinsmall | |
Modification date | 20200313 | 20200327 | |
UniProtAcc | O43432 | P60953 | |
Ensembl transtripts involved in fusion gene | ENST00000264211, ENST00000356916, ENST00000374927, ENST00000374935, ENST00000374937, ENST00000400422, ENST00000602326, ENST00000374933, ENST00000536266, ENST00000537738, ENST00000544689, | ||
Fusion gene scores | * DoF score | 22 X 20 X 11=4840 | 12 X 6 X 7=504 |
# samples | 32 | 12 | |
** MAII score | log2(32/4840*10)=-3.91886323727459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/504*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: EIF4G3 [Title/Abstract] AND CDC42 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | EIF4G3(21377359)-CDC42(22404922), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CDC42 | GO:0030036 | actin cytoskeleton organization | 11035016 |
Tgene | CDC42 | GO:0031274 | positive regulation of pseudopodium assembly | 11035016 |
Tgene | CDC42 | GO:0051489 | regulation of filopodium assembly | 14978216 |
Tgene | CDC42 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading | 11807099 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-HU-A4HB-01A | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
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Fusion Gene ORF analysis for EIF4G3-CDC42 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3UTR | ENST00000264211 | ENST00000498236 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-3UTR | ENST00000356916 | ENST00000498236 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-3UTR | ENST00000374927 | ENST00000498236 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-3UTR | ENST00000374935 | ENST00000498236 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-3UTR | ENST00000374937 | ENST00000498236 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-3UTR | ENST00000400422 | ENST00000498236 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-3UTR | ENST00000602326 | ENST00000498236 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-5UTR | ENST00000264211 | ENST00000315554 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-5UTR | ENST00000264211 | ENST00000344548 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-5UTR | ENST00000264211 | ENST00000400259 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-5UTR | ENST00000264211 | ENST00000421089 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-5UTR | ENST00000356916 | ENST00000315554 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-5UTR | ENST00000356916 | ENST00000344548 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-5UTR | ENST00000356916 | ENST00000400259 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-5UTR | ENST00000356916 | ENST00000421089 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-5UTR | ENST00000374927 | ENST00000315554 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-5UTR | ENST00000374927 | ENST00000344548 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-5UTR | ENST00000374927 | ENST00000400259 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-5UTR | ENST00000374927 | ENST00000421089 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-5UTR | ENST00000374935 | ENST00000315554 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-5UTR | ENST00000374935 | ENST00000344548 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-5UTR | ENST00000374935 | ENST00000400259 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-5UTR | ENST00000374935 | ENST00000421089 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-5UTR | ENST00000374937 | ENST00000315554 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-5UTR | ENST00000374937 | ENST00000344548 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-5UTR | ENST00000374937 | ENST00000400259 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-5UTR | ENST00000374937 | ENST00000421089 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-5UTR | ENST00000400422 | ENST00000315554 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-5UTR | ENST00000400422 | ENST00000344548 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-5UTR | ENST00000400422 | ENST00000400259 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-5UTR | ENST00000400422 | ENST00000421089 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-5UTR | ENST00000602326 | ENST00000315554 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-5UTR | ENST00000602326 | ENST00000344548 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-5UTR | ENST00000602326 | ENST00000400259 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
5UTR-5UTR | ENST00000602326 | ENST00000421089 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
intron-3UTR | ENST00000374933 | ENST00000498236 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
intron-3UTR | ENST00000536266 | ENST00000498236 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
intron-3UTR | ENST00000537738 | ENST00000498236 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
intron-3UTR | ENST00000544689 | ENST00000498236 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
intron-5UTR | ENST00000374933 | ENST00000315554 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
intron-5UTR | ENST00000374933 | ENST00000344548 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
intron-5UTR | ENST00000374933 | ENST00000400259 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
intron-5UTR | ENST00000374933 | ENST00000421089 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
intron-5UTR | ENST00000536266 | ENST00000315554 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
intron-5UTR | ENST00000536266 | ENST00000344548 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
intron-5UTR | ENST00000536266 | ENST00000400259 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
intron-5UTR | ENST00000536266 | ENST00000421089 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
intron-5UTR | ENST00000537738 | ENST00000315554 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
intron-5UTR | ENST00000537738 | ENST00000344548 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
intron-5UTR | ENST00000537738 | ENST00000400259 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
intron-5UTR | ENST00000537738 | ENST00000421089 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
intron-5UTR | ENST00000544689 | ENST00000315554 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
intron-5UTR | ENST00000544689 | ENST00000344548 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
intron-5UTR | ENST00000544689 | ENST00000400259 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
intron-5UTR | ENST00000544689 | ENST00000421089 | EIF4G3 | chr1 | 21377359 | - | CDC42 | chr1 | 22404922 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for EIF4G3-CDC42 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
EIF4G3 | chr1 | 21377358 | - | CDC42 | chr1 | 22404921 | + | 1.69E-05 | 0.9999831 |
EIF4G3 | chr1 | 21377358 | - | CDC42 | chr1 | 22404921 | + | 1.69E-05 | 0.9999831 |
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Fusion Protein Features for EIF4G3-CDC42 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:21377359/:22404922) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
EIF4G3 | CDC42 |
FUNCTION: Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1. {ECO:0000269|PubMed:9418880}. | FUNCTION: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase (PubMed:15642749). Regulates cell migration (PubMed:17038317). In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (PubMed:14978216). Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation (By similarity). Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups (PubMed:26465210). {ECO:0000250|UniProtKB:P60766, ECO:0000250|UniProtKB:Q8CFN2, ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:17038317, ECO:0000269|PubMed:26465210}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for EIF4G3-CDC42 |
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Fusion Gene PPI Analysis for EIF4G3-CDC42 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for EIF4G3-CDC42 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for EIF4G3-CDC42 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C0036341 | Schizophrenia | 4 | PSYGENET | |
Tgene | C4225222 | TAKENOUCHI-KOSAKI SYNDROME | 3 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
Tgene | C0001624 | Adrenal Gland Neoplasms | 1 | CTD_human | |
Tgene | C0005818 | Blood Platelet Disorders | 1 | GENOMICS_ENGLAND | |
Tgene | C0007097 | Carcinoma | 1 | CTD_human | |
Tgene | C0019693 | HIV Infections | 1 | CTD_human | |
Tgene | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human | |
Tgene | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human | |
Tgene | C0027540 | Necrosis | 1 | CTD_human | |
Tgene | C0205696 | Anaplastic carcinoma | 1 | CTD_human | |
Tgene | C0205697 | Carcinoma, Spindle-Cell | 1 | CTD_human | |
Tgene | C0205698 | Undifferentiated carcinoma | 1 | CTD_human | |
Tgene | C0205699 | Carcinomatosis | 1 | CTD_human | |
Tgene | C0750887 | Adrenal Cancer | 1 | CTD_human | |
Tgene | C1257925 | Mammary Carcinoma, Animal | 1 | CTD_human | |
Tgene | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND | |
Tgene | C4505456 | HIV Coinfection | 1 | CTD_human |