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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CBLB-PGK1 (FusionGDB2 ID:HG868TG5230)

Fusion Gene Summary for CBLB-PGK1

check button Fusion gene summary
Fusion gene informationFusion gene name: CBLB-PGK1
Fusion gene ID: hg868tg5230
HgeneTgene
Gene symbol

CBLB

PGK1

Gene ID

868

5230

Gene nameCbl proto-oncogene Bphosphoglycerate kinase 1
SynonymsCbl-b|Nbla00127|RNF56HEL-S-68p|MIG10|PGKA
Cytomap('CBLB')('PGK1')

3q13.11

Xq21.1

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase CBL-BCas-Br-M (murine) ecotropic retroviral transforming sequence bCbl proto-oncogene B, E3 ubiquitin protein ligaseCbl proto-oncogene, E3 ubiquitin protein ligase BRING finger protein 56RING-type E3 ubiquitin transferase phosphoglycerate kinase 1PRP 2cell migration-inducing gene 10 proteinepididymis secretory sperm binding protein Li 68pprimer recognition protein 2
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000545639, ENST00000264122, 
ENST00000394027, ENST00000403724, 
ENST00000405772, ENST00000407712, 
Fusion gene scores* DoF score10 X 12 X 3=36013 X 12 X 6=936
# samples 1314
** MAII scorelog2(13/360*10)=-1.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/936*10)=-2.74108170263844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CBLB [Title/Abstract] AND PGK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCBLB(105452852)-PGK1(77369512), # samples:1
Anticipated loss of major functional domain due to fusion event.CBLB-PGK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CBLB-PGK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CBLB-PGK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CBLB-PGK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CBLB-PGK1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
CBLB-PGK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CBLB-PGK1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CBLB-PGK1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePGK1

GO:0071456

cellular response to hypoxia

11130727


check buttonFusion gene breakpoints across CBLB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PGK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-04-1651CBLBchr3

105452852

-PGK1chrX

77369512

+


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Fusion Gene ORF analysis for CBLB-PGK1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000545639ENST00000373316CBLBchr3

105452852

-PGK1chrX

77369512

+
3UTR-intronENST00000545639ENST00000442431CBLBchr3

105452852

-PGK1chrX

77369512

+
3UTR-intronENST00000545639ENST00000476531CBLBchr3

105452852

-PGK1chrX

77369512

+
3UTR-intronENST00000545639ENST00000537456CBLBchr3

105452852

-PGK1chrX

77369512

+
5CDS-intronENST00000264122ENST00000442431CBLBchr3

105452852

-PGK1chrX

77369512

+
5CDS-intronENST00000264122ENST00000476531CBLBchr3

105452852

-PGK1chrX

77369512

+
5CDS-intronENST00000264122ENST00000537456CBLBchr3

105452852

-PGK1chrX

77369512

+
5CDS-intronENST00000394027ENST00000442431CBLBchr3

105452852

-PGK1chrX

77369512

+
5CDS-intronENST00000394027ENST00000476531CBLBchr3

105452852

-PGK1chrX

77369512

+
5CDS-intronENST00000394027ENST00000537456CBLBchr3

105452852

-PGK1chrX

77369512

+
5CDS-intronENST00000403724ENST00000442431CBLBchr3

105452852

-PGK1chrX

77369512

+
5CDS-intronENST00000403724ENST00000476531CBLBchr3

105452852

-PGK1chrX

77369512

+
5CDS-intronENST00000403724ENST00000537456CBLBchr3

105452852

-PGK1chrX

77369512

+
5CDS-intronENST00000405772ENST00000442431CBLBchr3

105452852

-PGK1chrX

77369512

+
5CDS-intronENST00000405772ENST00000476531CBLBchr3

105452852

-PGK1chrX

77369512

+
5CDS-intronENST00000405772ENST00000537456CBLBchr3

105452852

-PGK1chrX

77369512

+
Frame-shiftENST00000394027ENST00000373316CBLBchr3

105452852

-PGK1chrX

77369512

+
In-frameENST00000264122ENST00000373316CBLBchr3

105452852

-PGK1chrX

77369512

+
In-frameENST00000403724ENST00000373316CBLBchr3

105452852

-PGK1chrX

77369512

+
In-frameENST00000405772ENST00000373316CBLBchr3

105452852

-PGK1chrX

77369512

+
intron-3CDSENST00000407712ENST00000373316CBLBchr3

105452852

-PGK1chrX

77369512

+
intron-intronENST00000407712ENST00000442431CBLBchr3

105452852

-PGK1chrX

77369512

+
intron-intronENST00000407712ENST00000476531CBLBchr3

105452852

-PGK1chrX

77369512

+
intron-intronENST00000407712ENST00000537456CBLBchr3

105452852

-PGK1chrX

77369512

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264122CBLBchr3105452852-ENST00000373316PGK1chrX77369512+597315251361674512
ENST00000403724CBLBchr3105452852-ENST00000373316PGK1chrX77369512+597315251361674512
ENST00000405772CBLBchr3105452852-ENST00000373316PGK1chrX77369512+597315251361674512

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264122ENST00000373316CBLBchr3105452852-PGK1chrX77369512+0.0014422930.99855775
ENST00000403724ENST00000373316CBLBchr3105452852-PGK1chrX77369512+0.0014422930.99855775
ENST00000405772ENST00000373316CBLBchr3105452852-PGK1chrX77369512+0.0014422930.99855775

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Fusion Genomic Features for CBLB-PGK1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CBLBchr3105452852-PGK1chrX77369512+4.80E-050.99995196
CBLBchr3105452852-PGK1chrX77369512+4.80E-050.99995196

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CBLB-PGK1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:105452852/chrX:77369512)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCBLBchr3:105452852chrX:77369512ENST00000264122-919219_232401983.0Calcium bindingOntology_term=ECO:0000255
HgeneCBLBchr3:105452852chrX:77369512ENST00000403724-915219_232401771.0Calcium bindingOntology_term=ECO:0000255
HgeneCBLBchr3:105452852chrX:77369512ENST00000264122-91935_343401983.0DomainCbl-PTB
HgeneCBLBchr3:105452852chrX:77369512ENST00000403724-91535_343401771.0DomainCbl-PTB
HgeneCBLBchr3:105452852chrX:77369512ENST00000264122-919168_240401983.0RegionNote=EF-hand-like
HgeneCBLBchr3:105452852chrX:77369512ENST00000264122-919241_343401983.0RegionNote=SH2-like
HgeneCBLBchr3:105452852chrX:77369512ENST00000264122-919344_372401983.0RegionNote=Linker
HgeneCBLBchr3:105452852chrX:77369512ENST00000264122-91935_167401983.0RegionNote=4H
HgeneCBLBchr3:105452852chrX:77369512ENST00000403724-915168_240401771.0RegionNote=EF-hand-like
HgeneCBLBchr3:105452852chrX:77369512ENST00000403724-915241_343401771.0RegionNote=SH2-like
HgeneCBLBchr3:105452852chrX:77369512ENST00000403724-915344_372401771.0RegionNote=Linker
HgeneCBLBchr3:105452852chrX:77369512ENST00000403724-91535_167401771.0RegionNote=4H
TgenePGK1chr3:105452852chrX:77369512ENST00000373316211373_37690418.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCBLBchr3:105452852chrX:77369512ENST00000264122-919477_925401983.0Compositional biasNote=Pro-rich
HgeneCBLBchr3:105452852chrX:77369512ENST00000403724-915477_925401771.0Compositional biasNote=Pro-rich
HgeneCBLBchr3:105452852chrX:77369512ENST00000264122-919931_970401983.0DomainUBA
HgeneCBLBchr3:105452852chrX:77369512ENST00000403724-915931_970401771.0DomainUBA
HgeneCBLBchr3:105452852chrX:77369512ENST00000264122-919373_412401983.0Zinc fingerRING-type
HgeneCBLBchr3:105452852chrX:77369512ENST00000403724-915373_412401771.0Zinc fingerRING-type
TgenePGK1chr3:105452852chrX:77369512ENST0000037331621124_2690418.0RegionSubstrate binding
TgenePGK1chr3:105452852chrX:77369512ENST0000037331621163_6690418.0RegionSubstrate binding


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Fusion Gene Sequence for CBLB-PGK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>13387_13387_1_CBLB-PGK1_CBLB_chr3_105452852_ENST00000264122_PGK1_chrX_77369512_ENST00000373316_length(transcript)=5973nt_BP=1525nt
CTGGGTCCTGTGTGTGCCACAGGGGTGGGGTGTCCAGCGAGCGGTCTCCTCCTCCTGCTAGTGCTGCTGCGGCGTCCCGCGGCCTCCCCG
AGTCGGGCGGGAGGGGAGAGCGGGTGTGGATTTGTCTTGACGGTAATTGTTGCGTTTCCACGTCTCGGAGGCCTGCGCGCTGGGTTGCTC
CTTCTTCGGGAGCGAGCTGTTCTCAGCGATCCCACTCCCAGCCGGGGCTCCCCACACACACTGGGCTGCGTGCGTGTGGAGTGGGACCCG
CGCACACGCGTGTCTCTGGACAGCTACGGCGCCGAAAGAACTAAAATTCCAGATGGCAAACTCAATGAATGGCAGAAACCCTGGTGGTCG
AGGAGGAAATCCCCGAAAAGGTCGAATTTTGGGTATTATTGATGCTATTCAGGATGCAGTTGGACCCCCTAAGCAAGCTGCCGCAGATCG
CAGGACCGTGGAGAAGACTTGGAAGCTCATGGACAAAGTGGTAAGACTGTGCCAAAATCCCAAACTTCAGTTGAAAAATAGCCCACCATA
TATACTTGATATTTTGCCTGATACATATCAGCATTTACGACTTATATTGAGTAAATATGATGACAACCAGAAACTTGCCCAACTCAGTGA
GAATGAGTACTTTAAAATCTACATTGATAGCCTTATGAAAAAGTCAAAACGGGCAATAAGACTCTTTAAAGAAGGCAAGGAGAGAATGTA
TGAAGAACAGTCACAGGACAGACGAAATCTCACAAAACTGTCCCTTATCTTCAGTCACATGCTGGCAGAAATCAAAGCAATCTTTCCCAA
TGGTCAATTCCAGGGAGATAACTTTCGTATCACAAAAGCAGATGCTGCTGAATTCTGGAGAAAGTTTTTTGGAGACAAAACTATCGTACC
ATGGAAAGTATTCAGACAGTGCCTTCATGAGGTCCACCAGATTAGCTCTGGCCTGGAAGCAATGGCTCTAAAATCAACAATTGATTTAAC
TTGCAATGATTACATTTCAGTTTTTGAATTTGATATTTTTACCAGGCTGTTTCAGCCTTGGGGCTCTATTTTGCGGAATTGGAATTTCTT
AGCTGTGACACATCCAGGTTACATGGCATTTCTCACATATGATGAAGTTAAAGCACGACTACAGAAATATAGCACCAAACCCGGAAGCTA
TATTTTCCGGTTAAGTTGCACTCGATTGGGACAGTGGGCCATTGGCTATGTGACTGGGGATGGGAATATCTTACAGACCATACCTCATAA
CAAGCCCTTATTTCAAGCCCTGATTGATGGCAGCAGGGAAGGATTTTATCTTTATCCTGATGGGAGGAGTTATAATCCTGATTTAACTGG
ATTATGTGAACCTACACCTCATGACCATATAAAAGTTACACAGGAACAATATGAATTATATTGTGAAATGGGCTCCACTTTTCAGCTCTG
TAAGATTTGTGCAGAGAATGACAAAGATGTCAAGATTGAGCCTTGTGGGCATTTGATGTGCACCTCTTGCCTTACGGCATGGCAGGGATG
TTCTGTTCTTGAAGGACTGTGTAGGCCCAGAAGTGGAGAAAGCCTGTGCCAACCCAGCTGCTGGGTCTGTCATCCTGCTGGAGAACCTCC
GCTTTCATGTGGAGGAAGAAGGGAAGGGAAAAGATGCTTCTGGGAACAAGGTTAAAGCCGAGCCAGCCAAAATAGAAGCTTTCCGAGCTT
CACTTTCCAAGCTAGGGGATGTCTATGTCAATGATGCTTTTGGCACTGCTCACAGAGCCCACAGCTCCATGGTAGGAGTCAATCTGCCAC
AGAAGGCTGGTGGGTTTTTGATGAAGAAGGAGCTGAACTACTTTGCAAAGGCCTTGGAGAGCCCAGAGCGACCCTTCCTGGCCATCCTGG
GCGGAGCTAAAGTTGCAGACAAGATCCAGCTCATCAATAATATGCTGGACAAAGTCAATGAGATGATTATTGGTGGTGGAATGGCTTTTA
CCTTCCTTAAGGTGCTCAACAACATGGAGATTGGCACTTCTCTGTTTGATGAAGAGGGAGCCAAGATTGTCAAAGACCTAATGTCCAAAG
CTGAGAAGAATGGTGTGAAGATTACCTTGCCTGTTGACTTTGTCACTGCTGACAAGTTTGATGAGAATGCCAAGACTGGCCAAGCCACTG
TGGCTTCTGGCATACCTGCTGGCTGGATGGGCTTGGACTGTGGTCCTGAAAGCAGCAAGAAGTATGCTGAGGCTGTCACTCGGGCTAAGC
AGATTGTGTGGAATGGTCCTGTGGGGGTATTTGAATGGGAAGCTTTTGCCCGGGGAACCAAAGCTCTCATGGATGAGGTGGTGAAAGCCA
CTTCTAGGGGCTGCATCACCATCATAGGTGGTGGAGACACTGCCACTTGCTGTGCCAAATGGAACACGGAGGATAAAGTCAGCCATGTGA
GCACTGGGGGTGGTGCCAGTTTGGAGCTCCTGGAAGGTAAAGTCCTTCCTGGGGTGGATGCTCTCAGCAATATTTAGTACTTTCCTGCCT
TTTAGTTCCTGTGCACAGCCCCTAAGTCAACTTAGCATTTTCTGCATCTCCACTTGGCATTAGCTAAAACCTTCCATGTCAAGATTCAGC
TAGTGGCCAAGAGATGCAGTGCCAGGAACCCTTAAACAGTTGCACAGCATCTCAGCTCATCTTCACTGCACCCTGGATTTGCATACATTC
TTCAAGATCCCATTTGAATTTTTTAGTGACTAAACCATTGTGCATTCTAGAGTGCATATATTTATATTTTGCCTGTTAAAAAGAAAGTGA
GCAGTGTTAGCTTAGTTCTCTTTTGATGTAGGTTATTATGATTAGCTTTGTCACTGTTTCACTACTCAGCATGGAAACAAGATGAAATTC
CATTTGTAGGTAGTGAGACAAAATTGATGATCCATTAAGTAAACAATAAAAGTGTCCATTGAAACCGTGATTTTTTTTTTTTTCCTGTCA
TACTTTGTTAGGAAGGGTGAGAATAGAATCTTGAGGAACGGATCAGATGTCTATATTGCTGAATGCAAGAAGTGGGGCAGCAGCAGTGGA
GAGATGGGACAATTAGATAAATGTCCATTCTTTATCAAGGGCCTACTTTATGGCAGACATTGTGCTAGTGCTTTTATTCTAACTTTTATT
TTTATCAGTTACACATGATCATAATTTAAAAAGTCAAGGCTTATAACAAAAAAGCCCCAGCCCATTCCTCCCATTCAAGATTCCCACTCC
CCAGAGGTGACCACTTTCAACTCTTGAGTTTTTCAGGTATATACCTCCATGTTTCTAAGTAATATGCTTATATTGTTCACTTCTTTTTTT
TTTATTTTTTAAAGAAATCTATTTCATACCATGGAGGAAGGCTCTGTTCCACATATATTTCCACTTCTTCATTCTCTCGGTATAGTTTTG
TCACAATTATAGATTAGATCAAAAGTCTACATAACTAATACAGCTGAGCTATGTAGTATGCTATGATTAAATTTACTTATGTAACTTTTA
TTGTCTTTGGCATTAACAGTGTTTCAAAAAATTTTCTGTGTATACCCATCAGTGATTCATTCCCAAATCTTCTAGAAGCATAAGTGTCTC
AATATATTAAAACATATTGAATAATCCTTGTTAGAGTTATCCCTGCAGGAGTCCTTAGTGCTCCTTTATCCAATTTGTACTTGATGCCCT
CTAGGCAGGGTGTACAGCTAGCTGTTGCTCTGGTATTTCCTATAACCTTCTTGGGGATTTCTTTTACCTCCTGTGTTAGACTCCTGTTTT
CTGGATTCCCCCTTTTCCCTCTTTCTTGGTCTACTTTTTGTAGAACACAAGACTCTACTAGCTTCCTGAGAAAGGGTGCCTGGGAGGCAA
AATCTCTAAGACTTTGTAAGTCTGAAAATGTCTTTATTCGACCCTTATACTTGATTCCTAGTTTGGCTATATATAGAATTTTAGCCTGAG
TATCACTTTTTGAGACTCGAAGCCACTGTTTCATTGTCACTATTGAGAATCTAAATGGCCATTCGGATTCTTTCATCATCTTTATAATTT
TACCTTCCTATTTCTTTCCTGTCCTTTTAATGGAGTTTTGGGAGAGAGCAGAGGTAAACATGATTTGAAAAAGCCATGTCTGACCAGAAA
TTCTGTGCTGGAAAGATATGTATTTCACCTTTAGGGACAAAGAAATAAACTTTTGGACAGGACCACAGAGCTAGTAAGTAACAGCAGGGA
TTCAAGTCCAGGTTTGTCTGGTTCCAGTGGCTGATGCTTTTCCAATGTGCCTCCGTCCCTGACATGATGCTTCTAGGCTATAGATGCTTC
TAGACTCTATCCCTGACATGATGCTTCTAGACTATTTTGTTTAACCCTGGATAGAATAGCAAAAGAAAATTTTGGTGGTTGCTCTAAACA
AAACAGAAATTTGAAAGCTCAAGTTTTTTCTTCATTTGTATTTTAGTTAATACTGTACCCATATTTGTAGTTAATTTTAAATTGTACCAT
GTTTCTGCATACCTCTATGGGTACTCAGGAATTCTAGTCCAATTTTTGTGACTTTTTCCTACTGATTACCTTTCCTCCAACGTTTTAAAA
ATTATTTCAAATGGAACTGAAAGAAGCATAAACTCCCATAAACCCAGCACCTAGACTCTACAATTGCCAACATTATCTATCCAACAATCT
CTGACTGTACCTTTTAAGTACTTTCTACTGGACTGTTTCCAGGATCACCCCTCATTTATTTGGGTTGTTAACCTAAAGAATGAATGGGGG
AATCTCCAGTCATAAACAACTTGTCAATTAGGCAAATATTTGAGTTCCTTCTATGTGCTTAAAGACGTGATAGAGGGAATATAAGAGCAT
TTATGTTCTGAAGGAATTTTTAACCTAACCAAAGAAGATAGTAGATAACTTGTGTGCATATAAGCTAGAACAGTATAAGGGGCCGGGCAT
GGTGGCTTACGCCTGTAATCCCAGGACTTTGGGAGGCCAAGGCGGGCAGATCACCTGTCAGGAGTTTGGGACCAGCCTGGCCAACATGGT
GAAACCCCGTTTCTACCAAAAATACAAAAATTAGCCGGGCGTGGTGGCGTGTGCCACTGTAGTCCCAGCTATTCAGAAGGCTGAGGCAGG
AGAATCACTTGAACCCGGGAGGTGGAGGTTGCAGTGAGCTGAGATCACGCTACTGCATTCCTGCTTGGGCGACAGAGTGAGACTCTGCCT
CAAAACAAAAACCCCACAAAACAGTATAAGGATGTGCTTTCTAATTTGGAATTATGAATTATTGGTAAAATATTGCAAAGGTGTATGCTT
TAAGTTGTAAATTCACCTTTAACCCTAGACTATATATGTGTGTTTATATGCAGAAAAAAATAATTCCCATGTCGTAAGTGAACAATTTGG
TTCTTTAGCTCAGTGTTTTCCTGTTTTCTTCATTTCCAAAATTTCCCTCTAGCACAGGGGTTTACACATGATCAAAAAGGAGTATACAAT
GAAGACACCTTCCTCAGTCCCCTACCTACCAGTTTCCCTCCCCAGAAGCAACCTCTGGAAGACCAGTTTCTTTCAATCTAAGGCTATTTA
ATATACATTAAGAGGCCGGGCGCAGTGGCTCACGCCTGTAATCCCAACAACACTTTGGGAGGCCCAGGCAGGCGGGTCATGAGGTCAGGA
GATTGAGACCATCCTGGCTAACACGGTGAAACCCTGTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGATGGTGGGCGCCTGTAGTC
CCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCTGGGAAGCGGAGCTCGCAGTGAGCCGAGATCACGCCACTGCACTCCAGC
CTGGGCAACAGTGAGACTCTGCATAAAGAGCATACCCATGTGTGTACCTATCTATCTATCTATCTATCTATCTATCTATCTATCTATCTG

>13387_13387_1_CBLB-PGK1_CBLB_chr3_105452852_ENST00000264122_PGK1_chrX_77369512_ENST00000373316_length(amino acids)=512AA_BP=462
MLRFHVSEACALGCSFFGSELFSAIPLPAGAPHTHWAACVWSGTRAHACLWTATAPKELKFQMANSMNGRNPGGRGGNPRKGRILGIIDA
IQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKS
KRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQIS
SGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIG
YVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPC

--------------------------------------------------------------
>13387_13387_2_CBLB-PGK1_CBLB_chr3_105452852_ENST00000403724_PGK1_chrX_77369512_ENST00000373316_length(transcript)=5973nt_BP=1525nt
CTGGGTCCTGTGTGTGCCACAGGGGTGGGGTGTCCAGCGAGCGGTCTCCTCCTCCTGCTAGTGCTGCTGCGGCGTCCCGCGGCCTCCCCG
AGTCGGGCGGGAGGGGAGAGCGGGTGTGGATTTGTCTTGACGGTAATTGTTGCGTTTCCACGTCTCGGAGGCCTGCGCGCTGGGTTGCTC
CTTCTTCGGGAGCGAGCTGTTCTCAGCGATCCCACTCCCAGCCGGGGCTCCCCACACACACTGGGCTGCGTGCGTGTGGAGTGGGACCCG
CGCACACGCGTGTCTCTGGACAGCTACGGCGCCGAAAGAACTAAAATTCCAGATGGCAAACTCAATGAATGGCAGAAACCCTGGTGGTCG
AGGAGGAAATCCCCGAAAAGGTCGAATTTTGGGTATTATTGATGCTATTCAGGATGCAGTTGGACCCCCTAAGCAAGCTGCCGCAGATCG
CAGGACCGTGGAGAAGACTTGGAAGCTCATGGACAAAGTGGTAAGACTGTGCCAAAATCCCAAACTTCAGTTGAAAAATAGCCCACCATA
TATACTTGATATTTTGCCTGATACATATCAGCATTTACGACTTATATTGAGTAAATATGATGACAACCAGAAACTTGCCCAACTCAGTGA
GAATGAGTACTTTAAAATCTACATTGATAGCCTTATGAAAAAGTCAAAACGGGCAATAAGACTCTTTAAAGAAGGCAAGGAGAGAATGTA
TGAAGAACAGTCACAGGACAGACGAAATCTCACAAAACTGTCCCTTATCTTCAGTCACATGCTGGCAGAAATCAAAGCAATCTTTCCCAA
TGGTCAATTCCAGGGAGATAACTTTCGTATCACAAAAGCAGATGCTGCTGAATTCTGGAGAAAGTTTTTTGGAGACAAAACTATCGTACC
ATGGAAAGTATTCAGACAGTGCCTTCATGAGGTCCACCAGATTAGCTCTGGCCTGGAAGCAATGGCTCTAAAATCAACAATTGATTTAAC
TTGCAATGATTACATTTCAGTTTTTGAATTTGATATTTTTACCAGGCTGTTTCAGCCTTGGGGCTCTATTTTGCGGAATTGGAATTTCTT
AGCTGTGACACATCCAGGTTACATGGCATTTCTCACATATGATGAAGTTAAAGCACGACTACAGAAATATAGCACCAAACCCGGAAGCTA
TATTTTCCGGTTAAGTTGCACTCGATTGGGACAGTGGGCCATTGGCTATGTGACTGGGGATGGGAATATCTTACAGACCATACCTCATAA
CAAGCCCTTATTTCAAGCCCTGATTGATGGCAGCAGGGAAGGATTTTATCTTTATCCTGATGGGAGGAGTTATAATCCTGATTTAACTGG
ATTATGTGAACCTACACCTCATGACCATATAAAAGTTACACAGGAACAATATGAATTATATTGTGAAATGGGCTCCACTTTTCAGCTCTG
TAAGATTTGTGCAGAGAATGACAAAGATGTCAAGATTGAGCCTTGTGGGCATTTGATGTGCACCTCTTGCCTTACGGCATGGCAGGGATG
TTCTGTTCTTGAAGGACTGTGTAGGCCCAGAAGTGGAGAAAGCCTGTGCCAACCCAGCTGCTGGGTCTGTCATCCTGCTGGAGAACCTCC
GCTTTCATGTGGAGGAAGAAGGGAAGGGAAAAGATGCTTCTGGGAACAAGGTTAAAGCCGAGCCAGCCAAAATAGAAGCTTTCCGAGCTT
CACTTTCCAAGCTAGGGGATGTCTATGTCAATGATGCTTTTGGCACTGCTCACAGAGCCCACAGCTCCATGGTAGGAGTCAATCTGCCAC
AGAAGGCTGGTGGGTTTTTGATGAAGAAGGAGCTGAACTACTTTGCAAAGGCCTTGGAGAGCCCAGAGCGACCCTTCCTGGCCATCCTGG
GCGGAGCTAAAGTTGCAGACAAGATCCAGCTCATCAATAATATGCTGGACAAAGTCAATGAGATGATTATTGGTGGTGGAATGGCTTTTA
CCTTCCTTAAGGTGCTCAACAACATGGAGATTGGCACTTCTCTGTTTGATGAAGAGGGAGCCAAGATTGTCAAAGACCTAATGTCCAAAG
CTGAGAAGAATGGTGTGAAGATTACCTTGCCTGTTGACTTTGTCACTGCTGACAAGTTTGATGAGAATGCCAAGACTGGCCAAGCCACTG
TGGCTTCTGGCATACCTGCTGGCTGGATGGGCTTGGACTGTGGTCCTGAAAGCAGCAAGAAGTATGCTGAGGCTGTCACTCGGGCTAAGC
AGATTGTGTGGAATGGTCCTGTGGGGGTATTTGAATGGGAAGCTTTTGCCCGGGGAACCAAAGCTCTCATGGATGAGGTGGTGAAAGCCA
CTTCTAGGGGCTGCATCACCATCATAGGTGGTGGAGACACTGCCACTTGCTGTGCCAAATGGAACACGGAGGATAAAGTCAGCCATGTGA
GCACTGGGGGTGGTGCCAGTTTGGAGCTCCTGGAAGGTAAAGTCCTTCCTGGGGTGGATGCTCTCAGCAATATTTAGTACTTTCCTGCCT
TTTAGTTCCTGTGCACAGCCCCTAAGTCAACTTAGCATTTTCTGCATCTCCACTTGGCATTAGCTAAAACCTTCCATGTCAAGATTCAGC
TAGTGGCCAAGAGATGCAGTGCCAGGAACCCTTAAACAGTTGCACAGCATCTCAGCTCATCTTCACTGCACCCTGGATTTGCATACATTC
TTCAAGATCCCATTTGAATTTTTTAGTGACTAAACCATTGTGCATTCTAGAGTGCATATATTTATATTTTGCCTGTTAAAAAGAAAGTGA
GCAGTGTTAGCTTAGTTCTCTTTTGATGTAGGTTATTATGATTAGCTTTGTCACTGTTTCACTACTCAGCATGGAAACAAGATGAAATTC
CATTTGTAGGTAGTGAGACAAAATTGATGATCCATTAAGTAAACAATAAAAGTGTCCATTGAAACCGTGATTTTTTTTTTTTTCCTGTCA
TACTTTGTTAGGAAGGGTGAGAATAGAATCTTGAGGAACGGATCAGATGTCTATATTGCTGAATGCAAGAAGTGGGGCAGCAGCAGTGGA
GAGATGGGACAATTAGATAAATGTCCATTCTTTATCAAGGGCCTACTTTATGGCAGACATTGTGCTAGTGCTTTTATTCTAACTTTTATT
TTTATCAGTTACACATGATCATAATTTAAAAAGTCAAGGCTTATAACAAAAAAGCCCCAGCCCATTCCTCCCATTCAAGATTCCCACTCC
CCAGAGGTGACCACTTTCAACTCTTGAGTTTTTCAGGTATATACCTCCATGTTTCTAAGTAATATGCTTATATTGTTCACTTCTTTTTTT
TTTATTTTTTAAAGAAATCTATTTCATACCATGGAGGAAGGCTCTGTTCCACATATATTTCCACTTCTTCATTCTCTCGGTATAGTTTTG
TCACAATTATAGATTAGATCAAAAGTCTACATAACTAATACAGCTGAGCTATGTAGTATGCTATGATTAAATTTACTTATGTAACTTTTA
TTGTCTTTGGCATTAACAGTGTTTCAAAAAATTTTCTGTGTATACCCATCAGTGATTCATTCCCAAATCTTCTAGAAGCATAAGTGTCTC
AATATATTAAAACATATTGAATAATCCTTGTTAGAGTTATCCCTGCAGGAGTCCTTAGTGCTCCTTTATCCAATTTGTACTTGATGCCCT
CTAGGCAGGGTGTACAGCTAGCTGTTGCTCTGGTATTTCCTATAACCTTCTTGGGGATTTCTTTTACCTCCTGTGTTAGACTCCTGTTTT
CTGGATTCCCCCTTTTCCCTCTTTCTTGGTCTACTTTTTGTAGAACACAAGACTCTACTAGCTTCCTGAGAAAGGGTGCCTGGGAGGCAA
AATCTCTAAGACTTTGTAAGTCTGAAAATGTCTTTATTCGACCCTTATACTTGATTCCTAGTTTGGCTATATATAGAATTTTAGCCTGAG
TATCACTTTTTGAGACTCGAAGCCACTGTTTCATTGTCACTATTGAGAATCTAAATGGCCATTCGGATTCTTTCATCATCTTTATAATTT
TACCTTCCTATTTCTTTCCTGTCCTTTTAATGGAGTTTTGGGAGAGAGCAGAGGTAAACATGATTTGAAAAAGCCATGTCTGACCAGAAA
TTCTGTGCTGGAAAGATATGTATTTCACCTTTAGGGACAAAGAAATAAACTTTTGGACAGGACCACAGAGCTAGTAAGTAACAGCAGGGA
TTCAAGTCCAGGTTTGTCTGGTTCCAGTGGCTGATGCTTTTCCAATGTGCCTCCGTCCCTGACATGATGCTTCTAGGCTATAGATGCTTC
TAGACTCTATCCCTGACATGATGCTTCTAGACTATTTTGTTTAACCCTGGATAGAATAGCAAAAGAAAATTTTGGTGGTTGCTCTAAACA
AAACAGAAATTTGAAAGCTCAAGTTTTTTCTTCATTTGTATTTTAGTTAATACTGTACCCATATTTGTAGTTAATTTTAAATTGTACCAT
GTTTCTGCATACCTCTATGGGTACTCAGGAATTCTAGTCCAATTTTTGTGACTTTTTCCTACTGATTACCTTTCCTCCAACGTTTTAAAA
ATTATTTCAAATGGAACTGAAAGAAGCATAAACTCCCATAAACCCAGCACCTAGACTCTACAATTGCCAACATTATCTATCCAACAATCT
CTGACTGTACCTTTTAAGTACTTTCTACTGGACTGTTTCCAGGATCACCCCTCATTTATTTGGGTTGTTAACCTAAAGAATGAATGGGGG
AATCTCCAGTCATAAACAACTTGTCAATTAGGCAAATATTTGAGTTCCTTCTATGTGCTTAAAGACGTGATAGAGGGAATATAAGAGCAT
TTATGTTCTGAAGGAATTTTTAACCTAACCAAAGAAGATAGTAGATAACTTGTGTGCATATAAGCTAGAACAGTATAAGGGGCCGGGCAT
GGTGGCTTACGCCTGTAATCCCAGGACTTTGGGAGGCCAAGGCGGGCAGATCACCTGTCAGGAGTTTGGGACCAGCCTGGCCAACATGGT
GAAACCCCGTTTCTACCAAAAATACAAAAATTAGCCGGGCGTGGTGGCGTGTGCCACTGTAGTCCCAGCTATTCAGAAGGCTGAGGCAGG
AGAATCACTTGAACCCGGGAGGTGGAGGTTGCAGTGAGCTGAGATCACGCTACTGCATTCCTGCTTGGGCGACAGAGTGAGACTCTGCCT
CAAAACAAAAACCCCACAAAACAGTATAAGGATGTGCTTTCTAATTTGGAATTATGAATTATTGGTAAAATATTGCAAAGGTGTATGCTT
TAAGTTGTAAATTCACCTTTAACCCTAGACTATATATGTGTGTTTATATGCAGAAAAAAATAATTCCCATGTCGTAAGTGAACAATTTGG
TTCTTTAGCTCAGTGTTTTCCTGTTTTCTTCATTTCCAAAATTTCCCTCTAGCACAGGGGTTTACACATGATCAAAAAGGAGTATACAAT
GAAGACACCTTCCTCAGTCCCCTACCTACCAGTTTCCCTCCCCAGAAGCAACCTCTGGAAGACCAGTTTCTTTCAATCTAAGGCTATTTA
ATATACATTAAGAGGCCGGGCGCAGTGGCTCACGCCTGTAATCCCAACAACACTTTGGGAGGCCCAGGCAGGCGGGTCATGAGGTCAGGA
GATTGAGACCATCCTGGCTAACACGGTGAAACCCTGTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGATGGTGGGCGCCTGTAGTC
CCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCTGGGAAGCGGAGCTCGCAGTGAGCCGAGATCACGCCACTGCACTCCAGC
CTGGGCAACAGTGAGACTCTGCATAAAGAGCATACCCATGTGTGTACCTATCTATCTATCTATCTATCTATCTATCTATCTATCTATCTG

>13387_13387_2_CBLB-PGK1_CBLB_chr3_105452852_ENST00000403724_PGK1_chrX_77369512_ENST00000373316_length(amino acids)=512AA_BP=462
MLRFHVSEACALGCSFFGSELFSAIPLPAGAPHTHWAACVWSGTRAHACLWTATAPKELKFQMANSMNGRNPGGRGGNPRKGRILGIIDA
IQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKS
KRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQIS
SGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIG
YVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPC

--------------------------------------------------------------
>13387_13387_3_CBLB-PGK1_CBLB_chr3_105452852_ENST00000405772_PGK1_chrX_77369512_ENST00000373316_length(transcript)=5973nt_BP=1525nt
CTGGGTCCTGTGTGTGCCACAGGGGTGGGGTGTCCAGCGAGCGGTCTCCTCCTCCTGCTAGTGCTGCTGCGGCGTCCCGCGGCCTCCCCG
AGTCGGGCGGGAGGGGAGAGCGGGTGTGGATTTGTCTTGACGGTAATTGTTGCGTTTCCACGTCTCGGAGGCCTGCGCGCTGGGTTGCTC
CTTCTTCGGGAGCGAGCTGTTCTCAGCGATCCCACTCCCAGCCGGGGCTCCCCACACACACTGGGCTGCGTGCGTGTGGAGTGGGACCCG
CGCACACGCGTGTCTCTGGACAGCTACGGCGCCGAAAGAACTAAAATTCCAGATGGCAAACTCAATGAATGGCAGAAACCCTGGTGGTCG
AGGAGGAAATCCCCGAAAAGGTCGAATTTTGGGTATTATTGATGCTATTCAGGATGCAGTTGGACCCCCTAAGCAAGCTGCCGCAGATCG
CAGGACCGTGGAGAAGACTTGGAAGCTCATGGACAAAGTGGTAAGACTGTGCCAAAATCCCAAACTTCAGTTGAAAAATAGCCCACCATA
TATACTTGATATTTTGCCTGATACATATCAGCATTTACGACTTATATTGAGTAAATATGATGACAACCAGAAACTTGCCCAACTCAGTGA
GAATGAGTACTTTAAAATCTACATTGATAGCCTTATGAAAAAGTCAAAACGGGCAATAAGACTCTTTAAAGAAGGCAAGGAGAGAATGTA
TGAAGAACAGTCACAGGACAGACGAAATCTCACAAAACTGTCCCTTATCTTCAGTCACATGCTGGCAGAAATCAAAGCAATCTTTCCCAA
TGGTCAATTCCAGGGAGATAACTTTCGTATCACAAAAGCAGATGCTGCTGAATTCTGGAGAAAGTTTTTTGGAGACAAAACTATCGTACC
ATGGAAAGTATTCAGACAGTGCCTTCATGAGGTCCACCAGATTAGCTCTGGCCTGGAAGCAATGGCTCTAAAATCAACAATTGATTTAAC
TTGCAATGATTACATTTCAGTTTTTGAATTTGATATTTTTACCAGGCTGTTTCAGCCTTGGGGCTCTATTTTGCGGAATTGGAATTTCTT
AGCTGTGACACATCCAGGTTACATGGCATTTCTCACATATGATGAAGTTAAAGCACGACTACAGAAATATAGCACCAAACCCGGAAGCTA
TATTTTCCGGTTAAGTTGCACTCGATTGGGACAGTGGGCCATTGGCTATGTGACTGGGGATGGGAATATCTTACAGACCATACCTCATAA
CAAGCCCTTATTTCAAGCCCTGATTGATGGCAGCAGGGAAGGATTTTATCTTTATCCTGATGGGAGGAGTTATAATCCTGATTTAACTGG
ATTATGTGAACCTACACCTCATGACCATATAAAAGTTACACAGGAACAATATGAATTATATTGTGAAATGGGCTCCACTTTTCAGCTCTG
TAAGATTTGTGCAGAGAATGACAAAGATGTCAAGATTGAGCCTTGTGGGCATTTGATGTGCACCTCTTGCCTTACGGCATGGCAGGGATG
TTCTGTTCTTGAAGGACTGTGTAGGCCCAGAAGTGGAGAAAGCCTGTGCCAACCCAGCTGCTGGGTCTGTCATCCTGCTGGAGAACCTCC
GCTTTCATGTGGAGGAAGAAGGGAAGGGAAAAGATGCTTCTGGGAACAAGGTTAAAGCCGAGCCAGCCAAAATAGAAGCTTTCCGAGCTT
CACTTTCCAAGCTAGGGGATGTCTATGTCAATGATGCTTTTGGCACTGCTCACAGAGCCCACAGCTCCATGGTAGGAGTCAATCTGCCAC
AGAAGGCTGGTGGGTTTTTGATGAAGAAGGAGCTGAACTACTTTGCAAAGGCCTTGGAGAGCCCAGAGCGACCCTTCCTGGCCATCCTGG
GCGGAGCTAAAGTTGCAGACAAGATCCAGCTCATCAATAATATGCTGGACAAAGTCAATGAGATGATTATTGGTGGTGGAATGGCTTTTA
CCTTCCTTAAGGTGCTCAACAACATGGAGATTGGCACTTCTCTGTTTGATGAAGAGGGAGCCAAGATTGTCAAAGACCTAATGTCCAAAG
CTGAGAAGAATGGTGTGAAGATTACCTTGCCTGTTGACTTTGTCACTGCTGACAAGTTTGATGAGAATGCCAAGACTGGCCAAGCCACTG
TGGCTTCTGGCATACCTGCTGGCTGGATGGGCTTGGACTGTGGTCCTGAAAGCAGCAAGAAGTATGCTGAGGCTGTCACTCGGGCTAAGC
AGATTGTGTGGAATGGTCCTGTGGGGGTATTTGAATGGGAAGCTTTTGCCCGGGGAACCAAAGCTCTCATGGATGAGGTGGTGAAAGCCA
CTTCTAGGGGCTGCATCACCATCATAGGTGGTGGAGACACTGCCACTTGCTGTGCCAAATGGAACACGGAGGATAAAGTCAGCCATGTGA
GCACTGGGGGTGGTGCCAGTTTGGAGCTCCTGGAAGGTAAAGTCCTTCCTGGGGTGGATGCTCTCAGCAATATTTAGTACTTTCCTGCCT
TTTAGTTCCTGTGCACAGCCCCTAAGTCAACTTAGCATTTTCTGCATCTCCACTTGGCATTAGCTAAAACCTTCCATGTCAAGATTCAGC
TAGTGGCCAAGAGATGCAGTGCCAGGAACCCTTAAACAGTTGCACAGCATCTCAGCTCATCTTCACTGCACCCTGGATTTGCATACATTC
TTCAAGATCCCATTTGAATTTTTTAGTGACTAAACCATTGTGCATTCTAGAGTGCATATATTTATATTTTGCCTGTTAAAAAGAAAGTGA
GCAGTGTTAGCTTAGTTCTCTTTTGATGTAGGTTATTATGATTAGCTTTGTCACTGTTTCACTACTCAGCATGGAAACAAGATGAAATTC
CATTTGTAGGTAGTGAGACAAAATTGATGATCCATTAAGTAAACAATAAAAGTGTCCATTGAAACCGTGATTTTTTTTTTTTTCCTGTCA
TACTTTGTTAGGAAGGGTGAGAATAGAATCTTGAGGAACGGATCAGATGTCTATATTGCTGAATGCAAGAAGTGGGGCAGCAGCAGTGGA
GAGATGGGACAATTAGATAAATGTCCATTCTTTATCAAGGGCCTACTTTATGGCAGACATTGTGCTAGTGCTTTTATTCTAACTTTTATT
TTTATCAGTTACACATGATCATAATTTAAAAAGTCAAGGCTTATAACAAAAAAGCCCCAGCCCATTCCTCCCATTCAAGATTCCCACTCC
CCAGAGGTGACCACTTTCAACTCTTGAGTTTTTCAGGTATATACCTCCATGTTTCTAAGTAATATGCTTATATTGTTCACTTCTTTTTTT
TTTATTTTTTAAAGAAATCTATTTCATACCATGGAGGAAGGCTCTGTTCCACATATATTTCCACTTCTTCATTCTCTCGGTATAGTTTTG
TCACAATTATAGATTAGATCAAAAGTCTACATAACTAATACAGCTGAGCTATGTAGTATGCTATGATTAAATTTACTTATGTAACTTTTA
TTGTCTTTGGCATTAACAGTGTTTCAAAAAATTTTCTGTGTATACCCATCAGTGATTCATTCCCAAATCTTCTAGAAGCATAAGTGTCTC
AATATATTAAAACATATTGAATAATCCTTGTTAGAGTTATCCCTGCAGGAGTCCTTAGTGCTCCTTTATCCAATTTGTACTTGATGCCCT
CTAGGCAGGGTGTACAGCTAGCTGTTGCTCTGGTATTTCCTATAACCTTCTTGGGGATTTCTTTTACCTCCTGTGTTAGACTCCTGTTTT
CTGGATTCCCCCTTTTCCCTCTTTCTTGGTCTACTTTTTGTAGAACACAAGACTCTACTAGCTTCCTGAGAAAGGGTGCCTGGGAGGCAA
AATCTCTAAGACTTTGTAAGTCTGAAAATGTCTTTATTCGACCCTTATACTTGATTCCTAGTTTGGCTATATATAGAATTTTAGCCTGAG
TATCACTTTTTGAGACTCGAAGCCACTGTTTCATTGTCACTATTGAGAATCTAAATGGCCATTCGGATTCTTTCATCATCTTTATAATTT
TACCTTCCTATTTCTTTCCTGTCCTTTTAATGGAGTTTTGGGAGAGAGCAGAGGTAAACATGATTTGAAAAAGCCATGTCTGACCAGAAA
TTCTGTGCTGGAAAGATATGTATTTCACCTTTAGGGACAAAGAAATAAACTTTTGGACAGGACCACAGAGCTAGTAAGTAACAGCAGGGA
TTCAAGTCCAGGTTTGTCTGGTTCCAGTGGCTGATGCTTTTCCAATGTGCCTCCGTCCCTGACATGATGCTTCTAGGCTATAGATGCTTC
TAGACTCTATCCCTGACATGATGCTTCTAGACTATTTTGTTTAACCCTGGATAGAATAGCAAAAGAAAATTTTGGTGGTTGCTCTAAACA
AAACAGAAATTTGAAAGCTCAAGTTTTTTCTTCATTTGTATTTTAGTTAATACTGTACCCATATTTGTAGTTAATTTTAAATTGTACCAT
GTTTCTGCATACCTCTATGGGTACTCAGGAATTCTAGTCCAATTTTTGTGACTTTTTCCTACTGATTACCTTTCCTCCAACGTTTTAAAA
ATTATTTCAAATGGAACTGAAAGAAGCATAAACTCCCATAAACCCAGCACCTAGACTCTACAATTGCCAACATTATCTATCCAACAATCT
CTGACTGTACCTTTTAAGTACTTTCTACTGGACTGTTTCCAGGATCACCCCTCATTTATTTGGGTTGTTAACCTAAAGAATGAATGGGGG
AATCTCCAGTCATAAACAACTTGTCAATTAGGCAAATATTTGAGTTCCTTCTATGTGCTTAAAGACGTGATAGAGGGAATATAAGAGCAT
TTATGTTCTGAAGGAATTTTTAACCTAACCAAAGAAGATAGTAGATAACTTGTGTGCATATAAGCTAGAACAGTATAAGGGGCCGGGCAT
GGTGGCTTACGCCTGTAATCCCAGGACTTTGGGAGGCCAAGGCGGGCAGATCACCTGTCAGGAGTTTGGGACCAGCCTGGCCAACATGGT
GAAACCCCGTTTCTACCAAAAATACAAAAATTAGCCGGGCGTGGTGGCGTGTGCCACTGTAGTCCCAGCTATTCAGAAGGCTGAGGCAGG
AGAATCACTTGAACCCGGGAGGTGGAGGTTGCAGTGAGCTGAGATCACGCTACTGCATTCCTGCTTGGGCGACAGAGTGAGACTCTGCCT
CAAAACAAAAACCCCACAAAACAGTATAAGGATGTGCTTTCTAATTTGGAATTATGAATTATTGGTAAAATATTGCAAAGGTGTATGCTT
TAAGTTGTAAATTCACCTTTAACCCTAGACTATATATGTGTGTTTATATGCAGAAAAAAATAATTCCCATGTCGTAAGTGAACAATTTGG
TTCTTTAGCTCAGTGTTTTCCTGTTTTCTTCATTTCCAAAATTTCCCTCTAGCACAGGGGTTTACACATGATCAAAAAGGAGTATACAAT
GAAGACACCTTCCTCAGTCCCCTACCTACCAGTTTCCCTCCCCAGAAGCAACCTCTGGAAGACCAGTTTCTTTCAATCTAAGGCTATTTA
ATATACATTAAGAGGCCGGGCGCAGTGGCTCACGCCTGTAATCCCAACAACACTTTGGGAGGCCCAGGCAGGCGGGTCATGAGGTCAGGA
GATTGAGACCATCCTGGCTAACACGGTGAAACCCTGTCTCTACTAAAAATACAAAAAATTAGCTGGGCGTGATGGTGGGCGCCTGTAGTC
CCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCTGGGAAGCGGAGCTCGCAGTGAGCCGAGATCACGCCACTGCACTCCAGC
CTGGGCAACAGTGAGACTCTGCATAAAGAGCATACCCATGTGTGTACCTATCTATCTATCTATCTATCTATCTATCTATCTATCTATCTG

>13387_13387_3_CBLB-PGK1_CBLB_chr3_105452852_ENST00000405772_PGK1_chrX_77369512_ENST00000373316_length(amino acids)=512AA_BP=462
MLRFHVSEACALGCSFFGSELFSAIPLPAGAPHTHWAACVWSGTRAHACLWTATAPKELKFQMANSMNGRNPGGRGGNPRKGRILGIIDA
IQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKS
KRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQIS
SGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIG
YVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPC

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CBLB-PGK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCBLBchr3:105452852chrX:77369512ENST00000264122-919891_927401.0983.0SH3KBP1
HgeneCBLBchr3:105452852chrX:77369512ENST00000403724-915891_927401.0771.0SH3KBP1
HgeneCBLBchr3:105452852chrX:77369512ENST00000264122-919543_568401.0983.0VAV1
HgeneCBLBchr3:105452852chrX:77369512ENST00000403724-915543_568401.0771.0VAV1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CBLB-PGK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CBLB-PGK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCBLBC0014072Experimental Autoimmune Encephalomyelitis1CTD_human
HgeneCBLBC0026769Multiple Sclerosis1CTD_human
HgeneCBLBC0751324Multiple Sclerosis, Acute Fulminating1CTD_human
TgeneC1970848Phosphoglycerate Kinase 1 Deficiency11CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0007134Renal Cell Carcinoma1CTD_human
TgeneC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
TgeneC0684324Deficiency of phosphoglycerate kinase1ORPHANET
TgeneC1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneC1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneC1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneC1306837Papillary Renal Cell Carcinoma1CTD_human
TgeneC2239176Liver carcinoma1CTD_human