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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ABCC3-BCAN (FusionGDB2 ID:HG8714TG63827)

Fusion Gene Summary for ABCC3-BCAN

check button Fusion gene summary
Fusion gene informationFusion gene name: ABCC3-BCAN
Fusion gene ID: hg8714tg63827
HgeneTgene
Gene symbol

ABCC3

BCAN

Gene ID

8714

63827

Gene nameATP binding cassette subfamily C member 3brevican
SynonymsABC31|EST90757|MLP2|MOAT-D|MRP3|cMOAT2BEHAB|CSPG7
Cytomap('ABCC3')('BCAN')

17q21.33

1q23.1

Type of geneprotein-codingprotein-coding
Descriptioncanalicular multispecific organic anion transporter 2ATP-binding cassette sub-family C member 3ATP-binding cassette, sub-family C (CFTR/MRP), member 3canicular multispecific organic anion transportermulti-specific organic anion transporter Dmultidrugbrevican core proteinbrain-enriched hyaluronan-binding proteinchondroitin sulfate proteoglycan 7chondroitin sulfate proteoglycan BEHAB
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000285238, ENST00000427699, 
ENST00000510891, ENST00000515707, 
Fusion gene scores* DoF score16 X 12 X 7=13443 X 1 X 2=6
# samples 183
** MAII scorelog2(18/1344*10)=-2.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/6*10)=2.32192809488736
Context

PubMed: ABCC3 [Title/Abstract] AND BCAN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABCC3(48751019)-BCAN(156627467), # samples:3
Anticipated loss of major functional domain due to fusion event.ABCC3-BCAN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC3-BCAN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC3-BCAN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC3-BCAN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABCC3

GO:0042908

xenobiotic transport

18698235|19334674


check buttonFusion gene breakpoints across ABCC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across BCAN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-CW-5584-01AABCC3chr17

48751019

-BCANchr1

156627467

+
ChimerDB4KIRCTCGA-CW-5584-01AABCC3chr17

48751019

+BCANchr1

156627467

+


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Fusion Gene ORF analysis for ABCC3-BCAN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000285238ENST00000361588ABCC3chr17

48751019

+BCANchr1

156627467

+
In-frameENST00000285238ENST00000329117ABCC3chr17

48751019

+BCANchr1

156627467

+
intron-3CDSENST00000427699ENST00000329117ABCC3chr17

48751019

+BCANchr1

156627467

+
intron-3CDSENST00000510891ENST00000329117ABCC3chr17

48751019

+BCANchr1

156627467

+
intron-3CDSENST00000515707ENST00000329117ABCC3chr17

48751019

+BCANchr1

156627467

+
intron-intronENST00000427699ENST00000361588ABCC3chr17

48751019

+BCANchr1

156627467

+
intron-intronENST00000510891ENST00000361588ABCC3chr17

48751019

+BCANchr1

156627467

+
intron-intronENST00000515707ENST00000361588ABCC3chr17

48751019

+BCANchr1

156627467

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000285238ABCC3chr1748751019+ENST00000329117BCANchr1156627467+360026795932051048

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000285238ENST00000329117ABCC3chr1748751019+BCANchr1156627467+0.0019949350.9980051

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Fusion Genomic Features for ABCC3-BCAN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ABCC3chr1748751019+BCANchr1156627466+0.0040412390.99595875
ABCC3chr1748751019+BCANchr1156627466+0.0040412390.99595875

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ABCC3-BCAN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:48751019/chr1:156627467)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+1931311_5948661528.0DomainABC transmembrane type-1 1
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+1931629_8518661528.0DomainABC transporter 1
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+1931661_6688661528.0Nucleotide bindingATP 1
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+1931121_1328661528.0Topological domainCytoplasmic
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+1931154_1718661528.0Topological domainExtracellular
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+1931193_3028661528.0Topological domainCytoplasmic
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+19311_328661528.0Topological domainExtracellular
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+1931324_3498661528.0Topological domainExtracellular
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+1931371_4268661528.0Topological domainCytoplasmic
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+1931448_4508661528.0Topological domainExtracellular
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+1931472_5338661528.0Topological domainCytoplasmic
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+193154_738661528.0Topological domainCytoplasmic
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+1931555_5768661528.0Topological domainExtracellular
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+193195_998661528.0Topological domainExtracellular
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+1931100_1208661528.0TransmembraneHelical%3B Name%3D3
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+1931133_1538661528.0TransmembraneHelical%3B Name%3D4
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+1931172_1928661528.0TransmembraneHelical%3B Name%3D5
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+1931303_3238661528.0TransmembraneHelical%3B Name%3D6
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+193133_538661528.0TransmembraneHelical%3B Name%3D1
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+1931350_3708661528.0TransmembraneHelical%3B Name%3D7
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+1931427_4478661528.0TransmembraneHelical%3B Name%3D8
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+1931451_4718661528.0TransmembraneHelical%3B Name%3D9
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+1931534_5548661528.0TransmembraneHelical%3B Name%3D10
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+1931577_5978661528.0TransmembraneHelical%3B Name%3D11
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+193174_948661528.0TransmembraneHelical%3B Name%3D2
TgeneBCANchr17:48751019chr1:156627467ENST0000036158808385_4770672.0Compositional biasNote=Glu-rich
TgeneBCANchr17:48751019chr1:156627467ENST00000329117914813_873736912.0DomainSushi
TgeneBCANchr17:48751019chr1:156627467ENST0000036158808157_2520672.0DomainLink 1
TgeneBCANchr17:48751019chr1:156627467ENST0000036158808257_3540672.0DomainLink 2
TgeneBCANchr17:48751019chr1:156627467ENST000003615880836_1550672.0DomainNote=Ig-like V-type
TgeneBCANchr17:48751019chr1:156627467ENST0000036158808646_6820672.0DomainEGF-like
TgeneBCANchr17:48751019chr1:156627467ENST0000036158808695_8090672.0DomainC-type lectin
TgeneBCANchr17:48751019chr1:156627467ENST0000036158808813_8730672.0DomainSushi
TgeneBCANchr17:48751019chr1:156627467ENST0000036158808520_5300672.0RegionNote=O-glycosylated at two sites
TgeneBCANchr17:48751019chr1:156627467ENST0000036158808540_5450672.0RegionNote=O-glycosylated at two sites
TgeneBCANchr17:48751019chr1:156627467ENST0000036158808569_5750672.0RegionNote=O-glycosylated at one site

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+19311291_15238661528.0DomainABC transporter 2
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+1931971_12528661528.0DomainABC transmembrane type-1 2
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+1121291_15230573.0DomainABC transporter 2
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+112311_5940573.0DomainABC transmembrane type-1 1
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+112629_8510573.0DomainABC transporter 1
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+112971_12520573.0DomainABC transmembrane type-1 2
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+19311323_13308661528.0Nucleotide bindingATP 2
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+1121323_13300573.0Nucleotide bindingATP 2
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+112661_6680573.0Nucleotide bindingATP 1
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+19311043_10858661528.0Topological domainCytoplasmic
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+19311107_11078661528.0Topological domainExtracellular
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+19311129_11998661528.0Topological domainCytoplasmic
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+19311221_12228661528.0Topological domainExtracellular
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+19311244_15278661528.0Topological domainCytoplasmic
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+1931598_9638661528.0Topological domainCytoplasmic
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+1931985_10218661528.0Topological domainExtracellular
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+1121043_10850573.0Topological domainCytoplasmic
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+1121107_11070573.0Topological domainExtracellular
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+1121129_11990573.0Topological domainCytoplasmic
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+112121_1320573.0Topological domainCytoplasmic
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+1121221_12220573.0Topological domainExtracellular
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+1121244_15270573.0Topological domainCytoplasmic
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+112154_1710573.0Topological domainExtracellular
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+112193_3020573.0Topological domainCytoplasmic
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+1121_320573.0Topological domainExtracellular
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+112324_3490573.0Topological domainExtracellular
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+112371_4260573.0Topological domainCytoplasmic
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+112448_4500573.0Topological domainExtracellular
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+112472_5330573.0Topological domainCytoplasmic
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+11254_730573.0Topological domainCytoplasmic
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+112555_5760573.0Topological domainExtracellular
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+112598_9630573.0Topological domainCytoplasmic
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+11295_990573.0Topological domainExtracellular
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+112985_10210573.0Topological domainExtracellular
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+19311022_10428661528.0TransmembraneHelical%3B Name%3D13
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+19311086_11068661528.0TransmembraneHelical%3B Name%3D14
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+19311108_11288661528.0TransmembraneHelical%3B Name%3D15
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+19311200_12208661528.0TransmembraneHelical%3B Name%3D16
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+19311223_12438661528.0TransmembraneHelical%3B Name%3D17
HgeneABCC3chr17:48751019chr1:156627467ENST00000285238+1931964_9848661528.0TransmembraneHelical%3B Name%3D12
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+112100_1200573.0TransmembraneHelical%3B Name%3D3
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+1121022_10420573.0TransmembraneHelical%3B Name%3D13
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+1121086_11060573.0TransmembraneHelical%3B Name%3D14
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+1121108_11280573.0TransmembraneHelical%3B Name%3D15
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+1121200_12200573.0TransmembraneHelical%3B Name%3D16
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+1121223_12430573.0TransmembraneHelical%3B Name%3D17
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+112133_1530573.0TransmembraneHelical%3B Name%3D4
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+112172_1920573.0TransmembraneHelical%3B Name%3D5
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+112303_3230573.0TransmembraneHelical%3B Name%3D6
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+11233_530573.0TransmembraneHelical%3B Name%3D1
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+112350_3700573.0TransmembraneHelical%3B Name%3D7
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+112427_4470573.0TransmembraneHelical%3B Name%3D8
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+112451_4710573.0TransmembraneHelical%3B Name%3D9
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+112534_5540573.0TransmembraneHelical%3B Name%3D10
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+112577_5970573.0TransmembraneHelical%3B Name%3D11
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+11274_940573.0TransmembraneHelical%3B Name%3D2
HgeneABCC3chr17:48751019chr1:156627467ENST00000427699+112964_9840573.0TransmembraneHelical%3B Name%3D12
TgeneBCANchr17:48751019chr1:156627467ENST00000329117914385_477736912.0Compositional biasNote=Glu-rich
TgeneBCANchr17:48751019chr1:156627467ENST00000329117914157_252736912.0DomainLink 1
TgeneBCANchr17:48751019chr1:156627467ENST00000329117914257_354736912.0DomainLink 2
TgeneBCANchr17:48751019chr1:156627467ENST0000032911791436_155736912.0DomainNote=Ig-like V-type
TgeneBCANchr17:48751019chr1:156627467ENST00000329117914646_682736912.0DomainEGF-like
TgeneBCANchr17:48751019chr1:156627467ENST00000329117914695_809736912.0DomainC-type lectin
TgeneBCANchr17:48751019chr1:156627467ENST00000329117914520_530736912.0RegionNote=O-glycosylated at two sites
TgeneBCANchr17:48751019chr1:156627467ENST00000329117914540_545736912.0RegionNote=O-glycosylated at two sites
TgeneBCANchr17:48751019chr1:156627467ENST00000329117914569_575736912.0RegionNote=O-glycosylated at one site


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Fusion Gene Sequence for ABCC3-BCAN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>252_252_1_ABCC3-BCAN_ABCC3_chr17_48751019_ENST00000285238_BCAN_chr1_156627467_ENST00000329117_length(transcript)=3600nt_BP=2679nt
GCGGAGGCGGCTCCGGCGCCCGCTCTGCCCGCCGCTGGGTCCGACCGCGCTCGCCTTCCTTGCAGCCGCGCCTCGGCCCCATGGACGCCC
TGTGCGGTTCCGGGGAGCTCGGCTCCAAGTTCTGGGACTCCAACCTGTCTGTGCACACAGAAAACCCGGACCTCACTCCCTGCTTCCAGA
ACTCCCTGCTGGCCTGGGTGCCCTGCATCTACCTGTGGGTCGCCCTGCCCTGCTACTTGCTCTACCTGCGGCACCATTGTCGTGGCTACA
TCATCCTCTCCCACCTGTCCAAGCTCAAGATGGTCCTGGGTGTCCTGCTGTGGTGCGTCTCCTGGGCGGACCTTTTTTACTCCTTCCATG
GCCTGGTCCATGGCCGGGCCCCTGCCCCTGTTTTCTTTGTCACCCCCTTGGTGGTGGGGGTCACCATGCTGCTGGCCACCCTGCTGATAC
AGTATGAGCGGCTGCAGGGCGTACAGTCTTCGGGGGTCCTCATTATCTTCTGGTTCCTGTGTGTGGTCTGCGCCATCGTCCCATTCCGCT
CCAAGATCCTTTTAGCCAAGGCAGAGGGTGAGATCTCAGACCCCTTCCGCTTCACCACCTTCTACATCCACTTTGCCCTGGTACTCTCTG
CCCTCATCTTGGCCTGCTTCAGGGAGAAACCTCCATTTTTCTCCGCAAAGAATGTCGACCCTAACCCCTACCCTGAGACCAGCGCTGGCT
TTCTCTCCCGCCTGTTTTTCTGGTGGTTCACAAAGATGGCCATCTATGGCTACCGGCATCCCCTGGAGGAGAAGGACCTCTGGTCCCTAA
AGGAAGAGGACAGATCCCAGATGGTGGTGCAGCAGCTGCTGGAGGCATGGAGGAAGCAGGAAAAGCAGACGGCACGACACAAGGCTTCAG
CAGCACCTGGGAAAAATGCCTCCGGCGAGGACGAGGTGCTGCTGGGTGCCCGGCCCAGGCCCCGGAAGCCCTCCTTCCTGAAGGCCCTGC
TGGCCACCTTCGGCTCCAGCTTCCTCATCAGTGCCTGCTTCAAGCTTATCCAGGACCTGCTCTCCTTCATCAATCCACAGCTGCTCAGCA
TCCTGATCAGGTTTATCTCCAACCCCATGGCCCCCTCCTGGTGGGGCTTCCTGGTGGCTGGGCTGATGTTCCTGTGCTCCATGATGCAGT
CGCTGATCTTACAACACTATTACCACTACATCTTTGTGACTGGGGTGAAGTTTCGTACTGGGATCATGGGTGTCATCTACAGGAAGGCTC
TGGTTATCACCAACTCAGTCAAACGTGCGTCCACTGTGGGGGAAATTGTCAACCTCATGTCAGTGGATGCCCAGCGCTTCATGGACCTTG
CCCCCTTCCTCAATCTGCTGTGGTCAGCACCCCTGCAGATCATCCTGGCGATCTACTTCCTCTGGCAGAACCTAGGTCCCTCTGTCCTGG
CTGGAGTCGCTTTCATGGTCTTGCTGATTCCACTCAACGGAGCTGTGGCCGTGAAGATGCGCGCCTTCCAGGTAAAGCAAATGAAATTGA
AGGACTCGCGCATCAAGCTGATGAGTGAGATCCTGAACGGCATCAAGGTGCTGAAGCTGTACGCCTGGGAGCCCAGCTTCCTGAAGCAGG
TGGAGGGCATCAGGCAGGGTGAGCTCCAGCTGCTGCGCACGGCGGCCTACCTCCACACCACAACCACCTTCACCTGGATGTGCAGCCCCT
TCCTGGTGACCCTGATCACCCTCTGGGTGTACGTGTACGTGGACCCAAACAATGTGCTGGACGCCGAGAAGGCCTTTGTGTCTGTGTCCT
TGTTTAATATCTTAAGACTTCCCCTCAACATGCTGCCCCAGTTAATCAGCAACCTGACTCAGGCCAGTGTGTCTCTGAAACGGATCCAGC
AATTCCTGAGCCAAGAGGAACTTGACCCCCAGAGTGTGGAAAGAAAGACCATCTCCCCAGGCTATGCCATCACCATACACAGTGGCACCT
TCACCTGGGCCCAGGACCTGCCCCCCACTCTGCACAGCCTAGACATCCAGGTCCCGAAAGGGGCACTGGTGGCCGTGGTGGGGCCTGTGG
GCTGTGGGAAGTCCTCCCTGGTGTCTGCCCTGCTGGGAGAGATGGAGAAGCTAGAAGGCAAAGTGCACATGAAGGGCTCCGTGGCCTATG
TGCCCCAGCAGGCATGGATCCAGAACTGCACTCTTCAGGAAAACGTGCTTTTCGGCAAAGCCCTGAACCCCAAGCGCTACCAGCAGACTC
TGGAGGCCTGTGCCTTGCTAGCTGACCTGGAGATGCTGCCTGGTGGGGATCAGACAGAGATTGGAGAGAAGGGCATTAACCTGTCTGGGG
GCCAGCGGCAGCGGGTCAGTCTGGCTCGAGCTGTTTACAGTGATGCCGATATTTTCTTGCTGGATGACCCACTGTCCGCGGTGGACTCTC
ATGTGGCCAAGCACATCTTTGACCACGTCATCGGGCCAGAAGGCGTGCTGGCAGGCAAGACGCGAGTGCTGGTGACGCACGGCATTAGCT
TCCTGCCCCAGACAGACTTCATCATTGTGCTAGCTGATGGACAGGTGTCTGAGATGGGCCCGTACCCAGCCCTGCTGCAGCGCAACGGCT
CCTTTGCCAACTTTCTCTGCAACTATGCCCCCGATGAGGACCAAGGGCACCTGGAGGACAGCTGGACCGACCGGTACCGGGAGTACCAGT
GGATCGGACTCAACGACAGGACCATCGAAGGCGACTTCTTGTGGTCGGATGGCGTCCCCCTGCTCTATGAGAACTGGAACCCTGGGCAGC
CTGACAGCTACTTCCTGTCTGGAGAGAACTGCGTGGTCATGGTGTGGCATGATCAGGGACAATGGAGTGACGTGCCCTGCAACTACCACC
TGTCCTACACCTGCAAGATGGGGCTGGTGTCCTGTGGGCCGCCACCGGAGCTGCCCCTGGCTCAAGTGTTCGGCCGCCCACGGCTGCGCT
ATGAGGTGGACACTGTGCTTCGCTACCGGTGCCGGGAAGGACTGGCCCAGCGCAATCTGCCGCTGATCCGATGCCAAGAGAACGGTCGTT
GGGAGGCCCCCCAGATCTCCTGTGTGCCCAGAAGACCTGCCCGAGCTCTGCACCCAGAGGAGGACCCAGAAGGACGTCAGGGGAGGCTAC
TGGGACGCTGGAAGGCGCTGTTGATCCCCCCTTCCAGCCCCATGCCAGGTCCCTAGGGGGCAAGGCCTTGAACACTGCCGGCCACAGCAC
TGCCCTGTCACCCAAATTTTCCCTCACACCCTGCGCTCCCGCCACCACAGGAAGTGACAACATGACGAGGGGTGGTACTGGAGTCCAGGT
GACAGTTCCTGAAGGGGCTTCTGGGAAATACCTAGGAGGCTCCAGCCCAGCCCAGGCCCTCTCCCCCTACCCTGGGCACCAGATCTTCCA
TCAGGGCCGGAGTAAATCCCTAAGTGCCTCAACTGCCCTCTCCCTGGCAGCCATCTTGTCCCCTCTATTCCTCTAGGGAGCACTGTGCCC
ACTCTTTCTGGGTTTTCCAAGGGAATGGGCTTGCAGGATGGAGTGTCTGTAAAATCAACAGGAAATAAAACTGTGTATGAGCCCAGGCAA

>252_252_1_ABCC3-BCAN_ABCC3_chr17_48751019_ENST00000285238_BCAN_chr1_156627467_ENST00000329117_length(amino acids)=1048AA_BP=873
MQPRLGPMDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIILSHLSKLKMVLGVLLWCV
SWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTT
FYIHFALVLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQ
EKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVA
GLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYF
LWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHT
TTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTISP
GYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGK
ALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGK
TRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTDRYREYQWIGLNDRTIEGDFLWSDGVP
LLYENWNPGQPDSYFLSGENCVVMVWHDQGQWSDVPCNYHLSYTCKMGLVSCGPPPELPLAQVFGRPRLRYEVDTVLRYRCREGLAQRNL

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Fusion Gene PPI Analysis for ABCC3-BCAN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABCC3-BCAN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ABCC3-BCAN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABCC3C0003873Rheumatoid Arthritis1CTD_human
HgeneABCC3C0008370Cholestasis1CTD_human
HgeneABCC3C0009402Colorectal Carcinoma1CTD_human
HgeneABCC3C0009404Colorectal Neoplasms1CTD_human
HgeneABCC3C0019209Hepatomegaly1CTD_human