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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CBR1-ANKRD17 (FusionGDB2 ID:HG873TG26057)

Fusion Gene Summary for CBR1-ANKRD17

check button Fusion gene summary
Fusion gene informationFusion gene name: CBR1-ANKRD17
Fusion gene ID: hg873tg26057
HgeneTgene
Gene symbol

CBR1

ANKRD17

Gene ID

873

26057

Gene namecarbonyl reductase 1ankyrin repeat domain 17
SynonymsCBR|SDR21C1|hCBR1GTAR|MASK2|NY-BR-16
Cytomap('CBR1')('ANKRD17')

21q22.12

4q13.3

Type of geneprotein-codingprotein-coding
Descriptioncarbonyl reductase [NADPH] 115-hydroxyprostaglandin dehydrogenaseNADPH-dependent carbonyl reductase 1carbonyl reductase (NADPH) 1epididymis secretory sperm binding proteinprostaglandin 9-ketoreductaseprostaglandin-E(2) 9-reductaseshort chain dehydrankyrin repeat domain-containing protein 17gene trap ankyrin repeat proteinserologically defined breast cancer antigen NY-BR-16
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000466328, ENST00000290349, 
ENST00000399191, ENST00000439427, 
ENST00000530908, 
Fusion gene scores* DoF score3 X 2 X 1=612 X 18 X 5=1080
# samples 321
** MAII scorelog2(3/6*10)=2.32192809488736log2(21/1080*10)=-2.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CBR1 [Title/Abstract] AND ANKRD17 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCBR1(37443269)-ANKRD17(73956613), # samples:1
Anticipated loss of major functional domain due to fusion event.CBR1-ANKRD17 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CBR1-ANKRD17 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CBR1-ANKRD17 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CBR1-ANKRD17 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CBR1-ANKRD17 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CBR1-ANKRD17 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CBR1-ANKRD17 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCBR1

GO:0017144

drug metabolic process

18449627

HgeneCBR1

GO:0042373

vitamin K metabolic process

18449627

HgeneCBR1

GO:0055114

oxidation-reduction process

19442656

TgeneANKRD17

GO:0042742

defense response to bacterium

23711367

TgeneANKRD17

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

22328336

TgeneANKRD17

GO:0045087

innate immune response

23711367

TgeneANKRD17

GO:1900245

positive regulation of MDA-5 signaling pathway

22328336

TgeneANKRD17

GO:1900246

positive regulation of RIG-I signaling pathway

22328336


check buttonFusion gene breakpoints across CBR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ANKRD17 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for CBR1-ANKRD17

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000439427ENST00000358602CBR1chr2137443269+ANKRD17chr473956613-0.508377970.49162203
ENST00000439427ENST00000509867CBR1chr2137443269+ANKRD17chr473956613-0.227744740.77225524
ENST00000439427ENST00000330838CBR1chr2137443269+ANKRD17chr473956613-0.227744740.77225524

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Fusion Genomic Features for CBR1-ANKRD17


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CBR1-ANKRD17


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:37443269/chr4:73956613)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneANKRD17chr21:37443269chr4:73956613ENST000003308380331442_152602353.0Coiled coilOntology_term=ECO:0000255
TgeneANKRD17chr21:37443269chr4:73956613ENST000003586020341442_152602604.0Coiled coilOntology_term=ECO:0000255
TgeneANKRD17chr21:37443269chr4:73956613ENST000003308380331603_170002353.0Compositional biasNote=Ser-rich
TgeneANKRD17chr21:37443269chr4:73956613ENST000003308380331950_210602353.0Compositional biasNote=Ser-rich
TgeneANKRD17chr21:37443269chr4:73956613ENST000003308380331966_203302353.0Compositional biasNote=Thr-rich
TgeneANKRD17chr21:37443269chr4:73956613ENST00000330838033858_100802353.0Compositional biasNote=Gln-rich
TgeneANKRD17chr21:37443269chr4:73956613ENST0000033083803396_11002353.0Compositional biasNote=Gly-rich
TgeneANKRD17chr21:37443269chr4:73956613ENST000003586020341603_170002604.0Compositional biasNote=Ser-rich
TgeneANKRD17chr21:37443269chr4:73956613ENST000003586020341950_210602604.0Compositional biasNote=Ser-rich
TgeneANKRD17chr21:37443269chr4:73956613ENST000003586020341966_203302604.0Compositional biasNote=Thr-rich
TgeneANKRD17chr21:37443269chr4:73956613ENST00000358602034858_100802604.0Compositional biasNote=Gln-rich
TgeneANKRD17chr21:37443269chr4:73956613ENST0000035860203496_11002604.0Compositional biasNote=Gly-rich
TgeneANKRD17chr21:37443269chr4:73956613ENST000003308380331725_178902353.0DomainKH
TgeneANKRD17chr21:37443269chr4:73956613ENST000003586020341725_178902604.0DomainKH
TgeneANKRD17chr21:37443269chr4:73956613ENST000003308380331082_111102353.0RepeatNote=ANK 16
TgeneANKRD17chr21:37443269chr4:73956613ENST000003308380331115_114402353.0RepeatNote=ANK 17
TgeneANKRD17chr21:37443269chr4:73956613ENST000003308380331149_117802353.0RepeatNote=ANK 18
TgeneANKRD17chr21:37443269chr4:73956613ENST000003308380331182_121102353.0RepeatNote=ANK 19
TgeneANKRD17chr21:37443269chr4:73956613ENST000003308380331217_124602353.0RepeatNote=ANK 20
TgeneANKRD17chr21:37443269chr4:73956613ENST000003308380331251_128002353.0RepeatNote=ANK 21
TgeneANKRD17chr21:37443269chr4:73956613ENST000003308380331284_131302353.0RepeatNote=ANK 22
TgeneANKRD17chr21:37443269chr4:73956613ENST000003308380331319_134802353.0RepeatNote=ANK 23
TgeneANKRD17chr21:37443269chr4:73956613ENST000003308380331352_138102353.0RepeatNote=ANK 24
TgeneANKRD17chr21:37443269chr4:73956613ENST000003308380331385_141402353.0RepeatNote=ANK 25
TgeneANKRD17chr21:37443269chr4:73956613ENST00000330838033233_26202353.0RepeatNote=ANK 1
TgeneANKRD17chr21:37443269chr4:73956613ENST00000330838033266_29502353.0RepeatNote=ANK 2
TgeneANKRD17chr21:37443269chr4:73956613ENST00000330838033300_32902353.0RepeatNote=ANK 3
TgeneANKRD17chr21:37443269chr4:73956613ENST00000330838033333_36202353.0RepeatNote=ANK 4
TgeneANKRD17chr21:37443269chr4:73956613ENST00000330838033366_39502353.0RepeatNote=ANK 5
TgeneANKRD17chr21:37443269chr4:73956613ENST00000330838033400_42902353.0RepeatNote=ANK 6
TgeneANKRD17chr21:37443269chr4:73956613ENST00000330838033433_46202353.0RepeatNote=ANK 7
TgeneANKRD17chr21:37443269chr4:73956613ENST00000330838033466_49502353.0RepeatNote=ANK 8
TgeneANKRD17chr21:37443269chr4:73956613ENST00000330838033499_52802353.0RepeatNote=ANK 9
TgeneANKRD17chr21:37443269chr4:73956613ENST00000330838033533_56202353.0RepeatNote=ANK 10
TgeneANKRD17chr21:37443269chr4:73956613ENST00000330838033563_59202353.0RepeatNote=ANK 11
TgeneANKRD17chr21:37443269chr4:73956613ENST00000330838033596_62502353.0RepeatNote=ANK 12
TgeneANKRD17chr21:37443269chr4:73956613ENST00000330838033629_65802353.0RepeatNote=ANK 13
TgeneANKRD17chr21:37443269chr4:73956613ENST00000330838033663_69202353.0RepeatNote=ANK 14
TgeneANKRD17chr21:37443269chr4:73956613ENST00000330838033696_72502353.0RepeatNote=ANK 15
TgeneANKRD17chr21:37443269chr4:73956613ENST000003586020341082_111102604.0RepeatNote=ANK 16
TgeneANKRD17chr21:37443269chr4:73956613ENST000003586020341115_114402604.0RepeatNote=ANK 17
TgeneANKRD17chr21:37443269chr4:73956613ENST000003586020341149_117802604.0RepeatNote=ANK 18
TgeneANKRD17chr21:37443269chr4:73956613ENST000003586020341182_121102604.0RepeatNote=ANK 19
TgeneANKRD17chr21:37443269chr4:73956613ENST000003586020341217_124602604.0RepeatNote=ANK 20
TgeneANKRD17chr21:37443269chr4:73956613ENST000003586020341251_128002604.0RepeatNote=ANK 21
TgeneANKRD17chr21:37443269chr4:73956613ENST000003586020341284_131302604.0RepeatNote=ANK 22
TgeneANKRD17chr21:37443269chr4:73956613ENST000003586020341319_134802604.0RepeatNote=ANK 23
TgeneANKRD17chr21:37443269chr4:73956613ENST000003586020341352_138102604.0RepeatNote=ANK 24
TgeneANKRD17chr21:37443269chr4:73956613ENST000003586020341385_141402604.0RepeatNote=ANK 25
TgeneANKRD17chr21:37443269chr4:73956613ENST00000358602034233_26202604.0RepeatNote=ANK 1
TgeneANKRD17chr21:37443269chr4:73956613ENST00000358602034266_29502604.0RepeatNote=ANK 2
TgeneANKRD17chr21:37443269chr4:73956613ENST00000358602034300_32902604.0RepeatNote=ANK 3
TgeneANKRD17chr21:37443269chr4:73956613ENST00000358602034333_36202604.0RepeatNote=ANK 4
TgeneANKRD17chr21:37443269chr4:73956613ENST00000358602034366_39502604.0RepeatNote=ANK 5
TgeneANKRD17chr21:37443269chr4:73956613ENST00000358602034400_42902604.0RepeatNote=ANK 6
TgeneANKRD17chr21:37443269chr4:73956613ENST00000358602034433_46202604.0RepeatNote=ANK 7
TgeneANKRD17chr21:37443269chr4:73956613ENST00000358602034466_49502604.0RepeatNote=ANK 8
TgeneANKRD17chr21:37443269chr4:73956613ENST00000358602034499_52802604.0RepeatNote=ANK 9
TgeneANKRD17chr21:37443269chr4:73956613ENST00000358602034533_56202604.0RepeatNote=ANK 10
TgeneANKRD17chr21:37443269chr4:73956613ENST00000358602034563_59202604.0RepeatNote=ANK 11
TgeneANKRD17chr21:37443269chr4:73956613ENST00000358602034596_62502604.0RepeatNote=ANK 12
TgeneANKRD17chr21:37443269chr4:73956613ENST00000358602034629_65802604.0RepeatNote=ANK 13
TgeneANKRD17chr21:37443269chr4:73956613ENST00000358602034663_69202604.0RepeatNote=ANK 14
TgeneANKRD17chr21:37443269chr4:73956613ENST00000358602034696_72502604.0RepeatNote=ANK 15

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCBR1chr21:37443269chr4:73956613ENST00000290349+1310_340278.0Nucleotide bindingNADP
HgeneCBR1chr21:37443269chr4:73956613ENST00000290349+13194_1980278.0Nucleotide bindingNADP
HgeneCBR1chr21:37443269chr4:73956613ENST00000290349+13231_2330278.0Nucleotide bindingNADP
HgeneCBR1chr21:37443269chr4:73956613ENST00000290349+1363_640278.0Nucleotide bindingNADP
HgeneCBR1chr21:37443269chr4:73956613ENST00000290349+13193_1940278.0RegionNote=Glutathione binding
HgeneCBR1chr21:37443269chr4:73956613ENST00000290349+1395_970278.0RegionNote=Glutathione binding


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Fusion Gene Sequence for CBR1-ANKRD17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>13410_13410_1_CBR1-ANKRD17_CBR1_chr21_37443269_ENST00000439427_ANKRD17_chr4_73956613_ENST00000330838_length(transcript)=2628nt_BP=1002nt
ACGACCGCCAGACTCGAGCAGTCTCTGGAACACGCTGCGGGGCTCCCGGGCCTGAGCCAGGTCTGTTCTCCACGCAGGTGTTCCGCGCGC
CCCGTTCAGCCATGTCGTCCGGCATCCATGTAGCGCTGGTGACTGGAGGCAACAAGGGCATCGGCTTGGCCATCGTGCGCGACCTGTGCC
GGCTGTTCTCGGGGGACGTGGTGCTCACGGCGCGGGACGTGACGCGGGGCCAGGCGGCCGTACAGCAGCTGCAGGCGGAGGGCCTGAGCC
CGCGCTTCCACCAGCTGGACATCGACGATCTGCAGAGCATCCGCGCCCTGCGCGACTTCCTGCGCAAGGAGTACGGGGGCCTGGACGTGC
TGGTCAACAACGCGGGCATCGCCTTCAAGGTATTCAAGCTGAAGTGACGATGAAAACAAATTTCTTTGGTACCCGAGATGTGTGCACAGA
ATTACTCCCTCTAATAAAACCCCAAGGTGAGTCTGATGGGAAACAGCGCACCTTCTCTTTGGGGCTTGATTTGGCCCCTGCTTGCCTGGG
ATTTCTCCTGCAGGCTCCTGCTTCCTCTCCATGCTGCACGTGCACTGACCTCTGTGCTTTTTCTCCTGCCAGCTGATATGTGCCATTTTG
CCTCAGGACTTTGTCCTCACTTCTCCCACTCCCATGGCCATTCGTCCTCCCTGTCGCACTGGTCTTTGCACACCTGGCTGACTCTCATCC
TTCAGGTCTTAGCTCAAACGTCTCCTGAGAGATGCTCTTTATTTGCTCCATTCCCCTCTGCGTGGGAGTCCATCCTGTACCCTTTCTCTG
CTCTTTCAGAGAGATCTTATTCAGGCTGGTGGAGGCTTTACTACCACCAGTTCATTAGGCCCTTCTAATACCTGTCACCTGTCTGAAACA
CTCCTTAAGCTCCCAACCACATGGTTGTCTTGCTGCCTTTCCATCTCTTCCTGATGCCTTTCCCCACAATCTAAGATATTTCCAGAGGAT
CCCTATCCTTTTGTGTGGACTGGACCCTGGGCACCTCACATGAACAGTGTGCATATGAACCAGCTTGGCTGATGAGGATCAGCTTGTTAG
CCTGCAGATTCCTTTTCATTTGGAGGAAATCACAAGTGGCCGAAAAAAAAAATTATGCTCCCAAATCATTCTACTGATGTGCTTGACTGA
AGTGTGTAGGCTTTTTGCAGAAGATCTTACTAACTGACCTATTTTCTGTGAACATTTGTGACTGCCCATTCCCCATCATCATCCGTTTTA
CCTTAGTTAGCATTTTTCTTATCATTTTTCTTTTTTTCTTTCCCTCTTCCCCTTTGGACATAACTTTCTGTTGAAGCTGTTCTTTGGCTG
GTTGGTTTTAGTACTGTAAACTGCTTCTGAGCAAACACGGAAATTTAGCAAAATTATGTAAACTTGATCCTGAAGTTTTAGAATGGCAAA
TAAATGTACAATTGTTTACATAACAGAAAAGGCTAAGCAGAAAGTAAATTTCAATATGTCAGTATAGAGGCTCTACTTTATGTAGACTTA
AATTAATGTGAGATATGTACCTTCATATTCAGAAATCTGGATGTTTCCTTCATACATTAAACTATTAATAAGCATAAGGTATGCCTTTTT
CTGTGTATGGGAATGCAATGATTCCTCCAGTAGCACCTATCCCTGATGGTGCTGGAGGACCCATATTTAATGGCCCTCATGCTGCAGACC
CTTCTTGGAACTCACTGATAAAGATGGTTTCCAGCTCCACGGAAAATAATGGCCCTCAAACGACAAAGTAGACTGGTGTAACCCTGGGAT
GGGAAATCCTATGATCCACAGACCGATGTCTGACCCAGGAGTATTTTCACAACATCAAGCAATGGAGCGAGATAGTACAGGAATTGTAAC
TCCTTCTGGTACATTCCATCAGCATGTTCCTGCAGGCTACATGGACTTTCCTAAAGTTGGGATTCTTCTGCACAGTCAGTATCCTCGGGA
GTTCGTGCACCATCTCCTGCCCCATCATCAGTACCGTTAGGGTCAGAAAAGCCCAGCAATGTGTCTCAGGACAGGAAAGTTCCAGTCCCT
ATTGGGACTGAACGTTCTGCACGTATCAGGCAAACTGGAACGTCAGCTCCATCTGTTATTGGGAGCAATTTGTCTACATCAGTAGGACAT
AGTGGCATCTGGTCCTTTGAAGGGATTGGTGGCAATCAAGGTATTGTCAATATGGACTCGCCATATGGTTCTGTAACACCTTCTTCAACA
CATTTGGGAAACTTTGCTTCAAACATTTCAGGAGGTCAGATGTACGGACCTGGGGCACCCCTTGGAGGAGCACCCGCAGCTGCTAACTTT
AACAGACAACATTTTTCCCCGCTTAGTTTGTTGACTCCGTGTTCATCAGCATCAAATGTTTCAGTGCCCCCTTACCATTTGGGCCCTTTA
GCACATTGTTTGAAAACAGCCCTACTTCTGCTCATGCCTTCTGGGGAGGATCTGTTGTTTCATCTCAGTCAACACCAGAATCTATGCTAT
CAGGAAAATCCTCATATTTGCCAAATTCAGATCCTTTACATCAGTCTGATACTTCCAAAGCTCCAGGTTTTAGACCACCATTACAGAGAC

>13410_13410_1_CBR1-ANKRD17_CBR1_chr21_37443269_ENST00000439427_ANKRD17_chr4_73956613_ENST00000330838_length(amino acids)=176AA_BP=
MAHISWQEKKHRGQCTCSMERKQEPAGEIPGKQGPNQAPKRRCAVSHQTHLGVLLEGVILCTHLGYQRNLFSSSLQLEYLEGDARVVDQH

--------------------------------------------------------------
>13410_13410_2_CBR1-ANKRD17_CBR1_chr21_37443269_ENST00000439427_ANKRD17_chr4_73956613_ENST00000358602_length(transcript)=4938nt_BP=1002nt
ACGACCGCCAGACTCGAGCAGTCTCTGGAACACGCTGCGGGGCTCCCGGGCCTGAGCCAGGTCTGTTCTCCACGCAGGTGTTCCGCGCGC
CCCGTTCAGCCATGTCGTCCGGCATCCATGTAGCGCTGGTGACTGGAGGCAACAAGGGCATCGGCTTGGCCATCGTGCGCGACCTGTGCC
GGCTGTTCTCGGGGGACGTGGTGCTCACGGCGCGGGACGTGACGCGGGGCCAGGCGGCCGTACAGCAGCTGCAGGCGGAGGGCCTGAGCC
CGCGCTTCCACCAGCTGGACATCGACGATCTGCAGAGCATCCGCGCCCTGCGCGACTTCCTGCGCAAGGAGTACGGGGGCCTGGACGTGC
TGGTCAACAACGCGGGCATCGCCTTCAAGGTATTCAAGCTGAAGTGACGATGAAAACAAATTTCTTTGGTACCCGAGATGTGTGCACAGA
ATTACTCCCTCTAATAAAACCCCAAGGTGAGTCTGATGGGAAACAGCGCACCTTCTCTTTGGGGCTTGATTTGGCCCCTGCTTGCCTGGG
ATTTCTCCTGCAGGCTCCTGCTTCCTCTCCATGCTGCACGTGCACTGACCTCTGTGCTTTTTCTCCTGCCAGCTGATATGTGCCATTTTG
CCTCAGGACTTTGTCCTCACTTCTCCCACTCCCATGGCCATTCGTCCTCCCTGTCGCACTGGTCTTTGCACACCTGGCTGACTCTCATCC
TTCAGGTCTTAGCTCAAACGTCTCCTGAGAGATGCTCTTTATTTGCTCCATTCCCCTCTGCGTGGGAGTCCATCCTGTACCCTTTCTCTG
CTCTTTCAGAGAGATCTTATTCAGGCTGGTGGAGGCTTTACTACCACCAGTTCATTAGGCCCTTCTAATACCTGTCACCTGTCTGAAACA
CTCCTTAAGCTCCCAACCACATGGTTGTCTTGCTGCCTTTCCATCTCTTCCTGATGCCTTTCCCCACAATCTAAGATATTTCCAGAGGAT
CCCTATCCTTTTGTGTGGACTGGACCCTGGGCACCTCACATGAACAGTGTGCATATGAACCAGCTTGGCTGATGAGGATCAGCTTGTTAG
CCTGCAGATTCCTTTTCATTTGGAGGAAATCACAAGTGGCCGAAAAAAAAAATTATGCTCCCAAATCATTCTACTGATGTGCTTGACTGA
AGTGTGTAGGCTTTTTGCAGAAGATCTTACTAACTGACCTATTTTCTGTGAACATTTGTGACTGCCCATTCCCCATCATCATCCGTTTTA
CCTTAGTTAGCATTTTTCTTATCATTTTTCTTTTTTTCTTTCCCTCTTCCCCTTTGGACATAACTTTCTGTTGAAGCTGTTCTTTGGCTG
GTTGGTTTTAGTACTGTAAACTGCTTCTGAGCAAACACGGAAATTTAGCAAAATTATGTAAACTTGATCCTGAAGTTTTAGAATGGCAAA
TAAATGTACAATTGTTTACATAACAGAAAAGGCTAAGCAGAAAGTAAATTTCAATATGTCAGTATAGAGGCTCTACTTTATGTAGACTTA
AATTAATGTGAGATATGTACCTTCATATTCAGAAATCTGGATGTTTCCTTCATACATTAAACTATTAATAAGCATAACTTTTCTACTGGT
GTAATTTAAGTATAAAGTAAAATAATGGGCATTATCATTGGATGTTTCCCCACATTGGCTTTTAAAATACCCATCTTGCTTTCTTTTTGG
TTTATTTGTAGCAAGGCACATATAGAAGAAGAAATTTCTGGCTTTTCCATGTTGTTTTATTACCTTTTCTCACTTTTAAAACTAATACAG
ACTTATCTCCTCACTCCTTTTTCTCTCCTTACCTTTACCACTAATACCAGTAAAATTATCTTTCTGATAGTGAAAAGGTTCTGTCAAGAT
TTTCACTGTAATGGCTGCTACAGAGATGGACCATCTTCATCATCACCAGTGGTTTCTTCTAATTATAAAATGTTTAAACTTTCTGAGAAT
TTAAAAAGCCACCACTGTTCCCAGTCAGCATATACAAGCTCTTAATATTCTGTTTATTAAATAATTCAATGTACTATTTTATATTGGATG
ATATTGATTCTTAACATTGGCTTTTCAGTCATCAACAGTCAACATAAAAATTTCAATTTTCAGTAATTTAGTGGAAAATATCTTATTTCT
TTTTTCAATTTTAAAGGCTTCCTGCTTTTTTACCCTTGTATATTATCAGTGAAAAGGATCAACAGTTAATTTGAGCCAAGTAATAAAAGA
AATTCTGCATTTGTCACGAAGACAATTTATGGTAGACAGATAAATACACAGATTACAGTGTAAAGTCTCCATTTAACCTGTTTATAAAAG
ATACAAGGCCACACTAAACTACTCAGTGGGATTTATATATTCCATCCACTTGAAACAATAAACAGTAATGTATCCAAGAAGATTATGTGT
CCTACCCTGTCTCATGGAAAAATTAATTATATGGTTGAAATGTAAAAGAAAGTAAGCATAAAAATCGAGTAATGTATATATCAATTTGTC
TTCTTTTTTTTTAATTAGACATAAAATTTCACACTGGTAAAACATAAAAACTAACTAAAATTCATATAAATCACCTAGAGTTGATGATAT
TAACATGGTTCCTTGGTTGTCAAGTAAATCAAATGATTTCTTCCATCTGAGTAAAGAGTAAAGCCTGAGTAAAGAGTAAAAAGATGACTT
CTCAAACATATCCAGAAATTTGTAAACAGTACACTCATATCTTTTAGTTTAAGAAGTGGTCTTAAAATATATAAATTTGTTTTTCCACCT
ATGTTTAATATGCCCAAATTTAAAGGGAGAGCTAAAAGACAGCCTACAAATAAATATAGCTATGAAATAAAATTATAGCACTTTACTAAA
AAAGGGATGTAATAATGTTATTTAACGAAGTATTTTATATATGACTTGCCACTATTCTATACATAAAATTTTTTTTCTTAATTCTTTCCT
GTGTTAACTAGGGTTATTTTCTATTTAAGGTAATCCTGCTGGAGAACAGATGCTATCCAATATTTATTACAACACATGAGTTGTGTTGTT
TCACAATACTGAATTTCTTAGGTGAGGTATTTTATTTAAAAAGGAGGGGGAAAACTCCTATATTTTCTTGACTTCAAACCTGTGGGGCCA
GGGGATATAGATTGAAATGCTCCGTATTTAGTCTTGGGGATCAGGCTTGTTTAGTACAATACCATGGTTTTAGAAGTCTGTACTAGGAAC
ATTTTTAAAATACATTTTTTATATTTCAGATGTAATGCAGTGCACTTTTATTTGAACAATAAAAAAACCCATAACTTTTTGAGACCATGA
AGGTCTTTTATTTTTTAATTTTGAAAATATGTGGTATGTGTATATGCAGACTACATCATTGTTTTAAGAAATGATTTAACTCTTGGACAT
TACACTTGGGTTAGTTCACACCTTAAATCCCCAAGTAGTTAATATCTCAATTATTGTATAATCAGTTTATACCATCCATTCCCAACAAAA
TTCCACATTTCATGCCTTTTCAACATACATTTCAACATAATCAACATATTTACAAACACTGACTTCACTGTTTATAAAGAAGAAATTTCC
CCTCCTATTTCCCATTACTGAAAAGTCAAGTCATTTTTATTGATACATGAAAATTAATTTTTTTGTAAATGACTACGTATAGTCATTTTT
CTCCTTTGGAAAAGGTAAATAGCTTATTAACTAATCCTGTCTTGTTCTTCACAAAAATAATAGTCCATCCGTGTTTTGACTCAAATAACC
TAAATACACATTTTGTAAAAATTTTGTACCCTATATTACTTATTTTTAAAACAGTACAGTGTTAGACTAAACAGGAAAACTCAAAGTTAT
AAAATCTCTTCAGATCCTCTAGTTTATTAAATCTATTTTCATGTTGAGGTATGCCTTTTTCTGTGTATGGGAATGCAATGATTCCTCCAG
TAGCACCTATCCCTGATGGTGCTGGAGGACCCATATTTAATGGCCCTCATGCTGCAGACCCTTCTTGGAACTCACTGATAAAGATGGTTT
CCAGCTCCACGGAAAATAATGGCCCTCAAACGACAAAGTAGACTGGTGTAACCCTGGGATGGGAAATCCTATGATCCACAGACCGATGTC
TGACCCAGGAGTATTTTCACAACATCAAGCAATGGAGCGAGATAGTACAGGAATTGTAACTCCTTCTGGTACATTCCATCAGCATGTTCC
TGCAGGCTACATGGACTTTCCTAAAGTTGGGATTCTTCTGCACAGTCAGTATCCTCGGGAGTTCGTGCACCATCTCCTGCCCCATCATCA
GTACCGTTAGGGTCAGAAAAGCCCAGCAATGTGTCTCAGGACAGGAAAGTTCCAGTCCCTATTGGGACTGAACGTTCTGCACGTATCAGG
CAAACTGGAACGTCAGCTCCATCTGTTATTGGGAGCAATTTGTCTACATCAGTAGGACATAGTGGCATCTGGTCCTTTGAAGGGATTGGT
GGCAATCAAGGTATTGTCAATATGGACTCGCCATATGGTTCTGTAACACCTTCTTCAACACATTTGGGAAACTTTGCTTCAAACATTTCA
GGAGGTCAGATGTACGGACCTGGGGCACCCCTTGGAGGAGCACCCGCAGCTGCTAACTTTAACAGACAACATTTTTCCCCGCTTAGTTTG
TTGACTCCGTGTTCATCAGCATCAAATGTTTCAGTGCCCCCTTACCATTTGGGCCCTTTAGCACATTGTTTGAAAACAGCCCTACTTCTG
CTCATGCCTTCTGGGGAGGATCTGTTGTTTCATCTCAGTCAACACCAGAATCTATGCTATCAGGAAAATCCTCATATTTGCCAAATTCAG

>13410_13410_2_CBR1-ANKRD17_CBR1_chr21_37443269_ENST00000439427_ANKRD17_chr4_73956613_ENST00000358602_length(amino acids)=176AA_BP=
MAHISWQEKKHRGQCTCSMERKQEPAGEIPGKQGPNQAPKRRCAVSHQTHLGVLLEGVILCTHLGYQRNLFSSSLQLEYLEGDARVVDQH

--------------------------------------------------------------
>13410_13410_3_CBR1-ANKRD17_CBR1_chr21_37443269_ENST00000439427_ANKRD17_chr4_73956613_ENST00000509867_length(transcript)=2628nt_BP=1002nt
ACGACCGCCAGACTCGAGCAGTCTCTGGAACACGCTGCGGGGCTCCCGGGCCTGAGCCAGGTCTGTTCTCCACGCAGGTGTTCCGCGCGC
CCCGTTCAGCCATGTCGTCCGGCATCCATGTAGCGCTGGTGACTGGAGGCAACAAGGGCATCGGCTTGGCCATCGTGCGCGACCTGTGCC
GGCTGTTCTCGGGGGACGTGGTGCTCACGGCGCGGGACGTGACGCGGGGCCAGGCGGCCGTACAGCAGCTGCAGGCGGAGGGCCTGAGCC
CGCGCTTCCACCAGCTGGACATCGACGATCTGCAGAGCATCCGCGCCCTGCGCGACTTCCTGCGCAAGGAGTACGGGGGCCTGGACGTGC
TGGTCAACAACGCGGGCATCGCCTTCAAGGTATTCAAGCTGAAGTGACGATGAAAACAAATTTCTTTGGTACCCGAGATGTGTGCACAGA
ATTACTCCCTCTAATAAAACCCCAAGGTGAGTCTGATGGGAAACAGCGCACCTTCTCTTTGGGGCTTGATTTGGCCCCTGCTTGCCTGGG
ATTTCTCCTGCAGGCTCCTGCTTCCTCTCCATGCTGCACGTGCACTGACCTCTGTGCTTTTTCTCCTGCCAGCTGATATGTGCCATTTTG
CCTCAGGACTTTGTCCTCACTTCTCCCACTCCCATGGCCATTCGTCCTCCCTGTCGCACTGGTCTTTGCACACCTGGCTGACTCTCATCC
TTCAGGTCTTAGCTCAAACGTCTCCTGAGAGATGCTCTTTATTTGCTCCATTCCCCTCTGCGTGGGAGTCCATCCTGTACCCTTTCTCTG
CTCTTTCAGAGAGATCTTATTCAGGCTGGTGGAGGCTTTACTACCACCAGTTCATTAGGCCCTTCTAATACCTGTCACCTGTCTGAAACA
CTCCTTAAGCTCCCAACCACATGGTTGTCTTGCTGCCTTTCCATCTCTTCCTGATGCCTTTCCCCACAATCTAAGATATTTCCAGAGGAT
CCCTATCCTTTTGTGTGGACTGGACCCTGGGCACCTCACATGAACAGTGTGCATATGAACCAGCTTGGCTGATGAGGATCAGCTTGTTAG
CCTGCAGATTCCTTTTCATTTGGAGGAAATCACAAGTGGCCGAAAAAAAAAATTATGCTCCCAAATCATTCTACTGATGTGCTTGACTGA
AGTGTGTAGGCTTTTTGCAGAAGATCTTACTAACTGACCTATTTTCTGTGAACATTTGTGACTGCCCATTCCCCATCATCATCCGTTTTA
CCTTAGTTAGCATTTTTCTTATCATTTTTCTTTTTTTCTTTCCCTCTTCCCCTTTGGACATAACTTTCTGTTGAAGCTGTTCTTTGGCTG
GTTGGTTTTAGTACTGTAAACTGCTTCTGAGCAAACACGGAAATTTAGCAAAATTATGTAAACTTGATCCTGAAGTTTTAGAATGGCAAA
TAAATGTACAATTGTTTACATAACAGAAAAGGCTAAGCAGAAAGTAAATTTCAATATGTCAGTATAGAGGCTCTACTTTATGTAGACTTA
AATTAATGTGAGATATGTACCTTCATATTCAGAAATCTGGATGTTTCCTTCATACATTAAACTATTAATAAGCATAAGGTATGCCTTTTT
CTGTGTATGGGAATGCAATGATTCCTCCAGTAGCACCTATCCCTGATGGTGCTGGAGGACCCATATTTAATGGCCCTCATGCTGCAGACC
CTTCTTGGAACTCACTGATAAAGATGGTTTCCAGCTCCACGGAAAATAATGGCCCTCAAACGACAAAGTAGACTGGTGTAACCCTGGGAT
GGGAAATCCTATGATCCACAGACCGATGTCTGACCCAGGAGTATTTTCACAACATCAAGCAATGGAGCGAGATAGTACAGGAATTGTAAC
TCCTTCTGGTACATTCCATCAGCATGTTCCTGCAGGCTACATGGACTTTCCTAAAGTTGGGATTCTTCTGCACAGTCAGTATCCTCGGGA
GTTCGTGCACCATCTCCTGCCCCATCATCAGTACCGTTAGGGTCAGAAAAGCCCAGCAATGTGTCTCAGGACAGGAAAGTTCCAGTCCCT
ATTGGGACTGAACGTTCTGCACGTATCAGGCAAACTGGAACGTCAGCTCCATCTGTTATTGGGAGCAATTTGTCTACATCAGTAGGACAT
AGTGGCATCTGGTCCTTTGAAGGGATTGGTGGCAATCAAGGTATTGTCAATATGGACTCGCCATATGGTTCTGTAACACCTTCTTCAACA
CATTTGGGAAACTTTGCTTCAAACATTTCAGGAGGTCAGATGTACGGACCTGGGGCACCCCTTGGAGGAGCACCCGCAGCTGCTAACTTT
AACAGACAACATTTTTCCCCGCTTAGTTTGTTGACTCCGTGTTCATCAGCATCAAATGTTTCAGTGCCCCCTTACCATTTGGGCCCTTTA
GCACATTGTTTGAAAACAGCCCTACTTCTGCTCATGCCTTCTGGGGAGGATCTGTTGTTTCATCTCAGTCAACACCAGAATCTATGCTAT
CAGGAAAATCCTCATATTTGCCAAATTCAGATCCTTTACATCAGTCTGATACTTCCAAAGCTCCAGGTTTTAGACCACCATTACAGAGAC

>13410_13410_3_CBR1-ANKRD17_CBR1_chr21_37443269_ENST00000439427_ANKRD17_chr4_73956613_ENST00000509867_length(amino acids)=176AA_BP=
MAHISWQEKKHRGQCTCSMERKQEPAGEIPGKQGPNQAPKRRCAVSHQTHLGVLLEGVILCTHLGYQRNLFSSSLQLEYLEGDARVVDQH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CBR1-ANKRD17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CBR1-ANKRD17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CBR1-ANKRD17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCBR1C0007102Malignant tumor of colon1CTD_human
HgeneCBR1C0009375Colonic Neoplasms1CTD_human
HgeneCBR1C0022661Kidney Failure, Chronic1CTD_human
HgeneCBR1C0033141Cardiomyopathies, Primary1CTD_human
HgeneCBR1C0033578Prostatic Neoplasms1CTD_human
HgeneCBR1C0036529Myocardial Diseases, Secondary1CTD_human
HgeneCBR1C0162823Dermatitis, Irritant1CTD_human
HgeneCBR1C0376358Malignant neoplasm of prostate1CTD_human
HgeneCBR1C0878544Cardiomyopathies1CTD_human
HgeneCBR1C2239176Liver carcinoma1CTD_human