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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ADAM15-GALE (FusionGDB2 ID:HG8751TG2582) |
Fusion Gene Summary for ADAM15-GALE |
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Fusion gene information | Fusion gene name: ADAM15-GALE | Fusion gene ID: hg8751tg2582 | Hgene | Tgene | Gene symbol | ADAM15 | GALE | Gene ID | 8751 | 2582 |
Gene name | ADAM metallopeptidase domain 15 | UDP-galactose-4-epimerase | |
Synonyms | MDC15 | SDR1E1 | |
Cytomap | ('ADAM15')('GALE') 1q21.3 | 1p36.11 | |
Type of gene | protein-coding | protein-coding | |
Description | disintegrin and metalloproteinase domain-containing protein 15MDC-15a disintegrin and metalloproteinase domain 15 (metargidin)metalloprotease RGD disintegrin proteinmetalloproteinase-like, disintegrin-like, and cysteine-rich protein 15 | UDP-glucose 4-epimeraseUDP galactose-4'-epimeraseUDP-GalNAc 4-epimeraseUDP-GlcNAc 4-epimeraseUDP-N-acetylgalactosamine 4-epimeraseUDP-N-acetylglucosamine 4-epimeraseepididymis secretory sperm binding proteingalactose-4-epimerase, UDP-galactowalden | |
Modification date | 20200320 | 20200320 | |
UniProtAcc | . | Q14376 | |
Ensembl transtripts involved in fusion gene | ENST00000472434, ENST00000271836, ENST00000355956, ENST00000356955, ENST00000359280, ENST00000368410, ENST00000368413, ENST00000449910, ENST00000531455, ENST00000360674, ENST00000368412, ENST00000447332, | ||
Fusion gene scores | * DoF score | 6 X 6 X 5=180 | 1 X 1 X 1=1 |
# samples | 7 | 1 | |
** MAII score | log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: ADAM15 [Title/Abstract] AND GALE [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ADAM15(155033308)-GALE(24125926), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ADAM15 | GO:0002418 | immune response to tumor cell | 22505472 |
Hgene | ADAM15 | GO:0006915 | apoptotic process | 22505472 |
Hgene | ADAM15 | GO:0045087 | innate immune response | 22505472 |
Hgene | ADAM15 | GO:1904628 | cellular response to phorbol 13-acetate 12-myristate | 22505472 |
Tgene | GALE | GO:0019388 | galactose catabolic process | 16302980 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-BR-8683-01A | ADAM15 | chr1 | 155033308 | + | GALE | chr1 | 24125926 | - |
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Fusion Gene ORF analysis for ADAM15-GALE |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-5UTR | ENST00000472434 | ENST00000374497 | ADAM15 | chr1 | 155033308 | + | GALE | chr1 | 24125926 | - |
3UTR-5UTR | ENST00000472434 | ENST00000470383 | ADAM15 | chr1 | 155033308 | + | GALE | chr1 | 24125926 | - |
5CDS-5UTR | ENST00000271836 | ENST00000374497 | ADAM15 | chr1 | 155033308 | + | GALE | chr1 | 24125926 | - |
5CDS-5UTR | ENST00000271836 | ENST00000470383 | ADAM15 | chr1 | 155033308 | + | GALE | chr1 | 24125926 | - |
5CDS-5UTR | ENST00000355956 | ENST00000374497 | ADAM15 | chr1 | 155033308 | + | GALE | chr1 | 24125926 | - |
5CDS-5UTR | ENST00000355956 | ENST00000470383 | ADAM15 | chr1 | 155033308 | + | GALE | chr1 | 24125926 | - |
5CDS-5UTR | ENST00000356955 | ENST00000374497 | ADAM15 | chr1 | 155033308 | + | GALE | chr1 | 24125926 | - |
5CDS-5UTR | ENST00000356955 | ENST00000470383 | ADAM15 | chr1 | 155033308 | + | GALE | chr1 | 24125926 | - |
5CDS-5UTR | ENST00000359280 | ENST00000374497 | ADAM15 | chr1 | 155033308 | + | GALE | chr1 | 24125926 | - |
5CDS-5UTR | ENST00000359280 | ENST00000470383 | ADAM15 | chr1 | 155033308 | + | GALE | chr1 | 24125926 | - |
5CDS-5UTR | ENST00000368410 | ENST00000374497 | ADAM15 | chr1 | 155033308 | + | GALE | chr1 | 24125926 | - |
5CDS-5UTR | ENST00000368410 | ENST00000470383 | ADAM15 | chr1 | 155033308 | + | GALE | chr1 | 24125926 | - |
5CDS-5UTR | ENST00000368413 | ENST00000374497 | ADAM15 | chr1 | 155033308 | + | GALE | chr1 | 24125926 | - |
5CDS-5UTR | ENST00000368413 | ENST00000470383 | ADAM15 | chr1 | 155033308 | + | GALE | chr1 | 24125926 | - |
5CDS-5UTR | ENST00000449910 | ENST00000374497 | ADAM15 | chr1 | 155033308 | + | GALE | chr1 | 24125926 | - |
5CDS-5UTR | ENST00000449910 | ENST00000470383 | ADAM15 | chr1 | 155033308 | + | GALE | chr1 | 24125926 | - |
5CDS-5UTR | ENST00000531455 | ENST00000374497 | ADAM15 | chr1 | 155033308 | + | GALE | chr1 | 24125926 | - |
5CDS-5UTR | ENST00000531455 | ENST00000470383 | ADAM15 | chr1 | 155033308 | + | GALE | chr1 | 24125926 | - |
intron-5UTR | ENST00000360674 | ENST00000374497 | ADAM15 | chr1 | 155033308 | + | GALE | chr1 | 24125926 | - |
intron-5UTR | ENST00000360674 | ENST00000470383 | ADAM15 | chr1 | 155033308 | + | GALE | chr1 | 24125926 | - |
intron-5UTR | ENST00000368412 | ENST00000374497 | ADAM15 | chr1 | 155033308 | + | GALE | chr1 | 24125926 | - |
intron-5UTR | ENST00000368412 | ENST00000470383 | ADAM15 | chr1 | 155033308 | + | GALE | chr1 | 24125926 | - |
intron-5UTR | ENST00000447332 | ENST00000374497 | ADAM15 | chr1 | 155033308 | + | GALE | chr1 | 24125926 | - |
intron-5UTR | ENST00000447332 | ENST00000470383 | ADAM15 | chr1 | 155033308 | + | GALE | chr1 | 24125926 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for ADAM15-GALE |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for ADAM15-GALE |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:155033308/:24125926) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | GALE |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids. {ECO:0000269|PubMed:22654673, ECO:0000303|PubMed:23732289}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for ADAM15-GALE |
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Fusion Gene PPI Analysis for ADAM15-GALE |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ADAM15-GALE |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ADAM15-GALE |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C0751161 | UDPglucose 4-epimerase deficiency disease | 9 | CTD_human;GENOMICS_ENGLAND;UNIPROT | |
Tgene | C0016952 | Galactosemias | 1 | CTD_human | |
Tgene | C0268151 | Classical galactosemia | 1 | CTD_human | |
Tgene | C0268155 | Deficiency of galactokinase | 1 | CTD_human | |
Tgene | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND |