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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ADAM15-IRF3 (FusionGDB2 ID:HG8751TG3661) |
Fusion Gene Summary for ADAM15-IRF3 |
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Fusion gene information | Fusion gene name: ADAM15-IRF3 | Fusion gene ID: hg8751tg3661 | Hgene | Tgene | Gene symbol | ADAM15 | IRF3 | Gene ID | 8751 | 3661 |
Gene name | ADAM metallopeptidase domain 15 | interferon regulatory factor 3 | |
Synonyms | MDC15 | IIAE7 | |
Cytomap | ('ADAM15')('IRF3') 1q21.3 | 19q13.33 | |
Type of gene | protein-coding | protein-coding | |
Description | disintegrin and metalloproteinase domain-containing protein 15MDC-15a disintegrin and metalloproteinase domain 15 (metargidin)metalloprotease RGD disintegrin proteinmetalloproteinase-like, disintegrin-like, and cysteine-rich protein 15 | interferon regulatory factor 3 | |
Modification date | 20200320 | 20200315 | |
UniProtAcc | . | Q14653 | |
Ensembl transtripts involved in fusion gene | ENST00000472434, ENST00000271836, ENST00000355956, ENST00000356955, ENST00000359280, ENST00000360674, ENST00000368410, ENST00000368412, ENST00000368413, ENST00000447332, ENST00000449910, ENST00000531455, | ||
Fusion gene scores | * DoF score | 6 X 6 X 5=180 | 8 X 5 X 7=280 |
# samples | 7 | 9 | |
** MAII score | log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/280*10)=-1.63742992061529 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ADAM15 [Title/Abstract] AND IRF3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ADAM15(155030917)-IRF3(50163090), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ADAM15 | GO:0002418 | immune response to tumor cell | 22505472 |
Hgene | ADAM15 | GO:0006915 | apoptotic process | 22505472 |
Hgene | ADAM15 | GO:0045087 | innate immune response | 22505472 |
Hgene | ADAM15 | GO:1904628 | cellular response to phorbol 13-acetate 12-myristate | 22505472 |
Tgene | IRF3 | GO:0032481 | positive regulation of type I interferon production | 25636800 |
Tgene | IRF3 | GO:0035666 | TRIF-dependent toll-like receptor signaling pathway | 25636800 |
Tgene | IRF3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9660935 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-BR-A4J9-01A | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
Top |
Fusion Gene ORF analysis for ADAM15-IRF3 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-5UTR | ENST00000472434 | ENST00000309877 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
3UTR-5UTR | ENST00000472434 | ENST00000377135 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
3UTR-5UTR | ENST00000472434 | ENST00000377139 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
3UTR-5UTR | ENST00000472434 | ENST00000593922 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
3UTR-5UTR | ENST00000472434 | ENST00000596765 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
3UTR-5UTR | ENST00000472434 | ENST00000596822 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
3UTR-5UTR | ENST00000472434 | ENST00000597198 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
3UTR-5UTR | ENST00000472434 | ENST00000598808 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
3UTR-5UTR | ENST00000472434 | ENST00000599144 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
3UTR-5UTR | ENST00000472434 | ENST00000599223 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
3UTR-5UTR | ENST00000472434 | ENST00000599680 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
3UTR-5UTR | ENST00000472434 | ENST00000600022 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
3UTR-5UTR | ENST00000472434 | ENST00000600911 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
3UTR-5UTR | ENST00000472434 | ENST00000601291 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
3UTR-intron | ENST00000472434 | ENST00000442265 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000271836 | ENST00000309877 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000271836 | ENST00000377135 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000271836 | ENST00000377139 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000271836 | ENST00000593922 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000271836 | ENST00000596765 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000271836 | ENST00000596822 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000271836 | ENST00000597198 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000271836 | ENST00000598808 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000271836 | ENST00000599144 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000271836 | ENST00000599223 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000271836 | ENST00000599680 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000271836 | ENST00000600022 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000271836 | ENST00000600911 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000271836 | ENST00000601291 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000355956 | ENST00000309877 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000355956 | ENST00000377135 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000355956 | ENST00000377139 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000355956 | ENST00000593922 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000355956 | ENST00000596765 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000355956 | ENST00000596822 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000355956 | ENST00000597198 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000355956 | ENST00000598808 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000355956 | ENST00000599144 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000355956 | ENST00000599223 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000355956 | ENST00000599680 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000355956 | ENST00000600022 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000355956 | ENST00000600911 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000355956 | ENST00000601291 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000356955 | ENST00000309877 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000356955 | ENST00000377135 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000356955 | ENST00000377139 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000356955 | ENST00000593922 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000356955 | ENST00000596765 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000356955 | ENST00000596822 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000356955 | ENST00000597198 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000356955 | ENST00000598808 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000356955 | ENST00000599144 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000356955 | ENST00000599223 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000356955 | ENST00000599680 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000356955 | ENST00000600022 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000356955 | ENST00000600911 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000356955 | ENST00000601291 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000359280 | ENST00000309877 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000359280 | ENST00000377135 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000359280 | ENST00000377139 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000359280 | ENST00000593922 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000359280 | ENST00000596765 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000359280 | ENST00000596822 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000359280 | ENST00000597198 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000359280 | ENST00000598808 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000359280 | ENST00000599144 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000359280 | ENST00000599223 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000359280 | ENST00000599680 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000359280 | ENST00000600022 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000359280 | ENST00000600911 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000359280 | ENST00000601291 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000360674 | ENST00000309877 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000360674 | ENST00000377135 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000360674 | ENST00000377139 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000360674 | ENST00000593922 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000360674 | ENST00000596765 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000360674 | ENST00000596822 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000360674 | ENST00000597198 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000360674 | ENST00000598808 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000360674 | ENST00000599144 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000360674 | ENST00000599223 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000360674 | ENST00000599680 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000360674 | ENST00000600022 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000360674 | ENST00000600911 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000360674 | ENST00000601291 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368410 | ENST00000309877 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368410 | ENST00000377135 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368410 | ENST00000377139 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368410 | ENST00000593922 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368410 | ENST00000596765 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368410 | ENST00000596822 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368410 | ENST00000597198 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368410 | ENST00000598808 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368410 | ENST00000599144 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368410 | ENST00000599223 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368410 | ENST00000599680 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368410 | ENST00000600022 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368410 | ENST00000600911 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368410 | ENST00000601291 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368412 | ENST00000309877 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368412 | ENST00000377135 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368412 | ENST00000377139 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368412 | ENST00000593922 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368412 | ENST00000596765 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368412 | ENST00000596822 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368412 | ENST00000597198 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368412 | ENST00000598808 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368412 | ENST00000599144 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368412 | ENST00000599223 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368412 | ENST00000599680 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368412 | ENST00000600022 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368412 | ENST00000600911 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368412 | ENST00000601291 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368413 | ENST00000309877 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368413 | ENST00000377135 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368413 | ENST00000377139 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368413 | ENST00000593922 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368413 | ENST00000596765 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368413 | ENST00000596822 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368413 | ENST00000597198 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368413 | ENST00000598808 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368413 | ENST00000599144 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368413 | ENST00000599223 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368413 | ENST00000599680 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368413 | ENST00000600022 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368413 | ENST00000600911 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000368413 | ENST00000601291 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000447332 | ENST00000309877 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000447332 | ENST00000377135 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000447332 | ENST00000377139 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000447332 | ENST00000593922 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000447332 | ENST00000596765 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000447332 | ENST00000596822 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000447332 | ENST00000597198 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000447332 | ENST00000598808 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000447332 | ENST00000599144 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000447332 | ENST00000599223 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000447332 | ENST00000599680 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000447332 | ENST00000600022 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000447332 | ENST00000600911 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000447332 | ENST00000601291 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000449910 | ENST00000309877 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000449910 | ENST00000377135 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000449910 | ENST00000377139 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000449910 | ENST00000593922 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000449910 | ENST00000596765 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000449910 | ENST00000596822 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000449910 | ENST00000597198 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000449910 | ENST00000598808 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000449910 | ENST00000599144 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000449910 | ENST00000599223 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000449910 | ENST00000599680 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000449910 | ENST00000600022 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000449910 | ENST00000600911 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000449910 | ENST00000601291 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000531455 | ENST00000309877 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000531455 | ENST00000377135 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000531455 | ENST00000377139 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000531455 | ENST00000593922 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000531455 | ENST00000596765 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000531455 | ENST00000596822 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000531455 | ENST00000597198 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000531455 | ENST00000598808 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000531455 | ENST00000599144 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000531455 | ENST00000599223 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000531455 | ENST00000599680 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000531455 | ENST00000600022 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000531455 | ENST00000600911 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-5UTR | ENST00000531455 | ENST00000601291 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-intron | ENST00000271836 | ENST00000442265 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-intron | ENST00000355956 | ENST00000442265 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-intron | ENST00000356955 | ENST00000442265 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-intron | ENST00000359280 | ENST00000442265 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-intron | ENST00000360674 | ENST00000442265 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-intron | ENST00000368410 | ENST00000442265 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-intron | ENST00000368412 | ENST00000442265 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-intron | ENST00000368413 | ENST00000442265 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-intron | ENST00000447332 | ENST00000442265 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-intron | ENST00000449910 | ENST00000442265 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
5CDS-intron | ENST00000531455 | ENST00000442265 | ADAM15 | chr1 | 155030917 | + | IRF3 | chr19 | 50163090 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for ADAM15-IRF3 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for ADAM15-IRF3 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:155030917/:50163090) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | IRF3 |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:25636800, PubMed:27302953). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953, PubMed:33440148). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591). In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148). {ECO:0000269|PubMed:16154084, ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:31413131, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33440148, ECO:0000303|PubMed:11846977, ECO:0000303|PubMed:16846591, ECO:0000303|PubMed:16979567, ECO:0000303|PubMed:20049431}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for ADAM15-IRF3 |
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Fusion Gene PPI Analysis for ADAM15-IRF3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ADAM15-IRF3 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ADAM15-IRF3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C4225294 | ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 7 | 2 | GENOMICS_ENGLAND;UNIPROT |