Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ADAM9-ADAM28 (FusionGDB2 ID:HG8754TG10863)

Fusion Gene Summary for ADAM9-ADAM28

check button Fusion gene summary
Fusion gene informationFusion gene name: ADAM9-ADAM28
Fusion gene ID: hg8754tg10863
HgeneTgene
Gene symbol

ADAM9

ADAM28

Gene ID

8754

10863

Gene nameADAM metallopeptidase domain 9ADAM metallopeptidase domain 28
SynonymsCORD9|MCMP|MDC9|MltngADAM 28|MDC-L|MDCL|eMDC II|eMDCII
Cytomap('ADAM9')('ADAM28')

8p11.22

8p21.2

Type of geneprotein-codingprotein-coding
Descriptiondisintegrin and metalloproteinase domain-containing protein 9ADAM metallopeptidase domain 9 (meltrin gamma)cellular disintegrin-related proteincone rod dystrophy 9metalloprotease/disintegrin/cysteine-rich protein 9myeloma cell metalloproteinasedisintegrin and metalloproteinase domain-containing protein 28epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein IIepididymial metalloproteinase-like, disintegrin-like, and cysteine-rich protein IIepididymis secretory sperm
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000466936, ENST00000481513, 
ENST00000487273, ENST00000484143, 
Fusion gene scores* DoF score27 X 19 X 12=61565 X 6 X 4=120
# samples 315
** MAII scorelog2(31/6156*10)=-4.31165311105397
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/120*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADAM9 [Title/Abstract] AND ADAM28 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADAM9(38871562)-ADAM28(24168873), # samples:1
Anticipated loss of major functional domain due to fusion event.ADAM9-ADAM28 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAM9-ADAM28 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAM9-ADAM28 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAM9-ADAM28 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAM9-ADAM28 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ADAM9-ADAM28 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADAM9

GO:0000186

activation of MAPKK activity

17704059

HgeneADAM9

GO:0006509

membrane protein ectodomain proteolysis

9920899

HgeneADAM9

GO:0034612

response to tumor necrosis factor

11831872

HgeneADAM9

GO:0050714

positive regulation of protein secretion

17704059


check buttonFusion gene breakpoints across ADAM9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ADAM28 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer2397NADAM9chr8

38871562

+ADAM28chr8

24168873

+


Top

Fusion Gene ORF analysis for ADAM9-ADAM28

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000466936ENST00000397649ADAM9chr8

38871562

+ADAM28chr8

24168873

+
5CDS-5UTRENST00000466936ENST00000437154ADAM9chr8

38871562

+ADAM28chr8

24168873

+
5CDS-5UTRENST00000466936ENST00000540823ADAM9chr8

38871562

+ADAM28chr8

24168873

+
5CDS-5UTRENST00000481513ENST00000397649ADAM9chr8

38871562

+ADAM28chr8

24168873

+
5CDS-5UTRENST00000481513ENST00000437154ADAM9chr8

38871562

+ADAM28chr8

24168873

+
5CDS-5UTRENST00000481513ENST00000540823ADAM9chr8

38871562

+ADAM28chr8

24168873

+
5CDS-5UTRENST00000487273ENST00000397649ADAM9chr8

38871562

+ADAM28chr8

24168873

+
5CDS-5UTRENST00000487273ENST00000437154ADAM9chr8

38871562

+ADAM28chr8

24168873

+
5CDS-5UTRENST00000487273ENST00000540823ADAM9chr8

38871562

+ADAM28chr8

24168873

+
5CDS-intronENST00000466936ENST00000518516ADAM9chr8

38871562

+ADAM28chr8

24168873

+
5CDS-intronENST00000481513ENST00000518516ADAM9chr8

38871562

+ADAM28chr8

24168873

+
5CDS-intronENST00000487273ENST00000518516ADAM9chr8

38871562

+ADAM28chr8

24168873

+
Frame-shiftENST00000481513ENST00000265769ADAM9chr8

38871562

+ADAM28chr8

24168873

+
In-frameENST00000466936ENST00000265769ADAM9chr8

38871562

+ADAM28chr8

24168873

+
In-frameENST00000487273ENST00000265769ADAM9chr8

38871562

+ADAM28chr8

24168873

+
intron-3CDSENST00000484143ENST00000265769ADAM9chr8

38871562

+ADAM28chr8

24168873

+
intron-5UTRENST00000484143ENST00000397649ADAM9chr8

38871562

+ADAM28chr8

24168873

+
intron-5UTRENST00000484143ENST00000437154ADAM9chr8

38871562

+ADAM28chr8

24168873

+
intron-5UTRENST00000484143ENST00000540823ADAM9chr8

38871562

+ADAM28chr8

24168873

+
intron-intronENST00000484143ENST00000518516ADAM9chr8

38871562

+ADAM28chr8

24168873

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000487273ADAM9chr838871562+ENST00000265769ADAM28chr824168873+7047411782432784
ENST00000466936ADAM9chr838871562+ENST00000265769ADAM28chr824168873+71645281952549784

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000487273ENST00000265769ADAM9chr838871562+ADAM28chr824168873+3.06E-050.99996936
ENST00000466936ENST00000265769ADAM9chr838871562+ADAM28chr824168873+3.02E-050.9999697

Top

Fusion Genomic Features for ADAM9-ADAM28


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ADAM9chr838871562+ADAM28chr824168873+7.04E-060.99999297
ADAM9chr838871562+ADAM28chr824168873+7.04E-060.99999297

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for ADAM9-ADAM28


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:38871562/chr8:24168873)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneADAM28chr8:38871562chr8:24168873ENST00000265769323494_628102776.0Compositional biasNote=Cys-rich
TgeneADAM28chr8:38871562chr8:24168873ENST00000437154314494_628102541.0Compositional biasNote=Cys-rich
TgeneADAM28chr8:38871562chr8:24168873ENST00000265769323204_399102776.0DomainPeptidase M12B
TgeneADAM28chr8:38871562chr8:24168873ENST00000265769323407_493102776.0DomainDisintegrin
TgeneADAM28chr8:38871562chr8:24168873ENST00000265769323625_657102776.0DomainEGF-like
TgeneADAM28chr8:38871562chr8:24168873ENST00000437154314204_399102541.0DomainPeptidase M12B
TgeneADAM28chr8:38871562chr8:24168873ENST00000437154314407_493102541.0DomainDisintegrin
TgeneADAM28chr8:38871562chr8:24168873ENST00000437154314625_657102541.0DomainEGF-like
TgeneADAM28chr8:38871562chr8:24168873ENST00000265769323167_174102776.0MotifCysteine switch
TgeneADAM28chr8:38871562chr8:24168873ENST00000437154314167_174102541.0MotifCysteine switch
TgeneADAM28chr8:38871562chr8:24168873ENST00000265769323199_665102776.0Topological domainExtracellular
TgeneADAM28chr8:38871562chr8:24168873ENST00000265769323687_775102776.0Topological domainCytoplasmic
TgeneADAM28chr8:38871562chr8:24168873ENST00000437154314199_665102541.0Topological domainExtracellular
TgeneADAM28chr8:38871562chr8:24168873ENST00000437154314687_775102541.0Topological domainCytoplasmic
TgeneADAM28chr8:38871562chr8:24168873ENST00000265769323666_686102776.0TransmembraneHelical
TgeneADAM28chr8:38871562chr8:24168873ENST00000437154314666_686102541.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAM9chr8:38871562chr8:24168873ENST00000487273+422505_634111820.0Compositional biasNote=Cys-rich
HgeneADAM9chr8:38871562chr8:24168873ENST00000487273+422790_795111820.0Compositional biasNote=Poly-Pro
HgeneADAM9chr8:38871562chr8:24168873ENST00000487273+422212_406111820.0DomainPeptidase M12B
HgeneADAM9chr8:38871562chr8:24168873ENST00000487273+422414_501111820.0DomainDisintegrin
HgeneADAM9chr8:38871562chr8:24168873ENST00000487273+422644_698111820.0DomainEGF-like
HgeneADAM9chr8:38871562chr8:24168873ENST00000487273+42229_697111820.0Topological domainExtracellular
HgeneADAM9chr8:38871562chr8:24168873ENST00000487273+422719_819111820.0Topological domainCytoplasmic
HgeneADAM9chr8:38871562chr8:24168873ENST00000487273+422698_718111820.0TransmembraneHelical


Top

Fusion Gene Sequence for ADAM9-ADAM28


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2007_2007_1_ADAM9-ADAM28_ADAM9_chr8_38871562_ENST00000466936_ADAM28_chr8_24168873_ENST00000265769_length(transcript)=7164nt_BP=528nt
TAGGCGATGTCGGGAGCGAGCTCGGACCGAGGGCTCAGTTGCGTCAGTGCCGCGCGCGTGCTCGTCGGGCGCGCGTGCTCGTCGGGCGCG
CGCGCTTCCCGGCCAGACTTGGGGCCCCGGCAGGGTTGGAAAATGATGGAAGAGGCGGAGGTGGAGGCGACCGAGTGCTGAGAGGAACCT
GCGGAATCGGCCGAGATGGGGTCTGGCGCGCGCTTTCCCTCGGGGACCCTTCGTGTCCGGTGGTTGCTGTTGCTTGGCCTGGTGGGCCCA
GTCCTCGGTGCGGCGCGGCCAGGCTTTCAACAGACCTCACATCTTTCTTCTTATGAAATTATAACTCCTTGGAGATTAACTAGAGAAAGA
AGAGAAGCCCCTAGGCCCTATTCAAAACAAGTATCTTATGTTATTCAGGCTGAAGGAAAAGAGCATATTATTCACTTGGAAAGGAACAAA
GACCTTTTGCCTGAAGATTTTGTGGTTTATACTTACAACAAGGAAGGGACTTTAATCACTGACCATCCCAATATACAGGATGATTGTTAT
TATCAAGGACATATTCTTAATGAAAAGGTTTCTGACGCTAGCATCAGCACATGTAGGGGTCTAAGGGGCTACTTCAGTCAGGGGGATCAA
AGATACTTTATTGAACCTTTAAGCCCCATACATCGGGATGGACAGGAGCATGCACTCTTCAAGTATAACCCTGATGAAAAGAATTATGAC
AGCACCTGTGGGATGGATGGTGTGTTGTGGGCCCACGATTTGCAGCAGAACATTGCCCTACCTGCCACCAAACTAGTAAAATTGAAAGAC
AGGAAGGTTCAGGAACATGAGAAATACATAGAATATTATTTGGTCCTGGATAATGGTGAGTTTAAAAGGTACAATGAGAATCAAGATGAG
ATCAGAAAGAGGGTATTTGAGATGGCTAATTATGTCAACATGCTTTATAAAAAGCTCAATACTCATGTGGCCTTAGTTGGTATGGAAATC
TGGACTGACAAGGATAAGATAAAGATAACCCCAAATGCAAGCTTCACCTTGGAGAATTTTTCTAAATGGAGGGGGAGTGTTCTCTCAAGA
AGAAAGCGTCATGATATTGCTCAGTTAATCACAGCAACAGAACTTGCTGGAACGACTGTGGGTCTTGCATTTATGTCTACAATGTGTTCT
CCTTATTCTGTTGGCGTTGTTCAGGACCACAGCGATAATCTTCTTAGAGTTGCAGGGACAATGGCACATGAAATGGGCCACAACTTTGGA
ATGTTTCATGACGACTATTCTTGCAAGTGTCCTTCTACAATATGTGTGATGGACAAAGCACTGAGCTTCTATATACCCACAGACTTCAGT
TCCTGCAGCCGTCTCAGCTATGACAAGTTTTTTGAAGATAAATTATCAAATTGCCTCTTTAATGCTCCATTGCCTACAGATATCATATCC
ACTCCAATTTGTGGGAACCAGTTGGTGGAAATGGGAGAGGACTGTGATTGTGGGACATCTGAGGAATGTACCAATATTTGCTGTGATGCT
AAGACATGTAAAATCAAAGCAACTTTTCAATGTGCATTAGGAGAATGTTGTGAAAAATGCCAATTTAAAAAGGCTGGGATGGTGTGCAGA
CCAGCAAAAGATGAGTGCGACCTGCCTGAAATGTGTAATGGTAAATCTGGTAATTGTCCTGATGATAGATTCCAAGTCAATGGCTTCCCT
TGCCATCACGGGAAGGGCCACTGCTTGATGGGGACATGCCCCACACTGCAGGAGCAGTGCACAGAGCTGTGGGGACCAGGAACTGAGGTT
GCAGATAAGTCATGTTACAACAGGAATGAAGGTGGGTCAAAGTACGGGTACTGTCGCAGAGTGGATGACACACTCATTCCCTGCAAAGCA
AATGATACCATGTGTGGGAAGTTGTTCTGTCAAGGTGGGTCGGATAATTTGCCCTGGAAAGGACGGATAGTGACTTTCCTGACATGTAAA
ACATTTGATCCTGAAGACACAAGTCAAGAAATAGGCATGGTGGCCAATGGAACTAAGTGTGGCGATAACAAGGTTTGCATTAATGCAGAA
TGTGTGGATATTGAGAAAGCCTACAAATCAACCAATTGCTCATCTAAGTGCAAAGGACATGCTGTGTGTGACCATGAGCTCCAGTGTCAA
TGTGAGGAAGGATGGATCCCTCCCGACTGCGATGACTCCTCAGTGGTCTTCCACTTCTCCATTGTGGTTGGGGTGCTGTTCCCAATGGCG
GTCATTTTTGTGGTGGTTGCTATGGTAATCCGGCACCAGAGCTCCAGAGAAAAGCAGAAGAAAGATCAGAGGCCACTATCTACCACTGGC
ACCAGGCCACACAAACAGAAGAGGAAACCCCAGATGGTAAAGGCTGTTCAACCCCAAGAGATGAGTCAGATGAAGCCCCATGTGTATGAT
CTGCCAGTAGAAGGCAATGAGCCCCCAGCCTCTTTTCATAAAGACACAAACGCACTTCCCCCTACTGTTTTCAAGGATAATCCAGTGTCT
ACACCTAAGGACTCAAATCCAAAAGCATGAAGCAACAGCTAAGCAAGAACTAATGGCTAAATTATCAACTTGGAAAACTGGAAAATCTGG
ATGGCAGAGAAATATACTATCTATCTCACCAGTATTTGCTCTCGACTCAAGAAGGTTAACATTTTCTGATTCATGTTAGACTTTGAAGAG
ACTAAAGAAAATTTTCAAGAGGAACATATGCCTGAGAACCTTTGCATGAATTTAAAATTTCAATTATCCATTCTTATAAGAAGGAAGATG
ATTGTAAAGAAATATCTCCGAAGTTAAAATCTGTAATAGGAATTGATTCATTCTCTAATGAAAACAAAACATAAAAACATCACACTAATC
TTGGAGGAATAAGAAAAATTGTACATCCATTAAATGTACAATTGATTGCAACATCTTGATTGTTTTAACCATTAACTTGTCAAATTACAA
TCACAGTTAAGAAAATGATGTAAAATTCTGTTTTGTGGATCTCTTTCCTAGATTAGCTTCTGAAATCATTATTAGCTATATCATTTGAGG
TTTTCTACAATTTGGTATAACTAAGAATTTAAAAATGTTTTATCATATATATTTGTATAATTAATTACTGGCATGGTTAAAGTGGTTTTC
ACTTTTTAAATGGAGAAAATTTCAGTTAAATTAATAGGATAAACCAGGTTGCGAACTGGTGACCTGTAGGCCATGTTTGCACTGCAAATA
TATTTGGTCTGAATGATATTGATATTGGACACATAGTACTTTTACATGTTTTGAATGTATTGCTAATATTTAAAAATTGAGAGATCTTGC
ATAAACAATAGATTCCCAGCTTTGTCAGATGTAATCTAAAAGTAATCCGATGCTTTGTCAACAACAGACTTACATTGCCCATAGCAACCG
TCAGCTTAGTTGATGGGTAATGTAGCAAACACTATTGGTTTCCTACCAAATAATCCCCTTTTTCCTGGCTTTTAGAACAATAATTTTGTT
CACCTGCCCACTTCTAGGAAAGAATATCCTATCTAATCTATCTATCTCAGGGATAAATCCCTATCCTTTTAAGTAAGTCAAGTCAATTAA
AATAACCTCATTTTTCCTTGCTAGTGGTCGACTTGGAGATGATTTTATAATCCTCCCCCTCCCTTTTTTTTTTTGCTAGTAAGACGACAG
AGGAATTATGTTACAACACTTCTGGAAAATTTTTCCTCGTCTCTTTTTCTGGATATGGGCATCTGAATACTCTAGCTGGTACTGCTGCGC
TCCACACGGTGATTATGAAGGCTGAAAAAGATAGATAGAGCAGAAAGATGAAAAGAATAAAACCTGGCCTTTCAATGATGTCATGGAATT
GGTAGATCAGTGACTGCTGGAGTTACCTCACACTTTCTTGGTACTCCTTATTATATGAGCCATACATTTTCCTTGTTGTTTAAGCCATTT
TGAATTGGATTTTCTCTCACTTTCAACAGAGATCATCCTAACTAGTAAAGTAGCTGTTTCCATAATCAGGGAACATGCTTTAGTTCATCA
TCACAGCTACAGTTTTTCTTGTATTTGTCTGCTTCACCCATTTCTATCAATCACTTACCTGGTCCCCACAGGCCTGTCGCTTCATGAGGA
ACTTTATGGTTCATTTACCCTTGCAGTATGAGGTTCTAGATAAGCCCACTCTGGCCTCAAAAGTGAAGCTCAGTCCTCAGGAAATCCAGA
GTCCACTGATCAAATCACTGTCAAGGATACAGGCTTTTTCTCCATGTGGCATTTGCAGAAGAACAACTTTAAAAGTAGAGCTTTATCTGC
CCTGTGAGGTTTCAGAAGACCCTCCCCTGACCCAGAAATAAATCCCTATTTCCTGGAAAGCCATTATGTACTCGTGACCAACTTGTGAAC
TTTTCTGTGTTGTTGTTGTTGTTTTTTAAATATCTGTCCCCAGTAATAGATTCACCTAATCCTTTTTTATACTGATGGAATGGAAATCTT
AAATCTATGAATCCTCAACTAGCCATGTACCATAACCCAAGCAAAAACTAAACCATACACTCTCAAAAGCAGTGGCATGTGAACATGCCT
GCAAGTTCCTAAATGATGTCACTAGGTCCCTGATGCAGATGCATCATACGTCCTATTTGAAGAGAAGAAATGCAGTACAATGACAGGAAA
ACCATTATTTTATCATAGAACTGCGAACCCAAGTCCTACAATGTTTCCCTTTCAGCTCAACTGCAGAATAGTTTAGAACAGACTTTTTGA
TTTCACAATACTGTTTCCACACTTACTTATATCCGTAACTTTCTAACTTTAAGGGAATTCCGCTTATTTGACATTTAACTACCTCAGATA
TGCCACCAAACCTGTTTTCATCATTAGTTATTTTTACCTTGTCTACTTTAAAACAGTGAAATTATTAGGTTAAATTATGTTTTTATCCAG
TTACTCTAAGATACCTTAGTGTTTGTCTACTTATTACAACTCACCAAATTACTGGTTTTATATGGCCTTTGGGAAGGCTTTTAGCTTTTT
ATAAAATAATGAAGTATGCATGAAAAGAAAGCAAATTTTAGTTGGTTGCAGTCAGAGAATATGGAAAGGGTTATTATTATAATTAGGATT
TTATTATTCACATTGGAAATCACTGCTATGTGTTAAGGAATTGAAGGTGGCCTCTGGCTAGCAGCCATTAAGAAAATGAGCCCCTGAGTT
CAACGACCCTCAAATGAAGTGAAGTCTACCAATAACCACTGAATAAGCTTGGAATTTTAGATTCCTTCCCAGCTGAATCTTGACTTCAGC
CTTGTGAGACACCCTGAAGTAGAGGATGCAGCTAAATTTTGTCCAGATTACACACCCACAGAAACTGTATGATAATTAATATGTGTTGTT
TAAAGTTGTTATGGTTTGGAGATATTTGTTATGCAGCAATAGATAGCTGATACAAGGAAGTAGAGAACAAACATTTTCTATTAGTCTGTT
TTCACATGGCTATAAAGAATACCACCTGAGACTGGGTAATTTATAAAGAAAGGAGGATTAATTGACTCAGATTTCCACATGGCCTAGGAG
GCCTCAGGAAACTTACAATCATGATGAAAGAGGAAGCAGAAACATCTCATATGATGGAAGATGTGTATGAAGGAGGAACTGTCAAACACT
TATAAAACCATCAGATCTCTTGAGAGCTTACTATCTCGACAAAAGCATGGGGGAAACCACCCCCATGATCCAATCACCTCCCACCTGGTC
CCTCCCTCAACATGTGGAGATTATAGCAATTAAAAAAATGAGATTTGGGGGGATGGACACAGAGCCAAACCATATAATGTTTTAAATGCT
CCAGATAGGTTTAGGTAAAATTAACTATATTTAATAGGCTTTCATCACTGCAAAACTTTTTTTCCTTTCTTTGTGTCTCTAGTCTCTTCC
ATTTGTTCTCCCTTCTTTACTAGCACCGAGGATTTGCTTGAAATCTCTGATAGCCAGTATTCTCATTTATCATATTCTTTCTCACTTTGT
GTTTCCTTGGTAATTTTGGATAACTCCTTAAATTTATCTTCCAAATTACTGGTTTTTATATTCTGTACTGTCAGTCCTCCTGTTCACTAA
TTTCAAAATTTATAGTTGTTTCTCTTGTTTACTTATATAGTTGTTTCTCTTGTTTACTTAATAACATTCTCTTCTTTCCTATCAGTTTAA
TTTTATAAAGGCTAACCAATTAACTGTTTTTAACTTATATTTCCAGATATTTTAAAAATTAAAGCAAAATGTGTATAAACTTTATTACTG
CTTCCCACAGTAAATATTTTTCAGAAGTACATGCTTTCTCAGCCACTTGACTAGTATGTTCCCCATCATTCAAAGACACCATTATTTCCT
AAGTGTTATATTGCTATTTTTCAGTTGGTGCATCCAATATTATTATCAGCTTTAATATTGTTTCATCATATGTCATTGTTCAAAGAATCC
ATCTCTTGAGCGTAAGCTAAATAATTTGCATACACTAGCATCTGGATGTAATATGGAAAAATATGGAAATGGTTGGGGTGATAAGCAAGT
CTTGCATATTCTTTTCTCCTCAATTTTTTTTCTCCAAAGTGGGCCAAGCCAAGAGTGGCACAGCTGTGTGGAGATACTGAGCTCCACCTT
GTCAGGGAAGATCCCAACTCAGGAGAAAACACCTCTAACAAAATCTGTAGCCACGTTGGCACATCTGCCCTTGAATTCACTTTGTCTCTT
TTGCTGCTTCCATAAAAAGGCTTTCCCTTGACAATGTTAGGCACTTTTTAGCAACTAGGCCTGGGTGGTCTGCTACAATGCCCAACACTT
AATACAGTATCACTATTACTGTTAGTAGTATGCTAAGCGAATACTATTGTTATAAAAAAAATCCTAAGCATGAAAATTACGGTATACAAT
TTATTGTGAAGGCAACTTCTTGTGAACATTAAACGGTTTATCTCCTTCACCTCATATTAAAGTCCATACTCTTGGGATATATCTGACATC
TCAATATTAAATGACTAAGATGACTAAGTCGTTTATGTTGCTCCCACCTCACACAAAGTTAAAACTATTTGTTACTTTAAATAGTTTGAC

>2007_2007_1_ADAM9-ADAM28_ADAM9_chr8_38871562_ENST00000466936_ADAM28_chr8_24168873_ENST00000265769_length(amino acids)=784AA_BP=111
MGSGARFPSGTLRVRWLLLLGLVGPVLGAARPGFQQTSHLSSYEIITPWRLTRERREAPRPYSKQVSYVIQAEGKEHIIHLERNKDLLPE
DFVVYTYNKEGTLITDHPNIQDDCYYQGHILNEKVSDASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGM
DGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKD
KIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDD
YSCKCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKI
KATFQCALGECCEKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGTEVADKSC
YNRNEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQGGSDNLPWKGRIVTFLTCKTFDPEDTSQEIGMVANGTKCGDNKVCINAECVDIE
KAYKSTNCSSKCKGHAVCDHELQCQCEEGWIPPDCDDSSVVFHFSIVVGVLFPMAVIFVVVAMVIRHQSSREKQKKDQRPLSTTGTRPHK

--------------------------------------------------------------
>2007_2007_2_ADAM9-ADAM28_ADAM9_chr8_38871562_ENST00000487273_ADAM28_chr8_24168873_ENST00000265769_length(transcript)=7047nt_BP=411nt
CGGCAGGGTTGGAAAATGATGGAAGAGGCGGAGGTGGAGGCGACCGAGTGCTGAGAGGAACCTGCGGAATCGGCCGAGATGGGGTCTGGC
GCGCGCTTTCCCTCGGGGACCCTTCGTGTCCGGTGGTTGCTGTTGCTTGGCCTGGTGGGCCCAGTCCTCGGTGCGGCGCGGCCAGGCTTT
CAACAGACCTCACATCTTTCTTCTTATGAAATTATAACTCCTTGGAGATTAACTAGAGAAAGAAGAGAAGCCCCTAGGCCCTATTCAAAA
CAAGTATCTTATGTTATTCAGGCTGAAGGAAAAGAGCATATTATTCACTTGGAAAGGAACAAAGACCTTTTGCCTGAAGATTTTGTGGTT
TATACTTACAACAAGGAAGGGACTTTAATCACTGACCATCCCAATATACAGGATGATTGTTATTATCAAGGACATATTCTTAATGAAAAG
GTTTCTGACGCTAGCATCAGCACATGTAGGGGTCTAAGGGGCTACTTCAGTCAGGGGGATCAAAGATACTTTATTGAACCTTTAAGCCCC
ATACATCGGGATGGACAGGAGCATGCACTCTTCAAGTATAACCCTGATGAAAAGAATTATGACAGCACCTGTGGGATGGATGGTGTGTTG
TGGGCCCACGATTTGCAGCAGAACATTGCCCTACCTGCCACCAAACTAGTAAAATTGAAAGACAGGAAGGTTCAGGAACATGAGAAATAC
ATAGAATATTATTTGGTCCTGGATAATGGTGAGTTTAAAAGGTACAATGAGAATCAAGATGAGATCAGAAAGAGGGTATTTGAGATGGCT
AATTATGTCAACATGCTTTATAAAAAGCTCAATACTCATGTGGCCTTAGTTGGTATGGAAATCTGGACTGACAAGGATAAGATAAAGATA
ACCCCAAATGCAAGCTTCACCTTGGAGAATTTTTCTAAATGGAGGGGGAGTGTTCTCTCAAGAAGAAAGCGTCATGATATTGCTCAGTTA
ATCACAGCAACAGAACTTGCTGGAACGACTGTGGGTCTTGCATTTATGTCTACAATGTGTTCTCCTTATTCTGTTGGCGTTGTTCAGGAC
CACAGCGATAATCTTCTTAGAGTTGCAGGGACAATGGCACATGAAATGGGCCACAACTTTGGAATGTTTCATGACGACTATTCTTGCAAG
TGTCCTTCTACAATATGTGTGATGGACAAAGCACTGAGCTTCTATATACCCACAGACTTCAGTTCCTGCAGCCGTCTCAGCTATGACAAG
TTTTTTGAAGATAAATTATCAAATTGCCTCTTTAATGCTCCATTGCCTACAGATATCATATCCACTCCAATTTGTGGGAACCAGTTGGTG
GAAATGGGAGAGGACTGTGATTGTGGGACATCTGAGGAATGTACCAATATTTGCTGTGATGCTAAGACATGTAAAATCAAAGCAACTTTT
CAATGTGCATTAGGAGAATGTTGTGAAAAATGCCAATTTAAAAAGGCTGGGATGGTGTGCAGACCAGCAAAAGATGAGTGCGACCTGCCT
GAAATGTGTAATGGTAAATCTGGTAATTGTCCTGATGATAGATTCCAAGTCAATGGCTTCCCTTGCCATCACGGGAAGGGCCACTGCTTG
ATGGGGACATGCCCCACACTGCAGGAGCAGTGCACAGAGCTGTGGGGACCAGGAACTGAGGTTGCAGATAAGTCATGTTACAACAGGAAT
GAAGGTGGGTCAAAGTACGGGTACTGTCGCAGAGTGGATGACACACTCATTCCCTGCAAAGCAAATGATACCATGTGTGGGAAGTTGTTC
TGTCAAGGTGGGTCGGATAATTTGCCCTGGAAAGGACGGATAGTGACTTTCCTGACATGTAAAACATTTGATCCTGAAGACACAAGTCAA
GAAATAGGCATGGTGGCCAATGGAACTAAGTGTGGCGATAACAAGGTTTGCATTAATGCAGAATGTGTGGATATTGAGAAAGCCTACAAA
TCAACCAATTGCTCATCTAAGTGCAAAGGACATGCTGTGTGTGACCATGAGCTCCAGTGTCAATGTGAGGAAGGATGGATCCCTCCCGAC
TGCGATGACTCCTCAGTGGTCTTCCACTTCTCCATTGTGGTTGGGGTGCTGTTCCCAATGGCGGTCATTTTTGTGGTGGTTGCTATGGTA
ATCCGGCACCAGAGCTCCAGAGAAAAGCAGAAGAAAGATCAGAGGCCACTATCTACCACTGGCACCAGGCCACACAAACAGAAGAGGAAA
CCCCAGATGGTAAAGGCTGTTCAACCCCAAGAGATGAGTCAGATGAAGCCCCATGTGTATGATCTGCCAGTAGAAGGCAATGAGCCCCCA
GCCTCTTTTCATAAAGACACAAACGCACTTCCCCCTACTGTTTTCAAGGATAATCCAGTGTCTACACCTAAGGACTCAAATCCAAAAGCA
TGAAGCAACAGCTAAGCAAGAACTAATGGCTAAATTATCAACTTGGAAAACTGGAAAATCTGGATGGCAGAGAAATATACTATCTATCTC
ACCAGTATTTGCTCTCGACTCAAGAAGGTTAACATTTTCTGATTCATGTTAGACTTTGAAGAGACTAAAGAAAATTTTCAAGAGGAACAT
ATGCCTGAGAACCTTTGCATGAATTTAAAATTTCAATTATCCATTCTTATAAGAAGGAAGATGATTGTAAAGAAATATCTCCGAAGTTAA
AATCTGTAATAGGAATTGATTCATTCTCTAATGAAAACAAAACATAAAAACATCACACTAATCTTGGAGGAATAAGAAAAATTGTACATC
CATTAAATGTACAATTGATTGCAACATCTTGATTGTTTTAACCATTAACTTGTCAAATTACAATCACAGTTAAGAAAATGATGTAAAATT
CTGTTTTGTGGATCTCTTTCCTAGATTAGCTTCTGAAATCATTATTAGCTATATCATTTGAGGTTTTCTACAATTTGGTATAACTAAGAA
TTTAAAAATGTTTTATCATATATATTTGTATAATTAATTACTGGCATGGTTAAAGTGGTTTTCACTTTTTAAATGGAGAAAATTTCAGTT
AAATTAATAGGATAAACCAGGTTGCGAACTGGTGACCTGTAGGCCATGTTTGCACTGCAAATATATTTGGTCTGAATGATATTGATATTG
GACACATAGTACTTTTACATGTTTTGAATGTATTGCTAATATTTAAAAATTGAGAGATCTTGCATAAACAATAGATTCCCAGCTTTGTCA
GATGTAATCTAAAAGTAATCCGATGCTTTGTCAACAACAGACTTACATTGCCCATAGCAACCGTCAGCTTAGTTGATGGGTAATGTAGCA
AACACTATTGGTTTCCTACCAAATAATCCCCTTTTTCCTGGCTTTTAGAACAATAATTTTGTTCACCTGCCCACTTCTAGGAAAGAATAT
CCTATCTAATCTATCTATCTCAGGGATAAATCCCTATCCTTTTAAGTAAGTCAAGTCAATTAAAATAACCTCATTTTTCCTTGCTAGTGG
TCGACTTGGAGATGATTTTATAATCCTCCCCCTCCCTTTTTTTTTTTGCTAGTAAGACGACAGAGGAATTATGTTACAACACTTCTGGAA
AATTTTTCCTCGTCTCTTTTTCTGGATATGGGCATCTGAATACTCTAGCTGGTACTGCTGCGCTCCACACGGTGATTATGAAGGCTGAAA
AAGATAGATAGAGCAGAAAGATGAAAAGAATAAAACCTGGCCTTTCAATGATGTCATGGAATTGGTAGATCAGTGACTGCTGGAGTTACC
TCACACTTTCTTGGTACTCCTTATTATATGAGCCATACATTTTCCTTGTTGTTTAAGCCATTTTGAATTGGATTTTCTCTCACTTTCAAC
AGAGATCATCCTAACTAGTAAAGTAGCTGTTTCCATAATCAGGGAACATGCTTTAGTTCATCATCACAGCTACAGTTTTTCTTGTATTTG
TCTGCTTCACCCATTTCTATCAATCACTTACCTGGTCCCCACAGGCCTGTCGCTTCATGAGGAACTTTATGGTTCATTTACCCTTGCAGT
ATGAGGTTCTAGATAAGCCCACTCTGGCCTCAAAAGTGAAGCTCAGTCCTCAGGAAATCCAGAGTCCACTGATCAAATCACTGTCAAGGA
TACAGGCTTTTTCTCCATGTGGCATTTGCAGAAGAACAACTTTAAAAGTAGAGCTTTATCTGCCCTGTGAGGTTTCAGAAGACCCTCCCC
TGACCCAGAAATAAATCCCTATTTCCTGGAAAGCCATTATGTACTCGTGACCAACTTGTGAACTTTTCTGTGTTGTTGTTGTTGTTTTTT
AAATATCTGTCCCCAGTAATAGATTCACCTAATCCTTTTTTATACTGATGGAATGGAAATCTTAAATCTATGAATCCTCAACTAGCCATG
TACCATAACCCAAGCAAAAACTAAACCATACACTCTCAAAAGCAGTGGCATGTGAACATGCCTGCAAGTTCCTAAATGATGTCACTAGGT
CCCTGATGCAGATGCATCATACGTCCTATTTGAAGAGAAGAAATGCAGTACAATGACAGGAAAACCATTATTTTATCATAGAACTGCGAA
CCCAAGTCCTACAATGTTTCCCTTTCAGCTCAACTGCAGAATAGTTTAGAACAGACTTTTTGATTTCACAATACTGTTTCCACACTTACT
TATATCCGTAACTTTCTAACTTTAAGGGAATTCCGCTTATTTGACATTTAACTACCTCAGATATGCCACCAAACCTGTTTTCATCATTAG
TTATTTTTACCTTGTCTACTTTAAAACAGTGAAATTATTAGGTTAAATTATGTTTTTATCCAGTTACTCTAAGATACCTTAGTGTTTGTC
TACTTATTACAACTCACCAAATTACTGGTTTTATATGGCCTTTGGGAAGGCTTTTAGCTTTTTATAAAATAATGAAGTATGCATGAAAAG
AAAGCAAATTTTAGTTGGTTGCAGTCAGAGAATATGGAAAGGGTTATTATTATAATTAGGATTTTATTATTCACATTGGAAATCACTGCT
ATGTGTTAAGGAATTGAAGGTGGCCTCTGGCTAGCAGCCATTAAGAAAATGAGCCCCTGAGTTCAACGACCCTCAAATGAAGTGAAGTCT
ACCAATAACCACTGAATAAGCTTGGAATTTTAGATTCCTTCCCAGCTGAATCTTGACTTCAGCCTTGTGAGACACCCTGAAGTAGAGGAT
GCAGCTAAATTTTGTCCAGATTACACACCCACAGAAACTGTATGATAATTAATATGTGTTGTTTAAAGTTGTTATGGTTTGGAGATATTT
GTTATGCAGCAATAGATAGCTGATACAAGGAAGTAGAGAACAAACATTTTCTATTAGTCTGTTTTCACATGGCTATAAAGAATACCACCT
GAGACTGGGTAATTTATAAAGAAAGGAGGATTAATTGACTCAGATTTCCACATGGCCTAGGAGGCCTCAGGAAACTTACAATCATGATGA
AAGAGGAAGCAGAAACATCTCATATGATGGAAGATGTGTATGAAGGAGGAACTGTCAAACACTTATAAAACCATCAGATCTCTTGAGAGC
TTACTATCTCGACAAAAGCATGGGGGAAACCACCCCCATGATCCAATCACCTCCCACCTGGTCCCTCCCTCAACATGTGGAGATTATAGC
AATTAAAAAAATGAGATTTGGGGGGATGGACACAGAGCCAAACCATATAATGTTTTAAATGCTCCAGATAGGTTTAGGTAAAATTAACTA
TATTTAATAGGCTTTCATCACTGCAAAACTTTTTTTCCTTTCTTTGTGTCTCTAGTCTCTTCCATTTGTTCTCCCTTCTTTACTAGCACC
GAGGATTTGCTTGAAATCTCTGATAGCCAGTATTCTCATTTATCATATTCTTTCTCACTTTGTGTTTCCTTGGTAATTTTGGATAACTCC
TTAAATTTATCTTCCAAATTACTGGTTTTTATATTCTGTACTGTCAGTCCTCCTGTTCACTAATTTCAAAATTTATAGTTGTTTCTCTTG
TTTACTTATATAGTTGTTTCTCTTGTTTACTTAATAACATTCTCTTCTTTCCTATCAGTTTAATTTTATAAAGGCTAACCAATTAACTGT
TTTTAACTTATATTTCCAGATATTTTAAAAATTAAAGCAAAATGTGTATAAACTTTATTACTGCTTCCCACAGTAAATATTTTTCAGAAG
TACATGCTTTCTCAGCCACTTGACTAGTATGTTCCCCATCATTCAAAGACACCATTATTTCCTAAGTGTTATATTGCTATTTTTCAGTTG
GTGCATCCAATATTATTATCAGCTTTAATATTGTTTCATCATATGTCATTGTTCAAAGAATCCATCTCTTGAGCGTAAGCTAAATAATTT
GCATACACTAGCATCTGGATGTAATATGGAAAAATATGGAAATGGTTGGGGTGATAAGCAAGTCTTGCATATTCTTTTCTCCTCAATTTT
TTTTCTCCAAAGTGGGCCAAGCCAAGAGTGGCACAGCTGTGTGGAGATACTGAGCTCCACCTTGTCAGGGAAGATCCCAACTCAGGAGAA
AACACCTCTAACAAAATCTGTAGCCACGTTGGCACATCTGCCCTTGAATTCACTTTGTCTCTTTTGCTGCTTCCATAAAAAGGCTTTCCC
TTGACAATGTTAGGCACTTTTTAGCAACTAGGCCTGGGTGGTCTGCTACAATGCCCAACACTTAATACAGTATCACTATTACTGTTAGTA
GTATGCTAAGCGAATACTATTGTTATAAAAAAAATCCTAAGCATGAAAATTACGGTATACAATTTATTGTGAAGGCAACTTCTTGTGAAC
ATTAAACGGTTTATCTCCTTCACCTCATATTAAAGTCCATACTCTTGGGATATATCTGACATCTCAATATTAAATGACTAAGATGACTAA
GTCGTTTATGTTGCTCCCACCTCACACAAAGTTAAAACTATTTGTTACTTTAAATAGTTTGACAATGTTATTTTAAAATCTGGACAAATC

>2007_2007_2_ADAM9-ADAM28_ADAM9_chr8_38871562_ENST00000487273_ADAM28_chr8_24168873_ENST00000265769_length(amino acids)=784AA_BP=111
MGSGARFPSGTLRVRWLLLLGLVGPVLGAARPGFQQTSHLSSYEIITPWRLTRERREAPRPYSKQVSYVIQAEGKEHIIHLERNKDLLPE
DFVVYTYNKEGTLITDHPNIQDDCYYQGHILNEKVSDASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGM
DGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKD
KIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDD
YSCKCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKI
KATFQCALGECCEKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGTEVADKSC
YNRNEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQGGSDNLPWKGRIVTFLTCKTFDPEDTSQEIGMVANGTKCGDNKVCINAECVDIE
KAYKSTNCSSKCKGHAVCDHELQCQCEEGWIPPDCDDSSVVFHFSIVVGVLFPMAVIFVVVAMVIRHQSSREKQKKDQRPLSTTGTRPHK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ADAM9-ADAM28


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ADAM9-ADAM28


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ADAM9-ADAM28


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADAM9C0015397Disorder of eye1GENOMICS_ENGLAND
HgeneADAM9C0033578Prostatic Neoplasms1CTD_human
HgeneADAM9C0376358Malignant neoplasm of prostate1CTD_human
HgeneADAM9C1423873CONE-ROD DYSTROPHY 91CTD_human;GENOMICS_ENGLAND
HgeneADAM9C3489532Cone-Rod Dystrophy 21ORPHANET
TgeneC0024121Lung Neoplasms1CTD_human
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0242379Malignant neoplasm of lung1CTD_human
TgeneC0376358Malignant neoplasm of prostate1CTD_human