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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ADAM9-ADAM28 (FusionGDB2 ID:HG8754TG10863)

Fusion Gene Summary for ADAM9-ADAM28

Fusion gene summary

Fusion gene information	Fusion gene name: ADAM9-ADAM28
	Fusion gene ID: hg8754tg10863
		Hgene	Tgene
	Gene symbol	ADAM9	ADAM28
	Gene ID	8754	10863
	Gene name	ADAM metallopeptidase domain 9	ADAM metallopeptidase domain 28
	Synonyms	CORD9\|MCMP\|MDC9\|Mltng	ADAM 28\|MDC-L\|MDCL\|eMDC II\|eMDCII
	Cytomap	('ADAM9')('ADAM28') 8p11.22	8p21.2
	Type of gene	protein-coding	protein-coding
	Description	disintegrin and metalloproteinase domain-containing protein 9ADAM metallopeptidase domain 9 (meltrin gamma)cellular disintegrin-related proteincone rod dystrophy 9metalloprotease/disintegrin/cysteine-rich protein 9myeloma cell metalloproteinase	disintegrin and metalloproteinase domain-containing protein 28epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein IIepididymial metalloproteinase-like, disintegrin-like, and cysteine-rich protein IIepididymis secretory sperm
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000466936, ENST00000481513, ENST00000487273, ENST00000484143,
Fusion gene scores	* DoF score	27 X 19 X 12=6156	5 X 6 X 4=120
	# samples	31	5
	** MAII score	log2(31/6156*10)=-4.31165311105397 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/120*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ADAM9 [Title/Abstract] AND ADAM28 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ADAM9(38871562)-ADAM28(24168873), # samples:1
Anticipated loss of major functional domain due to fusion event.	ADAM9-ADAM28 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ADAM9-ADAM28 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ADAM9-ADAM28 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ADAM9-ADAM28 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ADAM9-ADAM28 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. ADAM9-ADAM28 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ADAM9	GO:0000186	activation of MAPKK activity	17704059
Hgene	ADAM9	GO:0006509	membrane protein ectodomain proteolysis	9920899
Hgene	ADAM9	GO:0034612	response to tumor necrosis factor	11831872
Hgene	ADAM9	GO:0050714	positive regulation of protein secretion	17704059

Fusion gene breakpoints across ADAM9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ADAM28 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	2397N	ADAM9	chr8	38871562	+	ADAM28	chr8	24168873	+

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Fusion Gene ORF analysis for ADAM9-ADAM28

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000466936	ENST00000397649	ADAM9	chr8	38871562	+	ADAM28	chr8	24168873	+
5CDS-5UTR	ENST00000466936	ENST00000437154	ADAM9	chr8	38871562	+	ADAM28	chr8	24168873	+
5CDS-5UTR	ENST00000466936	ENST00000540823	ADAM9	chr8	38871562	+	ADAM28	chr8	24168873	+
5CDS-5UTR	ENST00000481513	ENST00000397649	ADAM9	chr8	38871562	+	ADAM28	chr8	24168873	+
5CDS-5UTR	ENST00000481513	ENST00000437154	ADAM9	chr8	38871562	+	ADAM28	chr8	24168873	+
5CDS-5UTR	ENST00000481513	ENST00000540823	ADAM9	chr8	38871562	+	ADAM28	chr8	24168873	+
5CDS-5UTR	ENST00000487273	ENST00000397649	ADAM9	chr8	38871562	+	ADAM28	chr8	24168873	+
5CDS-5UTR	ENST00000487273	ENST00000437154	ADAM9	chr8	38871562	+	ADAM28	chr8	24168873	+
5CDS-5UTR	ENST00000487273	ENST00000540823	ADAM9	chr8	38871562	+	ADAM28	chr8	24168873	+
5CDS-intron	ENST00000466936	ENST00000518516	ADAM9	chr8	38871562	+	ADAM28	chr8	24168873	+
5CDS-intron	ENST00000481513	ENST00000518516	ADAM9	chr8	38871562	+	ADAM28	chr8	24168873	+
5CDS-intron	ENST00000487273	ENST00000518516	ADAM9	chr8	38871562	+	ADAM28	chr8	24168873	+
Frame-shift	ENST00000481513	ENST00000265769	ADAM9	chr8	38871562	+	ADAM28	chr8	24168873	+
In-frame	ENST00000466936	ENST00000265769	ADAM9	chr8	38871562	+	ADAM28	chr8	24168873	+
In-frame	ENST00000487273	ENST00000265769	ADAM9	chr8	38871562	+	ADAM28	chr8	24168873	+
intron-3CDS	ENST00000484143	ENST00000265769	ADAM9	chr8	38871562	+	ADAM28	chr8	24168873	+
intron-5UTR	ENST00000484143	ENST00000397649	ADAM9	chr8	38871562	+	ADAM28	chr8	24168873	+
intron-5UTR	ENST00000484143	ENST00000437154	ADAM9	chr8	38871562	+	ADAM28	chr8	24168873	+
intron-5UTR	ENST00000484143	ENST00000540823	ADAM9	chr8	38871562	+	ADAM28	chr8	24168873	+
intron-intron	ENST00000484143	ENST00000518516	ADAM9	chr8	38871562	+	ADAM28	chr8	24168873	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000487273

ADAM9

chr8

38871562

ENST00000265769

ADAM28

chr8

24168873

7047

411

2432

784

ENST00000466936

ADAM9

chr8

38871562

ENST00000265769

ADAM28

chr8

24168873

7164

528

195

2549

784

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000487273	ENST00000265769	ADAM9	chr8	38871562	+	ADAM28	chr8	24168873	+	3.06E-05	0.99996936
ENST00000466936	ENST00000265769	ADAM9	chr8	38871562	+	ADAM28	chr8	24168873	+	3.02E-05	0.9999697

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Fusion Genomic Features for ADAM9-ADAM28

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ADAM9	chr8	38871562	+	ADAM28	chr8	24168873	+	7.04E-06	0.99999297
ADAM9	chr8	38871562	+	ADAM28	chr8	24168873	+	7.04E-06	0.99999297

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ADAM9-ADAM28

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:38871562/chr8:24168873)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ADAM28

chr8:38871562

chr8:24168873

ENST00000265769

494_628

102

776.0

Compositional bias

Note=Cys-rich

Tgene

ADAM28

chr8:38871562

chr8:24168873

ENST00000437154

494_628

102

541.0

Compositional bias

Note=Cys-rich

Tgene

ADAM28

chr8:38871562

chr8:24168873

ENST00000265769

204_399

102

776.0

Domain

Peptidase M12B

Tgene

ADAM28

chr8:38871562

chr8:24168873

ENST00000265769

407_493

102

776.0

Domain

Disintegrin

Tgene

ADAM28

chr8:38871562

chr8:24168873

ENST00000265769

625_657

102

776.0

Domain

EGF-like

Tgene

ADAM28

chr8:38871562

chr8:24168873

ENST00000437154

204_399

102

541.0

Domain

Peptidase M12B

Tgene

ADAM28

chr8:38871562

chr8:24168873

ENST00000437154

407_493

102

541.0

Domain

Disintegrin

Tgene

ADAM28

chr8:38871562

chr8:24168873

ENST00000437154

625_657

102

541.0

Domain

EGF-like

Tgene

ADAM28

chr8:38871562

chr8:24168873

ENST00000265769

167_174

102

776.0

Motif

Cysteine switch

Tgene

ADAM28

chr8:38871562

chr8:24168873

ENST00000437154

167_174

102

541.0

Motif

Cysteine switch

Tgene

ADAM28

chr8:38871562

chr8:24168873

ENST00000265769

199_665

102

776.0

Topological domain

Extracellular

Tgene

ADAM28

chr8:38871562

chr8:24168873

ENST00000265769

687_775

102

776.0

Topological domain

Cytoplasmic

Tgene

ADAM28

chr8:38871562

chr8:24168873

ENST00000437154

199_665

102

541.0

Topological domain

Extracellular

Tgene

ADAM28

chr8:38871562

chr8:24168873

ENST00000437154

687_775

102

541.0

Topological domain

Cytoplasmic

Tgene

ADAM28

chr8:38871562

chr8:24168873

ENST00000265769

666_686

102

776.0

Transmembrane

Helical

Tgene

ADAM28

chr8:38871562

chr8:24168873

ENST00000437154

666_686

102

541.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ADAM9

chr8:38871562

chr8:24168873

ENST00000487273

505_634

111

820.0

Compositional bias

Note=Cys-rich

Hgene

ADAM9

chr8:38871562

chr8:24168873

ENST00000487273

790_795

111

820.0

Compositional bias

Note=Poly-Pro

Hgene

ADAM9

chr8:38871562

chr8:24168873

ENST00000487273

212_406

111

820.0

Domain

Peptidase M12B

Hgene

ADAM9

chr8:38871562

chr8:24168873

ENST00000487273

414_501

111

820.0

Domain

Disintegrin

Hgene

ADAM9

chr8:38871562

chr8:24168873

ENST00000487273

644_698

111

820.0

Domain

EGF-like

Hgene

ADAM9

chr8:38871562

chr8:24168873

ENST00000487273

29_697

111

820.0

Topological domain

Extracellular

Hgene

ADAM9

chr8:38871562

chr8:24168873

ENST00000487273

719_819

111

820.0

Topological domain

Cytoplasmic

Hgene

ADAM9

chr8:38871562

chr8:24168873

ENST00000487273

698_718

111

820.0

Transmembrane

Helical

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Fusion Gene Sequence for ADAM9-ADAM28

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>2007_2007_1_ADAM9-ADAM28_ADAM9_chr8_38871562_ENST00000466936_ADAM28_chr8_24168873_ENST00000265769_length(transcript)=7164nt_BP=528nt
TAGGCGATGTCGGGAGCGAGCTCGGACCGAGGGCTCAGTTGCGTCAGTGCCGCGCGCGTGCTCGTCGGGCGCGCGTGCTCGTCGGGCGCG
CGCGCTTCCCGGCCAGACTTGGGGCCCCGGCAGGGTTGGAAAATGATGGAAGAGGCGGAGGTGGAGGCGACCGAGTGCTGAGAGGAACCT
GCGGAATCGGCCGAGATGGGGTCTGGCGCGCGCTTTCCCTCGGGGACCCTTCGTGTCCGGTGGTTGCTGTTGCTTGGCCTGGTGGGCCCA
GTCCTCGGTGCGGCGCGGCCAGGCTTTCAACAGACCTCACATCTTTCTTCTTATGAAATTATAACTCCTTGGAGATTAACTAGAGAAAGA
AGAGAAGCCCCTAGGCCCTATTCAAAACAAGTATCTTATGTTATTCAGGCTGAAGGAAAAGAGCATATTATTCACTTGGAAAGGAACAAA
GACCTTTTGCCTGAAGATTTTGTGGTTTATACTTACAACAAGGAAGGGACTTTAATCACTGACCATCCCAATATACAGGATGATTGTTAT
TATCAAGGACATATTCTTAATGAAAAGGTTTCTGACGCTAGCATCAGCACATGTAGGGGTCTAAGGGGCTACTTCAGTCAGGGGGATCAA
AGATACTTTATTGAACCTTTAAGCCCCATACATCGGGATGGACAGGAGCATGCACTCTTCAAGTATAACCCTGATGAAAAGAATTATGAC
AGCACCTGTGGGATGGATGGTGTGTTGTGGGCCCACGATTTGCAGCAGAACATTGCCCTACCTGCCACCAAACTAGTAAAATTGAAAGAC
AGGAAGGTTCAGGAACATGAGAAATACATAGAATATTATTTGGTCCTGGATAATGGTGAGTTTAAAAGGTACAATGAGAATCAAGATGAG
ATCAGAAAGAGGGTATTTGAGATGGCTAATTATGTCAACATGCTTTATAAAAAGCTCAATACTCATGTGGCCTTAGTTGGTATGGAAATC
TGGACTGACAAGGATAAGATAAAGATAACCCCAAATGCAAGCTTCACCTTGGAGAATTTTTCTAAATGGAGGGGGAGTGTTCTCTCAAGA
AGAAAGCGTCATGATATTGCTCAGTTAATCACAGCAACAGAACTTGCTGGAACGACTGTGGGTCTTGCATTTATGTCTACAATGTGTTCT
CCTTATTCTGTTGGCGTTGTTCAGGACCACAGCGATAATCTTCTTAGAGTTGCAGGGACAATGGCACATGAAATGGGCCACAACTTTGGA
ATGTTTCATGACGACTATTCTTGCAAGTGTCCTTCTACAATATGTGTGATGGACAAAGCACTGAGCTTCTATATACCCACAGACTTCAGT
TCCTGCAGCCGTCTCAGCTATGACAAGTTTTTTGAAGATAAATTATCAAATTGCCTCTTTAATGCTCCATTGCCTACAGATATCATATCC
ACTCCAATTTGTGGGAACCAGTTGGTGGAAATGGGAGAGGACTGTGATTGTGGGACATCTGAGGAATGTACCAATATTTGCTGTGATGCT
AAGACATGTAAAATCAAAGCAACTTTTCAATGTGCATTAGGAGAATGTTGTGAAAAATGCCAATTTAAAAAGGCTGGGATGGTGTGCAGA
CCAGCAAAAGATGAGTGCGACCTGCCTGAAATGTGTAATGGTAAATCTGGTAATTGTCCTGATGATAGATTCCAAGTCAATGGCTTCCCT
TGCCATCACGGGAAGGGCCACTGCTTGATGGGGACATGCCCCACACTGCAGGAGCAGTGCACAGAGCTGTGGGGACCAGGAACTGAGGTT
GCAGATAAGTCATGTTACAACAGGAATGAAGGTGGGTCAAAGTACGGGTACTGTCGCAGAGTGGATGACACACTCATTCCCTGCAAAGCA
AATGATACCATGTGTGGGAAGTTGTTCTGTCAAGGTGGGTCGGATAATTTGCCCTGGAAAGGACGGATAGTGACTTTCCTGACATGTAAA
ACATTTGATCCTGAAGACACAAGTCAAGAAATAGGCATGGTGGCCAATGGAACTAAGTGTGGCGATAACAAGGTTTGCATTAATGCAGAA
TGTGTGGATATTGAGAAAGCCTACAAATCAACCAATTGCTCATCTAAGTGCAAAGGACATGCTGTGTGTGACCATGAGCTCCAGTGTCAA
TGTGAGGAAGGATGGATCCCTCCCGACTGCGATGACTCCTCAGTGGTCTTCCACTTCTCCATTGTGGTTGGGGTGCTGTTCCCAATGGCG
GTCATTTTTGTGGTGGTTGCTATGGTAATCCGGCACCAGAGCTCCAGAGAAAAGCAGAAGAAAGATCAGAGGCCACTATCTACCACTGGC
ACCAGGCCACACAAACAGAAGAGGAAACCCCAGATGGTAAAGGCTGTTCAACCCCAAGAGATGAGTCAGATGAAGCCCCATGTGTATGAT
CTGCCAGTAGAAGGCAATGAGCCCCCAGCCTCTTTTCATAAAGACACAAACGCACTTCCCCCTACTGTTTTCAAGGATAATCCAGTGTCT
ACACCTAAGGACTCAAATCCAAAAGCATGAAGCAACAGCTAAGCAAGAACTAATGGCTAAATTATCAACTTGGAAAACTGGAAAATCTGG
ATGGCAGAGAAATATACTATCTATCTCACCAGTATTTGCTCTCGACTCAAGAAGGTTAACATTTTCTGATTCATGTTAGACTTTGAAGAG
ACTAAAGAAAATTTTCAAGAGGAACATATGCCTGAGAACCTTTGCATGAATTTAAAATTTCAATTATCCATTCTTATAAGAAGGAAGATG
ATTGTAAAGAAATATCTCCGAAGTTAAAATCTGTAATAGGAATTGATTCATTCTCTAATGAAAACAAAACATAAAAACATCACACTAATC
TTGGAGGAATAAGAAAAATTGTACATCCATTAAATGTACAATTGATTGCAACATCTTGATTGTTTTAACCATTAACTTGTCAAATTACAA
TCACAGTTAAGAAAATGATGTAAAATTCTGTTTTGTGGATCTCTTTCCTAGATTAGCTTCTGAAATCATTATTAGCTATATCATTTGAGG
TTTTCTACAATTTGGTATAACTAAGAATTTAAAAATGTTTTATCATATATATTTGTATAATTAATTACTGGCATGGTTAAAGTGGTTTTC
ACTTTTTAAATGGAGAAAATTTCAGTTAAATTAATAGGATAAACCAGGTTGCGAACTGGTGACCTGTAGGCCATGTTTGCACTGCAAATA
TATTTGGTCTGAATGATATTGATATTGGACACATAGTACTTTTACATGTTTTGAATGTATTGCTAATATTTAAAAATTGAGAGATCTTGC
ATAAACAATAGATTCCCAGCTTTGTCAGATGTAATCTAAAAGTAATCCGATGCTTTGTCAACAACAGACTTACATTGCCCATAGCAACCG
TCAGCTTAGTTGATGGGTAATGTAGCAAACACTATTGGTTTCCTACCAAATAATCCCCTTTTTCCTGGCTTTTAGAACAATAATTTTGTT
CACCTGCCCACTTCTAGGAAAGAATATCCTATCTAATCTATCTATCTCAGGGATAAATCCCTATCCTTTTAAGTAAGTCAAGTCAATTAA
AATAACCTCATTTTTCCTTGCTAGTGGTCGACTTGGAGATGATTTTATAATCCTCCCCCTCCCTTTTTTTTTTTGCTAGTAAGACGACAG
AGGAATTATGTTACAACACTTCTGGAAAATTTTTCCTCGTCTCTTTTTCTGGATATGGGCATCTGAATACTCTAGCTGGTACTGCTGCGC
TCCACACGGTGATTATGAAGGCTGAAAAAGATAGATAGAGCAGAAAGATGAAAAGAATAAAACCTGGCCTTTCAATGATGTCATGGAATT
GGTAGATCAGTGACTGCTGGAGTTACCTCACACTTTCTTGGTACTCCTTATTATATGAGCCATACATTTTCCTTGTTGTTTAAGCCATTT
TGAATTGGATTTTCTCTCACTTTCAACAGAGATCATCCTAACTAGTAAAGTAGCTGTTTCCATAATCAGGGAACATGCTTTAGTTCATCA
TCACAGCTACAGTTTTTCTTGTATTTGTCTGCTTCACCCATTTCTATCAATCACTTACCTGGTCCCCACAGGCCTGTCGCTTCATGAGGA
ACTTTATGGTTCATTTACCCTTGCAGTATGAGGTTCTAGATAAGCCCACTCTGGCCTCAAAAGTGAAGCTCAGTCCTCAGGAAATCCAGA
GTCCACTGATCAAATCACTGTCAAGGATACAGGCTTTTTCTCCATGTGGCATTTGCAGAAGAACAACTTTAAAAGTAGAGCTTTATCTGC
CCTGTGAGGTTTCAGAAGACCCTCCCCTGACCCAGAAATAAATCCCTATTTCCTGGAAAGCCATTATGTACTCGTGACCAACTTGTGAAC
TTTTCTGTGTTGTTGTTGTTGTTTTTTAAATATCTGTCCCCAGTAATAGATTCACCTAATCCTTTTTTATACTGATGGAATGGAAATCTT
AAATCTATGAATCCTCAACTAGCCATGTACCATAACCCAAGCAAAAACTAAACCATACACTCTCAAAAGCAGTGGCATGTGAACATGCCT
GCAAGTTCCTAAATGATGTCACTAGGTCCCTGATGCAGATGCATCATACGTCCTATTTGAAGAGAAGAAATGCAGTACAATGACAGGAAA
ACCATTATTTTATCATAGAACTGCGAACCCAAGTCCTACAATGTTTCCCTTTCAGCTCAACTGCAGAATAGTTTAGAACAGACTTTTTGA
TTTCACAATACTGTTTCCACACTTACTTATATCCGTAACTTTCTAACTTTAAGGGAATTCCGCTTATTTGACATTTAACTACCTCAGATA
TGCCACCAAACCTGTTTTCATCATTAGTTATTTTTACCTTGTCTACTTTAAAACAGTGAAATTATTAGGTTAAATTATGTTTTTATCCAG
TTACTCTAAGATACCTTAGTGTTTGTCTACTTATTACAACTCACCAAATTACTGGTTTTATATGGCCTTTGGGAAGGCTTTTAGCTTTTT
ATAAAATAATGAAGTATGCATGAAAAGAAAGCAAATTTTAGTTGGTTGCAGTCAGAGAATATGGAAAGGGTTATTATTATAATTAGGATT
TTATTATTCACATTGGAAATCACTGCTATGTGTTAAGGAATTGAAGGTGGCCTCTGGCTAGCAGCCATTAAGAAAATGAGCCCCTGAGTT
CAACGACCCTCAAATGAAGTGAAGTCTACCAATAACCACTGAATAAGCTTGGAATTTTAGATTCCTTCCCAGCTGAATCTTGACTTCAGC
CTTGTGAGACACCCTGAAGTAGAGGATGCAGCTAAATTTTGTCCAGATTACACACCCACAGAAACTGTATGATAATTAATATGTGTTGTT
TAAAGTTGTTATGGTTTGGAGATATTTGTTATGCAGCAATAGATAGCTGATACAAGGAAGTAGAGAACAAACATTTTCTATTAGTCTGTT
TTCACATGGCTATAAAGAATACCACCTGAGACTGGGTAATTTATAAAGAAAGGAGGATTAATTGACTCAGATTTCCACATGGCCTAGGAG
GCCTCAGGAAACTTACAATCATGATGAAAGAGGAAGCAGAAACATCTCATATGATGGAAGATGTGTATGAAGGAGGAACTGTCAAACACT
TATAAAACCATCAGATCTCTTGAGAGCTTACTATCTCGACAAAAGCATGGGGGAAACCACCCCCATGATCCAATCACCTCCCACCTGGTC
CCTCCCTCAACATGTGGAGATTATAGCAATTAAAAAAATGAGATTTGGGGGGATGGACACAGAGCCAAACCATATAATGTTTTAAATGCT
CCAGATAGGTTTAGGTAAAATTAACTATATTTAATAGGCTTTCATCACTGCAAAACTTTTTTTCCTTTCTTTGTGTCTCTAGTCTCTTCC
ATTTGTTCTCCCTTCTTTACTAGCACCGAGGATTTGCTTGAAATCTCTGATAGCCAGTATTCTCATTTATCATATTCTTTCTCACTTTGT
GTTTCCTTGGTAATTTTGGATAACTCCTTAAATTTATCTTCCAAATTACTGGTTTTTATATTCTGTACTGTCAGTCCTCCTGTTCACTAA
TTTCAAAATTTATAGTTGTTTCTCTTGTTTACTTATATAGTTGTTTCTCTTGTTTACTTAATAACATTCTCTTCTTTCCTATCAGTTTAA
TTTTATAAAGGCTAACCAATTAACTGTTTTTAACTTATATTTCCAGATATTTTAAAAATTAAAGCAAAATGTGTATAAACTTTATTACTG
CTTCCCACAGTAAATATTTTTCAGAAGTACATGCTTTCTCAGCCACTTGACTAGTATGTTCCCCATCATTCAAAGACACCATTATTTCCT
AAGTGTTATATTGCTATTTTTCAGTTGGTGCATCCAATATTATTATCAGCTTTAATATTGTTTCATCATATGTCATTGTTCAAAGAATCC
ATCTCTTGAGCGTAAGCTAAATAATTTGCATACACTAGCATCTGGATGTAATATGGAAAAATATGGAAATGGTTGGGGTGATAAGCAAGT
CTTGCATATTCTTTTCTCCTCAATTTTTTTTCTCCAAAGTGGGCCAAGCCAAGAGTGGCACAGCTGTGTGGAGATACTGAGCTCCACCTT
GTCAGGGAAGATCCCAACTCAGGAGAAAACACCTCTAACAAAATCTGTAGCCACGTTGGCACATCTGCCCTTGAATTCACTTTGTCTCTT
TTGCTGCTTCCATAAAAAGGCTTTCCCTTGACAATGTTAGGCACTTTTTAGCAACTAGGCCTGGGTGGTCTGCTACAATGCCCAACACTT
AATACAGTATCACTATTACTGTTAGTAGTATGCTAAGCGAATACTATTGTTATAAAAAAAATCCTAAGCATGAAAATTACGGTATACAAT
TTATTGTGAAGGCAACTTCTTGTGAACATTAAACGGTTTATCTCCTTCACCTCATATTAAAGTCCATACTCTTGGGATATATCTGACATC
TCAATATTAAATGACTAAGATGACTAAGTCGTTTATGTTGCTCCCACCTCACACAAAGTTAAAACTATTTGTTACTTTAAATAGTTTGAC

>2007_2007_1_ADAM9-ADAM28_ADAM9_chr8_38871562_ENST00000466936_ADAM28_chr8_24168873_ENST00000265769_length(amino acids)=784AA_BP=111
MGSGARFPSGTLRVRWLLLLGLVGPVLGAARPGFQQTSHLSSYEIITPWRLTRERREAPRPYSKQVSYVIQAEGKEHIIHLERNKDLLPE
DFVVYTYNKEGTLITDHPNIQDDCYYQGHILNEKVSDASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGM
DGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKD
KIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDD
YSCKCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKI
KATFQCALGECCEKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGTEVADKSC
YNRNEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQGGSDNLPWKGRIVTFLTCKTFDPEDTSQEIGMVANGTKCGDNKVCINAECVDIE
KAYKSTNCSSKCKGHAVCDHELQCQCEEGWIPPDCDDSSVVFHFSIVVGVLFPMAVIFVVVAMVIRHQSSREKQKKDQRPLSTTGTRPHK

--------------------------------------------------------------
>2007_2007_2_ADAM9-ADAM28_ADAM9_chr8_38871562_ENST00000487273_ADAM28_chr8_24168873_ENST00000265769_length(transcript)=7047nt_BP=411nt
CGGCAGGGTTGGAAAATGATGGAAGAGGCGGAGGTGGAGGCGACCGAGTGCTGAGAGGAACCTGCGGAATCGGCCGAGATGGGGTCTGGC
GCGCGCTTTCCCTCGGGGACCCTTCGTGTCCGGTGGTTGCTGTTGCTTGGCCTGGTGGGCCCAGTCCTCGGTGCGGCGCGGCCAGGCTTT
CAACAGACCTCACATCTTTCTTCTTATGAAATTATAACTCCTTGGAGATTAACTAGAGAAAGAAGAGAAGCCCCTAGGCCCTATTCAAAA
CAAGTATCTTATGTTATTCAGGCTGAAGGAAAAGAGCATATTATTCACTTGGAAAGGAACAAAGACCTTTTGCCTGAAGATTTTGTGGTT
TATACTTACAACAAGGAAGGGACTTTAATCACTGACCATCCCAATATACAGGATGATTGTTATTATCAAGGACATATTCTTAATGAAAAG
GTTTCTGACGCTAGCATCAGCACATGTAGGGGTCTAAGGGGCTACTTCAGTCAGGGGGATCAAAGATACTTTATTGAACCTTTAAGCCCC
ATACATCGGGATGGACAGGAGCATGCACTCTTCAAGTATAACCCTGATGAAAAGAATTATGACAGCACCTGTGGGATGGATGGTGTGTTG
TGGGCCCACGATTTGCAGCAGAACATTGCCCTACCTGCCACCAAACTAGTAAAATTGAAAGACAGGAAGGTTCAGGAACATGAGAAATAC
ATAGAATATTATTTGGTCCTGGATAATGGTGAGTTTAAAAGGTACAATGAGAATCAAGATGAGATCAGAAAGAGGGTATTTGAGATGGCT
AATTATGTCAACATGCTTTATAAAAAGCTCAATACTCATGTGGCCTTAGTTGGTATGGAAATCTGGACTGACAAGGATAAGATAAAGATA
ACCCCAAATGCAAGCTTCACCTTGGAGAATTTTTCTAAATGGAGGGGGAGTGTTCTCTCAAGAAGAAAGCGTCATGATATTGCTCAGTTA
ATCACAGCAACAGAACTTGCTGGAACGACTGTGGGTCTTGCATTTATGTCTACAATGTGTTCTCCTTATTCTGTTGGCGTTGTTCAGGAC
CACAGCGATAATCTTCTTAGAGTTGCAGGGACAATGGCACATGAAATGGGCCACAACTTTGGAATGTTTCATGACGACTATTCTTGCAAG
TGTCCTTCTACAATATGTGTGATGGACAAAGCACTGAGCTTCTATATACCCACAGACTTCAGTTCCTGCAGCCGTCTCAGCTATGACAAG
TTTTTTGAAGATAAATTATCAAATTGCCTCTTTAATGCTCCATTGCCTACAGATATCATATCCACTCCAATTTGTGGGAACCAGTTGGTG
GAAATGGGAGAGGACTGTGATTGTGGGACATCTGAGGAATGTACCAATATTTGCTGTGATGCTAAGACATGTAAAATCAAAGCAACTTTT
CAATGTGCATTAGGAGAATGTTGTGAAAAATGCCAATTTAAAAAGGCTGGGATGGTGTGCAGACCAGCAAAAGATGAGTGCGACCTGCCT
GAAATGTGTAATGGTAAATCTGGTAATTGTCCTGATGATAGATTCCAAGTCAATGGCTTCCCTTGCCATCACGGGAAGGGCCACTGCTTG
ATGGGGACATGCCCCACACTGCAGGAGCAGTGCACAGAGCTGTGGGGACCAGGAACTGAGGTTGCAGATAAGTCATGTTACAACAGGAAT
GAAGGTGGGTCAAAGTACGGGTACTGTCGCAGAGTGGATGACACACTCATTCCCTGCAAAGCAAATGATACCATGTGTGGGAAGTTGTTC
TGTCAAGGTGGGTCGGATAATTTGCCCTGGAAAGGACGGATAGTGACTTTCCTGACATGTAAAACATTTGATCCTGAAGACACAAGTCAA
GAAATAGGCATGGTGGCCAATGGAACTAAGTGTGGCGATAACAAGGTTTGCATTAATGCAGAATGTGTGGATATTGAGAAAGCCTACAAA
TCAACCAATTGCTCATCTAAGTGCAAAGGACATGCTGTGTGTGACCATGAGCTCCAGTGTCAATGTGAGGAAGGATGGATCCCTCCCGAC
TGCGATGACTCCTCAGTGGTCTTCCACTTCTCCATTGTGGTTGGGGTGCTGTTCCCAATGGCGGTCATTTTTGTGGTGGTTGCTATGGTA
ATCCGGCACCAGAGCTCCAGAGAAAAGCAGAAGAAAGATCAGAGGCCACTATCTACCACTGGCACCAGGCCACACAAACAGAAGAGGAAA
CCCCAGATGGTAAAGGCTGTTCAACCCCAAGAGATGAGTCAGATGAAGCCCCATGTGTATGATCTGCCAGTAGAAGGCAATGAGCCCCCA
GCCTCTTTTCATAAAGACACAAACGCACTTCCCCCTACTGTTTTCAAGGATAATCCAGTGTCTACACCTAAGGACTCAAATCCAAAAGCA
TGAAGCAACAGCTAAGCAAGAACTAATGGCTAAATTATCAACTTGGAAAACTGGAAAATCTGGATGGCAGAGAAATATACTATCTATCTC
ACCAGTATTTGCTCTCGACTCAAGAAGGTTAACATTTTCTGATTCATGTTAGACTTTGAAGAGACTAAAGAAAATTTTCAAGAGGAACAT
ATGCCTGAGAACCTTTGCATGAATTTAAAATTTCAATTATCCATTCTTATAAGAAGGAAGATGATTGTAAAGAAATATCTCCGAAGTTAA
AATCTGTAATAGGAATTGATTCATTCTCTAATGAAAACAAAACATAAAAACATCACACTAATCTTGGAGGAATAAGAAAAATTGTACATC
CATTAAATGTACAATTGATTGCAACATCTTGATTGTTTTAACCATTAACTTGTCAAATTACAATCACAGTTAAGAAAATGATGTAAAATT
CTGTTTTGTGGATCTCTTTCCTAGATTAGCTTCTGAAATCATTATTAGCTATATCATTTGAGGTTTTCTACAATTTGGTATAACTAAGAA
TTTAAAAATGTTTTATCATATATATTTGTATAATTAATTACTGGCATGGTTAAAGTGGTTTTCACTTTTTAAATGGAGAAAATTTCAGTT
AAATTAATAGGATAAACCAGGTTGCGAACTGGTGACCTGTAGGCCATGTTTGCACTGCAAATATATTTGGTCTGAATGATATTGATATTG
GACACATAGTACTTTTACATGTTTTGAATGTATTGCTAATATTTAAAAATTGAGAGATCTTGCATAAACAATAGATTCCCAGCTTTGTCA
GATGTAATCTAAAAGTAATCCGATGCTTTGTCAACAACAGACTTACATTGCCCATAGCAACCGTCAGCTTAGTTGATGGGTAATGTAGCA
AACACTATTGGTTTCCTACCAAATAATCCCCTTTTTCCTGGCTTTTAGAACAATAATTTTGTTCACCTGCCCACTTCTAGGAAAGAATAT
CCTATCTAATCTATCTATCTCAGGGATAAATCCCTATCCTTTTAAGTAAGTCAAGTCAATTAAAATAACCTCATTTTTCCTTGCTAGTGG
TCGACTTGGAGATGATTTTATAATCCTCCCCCTCCCTTTTTTTTTTTGCTAGTAAGACGACAGAGGAATTATGTTACAACACTTCTGGAA
AATTTTTCCTCGTCTCTTTTTCTGGATATGGGCATCTGAATACTCTAGCTGGTACTGCTGCGCTCCACACGGTGATTATGAAGGCTGAAA
AAGATAGATAGAGCAGAAAGATGAAAAGAATAAAACCTGGCCTTTCAATGATGTCATGGAATTGGTAGATCAGTGACTGCTGGAGTTACC
TCACACTTTCTTGGTACTCCTTATTATATGAGCCATACATTTTCCTTGTTGTTTAAGCCATTTTGAATTGGATTTTCTCTCACTTTCAAC
AGAGATCATCCTAACTAGTAAAGTAGCTGTTTCCATAATCAGGGAACATGCTTTAGTTCATCATCACAGCTACAGTTTTTCTTGTATTTG
TCTGCTTCACCCATTTCTATCAATCACTTACCTGGTCCCCACAGGCCTGTCGCTTCATGAGGAACTTTATGGTTCATTTACCCTTGCAGT
ATGAGGTTCTAGATAAGCCCACTCTGGCCTCAAAAGTGAAGCTCAGTCCTCAGGAAATCCAGAGTCCACTGATCAAATCACTGTCAAGGA
TACAGGCTTTTTCTCCATGTGGCATTTGCAGAAGAACAACTTTAAAAGTAGAGCTTTATCTGCCCTGTGAGGTTTCAGAAGACCCTCCCC
TGACCCAGAAATAAATCCCTATTTCCTGGAAAGCCATTATGTACTCGTGACCAACTTGTGAACTTTTCTGTGTTGTTGTTGTTGTTTTTT
AAATATCTGTCCCCAGTAATAGATTCACCTAATCCTTTTTTATACTGATGGAATGGAAATCTTAAATCTATGAATCCTCAACTAGCCATG
TACCATAACCCAAGCAAAAACTAAACCATACACTCTCAAAAGCAGTGGCATGTGAACATGCCTGCAAGTTCCTAAATGATGTCACTAGGT
CCCTGATGCAGATGCATCATACGTCCTATTTGAAGAGAAGAAATGCAGTACAATGACAGGAAAACCATTATTTTATCATAGAACTGCGAA
CCCAAGTCCTACAATGTTTCCCTTTCAGCTCAACTGCAGAATAGTTTAGAACAGACTTTTTGATTTCACAATACTGTTTCCACACTTACT
TATATCCGTAACTTTCTAACTTTAAGGGAATTCCGCTTATTTGACATTTAACTACCTCAGATATGCCACCAAACCTGTTTTCATCATTAG
TTATTTTTACCTTGTCTACTTTAAAACAGTGAAATTATTAGGTTAAATTATGTTTTTATCCAGTTACTCTAAGATACCTTAGTGTTTGTC
TACTTATTACAACTCACCAAATTACTGGTTTTATATGGCCTTTGGGAAGGCTTTTAGCTTTTTATAAAATAATGAAGTATGCATGAAAAG
AAAGCAAATTTTAGTTGGTTGCAGTCAGAGAATATGGAAAGGGTTATTATTATAATTAGGATTTTATTATTCACATTGGAAATCACTGCT
ATGTGTTAAGGAATTGAAGGTGGCCTCTGGCTAGCAGCCATTAAGAAAATGAGCCCCTGAGTTCAACGACCCTCAAATGAAGTGAAGTCT
ACCAATAACCACTGAATAAGCTTGGAATTTTAGATTCCTTCCCAGCTGAATCTTGACTTCAGCCTTGTGAGACACCCTGAAGTAGAGGAT
GCAGCTAAATTTTGTCCAGATTACACACCCACAGAAACTGTATGATAATTAATATGTGTTGTTTAAAGTTGTTATGGTTTGGAGATATTT
GTTATGCAGCAATAGATAGCTGATACAAGGAAGTAGAGAACAAACATTTTCTATTAGTCTGTTTTCACATGGCTATAAAGAATACCACCT
GAGACTGGGTAATTTATAAAGAAAGGAGGATTAATTGACTCAGATTTCCACATGGCCTAGGAGGCCTCAGGAAACTTACAATCATGATGA
AAGAGGAAGCAGAAACATCTCATATGATGGAAGATGTGTATGAAGGAGGAACTGTCAAACACTTATAAAACCATCAGATCTCTTGAGAGC
TTACTATCTCGACAAAAGCATGGGGGAAACCACCCCCATGATCCAATCACCTCCCACCTGGTCCCTCCCTCAACATGTGGAGATTATAGC
AATTAAAAAAATGAGATTTGGGGGGATGGACACAGAGCCAAACCATATAATGTTTTAAATGCTCCAGATAGGTTTAGGTAAAATTAACTA
TATTTAATAGGCTTTCATCACTGCAAAACTTTTTTTCCTTTCTTTGTGTCTCTAGTCTCTTCCATTTGTTCTCCCTTCTTTACTAGCACC
GAGGATTTGCTTGAAATCTCTGATAGCCAGTATTCTCATTTATCATATTCTTTCTCACTTTGTGTTTCCTTGGTAATTTTGGATAACTCC
TTAAATTTATCTTCCAAATTACTGGTTTTTATATTCTGTACTGTCAGTCCTCCTGTTCACTAATTTCAAAATTTATAGTTGTTTCTCTTG
TTTACTTATATAGTTGTTTCTCTTGTTTACTTAATAACATTCTCTTCTTTCCTATCAGTTTAATTTTATAAAGGCTAACCAATTAACTGT
TTTTAACTTATATTTCCAGATATTTTAAAAATTAAAGCAAAATGTGTATAAACTTTATTACTGCTTCCCACAGTAAATATTTTTCAGAAG
TACATGCTTTCTCAGCCACTTGACTAGTATGTTCCCCATCATTCAAAGACACCATTATTTCCTAAGTGTTATATTGCTATTTTTCAGTTG
GTGCATCCAATATTATTATCAGCTTTAATATTGTTTCATCATATGTCATTGTTCAAAGAATCCATCTCTTGAGCGTAAGCTAAATAATTT
GCATACACTAGCATCTGGATGTAATATGGAAAAATATGGAAATGGTTGGGGTGATAAGCAAGTCTTGCATATTCTTTTCTCCTCAATTTT
TTTTCTCCAAAGTGGGCCAAGCCAAGAGTGGCACAGCTGTGTGGAGATACTGAGCTCCACCTTGTCAGGGAAGATCCCAACTCAGGAGAA
AACACCTCTAACAAAATCTGTAGCCACGTTGGCACATCTGCCCTTGAATTCACTTTGTCTCTTTTGCTGCTTCCATAAAAAGGCTTTCCC
TTGACAATGTTAGGCACTTTTTAGCAACTAGGCCTGGGTGGTCTGCTACAATGCCCAACACTTAATACAGTATCACTATTACTGTTAGTA
GTATGCTAAGCGAATACTATTGTTATAAAAAAAATCCTAAGCATGAAAATTACGGTATACAATTTATTGTGAAGGCAACTTCTTGTGAAC
ATTAAACGGTTTATCTCCTTCACCTCATATTAAAGTCCATACTCTTGGGATATATCTGACATCTCAATATTAAATGACTAAGATGACTAA
GTCGTTTATGTTGCTCCCACCTCACACAAAGTTAAAACTATTTGTTACTTTAAATAGTTTGACAATGTTATTTTAAAATCTGGACAAATC

>2007_2007_2_ADAM9-ADAM28_ADAM9_chr8_38871562_ENST00000487273_ADAM28_chr8_24168873_ENST00000265769_length(amino acids)=784AA_BP=111
MGSGARFPSGTLRVRWLLLLGLVGPVLGAARPGFQQTSHLSSYEIITPWRLTRERREAPRPYSKQVSYVIQAEGKEHIIHLERNKDLLPE
DFVVYTYNKEGTLITDHPNIQDDCYYQGHILNEKVSDASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGM
DGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKD
KIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDD
YSCKCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKI
KATFQCALGECCEKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGTEVADKSC
YNRNEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQGGSDNLPWKGRIVTFLTCKTFDPEDTSQEIGMVANGTKCGDNKVCINAECVDIE
KAYKSTNCSSKCKGHAVCDHELQCQCEEGWIPPDCDDSSVVFHFSIVVGVLFPMAVIFVVVAMVIRHQSSREKQKKDQRPLSTTGTRPHK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ADAM9-ADAM28

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ADAM9-ADAM28

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ADAM9-ADAM28

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ADAM9	C0015397	Disorder of eye	1	GENOMICS_ENGLAND
Hgene	ADAM9	C0033578	Prostatic Neoplasms	1	CTD_human
Hgene	ADAM9	C0376358	Malignant neoplasm of prostate	1	CTD_human
Hgene	ADAM9	C1423873	CONE-ROD DYSTROPHY 9	1	CTD_human;GENOMICS_ENGLAND
Hgene	ADAM9	C3489532	Cone-Rod Dystrophy 2	1	ORPHANET
Tgene		C0024121	Lung Neoplasms	1	CTD_human
Tgene		C0033578	Prostatic Neoplasms	1	CTD_human
Tgene		C0242379	Malignant neoplasm of lung	1	CTD_human
Tgene		C0376358	Malignant neoplasm of prostate	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:ADAM9-ADAM28 (FusionGDB2 ID:HG8754TG10863)

Fusion Gene Summary for ADAM9-ADAM28

Fusion Gene ORF analysis for ADAM9-ADAM28

Fusion Genomic Features for ADAM9-ADAM28

Fusion Protein Features for ADAM9-ADAM28

Fusion Gene Sequence for ADAM9-ADAM28

Fusion Gene PPI Analysis for ADAM9-ADAM28

Related Drugs for ADAM9-ADAM28

Related Diseases for ADAM9-ADAM28

Fusion Gene Studies
in Kim Lab