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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NRP1-PTEN (FusionGDB2 ID:HG8829TG5728)

Fusion Gene Summary for NRP1-PTEN

check button Fusion gene summary
Fusion gene informationFusion gene name: NRP1-PTEN
Fusion gene ID: hg8829tg5728
HgeneTgene
Gene symbol

NRP1

PTEN

Gene ID

8829

5728

Gene nameneuropilin 1phosphatase and tensin homolog
SynonymsBDCA4|CD304|NP1|NRP|VEGF165R10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|PTENbeta|TEP1
Cytomap('NRP1')('PTEN')

10p11.22

10q23.31

Type of geneprotein-codingprotein-coding
Descriptionneuropilin-1transmembrane receptorvascular endothelial cell growth factor 165 receptorphosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENMMAC1 phosphatase and tensin homolog deleted on chromosome 10PTENepsilonmitochondrial PTENalphamitochondrial phosphatase and tensin protein alphamutat
Modification date2020032220200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000265371, ENST00000374816, 
ENST00000374821, ENST00000374822, 
ENST00000374823, ENST00000374867, 
ENST00000395995, ENST00000432372, 
ENST00000374875, 		ENST00000265371, 
ENST00000374816, ENST00000374821, 
ENST00000374822, ENST00000374823, 
ENST00000374867, ENST00000374875, 
ENST00000395995, ENST00000432372, 
Fusion gene scores* DoF score13 X 9 X 6=70230 X 21 X 10=6300
# samples 1436
** MAII scorelog2(14/702*10)=-2.32604420335959
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(36/6300*10)=-4.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NRP1 [Title/Abstract] AND PTEN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNRP1(33619636)-PTEN(89717610), # samples:3
Anticipated loss of major functional domain due to fusion event.NRP1-PTEN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NRP1-PTEN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NRP1-PTEN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NRP1-PTEN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NRP1-PTEN seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
NRP1-PTEN seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
NRP1-PTEN seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
NRP1-PTEN seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
NRP1-PTEN seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNRP1

GO:0051894

positive regulation of focal adhesion assembly

24863063

TgenePTEN

GO:0001933

negative regulation of protein phosphorylation

20123964

TgenePTEN

GO:0006470

protein dephosphorylation

9256433

TgenePTEN

GO:0008285

negative regulation of cell proliferation

19057511

TgenePTEN

GO:0045736

negative regulation of cyclin-dependent protein serine/threonine kinase activity

21241890

TgenePTEN

GO:0046855

inositol phosphate dephosphorylation

9593664

TgenePTEN

GO:0046856

phosphatidylinositol dephosphorylation

9593664|9811831

TgenePTEN

GO:0050821

protein stabilization

20123964

TgenePTEN

GO:0060070

canonical Wnt signaling pathway

20123964

TgenePTEN

GO:1902807

negative regulation of cell cycle G1/S phase transition

10918569

TgenePTEN

GO:1904668

positive regulation of ubiquitin protein ligase activity

21241890

TgenePTEN

GO:2000060

positive regulation of ubiquitin-dependent protein catabolic process

21241890

TgenePTEN

GO:2000134

negative regulation of G1/S transition of mitotic cell cycle

21241890


check buttonFusion gene breakpoints across NRP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PTEN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-HC-A48F-01ANRP1chr10

33619636

-PTENchr10

89717610

+
ChimerDB4PRADTCGA-HC-A48FNRP1chr10

33619635

-PTENchr10

89717609

+
ChimerDB4PRADTCGA-HC-A48FNRP1chr10

33619636

-PTENchr10

89717610

+


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Fusion Gene ORF analysis for NRP1-PTEN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000265371ENST00000472832NRP1chr10

33619636

-PTENchr10

89717610

+
5CDS-3UTRENST00000265371ENST00000472832NRP1chr10

33619635

-PTENchr10

89717609

+
5CDS-3UTRENST00000374816ENST00000472832NRP1chr10

33619636

-PTENchr10

89717610

+
5CDS-3UTRENST00000374816ENST00000472832NRP1chr10

33619635

-PTENchr10

89717609

+
5CDS-3UTRENST00000374821ENST00000472832NRP1chr10

33619636

-PTENchr10

89717610

+
5CDS-3UTRENST00000374821ENST00000472832NRP1chr10

33619635

-PTENchr10

89717609

+
5CDS-3UTRENST00000374822ENST00000472832NRP1chr10

33619636

-PTENchr10

89717610

+
5CDS-3UTRENST00000374822ENST00000472832NRP1chr10

33619635

-PTENchr10

89717609

+
5CDS-3UTRENST00000374823ENST00000472832NRP1chr10

33619636

-PTENchr10

89717610

+
5CDS-3UTRENST00000374823ENST00000472832NRP1chr10

33619635

-PTENchr10

89717609

+
5CDS-3UTRENST00000374867ENST00000472832NRP1chr10

33619636

-PTENchr10

89717610

+
5CDS-3UTRENST00000374867ENST00000472832NRP1chr10

33619635

-PTENchr10

89717609

+
5CDS-3UTRENST00000395995ENST00000472832NRP1chr10

33619636

-PTENchr10

89717610

+
5CDS-3UTRENST00000395995ENST00000472832NRP1chr10

33619635

-PTENchr10

89717609

+
5CDS-3UTRENST00000432372ENST00000472832NRP1chr10

33619636

-PTENchr10

89717610

+
5CDS-3UTRENST00000432372ENST00000472832NRP1chr10

33619635

-PTENchr10

89717609

+
5UTR-3CDSENST00000374875ENST00000371953NRP1chr10

33619636

-PTENchr10

89717610

+
5UTR-3CDSENST00000374875ENST00000371953NRP1chr10

33619635

-PTENchr10

89717609

+
5UTR-3UTRENST00000374875ENST00000472832NRP1chr10

33619636

-PTENchr10

89717610

+
5UTR-3UTRENST00000374875ENST00000472832NRP1chr10

33619635

-PTENchr10

89717609

+
Frame-shiftENST00000374816ENST00000371953NRP1chr10

33619636

-PTENchr10

89717610

+
Frame-shiftENST00000374816ENST00000371953NRP1chr10

33619635

-PTENchr10

89717609

+
Frame-shiftENST00000374821ENST00000371953NRP1chr10

33619636

-PTENchr10

89717610

+
Frame-shiftENST00000374821ENST00000371953NRP1chr10

33619635

-PTENchr10

89717609

+
Frame-shiftENST00000374822ENST00000371953NRP1chr10

33619636

-PTENchr10

89717610

+
Frame-shiftENST00000374822ENST00000371953NRP1chr10

33619635

-PTENchr10

89717609

+
Frame-shiftENST00000374823ENST00000371953NRP1chr10

33619636

-PTENchr10

89717610

+
Frame-shiftENST00000374823ENST00000371953NRP1chr10

33619635

-PTENchr10

89717609

+
Frame-shiftENST00000374867ENST00000371953NRP1chr10

33619636

-PTENchr10

89717610

+
Frame-shiftENST00000374867ENST00000371953NRP1chr10

33619635

-PTENchr10

89717609

+
Frame-shiftENST00000395995ENST00000371953NRP1chr10

33619636

-PTENchr10

89717610

+
Frame-shiftENST00000395995ENST00000371953NRP1chr10

33619635

-PTENchr10

89717609

+
Frame-shiftENST00000432372ENST00000371953NRP1chr10

33619636

-PTENchr10

89717610

+
Frame-shiftENST00000432372ENST00000371953NRP1chr10

33619635

-PTENchr10

89717609

+
In-frameENST00000265371ENST00000371953NRP1chr10

33619636

-PTENchr10

89717610

+
In-frameENST00000265371ENST00000371953NRP1chr10

33619635

-PTENchr10

89717609

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265371NRP1chr1033619636-ENST00000371953PTENchr1089717610+78107748541351165
ENST00000265371NRP1chr1033619635-ENST00000371953PTENchr1089717609+78107748541351165

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265371ENST00000371953NRP1chr1033619636-PTENchr1089717610+0.0007062480.9992937
ENST00000265371ENST00000371953NRP1chr1033619635-PTENchr1089717609+0.0007062480.9992937

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Fusion Genomic Features for NRP1-PTEN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NRP1chr1033619635-PTENchr1089717609+2.84E-050.9999716
NRP1chr1033619635-PTENchr1089717609+2.84E-050.9999716
NRP1chr1033619635-PTENchr1089717609+2.84E-050.9999716
NRP1chr1033619635-PTENchr1089717609+2.84E-050.9999716

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NRP1-PTEN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:33619636/chr10:89717610)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePTENchr10:33619635chr10:89717609ENST0000037195359401_403211404.0RegionNote=PDZ domain-binding
TgenePTENchr10:33619636chr10:89717610ENST0000037195359401_403211404.0RegionNote=PDZ domain-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNRP1chr10:33619635chr10:89717609ENST00000265371-318147_26582924.0DomainCUB 2
HgeneNRP1chr10:33619635chr10:89717609ENST00000265371-31827_14182924.0DomainCUB 1
HgeneNRP1chr10:33619635chr10:89717609ENST00000265371-318645_81182924.0DomainMAM
HgeneNRP1chr10:33619635chr10:89717609ENST00000374821-211147_26582610.0DomainCUB 2
HgeneNRP1chr10:33619635chr10:89717609ENST00000374821-21127_14182610.0DomainCUB 1
HgeneNRP1chr10:33619635chr10:89717609ENST00000374821-211645_81182610.0DomainMAM
HgeneNRP1chr10:33619635chr10:89717609ENST00000374822-212147_26582645.0DomainCUB 2
HgeneNRP1chr10:33619635chr10:89717609ENST00000374822-21227_14182645.0DomainCUB 1
HgeneNRP1chr10:33619635chr10:89717609ENST00000374822-212645_81182645.0DomainMAM
HgeneNRP1chr10:33619635chr10:89717609ENST00000374867-217147_26582924.0DomainCUB 2
HgeneNRP1chr10:33619635chr10:89717609ENST00000374867-21727_14182924.0DomainCUB 1
HgeneNRP1chr10:33619635chr10:89717609ENST00000374867-217645_81182924.0DomainMAM
HgeneNRP1chr10:33619636chr10:89717610ENST00000265371-318147_26582924.0DomainCUB 2
HgeneNRP1chr10:33619636chr10:89717610ENST00000265371-31827_14182924.0DomainCUB 1
HgeneNRP1chr10:33619636chr10:89717610ENST00000265371-318645_81182924.0DomainMAM
HgeneNRP1chr10:33619636chr10:89717610ENST00000374821-211147_26582610.0DomainCUB 2
HgeneNRP1chr10:33619636chr10:89717610ENST00000374821-21127_14182610.0DomainCUB 1
HgeneNRP1chr10:33619636chr10:89717610ENST00000374821-211645_81182610.0DomainMAM
HgeneNRP1chr10:33619636chr10:89717610ENST00000374822-212147_26582645.0DomainCUB 2
HgeneNRP1chr10:33619636chr10:89717610ENST00000374822-21227_14182645.0DomainCUB 1
HgeneNRP1chr10:33619636chr10:89717610ENST00000374822-212645_81182645.0DomainMAM
HgeneNRP1chr10:33619636chr10:89717610ENST00000374867-217147_26582924.0DomainCUB 2
HgeneNRP1chr10:33619636chr10:89717610ENST00000374867-21727_14182924.0DomainCUB 1
HgeneNRP1chr10:33619636chr10:89717610ENST00000374867-217645_81182924.0DomainMAM
HgeneNRP1chr10:33619635chr10:89717609ENST00000265371-31822_85682924.0Topological domainExtracellular
HgeneNRP1chr10:33619635chr10:89717609ENST00000265371-318880_92382924.0Topological domainCytoplasmic
HgeneNRP1chr10:33619635chr10:89717609ENST00000374821-21122_85682610.0Topological domainExtracellular
HgeneNRP1chr10:33619635chr10:89717609ENST00000374821-211880_92382610.0Topological domainCytoplasmic
HgeneNRP1chr10:33619635chr10:89717609ENST00000374822-21222_85682645.0Topological domainExtracellular
HgeneNRP1chr10:33619635chr10:89717609ENST00000374822-212880_92382645.0Topological domainCytoplasmic
HgeneNRP1chr10:33619635chr10:89717609ENST00000374867-21722_85682924.0Topological domainExtracellular
HgeneNRP1chr10:33619635chr10:89717609ENST00000374867-217880_92382924.0Topological domainCytoplasmic
HgeneNRP1chr10:33619636chr10:89717610ENST00000265371-31822_85682924.0Topological domainExtracellular
HgeneNRP1chr10:33619636chr10:89717610ENST00000265371-318880_92382924.0Topological domainCytoplasmic
HgeneNRP1chr10:33619636chr10:89717610ENST00000374821-21122_85682610.0Topological domainExtracellular
HgeneNRP1chr10:33619636chr10:89717610ENST00000374821-211880_92382610.0Topological domainCytoplasmic
HgeneNRP1chr10:33619636chr10:89717610ENST00000374822-21222_85682645.0Topological domainExtracellular
HgeneNRP1chr10:33619636chr10:89717610ENST00000374822-212880_92382645.0Topological domainCytoplasmic
HgeneNRP1chr10:33619636chr10:89717610ENST00000374867-21722_85682924.0Topological domainExtracellular
HgeneNRP1chr10:33619636chr10:89717610ENST00000374867-217880_92382924.0Topological domainCytoplasmic
HgeneNRP1chr10:33619635chr10:89717609ENST00000265371-318857_87982924.0TransmembraneHelical
HgeneNRP1chr10:33619635chr10:89717609ENST00000374821-211857_87982610.0TransmembraneHelical
HgeneNRP1chr10:33619635chr10:89717609ENST00000374822-212857_87982645.0TransmembraneHelical
HgeneNRP1chr10:33619635chr10:89717609ENST00000374867-217857_87982924.0TransmembraneHelical
HgeneNRP1chr10:33619636chr10:89717610ENST00000265371-318857_87982924.0TransmembraneHelical
HgeneNRP1chr10:33619636chr10:89717610ENST00000374821-211857_87982610.0TransmembraneHelical
HgeneNRP1chr10:33619636chr10:89717610ENST00000374822-212857_87982645.0TransmembraneHelical
HgeneNRP1chr10:33619636chr10:89717610ENST00000374867-217857_87982924.0TransmembraneHelical
TgenePTENchr10:33619635chr10:89717609ENST000003719535914_185211404.0DomainPhosphatase tensin-type
TgenePTENchr10:33619635chr10:89717609ENST0000037195359190_350211404.0DomainC2 tensin-type
TgenePTENchr10:33619636chr10:89717610ENST000003719535914_185211404.0DomainPhosphatase tensin-type
TgenePTENchr10:33619636chr10:89717610ENST0000037195359190_350211404.0DomainC2 tensin-type


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Fusion Gene Sequence for NRP1-PTEN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>60345_60345_1_NRP1-PTEN_NRP1_chr10_33619635_ENST00000265371_PTEN_chr10_89717609_ENST00000371953_length(transcript)=7810nt_BP=774nt
GCCAAAACCTTTGACCAGAGTCTCCTTGCCAGCATTCCTACCTCCCTTTGGCCAGCTATTTGTGCCAGACACCCGGACCTCCCCTGGGCG
CCAGCTCCGCGGCTCCAACGGGTCCAGAAACAAGCCGGATTTTTTTTTTTTCTTCCTGGAAATTGGCTTTGGTGTGTGTTGCCCTACCTC
CCTCCTCCCCCTCCCACCCACAGCCCCCCCCCGGCCTTTTTTTTTTTTTTTTTTTTTTTTGAGACATGGCCCGGGCAGTGGCTCCTGGAA
GAGGAACAAGTGTGGGAAAAGGGAGAGGAAGCCGGAGCTAAATGACAGGATGCAGGCGACTTGAGACACAAAAAGAGAAGCGTTCCTCTC
GGATCCAGGCATTGCCTCGCTGCTTTCTTTTCTCCAAGACGGGCTGAGGATTGTACAGCTCTAGGCGGAGTTGGGGCTCTTCGGATCGCT
TAGATTCTCCTCTTTGCTGCATTTCCCCCCACGTCCTCGTTCTCCCGCGTCTGCCTGCGGACCCGGAGAAGGGAGAATGGAGAGGGGGCT
GCCGCTCCTCTGCGCCGTGCTCGCCCTCGTCCTCGCCCCGGCCGGCGCTTTTCGCAACGATAAATGTGGCGATACTATAAAAATTGAAAG
CCCCGGGTACCTTACATCTCCTGGTTATCCTCATTCTTATCACCCAAGTGAAAAATGCGAATGGCTGATTCAGGCTCCGGACCCATACCA
GAGAATTATGATCAACTTCAACCCTCACTTCGATTTGGAGGACAGAGACTGCAAATCCTCAGTTTGTGGTCTGCCAGCTAAAGGTGAAGA
TATATTCCTCCAATTCAGGACCCACACGACGGGAAGACAAGTTCATGTACTTTGAGTTCCCTCAGCCGTTACCTGTGTGTGGTGATATCA
AAGTAGAGTTCTTCCACAAACAGAACAAGATGCTAAAAAAGGACAAAATGTTTCACTTTTGGGTAAATACATTCTTCATACCAGGACCAG
AGGAAACCTCAGAAAAAGTAGAAAATGGAAGTCTATGTGATCAAGAAATCGATAGCATTTGCAGTATAGAGCGTGCAGATAATGACAAGG
AATATCTAGTACTTACTTTAACAAAAAATGATCTTGACAAAGCAAATAAAGACAAAGCCAACCGATACTTTTCTCCAAATTTTAAGGTGA
AGCTGTACTTCACAAAAACAGTAGAGGAGCCGTCAAATCCAGAGGCTAGCAGTTCAACTTCTGTAACACCAGATGTTAGTGACAATGAAC
CTGATCATTATAGATATTCTGACACCACTGACTCTGATCCAGAGAATGAACCTTTTGATGAAGATCAGCATACACAAATTACAAAAGTCT
GAATTTTTTTTTATCAAGAGGGATAAAACACCATGAAAATAAACTTGAATAAACTGAAAATGGACCTTTTTTTTTTTAATGGCAATAGGA
CATTGTGTCAGATTACCAGTTATAGGAACAATTCTCTTTTCCTGACCAATCTTGTTTTACCCTATACATCCACAGGGTTTTGACACTTGT
TGTCCAGTTGAAAAAAGGTTGTGTAGCTGTGTCATGTATATACCTTTTTGTGTCAAAAGGACATTTAAAATTCAATTAGGATTAATAAAG
ATGGCACTTTCCCGTTTTATTCCAGTTTTATAAAAAGTGGAGACAGACTGATGTGTATACGTAGGAATTTTTTCCTTTTGTGTTCTGTCA
CCAACTGAAGTGGCTAAAGAGCTTTGTGATATACTGGTTCACATCCTACCCCTTTGCACTTGTGGCAACAGATAAGTTTGCAGTTGGCTA
AGAGAGGTTTCCGAAGGGTTTTGCTACATTCTAATGCATGTATTCGGGTTAGGGGAATGGAGGGAATGCTCAGAAAGGAAATAATTTTAT
GCTGGACTCTGGACCATATACCATCTCCAGCTATTTACACACACCTTTCTTTAGCATGCTACAGTTATTAATCTGGACATTCGAGGAATT
GGCCGCTGTCACTGCTTGTTGTTTGCGCATTTTTTTTTAAAGCATATTGGTGCTAGAAAAGGCAGCTAAAGGAAGTGAATCTGTATTGGG
GTACAGGAATGAACCTTCTGCAACATCTTAAGATCCACAAATGAAGGGATATAAAAATAATGTCATAGGTAAGAAACACAGCAACAATGA
CTTAACCATATAAATGTGGAGGCTATCAACAAAGAATGGGCTTGAAACATTATAAAAATTGACAATGATTTATTAAATATGTTTTCTCAA
TTGTAACGACTTCTCCATCTCCTGTGTAATCAAGGCCAGTGCTAAAATTCAGATGCTGTTAGTACCTACATCAGTCAACAACTTACACTT
ATTTTACTAGTTTTCAATCATAATACCTGCTGTGGATGCTTCATGTGCTGCCTGCAAGCTTCTTTTTTCTCATTAAATATAAAATATTTT
GTAATGCTGCACAGAAATTTTCAATTTGAGATTCTACAGTAAGCGTTTTTTTTCTTTGAAGATTTATGATGCACTTATTCAATAGCTGTC
AGCCGTTCCACCCTTTTGACCTTACACATTCTATTACAATGAATTTTGCAGTTTTGCACATTTTTTAAATGTCATTAACTGTTAGGGAAT
TTTACTTGAATACTGAATACATATAATGTTTATATTAAAAAGGACATTTGTGTTAAAAAGGAAATTAGAGTTGCAGTAAACTTTCAATGC
TGCACACAAAAAAAAGACATTTGATTTTTCAGTAGAAATTGTCCTACATGTGCTTTATTGATTTGCTATTGAAAGAATAGGGTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTAAATGTGCAGTGTTGAATCATTTCTTCATAGTGCTCCCCCGAGTTGGGACTAGGGCTTCAATTTCACTT
CTTAAAAAAAATCATCATATATTTGATATGCCCAGACTGCATACGATTTTAAGCGGAGTACAACTACTATTGTAAAGCTAATGTGAAGAT
ATTATTAAAAAGGTTTTTTTTTCCAGAAATTTGGTGTCTTCAAATTATACCTTCACCTTGACATTTGAATATCCAGCCATTTTGTTTCTT
AATGGTATAAAATTCCATTTTCAATAACTTATTGGTGCTGAAATTGTTCACTAGCTGTGGTCTGACCTAGTTAATTTACAAATACAGATT
GAATAGGACCTACTAGAGCAGCATTTATAGAGTTTGATGGCAAATAGATTAGGCAGAACTTCATCTAAAATATTCTTAGTAAATAATGTT
GACACGTTTTCCATACCTTGTCAGTTTCATTCAACAATTTTTAAATTTTTAACAAAGCTCTTAGGATTTACACATTTATATTTAAACATT
GATATATAGAGTATTGATTGATTGCTCATAAGTTAAATTGGTAAAGTTAGAGACAACTATTCTAACACCTCACCATTGAAATTTATATGC
CACCTTGTCTTTCATAAAAGCTGAAAATTGTTACCTAAAATGAAAATCAACTTCATGTTTTGAAGATAGTTATAAATATTGTTCTTTGTT
ACAATTTCGGGCACCGCATATTAAAACGTAACTTTATTGTTCCAATATGTAACATGGAGGGCCAGGTCATAAATAATGACATTATAATGG
GCTTTTGCACTGTTATTATTTTTCCTTTGGAATGTGAAGGTCTGAATGAGGGTTTTGATTTTGAATGTTTCAATGTTTTTGAGAAGCCTT
GCTTACATTTTATGGTGTAGTCATTGGAAATGGAAAAATGGCATTATATATATTATATATATAAATATATATTATACATACTCTCCTTAC
TTTATTTCAGTTACCATCCCCATAGAATTTGACAAGAATTGCTATGACTGAAAGGTTTTCGAGTCCTAATTAAAACTTTATTTATGGCAG
TATTCATAATTAGCCTGAAATGCATTCTGTAGGTAATCTCTGAGTTTCTGGAATATTTTCTTAGACTTTTTGGATGTGCAGCAGCTTACA
TGTCTGAAGTTACTTGAAGGCATCACTTTTAAGAAAGCTTACAGTTGGGCCCTGTACCATCCCAAGTCCTTTGTAGCTCCTCTTGAACAT
GTTTGCCATACTTTTAAAAGGGTAGTTGAATAAATAGCATCACCATTCTTTGCTGTGGCACAGGTTATAAACTTAAGTGGAGTTTACCGG
CAGCATCAAATGTTTCAGCTTTAAAAAATAAAAGTAGGGTACAAGTTTAATGTTTAGTTCTAGAAATTTTGTGCAATATGTTCATAACGA
TGGCTGTGGTTGCCACAAAGTGCCTCGTTTACCTTTAAATACTGTTAATGTGTCATGCATGCAGATGGAAGGGGTGGAACTGTGCACTAA
AGTGGGGGCTTTAACTGTAGTATTTGGCAGAGTTGCCTTCTACCTGCCAGTTCAAAAGTTCAACCTGTTTTCATATAGAATATATATACT
AAAAAATTTCAGTCTGTTAAACAGCCTTACTCTGATTCAGCCTCTTCAGATACTCTTGTGCTGTGCAGCAGTGGCTCTGTGTGTAAATGC
TATGCACTGAGGATACACAAAAATACCAATATGATGTGTACAGGATAATGCCTCATCCCAATCAGATGTCCATTTGTTATTGTGTTTGTT
AACAACCCTTTATCTCTTAGTGTTATAAACTCCACTTAAAACTGATTAAAGTCTCATTCTTGTCATTGTGTGGGTGTTTTATTAAATGAG
AGTTTATAATTCAAATTGCTTAAGTCCATTGAAGTTTTAATTAATGGGCAGCCAAATGTGAATACAAAGTTTTCAGTTTTTTTTTTTCCT
GCTGTCCTTCAAAGCCTACTGTTTAAAAAAAAAAAAAAAAAAAAACATGGCCTGAGAGTAGAGTATCTGTCTACTCATGTTTAATTAAGG
AAAAACACTTATTTTTAGGGCTTTAGTCATCACTTCATAAATTGTATAAGCACATTAAATAGCGTTCTAGTCCTGAAAAAGTCCAAGATT
CTTAGAAAATTGTGCATATTTTTATTATGACAGATGTTTGAAGATAATTCCCCAGAATGGATTTGATACTTTAGATTTCAATTTTGTGGC
TTTTGTCTATTATTCTGTACTCTGCCATCAGCATATGGAAAGCTTCATTTACTCATCATGACTTGTGCCATATAAAAATTGATATTTCGG
AATAGTCTAAAGGACTTTTTGTACTTGAATTTAATCATGTTGTTTCTAATATTCTTAAAAGCTTGAAGACTAAAGCATATCCTTTCAACA
AAGCATAGTAAGGTAATAAGAAAGTGTAGTTTGTACAAGTGTTAAAAAAATAAAGTAGACAATGTTACAGTGGGACTTATTATTTCAAGT
TTACATTTTCTCCATGTAATTTTTTAAAAAGTAAATGAAAAAATGTGCAATAATGTAAAATATGAAGTGTATGTGTACACACATTTTATT
TTTCGGTATCTTGGGTATACGTATGGTTGAAAACTATACTGGAGTCTAAAAGTATTCTAATTTATAAGAAGACATTTTGGTGATGTTTGA
AAAATAGAAATGTGCTAGTTTTGTTTTTATATCATGTCCTTTGTACGTTGTAATATGAGCTGGCTTGGTTCAGTAAATGCCATCACCATT
TCCATTGAGAATTTAAAACTCACCAGTGTTTAATATGCAGGCTTCCAAAGGCTTATGAAAAAAATCAAGACCCTTAAATCTAGTTAATTT
GCTGCTAACATGAAACTCTTTGGTTCTTTTATTTTTGCCAGATAATTAGACACACATCTAAAGCTTAGTCTTAAATGGCTTAAGTGTAGC
TATTGATTAGTGCTGTTGCTAGTTCAGAAAGAAATGTTTGTGAATGGAAACAAGAATATTCAGTCCAAACTGTTGTAAGGACAGTACCTG
AAAACCAGGAAACAGGATAATGGAAAAAGTCTTTTAAAGATGAAATGTTGGAGCCAACTTTCTTATAGAATTAATTGTATGTGGCTATAG
AAAGCCTAATGATTGTTGCTTATTTTTGAGAGCATATTATTCTTTTATGACCATAATCTTGCTGTTTTTCCATCTTCCAAAAGATCTTCC
TTCTAATATGTATATCAGAATGTGGGTAGCCAGTCAGACAAATTCATATTGGTTGGTAGCTTTAAAAAGTTTGTAATGTGAAGACAGGAA
AGGACAAAATAGTTTGCTTTGGTGGTAGTACTCTGGTTGTTAAGCTAGGTATTTTGAGACTACTTCCCCATCACAACAACAATAAAATAA
TCACTCATAATCCTATCACCTGGAGACATAGCCATCGTTAATATGTTAGTGACTATACAATCATGTTTTCTTCTGTATATCCATGTATAT
TCTTTAAAAATGAAATTTATACTGTACCTGATCTCAAAGCTTTTTAGCTTAGTATATCTGTCATGAATTTGTAGGATGTTCCATTGCATC
AGAAAACGGACAGTGATTTGATTACTTTCTAATGCCACAGATGCAGATTACATGTAGTTATTGAGAATCCTTTCGAATTCAGTGGCTTAA
TCATGAATGTCTAAATATTGTTGACATTAGGATGATACATGTAAATTAAAGTTACATTTGTTTAGCATAGACAAGCTTAACATTGTAGAT
GTTTCTCTTCAAAAATCATCTTAAACATTTGCATTTGGAATTGTGTTAAATAGAATGTGTGAAACACTGTATTAGTAAACTTCATCACCT
TTCTACTTCCTTATAGTTTGAACTTTTCAGTTTTTGTAGTTCCCAAACAGTTGCTCAATTTAGAGCAAATTAATTTAACACCTGCCAAAA
AAAGGCTGCTGTTGGCTTATCAGTTGTCTTTAAATTCAAATGCTCATGTGACTTTTATCACATCAAAAAATATTTCATTAATGATTCACC
TTTAGCTCTGAAAATTACCGCGTTTAGTAATTATAGTGGGCTTATAAAAACATGCAACTCTTTTTGATAGTTATTTGAGAATTTTGGTGA
AAAATATTTAGCTGAGGGCAGTATAGAACTTATAAACCAATATATTGATATTTTTAAAACATTTTTACATATAAGTAAACTGCCATCTTT
GAGCATAACTACATTTAAAAATAAAGCTGCATATTTTTAAATCAAGTGTTTAACAAGAATTTATATTTTTTATTTTTTAAAATTAAAAAT
AATTTATATTTCCTCTGTTGCATGAGGATTCTCATCTGTGCTTATAATGGTTAGAGATTTTATTTGTGTGGAATGAAGTGAGGCTTGTAG
TCATGGTTCTAGTGTTTCAGTTTGCCAAGTCTGTTTACTGCAGTGAAATTCATCAAATGTTTCAGTGTGGTTTTCTGTAGCCTATCATTT
ACTGGCTATTTTTTTATGTACACCTTTAGGATTTTCTGCCTACTCTATCCAGTTGTCCAAATGATATCCTACATTTTACAAATGCCCTTT
CAGTTTCTATTTTCTTTTTCCATTAAATTGCCCTCATGTCCTAATGTGCAGTTTGTAAGTGTGTGTGTGTGTGTCTGTGTGTGTGTGAAT
TTGATTTTCAAGAGTGCTAGACTTCCAATTTGAGAGATTAAATAATTTAATTCAGGCAAACATTTTTCATTGGAATTTCACAGTTCATTG
TAATGAAAATGTTAATCCTGGATGACCTTTGACATACAGTAATGAATCTTGGATATTAATGAATTTGTTAGTAGCATCTTGATGTGTGTT
TTAATGAGTTATTTTCAAAGTTGTGCATTAAACCAAAGTTGGCATACTGGAAGTGTTTATATCAAGTTCCATTTGGCTACTGATGGACAA

>60345_60345_1_NRP1-PTEN_NRP1_chr10_33619635_ENST00000265371_PTEN_chr10_89717609_ENST00000371953_length(amino acids)=165AA_BP=
MYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKA

--------------------------------------------------------------
>60345_60345_2_NRP1-PTEN_NRP1_chr10_33619636_ENST00000265371_PTEN_chr10_89717610_ENST00000371953_length(transcript)=7810nt_BP=774nt
GCCAAAACCTTTGACCAGAGTCTCCTTGCCAGCATTCCTACCTCCCTTTGGCCAGCTATTTGTGCCAGACACCCGGACCTCCCCTGGGCG
CCAGCTCCGCGGCTCCAACGGGTCCAGAAACAAGCCGGATTTTTTTTTTTTCTTCCTGGAAATTGGCTTTGGTGTGTGTTGCCCTACCTC
CCTCCTCCCCCTCCCACCCACAGCCCCCCCCCGGCCTTTTTTTTTTTTTTTTTTTTTTTTGAGACATGGCCCGGGCAGTGGCTCCTGGAA
GAGGAACAAGTGTGGGAAAAGGGAGAGGAAGCCGGAGCTAAATGACAGGATGCAGGCGACTTGAGACACAAAAAGAGAAGCGTTCCTCTC
GGATCCAGGCATTGCCTCGCTGCTTTCTTTTCTCCAAGACGGGCTGAGGATTGTACAGCTCTAGGCGGAGTTGGGGCTCTTCGGATCGCT
TAGATTCTCCTCTTTGCTGCATTTCCCCCCACGTCCTCGTTCTCCCGCGTCTGCCTGCGGACCCGGAGAAGGGAGAATGGAGAGGGGGCT
GCCGCTCCTCTGCGCCGTGCTCGCCCTCGTCCTCGCCCCGGCCGGCGCTTTTCGCAACGATAAATGTGGCGATACTATAAAAATTGAAAG
CCCCGGGTACCTTACATCTCCTGGTTATCCTCATTCTTATCACCCAAGTGAAAAATGCGAATGGCTGATTCAGGCTCCGGACCCATACCA
GAGAATTATGATCAACTTCAACCCTCACTTCGATTTGGAGGACAGAGACTGCAAATCCTCAGTTTGTGGTCTGCCAGCTAAAGGTGAAGA
TATATTCCTCCAATTCAGGACCCACACGACGGGAAGACAAGTTCATGTACTTTGAGTTCCCTCAGCCGTTACCTGTGTGTGGTGATATCA
AAGTAGAGTTCTTCCACAAACAGAACAAGATGCTAAAAAAGGACAAAATGTTTCACTTTTGGGTAAATACATTCTTCATACCAGGACCAG
AGGAAACCTCAGAAAAAGTAGAAAATGGAAGTCTATGTGATCAAGAAATCGATAGCATTTGCAGTATAGAGCGTGCAGATAATGACAAGG
AATATCTAGTACTTACTTTAACAAAAAATGATCTTGACAAAGCAAATAAAGACAAAGCCAACCGATACTTTTCTCCAAATTTTAAGGTGA
AGCTGTACTTCACAAAAACAGTAGAGGAGCCGTCAAATCCAGAGGCTAGCAGTTCAACTTCTGTAACACCAGATGTTAGTGACAATGAAC
CTGATCATTATAGATATTCTGACACCACTGACTCTGATCCAGAGAATGAACCTTTTGATGAAGATCAGCATACACAAATTACAAAAGTCT
GAATTTTTTTTTATCAAGAGGGATAAAACACCATGAAAATAAACTTGAATAAACTGAAAATGGACCTTTTTTTTTTTAATGGCAATAGGA
CATTGTGTCAGATTACCAGTTATAGGAACAATTCTCTTTTCCTGACCAATCTTGTTTTACCCTATACATCCACAGGGTTTTGACACTTGT
TGTCCAGTTGAAAAAAGGTTGTGTAGCTGTGTCATGTATATACCTTTTTGTGTCAAAAGGACATTTAAAATTCAATTAGGATTAATAAAG
ATGGCACTTTCCCGTTTTATTCCAGTTTTATAAAAAGTGGAGACAGACTGATGTGTATACGTAGGAATTTTTTCCTTTTGTGTTCTGTCA
CCAACTGAAGTGGCTAAAGAGCTTTGTGATATACTGGTTCACATCCTACCCCTTTGCACTTGTGGCAACAGATAAGTTTGCAGTTGGCTA
AGAGAGGTTTCCGAAGGGTTTTGCTACATTCTAATGCATGTATTCGGGTTAGGGGAATGGAGGGAATGCTCAGAAAGGAAATAATTTTAT
GCTGGACTCTGGACCATATACCATCTCCAGCTATTTACACACACCTTTCTTTAGCATGCTACAGTTATTAATCTGGACATTCGAGGAATT
GGCCGCTGTCACTGCTTGTTGTTTGCGCATTTTTTTTTAAAGCATATTGGTGCTAGAAAAGGCAGCTAAAGGAAGTGAATCTGTATTGGG
GTACAGGAATGAACCTTCTGCAACATCTTAAGATCCACAAATGAAGGGATATAAAAATAATGTCATAGGTAAGAAACACAGCAACAATGA
CTTAACCATATAAATGTGGAGGCTATCAACAAAGAATGGGCTTGAAACATTATAAAAATTGACAATGATTTATTAAATATGTTTTCTCAA
TTGTAACGACTTCTCCATCTCCTGTGTAATCAAGGCCAGTGCTAAAATTCAGATGCTGTTAGTACCTACATCAGTCAACAACTTACACTT
ATTTTACTAGTTTTCAATCATAATACCTGCTGTGGATGCTTCATGTGCTGCCTGCAAGCTTCTTTTTTCTCATTAAATATAAAATATTTT
GTAATGCTGCACAGAAATTTTCAATTTGAGATTCTACAGTAAGCGTTTTTTTTCTTTGAAGATTTATGATGCACTTATTCAATAGCTGTC
AGCCGTTCCACCCTTTTGACCTTACACATTCTATTACAATGAATTTTGCAGTTTTGCACATTTTTTAAATGTCATTAACTGTTAGGGAAT
TTTACTTGAATACTGAATACATATAATGTTTATATTAAAAAGGACATTTGTGTTAAAAAGGAAATTAGAGTTGCAGTAAACTTTCAATGC
TGCACACAAAAAAAAGACATTTGATTTTTCAGTAGAAATTGTCCTACATGTGCTTTATTGATTTGCTATTGAAAGAATAGGGTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTAAATGTGCAGTGTTGAATCATTTCTTCATAGTGCTCCCCCGAGTTGGGACTAGGGCTTCAATTTCACTT
CTTAAAAAAAATCATCATATATTTGATATGCCCAGACTGCATACGATTTTAAGCGGAGTACAACTACTATTGTAAAGCTAATGTGAAGAT
ATTATTAAAAAGGTTTTTTTTTCCAGAAATTTGGTGTCTTCAAATTATACCTTCACCTTGACATTTGAATATCCAGCCATTTTGTTTCTT
AATGGTATAAAATTCCATTTTCAATAACTTATTGGTGCTGAAATTGTTCACTAGCTGTGGTCTGACCTAGTTAATTTACAAATACAGATT
GAATAGGACCTACTAGAGCAGCATTTATAGAGTTTGATGGCAAATAGATTAGGCAGAACTTCATCTAAAATATTCTTAGTAAATAATGTT
GACACGTTTTCCATACCTTGTCAGTTTCATTCAACAATTTTTAAATTTTTAACAAAGCTCTTAGGATTTACACATTTATATTTAAACATT
GATATATAGAGTATTGATTGATTGCTCATAAGTTAAATTGGTAAAGTTAGAGACAACTATTCTAACACCTCACCATTGAAATTTATATGC
CACCTTGTCTTTCATAAAAGCTGAAAATTGTTACCTAAAATGAAAATCAACTTCATGTTTTGAAGATAGTTATAAATATTGTTCTTTGTT
ACAATTTCGGGCACCGCATATTAAAACGTAACTTTATTGTTCCAATATGTAACATGGAGGGCCAGGTCATAAATAATGACATTATAATGG
GCTTTTGCACTGTTATTATTTTTCCTTTGGAATGTGAAGGTCTGAATGAGGGTTTTGATTTTGAATGTTTCAATGTTTTTGAGAAGCCTT
GCTTACATTTTATGGTGTAGTCATTGGAAATGGAAAAATGGCATTATATATATTATATATATAAATATATATTATACATACTCTCCTTAC
TTTATTTCAGTTACCATCCCCATAGAATTTGACAAGAATTGCTATGACTGAAAGGTTTTCGAGTCCTAATTAAAACTTTATTTATGGCAG
TATTCATAATTAGCCTGAAATGCATTCTGTAGGTAATCTCTGAGTTTCTGGAATATTTTCTTAGACTTTTTGGATGTGCAGCAGCTTACA
TGTCTGAAGTTACTTGAAGGCATCACTTTTAAGAAAGCTTACAGTTGGGCCCTGTACCATCCCAAGTCCTTTGTAGCTCCTCTTGAACAT
GTTTGCCATACTTTTAAAAGGGTAGTTGAATAAATAGCATCACCATTCTTTGCTGTGGCACAGGTTATAAACTTAAGTGGAGTTTACCGG
CAGCATCAAATGTTTCAGCTTTAAAAAATAAAAGTAGGGTACAAGTTTAATGTTTAGTTCTAGAAATTTTGTGCAATATGTTCATAACGA
TGGCTGTGGTTGCCACAAAGTGCCTCGTTTACCTTTAAATACTGTTAATGTGTCATGCATGCAGATGGAAGGGGTGGAACTGTGCACTAA
AGTGGGGGCTTTAACTGTAGTATTTGGCAGAGTTGCCTTCTACCTGCCAGTTCAAAAGTTCAACCTGTTTTCATATAGAATATATATACT
AAAAAATTTCAGTCTGTTAAACAGCCTTACTCTGATTCAGCCTCTTCAGATACTCTTGTGCTGTGCAGCAGTGGCTCTGTGTGTAAATGC
TATGCACTGAGGATACACAAAAATACCAATATGATGTGTACAGGATAATGCCTCATCCCAATCAGATGTCCATTTGTTATTGTGTTTGTT
AACAACCCTTTATCTCTTAGTGTTATAAACTCCACTTAAAACTGATTAAAGTCTCATTCTTGTCATTGTGTGGGTGTTTTATTAAATGAG
AGTTTATAATTCAAATTGCTTAAGTCCATTGAAGTTTTAATTAATGGGCAGCCAAATGTGAATACAAAGTTTTCAGTTTTTTTTTTTCCT
GCTGTCCTTCAAAGCCTACTGTTTAAAAAAAAAAAAAAAAAAAAACATGGCCTGAGAGTAGAGTATCTGTCTACTCATGTTTAATTAAGG
AAAAACACTTATTTTTAGGGCTTTAGTCATCACTTCATAAATTGTATAAGCACATTAAATAGCGTTCTAGTCCTGAAAAAGTCCAAGATT
CTTAGAAAATTGTGCATATTTTTATTATGACAGATGTTTGAAGATAATTCCCCAGAATGGATTTGATACTTTAGATTTCAATTTTGTGGC
TTTTGTCTATTATTCTGTACTCTGCCATCAGCATATGGAAAGCTTCATTTACTCATCATGACTTGTGCCATATAAAAATTGATATTTCGG
AATAGTCTAAAGGACTTTTTGTACTTGAATTTAATCATGTTGTTTCTAATATTCTTAAAAGCTTGAAGACTAAAGCATATCCTTTCAACA
AAGCATAGTAAGGTAATAAGAAAGTGTAGTTTGTACAAGTGTTAAAAAAATAAAGTAGACAATGTTACAGTGGGACTTATTATTTCAAGT
TTACATTTTCTCCATGTAATTTTTTAAAAAGTAAATGAAAAAATGTGCAATAATGTAAAATATGAAGTGTATGTGTACACACATTTTATT
TTTCGGTATCTTGGGTATACGTATGGTTGAAAACTATACTGGAGTCTAAAAGTATTCTAATTTATAAGAAGACATTTTGGTGATGTTTGA
AAAATAGAAATGTGCTAGTTTTGTTTTTATATCATGTCCTTTGTACGTTGTAATATGAGCTGGCTTGGTTCAGTAAATGCCATCACCATT
TCCATTGAGAATTTAAAACTCACCAGTGTTTAATATGCAGGCTTCCAAAGGCTTATGAAAAAAATCAAGACCCTTAAATCTAGTTAATTT
GCTGCTAACATGAAACTCTTTGGTTCTTTTATTTTTGCCAGATAATTAGACACACATCTAAAGCTTAGTCTTAAATGGCTTAAGTGTAGC
TATTGATTAGTGCTGTTGCTAGTTCAGAAAGAAATGTTTGTGAATGGAAACAAGAATATTCAGTCCAAACTGTTGTAAGGACAGTACCTG
AAAACCAGGAAACAGGATAATGGAAAAAGTCTTTTAAAGATGAAATGTTGGAGCCAACTTTCTTATAGAATTAATTGTATGTGGCTATAG
AAAGCCTAATGATTGTTGCTTATTTTTGAGAGCATATTATTCTTTTATGACCATAATCTTGCTGTTTTTCCATCTTCCAAAAGATCTTCC
TTCTAATATGTATATCAGAATGTGGGTAGCCAGTCAGACAAATTCATATTGGTTGGTAGCTTTAAAAAGTTTGTAATGTGAAGACAGGAA
AGGACAAAATAGTTTGCTTTGGTGGTAGTACTCTGGTTGTTAAGCTAGGTATTTTGAGACTACTTCCCCATCACAACAACAATAAAATAA
TCACTCATAATCCTATCACCTGGAGACATAGCCATCGTTAATATGTTAGTGACTATACAATCATGTTTTCTTCTGTATATCCATGTATAT
TCTTTAAAAATGAAATTTATACTGTACCTGATCTCAAAGCTTTTTAGCTTAGTATATCTGTCATGAATTTGTAGGATGTTCCATTGCATC
AGAAAACGGACAGTGATTTGATTACTTTCTAATGCCACAGATGCAGATTACATGTAGTTATTGAGAATCCTTTCGAATTCAGTGGCTTAA
TCATGAATGTCTAAATATTGTTGACATTAGGATGATACATGTAAATTAAAGTTACATTTGTTTAGCATAGACAAGCTTAACATTGTAGAT
GTTTCTCTTCAAAAATCATCTTAAACATTTGCATTTGGAATTGTGTTAAATAGAATGTGTGAAACACTGTATTAGTAAACTTCATCACCT
TTCTACTTCCTTATAGTTTGAACTTTTCAGTTTTTGTAGTTCCCAAACAGTTGCTCAATTTAGAGCAAATTAATTTAACACCTGCCAAAA
AAAGGCTGCTGTTGGCTTATCAGTTGTCTTTAAATTCAAATGCTCATGTGACTTTTATCACATCAAAAAATATTTCATTAATGATTCACC
TTTAGCTCTGAAAATTACCGCGTTTAGTAATTATAGTGGGCTTATAAAAACATGCAACTCTTTTTGATAGTTATTTGAGAATTTTGGTGA
AAAATATTTAGCTGAGGGCAGTATAGAACTTATAAACCAATATATTGATATTTTTAAAACATTTTTACATATAAGTAAACTGCCATCTTT
GAGCATAACTACATTTAAAAATAAAGCTGCATATTTTTAAATCAAGTGTTTAACAAGAATTTATATTTTTTATTTTTTAAAATTAAAAAT
AATTTATATTTCCTCTGTTGCATGAGGATTCTCATCTGTGCTTATAATGGTTAGAGATTTTATTTGTGTGGAATGAAGTGAGGCTTGTAG
TCATGGTTCTAGTGTTTCAGTTTGCCAAGTCTGTTTACTGCAGTGAAATTCATCAAATGTTTCAGTGTGGTTTTCTGTAGCCTATCATTT
ACTGGCTATTTTTTTATGTACACCTTTAGGATTTTCTGCCTACTCTATCCAGTTGTCCAAATGATATCCTACATTTTACAAATGCCCTTT
CAGTTTCTATTTTCTTTTTCCATTAAATTGCCCTCATGTCCTAATGTGCAGTTTGTAAGTGTGTGTGTGTGTGTCTGTGTGTGTGTGAAT
TTGATTTTCAAGAGTGCTAGACTTCCAATTTGAGAGATTAAATAATTTAATTCAGGCAAACATTTTTCATTGGAATTTCACAGTTCATTG
TAATGAAAATGTTAATCCTGGATGACCTTTGACATACAGTAATGAATCTTGGATATTAATGAATTTGTTAGTAGCATCTTGATGTGTGTT
TTAATGAGTTATTTTCAAAGTTGTGCATTAAACCAAAGTTGGCATACTGGAAGTGTTTATATCAAGTTCCATTTGGCTACTGATGGACAA

>60345_60345_2_NRP1-PTEN_NRP1_chr10_33619636_ENST00000265371_PTEN_chr10_89717610_ENST00000371953_length(amino acids)=165AA_BP=
MYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NRP1-PTEN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NRP1-PTEN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NRP1-PTEN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNRP1C0014175Endometriosis1CTD_human
HgeneNRP1C0023895Liver diseases1CTD_human
HgeneNRP1C0030297Pancreatic Neoplasm1CTD_human
HgeneNRP1C0033578Prostatic Neoplasms1CTD_human
HgeneNRP1C0086565Liver Dysfunction1CTD_human
HgeneNRP1C0269102Endometrioma1CTD_human
HgeneNRP1C0346647Malignant neoplasm of pancreas1CTD_human
HgeneNRP1C0376358Malignant neoplasm of prostate1CTD_human
TgeneC0018553Hamartoma Syndrome, Multiple36CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC1959582PTEN Hamartoma Tumor Syndrome23CLINGEN;CTD_human;GENOMICS_ENGLAND
TgeneC0376358Malignant neoplasm of prostate18CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0265326Bannayan-Riley-Ruvalcaba Syndrome16CTD_human;GENOMICS_ENGLAND
TgeneC0033578Prostatic Neoplasms15CTD_human
TgeneC0391826Lhermitte-Duclos disease15CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC0085261Proteus Syndrome6CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC0376634Craniofacial Abnormalities6CTD_human
TgeneC1854416MACROCEPHALY/AUTISM SYNDROME6CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0020796Profound Mental Retardation5CTD_human
TgeneC0025202melanoma5CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0025363Mental Retardation, Psychosocial5CTD_human
TgeneC0476089Endometrial Carcinoma5CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0917816Mental deficiency5CTD_human
TgeneC3714756Intellectual Disability5CTD_human
TgeneC0004352Autistic Disorder4CTD_human
TgeneC0006142Malignant neoplasm of breast4CGI;CTD_human;UNIPROT
TgeneC0014170Endometrial Neoplasms4CTD_human
TgeneC0678222Breast Carcinoma4CGI;CTD_human
TgeneC1257931Mammary Neoplasms, Human4CTD_human
TgeneC1458155Mammary Neoplasms4CTD_human
TgeneC1866398Proteus-Like Syndrome (disorder)4CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC4704874Mammary Carcinoma, Human4CTD_human
TgeneC0008073Developmental Disabilities3CTD_human
TgeneC0085996Child Development Deviations3CTD_human
TgeneC0085997Child Development Disorders, Specific3CTD_human
TgeneC0345893Juvenile polyposis syndrome3ORPHANET
TgeneC1168401Squamous cell carcinoma of the head and neck3CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC1848599VACTERL Association With Hydrocephalus3CTD_human;GENOMICS_ENGLAND
TgeneC0024121Lung Neoplasms2CGI;CTD_human
TgeneC0242379Malignant neoplasm of lung2CGI;CTD_human
TgeneC0282612Prostatic Intraepithelial Neoplasias2CTD_human
TgeneC2751642GLIOMA SUSCEPTIBILITY 22GENOMICS_ENGLAND;UNIPROT
TgeneC0000772Multiple congenital anomalies1CTD_human
TgeneC0001418Adenocarcinoma1CTD_human
TgeneC0003081Anisometropia1CTD_human
TgeneC0004096Asthma1CTD_human
TgeneC0004565Melanoma, B161CTD_human
TgeneC0007097Carcinoma1CTD_human
TgeneC0007134Renal Cell Carcinoma1CTD_human
TgeneC0007621Neoplastic Cell Transformation1CTD_human
TgeneC0009075Melanoma, Cloudman S911CTD_human
TgeneC0010606Adenoid Cystic Carcinoma1CTD_human
TgeneC0011757Developmental Coordination Disorder1CTD_human
TgeneC0014173Endometrial Hyperplasia1CTD_human
TgeneC0015695Fatty Liver1CTD_human
TgeneC0017638Glioma1CGI;CTD_human;UNIPROT
TgeneC0018598Melanoma, Harding-Passey1CTD_human
TgeneC0018916Hemangioma1CTD_human
TgeneC0020538Hypertensive disease1CTD_human
TgeneC0020564Hypertrophy1CTD_human
TgeneC0021655Insulin Resistance1CTD_human
TgeneC0023012Language Delay1CTD_human
TgeneC0023014Language Development Disorders1CTD_human
TgeneC0023418leukemia1CTD_human
TgeneC0023798Lipoma1CTD_human
TgeneC0023801Lipomatosis1CTD_human
TgeneC0023890Liver Cirrhosis1CTD_human
TgeneC0023976Long QT Syndrome1CTD_human
TgeneC0024299Lymphoma1CTD_human
TgeneC0025205Melanoma, Experimental1CTD_human
TgeneC0025286Meningioma1CTD_human
TgeneC0026613Motor Skills Disorders1CTD_human
TgeneC0027055Myocardial Reperfusion Injury1CTD_human
TgeneC0027626Neoplasm Invasiveness1CTD_human
TgeneC0027627Neoplasm Metastasis1CTD_human
TgeneC0030297Pancreatic Neoplasm1CTD_human
TgeneC0035126Reperfusion Injury1CTD_human
TgeneC0036920Sezary Syndrome1CTD_human
TgeneC0037116Silicosis1CTD_human
TgeneC0037274Dermatologic disorders1CTD_human
TgeneC0149925Small cell carcinoma of lung1CTD_human
TgeneC0152427Polydactyly1CTD_human
TgeneC0175704LEOPARD Syndrome1CTD_human
TgeneC0205641Adenocarcinoma, Basal Cell1CTD_human
TgeneC0205642Adenocarcinoma, Oxyphilic1CTD_human
TgeneC0205643Carcinoma, Cribriform1CTD_human
TgeneC0205644Carcinoma, Granular Cell1CTD_human
TgeneC0205645Adenocarcinoma, Tubular1CTD_human
TgeneC0205696Anaplastic carcinoma1CTD_human
TgeneC0205697Carcinoma, Spindle-Cell1CTD_human
TgeneC0205698Undifferentiated carcinoma1CTD_human
TgeneC0205699Carcinomatosis1CTD_human
TgeneC0205788Histiocytoid hemangioma1CTD_human
TgeneC0205789Hemangioma, Intramuscular1CTD_human
TgeneC0205822Hibernoma1CTD_human
TgeneC0205823Pleomorphic Lipoma1CTD_human
TgeneC0205834Meningiomas, Multiple1CTD_human
TgeneC0206669Hepatocellular Adenoma1CTD_human
TgeneC0206698Cholangiocarcinoma1CTD_human
TgeneC0235874Disease Exacerbation1CTD_human
TgeneC0239946Fibrosis, Liver1CTD_human
TgeneC0241210Speech Delay1CTD_human
TgeneC0259783mixed gliomas1CTD_human
TgeneC0259785Malignant Meningioma1CTD_human
TgeneC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
TgeneC0280302Squamous cell carcinoma of lip1ORPHANET
TgeneC0280313Squamous cell carcinoma of oropharynx1ORPHANET
TgeneC0280321Squamous cell carcinoma of the hypopharynx1ORPHANET
TgeneC0280324Laryngeal Squamous Cell Carcinoma1ORPHANET
TgeneC0281784Benign Meningioma1CTD_human
TgeneC0334605Meningothelial meningioma1CTD_human
TgeneC0334606Fibrous Meningioma1CTD_human
TgeneC0334607Psammomatous Meningioma1CTD_human
TgeneC0334608Angiomatous Meningioma1CTD_human
TgeneC0334609Hemangioblastic Meningioma1CTD_human
TgeneC0334610Hemangiopericytic Meningioma1CTD_human
TgeneC0334611Transitional Meningioma1CTD_human
TgeneC0345905Intrahepatic Cholangiocarcinoma1CTD_human
TgeneC0346647Malignant neoplasm of pancreas1CTD_human
TgeneC0347515Spinal Meningioma1CTD_human
TgeneC0349578Complex Endometrial Hyperplasia1CTD_human
TgeneC0349579Atypical Endometrial Hyperplasia1CTD_human
TgeneC0349604Intracranial Meningioma1CTD_human
TgeneC0400966Non-alcoholic Fatty Liver Disease1CTD_human
TgeneC0431121Clear Cell Meningioma1CTD_human
TgeneC0454655Semantic-Pragmatic Disorder1CTD_human
TgeneC0456483Simple Endometrial Hyperplasia1CTD_human
TgeneC0457190Xanthomatous Meningioma1CTD_human
TgeneC0555198Malignant Glioma1CTD_human
TgeneC0585362Squamous cell carcinoma of mouth1CGI;ORPHANET
TgeneC0677608Chorioangioma1CTD_human
TgeneC0677776Hereditary Breast and Ovarian Cancer Syndrome1ORPHANET
TgeneC0751257Auditory Processing Disorder, Central1CTD_human
TgeneC0751303Cerebral Convexity Meningioma1CTD_human
TgeneC0751304Parasagittal Meningioma1CTD_human
TgeneC0919267ovarian neoplasm1CGI;CTD_human
TgeneC0920563Insulin Sensitivity1CTD_human
TgeneC1140680Malignant neoplasm of ovary1CGI;CTD_human
TgeneC1176475Ductal Carcinoma1CTD_human
TgeneC1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneC1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneC1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneC1266181Dysplastic gangliocytoma of cerebellum (Lhermitte-Duclos)1ORPHANET
TgeneC1306837Papillary Renal Cell Carcinoma1CTD_human
TgeneC1334261Intraorbital Meningioma1CTD_human
TgeneC1334271Intraventricular Meningioma1CTD_human
TgeneC1335107Olfactory Groove Meningioma1CTD_human
TgeneC1384406Secretory meningioma1CTD_human
TgeneC1384408Microcystic meningioma1CTD_human
TgeneC1527197Angioblastic Meningioma1CTD_human
TgeneC1535926Neurodevelopmental Disorders1CTD_human
TgeneC1565950Posterior Fossa Meningioma1CTD_human
TgeneC1565951Sphenoid Wing Meningioma1CTD_human
TgeneC1835047MELANOMA, CUTANEOUS MALIGNANT, 11GENOMICS_ENGLAND
TgeneC1959588Angioma1CTD_human
TgeneC2239176Liver carcinoma1CTD_human
TgeneC2711227Steatohepatitis1CTD_human
TgeneC2931822Nasopharyngeal carcinoma1CTD_human
TgeneC3163622Papillary Meningioma1CTD_human
TgeneC3241937Nonalcoholic Steatohepatitis1CTD_human
TgeneC3489413Lipomatosis, Multiple1CTD_human
TgeneC3551915MENINGIOMA, FAMILIAL, SUSCEPTIBILITY TO1GENOMICS_ENGLAND
TgeneC3714976ACTIVATED PI3K-DELTA SYNDROME1ORPHANET
TgeneC3805278Extrahepatic Cholangiocarcinoma1CTD_human
TgeneC4225426THYROID CANCER, NONMEDULLARY, 21GENOMICS_ENGLAND
TgeneC4551484Leopard Syndrome 11CTD_human