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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ARHGEF7-RTTN (FusionGDB2 ID:HG8874TG25914) |
Fusion Gene Summary for ARHGEF7-RTTN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARHGEF7-RTTN | Fusion gene ID: hg8874tg25914 | Hgene | Tgene | Gene symbol | ARHGEF7 | RTTN | Gene ID | 8874 | 25914 |
| Gene name | Rho guanine nucleotide exchange factor 7 | rotatin | |
| Synonyms | BETA-PIX|COOL-1|COOL1|Nbla10314|P50|P50BP|P85|P85COOL1|P85SPR|PAK3|PIXB | MSSP | |
| Cytomap | ('ARHGEF7')('RTTN') 13q34 | 18q22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rho guanine nucleotide exchange factor 7PAK-interacting exchange factor betaRho guanine nucleotide exchange factor (GEF) 7SH3 domain-containing proline-rich protein | rotatin | |
| Modification date | 20200327 | 20200322 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000317133, ENST00000370623, ENST00000375741, ENST00000218789, ENST00000375736, ENST00000544132, ENST00000375723, ENST00000375737, ENST00000375739, ENST00000426073, ENST00000478679, ENST00000483189, | ||
| Fusion gene scores | * DoF score | 25 X 17 X 12=5100 | 8 X 7 X 5=280 |
| # samples | 26 | 8 | |
| ** MAII score | log2(26/5100*10)=-4.29391371871777 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ARHGEF7 [Title/Abstract] AND RTTN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ARHGEF7(111806338)-RTTN(67817969), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | ARHGEF7-RTTN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARHGEF7-RTTN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ARHGEF7 | GO:0043547 | positive regulation of GTPase activity | 21048939 |
| Fusion gene breakpoints across ARHGEF7 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across RTTN (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SARC | TCGA-KD-A5QS-01A | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
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Fusion Gene ORF analysis for ARHGEF7-RTTN |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000317133 | ENST00000579986 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| 5CDS-intron | ENST00000370623 | ENST00000579986 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| 5CDS-intron | ENST00000375741 | ENST00000579986 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| 5UTR-3CDS | ENST00000218789 | ENST00000255674 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| 5UTR-3CDS | ENST00000218789 | ENST00000437017 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| 5UTR-3CDS | ENST00000218789 | ENST00000454359 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| 5UTR-3CDS | ENST00000375736 | ENST00000255674 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| 5UTR-3CDS | ENST00000375736 | ENST00000437017 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| 5UTR-3CDS | ENST00000375736 | ENST00000454359 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| 5UTR-3CDS | ENST00000544132 | ENST00000255674 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| 5UTR-3CDS | ENST00000544132 | ENST00000437017 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| 5UTR-3CDS | ENST00000544132 | ENST00000454359 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| 5UTR-intron | ENST00000218789 | ENST00000579986 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| 5UTR-intron | ENST00000375736 | ENST00000579986 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| 5UTR-intron | ENST00000544132 | ENST00000579986 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| In-frame | ENST00000317133 | ENST00000255674 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| In-frame | ENST00000317133 | ENST00000437017 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| In-frame | ENST00000317133 | ENST00000454359 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| In-frame | ENST00000370623 | ENST00000255674 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| In-frame | ENST00000370623 | ENST00000437017 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| In-frame | ENST00000370623 | ENST00000454359 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| In-frame | ENST00000375741 | ENST00000255674 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| In-frame | ENST00000375741 | ENST00000437017 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| In-frame | ENST00000375741 | ENST00000454359 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| intron-3CDS | ENST00000375723 | ENST00000255674 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| intron-3CDS | ENST00000375723 | ENST00000437017 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| intron-3CDS | ENST00000375723 | ENST00000454359 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| intron-3CDS | ENST00000375737 | ENST00000255674 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| intron-3CDS | ENST00000375737 | ENST00000437017 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| intron-3CDS | ENST00000375737 | ENST00000454359 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| intron-3CDS | ENST00000375739 | ENST00000255674 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| intron-3CDS | ENST00000375739 | ENST00000437017 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| intron-3CDS | ENST00000375739 | ENST00000454359 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| intron-3CDS | ENST00000426073 | ENST00000255674 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| intron-3CDS | ENST00000426073 | ENST00000437017 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| intron-3CDS | ENST00000426073 | ENST00000454359 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| intron-3CDS | ENST00000478679 | ENST00000255674 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| intron-3CDS | ENST00000478679 | ENST00000437017 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| intron-3CDS | ENST00000478679 | ENST00000454359 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| intron-3CDS | ENST00000483189 | ENST00000255674 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| intron-3CDS | ENST00000483189 | ENST00000437017 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| intron-3CDS | ENST00000483189 | ENST00000454359 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| intron-intron | ENST00000375723 | ENST00000579986 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| intron-intron | ENST00000375737 | ENST00000579986 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| intron-intron | ENST00000375739 | ENST00000579986 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| intron-intron | ENST00000426073 | ENST00000579986 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| intron-intron | ENST00000478679 | ENST00000579986 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| intron-intron | ENST00000483189 | ENST00000579986 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000317133 | ARHGEF7 | chr13 | 111806338 | + | ENST00000255674 | RTTN | chr18 | 67817969 | - | 6270 | 1160 | 710 | 5911 | 1733 |
| ENST00000317133 | ARHGEF7 | chr13 | 111806338 | + | ENST00000454359 | RTTN | chr18 | 67817969 | - | 6165 | 1160 | 1824 | 5822 | 1332 |
| ENST00000317133 | ARHGEF7 | chr13 | 111806338 | + | ENST00000437017 | RTTN | chr18 | 67817969 | - | 4013 | 1160 | 710 | 4012 | 1101 |
| ENST00000375741 | ARHGEF7 | chr13 | 111806338 | + | ENST00000255674 | RTTN | chr18 | 67817969 | - | 5612 | 502 | 52 | 5253 | 1733 |
| ENST00000375741 | ARHGEF7 | chr13 | 111806338 | + | ENST00000454359 | RTTN | chr18 | 67817969 | - | 5507 | 502 | 1166 | 5164 | 1332 |
| ENST00000375741 | ARHGEF7 | chr13 | 111806338 | + | ENST00000437017 | RTTN | chr18 | 67817969 | - | 3355 | 502 | 52 | 3354 | 1101 |
| ENST00000370623 | ARHGEF7 | chr13 | 111806338 | + | ENST00000255674 | RTTN | chr18 | 67817969 | - | 5362 | 252 | 0 | 5003 | 1667 |
| ENST00000370623 | ARHGEF7 | chr13 | 111806338 | + | ENST00000454359 | RTTN | chr18 | 67817969 | - | 5257 | 252 | 916 | 4914 | 1332 |
| ENST00000370623 | ARHGEF7 | chr13 | 111806338 | + | ENST00000437017 | RTTN | chr18 | 67817969 | - | 3105 | 252 | 0 | 3104 | 1034 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000317133 | ENST00000255674 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - | 0.000906342 | 0.99909365 |
| ENST00000317133 | ENST00000454359 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - | 0.003574578 | 0.99642545 |
| ENST00000317133 | ENST00000437017 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - | 0.000768309 | 0.9992317 |
| ENST00000375741 | ENST00000255674 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - | 0.000414362 | 0.9995857 |
| ENST00000375741 | ENST00000454359 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - | 0.001672055 | 0.9983279 |
| ENST00000375741 | ENST00000437017 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - | 0.000280236 | 0.9997198 |
| ENST00000370623 | ENST00000255674 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - | 0.0002708 | 0.9997292 |
| ENST00000370623 | ENST00000454359 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - | 0.00110542 | 0.99889463 |
| ENST00000370623 | ENST00000437017 | ARHGEF7 | chr13 | 111806338 | + | RTTN | chr18 | 67817969 | - | 0.000171359 | 0.9998286 |
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Fusion Genomic Features for ARHGEF7-RTTN |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for ARHGEF7-RTTN |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:111806338/chr18:67817969) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ARHGEF7 | chr13:111806338 | chr18:67817969 | ENST00000317133 | + | 2 | 19 | 184_243 | 84 | 783.0 | Domain | SH3 |
| Hgene | ARHGEF7 | chr13:111806338 | chr18:67817969 | ENST00000317133 | + | 2 | 19 | 1_133 | 84 | 783.0 | Domain | Calponin-homology (CH) |
| Hgene | ARHGEF7 | chr13:111806338 | chr18:67817969 | ENST00000317133 | + | 2 | 19 | 271_451 | 84 | 783.0 | Domain | DH |
| Hgene | ARHGEF7 | chr13:111806338 | chr18:67817969 | ENST00000317133 | + | 2 | 19 | 473_578 | 84 | 783.0 | Domain | PH |
| Hgene | ARHGEF7 | chr13:111806338 | chr18:67817969 | ENST00000370623 | + | 2 | 19 | 184_243 | 84 | 732.0 | Domain | SH3 |
| Hgene | ARHGEF7 | chr13:111806338 | chr18:67817969 | ENST00000370623 | + | 2 | 19 | 1_133 | 84 | 732.0 | Domain | Calponin-homology (CH) |
| Hgene | ARHGEF7 | chr13:111806338 | chr18:67817969 | ENST00000370623 | + | 2 | 19 | 271_451 | 84 | 732.0 | Domain | DH |
| Hgene | ARHGEF7 | chr13:111806338 | chr18:67817969 | ENST00000370623 | + | 2 | 19 | 473_578 | 84 | 732.0 | Domain | PH |
| Hgene | ARHGEF7 | chr13:111806338 | chr18:67817969 | ENST00000375723 | + | 1 | 17 | 184_243 | 0 | 626.0 | Domain | SH3 |
| Hgene | ARHGEF7 | chr13:111806338 | chr18:67817969 | ENST00000375723 | + | 1 | 17 | 1_133 | 0 | 626.0 | Domain | Calponin-homology (CH) |
| Hgene | ARHGEF7 | chr13:111806338 | chr18:67817969 | ENST00000375723 | + | 1 | 17 | 271_451 | 0 | 626.0 | Domain | DH |
| Hgene | ARHGEF7 | chr13:111806338 | chr18:67817969 | ENST00000375723 | + | 1 | 17 | 473_578 | 0 | 626.0 | Domain | PH |
| Hgene | ARHGEF7 | chr13:111806338 | chr18:67817969 | ENST00000375736 | + | 1 | 20 | 184_243 | 0 | 647.0 | Domain | SH3 |
| Hgene | ARHGEF7 | chr13:111806338 | chr18:67817969 | ENST00000375736 | + | 1 | 20 | 1_133 | 0 | 647.0 | Domain | Calponin-homology (CH) |
| Hgene | ARHGEF7 | chr13:111806338 | chr18:67817969 | ENST00000375736 | + | 1 | 20 | 271_451 | 0 | 647.0 | Domain | DH |
| Hgene | ARHGEF7 | chr13:111806338 | chr18:67817969 | ENST00000375736 | + | 1 | 20 | 473_578 | 0 | 647.0 | Domain | PH |
| Hgene | ARHGEF7 | chr13:111806338 | chr18:67817969 | ENST00000375739 | + | 1 | 18 | 184_243 | 0 | 754.0 | Domain | SH3 |
| Hgene | ARHGEF7 | chr13:111806338 | chr18:67817969 | ENST00000375739 | + | 1 | 18 | 1_133 | 0 | 754.0 | Domain | Calponin-homology (CH) |
| Hgene | ARHGEF7 | chr13:111806338 | chr18:67817969 | ENST00000375739 | + | 1 | 18 | 271_451 | 0 | 754.0 | Domain | DH |
| Hgene | ARHGEF7 | chr13:111806338 | chr18:67817969 | ENST00000375739 | + | 1 | 18 | 473_578 | 0 | 754.0 | Domain | PH |
| Hgene | ARHGEF7 | chr13:111806338 | chr18:67817969 | ENST00000375741 | + | 2 | 20 | 184_243 | 84 | 804.0 | Domain | SH3 |
| Hgene | ARHGEF7 | chr13:111806338 | chr18:67817969 | ENST00000375741 | + | 2 | 20 | 1_133 | 84 | 804.0 | Domain | Calponin-homology (CH) |
| Hgene | ARHGEF7 | chr13:111806338 | chr18:67817969 | ENST00000375741 | + | 2 | 20 | 271_451 | 84 | 804.0 | Domain | DH |
| Hgene | ARHGEF7 | chr13:111806338 | chr18:67817969 | ENST00000375741 | + | 2 | 20 | 473_578 | 84 | 804.0 | Domain | PH |
| Hgene | ARHGEF7 | chr13:111806338 | chr18:67817969 | ENST00000426073 | + | 1 | 20 | 184_243 | 0 | 647.0 | Domain | SH3 |
| Hgene | ARHGEF7 | chr13:111806338 | chr18:67817969 | ENST00000426073 | + | 1 | 20 | 1_133 | 0 | 647.0 | Domain | Calponin-homology (CH) |
| Hgene | ARHGEF7 | chr13:111806338 | chr18:67817969 | ENST00000426073 | + | 1 | 20 | 271_451 | 0 | 647.0 | Domain | DH |
| Hgene | ARHGEF7 | chr13:111806338 | chr18:67817969 | ENST00000426073 | + | 1 | 20 | 473_578 | 0 | 647.0 | Domain | PH |
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Fusion Gene Sequence for ARHGEF7-RTTN |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >6354_6354_1_ARHGEF7-RTTN_ARHGEF7_chr13_111806338_ENST00000317133_RTTN_chr18_67817969_ENST00000255674_length(transcript)=6270nt_BP=1160nt CCCCGAGACGCAGCCAGGCGCCCGGCCCGGCCCGGCCCGGCCCTCTGCACAGCCCCACTTCAGGCCACGCCGTTTCCTTGACCTTCCCCC GGCAGGGTCTGAAGCGTCACCGTCCGTCTAGAGCAGAGTCGCGCAGGCCCCTGCCCTGCCGGTGAGGTCGGCGCCGCGCTCCGGAGAGTC GGTTCCTCCCGATTCAGACCCATATGGCTTCAGATGGAACCATCATTTCTGTTCCGTCATGACCGGCTTGCAAGGTAGCAAAGCGAAACA AACGTCTCGTTTTCAGCCTGTCCCCGCCACCTTGAAATAAAACCGGCAAAAATAAAAAGAGCATTCTGGGAAGTACTTCATCATTTCAAC GCTCACGAATTCAAAACATAAACAAAGGCTTCCGAGTGCCCCGGCCAGGGGCGCGGGGCGCACGGCGGGCCCGGGGCAGGTAAGCGCAGG TGCGCGCCCGCCCCCACCCCCGGCTCCCTCCCCATCCGCTCCCCGCTCCCCTTCCCCTTTCCCTTCCCCGCCCGCTCCCAGCCGCCGCCG CCGCCCCGCGCACGGCCTGGAGCGGAGGCTGCGCAGGGCGCGGGGCGGCGCGGGCCGGGCGCGGGCCGGGCGGACGGCCGCGTCTTTCTT CTCCTGGCGGTGATGTCATTGGGCGACGGCGGCCGAGGCCGGGGGGCGGCGGCGGGCGCCCGCAGGTTCCCGAGCCGCTCCTGAGAAGGC GCCTGACAGCGGGCCGGGGCGCACGGAGAAGCGGGCCGGGCCGGACCTGCTGGGCCGCGCCGAGCCAATCGCCGGCGCCGGCCGCTCGAT GGGCGAGGCGGCGGCGGCGGCGGCGGGGGCCGCGGGCCGGGCCGCCGCTCCGAGGTGAAGGCGCGCGCCCCTCCCCGCCTGCCTCCCGGG CCGCAGCGATGAATTCCGCCGAGCAAACCGTTACGTGGCTCATCACTCTGGGGGTGCTGGAGTCGCCCAAAAAAACCATCTCGGACCCGG AGGGCTTTCTGCAGGCGTCGCTGAAGGATGGGGTGGTCCTCTGCAGGCTGCTGGAGCGCCTGCTCCCCGGGACCATCGAGAAAGTCTACC CCGAGCCCCGGAGCGAGAGCGAGTGCCTGAGCAACATCCGCGAGTTCCTGCGCGGCTGCGGGGCTTCCCTGCGGCTGGAGGAATGTTTAG GTGTCCATAATGTCACTAAACCCGTGTCTTCACTTTGCAATGGAATTCATTTTCTACTTCATCCAAAAGTTCTGTATGAAATCTCTGTAT TTGGCATTCAAGAGCCCGAAAGTGAGGTGAACACTGCTGCCAAGGCCATTCTGTTATACCTGCTTCAGGGACGATTGATGATGACAGCAT TGACCTGGAACAAGTTTATTGAATCTCTCTGTCCTGTCATCCCAATACTACAGGGCTATGCCGACACAGAAGATCCTCTGGGTAACTGCA TTCTCCTTCTAAGCAAAGCAAGTTCTGACACAGAAGAGATGCTTCCGTGTACTACCCGATTAAAGTCCATGCTGCGACTTTTGCTAGTGA AAAAGCCATCGGTCCGTTCGCTAGCATTAAAGCTTTTAGCATTCCATCTTACCAGTGAAGAAGGGGCTGATACAAAGCGTCCTCTAATAG ACGCCAGAGTTCTCTCCAGAGTTACTGATTTATTCATTGGGAAGAAACCTATTGAACTCAGACTGGATGACAGAAGAGAGCTGGTTATTA AGTTGGAGACTGTTGAAAAGGTATATGAAATCTTCACCTCAGATGATGTTGATCTCGTTTTGAGAAAGTCAGCTGCTGAACAGTTAGCTG TGATTATGCAAGATATTAAAATGCATGCTGTGGTGAAAAAGTTATGCTTAATTGACAAAATAATTGAGTATTTAAATGAATGTGTGAGTC AAGATGGCAAGGTTGTAGAATGTTTGGTACAACCATGCCTCACACTCTTGAGGAAGGTTTTATGTGGTGATCCAGTCATGCGTGTTTCGC TCTCGCAACAGTCTTCTCTTTTGACCGTGTTATTCAGAGTTTCCTTAATATTTCATGAAGATTGTAGTGTCGTGACTGAAGTTGGAGCAC TATTTTGTCTTCTATTATTTGATGAAGTATCGAGAATGGATATGTGGTCTGTTAATCCTTCCAATAAACCTTCTTTGCCATCGGTCTTCA GTTTGCCTGTTTCCGTTTTTAGAAGGTACCATCTACCTGTTCATGTAATTGGACACCATGCTGTGAGTCCTTACTCCATAGTTTTGCCCT TATCTGCTGATTGTTTGGCCTTGAAGCCGGTGTCAGATATGCTGAGAATAGCTTGGAACCTGTCATGGTATCATGGGAGTGATAATCTGT TGAAGCAAATGAACTCTGAAACTAAAACGCAAGAAATTTTAGATGCATTGAAGTTATCTACAGAGGACATCCTCACTCTGAAGATAACAC ACATGGCTAGTGGGCTGCAGGACTGCCTCCATTCCATTGTTCAGGCTGCAACCCACAGGGAAGTTAGGGCTGCTGTCACCAGGATGAGTT TTTATCTTCTGAATGACAGATTGTCTTTAAAGGGTTGCCCTGGTCCATGTGGGGTTACCTTGAAGTCCTTGGCTTGGCACACCGCACTAA ACAGGTTTTTACAGGTGCTTCCTGCTTGCACTGAAGATGAGAAACTGCTAATAGATATCATACATTTTTTAAATAAATTAATAAAGGAAC AAAGAAAAAATTCTTCACTAGAACTTCTAAACTGGATTCTCGAATTACTTCTTAGACATAGTGCAAACCCACTGTTAGACCTCTTGGTTC TGACAGAGTCACAGGCACGAGAAGAAACAGATGATATCCGGACTGCTGTCAGGCAACAACTTCAGAAAGAACTGATTGCTCTTTTTGATA CCTTGCTGCTCAATTTCATGGAAGTTACTGACAGGAAATGCTCGGAACTTCTTTACGTTTTTCAAACGCAGCTGGCTCTGAAACTGCTCC AGTGTCTGAAAGTGACGGATGCGCCTCATTTCTATGGCCTGCCGTCCCTTGAGCGGACCTTACGAGGGATGGCTAACCTCACTGCGTTTC CGGGATGGAGCTCACACTCTCCTCTCACAAAGCCTCTAGATATCTGTGTGAAGTACTTGTCAGGTCTCCTTGAGGTCATTACTTCTTTTT ATGTGGAGCGTGGAGGAAATGCTATGTCCTTCATGGGAAAAGGTGTTACAAAGAGCACAATTCTTTGCTTGCTTCACTTATCCCATGAGA TGATGGCCCAGGCTGGGAGCTTGGAGTGGATGTCACTTTGGTTCTTGCCTTTGGGTAGTCATAGTGAAGAACATATTCCTACTCAACAAG GATTGGCTTGGTTGATTCCATTATGGGTTGATCGGGACCCAGAGGTGAGATTCACTTCACTGGGATTAGGATCAGCACTGACCACCCTTG AAACGGGCTGTGTGGCCTTAGCAAACAGTTGTCAGAACATTTCCGGTGGGCTCTGGGGAACTGTGGTGAACATTCTTCTGGACCAGTCAG AATGTAGTATGGTGCGCCGGGAGGCGGCATTTATTCTTCAGAATCTCCTTGTAATTCCAATGCCTACAGAAATTATAAAGGATTATACTT GGCAGGGTCCCTGTGTTCATGATGAGGACTCTGGCCTATCGCTCATTGGAAAACCTGCCCTTCAGGCTCTTTTATATCACTGCCATTTTT ATGAACATTTGAATCAGATGGTAAAGCATTGTTACCTAGGACGGTGTATGTTTGATTTGAATTTTTCTGCTTTTGATAGAAATTCAGAAA GCAATGATTTAAATGGTTTAGATGACTCATTCAAGTTTTGGAGGGCTCCATCTAGGACAAGTCAGGATCGAGATCCAAGTTCTCTCTCCA CCTCAGAAACAACGGTGGCACCTTCATTGGGGAGTACTGAATTTCAGCCACTTGTGCAGTCAACAACACTTCTACCTGAAGCCTCCCATG ACCAGTTTGTGGCTCAAGGTCACCAGGAAAGTACATCACCACGGCCACCTCATGATTCATCTCTTTCTGCTCCCCTGCCCAAACTGTGTG TTTTTGTTACTCCATCTCTTCTTTCAGCAATGTGCAGCCTCTTGGACAACCTCTTGACGATTGCTCCCAGAGACACTGCAAAGGCTTTTC GACAAGCTCATCTCATAGAACTTCTCTGTAGCATTGCAGATGCTACCCTCATACAGACATGTGTCCAGGAACTCAGAGCCCTGCTGCCTT CATCACCTCCAGCTGAACACACTCAGGCTCAGGTTTCCTTTCTCCTGGAATACCTATCCTCTTTGTCCAGGCTTCTGCAGTCATGTTTAT TGGTGGAGCCTGACCTTGTGATTCAGGATGAGCTTGTGAAACCTCTTATCACCAATATCATTGGAATTCTCACCATATGTACCAAAGATG TATTAGATAAAGAGTTAATATCAGCTTTTTATCACACATGGACACATTTATTTAATCTTCTGGCCATGCTCCTGAGGAAAGCTGGTGCCA TCACACTCCCGTTTGTTACCGTGGCCCTGGCCAAGCACTGGACAGCGGCGATTGATATGTTCTGCACATGTGCAGGCTTGTCTGCCACGT GTCCTGCCCTGTATACTGCCAGCTTGCAATTCCTTTCTGTTCTCTTGACCGAAGAAGCAAAAGGGCATCTCCAGGCTAAGAGCAAAACAC ATTTATGCTGTAGTCCAACAGTGGCTTCACTTCTTGATGACTCTCAGGAAAATCAGAAATCTCTAGAACAACTTAGTGATGTAATCCTTC AGTGCTATGAAGGGAAATCCTCCAAAGATATCCTGAAAAGAGTAGCTGCAAATGCATTGATGTCACTGCTGGCTGTCAGTAGAAGAGCAC AGAAACATGCTTTGAAAGCCAATCTTATAGACAATTGCATGGAGCAGATGAAACACATAAATGCACAACTGAACCTAGATTCTCTGAGGC CTGGGAAAGCAGCATTGAAAAAAAAGGAGGATGGTGTTATTAAAGAGTTAAGCATTGCCATGCAGCTCCTAAGAAACTGTCTTTATCAAA ATGAGGAATGTAAAGAAGCAGCTCTTGAAGCTCACCTTGTCCCTGTCTTGCACTCTCTCTGGCCTTGGATTTTGATGGATGATTCATTGA TGCAAATTTCTCTGCAGCTCCTTTGTGTCTATACTGCAAATTTTCCAAATGGTTGCAGTTCTCTTTGTTGGTCAAGTTGTGGACAACACC CTGTTCAAGCTACACATAGAGGAGCCGTGAGCAACTCTCTGATGCTGTGTATCCTAAAGTTGGCTTCCCAGATGCCACTGGAGAACACCA CGGTTCAGCAGATGGTTTTTATGCTTCTTTCAAACCTGGCCTTGTCGCATGACTGTAAAGGAGTAATTCAGAAGAGTAACTTCTTACAGA ACTTCCTCTCTCTAGCATTGCCAAAAGGAGGAAATAAACATCTAAGTAATCTGACTATTCTTTGGTTGAAGTTACTCCTGAATATATCAT CTGGAGAAGATGGGCAACAAATGATTCTGAGGCTTGATGGCTGTCTAGACTTACTAACAGAGATGAGCAAATACAAGCACAAGAGCAGCC CTTTATTGCCTCTTCTTATCTTTCATAATGTTTGCTTCAGTCCTGCAAATAAACCCAAGATCCTGGCTAATGAAAAAGTCATTACTGTGC TTGCTGCCTGTCTGGAAAGTGAGAATCAAAATGCTCAGAGGATTGGAGCAGCTGCCCTTTGGGCTCTGATTTACAATTATCAGAAGGCAA AAACAGCTTTGAAAAGCCCATCAGTAAAAAGAAGAGTGGATGAAGCATACTCCTTAGCAAAGAAAACTTTCCCAAACTCAGAAGCAAACC CTCTAAATGCCTATTATTTGAAATGTCTTGAAAACCTCGTGCAGCTCCTTAATTCTTCCTGAGTGCCATGGGATGCTACACCTTGAAGCT GACAGTCATCAACAGGGGAGCTAAAGTTGAAGCCAGCTGTGTGTAGCAGCTGTTACCTGAAGACGTGCTACCTCTCTACAAAGTGTTGAT CCCCTTCTTTCCCATGAGAGAGAGAACTGGTGATACTCCAACACCGTCCAGTTGTGGCAGCTCTCCAGAAGTAATAGCAGCTGACAACTT TCTGTGCCTTTTCCTTTCTGTTGAAAAGGCATAGAAAGTTCTGGGAACATAAACATTTTTACCCTTTTCTATGCCATTTATTTTGTAAAA >6354_6354_1_ARHGEF7-RTTN_ARHGEF7_chr13_111806338_ENST00000317133_RTTN_chr18_67817969_ENST00000255674_length(amino acids)=1733AA_BP=148 MRRRLTAGRGARRSGPGRTCWAAPSQSPAPAARWARRRRRRRGPRAGPPLRGEGARPSPPASRAAAMNSAEQTVTWLITLGVLESPKKTI SDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEPRSESECLSNIREFLRGCGASLRLEECLGVHNVTKPVSSLCNGIHFLLHPKVLYE ISVFGIQEPESEVNTAAKAILLYLLQGRLMMTALTWNKFIESLCPVIPILQGYADTEDPLGNCILLLSKASSDTEEMLPCTTRLKSMLRL LLVKKPSVRSLALKLLAFHLTSEEGADTKRPLIDARVLSRVTDLFIGKKPIELRLDDRRELVIKLETVEKVYEIFTSDDVDLVLRKSAAE QLAVIMQDIKMHAVVKKLCLIDKIIEYLNECVSQDGKVVECLVQPCLTLLRKVLCGDPVMRVSLSQQSSLLTVLFRVSLIFHEDCSVVTE VGALFCLLLFDEVSRMDMWSVNPSNKPSLPSVFSLPVSVFRRYHLPVHVIGHHAVSPYSIVLPLSADCLALKPVSDMLRIAWNLSWYHGS DNLLKQMNSETKTQEILDALKLSTEDILTLKITHMASGLQDCLHSIVQAATHREVRAAVTRMSFYLLNDRLSLKGCPGPCGVTLKSLAWH TALNRFLQVLPACTEDEKLLIDIIHFLNKLIKEQRKNSSLELLNWILELLLRHSANPLLDLLVLTESQAREETDDIRTAVRQQLQKELIA LFDTLLLNFMEVTDRKCSELLYVFQTQLALKLLQCLKVTDAPHFYGLPSLERTLRGMANLTAFPGWSSHSPLTKPLDICVKYLSGLLEVI TSFYVERGGNAMSFMGKGVTKSTILCLLHLSHEMMAQAGSLEWMSLWFLPLGSHSEEHIPTQQGLAWLIPLWVDRDPEVRFTSLGLGSAL TTLETGCVALANSCQNISGGLWGTVVNILLDQSECSMVRREAAFILQNLLVIPMPTEIIKDYTWQGPCVHDEDSGLSLIGKPALQALLYH CHFYEHLNQMVKHCYLGRCMFDLNFSAFDRNSESNDLNGLDDSFKFWRAPSRTSQDRDPSSLSTSETTVAPSLGSTEFQPLVQSTTLLPE ASHDQFVAQGHQESTSPRPPHDSSLSAPLPKLCVFVTPSLLSAMCSLLDNLLTIAPRDTAKAFRQAHLIELLCSIADATLIQTCVQELRA LLPSSPPAEHTQAQVSFLLEYLSSLSRLLQSCLLVEPDLVIQDELVKPLITNIIGILTICTKDVLDKELISAFYHTWTHLFNLLAMLLRK AGAITLPFVTVALAKHWTAAIDMFCTCAGLSATCPALYTASLQFLSVLLTEEAKGHLQAKSKTHLCCSPTVASLLDDSQENQKSLEQLSD VILQCYEGKSSKDILKRVAANALMSLLAVSRRAQKHALKANLIDNCMEQMKHINAQLNLDSLRPGKAALKKKEDGVIKELSIAMQLLRNC LYQNEECKEAALEAHLVPVLHSLWPWILMDDSLMQISLQLLCVYTANFPNGCSSLCWSSCGQHPVQATHRGAVSNSLMLCILKLASQMPL ENTTVQQMVFMLLSNLALSHDCKGVIQKSNFLQNFLSLALPKGGNKHLSNLTILWLKLLLNISSGEDGQQMILRLDGCLDLLTEMSKYKH KSSPLLPLLIFHNVCFSPANKPKILANEKVITVLAACLESENQNAQRIGAAALWALIYNYQKAKTALKSPSVKRRVDEAYSLAKKTFPNS -------------------------------------------------------------- >6354_6354_2_ARHGEF7-RTTN_ARHGEF7_chr13_111806338_ENST00000317133_RTTN_chr18_67817969_ENST00000437017_length(transcript)=4013nt_BP=1160nt CCCCGAGACGCAGCCAGGCGCCCGGCCCGGCCCGGCCCGGCCCTCTGCACAGCCCCACTTCAGGCCACGCCGTTTCCTTGACCTTCCCCC GGCAGGGTCTGAAGCGTCACCGTCCGTCTAGAGCAGAGTCGCGCAGGCCCCTGCCCTGCCGGTGAGGTCGGCGCCGCGCTCCGGAGAGTC GGTTCCTCCCGATTCAGACCCATATGGCTTCAGATGGAACCATCATTTCTGTTCCGTCATGACCGGCTTGCAAGGTAGCAAAGCGAAACA AACGTCTCGTTTTCAGCCTGTCCCCGCCACCTTGAAATAAAACCGGCAAAAATAAAAAGAGCATTCTGGGAAGTACTTCATCATTTCAAC GCTCACGAATTCAAAACATAAACAAAGGCTTCCGAGTGCCCCGGCCAGGGGCGCGGGGCGCACGGCGGGCCCGGGGCAGGTAAGCGCAGG TGCGCGCCCGCCCCCACCCCCGGCTCCCTCCCCATCCGCTCCCCGCTCCCCTTCCCCTTTCCCTTCCCCGCCCGCTCCCAGCCGCCGCCG CCGCCCCGCGCACGGCCTGGAGCGGAGGCTGCGCAGGGCGCGGGGCGGCGCGGGCCGGGCGCGGGCCGGGCGGACGGCCGCGTCTTTCTT CTCCTGGCGGTGATGTCATTGGGCGACGGCGGCCGAGGCCGGGGGGCGGCGGCGGGCGCCCGCAGGTTCCCGAGCCGCTCCTGAGAAGGC GCCTGACAGCGGGCCGGGGCGCACGGAGAAGCGGGCCGGGCCGGACCTGCTGGGCCGCGCCGAGCCAATCGCCGGCGCCGGCCGCTCGAT GGGCGAGGCGGCGGCGGCGGCGGCGGGGGCCGCGGGCCGGGCCGCCGCTCCGAGGTGAAGGCGCGCGCCCCTCCCCGCCTGCCTCCCGGG CCGCAGCGATGAATTCCGCCGAGCAAACCGTTACGTGGCTCATCACTCTGGGGGTGCTGGAGTCGCCCAAAAAAACCATCTCGGACCCGG AGGGCTTTCTGCAGGCGTCGCTGAAGGATGGGGTGGTCCTCTGCAGGCTGCTGGAGCGCCTGCTCCCCGGGACCATCGAGAAAGTCTACC CCGAGCCCCGGAGCGAGAGCGAGTGCCTGAGCAACATCCGCGAGTTCCTGCGCGGCTGCGGGGCTTCCCTGCGGCTGGAGGAATGTTTAG GTGTCCATAATGTCACTAAACCCGTGTCTTCACTTTGCAATGGAATTCATTTTCTACTTCATCCAAAAGTTCTGTATGAAATCTCTGTAT TTGGCATTCAAGAGCCCGAAAGTGAGGTGAACACTGCTGCCAAGGCCATTCTGTTATACCTGCTTCAGGGACGATTGATGATGACAGCAT TGACCTGGAACAAGTTTATTGAATCTCTCTGTCCTGTCATCCCAATACTACAGGGCTATGCCGACACAGAAGATCCTCTGGGTAACTGCA TTCTCCTTCTAAGCAAAGCAAGTTCTGACACAGAAGAGATGCTTCCGTGTACTACCCGATTAAAGTCCATGCTGCGACTTTTGCTAGTGA AAAAGCCATCGGTCCGTTCGCTAGCATTAAAGCTTTTAGCATTCCATCTTACCAGTGAAGAAGGGGCTGATACAAAGCGTCCTCTAATAG ACGCCAGAGTTCTCTCCAGAGTTACTGATTTATTCATTGGGAAGAAACCTATTGAACTCAGACTGGATGACAGAAGAGAGCTGGTTATTA AGTTGGAGACTGTTGAAAAGGTATATGAAATCTTCACCTCAGATGATGTTGATCTCGTTTTGAGAAAGTCAGCTGCTGAACAGTTAGCTG TGATTATGCAAGATATTAAAATGCATGCTGTGGTGAAAAAGTTATGCTTAATTGACAAAATAATTGAGTATTTAAATGAATGTGTGAGTC AAGATGGCAAGGTTGTAGAATGTTTGGTACAACCATGCCTCACACTCTTGAGGAAGGTTTTATGTGGTGATCCAGTCATGCGTGTTTCGC TCTCGCAACAGTCTTCTCTTTTGACCGTGTTATTCAGAGTTTCCTTAATATTTCATGAAGATTGTAGTGTCGTGACTGAAGTTGGAGCAC TATTTTGTCTTCTATTATTTGATGAAGTATCGAGAATGGATATGTGGTCTGTTAATCCTTCCAATAAACCTTCTTTGCCATCGGTCTTCA GTTTGCCTGTTTCCGTTTTTAGAAGGTACCATCTACCTGTTCATGTAATTGGACACCATGCTGTGAGTCCTTACTCCATAGTTTTGCCCT TATCTGCTGATTGTTTGGCCTTGAAGCCGGTGTCAGATATGCTGAGAATAGCTTGGAACCTGTCATGGTATCATGGGAGTGATAATCTGT TGAAGCAAATGAACTCTGAAACTAAAACGCAAGAAATTTTAGATGCATTGAAGTTATCTACAGAGGACATCCTCACTCTGAAGATAACAC ACATGGCTAGTGGGCTGCAGGACTGCCTCCATTCCATTGTTCAGGCTGCAACCCACAGGGAAGTTAGGGCTGCTGTCACCAGGATGAGTT TTTATCTTCTGAATGACAGATTGTCTTTAAAGGGTTGCCCTGGTCCATGTGGGGTTACCTTGAAGTCCTTGGCTTGGCACACCGCACTAA ACAGGTTTTTACAGGTGCTTCCTGCTTGCACTGAAGATGAGAAACTGCTAATAGATATCATACATTTTTTAAATAAATTAATAAAGGAAC AAAGAAAAAATTCTTCACTAGAACTTCTAAACTGGATTCTCGAATTACTTCTTAGACATAGTGCAAACCCACTGTTAGACCTCTTGGTTC TGACAGAGTCACAGGCACGAGAAGAAACAGATGATATCCGGACTGCTGTCAGGCAACAACTTCAGAAAGAACTGATTGCTCTTTTTGATA CCTTGCTGCTCAATTTCATGGAAGTTACTGACAGGAAATGCTCGGAACTTCTTTACGTTTTTCAAACGCAGCTGGCTCTGAAACTGCTCC AGTGTCTGAAAGTGACGGATGCGCCTCATTTCTATGGCCTGCCGTCCCTTGAGCGGACCTTACGAGGGATGGCTAACCTCACTGCGTTTC CGGGATGGAGCTCACACTCTCCTCTCACAAAGCCTCTAGATATCTGTGTGAAGTACTTGTCAGGTCTCCTTGAGGTCATTACTTCTTTTT ATGTGGAGCGTGGAGGAAATGCTATGTCCTTCATGGGAAAAGGTGTTACAAAGAGCACAATTCTTTGCTTGCTTCACTTATCCCATGAGA TGATGGCCCAGGCTGGGAGCTTGGAGTGGATGTCACTTTGGTTCTTGCCTTTGGGTAGTCATAGTGAAGAACATATTCCTACTCAACAAG GATTGGCTTGGTTGATTCCATTATGGGTTGATCGGGACCCAGAGGTGAGATTCACTTCACTGGGATTAGGATCAGCACTGACCACCCTTG AAACGGGCTGTGTGGCCTTAGCAAACAGTTGTCAGAACATTTCCGGTGGGCTCTGGGGAACTGTGGTGAACATTCTTCTGGACCAGTCAG AATGTAGTATGGTGCGCCGGGAGGCGGCATTTATTCTTCAGAATCTCCTTGTAATTCCAATGCCTACAGAAATTATAAAGGATTATACTT GGCAGGGTCCCTGTGTTCATGATGAGGACTCTGGCCTATCGCTCATTGGAAAACCTGCCCTTCAGGCTCTTTTATATCACTGCCATTTTT ATGAACATTTGAATCAGATGGTAAAGCATTGTTACCTAGGACGGTGTATGTTTGATTTGAATTTTTCTGCTTTTGATAGAAATTCAGAAA GCAATGATTTAAATGGTTTAGATGACTCATTCAAGTTTTGGAGGGCTCCATCTAGGACAAGTCAGGATCGAGATCCAAGTTCTCTCTCCA CCTCAGAAACAACGGTGGCACCTTCATTGGGGAGTACTGAATTTCAGCCACTTGTGCAGTCAACAACACTTCTACCTGAAGCCTCCCATG >6354_6354_2_ARHGEF7-RTTN_ARHGEF7_chr13_111806338_ENST00000317133_RTTN_chr18_67817969_ENST00000437017_length(amino acids)=1101AA_BP=148 MRRRLTAGRGARRSGPGRTCWAAPSQSPAPAARWARRRRRRRGPRAGPPLRGEGARPSPPASRAAAMNSAEQTVTWLITLGVLESPKKTI SDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEPRSESECLSNIREFLRGCGASLRLEECLGVHNVTKPVSSLCNGIHFLLHPKVLYE ISVFGIQEPESEVNTAAKAILLYLLQGRLMMTALTWNKFIESLCPVIPILQGYADTEDPLGNCILLLSKASSDTEEMLPCTTRLKSMLRL LLVKKPSVRSLALKLLAFHLTSEEGADTKRPLIDARVLSRVTDLFIGKKPIELRLDDRRELVIKLETVEKVYEIFTSDDVDLVLRKSAAE QLAVIMQDIKMHAVVKKLCLIDKIIEYLNECVSQDGKVVECLVQPCLTLLRKVLCGDPVMRVSLSQQSSLLTVLFRVSLIFHEDCSVVTE VGALFCLLLFDEVSRMDMWSVNPSNKPSLPSVFSLPVSVFRRYHLPVHVIGHHAVSPYSIVLPLSADCLALKPVSDMLRIAWNLSWYHGS DNLLKQMNSETKTQEILDALKLSTEDILTLKITHMASGLQDCLHSIVQAATHREVRAAVTRMSFYLLNDRLSLKGCPGPCGVTLKSLAWH TALNRFLQVLPACTEDEKLLIDIIHFLNKLIKEQRKNSSLELLNWILELLLRHSANPLLDLLVLTESQAREETDDIRTAVRQQLQKELIA LFDTLLLNFMEVTDRKCSELLYVFQTQLALKLLQCLKVTDAPHFYGLPSLERTLRGMANLTAFPGWSSHSPLTKPLDICVKYLSGLLEVI TSFYVERGGNAMSFMGKGVTKSTILCLLHLSHEMMAQAGSLEWMSLWFLPLGSHSEEHIPTQQGLAWLIPLWVDRDPEVRFTSLGLGSAL TTLETGCVALANSCQNISGGLWGTVVNILLDQSECSMVRREAAFILQNLLVIPMPTEIIKDYTWQGPCVHDEDSGLSLIGKPALQALLYH CHFYEHLNQMVKHCYLGRCMFDLNFSAFDRNSESNDLNGLDDSFKFWRAPSRTSQDRDPSSLSTSETTVAPSLGSTEFQPLVQSTTLLPE -------------------------------------------------------------- >6354_6354_3_ARHGEF7-RTTN_ARHGEF7_chr13_111806338_ENST00000317133_RTTN_chr18_67817969_ENST00000454359_length(transcript)=6165nt_BP=1160nt CCCCGAGACGCAGCCAGGCGCCCGGCCCGGCCCGGCCCGGCCCTCTGCACAGCCCCACTTCAGGCCACGCCGTTTCCTTGACCTTCCCCC GGCAGGGTCTGAAGCGTCACCGTCCGTCTAGAGCAGAGTCGCGCAGGCCCCTGCCCTGCCGGTGAGGTCGGCGCCGCGCTCCGGAGAGTC GGTTCCTCCCGATTCAGACCCATATGGCTTCAGATGGAACCATCATTTCTGTTCCGTCATGACCGGCTTGCAAGGTAGCAAAGCGAAACA AACGTCTCGTTTTCAGCCTGTCCCCGCCACCTTGAAATAAAACCGGCAAAAATAAAAAGAGCATTCTGGGAAGTACTTCATCATTTCAAC GCTCACGAATTCAAAACATAAACAAAGGCTTCCGAGTGCCCCGGCCAGGGGCGCGGGGCGCACGGCGGGCCCGGGGCAGGTAAGCGCAGG TGCGCGCCCGCCCCCACCCCCGGCTCCCTCCCCATCCGCTCCCCGCTCCCCTTCCCCTTTCCCTTCCCCGCCCGCTCCCAGCCGCCGCCG CCGCCCCGCGCACGGCCTGGAGCGGAGGCTGCGCAGGGCGCGGGGCGGCGCGGGCCGGGCGCGGGCCGGGCGGACGGCCGCGTCTTTCTT CTCCTGGCGGTGATGTCATTGGGCGACGGCGGCCGAGGCCGGGGGGCGGCGGCGGGCGCCCGCAGGTTCCCGAGCCGCTCCTGAGAAGGC GCCTGACAGCGGGCCGGGGCGCACGGAGAAGCGGGCCGGGCCGGACCTGCTGGGCCGCGCCGAGCCAATCGCCGGCGCCGGCCGCTCGAT GGGCGAGGCGGCGGCGGCGGCGGCGGGGGCCGCGGGCCGGGCCGCCGCTCCGAGGTGAAGGCGCGCGCCCCTCCCCGCCTGCCTCCCGGG CCGCAGCGATGAATTCCGCCGAGCAAACCGTTACGTGGCTCATCACTCTGGGGGTGCTGGAGTCGCCCAAAAAAACCATCTCGGACCCGG AGGGCTTTCTGCAGGCGTCGCTGAAGGATGGGGTGGTCCTCTGCAGGCTGCTGGAGCGCCTGCTCCCCGGGACCATCGAGAAAGTCTACC CCGAGCCCCGGAGCGAGAGCGAGTGCCTGAGCAACATCCGCGAGTTCCTGCGCGGCTGCGGGGCTTCCCTGCGGCTGGAGGAATGTTTAG GTGTCCATAATGTCACTAAACCCGTGTCTTCACTTTGCAATGGAATTCATTTTCTACTTCATCCAAAAGTTCTGTATGAAATCTCTGTAT TTGGCATTCAAGAGCCCGAAAGTGAGGTGAACACTGCTGCCAAGGCCATTCTGTTATACCTGCTTCAGGGACGATTGATGATGACAGCAT TGACCTGGAACAAGTTTATTGAATCTCTCTGTCCTGTCATCCCAATACTACAGGGCTATGCCGACACAGAAGATCCTCTGGGTAACTGCA TTCTCCTTCTAAGCAAAGCAAGTTCTGACACAGAAGAGATGCTTCCGTGTACTACCCGATTAAAGTCCATGCTGCGACTTTTGCTAGTGA AAAAGCCATCGGTCCGTTCGCTAGCATTAAAGCTTTTAGCATTCCATCTTACCAGTGAAGAAGGGGCTGATACAAAGCGTCCTCTAATAG ACGCCAGAGTTCTCTCCAGAGTTACTGATTTATTCATTGGGAAGAAACCTATTGAACTCAGACTGGATGACAGAAGAGAGCTGGTTATTA AGTTGGAGACTGTTGAAAAGGTATATGAAATCTTCACCTCAGATGATGTTGATCTCGTTTTGAGAAAGTCAGCTGCTGAACAGTTAGCTG TGATTATGCAAGGTTGTAGAATGTTTGGTACAACCATGCCTCACACTCTTGAGGAAGGTTTTATGTGGTGATCCAGTCATGCGTGTTTCG CTCTCGCAACAGTCTTCTCTTTTGACCGTGTTATTCAGAGTTTCCTTAATATTTCATGAAGATTGTAGTGTCGTGACTGAAGTTGGAGCA CTATTTTGTCTTCTATTATTTGATGAAGTATCGAGAATGGATATGTGGTCTGTTAATCCTTCCAATAAACCTTCTTTGCCATCGGTCTTC AGTTTGCCTGTTTCCGTTTTTAGAAGGTACCATCTACCTGTTCATGTAATTGGACACCATGCTGTGAGTCCTTACTCCATAGTTTTGCCC TTATCTGCTGATTGTTTGGCCTTGAAGCCGGTGTCAGATATGCTGAGAATAGCTTGGAACCTGTCATGGTATCATGGGAGTGATAATCTG TTGAAGCAAATGAACTCTGAAACTAAAACGCAAGAAATTTTAGATGCATTGAAGTTATCTACAGAGGACATCCTCACTCTGAAGATAACA CACATGGCTAGTGGGCTGCAGGACTGCCTCCATTCCATTGTTCAGGCTGCAACCCACAGGGAAGTTAGGGCTGCTGTCACCAGGATGAGT TTTTATCTTCTGAATGACAGATTGTCTTTAAAGGGTTGCCCTGGTCCATGTGGGGTTACCTTGAAGTCCTTGGCTTGGCACACCGCACTA AACAGGTTTTTACAGGTGCTTCCTGCTTGCACTGAAGATGAGAAACTGCTAATAGATATCATACATTTTTTAAATAAATTAATAAAGGAA CAAAGAAAAAATTCTTCACTAGAACTTCTAAACTGGATTCTCGAATTACTTCTTAGACATAGTGCAAACCCACTGTTAGACCTCTTGGTT CTGACAGAGTCACAGGCACGAGAAGAAACAGATGATATCCGGACTGCTGTCAGGCAACAACTTCAGAAAGAACTGATTGCTCTTTTTGAT ACCTTGCTGCTCAATTTCATGGAAGTTACTGACAGGAAATGCTCGGAACTTCTTTACGTTTTTCAAACGCAGCTGGCTCTGAAACTGCTC CAGTGTCTGAAAGTGACGGATGCGCCTCATTTCTATGGCCTGCCGTCCCTTGAGCGGACCTTACGAGGGATGGCTAACCTCACTGCGTTT CCGGGATGGAGCTCACACTCTCCTCTCACAAAGCCTCTAGATATCTGTGTGAAGTACTTGTCAGGTCTCCTTGAGGTCATTACTTCTTTT TATGTGGAGCGTGGAGGAAATGCTATGTCCTTCATGGGAAAAGGTGTTACAAAGAGCACAATTCTTTGCTTGCTTCACTTATCCCATGAG ATGATGGCCCAGGCTGGGAGCTTGGAGTGGATGTCACTTTGGTTCTTGCCTTTGGGTAGTCATAGTGAAGAACATATTCCTACTCAACAA GGATTGGCTTGGTTGATTCCATTATGGGTTGATCGGGACCCAGAGGTGAGATTCACTTCACTGGGATTAGGATCAGCACTGACCACCCTT GAAACGGGCTGTGTGGCCTTAGCAAACAGTTGTCAGAACATTTCCGGTGGGCTCTGGGGAACTGTGGTGAACATTCTTCTGGACCAGTCA GAATGTAGTATGGTGCGCCGGGAGGCGGCATTTATTCTTCAGAATCTCCTTGTAATTCCAATGCCTACAGAAATTATAAAGGATTATACT TGGCAGGGTCCCTGTGTTCATGATGAGGACTCTGGCCTATCGCTCATTGGAAAACCTGCCCTTCAGGCTCTTTTATATCACTGCCATTTT TATGAACATTTGAATCAGATGGTAAAGCATTGTTACCTAGGACGGTGTATGTTTGATTTGAATTTTTCTGCTTTTGATAGAAATTCAGAA AGCAATGATTTAAATGGTTTAGATGACTCATTCAAGTTTTGGAGGGCTCCATCTAGGACAAGTCAGGATCGAGATCCAAGTTCTCTCTCC ACCTCAGAAACAACGGTGGCACCTTCATTGGGGAGTACTGAATTTCAGCCACTTGTGCAGTCAACAACACTTCTACCTGAAGCCTCCCAT GACCAGTTTGTGGCTCAAGGTCACCAGGAAAGTACATCACCACGGCCACCTCATGATTCATCTCTTTCTGCTCCCCTGCCCAAACTGTGT GTTTTTGTTACTCCATCTCTTCTTTCAGCAATGTGCAGCCTCTTGGACAACCTCTTGACGATTGCTCCCAGAGACACTGCAAAGGCTTTT CGACAAGCTCATCTCATAGAACTTCTCTGTAGCATTGCAGATGCTACCCTCATACAGACATGTGTCCAGGAACTCAGAGCCCTGCTGCCT TCATCACCTCCAGCTGAACACACTCAGGCTCAGGTTTCCTTTCTCCTGGAATACCTATCCTCTTTGTCCAGGCTTCTGCAGTCATGTTTA TTGGTGGAGCCTGACCTTGTGATTCAGGATGAGCTTGTGAAACCTCTTATCACCAATATCATTGGAATTCTCACCATATGTACCAAAGAT GTATTAGATAAAGAGTTAATATCAGCTTTTTATCACACATGGACACATTTATTTAATCTTCTGGCCATGCTCCTGAGGAAAGCTGGTGCC ATCACACTCCCGTTTGTTACCGTGGCCCTGGCCAAGCACTGGACAGCGGCGATTGATATGTTCTGCACATGTGCAGGCTTGTCTGCCACG TGTCCTGCCCTGTATACTGCCAGCTTGCAATTCCTTTCTGTTCTCTTGACCGAAGAAGCAAAAGGGCATCTCCAGGCTAAGAGCAAAACA CATTTATGCTGTAGTCCAACAGTGGCTTCACTTCTTGATGACTCTCAGGAAAATCAGAAATCTCTAGAACAACTTAGTGATGTAATCCTT CAGTGCTATGAAGGGAAATCCTCCAAAGATATCCTGAAAAGAGTAGCTGCAAATGCATTGATGTCACTGCTGGCTGTCAGTAGAAGAGCA CAGAAACATGCTTTGAAAGCCAATCTTATAGACAATTGCATGGAGCAGATGAAACACATAAATGCACAACTGAACCTAGATTCTCTGAGG CCTGGGAAAGCAGCATTGAAAAAAAAGGAGGATGGTGTTATTAAAGAGTTAAGCATTGCCATGCAGCTCCTAAGAAACTGTCTTTATCAA AATGAGGAATGTAAAGAAGCAGCTCTTGAAGCTCACCTTGTCCCTGTCTTGCACTCTCTCTGGCCTTGGATTTTGATGGATGATTCATTG ATGCAAATTTCTCTGCAGCTCCTTTGTGTCTATACTGCAAATTTTCCAAATGGTTGCAGTTCTCTTTGTTGGTCAAGTTGTGGACAACAC CCTGTTCAAGCTACACATAGAGGAGCCGTGAGCAACTCTCTGATGCTGTGTATCCTAAAGTTGGCTTCCCAGATGCCACTGGAGAACACC ACGGTTCAGCAGATGGTTTTTATGCTTCTTTCAAACCTGGCCTTGTCGCATGACTGTAAAGGAGTAATTCAGAAGAGTAACTTCTTACAG AACTTCCTCTCTCTAGCATTGCCAAAAGGAGGAAATAAACATCTAAGTAATCTGACTATTCTTTGGTTGAAGTTACTCCTGAATATATCA TCTGGAGAAGATGGGCAACAAATGATTCTGAGGCTTGATGGCTGTCTAGACTTACTAACAGAGATGAGCAAATACAAGCACAAGAGCAGC CCTTTATTGCCTCTTCTTATCTTTCATAATGTTTGCTTCAGTCCTGCAAATAAACCCAAGATCCTGGCTAATGAAAAAGTCATTACTGTG CTTGCTGCCTGTCTGGAAAGTGAGAATCAAAATGCTCAGAGGATTGGAGCAGCTGCCCTTTGGGCTCTGATTTACAATTATCAGAAGGCA AAAACAGCTTTGAAAAGCCCATCAGTAAAAAGAAGAGTGGATGAAGCATACTCCTTAGCAAAGAAAACTTTCCCAAACTCAGAAGCAAAC CCTCTAAATGCCTATTATTTGAAATGTCTTGAAAACCTCGTGCAGCTCCTTAATTCTTCCTGAGTGCCATGGGATGCTACACCTTGAAGC TGACAGTCATCAACAGGGGAGCTAAAGTTGAAGCCAGCTGTGTGTAGCAGCTGTTACCTGAAGACGTGCTACCTCTCTACAAAGTGTTGA TCCCCTTCTTTCCCATGAGAGAGAGAACTGGTGATACTCCAACACCGTCCAGTTGTGGCAGCTCTCCAGAAGTAATAGCAGCTGACAACT TTCTGTGCCTTTTCCTTTCTGTTGAAAAGGCATAGAAAGTTCTGGGAACATAAACATTTTTACCCTTTTCTATGCCATTTATTTTGTAAA >6354_6354_3_ARHGEF7-RTTN_ARHGEF7_chr13_111806338_ENST00000317133_RTTN_chr18_67817969_ENST00000454359_length(amino acids)=1332AA_BP= MVQPCLTLLRKVLCGDPVMRVSLSQQSSLLTVLFRVSLIFHEDCSVVTEVGALFCLLLFDEVSRMDMWSVNPSNKPSLPSVFSLPVSVFR RYHLPVHVIGHHAVSPYSIVLPLSADCLALKPVSDMLRIAWNLSWYHGSDNLLKQMNSETKTQEILDALKLSTEDILTLKITHMASGLQD CLHSIVQAATHREVRAAVTRMSFYLLNDRLSLKGCPGPCGVTLKSLAWHTALNRFLQVLPACTEDEKLLIDIIHFLNKLIKEQRKNSSLE LLNWILELLLRHSANPLLDLLVLTESQAREETDDIRTAVRQQLQKELIALFDTLLLNFMEVTDRKCSELLYVFQTQLALKLLQCLKVTDA PHFYGLPSLERTLRGMANLTAFPGWSSHSPLTKPLDICVKYLSGLLEVITSFYVERGGNAMSFMGKGVTKSTILCLLHLSHEMMAQAGSL EWMSLWFLPLGSHSEEHIPTQQGLAWLIPLWVDRDPEVRFTSLGLGSALTTLETGCVALANSCQNISGGLWGTVVNILLDQSECSMVRRE AAFILQNLLVIPMPTEIIKDYTWQGPCVHDEDSGLSLIGKPALQALLYHCHFYEHLNQMVKHCYLGRCMFDLNFSAFDRNSESNDLNGLD DSFKFWRAPSRTSQDRDPSSLSTSETTVAPSLGSTEFQPLVQSTTLLPEASHDQFVAQGHQESTSPRPPHDSSLSAPLPKLCVFVTPSLL SAMCSLLDNLLTIAPRDTAKAFRQAHLIELLCSIADATLIQTCVQELRALLPSSPPAEHTQAQVSFLLEYLSSLSRLLQSCLLVEPDLVI QDELVKPLITNIIGILTICTKDVLDKELISAFYHTWTHLFNLLAMLLRKAGAITLPFVTVALAKHWTAAIDMFCTCAGLSATCPALYTAS LQFLSVLLTEEAKGHLQAKSKTHLCCSPTVASLLDDSQENQKSLEQLSDVILQCYEGKSSKDILKRVAANALMSLLAVSRRAQKHALKAN LIDNCMEQMKHINAQLNLDSLRPGKAALKKKEDGVIKELSIAMQLLRNCLYQNEECKEAALEAHLVPVLHSLWPWILMDDSLMQISLQLL CVYTANFPNGCSSLCWSSCGQHPVQATHRGAVSNSLMLCILKLASQMPLENTTVQQMVFMLLSNLALSHDCKGVIQKSNFLQNFLSLALP KGGNKHLSNLTILWLKLLLNISSGEDGQQMILRLDGCLDLLTEMSKYKHKSSPLLPLLIFHNVCFSPANKPKILANEKVITVLAACLESE -------------------------------------------------------------- >6354_6354_4_ARHGEF7-RTTN_ARHGEF7_chr13_111806338_ENST00000370623_RTTN_chr18_67817969_ENST00000255674_length(transcript)=5362nt_BP=252nt ATGAATTCCGCCGAGCAAACCGTTACGTGGCTCATCACTCTGGGGGTGCTGGAGTCGCCCAAAAAAACCATCTCGGACCCGGAGGGCTTT CTGCAGGCGTCGCTGAAGGATGGGGTGGTCCTCTGCAGGCTGCTGGAGCGCCTGCTCCCCGGGACCATCGAGAAAGTCTACCCCGAGCCC CGGAGCGAGAGCGAGTGCCTGAGCAACATCCGCGAGTTCCTGCGCGGCTGCGGGGCTTCCCTGCGGCTGGAGGAATGTTTAGGTGTCCAT AATGTCACTAAACCCGTGTCTTCACTTTGCAATGGAATTCATTTTCTACTTCATCCAAAAGTTCTGTATGAAATCTCTGTATTTGGCATT CAAGAGCCCGAAAGTGAGGTGAACACTGCTGCCAAGGCCATTCTGTTATACCTGCTTCAGGGACGATTGATGATGACAGCATTGACCTGG AACAAGTTTATTGAATCTCTCTGTCCTGTCATCCCAATACTACAGGGCTATGCCGACACAGAAGATCCTCTGGGTAACTGCATTCTCCTT CTAAGCAAAGCAAGTTCTGACACAGAAGAGATGCTTCCGTGTACTACCCGATTAAAGTCCATGCTGCGACTTTTGCTAGTGAAAAAGCCA TCGGTCCGTTCGCTAGCATTAAAGCTTTTAGCATTCCATCTTACCAGTGAAGAAGGGGCTGATACAAAGCGTCCTCTAATAGACGCCAGA GTTCTCTCCAGAGTTACTGATTTATTCATTGGGAAGAAACCTATTGAACTCAGACTGGATGACAGAAGAGAGCTGGTTATTAAGTTGGAG ACTGTTGAAAAGGTATATGAAATCTTCACCTCAGATGATGTTGATCTCGTTTTGAGAAAGTCAGCTGCTGAACAGTTAGCTGTGATTATG CAAGATATTAAAATGCATGCTGTGGTGAAAAAGTTATGCTTAATTGACAAAATAATTGAGTATTTAAATGAATGTGTGAGTCAAGATGGC AAGGTTGTAGAATGTTTGGTACAACCATGCCTCACACTCTTGAGGAAGGTTTTATGTGGTGATCCAGTCATGCGTGTTTCGCTCTCGCAA CAGTCTTCTCTTTTGACCGTGTTATTCAGAGTTTCCTTAATATTTCATGAAGATTGTAGTGTCGTGACTGAAGTTGGAGCACTATTTTGT CTTCTATTATTTGATGAAGTATCGAGAATGGATATGTGGTCTGTTAATCCTTCCAATAAACCTTCTTTGCCATCGGTCTTCAGTTTGCCT GTTTCCGTTTTTAGAAGGTACCATCTACCTGTTCATGTAATTGGACACCATGCTGTGAGTCCTTACTCCATAGTTTTGCCCTTATCTGCT GATTGTTTGGCCTTGAAGCCGGTGTCAGATATGCTGAGAATAGCTTGGAACCTGTCATGGTATCATGGGAGTGATAATCTGTTGAAGCAA ATGAACTCTGAAACTAAAACGCAAGAAATTTTAGATGCATTGAAGTTATCTACAGAGGACATCCTCACTCTGAAGATAACACACATGGCT AGTGGGCTGCAGGACTGCCTCCATTCCATTGTTCAGGCTGCAACCCACAGGGAAGTTAGGGCTGCTGTCACCAGGATGAGTTTTTATCTT CTGAATGACAGATTGTCTTTAAAGGGTTGCCCTGGTCCATGTGGGGTTACCTTGAAGTCCTTGGCTTGGCACACCGCACTAAACAGGTTT TTACAGGTGCTTCCTGCTTGCACTGAAGATGAGAAACTGCTAATAGATATCATACATTTTTTAAATAAATTAATAAAGGAACAAAGAAAA AATTCTTCACTAGAACTTCTAAACTGGATTCTCGAATTACTTCTTAGACATAGTGCAAACCCACTGTTAGACCTCTTGGTTCTGACAGAG TCACAGGCACGAGAAGAAACAGATGATATCCGGACTGCTGTCAGGCAACAACTTCAGAAAGAACTGATTGCTCTTTTTGATACCTTGCTG CTCAATTTCATGGAAGTTACTGACAGGAAATGCTCGGAACTTCTTTACGTTTTTCAAACGCAGCTGGCTCTGAAACTGCTCCAGTGTCTG AAAGTGACGGATGCGCCTCATTTCTATGGCCTGCCGTCCCTTGAGCGGACCTTACGAGGGATGGCTAACCTCACTGCGTTTCCGGGATGG AGCTCACACTCTCCTCTCACAAAGCCTCTAGATATCTGTGTGAAGTACTTGTCAGGTCTCCTTGAGGTCATTACTTCTTTTTATGTGGAG CGTGGAGGAAATGCTATGTCCTTCATGGGAAAAGGTGTTACAAAGAGCACAATTCTTTGCTTGCTTCACTTATCCCATGAGATGATGGCC CAGGCTGGGAGCTTGGAGTGGATGTCACTTTGGTTCTTGCCTTTGGGTAGTCATAGTGAAGAACATATTCCTACTCAACAAGGATTGGCT TGGTTGATTCCATTATGGGTTGATCGGGACCCAGAGGTGAGATTCACTTCACTGGGATTAGGATCAGCACTGACCACCCTTGAAACGGGC TGTGTGGCCTTAGCAAACAGTTGTCAGAACATTTCCGGTGGGCTCTGGGGAACTGTGGTGAACATTCTTCTGGACCAGTCAGAATGTAGT ATGGTGCGCCGGGAGGCGGCATTTATTCTTCAGAATCTCCTTGTAATTCCAATGCCTACAGAAATTATAAAGGATTATACTTGGCAGGGT CCCTGTGTTCATGATGAGGACTCTGGCCTATCGCTCATTGGAAAACCTGCCCTTCAGGCTCTTTTATATCACTGCCATTTTTATGAACAT TTGAATCAGATGGTAAAGCATTGTTACCTAGGACGGTGTATGTTTGATTTGAATTTTTCTGCTTTTGATAGAAATTCAGAAAGCAATGAT TTAAATGGTTTAGATGACTCATTCAAGTTTTGGAGGGCTCCATCTAGGACAAGTCAGGATCGAGATCCAAGTTCTCTCTCCACCTCAGAA ACAACGGTGGCACCTTCATTGGGGAGTACTGAATTTCAGCCACTTGTGCAGTCAACAACACTTCTACCTGAAGCCTCCCATGACCAGTTT GTGGCTCAAGGTCACCAGGAAAGTACATCACCACGGCCACCTCATGATTCATCTCTTTCTGCTCCCCTGCCCAAACTGTGTGTTTTTGTT ACTCCATCTCTTCTTTCAGCAATGTGCAGCCTCTTGGACAACCTCTTGACGATTGCTCCCAGAGACACTGCAAAGGCTTTTCGACAAGCT CATCTCATAGAACTTCTCTGTAGCATTGCAGATGCTACCCTCATACAGACATGTGTCCAGGAACTCAGAGCCCTGCTGCCTTCATCACCT CCAGCTGAACACACTCAGGCTCAGGTTTCCTTTCTCCTGGAATACCTATCCTCTTTGTCCAGGCTTCTGCAGTCATGTTTATTGGTGGAG CCTGACCTTGTGATTCAGGATGAGCTTGTGAAACCTCTTATCACCAATATCATTGGAATTCTCACCATATGTACCAAAGATGTATTAGAT AAAGAGTTAATATCAGCTTTTTATCACACATGGACACATTTATTTAATCTTCTGGCCATGCTCCTGAGGAAAGCTGGTGCCATCACACTC CCGTTTGTTACCGTGGCCCTGGCCAAGCACTGGACAGCGGCGATTGATATGTTCTGCACATGTGCAGGCTTGTCTGCCACGTGTCCTGCC CTGTATACTGCCAGCTTGCAATTCCTTTCTGTTCTCTTGACCGAAGAAGCAAAAGGGCATCTCCAGGCTAAGAGCAAAACACATTTATGC TGTAGTCCAACAGTGGCTTCACTTCTTGATGACTCTCAGGAAAATCAGAAATCTCTAGAACAACTTAGTGATGTAATCCTTCAGTGCTAT GAAGGGAAATCCTCCAAAGATATCCTGAAAAGAGTAGCTGCAAATGCATTGATGTCACTGCTGGCTGTCAGTAGAAGAGCACAGAAACAT GCTTTGAAAGCCAATCTTATAGACAATTGCATGGAGCAGATGAAACACATAAATGCACAACTGAACCTAGATTCTCTGAGGCCTGGGAAA GCAGCATTGAAAAAAAAGGAGGATGGTGTTATTAAAGAGTTAAGCATTGCCATGCAGCTCCTAAGAAACTGTCTTTATCAAAATGAGGAA TGTAAAGAAGCAGCTCTTGAAGCTCACCTTGTCCCTGTCTTGCACTCTCTCTGGCCTTGGATTTTGATGGATGATTCATTGATGCAAATT TCTCTGCAGCTCCTTTGTGTCTATACTGCAAATTTTCCAAATGGTTGCAGTTCTCTTTGTTGGTCAAGTTGTGGACAACACCCTGTTCAA GCTACACATAGAGGAGCCGTGAGCAACTCTCTGATGCTGTGTATCCTAAAGTTGGCTTCCCAGATGCCACTGGAGAACACCACGGTTCAG CAGATGGTTTTTATGCTTCTTTCAAACCTGGCCTTGTCGCATGACTGTAAAGGAGTAATTCAGAAGAGTAACTTCTTACAGAACTTCCTC TCTCTAGCATTGCCAAAAGGAGGAAATAAACATCTAAGTAATCTGACTATTCTTTGGTTGAAGTTACTCCTGAATATATCATCTGGAGAA GATGGGCAACAAATGATTCTGAGGCTTGATGGCTGTCTAGACTTACTAACAGAGATGAGCAAATACAAGCACAAGAGCAGCCCTTTATTG CCTCTTCTTATCTTTCATAATGTTTGCTTCAGTCCTGCAAATAAACCCAAGATCCTGGCTAATGAAAAAGTCATTACTGTGCTTGCTGCC TGTCTGGAAAGTGAGAATCAAAATGCTCAGAGGATTGGAGCAGCTGCCCTTTGGGCTCTGATTTACAATTATCAGAAGGCAAAAACAGCT TTGAAAAGCCCATCAGTAAAAAGAAGAGTGGATGAAGCATACTCCTTAGCAAAGAAAACTTTCCCAAACTCAGAAGCAAACCCTCTAAAT GCCTATTATTTGAAATGTCTTGAAAACCTCGTGCAGCTCCTTAATTCTTCCTGAGTGCCATGGGATGCTACACCTTGAAGCTGACAGTCA TCAACAGGGGAGCTAAAGTTGAAGCCAGCTGTGTGTAGCAGCTGTTACCTGAAGACGTGCTACCTCTCTACAAAGTGTTGATCCCCTTCT TTCCCATGAGAGAGAGAACTGGTGATACTCCAACACCGTCCAGTTGTGGCAGCTCTCCAGAAGTAATAGCAGCTGACAACTTTCTGTGCC TTTTCCTTTCTGTTGAAAAGGCATAGAAAGTTCTGGGAACATAAACATTTTTACCCTTTTCTATGCCATTTATTTTGTAAAAATCCTATT >6354_6354_4_ARHGEF7-RTTN_ARHGEF7_chr13_111806338_ENST00000370623_RTTN_chr18_67817969_ENST00000255674_length(amino acids)=1667AA_BP=82 MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEPRSESECLSNIREFLRGCGASLRLEECLGVH NVTKPVSSLCNGIHFLLHPKVLYEISVFGIQEPESEVNTAAKAILLYLLQGRLMMTALTWNKFIESLCPVIPILQGYADTEDPLGNCILL LSKASSDTEEMLPCTTRLKSMLRLLLVKKPSVRSLALKLLAFHLTSEEGADTKRPLIDARVLSRVTDLFIGKKPIELRLDDRRELVIKLE TVEKVYEIFTSDDVDLVLRKSAAEQLAVIMQDIKMHAVVKKLCLIDKIIEYLNECVSQDGKVVECLVQPCLTLLRKVLCGDPVMRVSLSQ QSSLLTVLFRVSLIFHEDCSVVTEVGALFCLLLFDEVSRMDMWSVNPSNKPSLPSVFSLPVSVFRRYHLPVHVIGHHAVSPYSIVLPLSA DCLALKPVSDMLRIAWNLSWYHGSDNLLKQMNSETKTQEILDALKLSTEDILTLKITHMASGLQDCLHSIVQAATHREVRAAVTRMSFYL LNDRLSLKGCPGPCGVTLKSLAWHTALNRFLQVLPACTEDEKLLIDIIHFLNKLIKEQRKNSSLELLNWILELLLRHSANPLLDLLVLTE SQAREETDDIRTAVRQQLQKELIALFDTLLLNFMEVTDRKCSELLYVFQTQLALKLLQCLKVTDAPHFYGLPSLERTLRGMANLTAFPGW SSHSPLTKPLDICVKYLSGLLEVITSFYVERGGNAMSFMGKGVTKSTILCLLHLSHEMMAQAGSLEWMSLWFLPLGSHSEEHIPTQQGLA WLIPLWVDRDPEVRFTSLGLGSALTTLETGCVALANSCQNISGGLWGTVVNILLDQSECSMVRREAAFILQNLLVIPMPTEIIKDYTWQG PCVHDEDSGLSLIGKPALQALLYHCHFYEHLNQMVKHCYLGRCMFDLNFSAFDRNSESNDLNGLDDSFKFWRAPSRTSQDRDPSSLSTSE TTVAPSLGSTEFQPLVQSTTLLPEASHDQFVAQGHQESTSPRPPHDSSLSAPLPKLCVFVTPSLLSAMCSLLDNLLTIAPRDTAKAFRQA HLIELLCSIADATLIQTCVQELRALLPSSPPAEHTQAQVSFLLEYLSSLSRLLQSCLLVEPDLVIQDELVKPLITNIIGILTICTKDVLD KELISAFYHTWTHLFNLLAMLLRKAGAITLPFVTVALAKHWTAAIDMFCTCAGLSATCPALYTASLQFLSVLLTEEAKGHLQAKSKTHLC CSPTVASLLDDSQENQKSLEQLSDVILQCYEGKSSKDILKRVAANALMSLLAVSRRAQKHALKANLIDNCMEQMKHINAQLNLDSLRPGK AALKKKEDGVIKELSIAMQLLRNCLYQNEECKEAALEAHLVPVLHSLWPWILMDDSLMQISLQLLCVYTANFPNGCSSLCWSSCGQHPVQ ATHRGAVSNSLMLCILKLASQMPLENTTVQQMVFMLLSNLALSHDCKGVIQKSNFLQNFLSLALPKGGNKHLSNLTILWLKLLLNISSGE DGQQMILRLDGCLDLLTEMSKYKHKSSPLLPLLIFHNVCFSPANKPKILANEKVITVLAACLESENQNAQRIGAAALWALIYNYQKAKTA -------------------------------------------------------------- >6354_6354_5_ARHGEF7-RTTN_ARHGEF7_chr13_111806338_ENST00000370623_RTTN_chr18_67817969_ENST00000437017_length(transcript)=3105nt_BP=252nt ATGAATTCCGCCGAGCAAACCGTTACGTGGCTCATCACTCTGGGGGTGCTGGAGTCGCCCAAAAAAACCATCTCGGACCCGGAGGGCTTT CTGCAGGCGTCGCTGAAGGATGGGGTGGTCCTCTGCAGGCTGCTGGAGCGCCTGCTCCCCGGGACCATCGAGAAAGTCTACCCCGAGCCC CGGAGCGAGAGCGAGTGCCTGAGCAACATCCGCGAGTTCCTGCGCGGCTGCGGGGCTTCCCTGCGGCTGGAGGAATGTTTAGGTGTCCAT AATGTCACTAAACCCGTGTCTTCACTTTGCAATGGAATTCATTTTCTACTTCATCCAAAAGTTCTGTATGAAATCTCTGTATTTGGCATT CAAGAGCCCGAAAGTGAGGTGAACACTGCTGCCAAGGCCATTCTGTTATACCTGCTTCAGGGACGATTGATGATGACAGCATTGACCTGG AACAAGTTTATTGAATCTCTCTGTCCTGTCATCCCAATACTACAGGGCTATGCCGACACAGAAGATCCTCTGGGTAACTGCATTCTCCTT CTAAGCAAAGCAAGTTCTGACACAGAAGAGATGCTTCCGTGTACTACCCGATTAAAGTCCATGCTGCGACTTTTGCTAGTGAAAAAGCCA TCGGTCCGTTCGCTAGCATTAAAGCTTTTAGCATTCCATCTTACCAGTGAAGAAGGGGCTGATACAAAGCGTCCTCTAATAGACGCCAGA GTTCTCTCCAGAGTTACTGATTTATTCATTGGGAAGAAACCTATTGAACTCAGACTGGATGACAGAAGAGAGCTGGTTATTAAGTTGGAG ACTGTTGAAAAGGTATATGAAATCTTCACCTCAGATGATGTTGATCTCGTTTTGAGAAAGTCAGCTGCTGAACAGTTAGCTGTGATTATG CAAGATATTAAAATGCATGCTGTGGTGAAAAAGTTATGCTTAATTGACAAAATAATTGAGTATTTAAATGAATGTGTGAGTCAAGATGGC AAGGTTGTAGAATGTTTGGTACAACCATGCCTCACACTCTTGAGGAAGGTTTTATGTGGTGATCCAGTCATGCGTGTTTCGCTCTCGCAA CAGTCTTCTCTTTTGACCGTGTTATTCAGAGTTTCCTTAATATTTCATGAAGATTGTAGTGTCGTGACTGAAGTTGGAGCACTATTTTGT CTTCTATTATTTGATGAAGTATCGAGAATGGATATGTGGTCTGTTAATCCTTCCAATAAACCTTCTTTGCCATCGGTCTTCAGTTTGCCT GTTTCCGTTTTTAGAAGGTACCATCTACCTGTTCATGTAATTGGACACCATGCTGTGAGTCCTTACTCCATAGTTTTGCCCTTATCTGCT GATTGTTTGGCCTTGAAGCCGGTGTCAGATATGCTGAGAATAGCTTGGAACCTGTCATGGTATCATGGGAGTGATAATCTGTTGAAGCAA ATGAACTCTGAAACTAAAACGCAAGAAATTTTAGATGCATTGAAGTTATCTACAGAGGACATCCTCACTCTGAAGATAACACACATGGCT AGTGGGCTGCAGGACTGCCTCCATTCCATTGTTCAGGCTGCAACCCACAGGGAAGTTAGGGCTGCTGTCACCAGGATGAGTTTTTATCTT CTGAATGACAGATTGTCTTTAAAGGGTTGCCCTGGTCCATGTGGGGTTACCTTGAAGTCCTTGGCTTGGCACACCGCACTAAACAGGTTT TTACAGGTGCTTCCTGCTTGCACTGAAGATGAGAAACTGCTAATAGATATCATACATTTTTTAAATAAATTAATAAAGGAACAAAGAAAA AATTCTTCACTAGAACTTCTAAACTGGATTCTCGAATTACTTCTTAGACATAGTGCAAACCCACTGTTAGACCTCTTGGTTCTGACAGAG TCACAGGCACGAGAAGAAACAGATGATATCCGGACTGCTGTCAGGCAACAACTTCAGAAAGAACTGATTGCTCTTTTTGATACCTTGCTG CTCAATTTCATGGAAGTTACTGACAGGAAATGCTCGGAACTTCTTTACGTTTTTCAAACGCAGCTGGCTCTGAAACTGCTCCAGTGTCTG AAAGTGACGGATGCGCCTCATTTCTATGGCCTGCCGTCCCTTGAGCGGACCTTACGAGGGATGGCTAACCTCACTGCGTTTCCGGGATGG AGCTCACACTCTCCTCTCACAAAGCCTCTAGATATCTGTGTGAAGTACTTGTCAGGTCTCCTTGAGGTCATTACTTCTTTTTATGTGGAG CGTGGAGGAAATGCTATGTCCTTCATGGGAAAAGGTGTTACAAAGAGCACAATTCTTTGCTTGCTTCACTTATCCCATGAGATGATGGCC CAGGCTGGGAGCTTGGAGTGGATGTCACTTTGGTTCTTGCCTTTGGGTAGTCATAGTGAAGAACATATTCCTACTCAACAAGGATTGGCT TGGTTGATTCCATTATGGGTTGATCGGGACCCAGAGGTGAGATTCACTTCACTGGGATTAGGATCAGCACTGACCACCCTTGAAACGGGC TGTGTGGCCTTAGCAAACAGTTGTCAGAACATTTCCGGTGGGCTCTGGGGAACTGTGGTGAACATTCTTCTGGACCAGTCAGAATGTAGT ATGGTGCGCCGGGAGGCGGCATTTATTCTTCAGAATCTCCTTGTAATTCCAATGCCTACAGAAATTATAAAGGATTATACTTGGCAGGGT CCCTGTGTTCATGATGAGGACTCTGGCCTATCGCTCATTGGAAAACCTGCCCTTCAGGCTCTTTTATATCACTGCCATTTTTATGAACAT TTGAATCAGATGGTAAAGCATTGTTACCTAGGACGGTGTATGTTTGATTTGAATTTTTCTGCTTTTGATAGAAATTCAGAAAGCAATGAT TTAAATGGTTTAGATGACTCATTCAAGTTTTGGAGGGCTCCATCTAGGACAAGTCAGGATCGAGATCCAAGTTCTCTCTCCACCTCAGAA ACAACGGTGGCACCTTCATTGGGGAGTACTGAATTTCAGCCACTTGTGCAGTCAACAACACTTCTACCTGAAGCCTCCCATGACCAGTTT >6354_6354_5_ARHGEF7-RTTN_ARHGEF7_chr13_111806338_ENST00000370623_RTTN_chr18_67817969_ENST00000437017_length(amino acids)=1034AA_BP=82 MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEPRSESECLSNIREFLRGCGASLRLEECLGVH NVTKPVSSLCNGIHFLLHPKVLYEISVFGIQEPESEVNTAAKAILLYLLQGRLMMTALTWNKFIESLCPVIPILQGYADTEDPLGNCILL LSKASSDTEEMLPCTTRLKSMLRLLLVKKPSVRSLALKLLAFHLTSEEGADTKRPLIDARVLSRVTDLFIGKKPIELRLDDRRELVIKLE TVEKVYEIFTSDDVDLVLRKSAAEQLAVIMQDIKMHAVVKKLCLIDKIIEYLNECVSQDGKVVECLVQPCLTLLRKVLCGDPVMRVSLSQ QSSLLTVLFRVSLIFHEDCSVVTEVGALFCLLLFDEVSRMDMWSVNPSNKPSLPSVFSLPVSVFRRYHLPVHVIGHHAVSPYSIVLPLSA DCLALKPVSDMLRIAWNLSWYHGSDNLLKQMNSETKTQEILDALKLSTEDILTLKITHMASGLQDCLHSIVQAATHREVRAAVTRMSFYL LNDRLSLKGCPGPCGVTLKSLAWHTALNRFLQVLPACTEDEKLLIDIIHFLNKLIKEQRKNSSLELLNWILELLLRHSANPLLDLLVLTE SQAREETDDIRTAVRQQLQKELIALFDTLLLNFMEVTDRKCSELLYVFQTQLALKLLQCLKVTDAPHFYGLPSLERTLRGMANLTAFPGW SSHSPLTKPLDICVKYLSGLLEVITSFYVERGGNAMSFMGKGVTKSTILCLLHLSHEMMAQAGSLEWMSLWFLPLGSHSEEHIPTQQGLA WLIPLWVDRDPEVRFTSLGLGSALTTLETGCVALANSCQNISGGLWGTVVNILLDQSECSMVRREAAFILQNLLVIPMPTEIIKDYTWQG PCVHDEDSGLSLIGKPALQALLYHCHFYEHLNQMVKHCYLGRCMFDLNFSAFDRNSESNDLNGLDDSFKFWRAPSRTSQDRDPSSLSTSE -------------------------------------------------------------- >6354_6354_6_ARHGEF7-RTTN_ARHGEF7_chr13_111806338_ENST00000370623_RTTN_chr18_67817969_ENST00000454359_length(transcript)=5257nt_BP=252nt ATGAATTCCGCCGAGCAAACCGTTACGTGGCTCATCACTCTGGGGGTGCTGGAGTCGCCCAAAAAAACCATCTCGGACCCGGAGGGCTTT CTGCAGGCGTCGCTGAAGGATGGGGTGGTCCTCTGCAGGCTGCTGGAGCGCCTGCTCCCCGGGACCATCGAGAAAGTCTACCCCGAGCCC CGGAGCGAGAGCGAGTGCCTGAGCAACATCCGCGAGTTCCTGCGCGGCTGCGGGGCTTCCCTGCGGCTGGAGGAATGTTTAGGTGTCCAT AATGTCACTAAACCCGTGTCTTCACTTTGCAATGGAATTCATTTTCTACTTCATCCAAAAGTTCTGTATGAAATCTCTGTATTTGGCATT CAAGAGCCCGAAAGTGAGGTGAACACTGCTGCCAAGGCCATTCTGTTATACCTGCTTCAGGGACGATTGATGATGACAGCATTGACCTGG AACAAGTTTATTGAATCTCTCTGTCCTGTCATCCCAATACTACAGGGCTATGCCGACACAGAAGATCCTCTGGGTAACTGCATTCTCCTT CTAAGCAAAGCAAGTTCTGACACAGAAGAGATGCTTCCGTGTACTACCCGATTAAAGTCCATGCTGCGACTTTTGCTAGTGAAAAAGCCA TCGGTCCGTTCGCTAGCATTAAAGCTTTTAGCATTCCATCTTACCAGTGAAGAAGGGGCTGATACAAAGCGTCCTCTAATAGACGCCAGA GTTCTCTCCAGAGTTACTGATTTATTCATTGGGAAGAAACCTATTGAACTCAGACTGGATGACAGAAGAGAGCTGGTTATTAAGTTGGAG ACTGTTGAAAAGGTATATGAAATCTTCACCTCAGATGATGTTGATCTCGTTTTGAGAAAGTCAGCTGCTGAACAGTTAGCTGTGATTATG CAAGGTTGTAGAATGTTTGGTACAACCATGCCTCACACTCTTGAGGAAGGTTTTATGTGGTGATCCAGTCATGCGTGTTTCGCTCTCGCA ACAGTCTTCTCTTTTGACCGTGTTATTCAGAGTTTCCTTAATATTTCATGAAGATTGTAGTGTCGTGACTGAAGTTGGAGCACTATTTTG TCTTCTATTATTTGATGAAGTATCGAGAATGGATATGTGGTCTGTTAATCCTTCCAATAAACCTTCTTTGCCATCGGTCTTCAGTTTGCC TGTTTCCGTTTTTAGAAGGTACCATCTACCTGTTCATGTAATTGGACACCATGCTGTGAGTCCTTACTCCATAGTTTTGCCCTTATCTGC TGATTGTTTGGCCTTGAAGCCGGTGTCAGATATGCTGAGAATAGCTTGGAACCTGTCATGGTATCATGGGAGTGATAATCTGTTGAAGCA AATGAACTCTGAAACTAAAACGCAAGAAATTTTAGATGCATTGAAGTTATCTACAGAGGACATCCTCACTCTGAAGATAACACACATGGC TAGTGGGCTGCAGGACTGCCTCCATTCCATTGTTCAGGCTGCAACCCACAGGGAAGTTAGGGCTGCTGTCACCAGGATGAGTTTTTATCT TCTGAATGACAGATTGTCTTTAAAGGGTTGCCCTGGTCCATGTGGGGTTACCTTGAAGTCCTTGGCTTGGCACACCGCACTAAACAGGTT TTTACAGGTGCTTCCTGCTTGCACTGAAGATGAGAAACTGCTAATAGATATCATACATTTTTTAAATAAATTAATAAAGGAACAAAGAAA AAATTCTTCACTAGAACTTCTAAACTGGATTCTCGAATTACTTCTTAGACATAGTGCAAACCCACTGTTAGACCTCTTGGTTCTGACAGA GTCACAGGCACGAGAAGAAACAGATGATATCCGGACTGCTGTCAGGCAACAACTTCAGAAAGAACTGATTGCTCTTTTTGATACCTTGCT GCTCAATTTCATGGAAGTTACTGACAGGAAATGCTCGGAACTTCTTTACGTTTTTCAAACGCAGCTGGCTCTGAAACTGCTCCAGTGTCT GAAAGTGACGGATGCGCCTCATTTCTATGGCCTGCCGTCCCTTGAGCGGACCTTACGAGGGATGGCTAACCTCACTGCGTTTCCGGGATG GAGCTCACACTCTCCTCTCACAAAGCCTCTAGATATCTGTGTGAAGTACTTGTCAGGTCTCCTTGAGGTCATTACTTCTTTTTATGTGGA GCGTGGAGGAAATGCTATGTCCTTCATGGGAAAAGGTGTTACAAAGAGCACAATTCTTTGCTTGCTTCACTTATCCCATGAGATGATGGC CCAGGCTGGGAGCTTGGAGTGGATGTCACTTTGGTTCTTGCCTTTGGGTAGTCATAGTGAAGAACATATTCCTACTCAACAAGGATTGGC TTGGTTGATTCCATTATGGGTTGATCGGGACCCAGAGGTGAGATTCACTTCACTGGGATTAGGATCAGCACTGACCACCCTTGAAACGGG CTGTGTGGCCTTAGCAAACAGTTGTCAGAACATTTCCGGTGGGCTCTGGGGAACTGTGGTGAACATTCTTCTGGACCAGTCAGAATGTAG TATGGTGCGCCGGGAGGCGGCATTTATTCTTCAGAATCTCCTTGTAATTCCAATGCCTACAGAAATTATAAAGGATTATACTTGGCAGGG TCCCTGTGTTCATGATGAGGACTCTGGCCTATCGCTCATTGGAAAACCTGCCCTTCAGGCTCTTTTATATCACTGCCATTTTTATGAACA TTTGAATCAGATGGTAAAGCATTGTTACCTAGGACGGTGTATGTTTGATTTGAATTTTTCTGCTTTTGATAGAAATTCAGAAAGCAATGA TTTAAATGGTTTAGATGACTCATTCAAGTTTTGGAGGGCTCCATCTAGGACAAGTCAGGATCGAGATCCAAGTTCTCTCTCCACCTCAGA AACAACGGTGGCACCTTCATTGGGGAGTACTGAATTTCAGCCACTTGTGCAGTCAACAACACTTCTACCTGAAGCCTCCCATGACCAGTT TGTGGCTCAAGGTCACCAGGAAAGTACATCACCACGGCCACCTCATGATTCATCTCTTTCTGCTCCCCTGCCCAAACTGTGTGTTTTTGT TACTCCATCTCTTCTTTCAGCAATGTGCAGCCTCTTGGACAACCTCTTGACGATTGCTCCCAGAGACACTGCAAAGGCTTTTCGACAAGC TCATCTCATAGAACTTCTCTGTAGCATTGCAGATGCTACCCTCATACAGACATGTGTCCAGGAACTCAGAGCCCTGCTGCCTTCATCACC TCCAGCTGAACACACTCAGGCTCAGGTTTCCTTTCTCCTGGAATACCTATCCTCTTTGTCCAGGCTTCTGCAGTCATGTTTATTGGTGGA GCCTGACCTTGTGATTCAGGATGAGCTTGTGAAACCTCTTATCACCAATATCATTGGAATTCTCACCATATGTACCAAAGATGTATTAGA TAAAGAGTTAATATCAGCTTTTTATCACACATGGACACATTTATTTAATCTTCTGGCCATGCTCCTGAGGAAAGCTGGTGCCATCACACT CCCGTTTGTTACCGTGGCCCTGGCCAAGCACTGGACAGCGGCGATTGATATGTTCTGCACATGTGCAGGCTTGTCTGCCACGTGTCCTGC CCTGTATACTGCCAGCTTGCAATTCCTTTCTGTTCTCTTGACCGAAGAAGCAAAAGGGCATCTCCAGGCTAAGAGCAAAACACATTTATG CTGTAGTCCAACAGTGGCTTCACTTCTTGATGACTCTCAGGAAAATCAGAAATCTCTAGAACAACTTAGTGATGTAATCCTTCAGTGCTA TGAAGGGAAATCCTCCAAAGATATCCTGAAAAGAGTAGCTGCAAATGCATTGATGTCACTGCTGGCTGTCAGTAGAAGAGCACAGAAACA TGCTTTGAAAGCCAATCTTATAGACAATTGCATGGAGCAGATGAAACACATAAATGCACAACTGAACCTAGATTCTCTGAGGCCTGGGAA AGCAGCATTGAAAAAAAAGGAGGATGGTGTTATTAAAGAGTTAAGCATTGCCATGCAGCTCCTAAGAAACTGTCTTTATCAAAATGAGGA ATGTAAAGAAGCAGCTCTTGAAGCTCACCTTGTCCCTGTCTTGCACTCTCTCTGGCCTTGGATTTTGATGGATGATTCATTGATGCAAAT TTCTCTGCAGCTCCTTTGTGTCTATACTGCAAATTTTCCAAATGGTTGCAGTTCTCTTTGTTGGTCAAGTTGTGGACAACACCCTGTTCA AGCTACACATAGAGGAGCCGTGAGCAACTCTCTGATGCTGTGTATCCTAAAGTTGGCTTCCCAGATGCCACTGGAGAACACCACGGTTCA GCAGATGGTTTTTATGCTTCTTTCAAACCTGGCCTTGTCGCATGACTGTAAAGGAGTAATTCAGAAGAGTAACTTCTTACAGAACTTCCT CTCTCTAGCATTGCCAAAAGGAGGAAATAAACATCTAAGTAATCTGACTATTCTTTGGTTGAAGTTACTCCTGAATATATCATCTGGAGA AGATGGGCAACAAATGATTCTGAGGCTTGATGGCTGTCTAGACTTACTAACAGAGATGAGCAAATACAAGCACAAGAGCAGCCCTTTATT GCCTCTTCTTATCTTTCATAATGTTTGCTTCAGTCCTGCAAATAAACCCAAGATCCTGGCTAATGAAAAAGTCATTACTGTGCTTGCTGC CTGTCTGGAAAGTGAGAATCAAAATGCTCAGAGGATTGGAGCAGCTGCCCTTTGGGCTCTGATTTACAATTATCAGAAGGCAAAAACAGC TTTGAAAAGCCCATCAGTAAAAAGAAGAGTGGATGAAGCATACTCCTTAGCAAAGAAAACTTTCCCAAACTCAGAAGCAAACCCTCTAAA TGCCTATTATTTGAAATGTCTTGAAAACCTCGTGCAGCTCCTTAATTCTTCCTGAGTGCCATGGGATGCTACACCTTGAAGCTGACAGTC ATCAACAGGGGAGCTAAAGTTGAAGCCAGCTGTGTGTAGCAGCTGTTACCTGAAGACGTGCTACCTCTCTACAAAGTGTTGATCCCCTTC TTTCCCATGAGAGAGAGAACTGGTGATACTCCAACACCGTCCAGTTGTGGCAGCTCTCCAGAAGTAATAGCAGCTGACAACTTTCTGTGC CTTTTCCTTTCTGTTGAAAAGGCATAGAAAGTTCTGGGAACATAAACATTTTTACCCTTTTCTATGCCATTTATTTTGTAAAAATCCTAT >6354_6354_6_ARHGEF7-RTTN_ARHGEF7_chr13_111806338_ENST00000370623_RTTN_chr18_67817969_ENST00000454359_length(amino acids)=1332AA_BP= MVQPCLTLLRKVLCGDPVMRVSLSQQSSLLTVLFRVSLIFHEDCSVVTEVGALFCLLLFDEVSRMDMWSVNPSNKPSLPSVFSLPVSVFR RYHLPVHVIGHHAVSPYSIVLPLSADCLALKPVSDMLRIAWNLSWYHGSDNLLKQMNSETKTQEILDALKLSTEDILTLKITHMASGLQD CLHSIVQAATHREVRAAVTRMSFYLLNDRLSLKGCPGPCGVTLKSLAWHTALNRFLQVLPACTEDEKLLIDIIHFLNKLIKEQRKNSSLE LLNWILELLLRHSANPLLDLLVLTESQAREETDDIRTAVRQQLQKELIALFDTLLLNFMEVTDRKCSELLYVFQTQLALKLLQCLKVTDA PHFYGLPSLERTLRGMANLTAFPGWSSHSPLTKPLDICVKYLSGLLEVITSFYVERGGNAMSFMGKGVTKSTILCLLHLSHEMMAQAGSL EWMSLWFLPLGSHSEEHIPTQQGLAWLIPLWVDRDPEVRFTSLGLGSALTTLETGCVALANSCQNISGGLWGTVVNILLDQSECSMVRRE AAFILQNLLVIPMPTEIIKDYTWQGPCVHDEDSGLSLIGKPALQALLYHCHFYEHLNQMVKHCYLGRCMFDLNFSAFDRNSESNDLNGLD DSFKFWRAPSRTSQDRDPSSLSTSETTVAPSLGSTEFQPLVQSTTLLPEASHDQFVAQGHQESTSPRPPHDSSLSAPLPKLCVFVTPSLL SAMCSLLDNLLTIAPRDTAKAFRQAHLIELLCSIADATLIQTCVQELRALLPSSPPAEHTQAQVSFLLEYLSSLSRLLQSCLLVEPDLVI QDELVKPLITNIIGILTICTKDVLDKELISAFYHTWTHLFNLLAMLLRKAGAITLPFVTVALAKHWTAAIDMFCTCAGLSATCPALYTAS LQFLSVLLTEEAKGHLQAKSKTHLCCSPTVASLLDDSQENQKSLEQLSDVILQCYEGKSSKDILKRVAANALMSLLAVSRRAQKHALKAN LIDNCMEQMKHINAQLNLDSLRPGKAALKKKEDGVIKELSIAMQLLRNCLYQNEECKEAALEAHLVPVLHSLWPWILMDDSLMQISLQLL CVYTANFPNGCSSLCWSSCGQHPVQATHRGAVSNSLMLCILKLASQMPLENTTVQQMVFMLLSNLALSHDCKGVIQKSNFLQNFLSLALP KGGNKHLSNLTILWLKLLLNISSGEDGQQMILRLDGCLDLLTEMSKYKHKSSPLLPLLIFHNVCFSPANKPKILANEKVITVLAACLESE -------------------------------------------------------------- >6354_6354_7_ARHGEF7-RTTN_ARHGEF7_chr13_111806338_ENST00000375741_RTTN_chr18_67817969_ENST00000255674_length(transcript)=5612nt_BP=502nt GCGGCCGAGGCCGGGGGGCGGCGGCGGGCGCCCGCAGGTTCCCGAGCCGCTCCTGAGAAGGCGCCTGACAGCGGGCCGGGGCGCACGGAG AAGCGGGCCGGGCCGGACCTGCTGGGCCGCGCCGAGCCAATCGCCGGCGCCGGCCGCTCGATGGGCGAGGCGGCGGCGGCGGCGGCGGGG GCCGCGGGCCGGGCCGCCGCTCCGAGGTGAAGGCGCGCGCCCCTCCCCGCCTGCCTCCCGGGCCGCAGCGATGAATTCCGCCGAGCAAAC CGTTACGTGGCTCATCACTCTGGGGGTGCTGGAGTCGCCCAAAAAAACCATCTCGGACCCGGAGGGCTTTCTGCAGGCGTCGCTGAAGGA TGGGGTGGTCCTCTGCAGGCTGCTGGAGCGCCTGCTCCCCGGGACCATCGAGAAAGTCTACCCCGAGCCCCGGAGCGAGAGCGAGTGCCT GAGCAACATCCGCGAGTTCCTGCGCGGCTGCGGGGCTTCCCTGCGGCTGGAGGAATGTTTAGGTGTCCATAATGTCACTAAACCCGTGTC TTCACTTTGCAATGGAATTCATTTTCTACTTCATCCAAAAGTTCTGTATGAAATCTCTGTATTTGGCATTCAAGAGCCCGAAAGTGAGGT GAACACTGCTGCCAAGGCCATTCTGTTATACCTGCTTCAGGGACGATTGATGATGACAGCATTGACCTGGAACAAGTTTATTGAATCTCT CTGTCCTGTCATCCCAATACTACAGGGCTATGCCGACACAGAAGATCCTCTGGGTAACTGCATTCTCCTTCTAAGCAAAGCAAGTTCTGA CACAGAAGAGATGCTTCCGTGTACTACCCGATTAAAGTCCATGCTGCGACTTTTGCTAGTGAAAAAGCCATCGGTCCGTTCGCTAGCATT AAAGCTTTTAGCATTCCATCTTACCAGTGAAGAAGGGGCTGATACAAAGCGTCCTCTAATAGACGCCAGAGTTCTCTCCAGAGTTACTGA TTTATTCATTGGGAAGAAACCTATTGAACTCAGACTGGATGACAGAAGAGAGCTGGTTATTAAGTTGGAGACTGTTGAAAAGGTATATGA AATCTTCACCTCAGATGATGTTGATCTCGTTTTGAGAAAGTCAGCTGCTGAACAGTTAGCTGTGATTATGCAAGATATTAAAATGCATGC TGTGGTGAAAAAGTTATGCTTAATTGACAAAATAATTGAGTATTTAAATGAATGTGTGAGTCAAGATGGCAAGGTTGTAGAATGTTTGGT ACAACCATGCCTCACACTCTTGAGGAAGGTTTTATGTGGTGATCCAGTCATGCGTGTTTCGCTCTCGCAACAGTCTTCTCTTTTGACCGT GTTATTCAGAGTTTCCTTAATATTTCATGAAGATTGTAGTGTCGTGACTGAAGTTGGAGCACTATTTTGTCTTCTATTATTTGATGAAGT ATCGAGAATGGATATGTGGTCTGTTAATCCTTCCAATAAACCTTCTTTGCCATCGGTCTTCAGTTTGCCTGTTTCCGTTTTTAGAAGGTA CCATCTACCTGTTCATGTAATTGGACACCATGCTGTGAGTCCTTACTCCATAGTTTTGCCCTTATCTGCTGATTGTTTGGCCTTGAAGCC GGTGTCAGATATGCTGAGAATAGCTTGGAACCTGTCATGGTATCATGGGAGTGATAATCTGTTGAAGCAAATGAACTCTGAAACTAAAAC GCAAGAAATTTTAGATGCATTGAAGTTATCTACAGAGGACATCCTCACTCTGAAGATAACACACATGGCTAGTGGGCTGCAGGACTGCCT CCATTCCATTGTTCAGGCTGCAACCCACAGGGAAGTTAGGGCTGCTGTCACCAGGATGAGTTTTTATCTTCTGAATGACAGATTGTCTTT AAAGGGTTGCCCTGGTCCATGTGGGGTTACCTTGAAGTCCTTGGCTTGGCACACCGCACTAAACAGGTTTTTACAGGTGCTTCCTGCTTG CACTGAAGATGAGAAACTGCTAATAGATATCATACATTTTTTAAATAAATTAATAAAGGAACAAAGAAAAAATTCTTCACTAGAACTTCT AAACTGGATTCTCGAATTACTTCTTAGACATAGTGCAAACCCACTGTTAGACCTCTTGGTTCTGACAGAGTCACAGGCACGAGAAGAAAC AGATGATATCCGGACTGCTGTCAGGCAACAACTTCAGAAAGAACTGATTGCTCTTTTTGATACCTTGCTGCTCAATTTCATGGAAGTTAC TGACAGGAAATGCTCGGAACTTCTTTACGTTTTTCAAACGCAGCTGGCTCTGAAACTGCTCCAGTGTCTGAAAGTGACGGATGCGCCTCA TTTCTATGGCCTGCCGTCCCTTGAGCGGACCTTACGAGGGATGGCTAACCTCACTGCGTTTCCGGGATGGAGCTCACACTCTCCTCTCAC AAAGCCTCTAGATATCTGTGTGAAGTACTTGTCAGGTCTCCTTGAGGTCATTACTTCTTTTTATGTGGAGCGTGGAGGAAATGCTATGTC CTTCATGGGAAAAGGTGTTACAAAGAGCACAATTCTTTGCTTGCTTCACTTATCCCATGAGATGATGGCCCAGGCTGGGAGCTTGGAGTG GATGTCACTTTGGTTCTTGCCTTTGGGTAGTCATAGTGAAGAACATATTCCTACTCAACAAGGATTGGCTTGGTTGATTCCATTATGGGT TGATCGGGACCCAGAGGTGAGATTCACTTCACTGGGATTAGGATCAGCACTGACCACCCTTGAAACGGGCTGTGTGGCCTTAGCAAACAG TTGTCAGAACATTTCCGGTGGGCTCTGGGGAACTGTGGTGAACATTCTTCTGGACCAGTCAGAATGTAGTATGGTGCGCCGGGAGGCGGC ATTTATTCTTCAGAATCTCCTTGTAATTCCAATGCCTACAGAAATTATAAAGGATTATACTTGGCAGGGTCCCTGTGTTCATGATGAGGA CTCTGGCCTATCGCTCATTGGAAAACCTGCCCTTCAGGCTCTTTTATATCACTGCCATTTTTATGAACATTTGAATCAGATGGTAAAGCA TTGTTACCTAGGACGGTGTATGTTTGATTTGAATTTTTCTGCTTTTGATAGAAATTCAGAAAGCAATGATTTAAATGGTTTAGATGACTC ATTCAAGTTTTGGAGGGCTCCATCTAGGACAAGTCAGGATCGAGATCCAAGTTCTCTCTCCACCTCAGAAACAACGGTGGCACCTTCATT GGGGAGTACTGAATTTCAGCCACTTGTGCAGTCAACAACACTTCTACCTGAAGCCTCCCATGACCAGTTTGTGGCTCAAGGTCACCAGGA AAGTACATCACCACGGCCACCTCATGATTCATCTCTTTCTGCTCCCCTGCCCAAACTGTGTGTTTTTGTTACTCCATCTCTTCTTTCAGC AATGTGCAGCCTCTTGGACAACCTCTTGACGATTGCTCCCAGAGACACTGCAAAGGCTTTTCGACAAGCTCATCTCATAGAACTTCTCTG TAGCATTGCAGATGCTACCCTCATACAGACATGTGTCCAGGAACTCAGAGCCCTGCTGCCTTCATCACCTCCAGCTGAACACACTCAGGC TCAGGTTTCCTTTCTCCTGGAATACCTATCCTCTTTGTCCAGGCTTCTGCAGTCATGTTTATTGGTGGAGCCTGACCTTGTGATTCAGGA TGAGCTTGTGAAACCTCTTATCACCAATATCATTGGAATTCTCACCATATGTACCAAAGATGTATTAGATAAAGAGTTAATATCAGCTTT TTATCACACATGGACACATTTATTTAATCTTCTGGCCATGCTCCTGAGGAAAGCTGGTGCCATCACACTCCCGTTTGTTACCGTGGCCCT GGCCAAGCACTGGACAGCGGCGATTGATATGTTCTGCACATGTGCAGGCTTGTCTGCCACGTGTCCTGCCCTGTATACTGCCAGCTTGCA ATTCCTTTCTGTTCTCTTGACCGAAGAAGCAAAAGGGCATCTCCAGGCTAAGAGCAAAACACATTTATGCTGTAGTCCAACAGTGGCTTC ACTTCTTGATGACTCTCAGGAAAATCAGAAATCTCTAGAACAACTTAGTGATGTAATCCTTCAGTGCTATGAAGGGAAATCCTCCAAAGA TATCCTGAAAAGAGTAGCTGCAAATGCATTGATGTCACTGCTGGCTGTCAGTAGAAGAGCACAGAAACATGCTTTGAAAGCCAATCTTAT AGACAATTGCATGGAGCAGATGAAACACATAAATGCACAACTGAACCTAGATTCTCTGAGGCCTGGGAAAGCAGCATTGAAAAAAAAGGA GGATGGTGTTATTAAAGAGTTAAGCATTGCCATGCAGCTCCTAAGAAACTGTCTTTATCAAAATGAGGAATGTAAAGAAGCAGCTCTTGA AGCTCACCTTGTCCCTGTCTTGCACTCTCTCTGGCCTTGGATTTTGATGGATGATTCATTGATGCAAATTTCTCTGCAGCTCCTTTGTGT CTATACTGCAAATTTTCCAAATGGTTGCAGTTCTCTTTGTTGGTCAAGTTGTGGACAACACCCTGTTCAAGCTACACATAGAGGAGCCGT GAGCAACTCTCTGATGCTGTGTATCCTAAAGTTGGCTTCCCAGATGCCACTGGAGAACACCACGGTTCAGCAGATGGTTTTTATGCTTCT TTCAAACCTGGCCTTGTCGCATGACTGTAAAGGAGTAATTCAGAAGAGTAACTTCTTACAGAACTTCCTCTCTCTAGCATTGCCAAAAGG AGGAAATAAACATCTAAGTAATCTGACTATTCTTTGGTTGAAGTTACTCCTGAATATATCATCTGGAGAAGATGGGCAACAAATGATTCT GAGGCTTGATGGCTGTCTAGACTTACTAACAGAGATGAGCAAATACAAGCACAAGAGCAGCCCTTTATTGCCTCTTCTTATCTTTCATAA TGTTTGCTTCAGTCCTGCAAATAAACCCAAGATCCTGGCTAATGAAAAAGTCATTACTGTGCTTGCTGCCTGTCTGGAAAGTGAGAATCA AAATGCTCAGAGGATTGGAGCAGCTGCCCTTTGGGCTCTGATTTACAATTATCAGAAGGCAAAAACAGCTTTGAAAAGCCCATCAGTAAA AAGAAGAGTGGATGAAGCATACTCCTTAGCAAAGAAAACTTTCCCAAACTCAGAAGCAAACCCTCTAAATGCCTATTATTTGAAATGTCT TGAAAACCTCGTGCAGCTCCTTAATTCTTCCTGAGTGCCATGGGATGCTACACCTTGAAGCTGACAGTCATCAACAGGGGAGCTAAAGTT GAAGCCAGCTGTGTGTAGCAGCTGTTACCTGAAGACGTGCTACCTCTCTACAAAGTGTTGATCCCCTTCTTTCCCATGAGAGAGAGAACT GGTGATACTCCAACACCGTCCAGTTGTGGCAGCTCTCCAGAAGTAATAGCAGCTGACAACTTTCTGTGCCTTTTCCTTTCTGTTGAAAAG GCATAGAAAGTTCTGGGAACATAAACATTTTTACCCTTTTCTATGCCATTTATTTTGTAAAAATCCTATTTAACAGTTATTTAATAAAAC >6354_6354_7_ARHGEF7-RTTN_ARHGEF7_chr13_111806338_ENST00000375741_RTTN_chr18_67817969_ENST00000255674_length(amino acids)=1733AA_BP=148 MRRRLTAGRGARRSGPGRTCWAAPSQSPAPAARWARRRRRRRGPRAGPPLRGEGARPSPPASRAAAMNSAEQTVTWLITLGVLESPKKTI SDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEPRSESECLSNIREFLRGCGASLRLEECLGVHNVTKPVSSLCNGIHFLLHPKVLYE ISVFGIQEPESEVNTAAKAILLYLLQGRLMMTALTWNKFIESLCPVIPILQGYADTEDPLGNCILLLSKASSDTEEMLPCTTRLKSMLRL LLVKKPSVRSLALKLLAFHLTSEEGADTKRPLIDARVLSRVTDLFIGKKPIELRLDDRRELVIKLETVEKVYEIFTSDDVDLVLRKSAAE QLAVIMQDIKMHAVVKKLCLIDKIIEYLNECVSQDGKVVECLVQPCLTLLRKVLCGDPVMRVSLSQQSSLLTVLFRVSLIFHEDCSVVTE VGALFCLLLFDEVSRMDMWSVNPSNKPSLPSVFSLPVSVFRRYHLPVHVIGHHAVSPYSIVLPLSADCLALKPVSDMLRIAWNLSWYHGS DNLLKQMNSETKTQEILDALKLSTEDILTLKITHMASGLQDCLHSIVQAATHREVRAAVTRMSFYLLNDRLSLKGCPGPCGVTLKSLAWH TALNRFLQVLPACTEDEKLLIDIIHFLNKLIKEQRKNSSLELLNWILELLLRHSANPLLDLLVLTESQAREETDDIRTAVRQQLQKELIA LFDTLLLNFMEVTDRKCSELLYVFQTQLALKLLQCLKVTDAPHFYGLPSLERTLRGMANLTAFPGWSSHSPLTKPLDICVKYLSGLLEVI TSFYVERGGNAMSFMGKGVTKSTILCLLHLSHEMMAQAGSLEWMSLWFLPLGSHSEEHIPTQQGLAWLIPLWVDRDPEVRFTSLGLGSAL TTLETGCVALANSCQNISGGLWGTVVNILLDQSECSMVRREAAFILQNLLVIPMPTEIIKDYTWQGPCVHDEDSGLSLIGKPALQALLYH CHFYEHLNQMVKHCYLGRCMFDLNFSAFDRNSESNDLNGLDDSFKFWRAPSRTSQDRDPSSLSTSETTVAPSLGSTEFQPLVQSTTLLPE ASHDQFVAQGHQESTSPRPPHDSSLSAPLPKLCVFVTPSLLSAMCSLLDNLLTIAPRDTAKAFRQAHLIELLCSIADATLIQTCVQELRA LLPSSPPAEHTQAQVSFLLEYLSSLSRLLQSCLLVEPDLVIQDELVKPLITNIIGILTICTKDVLDKELISAFYHTWTHLFNLLAMLLRK AGAITLPFVTVALAKHWTAAIDMFCTCAGLSATCPALYTASLQFLSVLLTEEAKGHLQAKSKTHLCCSPTVASLLDDSQENQKSLEQLSD VILQCYEGKSSKDILKRVAANALMSLLAVSRRAQKHALKANLIDNCMEQMKHINAQLNLDSLRPGKAALKKKEDGVIKELSIAMQLLRNC LYQNEECKEAALEAHLVPVLHSLWPWILMDDSLMQISLQLLCVYTANFPNGCSSLCWSSCGQHPVQATHRGAVSNSLMLCILKLASQMPL ENTTVQQMVFMLLSNLALSHDCKGVIQKSNFLQNFLSLALPKGGNKHLSNLTILWLKLLLNISSGEDGQQMILRLDGCLDLLTEMSKYKH KSSPLLPLLIFHNVCFSPANKPKILANEKVITVLAACLESENQNAQRIGAAALWALIYNYQKAKTALKSPSVKRRVDEAYSLAKKTFPNS -------------------------------------------------------------- >6354_6354_8_ARHGEF7-RTTN_ARHGEF7_chr13_111806338_ENST00000375741_RTTN_chr18_67817969_ENST00000437017_length(transcript)=3355nt_BP=502nt GCGGCCGAGGCCGGGGGGCGGCGGCGGGCGCCCGCAGGTTCCCGAGCCGCTCCTGAGAAGGCGCCTGACAGCGGGCCGGGGCGCACGGAG AAGCGGGCCGGGCCGGACCTGCTGGGCCGCGCCGAGCCAATCGCCGGCGCCGGCCGCTCGATGGGCGAGGCGGCGGCGGCGGCGGCGGGG GCCGCGGGCCGGGCCGCCGCTCCGAGGTGAAGGCGCGCGCCCCTCCCCGCCTGCCTCCCGGGCCGCAGCGATGAATTCCGCCGAGCAAAC CGTTACGTGGCTCATCACTCTGGGGGTGCTGGAGTCGCCCAAAAAAACCATCTCGGACCCGGAGGGCTTTCTGCAGGCGTCGCTGAAGGA TGGGGTGGTCCTCTGCAGGCTGCTGGAGCGCCTGCTCCCCGGGACCATCGAGAAAGTCTACCCCGAGCCCCGGAGCGAGAGCGAGTGCCT GAGCAACATCCGCGAGTTCCTGCGCGGCTGCGGGGCTTCCCTGCGGCTGGAGGAATGTTTAGGTGTCCATAATGTCACTAAACCCGTGTC TTCACTTTGCAATGGAATTCATTTTCTACTTCATCCAAAAGTTCTGTATGAAATCTCTGTATTTGGCATTCAAGAGCCCGAAAGTGAGGT GAACACTGCTGCCAAGGCCATTCTGTTATACCTGCTTCAGGGACGATTGATGATGACAGCATTGACCTGGAACAAGTTTATTGAATCTCT CTGTCCTGTCATCCCAATACTACAGGGCTATGCCGACACAGAAGATCCTCTGGGTAACTGCATTCTCCTTCTAAGCAAAGCAAGTTCTGA CACAGAAGAGATGCTTCCGTGTACTACCCGATTAAAGTCCATGCTGCGACTTTTGCTAGTGAAAAAGCCATCGGTCCGTTCGCTAGCATT AAAGCTTTTAGCATTCCATCTTACCAGTGAAGAAGGGGCTGATACAAAGCGTCCTCTAATAGACGCCAGAGTTCTCTCCAGAGTTACTGA TTTATTCATTGGGAAGAAACCTATTGAACTCAGACTGGATGACAGAAGAGAGCTGGTTATTAAGTTGGAGACTGTTGAAAAGGTATATGA AATCTTCACCTCAGATGATGTTGATCTCGTTTTGAGAAAGTCAGCTGCTGAACAGTTAGCTGTGATTATGCAAGATATTAAAATGCATGC TGTGGTGAAAAAGTTATGCTTAATTGACAAAATAATTGAGTATTTAAATGAATGTGTGAGTCAAGATGGCAAGGTTGTAGAATGTTTGGT ACAACCATGCCTCACACTCTTGAGGAAGGTTTTATGTGGTGATCCAGTCATGCGTGTTTCGCTCTCGCAACAGTCTTCTCTTTTGACCGT GTTATTCAGAGTTTCCTTAATATTTCATGAAGATTGTAGTGTCGTGACTGAAGTTGGAGCACTATTTTGTCTTCTATTATTTGATGAAGT ATCGAGAATGGATATGTGGTCTGTTAATCCTTCCAATAAACCTTCTTTGCCATCGGTCTTCAGTTTGCCTGTTTCCGTTTTTAGAAGGTA CCATCTACCTGTTCATGTAATTGGACACCATGCTGTGAGTCCTTACTCCATAGTTTTGCCCTTATCTGCTGATTGTTTGGCCTTGAAGCC GGTGTCAGATATGCTGAGAATAGCTTGGAACCTGTCATGGTATCATGGGAGTGATAATCTGTTGAAGCAAATGAACTCTGAAACTAAAAC GCAAGAAATTTTAGATGCATTGAAGTTATCTACAGAGGACATCCTCACTCTGAAGATAACACACATGGCTAGTGGGCTGCAGGACTGCCT CCATTCCATTGTTCAGGCTGCAACCCACAGGGAAGTTAGGGCTGCTGTCACCAGGATGAGTTTTTATCTTCTGAATGACAGATTGTCTTT AAAGGGTTGCCCTGGTCCATGTGGGGTTACCTTGAAGTCCTTGGCTTGGCACACCGCACTAAACAGGTTTTTACAGGTGCTTCCTGCTTG CACTGAAGATGAGAAACTGCTAATAGATATCATACATTTTTTAAATAAATTAATAAAGGAACAAAGAAAAAATTCTTCACTAGAACTTCT AAACTGGATTCTCGAATTACTTCTTAGACATAGTGCAAACCCACTGTTAGACCTCTTGGTTCTGACAGAGTCACAGGCACGAGAAGAAAC AGATGATATCCGGACTGCTGTCAGGCAACAACTTCAGAAAGAACTGATTGCTCTTTTTGATACCTTGCTGCTCAATTTCATGGAAGTTAC TGACAGGAAATGCTCGGAACTTCTTTACGTTTTTCAAACGCAGCTGGCTCTGAAACTGCTCCAGTGTCTGAAAGTGACGGATGCGCCTCA TTTCTATGGCCTGCCGTCCCTTGAGCGGACCTTACGAGGGATGGCTAACCTCACTGCGTTTCCGGGATGGAGCTCACACTCTCCTCTCAC AAAGCCTCTAGATATCTGTGTGAAGTACTTGTCAGGTCTCCTTGAGGTCATTACTTCTTTTTATGTGGAGCGTGGAGGAAATGCTATGTC CTTCATGGGAAAAGGTGTTACAAAGAGCACAATTCTTTGCTTGCTTCACTTATCCCATGAGATGATGGCCCAGGCTGGGAGCTTGGAGTG GATGTCACTTTGGTTCTTGCCTTTGGGTAGTCATAGTGAAGAACATATTCCTACTCAACAAGGATTGGCTTGGTTGATTCCATTATGGGT TGATCGGGACCCAGAGGTGAGATTCACTTCACTGGGATTAGGATCAGCACTGACCACCCTTGAAACGGGCTGTGTGGCCTTAGCAAACAG TTGTCAGAACATTTCCGGTGGGCTCTGGGGAACTGTGGTGAACATTCTTCTGGACCAGTCAGAATGTAGTATGGTGCGCCGGGAGGCGGC ATTTATTCTTCAGAATCTCCTTGTAATTCCAATGCCTACAGAAATTATAAAGGATTATACTTGGCAGGGTCCCTGTGTTCATGATGAGGA CTCTGGCCTATCGCTCATTGGAAAACCTGCCCTTCAGGCTCTTTTATATCACTGCCATTTTTATGAACATTTGAATCAGATGGTAAAGCA TTGTTACCTAGGACGGTGTATGTTTGATTTGAATTTTTCTGCTTTTGATAGAAATTCAGAAAGCAATGATTTAAATGGTTTAGATGACTC ATTCAAGTTTTGGAGGGCTCCATCTAGGACAAGTCAGGATCGAGATCCAAGTTCTCTCTCCACCTCAGAAACAACGGTGGCACCTTCATT GGGGAGTACTGAATTTCAGCCACTTGTGCAGTCAACAACACTTCTACCTGAAGCCTCCCATGACCAGTTTGTGGCTCAAGGGAATCGACA >6354_6354_8_ARHGEF7-RTTN_ARHGEF7_chr13_111806338_ENST00000375741_RTTN_chr18_67817969_ENST00000437017_length(amino acids)=1101AA_BP=148 MRRRLTAGRGARRSGPGRTCWAAPSQSPAPAARWARRRRRRRGPRAGPPLRGEGARPSPPASRAAAMNSAEQTVTWLITLGVLESPKKTI SDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEPRSESECLSNIREFLRGCGASLRLEECLGVHNVTKPVSSLCNGIHFLLHPKVLYE ISVFGIQEPESEVNTAAKAILLYLLQGRLMMTALTWNKFIESLCPVIPILQGYADTEDPLGNCILLLSKASSDTEEMLPCTTRLKSMLRL LLVKKPSVRSLALKLLAFHLTSEEGADTKRPLIDARVLSRVTDLFIGKKPIELRLDDRRELVIKLETVEKVYEIFTSDDVDLVLRKSAAE QLAVIMQDIKMHAVVKKLCLIDKIIEYLNECVSQDGKVVECLVQPCLTLLRKVLCGDPVMRVSLSQQSSLLTVLFRVSLIFHEDCSVVTE VGALFCLLLFDEVSRMDMWSVNPSNKPSLPSVFSLPVSVFRRYHLPVHVIGHHAVSPYSIVLPLSADCLALKPVSDMLRIAWNLSWYHGS DNLLKQMNSETKTQEILDALKLSTEDILTLKITHMASGLQDCLHSIVQAATHREVRAAVTRMSFYLLNDRLSLKGCPGPCGVTLKSLAWH TALNRFLQVLPACTEDEKLLIDIIHFLNKLIKEQRKNSSLELLNWILELLLRHSANPLLDLLVLTESQAREETDDIRTAVRQQLQKELIA LFDTLLLNFMEVTDRKCSELLYVFQTQLALKLLQCLKVTDAPHFYGLPSLERTLRGMANLTAFPGWSSHSPLTKPLDICVKYLSGLLEVI TSFYVERGGNAMSFMGKGVTKSTILCLLHLSHEMMAQAGSLEWMSLWFLPLGSHSEEHIPTQQGLAWLIPLWVDRDPEVRFTSLGLGSAL TTLETGCVALANSCQNISGGLWGTVVNILLDQSECSMVRREAAFILQNLLVIPMPTEIIKDYTWQGPCVHDEDSGLSLIGKPALQALLYH CHFYEHLNQMVKHCYLGRCMFDLNFSAFDRNSESNDLNGLDDSFKFWRAPSRTSQDRDPSSLSTSETTVAPSLGSTEFQPLVQSTTLLPE -------------------------------------------------------------- >6354_6354_9_ARHGEF7-RTTN_ARHGEF7_chr13_111806338_ENST00000375741_RTTN_chr18_67817969_ENST00000454359_length(transcript)=5507nt_BP=502nt GCGGCCGAGGCCGGGGGGCGGCGGCGGGCGCCCGCAGGTTCCCGAGCCGCTCCTGAGAAGGCGCCTGACAGCGGGCCGGGGCGCACGGAG AAGCGGGCCGGGCCGGACCTGCTGGGCCGCGCCGAGCCAATCGCCGGCGCCGGCCGCTCGATGGGCGAGGCGGCGGCGGCGGCGGCGGGG GCCGCGGGCCGGGCCGCCGCTCCGAGGTGAAGGCGCGCGCCCCTCCCCGCCTGCCTCCCGGGCCGCAGCGATGAATTCCGCCGAGCAAAC CGTTACGTGGCTCATCACTCTGGGGGTGCTGGAGTCGCCCAAAAAAACCATCTCGGACCCGGAGGGCTTTCTGCAGGCGTCGCTGAAGGA TGGGGTGGTCCTCTGCAGGCTGCTGGAGCGCCTGCTCCCCGGGACCATCGAGAAAGTCTACCCCGAGCCCCGGAGCGAGAGCGAGTGCCT GAGCAACATCCGCGAGTTCCTGCGCGGCTGCGGGGCTTCCCTGCGGCTGGAGGAATGTTTAGGTGTCCATAATGTCACTAAACCCGTGTC TTCACTTTGCAATGGAATTCATTTTCTACTTCATCCAAAAGTTCTGTATGAAATCTCTGTATTTGGCATTCAAGAGCCCGAAAGTGAGGT GAACACTGCTGCCAAGGCCATTCTGTTATACCTGCTTCAGGGACGATTGATGATGACAGCATTGACCTGGAACAAGTTTATTGAATCTCT CTGTCCTGTCATCCCAATACTACAGGGCTATGCCGACACAGAAGATCCTCTGGGTAACTGCATTCTCCTTCTAAGCAAAGCAAGTTCTGA CACAGAAGAGATGCTTCCGTGTACTACCCGATTAAAGTCCATGCTGCGACTTTTGCTAGTGAAAAAGCCATCGGTCCGTTCGCTAGCATT AAAGCTTTTAGCATTCCATCTTACCAGTGAAGAAGGGGCTGATACAAAGCGTCCTCTAATAGACGCCAGAGTTCTCTCCAGAGTTACTGA TTTATTCATTGGGAAGAAACCTATTGAACTCAGACTGGATGACAGAAGAGAGCTGGTTATTAAGTTGGAGACTGTTGAAAAGGTATATGA AATCTTCACCTCAGATGATGTTGATCTCGTTTTGAGAAAGTCAGCTGCTGAACAGTTAGCTGTGATTATGCAAGGTTGTAGAATGTTTGG TACAACCATGCCTCACACTCTTGAGGAAGGTTTTATGTGGTGATCCAGTCATGCGTGTTTCGCTCTCGCAACAGTCTTCTCTTTTGACCG TGTTATTCAGAGTTTCCTTAATATTTCATGAAGATTGTAGTGTCGTGACTGAAGTTGGAGCACTATTTTGTCTTCTATTATTTGATGAAG TATCGAGAATGGATATGTGGTCTGTTAATCCTTCCAATAAACCTTCTTTGCCATCGGTCTTCAGTTTGCCTGTTTCCGTTTTTAGAAGGT ACCATCTACCTGTTCATGTAATTGGACACCATGCTGTGAGTCCTTACTCCATAGTTTTGCCCTTATCTGCTGATTGTTTGGCCTTGAAGC CGGTGTCAGATATGCTGAGAATAGCTTGGAACCTGTCATGGTATCATGGGAGTGATAATCTGTTGAAGCAAATGAACTCTGAAACTAAAA CGCAAGAAATTTTAGATGCATTGAAGTTATCTACAGAGGACATCCTCACTCTGAAGATAACACACATGGCTAGTGGGCTGCAGGACTGCC TCCATTCCATTGTTCAGGCTGCAACCCACAGGGAAGTTAGGGCTGCTGTCACCAGGATGAGTTTTTATCTTCTGAATGACAGATTGTCTT TAAAGGGTTGCCCTGGTCCATGTGGGGTTACCTTGAAGTCCTTGGCTTGGCACACCGCACTAAACAGGTTTTTACAGGTGCTTCCTGCTT GCACTGAAGATGAGAAACTGCTAATAGATATCATACATTTTTTAAATAAATTAATAAAGGAACAAAGAAAAAATTCTTCACTAGAACTTC TAAACTGGATTCTCGAATTACTTCTTAGACATAGTGCAAACCCACTGTTAGACCTCTTGGTTCTGACAGAGTCACAGGCACGAGAAGAAA CAGATGATATCCGGACTGCTGTCAGGCAACAACTTCAGAAAGAACTGATTGCTCTTTTTGATACCTTGCTGCTCAATTTCATGGAAGTTA CTGACAGGAAATGCTCGGAACTTCTTTACGTTTTTCAAACGCAGCTGGCTCTGAAACTGCTCCAGTGTCTGAAAGTGACGGATGCGCCTC ATTTCTATGGCCTGCCGTCCCTTGAGCGGACCTTACGAGGGATGGCTAACCTCACTGCGTTTCCGGGATGGAGCTCACACTCTCCTCTCA CAAAGCCTCTAGATATCTGTGTGAAGTACTTGTCAGGTCTCCTTGAGGTCATTACTTCTTTTTATGTGGAGCGTGGAGGAAATGCTATGT CCTTCATGGGAAAAGGTGTTACAAAGAGCACAATTCTTTGCTTGCTTCACTTATCCCATGAGATGATGGCCCAGGCTGGGAGCTTGGAGT GGATGTCACTTTGGTTCTTGCCTTTGGGTAGTCATAGTGAAGAACATATTCCTACTCAACAAGGATTGGCTTGGTTGATTCCATTATGGG TTGATCGGGACCCAGAGGTGAGATTCACTTCACTGGGATTAGGATCAGCACTGACCACCCTTGAAACGGGCTGTGTGGCCTTAGCAAACA GTTGTCAGAACATTTCCGGTGGGCTCTGGGGAACTGTGGTGAACATTCTTCTGGACCAGTCAGAATGTAGTATGGTGCGCCGGGAGGCGG CATTTATTCTTCAGAATCTCCTTGTAATTCCAATGCCTACAGAAATTATAAAGGATTATACTTGGCAGGGTCCCTGTGTTCATGATGAGG ACTCTGGCCTATCGCTCATTGGAAAACCTGCCCTTCAGGCTCTTTTATATCACTGCCATTTTTATGAACATTTGAATCAGATGGTAAAGC ATTGTTACCTAGGACGGTGTATGTTTGATTTGAATTTTTCTGCTTTTGATAGAAATTCAGAAAGCAATGATTTAAATGGTTTAGATGACT CATTCAAGTTTTGGAGGGCTCCATCTAGGACAAGTCAGGATCGAGATCCAAGTTCTCTCTCCACCTCAGAAACAACGGTGGCACCTTCAT TGGGGAGTACTGAATTTCAGCCACTTGTGCAGTCAACAACACTTCTACCTGAAGCCTCCCATGACCAGTTTGTGGCTCAAGGTCACCAGG AAAGTACATCACCACGGCCACCTCATGATTCATCTCTTTCTGCTCCCCTGCCCAAACTGTGTGTTTTTGTTACTCCATCTCTTCTTTCAG CAATGTGCAGCCTCTTGGACAACCTCTTGACGATTGCTCCCAGAGACACTGCAAAGGCTTTTCGACAAGCTCATCTCATAGAACTTCTCT GTAGCATTGCAGATGCTACCCTCATACAGACATGTGTCCAGGAACTCAGAGCCCTGCTGCCTTCATCACCTCCAGCTGAACACACTCAGG CTCAGGTTTCCTTTCTCCTGGAATACCTATCCTCTTTGTCCAGGCTTCTGCAGTCATGTTTATTGGTGGAGCCTGACCTTGTGATTCAGG ATGAGCTTGTGAAACCTCTTATCACCAATATCATTGGAATTCTCACCATATGTACCAAAGATGTATTAGATAAAGAGTTAATATCAGCTT TTTATCACACATGGACACATTTATTTAATCTTCTGGCCATGCTCCTGAGGAAAGCTGGTGCCATCACACTCCCGTTTGTTACCGTGGCCC TGGCCAAGCACTGGACAGCGGCGATTGATATGTTCTGCACATGTGCAGGCTTGTCTGCCACGTGTCCTGCCCTGTATACTGCCAGCTTGC AATTCCTTTCTGTTCTCTTGACCGAAGAAGCAAAAGGGCATCTCCAGGCTAAGAGCAAAACACATTTATGCTGTAGTCCAACAGTGGCTT CACTTCTTGATGACTCTCAGGAAAATCAGAAATCTCTAGAACAACTTAGTGATGTAATCCTTCAGTGCTATGAAGGGAAATCCTCCAAAG ATATCCTGAAAAGAGTAGCTGCAAATGCATTGATGTCACTGCTGGCTGTCAGTAGAAGAGCACAGAAACATGCTTTGAAAGCCAATCTTA TAGACAATTGCATGGAGCAGATGAAACACATAAATGCACAACTGAACCTAGATTCTCTGAGGCCTGGGAAAGCAGCATTGAAAAAAAAGG AGGATGGTGTTATTAAAGAGTTAAGCATTGCCATGCAGCTCCTAAGAAACTGTCTTTATCAAAATGAGGAATGTAAAGAAGCAGCTCTTG AAGCTCACCTTGTCCCTGTCTTGCACTCTCTCTGGCCTTGGATTTTGATGGATGATTCATTGATGCAAATTTCTCTGCAGCTCCTTTGTG TCTATACTGCAAATTTTCCAAATGGTTGCAGTTCTCTTTGTTGGTCAAGTTGTGGACAACACCCTGTTCAAGCTACACATAGAGGAGCCG TGAGCAACTCTCTGATGCTGTGTATCCTAAAGTTGGCTTCCCAGATGCCACTGGAGAACACCACGGTTCAGCAGATGGTTTTTATGCTTC TTTCAAACCTGGCCTTGTCGCATGACTGTAAAGGAGTAATTCAGAAGAGTAACTTCTTACAGAACTTCCTCTCTCTAGCATTGCCAAAAG GAGGAAATAAACATCTAAGTAATCTGACTATTCTTTGGTTGAAGTTACTCCTGAATATATCATCTGGAGAAGATGGGCAACAAATGATTC TGAGGCTTGATGGCTGTCTAGACTTACTAACAGAGATGAGCAAATACAAGCACAAGAGCAGCCCTTTATTGCCTCTTCTTATCTTTCATA ATGTTTGCTTCAGTCCTGCAAATAAACCCAAGATCCTGGCTAATGAAAAAGTCATTACTGTGCTTGCTGCCTGTCTGGAAAGTGAGAATC AAAATGCTCAGAGGATTGGAGCAGCTGCCCTTTGGGCTCTGATTTACAATTATCAGAAGGCAAAAACAGCTTTGAAAAGCCCATCAGTAA AAAGAAGAGTGGATGAAGCATACTCCTTAGCAAAGAAAACTTTCCCAAACTCAGAAGCAAACCCTCTAAATGCCTATTATTTGAAATGTC TTGAAAACCTCGTGCAGCTCCTTAATTCTTCCTGAGTGCCATGGGATGCTACACCTTGAAGCTGACAGTCATCAACAGGGGAGCTAAAGT TGAAGCCAGCTGTGTGTAGCAGCTGTTACCTGAAGACGTGCTACCTCTCTACAAAGTGTTGATCCCCTTCTTTCCCATGAGAGAGAGAAC TGGTGATACTCCAACACCGTCCAGTTGTGGCAGCTCTCCAGAAGTAATAGCAGCTGACAACTTTCTGTGCCTTTTCCTTTCTGTTGAAAA GGCATAGAAAGTTCTGGGAACATAAACATTTTTACCCTTTTCTATGCCATTTATTTTGTAAAAATCCTATTTAACAGTTATTTAATAAAA >6354_6354_9_ARHGEF7-RTTN_ARHGEF7_chr13_111806338_ENST00000375741_RTTN_chr18_67817969_ENST00000454359_length(amino acids)=1332AA_BP= MVQPCLTLLRKVLCGDPVMRVSLSQQSSLLTVLFRVSLIFHEDCSVVTEVGALFCLLLFDEVSRMDMWSVNPSNKPSLPSVFSLPVSVFR RYHLPVHVIGHHAVSPYSIVLPLSADCLALKPVSDMLRIAWNLSWYHGSDNLLKQMNSETKTQEILDALKLSTEDILTLKITHMASGLQD CLHSIVQAATHREVRAAVTRMSFYLLNDRLSLKGCPGPCGVTLKSLAWHTALNRFLQVLPACTEDEKLLIDIIHFLNKLIKEQRKNSSLE LLNWILELLLRHSANPLLDLLVLTESQAREETDDIRTAVRQQLQKELIALFDTLLLNFMEVTDRKCSELLYVFQTQLALKLLQCLKVTDA PHFYGLPSLERTLRGMANLTAFPGWSSHSPLTKPLDICVKYLSGLLEVITSFYVERGGNAMSFMGKGVTKSTILCLLHLSHEMMAQAGSL EWMSLWFLPLGSHSEEHIPTQQGLAWLIPLWVDRDPEVRFTSLGLGSALTTLETGCVALANSCQNISGGLWGTVVNILLDQSECSMVRRE AAFILQNLLVIPMPTEIIKDYTWQGPCVHDEDSGLSLIGKPALQALLYHCHFYEHLNQMVKHCYLGRCMFDLNFSAFDRNSESNDLNGLD DSFKFWRAPSRTSQDRDPSSLSTSETTVAPSLGSTEFQPLVQSTTLLPEASHDQFVAQGHQESTSPRPPHDSSLSAPLPKLCVFVTPSLL SAMCSLLDNLLTIAPRDTAKAFRQAHLIELLCSIADATLIQTCVQELRALLPSSPPAEHTQAQVSFLLEYLSSLSRLLQSCLLVEPDLVI QDELVKPLITNIIGILTICTKDVLDKELISAFYHTWTHLFNLLAMLLRKAGAITLPFVTVALAKHWTAAIDMFCTCAGLSATCPALYTAS LQFLSVLLTEEAKGHLQAKSKTHLCCSPTVASLLDDSQENQKSLEQLSDVILQCYEGKSSKDILKRVAANALMSLLAVSRRAQKHALKAN LIDNCMEQMKHINAQLNLDSLRPGKAALKKKEDGVIKELSIAMQLLRNCLYQNEECKEAALEAHLVPVLHSLWPWILMDDSLMQISLQLL CVYTANFPNGCSSLCWSSCGQHPVQATHRGAVSNSLMLCILKLASQMPLENTTVQQMVFMLLSNLALSHDCKGVIQKSNFLQNFLSLALP KGGNKHLSNLTILWLKLLLNISSGEDGQQMILRLDGCLDLLTEMSKYKHKSSPLLPLLIFHNVCFSPANKPKILANEKVITVLAACLESE -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ARHGEF7-RTTN |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ARHGEF7-RTTN |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ARHGEF7-RTTN |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | C3553831 | MICROCEPHALY, SHORT STATURE, AND POLYMICROGYRIA WITH OR WITHOUT SEIZURES | 3 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT | |
| Tgene | C0431350 | Primary microcephaly | 1 | GENOMICS_ENGLAND | |
| Tgene | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND | |
| Tgene | C4225499 | MICROCEPHALY, SHORT STATURE, AND POLYMICROGYRIA WITH SEIZURES | 1 | GENOMICS_ENGLAND |
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