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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGEF7-EXOC4 (FusionGDB2 ID:HG8874TG60412)

Fusion Gene Summary for ARHGEF7-EXOC4

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGEF7-EXOC4
Fusion gene ID: hg8874tg60412
HgeneTgene
Gene symbol

ARHGEF7

EXOC4

Gene ID

8874

60412

Gene nameRho guanine nucleotide exchange factor 7exocyst complex component 4
SynonymsBETA-PIX|COOL-1|COOL1|Nbla10314|P50|P50BP|P85|P85COOL1|P85SPR|PAK3|PIXBSEC8|SEC8L1|Sec8p
Cytomap('ARHGEF7')('EXOC4')

13q34

7q33

Type of geneprotein-codingprotein-coding
Descriptionrho guanine nucleotide exchange factor 7PAK-interacting exchange factor betaRho guanine nucleotide exchange factor (GEF) 7SH3 domain-containing proline-rich proteinexocyst complex component 4SEC8-like 1exocyst complex component Sec8
Modification date2020032720200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000317133, ENST00000370623, 
ENST00000375739, ENST00000375741, 
ENST00000218789, ENST00000375723, 
ENST00000375736, ENST00000375737, 
ENST00000426073, ENST00000478679, 
ENST00000483189, ENST00000544132, 
Fusion gene scores* DoF score25 X 17 X 12=510035 X 25 X 10=8750
# samples 2639
** MAII scorelog2(26/5100*10)=-4.29391371871777
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(39/8750*10)=-4.48773698785744
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGEF7 [Title/Abstract] AND EXOC4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGEF7(111768038)-EXOC4(133580352), # samples:2
Anticipated loss of major functional domain due to fusion event.ARHGEF7-EXOC4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF7-EXOC4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARHGEF7

GO:0043547

positive regulation of GTPase activity

21048939


check buttonFusion gene breakpoints across ARHGEF7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across EXOC4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A23R-01AARHGEF7chr13

111768038

-EXOC4chr7

133580352

+
ChimerDB4SARCTCGA-DX-A23R-01AARHGEF7chr13

111768038

+EXOC4chr7

133580352

+


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Fusion Gene ORF analysis for ARHGEF7-EXOC4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000317133ENST00000460346ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
5CDS-3UTRENST00000370623ENST00000460346ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
5CDS-3UTRENST00000375739ENST00000460346ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
5CDS-3UTRENST00000375741ENST00000460346ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
5CDS-intronENST00000317133ENST00000393161ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
5CDS-intronENST00000317133ENST00000541309ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
5CDS-intronENST00000317133ENST00000545148ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
5CDS-intronENST00000370623ENST00000393161ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
5CDS-intronENST00000370623ENST00000541309ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
5CDS-intronENST00000370623ENST00000545148ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
5CDS-intronENST00000375739ENST00000393161ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
5CDS-intronENST00000375739ENST00000541309ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
5CDS-intronENST00000375739ENST00000545148ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
5CDS-intronENST00000375741ENST00000393161ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
5CDS-intronENST00000375741ENST00000541309ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
5CDS-intronENST00000375741ENST00000545148ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
In-frameENST00000317133ENST00000253861ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
In-frameENST00000317133ENST00000539845ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
In-frameENST00000370623ENST00000253861ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
In-frameENST00000370623ENST00000539845ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
In-frameENST00000375739ENST00000253861ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
In-frameENST00000375739ENST00000539845ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
In-frameENST00000375741ENST00000253861ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
In-frameENST00000375741ENST00000539845ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-3CDSENST00000218789ENST00000253861ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-3CDSENST00000218789ENST00000539845ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-3CDSENST00000375723ENST00000253861ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-3CDSENST00000375723ENST00000539845ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-3CDSENST00000375736ENST00000253861ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-3CDSENST00000375736ENST00000539845ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-3CDSENST00000375737ENST00000253861ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-3CDSENST00000375737ENST00000539845ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-3CDSENST00000426073ENST00000253861ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-3CDSENST00000426073ENST00000539845ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-3CDSENST00000478679ENST00000253861ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-3CDSENST00000478679ENST00000539845ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-3CDSENST00000483189ENST00000253861ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-3CDSENST00000483189ENST00000539845ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-3CDSENST00000544132ENST00000253861ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-3CDSENST00000544132ENST00000539845ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-3UTRENST00000218789ENST00000460346ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-3UTRENST00000375723ENST00000460346ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-3UTRENST00000375736ENST00000460346ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-3UTRENST00000375737ENST00000460346ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-3UTRENST00000426073ENST00000460346ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-3UTRENST00000478679ENST00000460346ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-3UTRENST00000483189ENST00000460346ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-3UTRENST00000544132ENST00000460346ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-intronENST00000218789ENST00000393161ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-intronENST00000218789ENST00000541309ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-intronENST00000218789ENST00000545148ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-intronENST00000375723ENST00000393161ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-intronENST00000375723ENST00000541309ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-intronENST00000375723ENST00000545148ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-intronENST00000375736ENST00000393161ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-intronENST00000375736ENST00000541309ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-intronENST00000375736ENST00000545148ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-intronENST00000375737ENST00000393161ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-intronENST00000375737ENST00000541309ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-intronENST00000375737ENST00000545148ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-intronENST00000426073ENST00000393161ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-intronENST00000426073ENST00000541309ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-intronENST00000426073ENST00000545148ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-intronENST00000478679ENST00000393161ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-intronENST00000478679ENST00000541309ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-intronENST00000478679ENST00000545148ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-intronENST00000483189ENST00000393161ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-intronENST00000483189ENST00000541309ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-intronENST00000483189ENST00000545148ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-intronENST00000544132ENST00000393161ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-intronENST00000544132ENST00000541309ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+
intron-intronENST00000544132ENST00000545148ARHGEF7chr13

111768038

+EXOC4chr7

133580352

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000317133ARHGEF7chr13111768038+ENST00000253861EXOC4chr7133580352+349510737102263517
ENST00000317133ARHGEF7chr13111768038+ENST00000539845EXOC4chr7133580352+232310737102263517
ENST00000375741ARHGEF7chr13111768038+ENST00000253861EXOC4chr7133580352+2837415521605517
ENST00000375741ARHGEF7chr13111768038+ENST00000539845EXOC4chr7133580352+1665415521605517
ENST00000375739ARHGEF7chr13111768038+ENST00000253861EXOC4chr7133580352+2837415521605517
ENST00000375739ARHGEF7chr13111768038+ENST00000539845EXOC4chr7133580352+1665415521605517
ENST00000370623ARHGEF7chr13111768038+ENST00000253861EXOC4chr7133580352+258716501355451
ENST00000370623ARHGEF7chr13111768038+ENST00000539845EXOC4chr7133580352+141516501355451

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000317133ENST00000253861ARHGEF7chr13111768038+EXOC4chr7133580352+0.001962230.99803776
ENST00000317133ENST00000539845ARHGEF7chr13111768038+EXOC4chr7133580352+0.0060176720.99398226
ENST00000375741ENST00000253861ARHGEF7chr13111768038+EXOC4chr7133580352+0.0013681110.9986319
ENST00000375741ENST00000539845ARHGEF7chr13111768038+EXOC4chr7133580352+0.0038216410.9961784
ENST00000375739ENST00000253861ARHGEF7chr13111768038+EXOC4chr7133580352+0.0013681110.9986319
ENST00000375739ENST00000539845ARHGEF7chr13111768038+EXOC4chr7133580352+0.0038216410.9961784
ENST00000370623ENST00000253861ARHGEF7chr13111768038+EXOC4chr7133580352+0.0011926650.9988073
ENST00000370623ENST00000539845ARHGEF7chr13111768038+EXOC4chr7133580352+0.0031892790.99681073

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Fusion Genomic Features for ARHGEF7-EXOC4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARHGEF7chr13111768038+EXOC4chr7133580351+8.21E-091
ARHGEF7chr13111768038+EXOC4chr7133580351+8.21E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARHGEF7-EXOC4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:111768038/chr7:133580352)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEXOC4chr13:111768038chr7:133580352ENST0000039316101032_1140474.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGEF7chr13:111768038chr7:133580352ENST00000317133+119184_24355783.0DomainSH3
HgeneARHGEF7chr13:111768038chr7:133580352ENST00000317133+1191_13355783.0DomainCalponin-homology (CH)
HgeneARHGEF7chr13:111768038chr7:133580352ENST00000317133+119271_45155783.0DomainDH
HgeneARHGEF7chr13:111768038chr7:133580352ENST00000317133+119473_57855783.0DomainPH
HgeneARHGEF7chr13:111768038chr7:133580352ENST00000370623+119184_24355732.0DomainSH3
HgeneARHGEF7chr13:111768038chr7:133580352ENST00000370623+1191_13355732.0DomainCalponin-homology (CH)
HgeneARHGEF7chr13:111768038chr7:133580352ENST00000370623+119271_45155732.0DomainDH
HgeneARHGEF7chr13:111768038chr7:133580352ENST00000370623+119473_57855732.0DomainPH
HgeneARHGEF7chr13:111768038chr7:133580352ENST00000375723+117184_2430626.0DomainSH3
HgeneARHGEF7chr13:111768038chr7:133580352ENST00000375723+1171_1330626.0DomainCalponin-homology (CH)
HgeneARHGEF7chr13:111768038chr7:133580352ENST00000375723+117271_4510626.0DomainDH
HgeneARHGEF7chr13:111768038chr7:133580352ENST00000375723+117473_5780626.0DomainPH
HgeneARHGEF7chr13:111768038chr7:133580352ENST00000375736+120184_2430647.0DomainSH3
HgeneARHGEF7chr13:111768038chr7:133580352ENST00000375736+1201_1330647.0DomainCalponin-homology (CH)
HgeneARHGEF7chr13:111768038chr7:133580352ENST00000375736+120271_4510647.0DomainDH
HgeneARHGEF7chr13:111768038chr7:133580352ENST00000375736+120473_5780647.0DomainPH
HgeneARHGEF7chr13:111768038chr7:133580352ENST00000375739+118184_24355754.0DomainSH3
HgeneARHGEF7chr13:111768038chr7:133580352ENST00000375739+1181_13355754.0DomainCalponin-homology (CH)
HgeneARHGEF7chr13:111768038chr7:133580352ENST00000375739+118271_45155754.0DomainDH
HgeneARHGEF7chr13:111768038chr7:133580352ENST00000375739+118473_57855754.0DomainPH
HgeneARHGEF7chr13:111768038chr7:133580352ENST00000375741+120184_24355804.0DomainSH3
HgeneARHGEF7chr13:111768038chr7:133580352ENST00000375741+1201_13355804.0DomainCalponin-homology (CH)
HgeneARHGEF7chr13:111768038chr7:133580352ENST00000375741+120271_45155804.0DomainDH
HgeneARHGEF7chr13:111768038chr7:133580352ENST00000375741+120473_57855804.0DomainPH
HgeneARHGEF7chr13:111768038chr7:133580352ENST00000426073+120184_2430647.0DomainSH3
HgeneARHGEF7chr13:111768038chr7:133580352ENST00000426073+1201_1330647.0DomainCalponin-homology (CH)
HgeneARHGEF7chr13:111768038chr7:133580352ENST00000426073+120271_4510647.0DomainDH
HgeneARHGEF7chr13:111768038chr7:133580352ENST00000426073+120473_5780647.0DomainPH
TgeneEXOC4chr13:111768038chr7:133580352ENST00000253861101832_114578975.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for ARHGEF7-EXOC4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6346_6346_1_ARHGEF7-EXOC4_ARHGEF7_chr13_111768038_ENST00000317133_EXOC4_chr7_133580352_ENST00000253861_length(transcript)=3495nt_BP=1073nt
CCCCGAGACGCAGCCAGGCGCCCGGCCCGGCCCGGCCCGGCCCTCTGCACAGCCCCACTTCAGGCCACGCCGTTTCCTTGACCTTCCCCC
GGCAGGGTCTGAAGCGTCACCGTCCGTCTAGAGCAGAGTCGCGCAGGCCCCTGCCCTGCCGGTGAGGTCGGCGCCGCGCTCCGGAGAGTC
GGTTCCTCCCGATTCAGACCCATATGGCTTCAGATGGAACCATCATTTCTGTTCCGTCATGACCGGCTTGCAAGGTAGCAAAGCGAAACA
AACGTCTCGTTTTCAGCCTGTCCCCGCCACCTTGAAATAAAACCGGCAAAAATAAAAAGAGCATTCTGGGAAGTACTTCATCATTTCAAC
GCTCACGAATTCAAAACATAAACAAAGGCTTCCGAGTGCCCCGGCCAGGGGCGCGGGGCGCACGGCGGGCCCGGGGCAGGTAAGCGCAGG
TGCGCGCCCGCCCCCACCCCCGGCTCCCTCCCCATCCGCTCCCCGCTCCCCTTCCCCTTTCCCTTCCCCGCCCGCTCCCAGCCGCCGCCG
CCGCCCCGCGCACGGCCTGGAGCGGAGGCTGCGCAGGGCGCGGGGCGGCGCGGGCCGGGCGCGGGCCGGGCGGACGGCCGCGTCTTTCTT
CTCCTGGCGGTGATGTCATTGGGCGACGGCGGCCGAGGCCGGGGGGCGGCGGCGGGCGCCCGCAGGTTCCCGAGCCGCTCCTGAGAAGGC
GCCTGACAGCGGGCCGGGGCGCACGGAGAAGCGGGCCGGGCCGGACCTGCTGGGCCGCGCCGAGCCAATCGCCGGCGCCGGCCGCTCGAT
GGGCGAGGCGGCGGCGGCGGCGGCGGGGGCCGCGGGCCGGGCCGCCGCTCCGAGGTGAAGGCGCGCGCCCCTCCCCGCCTGCCTCCCGGG
CCGCAGCGATGAATTCCGCCGAGCAAACCGTTACGTGGCTCATCACTCTGGGGGTGCTGGAGTCGCCCAAAAAAACCATCTCGGACCCGG
AGGGCTTTCTGCAGGCGTCGCTGAAGGATGGGGTGGTCCTCTGCAGGCTGCTGGAGCGCCTGCTCCCCGGGACCATCGAGAAAAGCACAA
TCATTGTGGAGAAGACAGTTCAAGACCTCCTGAACCTGATGCATGACTTGAGTGCATATTCAGATCAATTCCTCAACATGGTGTGCGTGA
AGCTCCAGGAGTACAAGGACACCTGCACTGCAGCTTACAGGGGTATTGTCCAGTCAGAAGAAAAACTTGTCATCAGTGCATCCTGGGCAA
AAGATGATGATATCAGCAGACTCTTGAAATCTCTACCAAACTGGATGAATATGGCTCAACCCAAACAGCTGAGGCCAAAAAGAGAGGAGG
AAGAAGATTTCATAAGGGCAGCTTTTGGCAAGGAGTCTGAAGTTCTTATTGGGAACCTGGGTGATAAATTAATCCCTCCACAAGACATCC
TTCGTGACGTCAGTGACCTCAAAGCCTTGGCCAACATGCATGAAAGCCTGGAATGGTTGGCAAGTCGAACAAAGTCAGCTTTCTCCAATC
TTTCTACATCCCAGATGCTTTCTCCTGCTCAAGACAGCCACACGAACACGGATCTCCCCCCAGTGTCAGAGCAGATCATGCAGACTCTCA
GTGAACTTGCCAAATCGTTCCAGGATATGGCTGACCGCTGCTTGCTTGTCTTACATCTGGAAGTGAGGGTTCACTGTTTCCACTATCTTA
TCCCTCTTGCAAAGGAGGGGAACTATGCCATTGTGGCTAATGTGGAAAGTATGGATTATGACCCCCTGGTGGTCAAGCTCAACAAAGATA
TCAGCGCCATTGAAGAGGCCATGAGCGCCAGCCTTCAGCAGCACAAGTTCCAGTATATCTTCGAAGGCCTGGGCCACCTGATCTCCTGCA
TCCTCATTAATGGTGCCCAGTACTTCAGGCGCATCAGTGAGTCTGGCATCAAGAAAATGTGTAGGAACATTTTTGTTCTTCAGCAGAATT
TGACCAACATCACCATGTCGCGGGAGGCAGACCTGGACTTTGCAAGGCAGTACTACGAGATGCTTTACAACACAGCTGACGAGCTCCTGA
ACCTGGTGGTGGACCAGGGTGTGAAGTACACGGAGCTGGAGTACATCCACGCTCTGACCCTGCTGCACCGCAGCCAGACTGGGGTGGGGG
AACTGACCACCCAGAACACGAGGCTGCAGAGGCTCAAAGAGATCATCTGCGAGCAGGCTGCCATCAAGCAAGCCACCAAGGACAAGAAGA
TAACTACCGTTTAGCAGGGCGTACTGCGGTTGGTGACGGGGGTCCCCTCAGTCACACTCACTTTTTTCCTTGGTATGTTATTGAGTATAT
TCTGAGCTTAGTTTTCTCTACAGTGATACTTTAGTGGAGAGGAGGTGTAAGGATTCTTTCTCTCTGGTTTTGGCTTTTCATATAAATGCT
AAAGGAAGGCGACAGTACAGAGTGTTTTGGTTGAACAACTACTTTAATGCAGTCAAATCTAACGGGACTAGGGTGGGATAGGGAGGAAGG
TGGTATCAAATTGTTGGACTCTGAAAAACAAGTGGATGGATTACTAATATTTGATTTATTACTCAATATATATATAATTCCAGCCTTGGA
AAGTAGGAAAGTAGGCTGCTACCTAACTTTTAGTCCCTTCCAAAACCATTTAGTAGGGTTCTATTACATAAACAGTAGGGTTTTTCCTCT
CCTGACCTTATCCGTTTACAGTTCAATGAAATAAGTGTATGTGCATTGCTGTCTGTCTCTATTGCCAAAATCAAATAAATGGCTTCTCAG
CTGCTGTTTACAACAAACTTCCCTAACCAAAACAGAACCTCTAATTTAGGGCTAGGAATAGAAGTCTTTTGATCCCAGTCCCTGGGACAG
TTTTGTATGCTGTATCTTGTACACAGGTTGTAGGTTGGTTTATTGCCATTTTGTTTTATTTCTGCTGTATAAAAACCAAGAGCCAGACAA
TTAGACAACTATGGAGGAATGAAAGGCAATTCAAACATCTGCTTGATTCCCGCCCCGCCACCCCTAATTTCTGAGAGAATAATGGTTAGA
GAACATTGCATCTCACTTGAAACATCCTTTGGGGGTAAATGATTCTTAGGTGCTCACTTGGTCTGAGCTCAGCTGAATGCAGGGAAGATG
GGACAGAGTGACATTTCTCCTCTGTGCGGCCTCCAGCTGAGCCTGTCTCTGAATTGTTCCCTCCCCCGCAATGTGGGCACTTACCATGTT
CCTGGCACACTGGACCTCACCATGTCCCCCGGTCACCAGTCCTCTTGCTGCCCATGGTTCATAGGTCATAGAAGGCAGCAATGCACTGAC
TGGGCCACATCTTGAAAACTCGTGGAAAGGGAAAGGGGAGGAGATGGGACTTTGACCACACACAGTGATGCCTCACACCCTGAAGGTGGG

>6346_6346_1_ARHGEF7-EXOC4_ARHGEF7_chr13_111768038_ENST00000317133_EXOC4_chr7_133580352_ENST00000253861_length(amino acids)=517AA_BP=121
MRRRLTAGRGARRSGPGRTCWAAPSQSPAPAARWARRRRRRRGPRAGPPLRGEGARPSPPASRAAAMNSAEQTVTWLITLGVLESPKKTI
SDPEGFLQASLKDGVVLCRLLERLLPGTIEKSTIIVEKTVQDLLNLMHDLSAYSDQFLNMVCVKLQEYKDTCTAAYRGIVQSEEKLVISA
SWAKDDDISRLLKSLPNWMNMAQPKQLRPKREEEEDFIRAAFGKESEVLIGNLGDKLIPPQDILRDVSDLKALANMHESLEWLASRTKSA
FSNLSTSQMLSPAQDSHTNTDLPPVSEQIMQTLSELAKSFQDMADRCLLVLHLEVRVHCFHYLIPLAKEGNYAIVANVESMDYDPLVVKL
NKDISAIEEAMSASLQQHKFQYIFEGLGHLISCILINGAQYFRRISESGIKKMCRNIFVLQQNLTNITMSREADLDFARQYYEMLYNTAD

--------------------------------------------------------------
>6346_6346_2_ARHGEF7-EXOC4_ARHGEF7_chr13_111768038_ENST00000317133_EXOC4_chr7_133580352_ENST00000539845_length(transcript)=2323nt_BP=1073nt
CCCCGAGACGCAGCCAGGCGCCCGGCCCGGCCCGGCCCGGCCCTCTGCACAGCCCCACTTCAGGCCACGCCGTTTCCTTGACCTTCCCCC
GGCAGGGTCTGAAGCGTCACCGTCCGTCTAGAGCAGAGTCGCGCAGGCCCCTGCCCTGCCGGTGAGGTCGGCGCCGCGCTCCGGAGAGTC
GGTTCCTCCCGATTCAGACCCATATGGCTTCAGATGGAACCATCATTTCTGTTCCGTCATGACCGGCTTGCAAGGTAGCAAAGCGAAACA
AACGTCTCGTTTTCAGCCTGTCCCCGCCACCTTGAAATAAAACCGGCAAAAATAAAAAGAGCATTCTGGGAAGTACTTCATCATTTCAAC
GCTCACGAATTCAAAACATAAACAAAGGCTTCCGAGTGCCCCGGCCAGGGGCGCGGGGCGCACGGCGGGCCCGGGGCAGGTAAGCGCAGG
TGCGCGCCCGCCCCCACCCCCGGCTCCCTCCCCATCCGCTCCCCGCTCCCCTTCCCCTTTCCCTTCCCCGCCCGCTCCCAGCCGCCGCCG
CCGCCCCGCGCACGGCCTGGAGCGGAGGCTGCGCAGGGCGCGGGGCGGCGCGGGCCGGGCGCGGGCCGGGCGGACGGCCGCGTCTTTCTT
CTCCTGGCGGTGATGTCATTGGGCGACGGCGGCCGAGGCCGGGGGGCGGCGGCGGGCGCCCGCAGGTTCCCGAGCCGCTCCTGAGAAGGC
GCCTGACAGCGGGCCGGGGCGCACGGAGAAGCGGGCCGGGCCGGACCTGCTGGGCCGCGCCGAGCCAATCGCCGGCGCCGGCCGCTCGAT
GGGCGAGGCGGCGGCGGCGGCGGCGGGGGCCGCGGGCCGGGCCGCCGCTCCGAGGTGAAGGCGCGCGCCCCTCCCCGCCTGCCTCCCGGG
CCGCAGCGATGAATTCCGCCGAGCAAACCGTTACGTGGCTCATCACTCTGGGGGTGCTGGAGTCGCCCAAAAAAACCATCTCGGACCCGG
AGGGCTTTCTGCAGGCGTCGCTGAAGGATGGGGTGGTCCTCTGCAGGCTGCTGGAGCGCCTGCTCCCCGGGACCATCGAGAAAAGCACAA
TCATTGTGGAGAAGACAGTTCAAGACCTCCTGAACCTGATGCATGACTTGAGTGCATATTCAGATCAATTCCTCAACATGGTGTGCGTGA
AGCTCCAGGAGTACAAGGACACCTGCACTGCAGCTTACAGGGGTATTGTCCAGTCAGAAGAAAAACTTGTCATCAGTGCATCCTGGGCAA
AAGATGATGATATCAGCAGACTCTTGAAATCTCTACCAAACTGGATGAATATGGCTCAACCCAAACAGCTGAGGCCAAAAAGAGAGGAGG
AAGAAGATTTCATAAGGGCAGCTTTTGGCAAGGAGTCTGAAGTTCTTATTGGGAACCTGGGTGATAAATTAATCCCTCCACAAGACATCC
TTCGTGACGTCAGTGACCTCAAAGCCTTGGCCAACATGCATGAAAGCCTGGAATGGTTGGCAAGTCGAACAAAGTCAGCTTTCTCCAATC
TTTCTACATCCCAGATGCTTTCTCCTGCTCAAGACAGCCACACGAACACGGATCTCCCCCCAGTGTCAGAGCAGATCATGCAGACTCTCA
GTGAACTTGCCAAATCGTTCCAGGATATGGCTGACCGCTGCTTGCTTGTCTTACATCTGGAAGTGAGGGTTCACTGTTTCCACTATCTTA
TCCCTCTTGCAAAGGAGGGGAACTATGCCATTGTGGCTAATGTGGAAAGTATGGATTATGACCCCCTGGTGGTCAAGCTCAACAAAGATA
TCAGCGCCATTGAAGAGGCCATGAGCGCCAGCCTTCAGCAGCACAAGTTCCAGTATATCTTCGAAGGCCTGGGCCACCTGATCTCCTGCA
TCCTCATTAATGGTGCCCAGTACTTCAGGCGCATCAGTGAGTCTGGCATCAAGAAAATGTGTAGGAACATTTTTGTTCTTCAGCAGAATT
TGACCAACATCACCATGTCGCGGGAGGCAGACCTGGACTTTGCAAGGCAGTACTACGAGATGCTTTACAACACAGCTGACGAGCTCCTGA
ACCTGGTGGTGGACCAGGGTGTGAAGTACACGGAGCTGGAGTACATCCACGCTCTGACCCTGCTGCACCGCAGCCAGACTGGGGTGGGGG
AACTGACCACCCAGAACACGAGGCTGCAGAGGCTCAAAGAGATCATCTGCGAGCAGGCTGCCATCAAGCAAGCCACCAAGGACAAGAAGA

>6346_6346_2_ARHGEF7-EXOC4_ARHGEF7_chr13_111768038_ENST00000317133_EXOC4_chr7_133580352_ENST00000539845_length(amino acids)=517AA_BP=121
MRRRLTAGRGARRSGPGRTCWAAPSQSPAPAARWARRRRRRRGPRAGPPLRGEGARPSPPASRAAAMNSAEQTVTWLITLGVLESPKKTI
SDPEGFLQASLKDGVVLCRLLERLLPGTIEKSTIIVEKTVQDLLNLMHDLSAYSDQFLNMVCVKLQEYKDTCTAAYRGIVQSEEKLVISA
SWAKDDDISRLLKSLPNWMNMAQPKQLRPKREEEEDFIRAAFGKESEVLIGNLGDKLIPPQDILRDVSDLKALANMHESLEWLASRTKSA
FSNLSTSQMLSPAQDSHTNTDLPPVSEQIMQTLSELAKSFQDMADRCLLVLHLEVRVHCFHYLIPLAKEGNYAIVANVESMDYDPLVVKL
NKDISAIEEAMSASLQQHKFQYIFEGLGHLISCILINGAQYFRRISESGIKKMCRNIFVLQQNLTNITMSREADLDFARQYYEMLYNTAD

--------------------------------------------------------------
>6346_6346_3_ARHGEF7-EXOC4_ARHGEF7_chr13_111768038_ENST00000370623_EXOC4_chr7_133580352_ENST00000253861_length(transcript)=2587nt_BP=165nt
ATGAATTCCGCCGAGCAAACCGTTACGTGGCTCATCACTCTGGGGGTGCTGGAGTCGCCCAAAAAAACCATCTCGGACCCGGAGGGCTTT
CTGCAGGCGTCGCTGAAGGATGGGGTGGTCCTCTGCAGGCTGCTGGAGCGCCTGCTCCCCGGGACCATCGAGAAAAGCACAATCATTGTG
GAGAAGACAGTTCAAGACCTCCTGAACCTGATGCATGACTTGAGTGCATATTCAGATCAATTCCTCAACATGGTGTGCGTGAAGCTCCAG
GAGTACAAGGACACCTGCACTGCAGCTTACAGGGGTATTGTCCAGTCAGAAGAAAAACTTGTCATCAGTGCATCCTGGGCAAAAGATGAT
GATATCAGCAGACTCTTGAAATCTCTACCAAACTGGATGAATATGGCTCAACCCAAACAGCTGAGGCCAAAAAGAGAGGAGGAAGAAGAT
TTCATAAGGGCAGCTTTTGGCAAGGAGTCTGAAGTTCTTATTGGGAACCTGGGTGATAAATTAATCCCTCCACAAGACATCCTTCGTGAC
GTCAGTGACCTCAAAGCCTTGGCCAACATGCATGAAAGCCTGGAATGGTTGGCAAGTCGAACAAAGTCAGCTTTCTCCAATCTTTCTACA
TCCCAGATGCTTTCTCCTGCTCAAGACAGCCACACGAACACGGATCTCCCCCCAGTGTCAGAGCAGATCATGCAGACTCTCAGTGAACTT
GCCAAATCGTTCCAGGATATGGCTGACCGCTGCTTGCTTGTCTTACATCTGGAAGTGAGGGTTCACTGTTTCCACTATCTTATCCCTCTT
GCAAAGGAGGGGAACTATGCCATTGTGGCTAATGTGGAAAGTATGGATTATGACCCCCTGGTGGTCAAGCTCAACAAAGATATCAGCGCC
ATTGAAGAGGCCATGAGCGCCAGCCTTCAGCAGCACAAGTTCCAGTATATCTTCGAAGGCCTGGGCCACCTGATCTCCTGCATCCTCATT
AATGGTGCCCAGTACTTCAGGCGCATCAGTGAGTCTGGCATCAAGAAAATGTGTAGGAACATTTTTGTTCTTCAGCAGAATTTGACCAAC
ATCACCATGTCGCGGGAGGCAGACCTGGACTTTGCAAGGCAGTACTACGAGATGCTTTACAACACAGCTGACGAGCTCCTGAACCTGGTG
GTGGACCAGGGTGTGAAGTACACGGAGCTGGAGTACATCCACGCTCTGACCCTGCTGCACCGCAGCCAGACTGGGGTGGGGGAACTGACC
ACCCAGAACACGAGGCTGCAGAGGCTCAAAGAGATCATCTGCGAGCAGGCTGCCATCAAGCAAGCCACCAAGGACAAGAAGATAACTACC
GTTTAGCAGGGCGTACTGCGGTTGGTGACGGGGGTCCCCTCAGTCACACTCACTTTTTTCCTTGGTATGTTATTGAGTATATTCTGAGCT
TAGTTTTCTCTACAGTGATACTTTAGTGGAGAGGAGGTGTAAGGATTCTTTCTCTCTGGTTTTGGCTTTTCATATAAATGCTAAAGGAAG
GCGACAGTACAGAGTGTTTTGGTTGAACAACTACTTTAATGCAGTCAAATCTAACGGGACTAGGGTGGGATAGGGAGGAAGGTGGTATCA
AATTGTTGGACTCTGAAAAACAAGTGGATGGATTACTAATATTTGATTTATTACTCAATATATATATAATTCCAGCCTTGGAAAGTAGGA
AAGTAGGCTGCTACCTAACTTTTAGTCCCTTCCAAAACCATTTAGTAGGGTTCTATTACATAAACAGTAGGGTTTTTCCTCTCCTGACCT
TATCCGTTTACAGTTCAATGAAATAAGTGTATGTGCATTGCTGTCTGTCTCTATTGCCAAAATCAAATAAATGGCTTCTCAGCTGCTGTT
TACAACAAACTTCCCTAACCAAAACAGAACCTCTAATTTAGGGCTAGGAATAGAAGTCTTTTGATCCCAGTCCCTGGGACAGTTTTGTAT
GCTGTATCTTGTACACAGGTTGTAGGTTGGTTTATTGCCATTTTGTTTTATTTCTGCTGTATAAAAACCAAGAGCCAGACAATTAGACAA
CTATGGAGGAATGAAAGGCAATTCAAACATCTGCTTGATTCCCGCCCCGCCACCCCTAATTTCTGAGAGAATAATGGTTAGAGAACATTG
CATCTCACTTGAAACATCCTTTGGGGGTAAATGATTCTTAGGTGCTCACTTGGTCTGAGCTCAGCTGAATGCAGGGAAGATGGGACAGAG
TGACATTTCTCCTCTGTGCGGCCTCCAGCTGAGCCTGTCTCTGAATTGTTCCCTCCCCCGCAATGTGGGCACTTACCATGTTCCTGGCAC
ACTGGACCTCACCATGTCCCCCGGTCACCAGTCCTCTTGCTGCCCATGGTTCATAGGTCATAGAAGGCAGCAATGCACTGACTGGGCCAC
ATCTTGAAAACTCGTGGAAAGGGAAAGGGGAGGAGATGGGACTTTGACCACACACAGTGATGCCTCACACCCTGAAGGTGGGGGATTTTG

>6346_6346_3_ARHGEF7-EXOC4_ARHGEF7_chr13_111768038_ENST00000370623_EXOC4_chr7_133580352_ENST00000253861_length(amino acids)=451AA_BP=55
MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKSTIIVEKTVQDLLNLMHDLSAYSDQFLNMVCVKLQ
EYKDTCTAAYRGIVQSEEKLVISASWAKDDDISRLLKSLPNWMNMAQPKQLRPKREEEEDFIRAAFGKESEVLIGNLGDKLIPPQDILRD
VSDLKALANMHESLEWLASRTKSAFSNLSTSQMLSPAQDSHTNTDLPPVSEQIMQTLSELAKSFQDMADRCLLVLHLEVRVHCFHYLIPL
AKEGNYAIVANVESMDYDPLVVKLNKDISAIEEAMSASLQQHKFQYIFEGLGHLISCILINGAQYFRRISESGIKKMCRNIFVLQQNLTN
ITMSREADLDFARQYYEMLYNTADELLNLVVDQGVKYTELEYIHALTLLHRSQTGVGELTTQNTRLQRLKEIICEQAAIKQATKDKKITT

--------------------------------------------------------------
>6346_6346_4_ARHGEF7-EXOC4_ARHGEF7_chr13_111768038_ENST00000370623_EXOC4_chr7_133580352_ENST00000539845_length(transcript)=1415nt_BP=165nt
ATGAATTCCGCCGAGCAAACCGTTACGTGGCTCATCACTCTGGGGGTGCTGGAGTCGCCCAAAAAAACCATCTCGGACCCGGAGGGCTTT
CTGCAGGCGTCGCTGAAGGATGGGGTGGTCCTCTGCAGGCTGCTGGAGCGCCTGCTCCCCGGGACCATCGAGAAAAGCACAATCATTGTG
GAGAAGACAGTTCAAGACCTCCTGAACCTGATGCATGACTTGAGTGCATATTCAGATCAATTCCTCAACATGGTGTGCGTGAAGCTCCAG
GAGTACAAGGACACCTGCACTGCAGCTTACAGGGGTATTGTCCAGTCAGAAGAAAAACTTGTCATCAGTGCATCCTGGGCAAAAGATGAT
GATATCAGCAGACTCTTGAAATCTCTACCAAACTGGATGAATATGGCTCAACCCAAACAGCTGAGGCCAAAAAGAGAGGAGGAAGAAGAT
TTCATAAGGGCAGCTTTTGGCAAGGAGTCTGAAGTTCTTATTGGGAACCTGGGTGATAAATTAATCCCTCCACAAGACATCCTTCGTGAC
GTCAGTGACCTCAAAGCCTTGGCCAACATGCATGAAAGCCTGGAATGGTTGGCAAGTCGAACAAAGTCAGCTTTCTCCAATCTTTCTACA
TCCCAGATGCTTTCTCCTGCTCAAGACAGCCACACGAACACGGATCTCCCCCCAGTGTCAGAGCAGATCATGCAGACTCTCAGTGAACTT
GCCAAATCGTTCCAGGATATGGCTGACCGCTGCTTGCTTGTCTTACATCTGGAAGTGAGGGTTCACTGTTTCCACTATCTTATCCCTCTT
GCAAAGGAGGGGAACTATGCCATTGTGGCTAATGTGGAAAGTATGGATTATGACCCCCTGGTGGTCAAGCTCAACAAAGATATCAGCGCC
ATTGAAGAGGCCATGAGCGCCAGCCTTCAGCAGCACAAGTTCCAGTATATCTTCGAAGGCCTGGGCCACCTGATCTCCTGCATCCTCATT
AATGGTGCCCAGTACTTCAGGCGCATCAGTGAGTCTGGCATCAAGAAAATGTGTAGGAACATTTTTGTTCTTCAGCAGAATTTGACCAAC
ATCACCATGTCGCGGGAGGCAGACCTGGACTTTGCAAGGCAGTACTACGAGATGCTTTACAACACAGCTGACGAGCTCCTGAACCTGGTG
GTGGACCAGGGTGTGAAGTACACGGAGCTGGAGTACATCCACGCTCTGACCCTGCTGCACCGCAGCCAGACTGGGGTGGGGGAACTGACC
ACCCAGAACACGAGGCTGCAGAGGCTCAAAGAGATCATCTGCGAGCAGGCTGCCATCAAGCAAGCCACCAAGGACAAGAAGATAACTACC

>6346_6346_4_ARHGEF7-EXOC4_ARHGEF7_chr13_111768038_ENST00000370623_EXOC4_chr7_133580352_ENST00000539845_length(amino acids)=451AA_BP=55
MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKSTIIVEKTVQDLLNLMHDLSAYSDQFLNMVCVKLQ
EYKDTCTAAYRGIVQSEEKLVISASWAKDDDISRLLKSLPNWMNMAQPKQLRPKREEEEDFIRAAFGKESEVLIGNLGDKLIPPQDILRD
VSDLKALANMHESLEWLASRTKSAFSNLSTSQMLSPAQDSHTNTDLPPVSEQIMQTLSELAKSFQDMADRCLLVLHLEVRVHCFHYLIPL
AKEGNYAIVANVESMDYDPLVVKLNKDISAIEEAMSASLQQHKFQYIFEGLGHLISCILINGAQYFRRISESGIKKMCRNIFVLQQNLTN
ITMSREADLDFARQYYEMLYNTADELLNLVVDQGVKYTELEYIHALTLLHRSQTGVGELTTQNTRLQRLKEIICEQAAIKQATKDKKITT

--------------------------------------------------------------
>6346_6346_5_ARHGEF7-EXOC4_ARHGEF7_chr13_111768038_ENST00000375739_EXOC4_chr7_133580352_ENST00000253861_length(transcript)=2837nt_BP=415nt
GCGGCCGAGGCCGGGGGGCGGCGGCGGGCGCCCGCAGGTTCCCGAGCCGCTCCTGAGAAGGCGCCTGACAGCGGGCCGGGGCGCACGGAG
AAGCGGGCCGGGCCGGACCTGCTGGGCCGCGCCGAGCCAATCGCCGGCGCCGGCCGCTCGATGGGCGAGGCGGCGGCGGCGGCGGCGGGG
GCCGCGGGCCGGGCCGCCGCTCCGAGGTGAAGGCGCGCGCCCCTCCCCGCCTGCCTCCCGGGCCGCAGCGATGAATTCCGCCGAGCAAAC
CGTTACGTGGCTCATCACTCTGGGGGTGCTGGAGTCGCCCAAAAAAACCATCTCGGACCCGGAGGGCTTTCTGCAGGCGTCGCTGAAGGA
TGGGGTGGTCCTCTGCAGGCTGCTGGAGCGCCTGCTCCCCGGGACCATCGAGAAAAGCACAATCATTGTGGAGAAGACAGTTCAAGACCT
CCTGAACCTGATGCATGACTTGAGTGCATATTCAGATCAATTCCTCAACATGGTGTGCGTGAAGCTCCAGGAGTACAAGGACACCTGCAC
TGCAGCTTACAGGGGTATTGTCCAGTCAGAAGAAAAACTTGTCATCAGTGCATCCTGGGCAAAAGATGATGATATCAGCAGACTCTTGAA
ATCTCTACCAAACTGGATGAATATGGCTCAACCCAAACAGCTGAGGCCAAAAAGAGAGGAGGAAGAAGATTTCATAAGGGCAGCTTTTGG
CAAGGAGTCTGAAGTTCTTATTGGGAACCTGGGTGATAAATTAATCCCTCCACAAGACATCCTTCGTGACGTCAGTGACCTCAAAGCCTT
GGCCAACATGCATGAAAGCCTGGAATGGTTGGCAAGTCGAACAAAGTCAGCTTTCTCCAATCTTTCTACATCCCAGATGCTTTCTCCTGC
TCAAGACAGCCACACGAACACGGATCTCCCCCCAGTGTCAGAGCAGATCATGCAGACTCTCAGTGAACTTGCCAAATCGTTCCAGGATAT
GGCTGACCGCTGCTTGCTTGTCTTACATCTGGAAGTGAGGGTTCACTGTTTCCACTATCTTATCCCTCTTGCAAAGGAGGGGAACTATGC
CATTGTGGCTAATGTGGAAAGTATGGATTATGACCCCCTGGTGGTCAAGCTCAACAAAGATATCAGCGCCATTGAAGAGGCCATGAGCGC
CAGCCTTCAGCAGCACAAGTTCCAGTATATCTTCGAAGGCCTGGGCCACCTGATCTCCTGCATCCTCATTAATGGTGCCCAGTACTTCAG
GCGCATCAGTGAGTCTGGCATCAAGAAAATGTGTAGGAACATTTTTGTTCTTCAGCAGAATTTGACCAACATCACCATGTCGCGGGAGGC
AGACCTGGACTTTGCAAGGCAGTACTACGAGATGCTTTACAACACAGCTGACGAGCTCCTGAACCTGGTGGTGGACCAGGGTGTGAAGTA
CACGGAGCTGGAGTACATCCACGCTCTGACCCTGCTGCACCGCAGCCAGACTGGGGTGGGGGAACTGACCACCCAGAACACGAGGCTGCA
GAGGCTCAAAGAGATCATCTGCGAGCAGGCTGCCATCAAGCAAGCCACCAAGGACAAGAAGATAACTACCGTTTAGCAGGGCGTACTGCG
GTTGGTGACGGGGGTCCCCTCAGTCACACTCACTTTTTTCCTTGGTATGTTATTGAGTATATTCTGAGCTTAGTTTTCTCTACAGTGATA
CTTTAGTGGAGAGGAGGTGTAAGGATTCTTTCTCTCTGGTTTTGGCTTTTCATATAAATGCTAAAGGAAGGCGACAGTACAGAGTGTTTT
GGTTGAACAACTACTTTAATGCAGTCAAATCTAACGGGACTAGGGTGGGATAGGGAGGAAGGTGGTATCAAATTGTTGGACTCTGAAAAA
CAAGTGGATGGATTACTAATATTTGATTTATTACTCAATATATATATAATTCCAGCCTTGGAAAGTAGGAAAGTAGGCTGCTACCTAACT
TTTAGTCCCTTCCAAAACCATTTAGTAGGGTTCTATTACATAAACAGTAGGGTTTTTCCTCTCCTGACCTTATCCGTTTACAGTTCAATG
AAATAAGTGTATGTGCATTGCTGTCTGTCTCTATTGCCAAAATCAAATAAATGGCTTCTCAGCTGCTGTTTACAACAAACTTCCCTAACC
AAAACAGAACCTCTAATTTAGGGCTAGGAATAGAAGTCTTTTGATCCCAGTCCCTGGGACAGTTTTGTATGCTGTATCTTGTACACAGGT
TGTAGGTTGGTTTATTGCCATTTTGTTTTATTTCTGCTGTATAAAAACCAAGAGCCAGACAATTAGACAACTATGGAGGAATGAAAGGCA
ATTCAAACATCTGCTTGATTCCCGCCCCGCCACCCCTAATTTCTGAGAGAATAATGGTTAGAGAACATTGCATCTCACTTGAAACATCCT
TTGGGGGTAAATGATTCTTAGGTGCTCACTTGGTCTGAGCTCAGCTGAATGCAGGGAAGATGGGACAGAGTGACATTTCTCCTCTGTGCG
GCCTCCAGCTGAGCCTGTCTCTGAATTGTTCCCTCCCCCGCAATGTGGGCACTTACCATGTTCCTGGCACACTGGACCTCACCATGTCCC
CCGGTCACCAGTCCTCTTGCTGCCCATGGTTCATAGGTCATAGAAGGCAGCAATGCACTGACTGGGCCACATCTTGAAAACTCGTGGAAA
GGGAAAGGGGAGGAGATGGGACTTTGACCACACACAGTGATGCCTCACACCCTGAAGGTGGGGGATTTTGTACCTGTTTGTACAACTTTG

>6346_6346_5_ARHGEF7-EXOC4_ARHGEF7_chr13_111768038_ENST00000375739_EXOC4_chr7_133580352_ENST00000253861_length(amino acids)=517AA_BP=121
MRRRLTAGRGARRSGPGRTCWAAPSQSPAPAARWARRRRRRRGPRAGPPLRGEGARPSPPASRAAAMNSAEQTVTWLITLGVLESPKKTI
SDPEGFLQASLKDGVVLCRLLERLLPGTIEKSTIIVEKTVQDLLNLMHDLSAYSDQFLNMVCVKLQEYKDTCTAAYRGIVQSEEKLVISA
SWAKDDDISRLLKSLPNWMNMAQPKQLRPKREEEEDFIRAAFGKESEVLIGNLGDKLIPPQDILRDVSDLKALANMHESLEWLASRTKSA
FSNLSTSQMLSPAQDSHTNTDLPPVSEQIMQTLSELAKSFQDMADRCLLVLHLEVRVHCFHYLIPLAKEGNYAIVANVESMDYDPLVVKL
NKDISAIEEAMSASLQQHKFQYIFEGLGHLISCILINGAQYFRRISESGIKKMCRNIFVLQQNLTNITMSREADLDFARQYYEMLYNTAD

--------------------------------------------------------------
>6346_6346_6_ARHGEF7-EXOC4_ARHGEF7_chr13_111768038_ENST00000375739_EXOC4_chr7_133580352_ENST00000539845_length(transcript)=1665nt_BP=415nt
GCGGCCGAGGCCGGGGGGCGGCGGCGGGCGCCCGCAGGTTCCCGAGCCGCTCCTGAGAAGGCGCCTGACAGCGGGCCGGGGCGCACGGAG
AAGCGGGCCGGGCCGGACCTGCTGGGCCGCGCCGAGCCAATCGCCGGCGCCGGCCGCTCGATGGGCGAGGCGGCGGCGGCGGCGGCGGGG
GCCGCGGGCCGGGCCGCCGCTCCGAGGTGAAGGCGCGCGCCCCTCCCCGCCTGCCTCCCGGGCCGCAGCGATGAATTCCGCCGAGCAAAC
CGTTACGTGGCTCATCACTCTGGGGGTGCTGGAGTCGCCCAAAAAAACCATCTCGGACCCGGAGGGCTTTCTGCAGGCGTCGCTGAAGGA
TGGGGTGGTCCTCTGCAGGCTGCTGGAGCGCCTGCTCCCCGGGACCATCGAGAAAAGCACAATCATTGTGGAGAAGACAGTTCAAGACCT
CCTGAACCTGATGCATGACTTGAGTGCATATTCAGATCAATTCCTCAACATGGTGTGCGTGAAGCTCCAGGAGTACAAGGACACCTGCAC
TGCAGCTTACAGGGGTATTGTCCAGTCAGAAGAAAAACTTGTCATCAGTGCATCCTGGGCAAAAGATGATGATATCAGCAGACTCTTGAA
ATCTCTACCAAACTGGATGAATATGGCTCAACCCAAACAGCTGAGGCCAAAAAGAGAGGAGGAAGAAGATTTCATAAGGGCAGCTTTTGG
CAAGGAGTCTGAAGTTCTTATTGGGAACCTGGGTGATAAATTAATCCCTCCACAAGACATCCTTCGTGACGTCAGTGACCTCAAAGCCTT
GGCCAACATGCATGAAAGCCTGGAATGGTTGGCAAGTCGAACAAAGTCAGCTTTCTCCAATCTTTCTACATCCCAGATGCTTTCTCCTGC
TCAAGACAGCCACACGAACACGGATCTCCCCCCAGTGTCAGAGCAGATCATGCAGACTCTCAGTGAACTTGCCAAATCGTTCCAGGATAT
GGCTGACCGCTGCTTGCTTGTCTTACATCTGGAAGTGAGGGTTCACTGTTTCCACTATCTTATCCCTCTTGCAAAGGAGGGGAACTATGC
CATTGTGGCTAATGTGGAAAGTATGGATTATGACCCCCTGGTGGTCAAGCTCAACAAAGATATCAGCGCCATTGAAGAGGCCATGAGCGC
CAGCCTTCAGCAGCACAAGTTCCAGTATATCTTCGAAGGCCTGGGCCACCTGATCTCCTGCATCCTCATTAATGGTGCCCAGTACTTCAG
GCGCATCAGTGAGTCTGGCATCAAGAAAATGTGTAGGAACATTTTTGTTCTTCAGCAGAATTTGACCAACATCACCATGTCGCGGGAGGC
AGACCTGGACTTTGCAAGGCAGTACTACGAGATGCTTTACAACACAGCTGACGAGCTCCTGAACCTGGTGGTGGACCAGGGTGTGAAGTA
CACGGAGCTGGAGTACATCCACGCTCTGACCCTGCTGCACCGCAGCCAGACTGGGGTGGGGGAACTGACCACCCAGAACACGAGGCTGCA
GAGGCTCAAAGAGATCATCTGCGAGCAGGCTGCCATCAAGCAAGCCACCAAGGACAAGAAGATAACTACCGTTTAGCAGGGCGTACTGCG

>6346_6346_6_ARHGEF7-EXOC4_ARHGEF7_chr13_111768038_ENST00000375739_EXOC4_chr7_133580352_ENST00000539845_length(amino acids)=517AA_BP=121
MRRRLTAGRGARRSGPGRTCWAAPSQSPAPAARWARRRRRRRGPRAGPPLRGEGARPSPPASRAAAMNSAEQTVTWLITLGVLESPKKTI
SDPEGFLQASLKDGVVLCRLLERLLPGTIEKSTIIVEKTVQDLLNLMHDLSAYSDQFLNMVCVKLQEYKDTCTAAYRGIVQSEEKLVISA
SWAKDDDISRLLKSLPNWMNMAQPKQLRPKREEEEDFIRAAFGKESEVLIGNLGDKLIPPQDILRDVSDLKALANMHESLEWLASRTKSA
FSNLSTSQMLSPAQDSHTNTDLPPVSEQIMQTLSELAKSFQDMADRCLLVLHLEVRVHCFHYLIPLAKEGNYAIVANVESMDYDPLVVKL
NKDISAIEEAMSASLQQHKFQYIFEGLGHLISCILINGAQYFRRISESGIKKMCRNIFVLQQNLTNITMSREADLDFARQYYEMLYNTAD

--------------------------------------------------------------
>6346_6346_7_ARHGEF7-EXOC4_ARHGEF7_chr13_111768038_ENST00000375741_EXOC4_chr7_133580352_ENST00000253861_length(transcript)=2837nt_BP=415nt
GCGGCCGAGGCCGGGGGGCGGCGGCGGGCGCCCGCAGGTTCCCGAGCCGCTCCTGAGAAGGCGCCTGACAGCGGGCCGGGGCGCACGGAG
AAGCGGGCCGGGCCGGACCTGCTGGGCCGCGCCGAGCCAATCGCCGGCGCCGGCCGCTCGATGGGCGAGGCGGCGGCGGCGGCGGCGGGG
GCCGCGGGCCGGGCCGCCGCTCCGAGGTGAAGGCGCGCGCCCCTCCCCGCCTGCCTCCCGGGCCGCAGCGATGAATTCCGCCGAGCAAAC
CGTTACGTGGCTCATCACTCTGGGGGTGCTGGAGTCGCCCAAAAAAACCATCTCGGACCCGGAGGGCTTTCTGCAGGCGTCGCTGAAGGA
TGGGGTGGTCCTCTGCAGGCTGCTGGAGCGCCTGCTCCCCGGGACCATCGAGAAAAGCACAATCATTGTGGAGAAGACAGTTCAAGACCT
CCTGAACCTGATGCATGACTTGAGTGCATATTCAGATCAATTCCTCAACATGGTGTGCGTGAAGCTCCAGGAGTACAAGGACACCTGCAC
TGCAGCTTACAGGGGTATTGTCCAGTCAGAAGAAAAACTTGTCATCAGTGCATCCTGGGCAAAAGATGATGATATCAGCAGACTCTTGAA
ATCTCTACCAAACTGGATGAATATGGCTCAACCCAAACAGCTGAGGCCAAAAAGAGAGGAGGAAGAAGATTTCATAAGGGCAGCTTTTGG
CAAGGAGTCTGAAGTTCTTATTGGGAACCTGGGTGATAAATTAATCCCTCCACAAGACATCCTTCGTGACGTCAGTGACCTCAAAGCCTT
GGCCAACATGCATGAAAGCCTGGAATGGTTGGCAAGTCGAACAAAGTCAGCTTTCTCCAATCTTTCTACATCCCAGATGCTTTCTCCTGC
TCAAGACAGCCACACGAACACGGATCTCCCCCCAGTGTCAGAGCAGATCATGCAGACTCTCAGTGAACTTGCCAAATCGTTCCAGGATAT
GGCTGACCGCTGCTTGCTTGTCTTACATCTGGAAGTGAGGGTTCACTGTTTCCACTATCTTATCCCTCTTGCAAAGGAGGGGAACTATGC
CATTGTGGCTAATGTGGAAAGTATGGATTATGACCCCCTGGTGGTCAAGCTCAACAAAGATATCAGCGCCATTGAAGAGGCCATGAGCGC
CAGCCTTCAGCAGCACAAGTTCCAGTATATCTTCGAAGGCCTGGGCCACCTGATCTCCTGCATCCTCATTAATGGTGCCCAGTACTTCAG
GCGCATCAGTGAGTCTGGCATCAAGAAAATGTGTAGGAACATTTTTGTTCTTCAGCAGAATTTGACCAACATCACCATGTCGCGGGAGGC
AGACCTGGACTTTGCAAGGCAGTACTACGAGATGCTTTACAACACAGCTGACGAGCTCCTGAACCTGGTGGTGGACCAGGGTGTGAAGTA
CACGGAGCTGGAGTACATCCACGCTCTGACCCTGCTGCACCGCAGCCAGACTGGGGTGGGGGAACTGACCACCCAGAACACGAGGCTGCA
GAGGCTCAAAGAGATCATCTGCGAGCAGGCTGCCATCAAGCAAGCCACCAAGGACAAGAAGATAACTACCGTTTAGCAGGGCGTACTGCG
GTTGGTGACGGGGGTCCCCTCAGTCACACTCACTTTTTTCCTTGGTATGTTATTGAGTATATTCTGAGCTTAGTTTTCTCTACAGTGATA
CTTTAGTGGAGAGGAGGTGTAAGGATTCTTTCTCTCTGGTTTTGGCTTTTCATATAAATGCTAAAGGAAGGCGACAGTACAGAGTGTTTT
GGTTGAACAACTACTTTAATGCAGTCAAATCTAACGGGACTAGGGTGGGATAGGGAGGAAGGTGGTATCAAATTGTTGGACTCTGAAAAA
CAAGTGGATGGATTACTAATATTTGATTTATTACTCAATATATATATAATTCCAGCCTTGGAAAGTAGGAAAGTAGGCTGCTACCTAACT
TTTAGTCCCTTCCAAAACCATTTAGTAGGGTTCTATTACATAAACAGTAGGGTTTTTCCTCTCCTGACCTTATCCGTTTACAGTTCAATG
AAATAAGTGTATGTGCATTGCTGTCTGTCTCTATTGCCAAAATCAAATAAATGGCTTCTCAGCTGCTGTTTACAACAAACTTCCCTAACC
AAAACAGAACCTCTAATTTAGGGCTAGGAATAGAAGTCTTTTGATCCCAGTCCCTGGGACAGTTTTGTATGCTGTATCTTGTACACAGGT
TGTAGGTTGGTTTATTGCCATTTTGTTTTATTTCTGCTGTATAAAAACCAAGAGCCAGACAATTAGACAACTATGGAGGAATGAAAGGCA
ATTCAAACATCTGCTTGATTCCCGCCCCGCCACCCCTAATTTCTGAGAGAATAATGGTTAGAGAACATTGCATCTCACTTGAAACATCCT
TTGGGGGTAAATGATTCTTAGGTGCTCACTTGGTCTGAGCTCAGCTGAATGCAGGGAAGATGGGACAGAGTGACATTTCTCCTCTGTGCG
GCCTCCAGCTGAGCCTGTCTCTGAATTGTTCCCTCCCCCGCAATGTGGGCACTTACCATGTTCCTGGCACACTGGACCTCACCATGTCCC
CCGGTCACCAGTCCTCTTGCTGCCCATGGTTCATAGGTCATAGAAGGCAGCAATGCACTGACTGGGCCACATCTTGAAAACTCGTGGAAA
GGGAAAGGGGAGGAGATGGGACTTTGACCACACACAGTGATGCCTCACACCCTGAAGGTGGGGGATTTTGTACCTGTTTGTACAACTTTG

>6346_6346_7_ARHGEF7-EXOC4_ARHGEF7_chr13_111768038_ENST00000375741_EXOC4_chr7_133580352_ENST00000253861_length(amino acids)=517AA_BP=121
MRRRLTAGRGARRSGPGRTCWAAPSQSPAPAARWARRRRRRRGPRAGPPLRGEGARPSPPASRAAAMNSAEQTVTWLITLGVLESPKKTI
SDPEGFLQASLKDGVVLCRLLERLLPGTIEKSTIIVEKTVQDLLNLMHDLSAYSDQFLNMVCVKLQEYKDTCTAAYRGIVQSEEKLVISA
SWAKDDDISRLLKSLPNWMNMAQPKQLRPKREEEEDFIRAAFGKESEVLIGNLGDKLIPPQDILRDVSDLKALANMHESLEWLASRTKSA
FSNLSTSQMLSPAQDSHTNTDLPPVSEQIMQTLSELAKSFQDMADRCLLVLHLEVRVHCFHYLIPLAKEGNYAIVANVESMDYDPLVVKL
NKDISAIEEAMSASLQQHKFQYIFEGLGHLISCILINGAQYFRRISESGIKKMCRNIFVLQQNLTNITMSREADLDFARQYYEMLYNTAD

--------------------------------------------------------------
>6346_6346_8_ARHGEF7-EXOC4_ARHGEF7_chr13_111768038_ENST00000375741_EXOC4_chr7_133580352_ENST00000539845_length(transcript)=1665nt_BP=415nt
GCGGCCGAGGCCGGGGGGCGGCGGCGGGCGCCCGCAGGTTCCCGAGCCGCTCCTGAGAAGGCGCCTGACAGCGGGCCGGGGCGCACGGAG
AAGCGGGCCGGGCCGGACCTGCTGGGCCGCGCCGAGCCAATCGCCGGCGCCGGCCGCTCGATGGGCGAGGCGGCGGCGGCGGCGGCGGGG
GCCGCGGGCCGGGCCGCCGCTCCGAGGTGAAGGCGCGCGCCCCTCCCCGCCTGCCTCCCGGGCCGCAGCGATGAATTCCGCCGAGCAAAC
CGTTACGTGGCTCATCACTCTGGGGGTGCTGGAGTCGCCCAAAAAAACCATCTCGGACCCGGAGGGCTTTCTGCAGGCGTCGCTGAAGGA
TGGGGTGGTCCTCTGCAGGCTGCTGGAGCGCCTGCTCCCCGGGACCATCGAGAAAAGCACAATCATTGTGGAGAAGACAGTTCAAGACCT
CCTGAACCTGATGCATGACTTGAGTGCATATTCAGATCAATTCCTCAACATGGTGTGCGTGAAGCTCCAGGAGTACAAGGACACCTGCAC
TGCAGCTTACAGGGGTATTGTCCAGTCAGAAGAAAAACTTGTCATCAGTGCATCCTGGGCAAAAGATGATGATATCAGCAGACTCTTGAA
ATCTCTACCAAACTGGATGAATATGGCTCAACCCAAACAGCTGAGGCCAAAAAGAGAGGAGGAAGAAGATTTCATAAGGGCAGCTTTTGG
CAAGGAGTCTGAAGTTCTTATTGGGAACCTGGGTGATAAATTAATCCCTCCACAAGACATCCTTCGTGACGTCAGTGACCTCAAAGCCTT
GGCCAACATGCATGAAAGCCTGGAATGGTTGGCAAGTCGAACAAAGTCAGCTTTCTCCAATCTTTCTACATCCCAGATGCTTTCTCCTGC
TCAAGACAGCCACACGAACACGGATCTCCCCCCAGTGTCAGAGCAGATCATGCAGACTCTCAGTGAACTTGCCAAATCGTTCCAGGATAT
GGCTGACCGCTGCTTGCTTGTCTTACATCTGGAAGTGAGGGTTCACTGTTTCCACTATCTTATCCCTCTTGCAAAGGAGGGGAACTATGC
CATTGTGGCTAATGTGGAAAGTATGGATTATGACCCCCTGGTGGTCAAGCTCAACAAAGATATCAGCGCCATTGAAGAGGCCATGAGCGC
CAGCCTTCAGCAGCACAAGTTCCAGTATATCTTCGAAGGCCTGGGCCACCTGATCTCCTGCATCCTCATTAATGGTGCCCAGTACTTCAG
GCGCATCAGTGAGTCTGGCATCAAGAAAATGTGTAGGAACATTTTTGTTCTTCAGCAGAATTTGACCAACATCACCATGTCGCGGGAGGC
AGACCTGGACTTTGCAAGGCAGTACTACGAGATGCTTTACAACACAGCTGACGAGCTCCTGAACCTGGTGGTGGACCAGGGTGTGAAGTA
CACGGAGCTGGAGTACATCCACGCTCTGACCCTGCTGCACCGCAGCCAGACTGGGGTGGGGGAACTGACCACCCAGAACACGAGGCTGCA
GAGGCTCAAAGAGATCATCTGCGAGCAGGCTGCCATCAAGCAAGCCACCAAGGACAAGAAGATAACTACCGTTTAGCAGGGCGTACTGCG

>6346_6346_8_ARHGEF7-EXOC4_ARHGEF7_chr13_111768038_ENST00000375741_EXOC4_chr7_133580352_ENST00000539845_length(amino acids)=517AA_BP=121
MRRRLTAGRGARRSGPGRTCWAAPSQSPAPAARWARRRRRRRGPRAGPPLRGEGARPSPPASRAAAMNSAEQTVTWLITLGVLESPKKTI
SDPEGFLQASLKDGVVLCRLLERLLPGTIEKSTIIVEKTVQDLLNLMHDLSAYSDQFLNMVCVKLQEYKDTCTAAYRGIVQSEEKLVISA
SWAKDDDISRLLKSLPNWMNMAQPKQLRPKREEEEDFIRAAFGKESEVLIGNLGDKLIPPQDILRDVSDLKALANMHESLEWLASRTKSA
FSNLSTSQMLSPAQDSHTNTDLPPVSEQIMQTLSELAKSFQDMADRCLLVLHLEVRVHCFHYLIPLAKEGNYAIVANVESMDYDPLVVKL
NKDISAIEEAMSASLQQHKFQYIFEGLGHLISCILINGAQYFRRISESGIKKMCRNIFVLQQNLTNITMSREADLDFARQYYEMLYNTAD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARHGEF7-EXOC4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGEF7-EXOC4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGEF7-EXOC4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource