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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HERC1-DAPK2 (FusionGDB2 ID:HG8925TG23604)

Fusion Gene Summary for HERC1-DAPK2

check button Fusion gene summary
Fusion gene informationFusion gene name: HERC1-DAPK2
Fusion gene ID: hg8925tg23604
HgeneTgene
Gene symbol

HERC1

DAPK2

Gene ID

8925

23604

Gene nameHECT and RLD domain containing E3 ubiquitin protein ligase family member 1death associated protein kinase 2
SynonymsMDFPMR|p532|p619DRP-1|DRP1
Cytomap('HERC1')('DAPK2')

15q22.31

15q22.31

Type of geneprotein-codingprotein-coding
Descriptionprobable E3 ubiquitin-protein ligase HERC1HECT domain and RCC1-like domain-containing protein 1HECT-type E3 ubiquitin transferase HERC1guanine nucleotide exchange factor p532hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHCdeath-associated protein kinase 2DAP kinase 2DAP-kinase-related protein 1 beta isoform
Modification date2020031320200313
UniProtAcc

Q15751

Q9UIK4

Ensembl transtripts involved in fusion geneENST00000443617, ENST00000443617, 
Fusion gene scores* DoF score16 X 17 X 10=27208 X 9 X 8=576
# samples 2213
** MAII scorelog2(22/2720*10)=-3.62803122261304
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/576*10)=-2.14755718841386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: HERC1 [Title/Abstract] AND DAPK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHERC1(64126026)-DAPK2(64231560), # samples:3
HERC1(64126026)-DAPK2(64204396), # samples:3
Anticipated loss of major functional domain due to fusion event.HERC1-DAPK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HERC1-DAPK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HERC1-DAPK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HERC1-DAPK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HERC1-DAPK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
HERC1-DAPK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
HERC1-DAPK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
HERC1-DAPK2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
DAPK2-HERC1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
DAPK2-HERC1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
DAPK2-HERC1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
DAPK2-HERC1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDAPK2

GO:0006468

protein phosphorylation

10376525

TgeneDAPK2

GO:0035556

intracellular signal transduction

10376525


check buttonFusion gene breakpoints across HERC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across DAPK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OR-A5JC-01AHERC1chr15

63956669

-DAPK2chr15

64275953

-
ChimerDB4BLCATCGA-DK-A3X2-01AHERC1chr15

64126026

-DAPK2chr15

64231560

-
ChimerDB4BRCATCGA-D8-A1JK-01AHERC1chr15

64126026

-DAPK2chr15

64204396

-
ChimerDB4LIHCTCGA-NI-A8LF-01AHERC1chr15

64126026

-DAPK2chr15

64332466

-
ChimerDB4STADTCGA-VQ-A8E2-01AHERC1chr15

63988323

-DAPK2chr15

64263760

-


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Fusion Gene ORF analysis for HERC1-DAPK2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000443617ENST00000558482HERC1chr15

63956669

-DAPK2chr15

64275953

-
5CDS-5UTRENST00000443617ENST00000558482HERC1chr15

63988323

-DAPK2chr15

64263760

-
5UTR-3CDSENST00000443617ENST00000261891HERC1chr15

64126026

-DAPK2chr15

64231560

-
5UTR-3CDSENST00000443617ENST00000261891HERC1chr15

64126026

-DAPK2chr15

64204396

-
5UTR-3CDSENST00000443617ENST00000261891HERC1chr15

64126026

-DAPK2chr15

64332466

-
5UTR-3CDSENST00000443617ENST00000457488HERC1chr15

64126026

-DAPK2chr15

64231560

-
5UTR-3CDSENST00000443617ENST00000457488HERC1chr15

64126026

-DAPK2chr15

64204396

-
5UTR-3CDSENST00000443617ENST00000558069HERC1chr15

64126026

-DAPK2chr15

64231560

-
5UTR-5UTRENST00000443617ENST00000457488HERC1chr15

64126026

-DAPK2chr15

64332466

-
5UTR-5UTRENST00000443617ENST00000558069HERC1chr15

64126026

-DAPK2chr15

64332466

-
5UTR-5UTRENST00000443617ENST00000558482HERC1chr15

64126026

-DAPK2chr15

64231560

-
5UTR-5UTRENST00000443617ENST00000558482HERC1chr15

64126026

-DAPK2chr15

64332466

-
5UTR-intronENST00000443617ENST00000558069HERC1chr15

64126026

-DAPK2chr15

64204396

-
5UTR-intronENST00000443617ENST00000558482HERC1chr15

64126026

-DAPK2chr15

64204396

-
Frame-shiftENST00000443617ENST00000261891HERC1chr15

63956669

-DAPK2chr15

64275953

-
Frame-shiftENST00000443617ENST00000457488HERC1chr15

63956669

-DAPK2chr15

64275953

-
Frame-shiftENST00000443617ENST00000558069HERC1chr15

63956669

-DAPK2chr15

64275953

-
In-frameENST00000443617ENST00000261891HERC1chr15

63988323

-DAPK2chr15

64263760

-
In-frameENST00000443617ENST00000457488HERC1chr15

63988323

-DAPK2chr15

64263760

-
In-frameENST00000443617ENST00000558069HERC1chr15

63988323

-DAPK2chr15

64263760

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000443617HERC1chr1563988323-ENST00000261891DAPK2chr1564263760-749252098852621724
ENST00000443617HERC1chr1563988323-ENST00000457488DAPK2chr1564263760-660552098852621724
ENST00000443617HERC1chr1563988323-ENST00000558069DAPK2chr1564263760-636252098852621724

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000443617ENST00000261891HERC1chr1563988323-DAPK2chr1564263760-0.0016341950.9983658
ENST00000443617ENST00000457488HERC1chr1563988323-DAPK2chr1564263760-0.0021505880.99784946
ENST00000443617ENST00000558069HERC1chr1563988323-DAPK2chr1564263760-0.002639980.99736005

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Fusion Genomic Features for HERC1-DAPK2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for HERC1-DAPK2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:64126026/chr15:64231560)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HERC1

Q15751

DAPK2

Q9UIK4

FUNCTION: Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}.FUNCTION: Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (PubMed:17347302). Regulates granulocytic motility by controlling cell spreading and polarization (PubMed:24163421). {ECO:0000269|PubMed:17347302, ECO:0000269|PubMed:24163421, ECO:0000269|PubMed:26047703}.; FUNCTION: Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27781349_137817074862.0Compositional biasNote=Glu-rich
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-2778371_42017074862.0RepeatNote=RCC1 1
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-2778421_47517074862.0RepeatNote=RCC1 2
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-2778476_52817074862.0RepeatNote=RCC1 3
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-2778529_57817074862.0RepeatNote=RCC1 4
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-2778580_63117074862.0RepeatNote=RCC1 5
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-2778633_68217074862.0RepeatNote=RCC1 6
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-2778683_73517074862.0RepeatNote=RCC1 7
TgeneDAPK2chr15:63988323chr15:64263760ENST00000261891111277_344104371.0RegionNote=Calmodulin-binding
TgeneDAPK2chr15:63988323chr15:64263760ENST00000261891111292_301104371.0RegionAutoinhibitory domain
TgeneDAPK2chr15:63988323chr15:64263760ENST00000457488212277_344104371.0RegionNote=Calmodulin-binding
TgeneDAPK2chr15:63988323chr15:64263760ENST00000457488212292_301104371.0RegionAutoinhibitory domain
TgeneDAPK2chr15:63988323chr15:64263760ENST00000558069210277_344104489.0RegionNote=Calmodulin-binding
TgeneDAPK2chr15:63988323chr15:64263760ENST00000558069210292_301104489.0RegionAutoinhibitory domain

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27782002_219317074862.0DomainB30.2/SPRY
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27784501_484817074862.0DomainHECT
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27783426_346517074862.0RepeatNote=WD 1
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27783484_352217074862.0RepeatNote=WD 2
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27783524_357217074862.0RepeatNote=WD 3
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27783580_361917074862.0RepeatNote=WD 4
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27783624_366317074862.0RepeatNote=WD 5
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27783667_371317074862.0RepeatNote=WD 6
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27783745_378417074862.0RepeatNote=WD 7
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27783996_404417074862.0RepeatNote=RCC1 8
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27784046_409917074862.0RepeatNote=RCC1 9
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27784101_415117074862.0RepeatNote=RCC1 10
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27784153_420317074862.0RepeatNote=RCC1 11
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27784205_425617074862.0RepeatNote=RCC1 12
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27784258_430817074862.0RepeatNote=RCC1 13
HgeneHERC1chr15:63988323chr15:64263760ENST00000443617-27784310_436017074862.0RepeatNote=RCC1 14
TgeneDAPK2chr15:63988323chr15:64263760ENST0000026189111123_285104371.0DomainProtein kinase
TgeneDAPK2chr15:63988323chr15:64263760ENST0000045748821223_285104371.0DomainProtein kinase
TgeneDAPK2chr15:63988323chr15:64263760ENST0000055806921023_285104489.0DomainProtein kinase
TgeneDAPK2chr15:63988323chr15:64263760ENST0000026189111129_37104371.0Nucleotide bindingATP
TgeneDAPK2chr15:63988323chr15:64263760ENST0000045748821229_37104371.0Nucleotide bindingATP
TgeneDAPK2chr15:63988323chr15:64263760ENST0000055806921029_37104489.0Nucleotide bindingATP


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Fusion Gene Sequence for HERC1-DAPK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>36131_36131_1_HERC1-DAPK2_HERC1_chr15_63988323_ENST00000443617_DAPK2_chr15_64263760_ENST00000261891_length(transcript)=7492nt_BP=5209nt
CCTCTGCGGAGCCGGGCTCGGGTCGCCGGAGCCGCGCCCCACCCCGCCAGCTCCAGAGCCACGACTAATGGCTGAAGGATAAATCAACAT
GGCAACTATGATTCCACCAGTGAAGCTGAAATGGCTTGAACACTTGAACAGCTCCTGGATTACAGAGGACAGTGAATCTATTGCTACAAG
AGAGGGAGTTGCTGTTCTGTATTCTAAACTGGTTAGCAATAAGGAAGTAGTACCTTTGCCCCAACAAGTTTTATGCCTCAAAGGACCACA
GTTGCCAGACTTTGAACGTGAGTCTCTTTCAAGTGATGAGCAGGACCACTATTTGGATGCCCTTCTTAGCAGCCAGCTAGCATTGGCAAA
GATGGTATGTTCAGATTCCCCATTTGCCGGGGCACTTAGAAAACGACTGCTTGTACTCCAGCGTGTCTTTTATGCACTTTCTAATAAATA
CCATGACAAAGGCAAGGTGAAGCAGCAGCAGCATTCTCCGGAGAGCAGTTCTGGTTCAGCAGATGTCCATTCTGTTAGTGAACGCCCCCG
GTCAAGCACTGATGCACTTATAGAAATGGGTGTTCGAACTGGTCTAAGTTTATTATTTGCGCTTCTAAGACAAAGTTGGATGATGCCTGT
GTCAGGACCTGGTCTCAGTCTTTGCAACGATGTCATTCATACTGCAATTGAAGTTGTGAGCTCTTTGCCACCATTATCATTAGCAAATGA
AAGCAAGATTCCTCCTATGGGCTTGGACTGCTTATCGCAAGTAACAACATTTCTTAAAGGAGTCACTATTCCTAATTCTGGGGCAGACAC
TTTAGGTCGTAGATTAGCTTCTGAGTTGCTGCTTGGTTTGGCAGCTCAACGAGGCTCATTGCGATATCTTCTTGAATGGATAGAAATGGC
TTTGGGGGCTTCGGCAGTTGTACACACCATGGAGAAAGGCAAACTACTCTCAAGCCAGGAAGGAATGATCAGCTTTGACTGCTTTATGAC
CATATTAATGCAGATGAGGCGTTCTTTGGGTTCATCTGCTGATCGGAGTCAGTGGAGAGAACCAACCAGAACATCGGATGGCTTGTGCTC
CCTTTACGAGGCAGCATTATGTCTCTTTGAAGAGGTTTGCAGAATGGCTTCTGATTATTCGAGAACATGTGCTAGCCCAGATAGCATTCA
GACTGGTGATGCTCCCATTGTCTCCGAAACCTGTGAGGTTTATGTTTGGGGGAGCAATAGCAGCCATCAGTTGGTAGAAGGTACACAGGA
GAAAATACTGCAACCCAAACTGGCTCCTAGTTTCTCTGATGCACAGACCATTGAAGCTGGACAGTACTGCACTTTTGTCATTTCTACGGA
TGGCTCTGTTAGAGCTTGCGGGAAAGGCAGCTATGGGAGACTGGGCCTTGGAGACTCCAATAATCAGTCAACTTTAAAAAAGTTAACATT
CGAGCCTCACAGATCCATTAAAAAGGTTTCATCTTCTAAAGGATCTGATGGTCACACTTTAGCCTTTACGACAGAAGGAGAAGTCTTCAG
TTGGGGAGATGGTGATTATGGGAAACTGGGGCATGGAAATAGTTCAACACAGAAATATCCCAAGCTTATTCAGGGACCTCTACAAGGAAA
GGTAGTTGTTTGTGTGTCAGCTGGATACAGACATAGTGCTGCTGTCACAGAGGATGGGGAATTATACACATGGGGTGAAGGAGACTTTGG
AAGATTAGGTCATGGTGACAGCAATAGTCGTAACATTCCAACATTAGTAAAAGACATCAGCAATGTAGGAGAGGTTTCTTGTGGCAGTTC
ACATACTATTGCTCTGTCTAAAGATGGGAGAACTGTATGGTCTTTTGGAGGAGGAGACAATGGTAAACTTGGTCATGGTGATACCAACAG
AGTGTATAAACCTAAAGTTATTGAAGCTTTACAAGGAATGTTCATTCGCAAAGTTTGTGCTGGGAGCCAGTCTTCACTTGCTTTGACATC
AACAGGGCAGGTCTATGCTTGGGGCTGTGGAGCTTGTCTAGGTTGTGGTTCTTCAGAAGCTACTGCTTTGAGACCCAAGCTTATTGAAGA
ACTGGCTGCCACAAGAATAGTTGATGTTTCTATTGGAGACAGTCATTGTTTGGCTCTTTCTCATGATAATGAAGTTTATGCCTGGGGCAA
TAACTCAATGGGGCAATGTGGTCAGGGAAATTCCACAGGTCCTATTACTAAACCAAAGAAAGTGAGTGGCTTAGATGGCATAGCTATTCA
GCAGATTTCGGCTGGAACATCACATAGTCTGGCATGGACTGCTCTTCCTAGGGACAGACAAGTTGTTGCATGGCACCGACCTTATTGTGT
AGATCTTGAAGAGAGTACCTTCTCACACCTGCGTTCTTTTCTTGAGAGATACTGTGATAAAATAAACAGTGAGATTCCCCCACTCCCTTT
CCCTTCATCAAGAGAACACCACAGTTTTCTCAAGCTGTGCCTGAAGCTACTTTCAAATCACCTTGCTCTTGCACTTGCGGGAGGGGTAGC
TACCAGCATTCTCGGGAGGCAGGCAGGTCCACTTCGAAATTTGCTCTTCAGACTGATGGACTCAACTGTCCCAGATGAAATCCAAGAGGT
GGTAATTGAAACTTTATCAGTGGGAGCAACCATGCTGTTACCTCCATTACGAGAACGGATGGAATTACTTCATTCTCTTTTACCTCAAGG
ACCTGATAGATGGGAAAGCTTATCTAAAGGACAGAGAATGCAACTGGATATCATCCTGACAAGTTTGCAAGATCATACCCACGTAGCCTC
CCTACTTGGCTATAGTTCACCCTCTGATGCTGCTGACCTATCTTCTGTGTGTACTGGCTACGGAAATCTGTCAGATCAACCTTACGGCAC
TCAGAGCTGCCATCCAGATACCCACCTGGCTGAAATTTTGATGAAGACCCTCTTAAGAAATTTAGGATTTTATACAGATCAAGCATTTGG
AGAGCTAGAAAAGAATAGTGATAAATTTCTACTTGGAACATCATCATCAGAAAACAGTCAGCCTGCTCATCTTCATGAACTGCTATGTTC
ACTACAGAAACAGCTGCTGGCATTTTGCCATATCAATAACATTAGTGAGAACTCAAGCAGTGTGGCATTGCTTCATAAACATCTTCAGCT
TTTGTTGCCTCATGCCACAGATATTTATTCACGTTCTGCAAATTTGCTCAAAGAAAGTCCTTGGAATGGCAGTGTTGGAGAAAAATTAAG
AGATGTGATATACGTCTCAGCTGCTGGCAGTATGCTCTGCCAGATTGTTAACTCCCTGCTGTTACTCCCTGTGTCAGTGGCTCGGCCTTT
ATTGAGTTACCTCCTCGACTTGTTGCCACCTCTTGATTGCCTTAATAGACTCCTGCCAGCTGCTGATCTTTTAGAAGACCAGGAGTTACA
GTGGCCTCTTCATGGAGGGCCAGAACTAATTGATCCTGCTGGTCTGCCATTACCTCAGCCAGCTCAGTCCTGGGTATGGCTTGTGGATCT
AGAAAGAACAATTGCTCTCCTTATTGGGCGGTGTCTTGGTGGCATGCTTCAGGGCTCCCCTGTGTCTCCAGAGGAACAGGACACTGCATA
TTGGATGAAAACGCCACTGTTCAGTGACGGTGTAGAAATGGACACTCCTCAATTGGATAAATGTATGAGTTGCCTGTTAGAAGTAGCACT
TTCTGGAAATGAAGAACAGAAGCCTTTTGATTATAAATTGCGGCCTGAAATTGCTGTCTATGTAGACTTGGCATTGGGTTGTTCTAAAGA
GCCTGCCCGAAGCCTTTGGATCAGCATGCAGGACTATGCTGTTAGTAAAGATTGGGACAGTGCAACTTTAAGTAATGAGTCACTCTTGGA
CACTGTGTCTAGATTTGTTCTTGCAGCTCTTCTGAAACACACAAATTTACTTAGTCAAGCATGTGGAGAAAGCCGATATCAACCTGGTAA
ACACTTATCAGAAGTGTACCGTTGTGTATACAAAGTTCGAAGTCGTTTACTTGCTTGCAAGAACCTTGAACTTATTCAAACAAGGTCATC
ATCACGGGACAGATGGATATCAGAAAACCAGGACTCTGCAGATGTTGATCCTCAGGAGCATTCATTTACTCGAACTATTGATGAAGAAGC
TGAAATGGAAGAACAGGCTGAGAGAGACCGGGAAGAGGGGCATCCGGAGCCAGAGGATGAAGAGGAGGAACGGGAACATGAAGTGATGAC
AGCTGGCAAAATCTTTCAGTGTTTCCTCTCAGCCCGTGAAGTAGCTCGTAGCCGAGACCGAGATAGAATGAACAGTGGGGCAGGGTCTGG
GGCTCGAGCTGATGATCCACCTCCTCAGTCTCAGCAAGAGCGAAGGGTCAGCACAGACCTTCCTGAGGGTCAGGATGTGTACACTGCTGC
ATGCAACTCCGTGATCCATCGGTGTGCCCTGTTAATATTAGGAGTAAGTCCTGTGATAGATGAGCTTCAGAAGCGAAGAGAAGAAGGACA
GTTGCAGCAACCTTCAACAAGTGCCTCTGAAGGGGGTGGACTTATGACCAGGAGTGAAAGTCTTACTGCAGAGAGCCGGCTAGTCCACAC
AAGCCCAAATTATAGACTGATCAAATCGAGGAGTGAATCTGATTTGTCTCAGCCTGAATCAGATGAAGAGGGTTACGCACTGAGTGGCAG
ACGAAATGTTGATTTGGATTTGGCAGCATCTCACAGAAAGAGAGGTCCTATGCACAGTCAATTGGAATCCCTGAGTGACTCTTGGGCTCG
CCTGAAACATAGCAGAGACTGGTTATGCAACTCCTCCTATTCCTTTGAGTCAGATTTTGATCTTACCAAGTCTTTGGGAGTTCACACTTT
GATTGAAAATGTTGTAAGCTTTGTGAGTGGAGATGTGGGGAATGCCCCAGGTTTTAAAGAGCCAGAGGAAAGTATGTCTACAAGTCCCCA
GGCCTCCATCATTGCAATGGAACAGCAGCAGTTAAGGGCAGAACTTCGTTTAGAGGCACTTCATCAGATCCTCGTTCTATTGTCTGGGAT
GGAAGAAAAAGGTAGCATCTCACTGGCAGGAAGCAGATTGAGTTCAGGCTTCCAGTCCTCCACACTACTCACGTCTGTGAGGCTGCAGTT
CCTAGCAGGGTGTTTTGGTTTAGGCACTGTTGGACACACAGGAGGCAAGGGAGAGAGTGGCCGATTGCATCACTATCAGAGTGTCTGGAG
GAGAGCTCTTCGATTTCCTGGCCCAGAAGGAGTCACTGAGTGAGGAGGAGGCCACCAGCTTCATTAAGCAGATCCTGGATGGGGTGAACT
ACCTTCACACAAAGAAAATTGCTCACTTTGATCTCAAGCCAGAAAACATTATGTTGTTAGACAAGAATATTCCCATTCCACACATCAAGC
TGATTGACTTTGGTCTGGCTCACGAAATAGAAGATGGAGTTGAATTTAAGAATATTTTTGGGACGCCGGAATTTGTTGCTCCAGAAATTG
TGAACTACGAGCCCCTGGGTCTGGAGGCTGACATGTGGAGCATAGGCGTCATCACCTACATCCTCTTAAGTGGAGCATCCCCTTTCCTGG
GAGACACGAAGCAGGAAACACTGGCAAATATCACAGCAGTGAGTTACGACTTTGATGAGGAATTCTTCAGCCAGACGAGCGAGCTGGCCA
AGGACTTTATTCGGAAGCTTCTGGTTAAAGAGACCCGGAAACGGCTCACAATCCAAGAGGCTCTCAGACACCCCTGGATCACGCCGGTGG
ACAACCAGCAAGCCATGGTGCGCAGGGAGTCTGTGGTCAATCTGGAGAACTTCAGGAAGCAGTATGTCCGCAGGCGGTGGAAGCTTTCCT
TCAGCATCGTGTCCCTGTGCAACCACCTCACCCGCTCGCTGATGAAGAAGGTGCACCTGAGGCCGGATGAGGACCTGAGGAACTGTGAGA
GTGACACTGAGGAGGACATCGCCAGGAGGAAAGCCCTCCACCCACGGAGGAGGAGCAGCACCTCCTAACTGGCCTGACCTGCAGTGGCCG
CCAGGGAGGTCTGGGCCCAGCGGGGCTCCCTTCTGTGCAGACTTTTGGACCCAGCTCAGCACCAGCACCCGGGCGTCCTGAGCACTTTGC
AAGAGAGATGGGCCCAAGGAATTCAGAAGAGCTTGCAGGCAAGCCAGGAGACCCTGGGAGCTGTGGCTGTCTTCTGTGGAGGAGGCTCCA
GCATTCCCAAAGCTCTTAATTCTCCATAAAATGGGCTTTCCTCTGTCTGCCATCCTCAGAGTCTGGGGTGGGAGTGTGGACTTAGGAAAA
CAATATAAAGGACATCCTCATCATCACGGGGTGAAGGTCAGACTAAGGCAGCCTTCTTCACAGGCTGAGGGGGTTCAGAACCAGCCTGGC
CAAAAATTACACCAGAGAGACAGAGTCCTCCCCATTGGGAACAGGGTGATTGAGGAAAGTGAACCTTGGGTGTGAGGGACCAATCCTGTG
ACCTCCCAGAACCATGGAAGCCAGGACGTCAGGCTGACCAACACCTCAGACCTTCTGAAGCAGCCCATTGCTGGCCCGCCATGTTGTAAT
TTTGCTCATTTTTATTAAACTTCTGGTTTACCTGATGCTTGGCTTCTTTTAGGGCTACCCCCATCTCATTTCCTTTAGCCCGTGTGCCTG
TAACTCTGAGGGGGGGCACCCAGTGGGGTGCTGAGTGGGCAGAATCTCAGAAGGTCCTCCTGAACCGTCCGCGCAGGCCTGCAGTGGGCC
TGCCTCCTCCTTGCTTCCCTAACAGGAAGGTGTCCAGTTCAAGAGAACCCACCCAGAGACTGGGAGTGGTGGCTCACGCCTATAATCCCT
GCGCTTTGGCAGTCCGAGGCAGGGGAATTGCTTGAACTCAGGAGTTGGAGACCAGCCTGGGCAACATGGCAAAACGCAGTCTGTACAAAA
AATACAAAAAATTAGCCAGGTGTAGGGGTAGGCACCTGGCATCCCAGCTACTCCAGGGGCTGAGGTGACAGCATTGCTTAAGCCCAGAAG
GTCGAGGCTGCAGTGAGCTGAGATCACGCCACTGCACTCCAGTCTGGGTGACAGAGAGAGACCATATCCAAAAAAAAAAAAAGTTGCCAG
AGACGAGTATGCCCATGCTCCCTCTACCTCACTGCCACCACTCCTGCTGTTAGGAGCTGAGTGTGTCTCCCTAAAATTTCTATGTTGAAG
TCTTAACCCTTGGTACCACAGAATATCACTGTATTTGGAGATGGGGTCTTTAGAAAGGCACTTAAATTAAAATGAGCTCACTGATATGGG
CCCCGATGCAATATAATTGGTGTCCTTATAAGAAGGGGAGGTTAGGACACGCAGGAAAGACCACATGAAGGCCCAGGAGTGGGAGGGGGA
ATAGCCATCGACAAACTAAGGGGGCCTCAGAGGAAACCAACCCTGCTGACACCTCAATCTTAGACTCTGGCCTCAAAAATTGTAAGAAAA

>36131_36131_1_HERC1-DAPK2_HERC1_chr15_63988323_ENST00000443617_DAPK2_chr15_64263760_ENST00000261891_length(amino acids)=1724AA_BP=1706
MATMIPPVKLKWLEHLNSSWITEDSESIATREGVAVLYSKLVSNKEVVPLPQQVLCLKGPQLPDFERESLSSDEQDHYLDALLSSQLALA
KMVCSDSPFAGALRKRLLVLQRVFYALSNKYHDKGKVKQQQHSPESSSGSADVHSVSERPRSSTDALIEMGVRTGLSLLFALLRQSWMMP
VSGPGLSLCNDVIHTAIEVVSSLPPLSLANESKIPPMGLDCLSQVTTFLKGVTIPNSGADTLGRRLASELLLGLAAQRGSLRYLLEWIEM
ALGASAVVHTMEKGKLLSSQEGMISFDCFMTILMQMRRSLGSSADRSQWREPTRTSDGLCSLYEAALCLFEEVCRMASDYSRTCASPDSI
QTGDAPIVSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLT
FEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDF
GRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALT
STGQVYAWGCGACLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAI
QQISAGTSHSLAWTALPRDRQVVAWHRPYCVDLEESTFSHLRSFLERYCDKINSEIPPLPFPSSREHHSFLKLCLKLLSNHLALALAGGV
ATSILGRQAGPLRNLLFRLMDSTVPDEIQEVVIETLSVGATMLLPPLRERMELLHSLLPQGPDRWESLSKGQRMQLDIILTSLQDHTHVA
SLLGYSSPSDAADLSSVCTGYGNLSDQPYGTQSCHPDTHLAEILMKTLLRNLGFYTDQAFGELEKNSDKFLLGTSSSENSQPAHLHELLC
SLQKQLLAFCHINNISENSSSVALLHKHLQLLLPHATDIYSRSANLLKESPWNGSVGEKLRDVIYVSAAGSMLCQIVNSLLLLPVSVARP
LLSYLLDLLPPLDCLNRLLPAADLLEDQELQWPLHGGPELIDPAGLPLPQPAQSWVWLVDLERTIALLIGRCLGGMLQGSPVSPEEQDTA
YWMKTPLFSDGVEMDTPQLDKCMSCLLEVALSGNEEQKPFDYKLRPEIAVYVDLALGCSKEPARSLWISMQDYAVSKDWDSATLSNESLL
DTVSRFVLAALLKHTNLLSQACGESRYQPGKHLSEVYRCVYKVRSRLLACKNLELIQTRSSSRDRWISENQDSADVDPQEHSFTRTIDEE
AEMEEQAERDREEGHPEPEDEEEEREHEVMTAGKIFQCFLSAREVARSRDRDRMNSGAGSGARADDPPPQSQQERRVSTDLPEGQDVYTA
ACNSVIHRCALLILGVSPVIDELQKRREEGQLQQPSTSASEGGGLMTRSESLTAESRLVHTSPNYRLIKSRSESDLSQPESDEEGYALSG
RRNVDLDLAASHRKRGPMHSQLESLSDSWARLKHSRDWLCNSSYSFESDFDLTKSLGVHTLIENVVSFVSGDVGNAPGFKEPEESMSTSP
QASIIAMEQQQLRAELRLEALHQILVLLSGMEEKGSISLAGSRLSSGFQSSTLLTSVRLQFLAGCFGLGTVGHTGGKGESGRLHHYQSVW

--------------------------------------------------------------
>36131_36131_2_HERC1-DAPK2_HERC1_chr15_63988323_ENST00000443617_DAPK2_chr15_64263760_ENST00000457488_length(transcript)=6605nt_BP=5209nt
CCTCTGCGGAGCCGGGCTCGGGTCGCCGGAGCCGCGCCCCACCCCGCCAGCTCCAGAGCCACGACTAATGGCTGAAGGATAAATCAACAT
GGCAACTATGATTCCACCAGTGAAGCTGAAATGGCTTGAACACTTGAACAGCTCCTGGATTACAGAGGACAGTGAATCTATTGCTACAAG
AGAGGGAGTTGCTGTTCTGTATTCTAAACTGGTTAGCAATAAGGAAGTAGTACCTTTGCCCCAACAAGTTTTATGCCTCAAAGGACCACA
GTTGCCAGACTTTGAACGTGAGTCTCTTTCAAGTGATGAGCAGGACCACTATTTGGATGCCCTTCTTAGCAGCCAGCTAGCATTGGCAAA
GATGGTATGTTCAGATTCCCCATTTGCCGGGGCACTTAGAAAACGACTGCTTGTACTCCAGCGTGTCTTTTATGCACTTTCTAATAAATA
CCATGACAAAGGCAAGGTGAAGCAGCAGCAGCATTCTCCGGAGAGCAGTTCTGGTTCAGCAGATGTCCATTCTGTTAGTGAACGCCCCCG
GTCAAGCACTGATGCACTTATAGAAATGGGTGTTCGAACTGGTCTAAGTTTATTATTTGCGCTTCTAAGACAAAGTTGGATGATGCCTGT
GTCAGGACCTGGTCTCAGTCTTTGCAACGATGTCATTCATACTGCAATTGAAGTTGTGAGCTCTTTGCCACCATTATCATTAGCAAATGA
AAGCAAGATTCCTCCTATGGGCTTGGACTGCTTATCGCAAGTAACAACATTTCTTAAAGGAGTCACTATTCCTAATTCTGGGGCAGACAC
TTTAGGTCGTAGATTAGCTTCTGAGTTGCTGCTTGGTTTGGCAGCTCAACGAGGCTCATTGCGATATCTTCTTGAATGGATAGAAATGGC
TTTGGGGGCTTCGGCAGTTGTACACACCATGGAGAAAGGCAAACTACTCTCAAGCCAGGAAGGAATGATCAGCTTTGACTGCTTTATGAC
CATATTAATGCAGATGAGGCGTTCTTTGGGTTCATCTGCTGATCGGAGTCAGTGGAGAGAACCAACCAGAACATCGGATGGCTTGTGCTC
CCTTTACGAGGCAGCATTATGTCTCTTTGAAGAGGTTTGCAGAATGGCTTCTGATTATTCGAGAACATGTGCTAGCCCAGATAGCATTCA
GACTGGTGATGCTCCCATTGTCTCCGAAACCTGTGAGGTTTATGTTTGGGGGAGCAATAGCAGCCATCAGTTGGTAGAAGGTACACAGGA
GAAAATACTGCAACCCAAACTGGCTCCTAGTTTCTCTGATGCACAGACCATTGAAGCTGGACAGTACTGCACTTTTGTCATTTCTACGGA
TGGCTCTGTTAGAGCTTGCGGGAAAGGCAGCTATGGGAGACTGGGCCTTGGAGACTCCAATAATCAGTCAACTTTAAAAAAGTTAACATT
CGAGCCTCACAGATCCATTAAAAAGGTTTCATCTTCTAAAGGATCTGATGGTCACACTTTAGCCTTTACGACAGAAGGAGAAGTCTTCAG
TTGGGGAGATGGTGATTATGGGAAACTGGGGCATGGAAATAGTTCAACACAGAAATATCCCAAGCTTATTCAGGGACCTCTACAAGGAAA
GGTAGTTGTTTGTGTGTCAGCTGGATACAGACATAGTGCTGCTGTCACAGAGGATGGGGAATTATACACATGGGGTGAAGGAGACTTTGG
AAGATTAGGTCATGGTGACAGCAATAGTCGTAACATTCCAACATTAGTAAAAGACATCAGCAATGTAGGAGAGGTTTCTTGTGGCAGTTC
ACATACTATTGCTCTGTCTAAAGATGGGAGAACTGTATGGTCTTTTGGAGGAGGAGACAATGGTAAACTTGGTCATGGTGATACCAACAG
AGTGTATAAACCTAAAGTTATTGAAGCTTTACAAGGAATGTTCATTCGCAAAGTTTGTGCTGGGAGCCAGTCTTCACTTGCTTTGACATC
AACAGGGCAGGTCTATGCTTGGGGCTGTGGAGCTTGTCTAGGTTGTGGTTCTTCAGAAGCTACTGCTTTGAGACCCAAGCTTATTGAAGA
ACTGGCTGCCACAAGAATAGTTGATGTTTCTATTGGAGACAGTCATTGTTTGGCTCTTTCTCATGATAATGAAGTTTATGCCTGGGGCAA
TAACTCAATGGGGCAATGTGGTCAGGGAAATTCCACAGGTCCTATTACTAAACCAAAGAAAGTGAGTGGCTTAGATGGCATAGCTATTCA
GCAGATTTCGGCTGGAACATCACATAGTCTGGCATGGACTGCTCTTCCTAGGGACAGACAAGTTGTTGCATGGCACCGACCTTATTGTGT
AGATCTTGAAGAGAGTACCTTCTCACACCTGCGTTCTTTTCTTGAGAGATACTGTGATAAAATAAACAGTGAGATTCCCCCACTCCCTTT
CCCTTCATCAAGAGAACACCACAGTTTTCTCAAGCTGTGCCTGAAGCTACTTTCAAATCACCTTGCTCTTGCACTTGCGGGAGGGGTAGC
TACCAGCATTCTCGGGAGGCAGGCAGGTCCACTTCGAAATTTGCTCTTCAGACTGATGGACTCAACTGTCCCAGATGAAATCCAAGAGGT
GGTAATTGAAACTTTATCAGTGGGAGCAACCATGCTGTTACCTCCATTACGAGAACGGATGGAATTACTTCATTCTCTTTTACCTCAAGG
ACCTGATAGATGGGAAAGCTTATCTAAAGGACAGAGAATGCAACTGGATATCATCCTGACAAGTTTGCAAGATCATACCCACGTAGCCTC
CCTACTTGGCTATAGTTCACCCTCTGATGCTGCTGACCTATCTTCTGTGTGTACTGGCTACGGAAATCTGTCAGATCAACCTTACGGCAC
TCAGAGCTGCCATCCAGATACCCACCTGGCTGAAATTTTGATGAAGACCCTCTTAAGAAATTTAGGATTTTATACAGATCAAGCATTTGG
AGAGCTAGAAAAGAATAGTGATAAATTTCTACTTGGAACATCATCATCAGAAAACAGTCAGCCTGCTCATCTTCATGAACTGCTATGTTC
ACTACAGAAACAGCTGCTGGCATTTTGCCATATCAATAACATTAGTGAGAACTCAAGCAGTGTGGCATTGCTTCATAAACATCTTCAGCT
TTTGTTGCCTCATGCCACAGATATTTATTCACGTTCTGCAAATTTGCTCAAAGAAAGTCCTTGGAATGGCAGTGTTGGAGAAAAATTAAG
AGATGTGATATACGTCTCAGCTGCTGGCAGTATGCTCTGCCAGATTGTTAACTCCCTGCTGTTACTCCCTGTGTCAGTGGCTCGGCCTTT
ATTGAGTTACCTCCTCGACTTGTTGCCACCTCTTGATTGCCTTAATAGACTCCTGCCAGCTGCTGATCTTTTAGAAGACCAGGAGTTACA
GTGGCCTCTTCATGGAGGGCCAGAACTAATTGATCCTGCTGGTCTGCCATTACCTCAGCCAGCTCAGTCCTGGGTATGGCTTGTGGATCT
AGAAAGAACAATTGCTCTCCTTATTGGGCGGTGTCTTGGTGGCATGCTTCAGGGCTCCCCTGTGTCTCCAGAGGAACAGGACACTGCATA
TTGGATGAAAACGCCACTGTTCAGTGACGGTGTAGAAATGGACACTCCTCAATTGGATAAATGTATGAGTTGCCTGTTAGAAGTAGCACT
TTCTGGAAATGAAGAACAGAAGCCTTTTGATTATAAATTGCGGCCTGAAATTGCTGTCTATGTAGACTTGGCATTGGGTTGTTCTAAAGA
GCCTGCCCGAAGCCTTTGGATCAGCATGCAGGACTATGCTGTTAGTAAAGATTGGGACAGTGCAACTTTAAGTAATGAGTCACTCTTGGA
CACTGTGTCTAGATTTGTTCTTGCAGCTCTTCTGAAACACACAAATTTACTTAGTCAAGCATGTGGAGAAAGCCGATATCAACCTGGTAA
ACACTTATCAGAAGTGTACCGTTGTGTATACAAAGTTCGAAGTCGTTTACTTGCTTGCAAGAACCTTGAACTTATTCAAACAAGGTCATC
ATCACGGGACAGATGGATATCAGAAAACCAGGACTCTGCAGATGTTGATCCTCAGGAGCATTCATTTACTCGAACTATTGATGAAGAAGC
TGAAATGGAAGAACAGGCTGAGAGAGACCGGGAAGAGGGGCATCCGGAGCCAGAGGATGAAGAGGAGGAACGGGAACATGAAGTGATGAC
AGCTGGCAAAATCTTTCAGTGTTTCCTCTCAGCCCGTGAAGTAGCTCGTAGCCGAGACCGAGATAGAATGAACAGTGGGGCAGGGTCTGG
GGCTCGAGCTGATGATCCACCTCCTCAGTCTCAGCAAGAGCGAAGGGTCAGCACAGACCTTCCTGAGGGTCAGGATGTGTACACTGCTGC
ATGCAACTCCGTGATCCATCGGTGTGCCCTGTTAATATTAGGAGTAAGTCCTGTGATAGATGAGCTTCAGAAGCGAAGAGAAGAAGGACA
GTTGCAGCAACCTTCAACAAGTGCCTCTGAAGGGGGTGGACTTATGACCAGGAGTGAAAGTCTTACTGCAGAGAGCCGGCTAGTCCACAC
AAGCCCAAATTATAGACTGATCAAATCGAGGAGTGAATCTGATTTGTCTCAGCCTGAATCAGATGAAGAGGGTTACGCACTGAGTGGCAG
ACGAAATGTTGATTTGGATTTGGCAGCATCTCACAGAAAGAGAGGTCCTATGCACAGTCAATTGGAATCCCTGAGTGACTCTTGGGCTCG
CCTGAAACATAGCAGAGACTGGTTATGCAACTCCTCCTATTCCTTTGAGTCAGATTTTGATCTTACCAAGTCTTTGGGAGTTCACACTTT
GATTGAAAATGTTGTAAGCTTTGTGAGTGGAGATGTGGGGAATGCCCCAGGTTTTAAAGAGCCAGAGGAAAGTATGTCTACAAGTCCCCA
GGCCTCCATCATTGCAATGGAACAGCAGCAGTTAAGGGCAGAACTTCGTTTAGAGGCACTTCATCAGATCCTCGTTCTATTGTCTGGGAT
GGAAGAAAAAGGTAGCATCTCACTGGCAGGAAGCAGATTGAGTTCAGGCTTCCAGTCCTCCACACTACTCACGTCTGTGAGGCTGCAGTT
CCTAGCAGGGTGTTTTGGTTTAGGCACTGTTGGACACACAGGAGGCAAGGGAGAGAGTGGCCGATTGCATCACTATCAGAGTGTCTGGAG
GAGAGCTCTTCGATTTCCTGGCCCAGAAGGAGTCACTGAGTGAGGAGGAGGCCACCAGCTTCATTAAGCAGATCCTGGATGGGGTGAACT
ACCTTCACACAAAGAAAATTGCTCACTTTGATCTCAAGCCAGAAAACATTATGTTGTTAGACAAGAATATTCCCATTCCACACATCAAGC
TGATTGACTTTGGTCTGGCTCACGAAATAGAAGATGGAGTTGAATTTAAGAATATTTTTGGGACGCCGGAATTTGTTGCTCCAGAAATTG
TGAACTACGAGCCCCTGGGTCTGGAGGCTGACATGTGGAGCATAGGCGTCATCACCTACATCCTCTTAAGTGGAGCATCCCCTTTCCTGG
GAGACACGAAGCAGGAAACACTGGCAAATATCACAGCAGTGAGTTACGACTTTGATGAGGAATTCTTCAGCCAGACGAGCGAGCTGGCCA
AGGACTTTATTCGGAAGCTTCTGGTTAAAGAGACCCGGAAACGGCTCACAATCCAAGAGGCTCTCAGACACCCCTGGATCACGCCGGTGG
ACAACCAGCAAGCCATGGTGCGCAGGGAGTCTGTGGTCAATCTGGAGAACTTCAGGAAGCAGTATGTCCGCAGGCGGTGGAAGCTTTCCT
TCAGCATCGTGTCCCTGTGCAACCACCTCACCCGCTCGCTGATGAAGAAGGTGCACCTGAGGCCGGATGAGGACCTGAGGAACTGTGAGA
GTGACACTGAGGAGGACATCGCCAGGAGGAAAGCCCTCCACCCACGGAGGAGGAGCAGCACCTCCTAACTGGCCTGACCTGCAGTGGCCG
CCAGGGAGGTCTGGGCCCAGCGGGGCTCCCTTCTGTGCAGACTTTTGGACCCAGCTCAGCACCAGCACCCGGGCGTCCTGAGCACTTTGC
AAGAGAGATGGGCCCAAGGAATTCAGAAGAGCTTGCAGGCAAGCCAGGAGACCCTGGGAGCTGTGGCTGTCTTCTGTGGAGGAGGCTCCA
GCATTCCCAAAGCTCTTAATTCTCCATAAAATGGGCTTTCCTCTGTCTGCCATCCTCAGAGTCTGGGGTGGGAGTGTGGACTTAGGAAAA
CAATATAAAGGACATCCTCATCATCACGGGGTGAAGGTCAGACTAAGGCAGCCTTCTTCACAGGCTGAGGGGGTTCAGAACCAGCCTGGC
CAAAAATTACACCAGAGAGACAGAGTCCTCCCCATTGGGAACAGGGTGATTGAGGAAAGTGAACCTTGGGTGTGAGGGACCAATCCTGTG
ACCTCCCAGAACCATGGAAGCCAGGACGTCAGGCTGACCAACACCTCAGACCTTCTGAAGCAGCCCATTGCTGGCCCGCCATGTTGTAAT

>36131_36131_2_HERC1-DAPK2_HERC1_chr15_63988323_ENST00000443617_DAPK2_chr15_64263760_ENST00000457488_length(amino acids)=1724AA_BP=1706
MATMIPPVKLKWLEHLNSSWITEDSESIATREGVAVLYSKLVSNKEVVPLPQQVLCLKGPQLPDFERESLSSDEQDHYLDALLSSQLALA
KMVCSDSPFAGALRKRLLVLQRVFYALSNKYHDKGKVKQQQHSPESSSGSADVHSVSERPRSSTDALIEMGVRTGLSLLFALLRQSWMMP
VSGPGLSLCNDVIHTAIEVVSSLPPLSLANESKIPPMGLDCLSQVTTFLKGVTIPNSGADTLGRRLASELLLGLAAQRGSLRYLLEWIEM
ALGASAVVHTMEKGKLLSSQEGMISFDCFMTILMQMRRSLGSSADRSQWREPTRTSDGLCSLYEAALCLFEEVCRMASDYSRTCASPDSI
QTGDAPIVSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLT
FEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDF
GRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALT
STGQVYAWGCGACLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAI
QQISAGTSHSLAWTALPRDRQVVAWHRPYCVDLEESTFSHLRSFLERYCDKINSEIPPLPFPSSREHHSFLKLCLKLLSNHLALALAGGV
ATSILGRQAGPLRNLLFRLMDSTVPDEIQEVVIETLSVGATMLLPPLRERMELLHSLLPQGPDRWESLSKGQRMQLDIILTSLQDHTHVA
SLLGYSSPSDAADLSSVCTGYGNLSDQPYGTQSCHPDTHLAEILMKTLLRNLGFYTDQAFGELEKNSDKFLLGTSSSENSQPAHLHELLC
SLQKQLLAFCHINNISENSSSVALLHKHLQLLLPHATDIYSRSANLLKESPWNGSVGEKLRDVIYVSAAGSMLCQIVNSLLLLPVSVARP
LLSYLLDLLPPLDCLNRLLPAADLLEDQELQWPLHGGPELIDPAGLPLPQPAQSWVWLVDLERTIALLIGRCLGGMLQGSPVSPEEQDTA
YWMKTPLFSDGVEMDTPQLDKCMSCLLEVALSGNEEQKPFDYKLRPEIAVYVDLALGCSKEPARSLWISMQDYAVSKDWDSATLSNESLL
DTVSRFVLAALLKHTNLLSQACGESRYQPGKHLSEVYRCVYKVRSRLLACKNLELIQTRSSSRDRWISENQDSADVDPQEHSFTRTIDEE
AEMEEQAERDREEGHPEPEDEEEEREHEVMTAGKIFQCFLSAREVARSRDRDRMNSGAGSGARADDPPPQSQQERRVSTDLPEGQDVYTA
ACNSVIHRCALLILGVSPVIDELQKRREEGQLQQPSTSASEGGGLMTRSESLTAESRLVHTSPNYRLIKSRSESDLSQPESDEEGYALSG
RRNVDLDLAASHRKRGPMHSQLESLSDSWARLKHSRDWLCNSSYSFESDFDLTKSLGVHTLIENVVSFVSGDVGNAPGFKEPEESMSTSP
QASIIAMEQQQLRAELRLEALHQILVLLSGMEEKGSISLAGSRLSSGFQSSTLLTSVRLQFLAGCFGLGTVGHTGGKGESGRLHHYQSVW

--------------------------------------------------------------
>36131_36131_3_HERC1-DAPK2_HERC1_chr15_63988323_ENST00000443617_DAPK2_chr15_64263760_ENST00000558069_length(transcript)=6362nt_BP=5209nt
CCTCTGCGGAGCCGGGCTCGGGTCGCCGGAGCCGCGCCCCACCCCGCCAGCTCCAGAGCCACGACTAATGGCTGAAGGATAAATCAACAT
GGCAACTATGATTCCACCAGTGAAGCTGAAATGGCTTGAACACTTGAACAGCTCCTGGATTACAGAGGACAGTGAATCTATTGCTACAAG
AGAGGGAGTTGCTGTTCTGTATTCTAAACTGGTTAGCAATAAGGAAGTAGTACCTTTGCCCCAACAAGTTTTATGCCTCAAAGGACCACA
GTTGCCAGACTTTGAACGTGAGTCTCTTTCAAGTGATGAGCAGGACCACTATTTGGATGCCCTTCTTAGCAGCCAGCTAGCATTGGCAAA
GATGGTATGTTCAGATTCCCCATTTGCCGGGGCACTTAGAAAACGACTGCTTGTACTCCAGCGTGTCTTTTATGCACTTTCTAATAAATA
CCATGACAAAGGCAAGGTGAAGCAGCAGCAGCATTCTCCGGAGAGCAGTTCTGGTTCAGCAGATGTCCATTCTGTTAGTGAACGCCCCCG
GTCAAGCACTGATGCACTTATAGAAATGGGTGTTCGAACTGGTCTAAGTTTATTATTTGCGCTTCTAAGACAAAGTTGGATGATGCCTGT
GTCAGGACCTGGTCTCAGTCTTTGCAACGATGTCATTCATACTGCAATTGAAGTTGTGAGCTCTTTGCCACCATTATCATTAGCAAATGA
AAGCAAGATTCCTCCTATGGGCTTGGACTGCTTATCGCAAGTAACAACATTTCTTAAAGGAGTCACTATTCCTAATTCTGGGGCAGACAC
TTTAGGTCGTAGATTAGCTTCTGAGTTGCTGCTTGGTTTGGCAGCTCAACGAGGCTCATTGCGATATCTTCTTGAATGGATAGAAATGGC
TTTGGGGGCTTCGGCAGTTGTACACACCATGGAGAAAGGCAAACTACTCTCAAGCCAGGAAGGAATGATCAGCTTTGACTGCTTTATGAC
CATATTAATGCAGATGAGGCGTTCTTTGGGTTCATCTGCTGATCGGAGTCAGTGGAGAGAACCAACCAGAACATCGGATGGCTTGTGCTC
CCTTTACGAGGCAGCATTATGTCTCTTTGAAGAGGTTTGCAGAATGGCTTCTGATTATTCGAGAACATGTGCTAGCCCAGATAGCATTCA
GACTGGTGATGCTCCCATTGTCTCCGAAACCTGTGAGGTTTATGTTTGGGGGAGCAATAGCAGCCATCAGTTGGTAGAAGGTACACAGGA
GAAAATACTGCAACCCAAACTGGCTCCTAGTTTCTCTGATGCACAGACCATTGAAGCTGGACAGTACTGCACTTTTGTCATTTCTACGGA
TGGCTCTGTTAGAGCTTGCGGGAAAGGCAGCTATGGGAGACTGGGCCTTGGAGACTCCAATAATCAGTCAACTTTAAAAAAGTTAACATT
CGAGCCTCACAGATCCATTAAAAAGGTTTCATCTTCTAAAGGATCTGATGGTCACACTTTAGCCTTTACGACAGAAGGAGAAGTCTTCAG
TTGGGGAGATGGTGATTATGGGAAACTGGGGCATGGAAATAGTTCAACACAGAAATATCCCAAGCTTATTCAGGGACCTCTACAAGGAAA
GGTAGTTGTTTGTGTGTCAGCTGGATACAGACATAGTGCTGCTGTCACAGAGGATGGGGAATTATACACATGGGGTGAAGGAGACTTTGG
AAGATTAGGTCATGGTGACAGCAATAGTCGTAACATTCCAACATTAGTAAAAGACATCAGCAATGTAGGAGAGGTTTCTTGTGGCAGTTC
ACATACTATTGCTCTGTCTAAAGATGGGAGAACTGTATGGTCTTTTGGAGGAGGAGACAATGGTAAACTTGGTCATGGTGATACCAACAG
AGTGTATAAACCTAAAGTTATTGAAGCTTTACAAGGAATGTTCATTCGCAAAGTTTGTGCTGGGAGCCAGTCTTCACTTGCTTTGACATC
AACAGGGCAGGTCTATGCTTGGGGCTGTGGAGCTTGTCTAGGTTGTGGTTCTTCAGAAGCTACTGCTTTGAGACCCAAGCTTATTGAAGA
ACTGGCTGCCACAAGAATAGTTGATGTTTCTATTGGAGACAGTCATTGTTTGGCTCTTTCTCATGATAATGAAGTTTATGCCTGGGGCAA
TAACTCAATGGGGCAATGTGGTCAGGGAAATTCCACAGGTCCTATTACTAAACCAAAGAAAGTGAGTGGCTTAGATGGCATAGCTATTCA
GCAGATTTCGGCTGGAACATCACATAGTCTGGCATGGACTGCTCTTCCTAGGGACAGACAAGTTGTTGCATGGCACCGACCTTATTGTGT
AGATCTTGAAGAGAGTACCTTCTCACACCTGCGTTCTTTTCTTGAGAGATACTGTGATAAAATAAACAGTGAGATTCCCCCACTCCCTTT
CCCTTCATCAAGAGAACACCACAGTTTTCTCAAGCTGTGCCTGAAGCTACTTTCAAATCACCTTGCTCTTGCACTTGCGGGAGGGGTAGC
TACCAGCATTCTCGGGAGGCAGGCAGGTCCACTTCGAAATTTGCTCTTCAGACTGATGGACTCAACTGTCCCAGATGAAATCCAAGAGGT
GGTAATTGAAACTTTATCAGTGGGAGCAACCATGCTGTTACCTCCATTACGAGAACGGATGGAATTACTTCATTCTCTTTTACCTCAAGG
ACCTGATAGATGGGAAAGCTTATCTAAAGGACAGAGAATGCAACTGGATATCATCCTGACAAGTTTGCAAGATCATACCCACGTAGCCTC
CCTACTTGGCTATAGTTCACCCTCTGATGCTGCTGACCTATCTTCTGTGTGTACTGGCTACGGAAATCTGTCAGATCAACCTTACGGCAC
TCAGAGCTGCCATCCAGATACCCACCTGGCTGAAATTTTGATGAAGACCCTCTTAAGAAATTTAGGATTTTATACAGATCAAGCATTTGG
AGAGCTAGAAAAGAATAGTGATAAATTTCTACTTGGAACATCATCATCAGAAAACAGTCAGCCTGCTCATCTTCATGAACTGCTATGTTC
ACTACAGAAACAGCTGCTGGCATTTTGCCATATCAATAACATTAGTGAGAACTCAAGCAGTGTGGCATTGCTTCATAAACATCTTCAGCT
TTTGTTGCCTCATGCCACAGATATTTATTCACGTTCTGCAAATTTGCTCAAAGAAAGTCCTTGGAATGGCAGTGTTGGAGAAAAATTAAG
AGATGTGATATACGTCTCAGCTGCTGGCAGTATGCTCTGCCAGATTGTTAACTCCCTGCTGTTACTCCCTGTGTCAGTGGCTCGGCCTTT
ATTGAGTTACCTCCTCGACTTGTTGCCACCTCTTGATTGCCTTAATAGACTCCTGCCAGCTGCTGATCTTTTAGAAGACCAGGAGTTACA
GTGGCCTCTTCATGGAGGGCCAGAACTAATTGATCCTGCTGGTCTGCCATTACCTCAGCCAGCTCAGTCCTGGGTATGGCTTGTGGATCT
AGAAAGAACAATTGCTCTCCTTATTGGGCGGTGTCTTGGTGGCATGCTTCAGGGCTCCCCTGTGTCTCCAGAGGAACAGGACACTGCATA
TTGGATGAAAACGCCACTGTTCAGTGACGGTGTAGAAATGGACACTCCTCAATTGGATAAATGTATGAGTTGCCTGTTAGAAGTAGCACT
TTCTGGAAATGAAGAACAGAAGCCTTTTGATTATAAATTGCGGCCTGAAATTGCTGTCTATGTAGACTTGGCATTGGGTTGTTCTAAAGA
GCCTGCCCGAAGCCTTTGGATCAGCATGCAGGACTATGCTGTTAGTAAAGATTGGGACAGTGCAACTTTAAGTAATGAGTCACTCTTGGA
CACTGTGTCTAGATTTGTTCTTGCAGCTCTTCTGAAACACACAAATTTACTTAGTCAAGCATGTGGAGAAAGCCGATATCAACCTGGTAA
ACACTTATCAGAAGTGTACCGTTGTGTATACAAAGTTCGAAGTCGTTTACTTGCTTGCAAGAACCTTGAACTTATTCAAACAAGGTCATC
ATCACGGGACAGATGGATATCAGAAAACCAGGACTCTGCAGATGTTGATCCTCAGGAGCATTCATTTACTCGAACTATTGATGAAGAAGC
TGAAATGGAAGAACAGGCTGAGAGAGACCGGGAAGAGGGGCATCCGGAGCCAGAGGATGAAGAGGAGGAACGGGAACATGAAGTGATGAC
AGCTGGCAAAATCTTTCAGTGTTTCCTCTCAGCCCGTGAAGTAGCTCGTAGCCGAGACCGAGATAGAATGAACAGTGGGGCAGGGTCTGG
GGCTCGAGCTGATGATCCACCTCCTCAGTCTCAGCAAGAGCGAAGGGTCAGCACAGACCTTCCTGAGGGTCAGGATGTGTACACTGCTGC
ATGCAACTCCGTGATCCATCGGTGTGCCCTGTTAATATTAGGAGTAAGTCCTGTGATAGATGAGCTTCAGAAGCGAAGAGAAGAAGGACA
GTTGCAGCAACCTTCAACAAGTGCCTCTGAAGGGGGTGGACTTATGACCAGGAGTGAAAGTCTTACTGCAGAGAGCCGGCTAGTCCACAC
AAGCCCAAATTATAGACTGATCAAATCGAGGAGTGAATCTGATTTGTCTCAGCCTGAATCAGATGAAGAGGGTTACGCACTGAGTGGCAG
ACGAAATGTTGATTTGGATTTGGCAGCATCTCACAGAAAGAGAGGTCCTATGCACAGTCAATTGGAATCCCTGAGTGACTCTTGGGCTCG
CCTGAAACATAGCAGAGACTGGTTATGCAACTCCTCCTATTCCTTTGAGTCAGATTTTGATCTTACCAAGTCTTTGGGAGTTCACACTTT
GATTGAAAATGTTGTAAGCTTTGTGAGTGGAGATGTGGGGAATGCCCCAGGTTTTAAAGAGCCAGAGGAAAGTATGTCTACAAGTCCCCA
GGCCTCCATCATTGCAATGGAACAGCAGCAGTTAAGGGCAGAACTTCGTTTAGAGGCACTTCATCAGATCCTCGTTCTATTGTCTGGGAT
GGAAGAAAAAGGTAGCATCTCACTGGCAGGAAGCAGATTGAGTTCAGGCTTCCAGTCCTCCACACTACTCACGTCTGTGAGGCTGCAGTT
CCTAGCAGGGTGTTTTGGTTTAGGCACTGTTGGACACACAGGAGGCAAGGGAGAGAGTGGCCGATTGCATCACTATCAGAGTGTCTGGAG
GAGAGCTCTTCGATTTCCTGGCCCAGAAGGAGTCACTGAGTGAGGAGGAGGCCACCAGCTTCATTAAGCAGATCCTGGATGGGGTGAACT
ACCTTCACACAAAGAAAATTGCTCACTTTGATCTCAAGCCAGAAAACATTATGTTGTTAGACAAGAATATTCCCATTCCACACATCAAGC
TGATTGACTTTGGTCTGGCTCACGAAATAGAAGATGGAGTTGAATTTAAGAATATTTTTGGGACGCCGGAATTTGTTGCTCCAGAAATTG
TGAACTACGAGCCCCTGGGTCTGGAGGCTGACATGTGGAGCATAGGCGTCATCACCTACATCCTCTTAAGTGGAGCATCCCCTTTCCTGG
GAGACACGAAGCAGGAAACACTGGCAAATATCACAGCAGTGAGTTACGACTTTGATGAGGAATTCTTCAGCCAGACGAGCGAGCTGGCCA
AGGACTTTATTCGGAAGCTTCTGGTTAAAGAGACCCGGAAACGGCTCACAATCCAAGAGGCTCTCAGACACCCCTGGATCACGTCAAAAG
GAGAAGGCAGAGCCCCTGAACAGCGGAAGACAGAGCCCACCCAGCTGAAGACCAAGCACCTGAGAGAGTACACTCTCAAATGCCACTCAA
GCATGCCTCCCAACAACTCCTATGTCAACTTCGAGCGTTTTGCCTGTGTGGTGGAAGACGTGGCTCGGGTCGACCTGGGATGCCGTGCCC
TGGTGGAGGCCCACGATACCATCCAGGACGATGTGGAGGCCCTGGTCTCCATCTTCAATGAGAAGGAAGCTTGGTACCGAGAGGAGAATG
AGAGCGCCCGGCATGACCTGTCCCAGCTCAGGTATGAGTTCCGCAAGGTGGAGTCATTGAAGAAGCTGCTGCGAGAAGACATCCAGGCCA
CGGGATGTAGCCTCGGAAGCATGGCCAGGAAACTGGACCATCTGCAAGCCCAGTTTGAGATTCTGAGGCAGGAGCTCTCCGCAGACCTGC
AGTGGATTCAGGAGCTGGTGGGCAGCTTCCAGCTGGAGAGTGGGAGCTCTGAGGGCCTGGGCTCCACATTCTACCAGGACACCAGTGAAT

>36131_36131_3_HERC1-DAPK2_HERC1_chr15_63988323_ENST00000443617_DAPK2_chr15_64263760_ENST00000558069_length(amino acids)=1724AA_BP=1706
MATMIPPVKLKWLEHLNSSWITEDSESIATREGVAVLYSKLVSNKEVVPLPQQVLCLKGPQLPDFERESLSSDEQDHYLDALLSSQLALA
KMVCSDSPFAGALRKRLLVLQRVFYALSNKYHDKGKVKQQQHSPESSSGSADVHSVSERPRSSTDALIEMGVRTGLSLLFALLRQSWMMP
VSGPGLSLCNDVIHTAIEVVSSLPPLSLANESKIPPMGLDCLSQVTTFLKGVTIPNSGADTLGRRLASELLLGLAAQRGSLRYLLEWIEM
ALGASAVVHTMEKGKLLSSQEGMISFDCFMTILMQMRRSLGSSADRSQWREPTRTSDGLCSLYEAALCLFEEVCRMASDYSRTCASPDSI
QTGDAPIVSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLT
FEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDF
GRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALT
STGQVYAWGCGACLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAI
QQISAGTSHSLAWTALPRDRQVVAWHRPYCVDLEESTFSHLRSFLERYCDKINSEIPPLPFPSSREHHSFLKLCLKLLSNHLALALAGGV
ATSILGRQAGPLRNLLFRLMDSTVPDEIQEVVIETLSVGATMLLPPLRERMELLHSLLPQGPDRWESLSKGQRMQLDIILTSLQDHTHVA
SLLGYSSPSDAADLSSVCTGYGNLSDQPYGTQSCHPDTHLAEILMKTLLRNLGFYTDQAFGELEKNSDKFLLGTSSSENSQPAHLHELLC
SLQKQLLAFCHINNISENSSSVALLHKHLQLLLPHATDIYSRSANLLKESPWNGSVGEKLRDVIYVSAAGSMLCQIVNSLLLLPVSVARP
LLSYLLDLLPPLDCLNRLLPAADLLEDQELQWPLHGGPELIDPAGLPLPQPAQSWVWLVDLERTIALLIGRCLGGMLQGSPVSPEEQDTA
YWMKTPLFSDGVEMDTPQLDKCMSCLLEVALSGNEEQKPFDYKLRPEIAVYVDLALGCSKEPARSLWISMQDYAVSKDWDSATLSNESLL
DTVSRFVLAALLKHTNLLSQACGESRYQPGKHLSEVYRCVYKVRSRLLACKNLELIQTRSSSRDRWISENQDSADVDPQEHSFTRTIDEE
AEMEEQAERDREEGHPEPEDEEEEREHEVMTAGKIFQCFLSAREVARSRDRDRMNSGAGSGARADDPPPQSQQERRVSTDLPEGQDVYTA
ACNSVIHRCALLILGVSPVIDELQKRREEGQLQQPSTSASEGGGLMTRSESLTAESRLVHTSPNYRLIKSRSESDLSQPESDEEGYALSG
RRNVDLDLAASHRKRGPMHSQLESLSDSWARLKHSRDWLCNSSYSFESDFDLTKSLGVHTLIENVVSFVSGDVGNAPGFKEPEESMSTSP
QASIIAMEQQQLRAELRLEALHQILVLLSGMEEKGSISLAGSRLSSGFQSSTLLTSVRLQFLAGCFGLGTVGHTGGKGESGRLHHYQSVW

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Fusion Gene PPI Analysis for HERC1-DAPK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HERC1-DAPK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneDAPK2Q9UIK4DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational

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Related Diseases for HERC1-DAPK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHERC1C4310766MACROCEPHALY, DYSMORPHIC FACIES, AND PSYCHOMOTOR RETARDATION3CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneHERC1C0004238Atrial Fibrillation1CTD_human
HgeneHERC1C0235480Paroxysmal atrial fibrillation1CTD_human
HgeneHERC1C2585653Persistent atrial fibrillation1CTD_human
HgeneHERC1C3468561familial atrial fibrillation1CTD_human
TgeneC0019209Hepatomegaly1CTD_human
TgeneC0023487Acute Promyelocytic Leukemia1CTD_human