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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HERC1-PCLAF (FusionGDB2 ID:HG8925TG9768)

Fusion Gene Summary for HERC1-PCLAF

check button Fusion gene summary
Fusion gene informationFusion gene name: HERC1-PCLAF
Fusion gene ID: hg8925tg9768
HgeneTgene
Gene symbol

HERC1

PCLAF

Gene ID

8925

9768

Gene nameHECT and RLD domain containing E3 ubiquitin protein ligase family member 1PCNA clamp associated factor
SynonymsMDFPMR|p532|p619KIAA0101|L5|NS5ATP9|OEATC|OEATC-1|OEATC1|PAF|PAF15|p15(PAF)|p15/PAF|p15PAF
Cytomap('HERC1','HERC1')('KIAA0101','PCLAF')

15q22.31

15q22.31

Type of geneprotein-codingprotein-coding
Descriptionprobable E3 ubiquitin-protein ligase HERC1HECT domain and RCC1-like domain-containing protein 1HECT-type E3 ubiquitin transferase HERC1guanine nucleotide exchange factor p532hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHCPCNA-associated factorHCV NS5A-transactivated protein 9PCNA-associated factor of 15 kDahepatitis C virus NS5A-transactivated protein 9overexpressed in anaplastic thyroid carcinoma 1
Modification date2020031320200313
UniProtAcc

Q15751

.
Ensembl transtripts involved in fusion geneENST00000443617, 
Fusion gene scores* DoF score16 X 17 X 10=27202 X 2 X 2=8
# samples 223
** MAII scorelog2(22/2720*10)=-3.62803122261304
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/8*10)=1.90689059560852
Context

PubMed: HERC1 [Title/Abstract] AND PCLAF [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHERC1(63970044)-KIAA0101(64658274), # samples:2
HERC1(64045157)-KIAA0101(64658274), # samples:2
HERC1(64045157)-PCLAF(64658274), # samples:1
HERC1(63970044)-PCLAF(64658274), # samples:1
HERC1(64056295)-PCLAF(64673237), # samples:1
Anticipated loss of major functional domain due to fusion event.HERC1-KIAA0101 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HERC1-KIAA0101 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HERC1-KIAA0101 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HERC1-KIAA0101 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HERC1-KIAA0101 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePCLAF

GO:0006260

DNA replication

23000965

TgenePCLAF

GO:0006974

cellular response to DNA damage stimulus

21628590|23000965

TgenePCLAF

GO:0009411

response to UV

23000965


check buttonFusion gene breakpoints across HERC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PCLAF (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AQ-A54N-01AHERC1chr15

64045157

-KIAA0101chr15

64658274

-
ChimerDB4BRCATCGA-LL-A5YN-01AHERC1chr15

63970044

-KIAA0101chr15

64658274

-
ChimerDB4BRCATCGA-AQ-A54N-01AHERC1chr15

64045157

-PCLAFchr15

64658274

-
ChimerDB4BRCATCGA-LL-A5YN-01AHERC1chr15

63970044

-PCLAFchr15

64658274

-
ChimerDB4LIHCTCGA-CC-A7II-01AHERC1chr15

64056295

-PCLAFchr15

64673237

-


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Fusion Gene ORF analysis for HERC1-PCLAF

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000443617ENST00000558008HERC1chr15

64045157

-KIAA0101chr15

64658274

-
5CDS-3UTRENST00000443617ENST00000558008HERC1chr15

63970044

-KIAA0101chr15

64658274

-
5CDS-intronENST00000443617ENST00000558250HERC1chr15

64045157

-KIAA0101chr15

64658274

-
5CDS-intronENST00000443617ENST00000558250HERC1chr15

63970044

-KIAA0101chr15

64658274

-
Frame-shiftENST00000443617ENST00000300035HERC1chr15

63970044

-KIAA0101chr15

64658274

-
Frame-shiftENST00000443617ENST00000380258HERC1chr15

64045157

-KIAA0101chr15

64658274

-
Frame-shiftENST00000443617ENST00000559519HERC1chr15

63970044

-KIAA0101chr15

64658274

-
In-frameENST00000443617ENST00000300035HERC1chr15

64045157

-KIAA0101chr15

64658274

-
In-frameENST00000443617ENST00000380258HERC1chr15

63970044

-KIAA0101chr15

64658274

-
In-frameENST00000443617ENST00000559519HERC1chr15

64045157

-KIAA0101chr15

64658274

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000443617HERC1chr1563970044-ENST00000380258KIAA0101chr1564658274-786971588872032371
ENST00000443617HERC1chr1564045157-ENST00000300035KIAA0101chr1564658274-30721990882010640
ENST00000443617HERC1chr1564045157-ENST00000559519KIAA0101chr1564658274-24601990882010640

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000443617ENST00000380258HERC1chr1563970044-KIAA0101chr1564658274-0.0010170520.99898297
ENST00000443617ENST00000300035HERC1chr1564045157-KIAA0101chr1564658274-0.0050234380.99497664
ENST00000443617ENST00000559519HERC1chr1564045157-KIAA0101chr1564658274-0.0074706540.99252933

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Fusion Genomic Features for HERC1-PCLAF


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for HERC1-PCLAF


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:63970044/:64658274)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HERC1

Q15751

.
FUNCTION: Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHERC1chr15:63970044chr15:64658274ENST00000443617-37781349_137823564862.0Compositional biasNote=Glu-rich
HgeneHERC1chr15:63970044chr15:64658274ENST00000443617-37782002_219323564862.0DomainB30.2/SPRY
HgeneHERC1chr15:63970044chr15:64658274ENST00000443617-3778371_42023564862.0RepeatNote=RCC1 1
HgeneHERC1chr15:63970044chr15:64658274ENST00000443617-3778421_47523564862.0RepeatNote=RCC1 2
HgeneHERC1chr15:63970044chr15:64658274ENST00000443617-3778476_52823564862.0RepeatNote=RCC1 3
HgeneHERC1chr15:63970044chr15:64658274ENST00000443617-3778529_57823564862.0RepeatNote=RCC1 4
HgeneHERC1chr15:63970044chr15:64658274ENST00000443617-3778580_63123564862.0RepeatNote=RCC1 5
HgeneHERC1chr15:63970044chr15:64658274ENST00000443617-3778633_68223564862.0RepeatNote=RCC1 6
HgeneHERC1chr15:63970044chr15:64658274ENST00000443617-3778683_73523564862.0RepeatNote=RCC1 7
HgeneHERC1chr15:64045157chr15:64658274ENST00000443617-878371_4206344862.0RepeatNote=RCC1 1
HgeneHERC1chr15:64045157chr15:64658274ENST00000443617-878421_4756344862.0RepeatNote=RCC1 2
HgeneHERC1chr15:64045157chr15:64658274ENST00000443617-878476_5286344862.0RepeatNote=RCC1 3
HgeneHERC1chr15:64045157chr15:64658274ENST00000443617-878529_5786344862.0RepeatNote=RCC1 4
HgeneHERC1chr15:64045157chr15:64658274ENST00000443617-878580_6316344862.0RepeatNote=RCC1 5
TgeneKIAA0101chr15:63970044chr15:64658274ENST000003802581362_724266.0MotifNote=PIP-box
TgeneKIAA0101chr15:63970044chr15:64658274ENST000003802581378_804266.0MotifNote=KEN box
TgeneKIAA0101chr15:63970044chr15:64658274ENST000003802581385_974266.0MotifNote=Initiation motif
TgeneKIAA0101chr15:64045157chr15:64658274ENST000003802581362_724266.0MotifNote=PIP-box
TgeneKIAA0101chr15:64045157chr15:64658274ENST000003802581378_804266.0MotifNote=KEN box
TgeneKIAA0101chr15:64045157chr15:64658274ENST000003802581385_974266.0MotifNote=Initiation motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHERC1chr15:64045157chr15:64658274ENST00000443617-8781349_13786344862.0Compositional biasNote=Glu-rich
HgeneHERC1chr15:63970044chr15:64658274ENST00000443617-37784501_484823564862.0DomainHECT
HgeneHERC1chr15:64045157chr15:64658274ENST00000443617-8782002_21936344862.0DomainB30.2/SPRY
HgeneHERC1chr15:64045157chr15:64658274ENST00000443617-8784501_48486344862.0DomainHECT
HgeneHERC1chr15:63970044chr15:64658274ENST00000443617-37783426_346523564862.0RepeatNote=WD 1
HgeneHERC1chr15:63970044chr15:64658274ENST00000443617-37783484_352223564862.0RepeatNote=WD 2
HgeneHERC1chr15:63970044chr15:64658274ENST00000443617-37783524_357223564862.0RepeatNote=WD 3
HgeneHERC1chr15:63970044chr15:64658274ENST00000443617-37783580_361923564862.0RepeatNote=WD 4
HgeneHERC1chr15:63970044chr15:64658274ENST00000443617-37783624_366323564862.0RepeatNote=WD 5
HgeneHERC1chr15:63970044chr15:64658274ENST00000443617-37783667_371323564862.0RepeatNote=WD 6
HgeneHERC1chr15:63970044chr15:64658274ENST00000443617-37783745_378423564862.0RepeatNote=WD 7
HgeneHERC1chr15:63970044chr15:64658274ENST00000443617-37783996_404423564862.0RepeatNote=RCC1 8
HgeneHERC1chr15:63970044chr15:64658274ENST00000443617-37784046_409923564862.0RepeatNote=RCC1 9
HgeneHERC1chr15:63970044chr15:64658274ENST00000443617-37784101_415123564862.0RepeatNote=RCC1 10
HgeneHERC1chr15:63970044chr15:64658274ENST00000443617-37784153_420323564862.0RepeatNote=RCC1 11
HgeneHERC1chr15:63970044chr15:64658274ENST00000443617-37784205_425623564862.0RepeatNote=RCC1 12
HgeneHERC1chr15:63970044chr15:64658274ENST00000443617-37784258_430823564862.0RepeatNote=RCC1 13
HgeneHERC1chr15:63970044chr15:64658274ENST00000443617-37784310_436023564862.0RepeatNote=RCC1 14
HgeneHERC1chr15:64045157chr15:64658274ENST00000443617-8783426_34656344862.0RepeatNote=WD 1
HgeneHERC1chr15:64045157chr15:64658274ENST00000443617-8783484_35226344862.0RepeatNote=WD 2
HgeneHERC1chr15:64045157chr15:64658274ENST00000443617-8783524_35726344862.0RepeatNote=WD 3
HgeneHERC1chr15:64045157chr15:64658274ENST00000443617-8783580_36196344862.0RepeatNote=WD 4
HgeneHERC1chr15:64045157chr15:64658274ENST00000443617-8783624_36636344862.0RepeatNote=WD 5
HgeneHERC1chr15:64045157chr15:64658274ENST00000443617-8783667_37136344862.0RepeatNote=WD 6
HgeneHERC1chr15:64045157chr15:64658274ENST00000443617-8783745_37846344862.0RepeatNote=WD 7
HgeneHERC1chr15:64045157chr15:64658274ENST00000443617-8783996_40446344862.0RepeatNote=RCC1 8
HgeneHERC1chr15:64045157chr15:64658274ENST00000443617-8784046_40996344862.0RepeatNote=RCC1 9
HgeneHERC1chr15:64045157chr15:64658274ENST00000443617-8784101_41516344862.0RepeatNote=RCC1 10
HgeneHERC1chr15:64045157chr15:64658274ENST00000443617-8784153_42036344862.0RepeatNote=RCC1 11
HgeneHERC1chr15:64045157chr15:64658274ENST00000443617-8784205_42566344862.0RepeatNote=RCC1 12
HgeneHERC1chr15:64045157chr15:64658274ENST00000443617-8784258_43086344862.0RepeatNote=RCC1 13
HgeneHERC1chr15:64045157chr15:64658274ENST00000443617-8784310_43606344862.0RepeatNote=RCC1 14
HgeneHERC1chr15:64045157chr15:64658274ENST00000443617-878633_6826344862.0RepeatNote=RCC1 6
HgeneHERC1chr15:64045157chr15:64658274ENST00000443617-878683_7356344862.0RepeatNote=RCC1 7
TgeneKIAA0101chr15:63970044chr15:64658274ENST000003000352423_3496112.0MotifNote=D-box
TgeneKIAA0101chr15:63970044chr15:64658274ENST000003000352462_7296112.0MotifNote=PIP-box
TgeneKIAA0101chr15:63970044chr15:64658274ENST000003000352478_8096112.0MotifNote=KEN box
TgeneKIAA0101chr15:63970044chr15:64658274ENST000003000352485_9796112.0MotifNote=Initiation motif
TgeneKIAA0101chr15:63970044chr15:64658274ENST000003802581323_344266.0MotifNote=D-box
TgeneKIAA0101chr15:64045157chr15:64658274ENST000003000352423_3496112.0MotifNote=D-box
TgeneKIAA0101chr15:64045157chr15:64658274ENST000003000352462_7296112.0MotifNote=PIP-box
TgeneKIAA0101chr15:64045157chr15:64658274ENST000003000352478_8096112.0MotifNote=KEN box
TgeneKIAA0101chr15:64045157chr15:64658274ENST000003000352485_9796112.0MotifNote=Initiation motif
TgeneKIAA0101chr15:64045157chr15:64658274ENST000003802581323_344266.0MotifNote=D-box


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Fusion Gene Sequence for HERC1-PCLAF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>36134_36134_1_HERC1-KIAA0101_HERC1_chr15_63970044_ENST00000443617_KIAA0101_chr15_64658274_ENST00000380258_length(transcript)=7869nt_BP=7158nt
CCTCTGCGGAGCCGGGCTCGGGTCGCCGGAGCCGCGCCCCACCCCGCCAGCTCCAGAGCCACGACTAATGGCTGAAGGATAAATCAACAT
GGCAACTATGATTCCACCAGTGAAGCTGAAATGGCTTGAACACTTGAACAGCTCCTGGATTACAGAGGACAGTGAATCTATTGCTACAAG
AGAGGGAGTTGCTGTTCTGTATTCTAAACTGGTTAGCAATAAGGAAGTAGTACCTTTGCCCCAACAAGTTTTATGCCTCAAAGGACCACA
GTTGCCAGACTTTGAACGTGAGTCTCTTTCAAGTGATGAGCAGGACCACTATTTGGATGCCCTTCTTAGCAGCCAGCTAGCATTGGCAAA
GATGGTATGTTCAGATTCCCCATTTGCCGGGGCACTTAGAAAACGACTGCTTGTACTCCAGCGTGTCTTTTATGCACTTTCTAATAAATA
CCATGACAAAGGCAAGGTGAAGCAGCAGCAGCATTCTCCGGAGAGCAGTTCTGGTTCAGCAGATGTCCATTCTGTTAGTGAACGCCCCCG
GTCAAGCACTGATGCACTTATAGAAATGGGTGTTCGAACTGGTCTAAGTTTATTATTTGCGCTTCTAAGACAAAGTTGGATGATGCCTGT
GTCAGGACCTGGTCTCAGTCTTTGCAACGATGTCATTCATACTGCAATTGAAGTTGTGAGCTCTTTGCCACCATTATCATTAGCAAATGA
AAGCAAGATTCCTCCTATGGGCTTGGACTGCTTATCGCAAGTAACAACATTTCTTAAAGGAGTCACTATTCCTAATTCTGGGGCAGACAC
TTTAGGTCGTAGATTAGCTTCTGAGTTGCTGCTTGGTTTGGCAGCTCAACGAGGCTCATTGCGATATCTTCTTGAATGGATAGAAATGGC
TTTGGGGGCTTCGGCAGTTGTACACACCATGGAGAAAGGCAAACTACTCTCAAGCCAGGAAGGAATGATCAGCTTTGACTGCTTTATGAC
CATATTAATGCAGATGAGGCGTTCTTTGGGTTCATCTGCTGATCGGAGTCAGTGGAGAGAACCAACCAGAACATCGGATGGCTTGTGCTC
CCTTTACGAGGCAGCATTATGTCTCTTTGAAGAGGTTTGCAGAATGGCTTCTGATTATTCGAGAACATGTGCTAGCCCAGATAGCATTCA
GACTGGTGATGCTCCCATTGTCTCCGAAACCTGTGAGGTTTATGTTTGGGGGAGCAATAGCAGCCATCAGTTGGTAGAAGGTACACAGGA
GAAAATACTGCAACCCAAACTGGCTCCTAGTTTCTCTGATGCACAGACCATTGAAGCTGGACAGTACTGCACTTTTGTCATTTCTACGGA
TGGCTCTGTTAGAGCTTGCGGGAAAGGCAGCTATGGGAGACTGGGCCTTGGAGACTCCAATAATCAGTCAACTTTAAAAAAGTTAACATT
CGAGCCTCACAGATCCATTAAAAAGGTTTCATCTTCTAAAGGATCTGATGGTCACACTTTAGCCTTTACGACAGAAGGAGAAGTCTTCAG
TTGGGGAGATGGTGATTATGGGAAACTGGGGCATGGAAATAGTTCAACACAGAAATATCCCAAGCTTATTCAGGGACCTCTACAAGGAAA
GGTAGTTGTTTGTGTGTCAGCTGGATACAGACATAGTGCTGCTGTCACAGAGGATGGGGAATTATACACATGGGGTGAAGGAGACTTTGG
AAGATTAGGTCATGGTGACAGCAATAGTCGTAACATTCCAACATTAGTAAAAGACATCAGCAATGTAGGAGAGGTTTCTTGTGGCAGTTC
ACATACTATTGCTCTGTCTAAAGATGGGAGAACTGTATGGTCTTTTGGAGGAGGAGACAATGGTAAACTTGGTCATGGTGATACCAACAG
AGTGTATAAACCTAAAGTTATTGAAGCTTTACAAGGAATGTTCATTCGCAAAGTTTGTGCTGGGAGCCAGTCTTCACTTGCTTTGACATC
AACAGGGCAGGTCTATGCTTGGGGCTGTGGAGCTTGTCTAGGTTGTGGTTCTTCAGAAGCTACTGCTTTGAGACCCAAGCTTATTGAAGA
ACTGGCTGCCACAAGAATAGTTGATGTTTCTATTGGAGACAGTCATTGTTTGGCTCTTTCTCATGATAATGAAGTTTATGCCTGGGGCAA
TAACTCAATGGGGCAATGTGGTCAGGGAAATTCCACAGGTCCTATTACTAAACCAAAGAAAGTGAGTGGCTTAGATGGCATAGCTATTCA
GCAGATTTCGGCTGGAACATCACATAGTCTGGCATGGACTGCTCTTCCTAGGGACAGACAAGTTGTTGCATGGCACCGACCTTATTGTGT
AGATCTTGAAGAGAGTACCTTCTCACACCTGCGTTCTTTTCTTGAGAGATACTGTGATAAAATAAACAGTGAGATTCCCCCACTCCCTTT
CCCTTCATCAAGAGAACACCACAGTTTTCTCAAGCTGTGCCTGAAGCTACTTTCAAATCACCTTGCTCTTGCACTTGCGGGAGGGGTAGC
TACCAGCATTCTCGGGAGGCAGGCAGGTCCACTTCGAAATTTGCTCTTCAGACTGATGGACTCAACTGTCCCAGATGAAATCCAAGAGGT
GGTAATTGAAACTTTATCAGTGGGAGCAACCATGCTGTTACCTCCATTACGAGAACGGATGGAATTACTTCATTCTCTTTTACCTCAAGG
ACCTGATAGATGGGAAAGCTTATCTAAAGGACAGAGAATGCAACTGGATATCATCCTGACAAGTTTGCAAGATCATACCCACGTAGCCTC
CCTACTTGGCTATAGTTCACCCTCTGATGCTGCTGACCTATCTTCTGTGTGTACTGGCTACGGAAATCTGTCAGATCAACCTTACGGCAC
TCAGAGCTGCCATCCAGATACCCACCTGGCTGAAATTTTGATGAAGACCCTCTTAAGAAATTTAGGATTTTATACAGATCAAGCATTTGG
AGAGCTAGAAAAGAATAGTGATAAATTTCTACTTGGAACATCATCATCAGAAAACAGTCAGCCTGCTCATCTTCATGAACTGCTATGTTC
ACTACAGAAACAGCTGCTGGCATTTTGCCATATCAATAACATTAGTGAGAACTCAAGCAGTGTGGCATTGCTTCATAAACATCTTCAGCT
TTTGTTGCCTCATGCCACAGATATTTATTCACGTTCTGCAAATTTGCTCAAAGAAAGTCCTTGGAATGGCAGTGTTGGAGAAAAATTAAG
AGATGTGATATACGTCTCAGCTGCTGGCAGTATGCTCTGCCAGATTGTTAACTCCCTGCTGTTACTCCCTGTGTCAGTGGCTCGGCCTTT
ATTGAGTTACCTCCTCGACTTGTTGCCACCTCTTGATTGCCTTAATAGACTCCTGCCAGCTGCTGATCTTTTAGAAGACCAGGAGTTACA
GTGGCCTCTTCATGGAGGGCCAGAACTAATTGATCCTGCTGGTCTGCCATTACCTCAGCCAGCTCAGTCCTGGGTATGGCTTGTGGATCT
AGAAAGAACAATTGCTCTCCTTATTGGGCGGTGTCTTGGTGGCATGCTTCAGGGCTCCCCTGTGTCTCCAGAGGAACAGGACACTGCATA
TTGGATGAAAACGCCACTGTTCAGTGACGGTGTAGAAATGGACACTCCTCAATTGGATAAATGTATGAGTTGCCTGTTAGAAGTAGCACT
TTCTGGAAATGAAGAACAGAAGCCTTTTGATTATAAATTGCGGCCTGAAATTGCTGTCTATGTAGACTTGGCATTGGGTTGTTCTAAAGA
GCCTGCCCGAAGCCTTTGGATCAGCATGCAGGACTATGCTGTTAGTAAAGATTGGGACAGTGCAACTTTAAGTAATGAGTCACTCTTGGA
CACTGTGTCTAGATTTGTTCTTGCAGCTCTTCTGAAACACACAAATTTACTTAGTCAAGCATGTGGAGAAAGCCGATATCAACCTGGTAA
ACACTTATCAGAAGTGTACCGTTGTGTATACAAAGTTCGAAGTCGTTTACTTGCTTGCAAGAACCTTGAACTTATTCAAACAAGGTCATC
ATCACGGGACAGATGGATATCAGAAAACCAGGACTCTGCAGATGTTGATCCTCAGGAGCATTCATTTACTCGAACTATTGATGAAGAAGC
TGAAATGGAAGAACAGGCTGAGAGAGACCGGGAAGAGGGGCATCCGGAGCCAGAGGATGAAGAGGAGGAACGGGAACATGAAGTGATGAC
AGCTGGCAAAATCTTTCAGTGTTTCCTCTCAGCCCGTGAAGTAGCTCGTAGCCGAGACCGAGATAGAATGAACAGTGGGGCAGGGTCTGG
GGCTCGAGCTGATGATCCACCTCCTCAGTCTCAGCAAGAGCGAAGGGTCAGCACAGACCTTCCTGAGGGTCAGGATGTGTACACTGCTGC
ATGCAACTCCGTGATCCATCGGTGTGCCCTGTTAATATTAGGAGTAAGTCCTGTGATAGATGAGCTTCAGAAGCGAAGAGAAGAAGGACA
GTTGCAGCAACCTTCAACAAGTGCCTCTGAAGGGGGTGGACTTATGACCAGGAGTGAAAGTCTTACTGCAGAGAGCCGGCTAGTCCACAC
AAGCCCAAATTATAGACTGATCAAATCGAGGAGTGAATCTGATTTGTCTCAGCCTGAATCAGATGAAGAGGGTTACGCACTGAGTGGCAG
ACGAAATGTTGATTTGGATTTGGCAGCATCTCACAGAAAGAGAGGTCCTATGCACAGTCAATTGGAATCCCTGAGTGACTCTTGGGCTCG
CCTGAAACATAGCAGAGACTGGTTATGCAACTCCTCCTATTCCTTTGAGTCAGATTTTGATCTTACCAAGTCTTTGGGAGTTCACACTTT
GATTGAAAATGTTGTAAGCTTTGTGAGTGGAGATGTGGGGAATGCCCCAGGTTTTAAAGAGCCAGAGGAAAGTATGTCTACAAGTCCCCA
GGCCTCCATCATTGCAATGGAACAGCAGCAGTTAAGGGCAGAACTTCGTTTAGAGGCACTTCATCAGATCCTCGTTCTATTGTCTGGGAT
GGAAGAAAAAGGTAGCATCTCACTGGCAGGAAGCAGATTGAGTTCAGGCTTCCAGTCCTCCACACTACTCACGTCTGTGAGGCTGCAGTT
CCTAGCAGGGTGTTTTGGTTTAGGCACTGTTGGACACACAGGAGGCAAGGGAGAGAGTGGCCGATTGCATCACTATCAGGATGGGATCAG
AGCAGCTAAGAGAAATATTCAGATTGAAATCCAGGTAGCTGTGCATAAAATTTATCAACAGTTGTCTGCTACCCTGGAAAGAGCCCTGCA
AGCAAACAAGCATCACATTGAAGCCCAGCAACGTCTGCTTCTGGTTACAGTTTTTGCCCTAAGTGTTCATTATCAACCAGTAGATGTTTC
TTTGGCAATTTCCACTGGTCTGCTAAACGTATTGTCACAGTTGTGTGGTACAGACACCATGCTAGGACAGCCCCTGCAGTTGTTGCCAAA
GACGGGTGTTTCCCAGCTTAGCACAGCTTTGAAAGTGGCCAGTACAAGGTTGCTCCAGATTCTAGCCATCACTACTGGGACCTATGCTGA
TAAACTGAGTCCCAAAGTAGTTCAATCCTTGTTGGATCTACTCTGTAGTCAGTTGAAGAATTTATTGTCCCAAACTGGTGTACTACATAT
GGCCTCTTTCGGAGAAGGGGAGCAAGAAGACGGTGAAGAAGAAGAAAAAAAAGTTGACTCCAGTGGAGAAACTGAGAAGAAAGATTTCAG
AGCTGCTCTTAGGAAACAACATGCAGCCGAACTCCATCTAGGGGATTTTTTAGTTTTTCTTCGCAGAGTTGTATCTTCAAAAGCAATTCA
ATCAAAAATGGCTTCCCCAAAGTGGACCGAAGTGCTTCTAAATATAGCATCTCAGAAATGTTCTTCAGGTATCCCTCTGGTTGGTAACTT
AAGAACAAGGCTCCTTGCACTTCATGTCCTTGAAGCTGTGCTGCCAGCTTGTGAATCTGGTGTAGAAGATGATCAAATGGCCCAGATTGT
TGAGCGCTTATTTTCCCTTCTCTCTGATTGTATGTGGGAGACACCCATTGCTCAGGCCAAACATGCTATTCAGATAAAGGAAAAAGAACA
AGAAATAAAACTACAGAAGCAGGGCGAGTTGGAAGAAGAAGATGAGAATCTTCCTATCCAAGAAGTATCCTTTGACCCGGAGAAAGCTCA
GTGTTGCCTAGTGGAGAATGGACAGATTTTAACTCACGGCAGTGGAGGGAAAGGATATGGATTGGCATCTACAGGAGTAACTTCTGGGTG
CTATCAGTGGAAGTTTTATATTGTGAAGGAAAACAGAGGTAATGAAGGCACGTGTGTTGGAGTTTCTCGCTGGCCAGTACATGACTTTAA
TCACCGCACTACCTCGGATATGTGGCTCTATAGGGCCTACAGTGGTAACCTCTATCACAATGGAGAACAGACTCTCACATTGTCCAGCTT
TACTCAAGGAGATTTCATTACCTGTGTGTTAGACATGGAAGCCAGGACCATTTCTTTTGGGAAAAATGGAGAGGAACCCAAATTAGCTTT
TGAAGATGTGGATGCAGCAGAGTTGTACCCATGTGTGATGTTCTATAGTAGCAATCCAGGGGAAAAGGTGAAAATTTGTGATATGCAGAT
GCGTGGCACACCCCGAGACTTACTTCCAGGAGACCCTATTTGTAGTCCAGTAGCAGCAGTGCTGGCTGAGGCCACTATTCAGCTCATCCG
TATCCTTCACCGAACAGACCGTTGGACTTACTGCATTAACAAAAAAATGATGGAAAGGCTTCACAAAATTAAGATATGTATTAAAGAGTC
AGGTCAGAAGCTAAAGAAAAGCCGCTCGGTTCAGAGCCGAGAGGAAAATGAAATGAGAGAGGAGAAGGAGAGCAAAGAGGAAGAGAAAGG
TAAACATACTAGGCATGGCCTCGCTGACCTCTCAGAGCTGCAGCTGAGGACTCTTTGCATAGAGGTGTGGCCCGTGCTGGCTGTGATAGG
AGGAGTTGATGCTGGTCTTAGAGTTGGAGGTCGGTGTGTTCACAAGCAAACTGGGCGCCATGCCACGCTGCTGGGAGTGGTCAAAGAGGG
CAGCACGTCTGCCAAGGTCCAATGGGATGAAGCAGAAATTACTATCAGAGCATGTCCTTTGCAACCTGATCACACAAATGATGAAAAAGA
ATAGAACTTTCTCATTCATCTTTGAATAACGTCTCCTTGTTTACCCTGGTATTCTAGAATGTAAATTTACATAAATGTGTTTGTTCCAAT
TAGCTTTGTTGAACAGGCATTTAATTAAAAAATTTAGGTTTAAATTTAGATGTTCAAAAGTAGTTGTGAAATTTGAGAATTTGTAAGACT
AATTATGGTAACTTAGCTTAGTATTCAATATAATGCATTGTTTGGTTTCTTTTACCAAATTAAGTGTCTAGTTCTTGCTAAAATCAAGTC
ATTGCATTGTGTTCTAATTACAAGTATGTTGTATTTGAGATTTGCTTAGATTGTTGTACTGCTGCCATTTTTATTGGTGTTTGATTATTG
GAATGGTGCCATATTGTCACTCCTTCTACTTGCTTTAAAAAGCAGAGTTAGATTTTTGCACATTAAAAAATTCAGTATTAATTAAACATT
ACTTATTCTACCCTCTTTTTTGGCAAGGAGGACAAATACGCAATGTTGGAAAACCTTGGATGGATATCTTCTCTTTAAAAAAATGTAAAG
ATAATTTGGTCTTGAGGGTTTAAACGGTTGATAATGCCTCTACAACAACAAGAAAAAAGATAAAATACTAGGATAGAATCATGGTGGGCA

>36134_36134_1_HERC1-KIAA0101_HERC1_chr15_63970044_ENST00000443617_KIAA0101_chr15_64658274_ENST00000380258_length(amino acids)=2371AA_BP=2356
MATMIPPVKLKWLEHLNSSWITEDSESIATREGVAVLYSKLVSNKEVVPLPQQVLCLKGPQLPDFERESLSSDEQDHYLDALLSSQLALA
KMVCSDSPFAGALRKRLLVLQRVFYALSNKYHDKGKVKQQQHSPESSSGSADVHSVSERPRSSTDALIEMGVRTGLSLLFALLRQSWMMP
VSGPGLSLCNDVIHTAIEVVSSLPPLSLANESKIPPMGLDCLSQVTTFLKGVTIPNSGADTLGRRLASELLLGLAAQRGSLRYLLEWIEM
ALGASAVVHTMEKGKLLSSQEGMISFDCFMTILMQMRRSLGSSADRSQWREPTRTSDGLCSLYEAALCLFEEVCRMASDYSRTCASPDSI
QTGDAPIVSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLT
FEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDF
GRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALT
STGQVYAWGCGACLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAI
QQISAGTSHSLAWTALPRDRQVVAWHRPYCVDLEESTFSHLRSFLERYCDKINSEIPPLPFPSSREHHSFLKLCLKLLSNHLALALAGGV
ATSILGRQAGPLRNLLFRLMDSTVPDEIQEVVIETLSVGATMLLPPLRERMELLHSLLPQGPDRWESLSKGQRMQLDIILTSLQDHTHVA
SLLGYSSPSDAADLSSVCTGYGNLSDQPYGTQSCHPDTHLAEILMKTLLRNLGFYTDQAFGELEKNSDKFLLGTSSSENSQPAHLHELLC
SLQKQLLAFCHINNISENSSSVALLHKHLQLLLPHATDIYSRSANLLKESPWNGSVGEKLRDVIYVSAAGSMLCQIVNSLLLLPVSVARP
LLSYLLDLLPPLDCLNRLLPAADLLEDQELQWPLHGGPELIDPAGLPLPQPAQSWVWLVDLERTIALLIGRCLGGMLQGSPVSPEEQDTA
YWMKTPLFSDGVEMDTPQLDKCMSCLLEVALSGNEEQKPFDYKLRPEIAVYVDLALGCSKEPARSLWISMQDYAVSKDWDSATLSNESLL
DTVSRFVLAALLKHTNLLSQACGESRYQPGKHLSEVYRCVYKVRSRLLACKNLELIQTRSSSRDRWISENQDSADVDPQEHSFTRTIDEE
AEMEEQAERDREEGHPEPEDEEEEREHEVMTAGKIFQCFLSAREVARSRDRDRMNSGAGSGARADDPPPQSQQERRVSTDLPEGQDVYTA
ACNSVIHRCALLILGVSPVIDELQKRREEGQLQQPSTSASEGGGLMTRSESLTAESRLVHTSPNYRLIKSRSESDLSQPESDEEGYALSG
RRNVDLDLAASHRKRGPMHSQLESLSDSWARLKHSRDWLCNSSYSFESDFDLTKSLGVHTLIENVVSFVSGDVGNAPGFKEPEESMSTSP
QASIIAMEQQQLRAELRLEALHQILVLLSGMEEKGSISLAGSRLSSGFQSSTLLTSVRLQFLAGCFGLGTVGHTGGKGESGRLHHYQDGI
RAAKRNIQIEIQVAVHKIYQQLSATLERALQANKHHIEAQQRLLLVTVFALSVHYQPVDVSLAISTGLLNVLSQLCGTDTMLGQPLQLLP
KTGVSQLSTALKVASTRLLQILAITTGTYADKLSPKVVQSLLDLLCSQLKNLLSQTGVLHMASFGEGEQEDGEEEEKKVDSSGETEKKDF
RAALRKQHAAELHLGDFLVFLRRVVSSKAIQSKMASPKWTEVLLNIASQKCSSGIPLVGNLRTRLLALHVLEAVLPACESGVEDDQMAQI
VERLFSLLSDCMWETPIAQAKHAIQIKEKEQEIKLQKQGELEEEDENLPIQEVSFDPEKAQCCLVENGQILTHGSGGKGYGLASTGVTSG
CYQWKFYIVKENRGNEGTCVGVSRWPVHDFNHRTTSDMWLYRAYSGNLYHNGEQTLTLSSFTQGDFITCVLDMEARTISFGKNGEEPKLA
FEDVDAAELYPCVMFYSSNPGEKVKICDMQMRGTPRDLLPGDPICSPVAAVLAEATIQLIRILHRTDRWTYCINKKMMERLHKIKICIKE
SGQKLKKSRSVQSREENEMREEKESKEEEKGKHTRHGLADLSELQLRTLCIEVWPVLAVIGGVDAGLRVGGRCVHKQTGRHATLLGVVKE

--------------------------------------------------------------
>36134_36134_2_HERC1-KIAA0101_HERC1_chr15_64045157_ENST00000443617_KIAA0101_chr15_64658274_ENST00000300035_length(transcript)=3072nt_BP=1990nt
CCTCTGCGGAGCCGGGCTCGGGTCGCCGGAGCCGCGCCCCACCCCGCCAGCTCCAGAGCCACGACTAATGGCTGAAGGATAAATCAACAT
GGCAACTATGATTCCACCAGTGAAGCTGAAATGGCTTGAACACTTGAACAGCTCCTGGATTACAGAGGACAGTGAATCTATTGCTACAAG
AGAGGGAGTTGCTGTTCTGTATTCTAAACTGGTTAGCAATAAGGAAGTAGTACCTTTGCCCCAACAAGTTTTATGCCTCAAAGGACCACA
GTTGCCAGACTTTGAACGTGAGTCTCTTTCAAGTGATGAGCAGGACCACTATTTGGATGCCCTTCTTAGCAGCCAGCTAGCATTGGCAAA
GATGGTATGTTCAGATTCCCCATTTGCCGGGGCACTTAGAAAACGACTGCTTGTACTCCAGCGTGTCTTTTATGCACTTTCTAATAAATA
CCATGACAAAGGCAAGGTGAAGCAGCAGCAGCATTCTCCGGAGAGCAGTTCTGGTTCAGCAGATGTCCATTCTGTTAGTGAACGCCCCCG
GTCAAGCACTGATGCACTTATAGAAATGGGTGTTCGAACTGGTCTAAGTTTATTATTTGCGCTTCTAAGACAAAGTTGGATGATGCCTGT
GTCAGGACCTGGTCTCAGTCTTTGCAACGATGTCATTCATACTGCAATTGAAGTTGTGAGCTCTTTGCCACCATTATCATTAGCAAATGA
AAGCAAGATTCCTCCTATGGGCTTGGACTGCTTATCGCAAGTAACAACATTTCTTAAAGGAGTCACTATTCCTAATTCTGGGGCAGACAC
TTTAGGTCGTAGATTAGCTTCTGAGTTGCTGCTTGGTTTGGCAGCTCAACGAGGCTCATTGCGATATCTTCTTGAATGGATAGAAATGGC
TTTGGGGGCTTCGGCAGTTGTACACACCATGGAGAAAGGCAAACTACTCTCAAGCCAGGAAGGAATGATCAGCTTTGACTGCTTTATGAC
CATATTAATGCAGATGAGGCGTTCTTTGGGTTCATCTGCTGATCGGAGTCAGTGGAGAGAACCAACCAGAACATCGGATGGCTTGTGCTC
CCTTTACGAGGCAGCATTATGTCTCTTTGAAGAGGTTTGCAGAATGGCTTCTGATTATTCGAGAACATGTGCTAGCCCAGATAGCATTCA
GACTGGTGATGCTCCCATTGTCTCCGAAACCTGTGAGGTTTATGTTTGGGGGAGCAATAGCAGCCATCAGTTGGTAGAAGGTACACAGGA
GAAAATACTGCAACCCAAACTGGCTCCTAGTTTCTCTGATGCACAGACCATTGAAGCTGGACAGTACTGCACTTTTGTCATTTCTACGGA
TGGCTCTGTTAGAGCTTGCGGGAAAGGCAGCTATGGGAGACTGGGCCTTGGAGACTCCAATAATCAGTCAACTTTAAAAAAGTTAACATT
CGAGCCTCACAGATCCATTAAAAAGGTTTCATCTTCTAAAGGATCTGATGGTCACACTTTAGCCTTTACGACAGAAGGAGAAGTCTTCAG
TTGGGGAGATGGTGATTATGGGAAACTGGGGCATGGAAATAGTTCAACACAGAAATATCCCAAGCTTATTCAGGGACCTCTACAAGGAAA
GGTAGTTGTTTGTGTGTCAGCTGGATACAGACATAGTGCTGCTGTCACAGAGGATGGGGAATTATACACATGGGGTGAAGGAGACTTTGG
AAGATTAGGTCATGGTGACAGCAATAGTCGTAACATTCCAACATTAGTAAAAGACATCAGCAATGTAGGAGAGGTTTCTTGTGGCAGTTC
ACATACTATTGCTCTGTCTAAAGATGGGAGAACTGTATGGTCTTTTGGAGGAGGAGACAATGGTAAACTTGGTCATGGTGATACCAACAG
AGTGTATAAACCTAAAGTTATTGAAGCTTTACAAGGAATGTTCATTCGCAAAGTTTGTGCTGGGAGCCAGTCTTCACTTGCTTTGACATC
AACAGGGCAGAGCATGTCCTTTGCAACCTGATCACACAAATGATGAAAAAGAATAGAACTTTCTCATTCATCTTTGAATAACGTCTCCTT
GTTTACCCTGGTATTCTAGAATGTAAATTTACATAAATGTGTTTGTTCCAATTAGCTTTGTTGAACAGGCATTTAATTAAAAAATTTAGG
TTTAAATTTAGATGTTCAAAAGTAGTTGTGAAATTTGAGAATTTGTAAGACTAATTATGGTAACTTAGCTTAGTATTCAATATAATGCAT
TGTTTGGTTTCTTTTACCAAATTAAGTGTCTAGTTCTTGCTAAAATCAAGTCATTGCATTGTGTTCTAATTACAAGTATGTTGTATTTGA
GATTTGCTTAGATTGTTGTACTGCTGCCATTTTTATTGGTGTTTGATTATTGGAATGGTGCCATATTGTCACTCCTTCTACTTGCTTTAA
AAAGCAGAGTTAGATTTTTGCACATTAAAAAATTCAGTATTAATTAAACATTACTTATTCTACCCTCTTTTTTGGCAAGGAGGACAAATA
CGCAATGTTGGAAAACCTTGGATGGATATCTTCTCTTTAAAAAAATGTAAAGATAATTTGGTCTTGAGGGTTTAAACGGTTGATAATGCC
TCTACAACAACAAGAAAAAAGATAAAATACTAGGATAGAATCATGGTGGGCACAGTGGCTTCTCAGGAGGCTGAGGAGGGAGGTTTGCTT
GAGTCCAGGAGTTGGAGACCAGCCCAGGCAACATAGCGTAAACCCTATCTCTAAAACAATTTTTAGCCGGGTGCGGTGGCTCACGCCTGT
AATCCCAGCACTCTGGGAGGCCGAGGCGGGTGGATCATGAGGTCAGGAGATCGAGACCATCCTGCCTAACAAGGTGAAACCCCGTCTCTA
CTAAAAATACAAAAAATTAGCCGGGCGCGGTGGCGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCC
GGGAAGTGGAGCTTGCAGTGAGCCGAGATTGCGCCACTGCAGTCGGCAGTCCGGCTTGGGCGACAGAGCGAGACTCCGTCTCAAAAAAAA

>36134_36134_2_HERC1-KIAA0101_HERC1_chr15_64045157_ENST00000443617_KIAA0101_chr15_64658274_ENST00000300035_length(amino acids)=640AA_BP=
MATMIPPVKLKWLEHLNSSWITEDSESIATREGVAVLYSKLVSNKEVVPLPQQVLCLKGPQLPDFERESLSSDEQDHYLDALLSSQLALA
KMVCSDSPFAGALRKRLLVLQRVFYALSNKYHDKGKVKQQQHSPESSSGSADVHSVSERPRSSTDALIEMGVRTGLSLLFALLRQSWMMP
VSGPGLSLCNDVIHTAIEVVSSLPPLSLANESKIPPMGLDCLSQVTTFLKGVTIPNSGADTLGRRLASELLLGLAAQRGSLRYLLEWIEM
ALGASAVVHTMEKGKLLSSQEGMISFDCFMTILMQMRRSLGSSADRSQWREPTRTSDGLCSLYEAALCLFEEVCRMASDYSRTCASPDSI
QTGDAPIVSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLT
FEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDF
GRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALT

--------------------------------------------------------------
>36134_36134_3_HERC1-KIAA0101_HERC1_chr15_64045157_ENST00000443617_KIAA0101_chr15_64658274_ENST00000559519_length(transcript)=2460nt_BP=1990nt
CCTCTGCGGAGCCGGGCTCGGGTCGCCGGAGCCGCGCCCCACCCCGCCAGCTCCAGAGCCACGACTAATGGCTGAAGGATAAATCAACAT
GGCAACTATGATTCCACCAGTGAAGCTGAAATGGCTTGAACACTTGAACAGCTCCTGGATTACAGAGGACAGTGAATCTATTGCTACAAG
AGAGGGAGTTGCTGTTCTGTATTCTAAACTGGTTAGCAATAAGGAAGTAGTACCTTTGCCCCAACAAGTTTTATGCCTCAAAGGACCACA
GTTGCCAGACTTTGAACGTGAGTCTCTTTCAAGTGATGAGCAGGACCACTATTTGGATGCCCTTCTTAGCAGCCAGCTAGCATTGGCAAA
GATGGTATGTTCAGATTCCCCATTTGCCGGGGCACTTAGAAAACGACTGCTTGTACTCCAGCGTGTCTTTTATGCACTTTCTAATAAATA
CCATGACAAAGGCAAGGTGAAGCAGCAGCAGCATTCTCCGGAGAGCAGTTCTGGTTCAGCAGATGTCCATTCTGTTAGTGAACGCCCCCG
GTCAAGCACTGATGCACTTATAGAAATGGGTGTTCGAACTGGTCTAAGTTTATTATTTGCGCTTCTAAGACAAAGTTGGATGATGCCTGT
GTCAGGACCTGGTCTCAGTCTTTGCAACGATGTCATTCATACTGCAATTGAAGTTGTGAGCTCTTTGCCACCATTATCATTAGCAAATGA
AAGCAAGATTCCTCCTATGGGCTTGGACTGCTTATCGCAAGTAACAACATTTCTTAAAGGAGTCACTATTCCTAATTCTGGGGCAGACAC
TTTAGGTCGTAGATTAGCTTCTGAGTTGCTGCTTGGTTTGGCAGCTCAACGAGGCTCATTGCGATATCTTCTTGAATGGATAGAAATGGC
TTTGGGGGCTTCGGCAGTTGTACACACCATGGAGAAAGGCAAACTACTCTCAAGCCAGGAAGGAATGATCAGCTTTGACTGCTTTATGAC
CATATTAATGCAGATGAGGCGTTCTTTGGGTTCATCTGCTGATCGGAGTCAGTGGAGAGAACCAACCAGAACATCGGATGGCTTGTGCTC
CCTTTACGAGGCAGCATTATGTCTCTTTGAAGAGGTTTGCAGAATGGCTTCTGATTATTCGAGAACATGTGCTAGCCCAGATAGCATTCA
GACTGGTGATGCTCCCATTGTCTCCGAAACCTGTGAGGTTTATGTTTGGGGGAGCAATAGCAGCCATCAGTTGGTAGAAGGTACACAGGA
GAAAATACTGCAACCCAAACTGGCTCCTAGTTTCTCTGATGCACAGACCATTGAAGCTGGACAGTACTGCACTTTTGTCATTTCTACGGA
TGGCTCTGTTAGAGCTTGCGGGAAAGGCAGCTATGGGAGACTGGGCCTTGGAGACTCCAATAATCAGTCAACTTTAAAAAAGTTAACATT
CGAGCCTCACAGATCCATTAAAAAGGTTTCATCTTCTAAAGGATCTGATGGTCACACTTTAGCCTTTACGACAGAAGGAGAAGTCTTCAG
TTGGGGAGATGGTGATTATGGGAAACTGGGGCATGGAAATAGTTCAACACAGAAATATCCCAAGCTTATTCAGGGACCTCTACAAGGAAA
GGTAGTTGTTTGTGTGTCAGCTGGATACAGACATAGTGCTGCTGTCACAGAGGATGGGGAATTATACACATGGGGTGAAGGAGACTTTGG
AAGATTAGGTCATGGTGACAGCAATAGTCGTAACATTCCAACATTAGTAAAAGACATCAGCAATGTAGGAGAGGTTTCTTGTGGCAGTTC
ACATACTATTGCTCTGTCTAAAGATGGGAGAACTGTATGGTCTTTTGGAGGAGGAGACAATGGTAAACTTGGTCATGGTGATACCAACAG
AGTGTATAAACCTAAAGTTATTGAAGCTTTACAAGGAATGTTCATTCGCAAAGTTTGTGCTGGGAGCCAGTCTTCACTTGCTTTGACATC
AACAGGGCAGAGCATGTCCTTTGCAACCTGATCACACAAATGATGAAAAAGAATAGAACTTTCTCATTCATCTTTGAATAACGTCTCCTT
GTTTACCCTGGTATTCTAGAATGTAAATTTACATAAATGTGTTTGTTCCAATTAGCTTTGTTGAACAGGCATTTAATTAAAAAATTTAGG
TTTAAATTTAGATGTTCAAAAGTAGTTGTGAAATTTGAGAATTTGTAAGACTAATTATGGTAACTTAGCTTAGTATTCAATATAATGCAT
TGTTTGGTTTCTTTTACCAAATTAAGTGTCTAGTTCTTGCTAAAATCAAGTCATTGCATTGTGTTCTAATTACAAGTATGTTGTATTTGA
GATTTGCTTAGATTGTTGTACTGCTGCCATTTTTATTGGTGTTTGATTATTGGAATGGTGCCATATTGTCACTCCTTCTACTTGCTTTAA

>36134_36134_3_HERC1-KIAA0101_HERC1_chr15_64045157_ENST00000443617_KIAA0101_chr15_64658274_ENST00000559519_length(amino acids)=640AA_BP=
MATMIPPVKLKWLEHLNSSWITEDSESIATREGVAVLYSKLVSNKEVVPLPQQVLCLKGPQLPDFERESLSSDEQDHYLDALLSSQLALA
KMVCSDSPFAGALRKRLLVLQRVFYALSNKYHDKGKVKQQQHSPESSSGSADVHSVSERPRSSTDALIEMGVRTGLSLLFALLRQSWMMP
VSGPGLSLCNDVIHTAIEVVSSLPPLSLANESKIPPMGLDCLSQVTTFLKGVTIPNSGADTLGRRLASELLLGLAAQRGSLRYLLEWIEM
ALGASAVVHTMEKGKLLSSQEGMISFDCFMTILMQMRRSLGSSADRSQWREPTRTSDGLCSLYEAALCLFEEVCRMASDYSRTCASPDSI
QTGDAPIVSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLT
FEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDF
GRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HERC1-PCLAF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HERC1-PCLAF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HERC1-PCLAF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHERC1C4310766MACROCEPHALY, DYSMORPHIC FACIES, AND PSYCHOMOTOR RETARDATION3CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneHERC1C0004238Atrial Fibrillation1CTD_human
HgeneHERC1C0235480Paroxysmal atrial fibrillation1CTD_human
HgeneHERC1C2585653Persistent atrial fibrillation1CTD_human
HgeneHERC1C3468561familial atrial fibrillation1CTD_human
TgeneC2239176Liver carcinoma1CTD_human