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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BTRC-HIF1AN (FusionGDB2 ID:HG8945TG55662)

Fusion Gene Summary for BTRC-HIF1AN

check button Fusion gene summary
Fusion gene informationFusion gene name: BTRC-HIF1AN
Fusion gene ID: hg8945tg55662
HgeneTgene
Gene symbol

BTRC

HIF1AN

Gene ID

8945

55662

Gene namebeta-transducin repeat containing E3 ubiquitin protein ligasehypoxia inducible factor 1 subunit alpha inhibitor
SynonymsBETA-TRCP|FBW1A|FBXW1|FBXW1A|FWD1|bTrCP|bTrCP1|betaTrCPFIH1
Cytomap('BTRC')('HIF1AN')

10q24.32

10q24.31

Type of geneprotein-codingprotein-coding
DescriptionF-box/WD repeat-containing protein 1AE3RSIkappaBF-box and WD repeats protein beta-TrCPF-box and WD-repeat protein 1Bbeta-TrCP1epididymis tissue protein Li 2apIkappaBalpha-E3 receptor subunithypoxia-inducible factor 1-alpha inhibitorFIH-1factor inhibiting HIF-1factor inhibiting HIF1hypoxia inducible factor 1 alpha subunit inhibitorhypoxia-inducible factor asparagine hydroxylasepeptide-aspartate beta-dioxygenase
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000370187, ENST00000393441, 
ENST00000408038, ENST00000493877, 
Fusion gene scores* DoF score9 X 5 X 8=3604 X 3 X 3=36
# samples 94
** MAII scorelog2(9/360*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: BTRC [Title/Abstract] AND HIF1AN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBTRC(103190209)-HIF1AN(102296168), # samples:2
Anticipated loss of major functional domain due to fusion event.BTRC-HIF1AN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BTRC-HIF1AN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BTRC-HIF1AN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BTRC-HIF1AN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBTRC

GO:0000209

protein polyubiquitination

12820959

HgeneBTRC

GO:0006511

ubiquitin-dependent protein catabolic process

15448698

HgeneBTRC

GO:0016567

protein ubiquitination

16885022|18354482

HgeneBTRC

GO:0042752

regulation of circadian rhythm

15917222

HgeneBTRC

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

15917222

TgeneHIF1AN

GO:0036138

peptidyl-histidine hydroxylation

21251231

TgeneHIF1AN

GO:0042264

peptidyl-aspartic acid hydroxylation

21177872

TgeneHIF1AN

GO:0042265

peptidyl-asparagine hydroxylation

12080085|12215170|14734545|21177872

TgeneHIF1AN

GO:0045663

positive regulation of myoblast differentiation

18299578

TgeneHIF1AN

GO:0045746

negative regulation of Notch signaling pathway

18299578

TgeneHIF1AN

GO:0055114

oxidation-reduction process

12080085|12215170

TgeneHIF1AN

GO:0061428

negative regulation of transcription from RNA polymerase II promoter in response to hypoxia

11641274


check buttonFusion gene breakpoints across BTRC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across HIF1AN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-BP-5202-01ABTRCchr10

103190209

-HIF1ANchr10

102296168

+
ChimerDB4KIRCTCGA-BP-5202-01ABTRCchr10

103190209

+HIF1ANchr10

102296168

+


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Fusion Gene ORF analysis for BTRC-HIF1AN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000370187ENST00000528044BTRCchr10

103190209

+HIF1ANchr10

102296168

+
5CDS-3UTRENST00000393441ENST00000528044BTRCchr10

103190209

+HIF1ANchr10

102296168

+
In-frameENST00000370187ENST00000299163BTRCchr10

103190209

+HIF1ANchr10

102296168

+
In-frameENST00000393441ENST00000299163BTRCchr10

103190209

+HIF1ANchr10

102296168

+
intron-3CDSENST00000408038ENST00000299163BTRCchr10

103190209

+HIF1ANchr10

102296168

+
intron-3CDSENST00000493877ENST00000299163BTRCchr10

103190209

+HIF1ANchr10

102296168

+
intron-3UTRENST00000408038ENST00000528044BTRCchr10

103190209

+HIF1ANchr10

102296168

+
intron-3UTRENST00000493877ENST00000528044BTRCchr10

103190209

+HIF1ANchr10

102296168

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000370187BTRCchr10103190209+ENST00000299163HIF1ANchr10102296168+13008274641146360
ENST00000393441BTRCchr10103190209+ENST00000299163HIF1ANchr10102296168+12969235251107360

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000370187ENST00000299163BTRCchr10103190209+HIF1ANchr10102296168+0.0002702540.9997297
ENST00000393441ENST00000299163BTRCchr10103190209+HIF1ANchr10102296168+0.0002689550.999731

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Fusion Genomic Features for BTRC-HIF1AN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
BTRCchr10103190209+HIF1ANchr10102296167+9.28E-080.9999999
BTRCchr10103190209+HIF1ANchr10102296167+9.28E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for BTRC-HIF1AN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:103190209/chr10:102296168)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHIF1ANchr10:103190209chr10:102296168ENST0000029916308142_31259350.0DomainJmjC
TgeneHIF1ANchr10:103190209chr10:102296168ENST0000029916308181_18359350.0RegionSubstrate binding
TgeneHIF1ANchr10:103190209chr10:102296168ENST0000029916308201_20359350.0RegionSubstrate binding
TgeneHIF1ANchr10:103190209chr10:102296168ENST0000029916308238_23959350.0RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBTRCchr10:103190209chr10:102296168ENST00000370187+215128_177521939.6666666666667RegionNote=Homodimerization domain D
HgeneBTRCchr10:103190209chr10:102296168ENST00000370187+215190_228521939.6666666666667RegionNote=Required for down-regulation of SNAI1
HgeneBTRCchr10:103190209chr10:102296168ENST00000408038+114128_17701918.3333333333333RegionNote=Homodimerization domain D
HgeneBTRCchr10:103190209chr10:102296168ENST00000408038+114190_22801918.3333333333333RegionNote=Required for down-regulation of SNAI1
HgeneBTRCchr10:103190209chr10:102296168ENST00000370187+215301_338521939.6666666666667RepeatNote=WD 1
HgeneBTRCchr10:103190209chr10:102296168ENST00000370187+215341_378521939.6666666666667RepeatNote=WD 2
HgeneBTRCchr10:103190209chr10:102296168ENST00000370187+215381_418521939.6666666666667RepeatNote=WD 3
HgeneBTRCchr10:103190209chr10:102296168ENST00000370187+215424_461521939.6666666666667RepeatNote=WD 4
HgeneBTRCchr10:103190209chr10:102296168ENST00000370187+215464_503521939.6666666666667RepeatNote=WD 5
HgeneBTRCchr10:103190209chr10:102296168ENST00000370187+215505_541521939.6666666666667RepeatNote=WD 6
HgeneBTRCchr10:103190209chr10:102296168ENST00000370187+215553_590521939.6666666666667RepeatNote=WD 7
HgeneBTRCchr10:103190209chr10:102296168ENST00000408038+114301_33801918.3333333333333RepeatNote=WD 1
HgeneBTRCchr10:103190209chr10:102296168ENST00000408038+114341_37801918.3333333333333RepeatNote=WD 2
HgeneBTRCchr10:103190209chr10:102296168ENST00000408038+114381_41801918.3333333333333RepeatNote=WD 3
HgeneBTRCchr10:103190209chr10:102296168ENST00000408038+114424_46101918.3333333333333RepeatNote=WD 4
HgeneBTRCchr10:103190209chr10:102296168ENST00000408038+114464_50301918.3333333333333RepeatNote=WD 5
HgeneBTRCchr10:103190209chr10:102296168ENST00000408038+114505_54101918.3333333333333RepeatNote=WD 6
HgeneBTRCchr10:103190209chr10:102296168ENST00000408038+114553_59001918.3333333333333RepeatNote=WD 7


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Fusion Gene Sequence for BTRC-HIF1AN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10564_10564_1_BTRC-HIF1AN_BTRC_chr10_103190209_ENST00000370187_HIF1AN_chr10_102296168_ENST00000299163_length(transcript)=13008nt_BP=274nt
AGAGGTAAGAGAGGGCGGGGGGAAGGAAGAGGAGGCGGGATCCGGGCGCTGCGTTGGCTGCGGCCTGGCACCAAAGGGGCGGCCCCGGCG
GAGAGCGGACCCAGTGGCCTCGGCGATTATGGACCCGGCCGAGGCGGTGCTGCAAGAGAAGGCACTCAAGTTTATGTGCTCTATGCCCAG
GTCTCTGTGGCTGGGCTGCTCCAGCCTGGCGGACAGCATGCCTTCGCTGCGATGCCTGTATAACCCAGGGACTGGCGCACTCACAGCTTT
CCAGGAGCCTGTGGTGCTGACCGACACAAATCTTGTGTATCCTGCCCTGAAATGGGACCTTGAATACCTGCAAGAGAATATTGGCAATGG
AGACTTCTCTGTGTACAGTGCCAGCACCCACAAGTTCTTGTACTATGATGAGAAGAAGATGGCCAATTTCCAGAACTTTAAGCCGAGGTC
CAACAGGGAAGAAATGAAATTTCATGAGTTCGTTGAGAAACTGCAGGATATACAGCAGCGAGGAGGGGAAGAGAGGTTGTATCTGCAGCA
AACGCTCAATGACACTGTGGGCAGGAAGATTGTCATGGACTTCTTAGGTTTTAACTGGAACTGGATTAATAAGCAACAGGGAAAGCGTGG
CTGGGGGCAGCTTACCTCTAACCTGCTGCTCATTGGCATGGAAGGAAATGTGACACCTGCTCACTATGATGAGCAGCAGAACTTTTTTGC
TCAGATAAAAGGTTACAAACGATGCATCTTATTCCCTCCGGATCAGTTCGAGTGCCTCTACCCATACCCTGTTCATCACCCATGTGACAG
ACAGAGCCAGGTGGACTTTGACAATCCCGACTACGAGAGGTTCCCTAATTTCCAAAATGTGGTTGGTTACGAAACAGTGGTTGGCCCTGG
TGATGTTCTTTACATCCCAATGTACTGGTGGCATCACATAGAGTCATTACTAAATGGGGGGATTACCATCACTGTGAACTTCTGGTATAA
GGGGGCTCCCACCCCTAAGAGAATTGAATATCCTCTCAAAGCTCATCAGAAAGTGGCCATAATGAGAAACATTGAGAAGATGCTTGGAGA
GGCCTTGGGGAACCCACAAGAGGTGGGGCCCTTGTTGAACACAATGATCAAGGGCCGATACAACTAGCCTGCCAGGGGTCAAGGCCTCCT
GCCAGGTGACTGCTATCCCGTCCACACCGCTTCATTGATGAGGACAGGAGACTCCAAGCGCTAGTATTGCACGCTGCACTTAATGGACTG
GACTCTTGCCATGGCCCAGGAGTCAGGTGTTTGGAGCGAGGCAGGGCAGTTGGCACTCCACTCCTATTTGGAGGGACTTCATACCCTTGC
CTCTTGTGCCCCAGCACCTTCTCTCTCTGCCCCCCGCCTAAAGTCCTGCATTCAGTGTGTGGAGTCCCAGCTTTTGGTTGTCATCATGTC
TGTGTGTATGTTAGTCTGTCAACTTCGGAATGTGTGCGTGTGTGTGCATGCACACGCATGTATGTATCTGTTCCCTGTTCCTTCTGGGTC
AGGCTGTCACTTCCGGCTCTCAGCCCTATCTCCTGCAACCTCAGTGCCTCAGCCTGAGAGAGAGATGAGATGCTCTTGGACTCCCCACTG
CATCTGGGCTGCAGGGCCAGAGCTAGTCTGACCATTAGGTCAGTCTGCCTCCTGACAGTTTTTGCGTAGTCAAGCTCTAGGCGGTATGGG
AATGGCTACCGGGACTCTAATGGGGTGAAAGAGAGGGGAGGCTTGCCTTTGAGAGCCTATATAGCCTTCCTGTGAGAGAGGATTAGATAG
GGTTCCAACTGGGCCTACAAGCTCAAGCCATACATAAAAGGACCTTGGGACATAAGAACCAATGATTGTGCATAAGTTCTAAATTAGAGA
CACATATAGTTTCTCTCTTTCAGCACCAGCTCTTGCCCCTATGCTGGGTACCAAGGGAGTTCTCCTAGCTGTGGCTTCTCTAGGTTCTAG
GGGTGCAAGCCTCTGTGTGTTTGTTTGTGTGTGTCTGTGTGTGCGTATCCACACTAGGGGTGCAAGCCTCTGGGTGTGTGTGTGTGTGTG
CGTGCGTGTGTGTGTGTGTGTCCGTGTGTGTGTGTGTGTGTGTCCACACTGGCCAGCCTCCCTACTTACCAAGGTTCTCCACTGCTTACC
TTTTCCAGTGGGACAGTACAGTGTGAGCCCCCGGGAAGTACTGCCTGACCTATCCTAAGCTTTTACACTTGGATTTTAGCCATCATATGT
TGGCCAGGTCTCACTGCAGCCTGCCCGAGGCTAACTGGCTAGAGCCTCCAGGCCCTATGATGCTCCCTGCCCAGGCCATATCCTTTATTC
CTGCTGAGCTTCCTGGCTGAATAGATGAAATGGGGTCAAGCCCAGGCAGCTCATTCACTACCTGTGATCCACCTCAGGGCACGGGCAAAC
ACATAGGCTTGCGTCTTAAAGCCAGCTCCTCTGCCAGACCCCGTTGTAATGTGCCACAACACCCTCAATAGTCAGGGCAACTGGTGGAGC
ATGGAAGTCGAATTTCCTTTTCTGTTAGGAGCTACTCCTGGGAACCCCTCTCAGGGCTGCAGCTTACAGGTGGGCAGCTGTGATTGCACA
ACTTGAAGGGCCATCATTCACATCTATTCAGTGGGAGTGGGGTCCCTGGGATTGGGCAGTGTGGTGGCCCTGTGTCTCCTCACCTCTGCT
CCTGTCTTCATCACCTTCTCTCTGGAAGGGAAGAGGAGTTGGAAGGTCTCTGGTTTTCTTTTCTTTTTTTTTTTTTTTGCCAAAGGTTTA
CTTCCAGCATCTGAGCTCTGGCTCTCACCCCTGAAGCTCAGTTATAGTGCACTGATGAACTGAGAGGATGCGTGTGGATGTGTGTGCATG
CCTGAGTGCGTTTTTTGGGGAGGGGTGTTTATTTTTAGTACCCCATTCTGGGGTTCTCTGATGCAGTGTGGATGTGAAGATATGGTACCT
TCTCAAGTGTAGCTCTTTCAAATATAGTCAATGCTGGGAAATGTGATTGCAGTGATCTCTATCTCTCCACTTCTTTTGGGAAAGAGGAGC
ACAGGAGCGGAGGAAAAACTTGGCCACAGTCACACTTGGAAAGATAGTAGATTATTTTCGTTCTCCTCAGCAGGTCTGCTGTATTCCTCG
CTCAGCGCTCAAAGATGTGGGTGATGTGTCAAGGAGGCATGCACTCAGCTGGTCCTTGCTGAGTTATTTGCTGACACAGGTCTCACTAAG
GTGGCTGAGGGGTGGGAGGGAGAAGGCTAATCTTGGAACCTTCACAGGATTGGCCTTGATCCTTGGGTAACACAAGAGTGATTCCTGATT
TTTAGACACCTAATATGTGCCTAGTGCTTTTCTCTTTGTTCCTCACTATCCTGCAAGGTAGGTATTCTCACTTACAGATGAATAAATGGG
CTCAGAGAGATTAGGTGATTAGTGACAATCAGTTGTAACTTAGCACTGTTAGGCTGCAAACCCCTTGCTCCTTCCTTTCCACCAAACTAT
GTTGATTTTCCTTCCTTACCTCCCTCCTTGTACCACAGGTTCTGTCCTCAAGATATCACCCCACTGGGCAGTATCTGAAGGCAGACCCAG
CCCAAGATGGTGCAGAATATACAGCTCAGGGTGAAAGTTCTTCTGGGCTCCTGCTAACAAAGTCTTGGAAAAACTGCCTGGGAAGCCATA
TTATGAATTAGTGCTAGAAGAAGCTGTGGGGGGAACTGAGTTCTGTGTCTAATTGCATTACTTATGTGTCCTTGAATAGGACCCATAACT
CCTCCCGGCATGCTTTTGCATCTATAGAACTGAAGCTGTAGTTCTAGATGGCACTAAGGGTCTTGGTTCATATTCAGCTGCTGCTTCCCC
CCAAGGAAAAGATGAGGTTTTTCCCCTTCGATTACCTTTTGAGGGATGTTTAGGCTCAAATTCTGCTTGCCACAGAGGAAACATTTCTGC
TGTAGTTGTTTACCTCCATCCTAGCTGGCAGTGTGGGACACACACATACAGCAAGTGAAGGTGGGGGTTTGGGCCTGTATAGAGGTCAGC
TACGCTGCAGGCTCATCTATTCACACCAGCAGGTACAGAGAAAACTAGTGTTTTGTAAAGTCAAATATTTGTTGGGGGTTGGAGTTCTGG
GGTTGGAGGAGGGGCTGTTCTGGGCATCAGTTGAGCAGATGCCCAGGATGCCTGGGGGAGACCAGCTTCCCCTACAAATCAGAGCTCTAA
ATTACAAGGTTTTTACCAACGTGAACAGTTGGGGGAAGTCGTCTGCTCTCATTTGCGTAATGGTTTCTGTCACTGGTGATTAGACACAGG
ATGAAGGAAAAGAAATTTGACAATTAGGAATGAGCGATCATTAATCTGAATCTGTTAGGAGACAGAGAGGGGAAGGATCCTTATCAGTGG
GCCAGCCCAGTATGGGGAGACACTCCCTCCCTCTGCCCCCAGAGACTCCTGGGCTACATCCTCTTTCAGTATTGCCACAAGTGGGCAGAG
CTTGTATTTCTTAACAAAGATTAGGGACCCAGTTGCCAGCCTGAGATGGATATAGGAACAGACATCTTTGGGCATGAGCCAACAAAGATA
GAAATAGATGAGTGTCAGGTACAAGCTATAAGGCAAAGAATAACAGTGGAAAAGTTTTGACATGTGTTTGCCATTTGTGGAAAATGTTTT
TGTAATAGTCAACACCCCTCATAGCCCACCTGTGACAAGTACTTGTTACATTCCAGCACTGTAGGGCGTGAGGAAAATCTGGTCCTTATC
AAATCCCAGGAGCTTCTGCTTAGTTGGGGAAGAAATTACATGAAGCAACCAGAGGTTATAAGGCCACACTTGTATATCGTGCACCCTGTG
TGGACAAGATTAGGGACTGTTGAGAGAGGAGGAAACCAGTAGAGAGCAAAGCTCTACCCAGGCTCCTTGTAAGCCTCTGGGCTCCCCCGA
GAGGGCCTCGCTACTCTACGCTTCCTAGCAACGTTGATGTCCCCACAACCCCACATCAGTGCAGCTGTGGCTGTGTGGAGGGGCTCTGAG
GCCTCTGAGGCCAGATGTGTAAACAGTGCTGAGGTTCAGTAATAGGATGAGTCTTCAGGTGTGGAGCAGCCCACCTTGGCTCTTCCCATG
TCTCTGTGTTACTTCTCATATTCTGCTGTCCTTTCAAACTTCAAGGACAGTATTAATTTATACTAGTATTTCTTCCTCAGTTTTGTGACT
TGAATGCAGTGAGTGCCTTAGAGGATCCAAGGATGAAGGAATGCGGGTTGGTGGTTCTCTCTTTCAGAATGGGAACTTCCCAAAAATGGG
GCTGCGTCTCGCCTCTCAGTAGGTTCCCTACCTCTGGGTCTTCCACCCTTCAAAATCTGGTACAGAATTTAGCAGGGGCTGCAGGGAATG
ACCCTCAGGGACCAGTTTCACCCAGATGGGGTAGATGATGAGGTATACCTAGAAGTAGCTCAGGGCTCCAGAGTCTGGCCTTTCAGCTGG
TGTCTTACTCCCCTTTGAGACCTTCAGCTGCTTGTCTTCCACTGCCTGCATACTTCTCTGATGTCTTCTCAAACTGTTGGCTCTAAAGGG
ATGTTCCAGCCTCCCTCTCCAGAGCTGCCTGCAGTTTCCCTTATTCAGCTGTCTCCTGCCTAGTCTCTCCAGCGGCCTCCTTACCAAGAC
CCTTTTTCCTAAACAGTTGTCCTTCCCTCAGAAACTCCATGGCTGCAAGTGTGAATAGACTTGTCTTTAGGATCCCTCTCTCTGGTCATC
CCTGATCATCTTAGGGCCGTCTCCCTTTTCTGATTTTTGACAGCTCTGTTTATTTTGCCCATGGCTAGTCCTCTTGTTTTGTGTCTGCTG
TGTGTTCTTGCCCTTCCATTGTCAGTTCTGTACATCCTGGTTCAGCTTGTCTCACTGTGGTAGCCCCTTCTGCTTGTCTTCAGCCATCTT
GGTTTAATCCTCATAGGTCATGGATGAATGGAGCCTTGCTGAGCACTTTGAGGGCATTTCTGTTGGGCACAACCTCAGAAACGGGAAGTC
TTGAGGCCTGGGGGCGTGTGGTCAGTGAGGCCTCCAGAGGTGGGTTAGGGGTGGGCACCTACAAGGGCCAGTTGAGGGGAGAGGTGCAGG
GATTGCTGAGGAGACTTTGTGAGAATGATGTCAGGCCCGGGAAGCTGGTGTGGAAGAACTGAGCTGTCAGAAGGAGATACCAATATCCCC
TTTGCAGGGTGGTGATGGGCATCAAACATGACGTGGAACATGTCCCCTTCATGGAGGGTTTCCATCTAAATGCATCTGTGTGCCTTAGGG
ATCAGTAGTTCAGGGGTGGTGGACTTTTTTGAGTGTCTCCTAATTTCTCTGAGGTGTCTTTGGCTCTGTGTCACCAAATGTGCCTGACCT
CTGCATCCCAGTGGTTGCTGAAAGGGAAACAGTATATTGCGTAGTCAGATGTCAGGAGTAGAGATCTTAATGAGAAAGGCCCTGGCAGCT
GGAGAGATGAGAGGACCTAGTGGTCAGCTTATACCCAGACTATCTCTCCACTCCTCCAAGAGTTTGAGTCCCATAGCTGATGAAAGAATT
TACATATGGGCTCCCCCCTGCTTTCCCACTGAAAATCTATTCTCATATTTTGGGAAGGAGCATATGTCCTTTAACTTTCAATGGTAAACA
ATCTAGGATAGTGTTTAAAGGCATGGATTTTGGAGTCACATATAGTTGGTTTGAATTTCTAGCTTCACTACTTACCAGCTGGGTTTGACC
TTGGTTGATTTACTTAACCTCTCTGAGCCTCAGTTTCCTCAACTATAATAACATGGGTGGAGGGAGGCATGTTGAAAATATCTACCTCAG
GGTTGTTGGAATAACTGAAACAATGTTTGTAAAGCTTTAGCACAGTGCCTGGCAAGCACTTAATAAATGGCTGTGGTGGTGGTGGTTATA
TTTATTATGTGATTTATTCAGAAACTTGGTTTCAGTGATCTCTAAACAGATTTCCAGTGGTTCTTTCTCTCTCAAGAAAAGCATAGGGAA
AAACGAGAAACACCTTAGATAAACCATATTGAGTTGAGGGTAGACAGAAGAGTCTAGTACCTAAACTCACCCTAGAGGAAGAGAAACAGG
AAGTGTCTTATGCCTCTTCTGCCTGGGCAGCCAGACTTTACTGCTGTACTACCAGCCCAGGGCCTTGGGTGAGAAGGTTTCAGGTCTGAG
CTCCCCTTGCACTGTGTGAGAGGCCGTGGAGCCGAATGAGTCCTTATTATACCTGGAGAAGCTGTTGTCTCCTCACACCATGAAATGTAA
TAGCAGTCAAATCAGGCCCCTCTTGATTCAATTTTAGTCCATGCCTTTCCATGTATTTAAATTATATAAGTGTTGGCCAGGTGTGGTGGC
TCACACCTGTAATCCCAGCACTTCGGGAGGCTGAGGCAGGAGGATCACTTGAGCCCAGGAGTTCGAACCAACCTTGGGCAGCATAGTGAG
ACCCCTTCTCTTAATAATTTTTTTTGAAAATAATTTTTTAAAAATTACAAATATGGACCAGACACCTGGGAGGATTACCTCACGCCTGTA
ATCCCAGCACTTTGGGAGGCTGAGGTGGGTGGATCACCTGAGGTCAGGAGTTTGAGACTATCCTGGCCAACATGGTGAAACCCTGTCTCT
ACTAAAAATACAAAAATTAGCCAGATGTGGTGGTGGGTACCTGTAATCCCAGCTACTCGGGAGGCTGAGACAGGAGAATCACTTGAACCT
GGGAGGCGGAGGTTGCAGTGAGCTGAGATCACGTCATTGCACTCCAGCCTGGGTGACTACAGTGAGACTCCCTCTCAAAAAAAAAAAAAA
AAAATTATGAGTATGTTAAGATTGTTCTAGGGGAGAAGGGCAATCAAAATTCAGAAAAATATGAGTGGGATGTTAATAGCTACCATTTGT
TGAACACTTCTGTTCCAGGCACTGTATTAGTTCGTCCCCATGTGGTGCTCTCAGATCAGTAGGGGAGACAGGCAGGCAGTTAGAATTATG
GTGTATAGAGGAGAAGCATTGCACTATGTCCAGTTTTTTATGGTAGGCTTCCTGCAGAAAGTGATAAGTCCAAGCTGATATGTGGAAGAT
GAATAATTAACCAGAGGTTGGGGGATTTCCCCCTTAGCTTCTCTTTCTTCCAGTCCAGCAGTCCAAAACAAACACTGCTTCCCAATGCCT
AAGGGTTTTGTCGTACCTTACTCCAGGGAATGGGTGAGACAGTAGATCCCAAGAAGAAAACCCTTTGGTTAGTCACAGAAATCTGAAAGT
CTTGGTTGCTGGCTCAGATTTGTCCTGGAGTGGACGTAGATTGGACTTGCTTATTTGTAGCCCTCCACCGTTCTCATTTGTGTTCTGGCC
TCTGGAGCCACCCTGCCAGACCCTACTTGGAAGAAATGTTGAATCAAGCTACTCAGACTTCAGCCTGAGATGTATTATGGCTGGCTGGAA
TTCTCAGCCCTTTCCACATCATGATCCCATTAATCTCTTGGGTCTATCCCCACGCCCAGCCACCTCTCCTCCTCACTATAAGCCAAGTCT
CCCTGCAGTTCTCTATAAATACTCAGATCCTCTTGCCTCAGACCCTGGTCCCTAGCTTTGTGGGTGAAGAAGATACCTCTTTAGCTTGTG
CCAACCCATCCCTCTGGGCTACAGGCCATTCTGTAGTCACCTTGCAGTCACGTCTTTCCTTCTAGATAACTGGCTCTGGGCCTTGGAAAC
CTTCTCTTTGGCTCTAGCTAATTTTGCTGTTTTATTCCGTTTACTTAAAACCTATTCACTTGGTCATTGAGGTCAGAACTATCAGGAAAG
CTGTGCTCCTTAACCCATCATCTAAGCTAAGCTTGGGCCAGGTTTTTATTACCTCTTGAATATATATAGTGCAATATAGTGTAGTGGTTG
AGAGTGGAGTCTGCATACCTGGATCTGCCATTCTGCATGACTTTGGGCAAATGGACAAACTGCCCGAAACTTGACTTGTTTATATGTATG
GGGAAGACATCATTTACATTGTCAGGGTAAGGCTTAGCAGAATGACCGGTCCATAGCAAGGGCTCAGTCTTTCTGTGTCTCTCAGTCTTT
ACCTCTCTTCCCCATCTAGCTTTCTGTCTAAGTTCCTGTTTCTAGTCTCAGGGCATATCTAGTTGTCAGCTCCTGAGCAGAGCAGAGGTA
TAAGTGTCAACTCATGCTTGTGTTACCAGTTCCTACCCCTGTCAGTAACCTCTGATGCTTACAAGGATACTATCACCTATGCCATCAGTG
GGGAATGACCTTCCAAAAATATTTTTAACAATACTAAAAATACCTGAAACATACTGGGTGAAAATAAGACATTGGAGCTGCTGCTCCCCA
AGGAGATAAAAGGACAGTTCCTAAAGAGGCATTGAAGGTTTGTATGAGCCAGCAGCACAGTCAGAAGGCAAGAAGGAGACCCTGGGATGT
GCACAAGGATGCAGGAGACGAGATTGTCACAGAGGCTGTCATGCTAGTAAGAGTCAGAGGTTACTGATGGGTAGAGATTGTCAGAGTCTG
CCTTGCTAGTCTAGAGGTAGGACCATGGATTTAAGAACGTTGCCTCCAAGTTTTTGAATTGTGAATTTTTGATCATATTTGAACAAAACC
CCACCTACAGTCTGCATGGTCATTGTTCTCACAAGGGTTTGTGTGATGCACTGACAAGAACAGAGGCTTTGGAGGTGACTCCTGGGTTTG
AATCACCATTTGCCACTAGCTAATTCTAACCTTAGGTAAGTCAGTGTCTCTGGGTCTCAACCTCTTCCTCTGTGAGGGGTAGGAAATAGC
ACATAACTTGTAGCATTGTTATAAGGGCTCGTGATAATGTTTTTAAAACACCTGGCTCAAGCACTCAGGAAAATGTTTTATTATGAAGAC
CAAGTGTCTCTGAAAAGTGTTTCCTTAGTGTCTGGAGAGACTACAGCAGCAAGGCTTTTCTGATCCTACTCTGACTCTCAAGATAATGGT
GCTTGAAGTGAAATCACAGAAGAGATGACTGGGGCAGGAAAAGCAAGATGGAAAAGATAAAGTTGTGGAAGGGACTGAAAGTCCATGAAG
TGCTGGGCTGGGGACAGAAAGGGTTTAATAGGGCAGGGTCTTGAGGAACAGGAACAGAGACCTTGGTTCTGGGTTGCCATCTGATTCCCA
GAAGAGTAAAGGAAATGGGGCAGGAGGATGTCTGTGGAGGACACAGTGTGGCTGAGTGGAGAGAACACAAGCTTCTGGCCAGTGAACCTA
AGTGAGAATGTCAGTGGACTTTGCACAGGCTGGGTGCCTTTGGGGGTGTTCATCTCGCTATGCTTCGGTCCCCTCATTTAAAAAAATTGG
TTAATAATATGATGACCTGCCAATGTGTGTGGAAATACTATGTAAACTGAGCACTATATAAATGCTGGTTGTTGAGATATTGGGAGTGGG
GGTTTCGGGAGATTTTGTTTGTTTGTTTTTTTGAGATGGAGTTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTTGGCTC
ACTGCAACCTCCACCTCCTCCAGGTTCAAGCAATTCTGCCTCAGCCTCCCGAGTAGCTGGGACTCAGGCGTGCGCCACCATGCCTGGCTA
ATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCTGCCTTGGCCT
CCCAAAGTGCTGGGATTACAGGTGCGAGCTACCACACCTGGCCCTGGATTTCTTAATAGGTCCTCTTATGTGGCTATTGAGAATGAATGA
GACAACTCATTAACTAACTAAGTTAATTCAGAACTTAGTGCCTAGTAAGTGCTCAGTAAATGTTAGTTTCTTTTCCTCCATTTCTTCTTA
GGAAGCATCGTTTACCCAGCATAAACAGGAGGACTCAACTGTGCATGTCTTAGTGTGAACAAGTAACATCAGATTTCCCTTTTCTGAGGA
GAGATCAGTTCTGTAAGAGGGAGCATGAGTGTGAATGGGGAAGAATCATGGAGAAGGGAGCAGGACTCCACAGTACTGGAGATGGAGTAG
GGACCTCTGGGAATCGTTGGCATGGGGGTGTGGTGCAGAAAGGGTGATGCTAAGAGGTGAGAGTCTCAAGAAAGAAGATGGGTGTTCTAG
AGGGGAAAGCTAAACGATGATAGGCAATGAGGAGCGGAGGACAAGACCCTGAACTAAGGGTGAGGAGGCCAGCATTCTGTCAGGAGAACC
TTAGGAATTGTGACCAGAAGTCAAAGTTGTTACAGCAATCCTGCATTCAACCAGGTTTCATCTGAAAAACTTAAGAGTTGCTAGGCACAG
TCGTGCACACTTGTAATCCCAACACTTTGGGAGGCTTGAGTCAGGAGGAAGCTTGAGGCCAGGAGTTTGAGATCAGCCTAGGCAGCATAG
TGACACCCCATCTCTTGAAAAAACAAACACTCTTAAGAGCAGTGGTTCACCTAGAAATAAAAAGCAGAAATCATCAAGATGAGAAGACAT
TTTGTGTTTTGACAGCCAAGGAAATTTGCCACTGAGACAAGGTATCTGACAGCCTAGATGGGATTCTAGACTTCTGTGAGAAAGTGCAGT
TAGGCCCTGAATAGCGTCAAACTCAGGGATGTGAGCTGACTGACTGCCTTTTTATGTAATGGAGGCCATGTGATAGGGCTTTATGAGGCC
ACAAATAGCACTTTCTGGGTCCTTTCACAGTCTAGTCAGTGGCCCAACCAACATATCTGGTTGTTCTGCAATCTCAGTCATCTGAGAAGA
TAACCTCCAAAATACATGCAGTGGCATCAGGTGTTTCCTTGGTAGGTGTGCATCTTTTAATGATGGAGGACTTAGGATGAAGAACAGGTG
TGTTTAAAAACATCAAACCCCCACATCATTACTATTTGCTGTAAGGATCTATGCAGTTTGTATTTTAAGTCCTTGACATATGGAAGAGCA
TTTGTGAGAGTAACAGGTTTGCTTTGTAATGCCAACTAAAAAGTGTGTATTTATACTCGAATTTTAAGTTGAAATTTTGCTAAGTTTCTT
TTTTTTTTTTTTGAGACGGAGTCTCACTCTGTTGCCCAGGCTGGAGTACAGTGGTACAATCATTGCTAAGTCTTTCTGTAGTTTTAGAAC
ATTTAGAACAACTTAAGATTTCCTGTATTTATAAACTTAATTTATTGGAAATATAAGTACTTGATCAGGTTTTGTCTTGGTCAGATAAAT
TAAGTACTTAAGGAAATCAAATACATTAATCATATAAATGCCATTTAAGTGTTTAAAGGAGTTTAGTTAAATGTAAGTTGGATCAAACAT
TAAACTTTTTTGTTTTATAAGCAAAATAATAAGATTTGTTAGCAGAACTTAAAAGCTTAGAAAAGAGAGGATTTTGGATATGTAACTTTG
AAGAGGTGAATAGTTTGCTCTTTTCTGAGACAGGGCATTGCTTTTCGACGCAGGCTGGAGTGCAGTGGGGCAAGCATGGCTCACTGCAGC
CTCAACCTCCTGGACTCAAGTGATCCTCCTGCCTCAGCCTCCCATGTAGCTGGGATCACAGGCACATGCCACCACACCTGGCTAATTTTT
TATTTTTTGTAGAGACAGGGGCCTCACTTCATTGCCCAGGCGGATCTCGAACACCTGGGCTCAAGCAGTCCTGCCTCAGCCTCCCAAAGT
TCTGGGATTACAGGCATAAGCCACTGTGCCTGGCCTTGAATATATTTTTTAACCAAAGTAATTTATGAATATAAATTGTTTCTATATAAC
CCAAAGTCACTCTCATTGACATTAAGAAACTCAGAGAGTGGGTTCTAAATGTAATATTACCACACACCCAAGTCACTTAGCCTCTACAAG
TACCACGTAACTAGCAGCCGTTAAAAGATGGCCACCGCTAGTCCAGTCGGCCACAGACATGGTTTTGTTTGGCCAATACAAGTTTTTGAA

>10564_10564_1_BTRC-HIF1AN_BTRC_chr10_103190209_ENST00000370187_HIF1AN_chr10_102296168_ENST00000299163_length(amino acids)=360AA_BP=70
MAPKGRPRRRADPVASAIMDPAEAVLQEKALKFMCSMPRSLWLGCSSLADSMPSLRCLYNPGTGALTAFQEPVVLTDTNLVYPALKWDLE
YLQENIGNGDFSVYSASTHKFLYYDEKKMANFQNFKPRSNREEMKFHEFVEKLQDIQQRGGEERLYLQQTLNDTVGRKIVMDFLGFNWNW
INKQQGKRGWGQLTSNLLLIGMEGNVTPAHYDEQQNFFAQIKGYKRCILFPPDQFECLYPYPVHHPCDRQSQVDFDNPDYERFPNFQNVV
GYETVVGPGDVLYIPMYWWHHIESLLNGGITITVNFWYKGAPTPKRIEYPLKAHQKVAIMRNIEKMLGEALGNPQEVGPLLNTMIKGRYN

--------------------------------------------------------------
>10564_10564_2_BTRC-HIF1AN_BTRC_chr10_103190209_ENST00000393441_HIF1AN_chr10_102296168_ENST00000299163_length(transcript)=12969nt_BP=235nt
ATCCGGGCGCTGCGTTGGCTGCGGCCTGGCACCAAAGGGGCGGCCCCGGCGGAGAGCGGACCCAGTGGCCTCGGCGATTATGGACCCGGC
CGAGGCGGTGCTGCAAGAGAAGGCACTCAAGTTTATGTGCTCTATGCCCAGGTCTCTGTGGCTGGGCTGCTCCAGCCTGGCGGACAGCAT
GCCTTCGCTGCGATGCCTGTATAACCCAGGGACTGGCGCACTCACAGCTTTCCAGGAGCCTGTGGTGCTGACCGACACAAATCTTGTGTA
TCCTGCCCTGAAATGGGACCTTGAATACCTGCAAGAGAATATTGGCAATGGAGACTTCTCTGTGTACAGTGCCAGCACCCACAAGTTCTT
GTACTATGATGAGAAGAAGATGGCCAATTTCCAGAACTTTAAGCCGAGGTCCAACAGGGAAGAAATGAAATTTCATGAGTTCGTTGAGAA
ACTGCAGGATATACAGCAGCGAGGAGGGGAAGAGAGGTTGTATCTGCAGCAAACGCTCAATGACACTGTGGGCAGGAAGATTGTCATGGA
CTTCTTAGGTTTTAACTGGAACTGGATTAATAAGCAACAGGGAAAGCGTGGCTGGGGGCAGCTTACCTCTAACCTGCTGCTCATTGGCAT
GGAAGGAAATGTGACACCTGCTCACTATGATGAGCAGCAGAACTTTTTTGCTCAGATAAAAGGTTACAAACGATGCATCTTATTCCCTCC
GGATCAGTTCGAGTGCCTCTACCCATACCCTGTTCATCACCCATGTGACAGACAGAGCCAGGTGGACTTTGACAATCCCGACTACGAGAG
GTTCCCTAATTTCCAAAATGTGGTTGGTTACGAAACAGTGGTTGGCCCTGGTGATGTTCTTTACATCCCAATGTACTGGTGGCATCACAT
AGAGTCATTACTAAATGGGGGGATTACCATCACTGTGAACTTCTGGTATAAGGGGGCTCCCACCCCTAAGAGAATTGAATATCCTCTCAA
AGCTCATCAGAAAGTGGCCATAATGAGAAACATTGAGAAGATGCTTGGAGAGGCCTTGGGGAACCCACAAGAGGTGGGGCCCTTGTTGAA
CACAATGATCAAGGGCCGATACAACTAGCCTGCCAGGGGTCAAGGCCTCCTGCCAGGTGACTGCTATCCCGTCCACACCGCTTCATTGAT
GAGGACAGGAGACTCCAAGCGCTAGTATTGCACGCTGCACTTAATGGACTGGACTCTTGCCATGGCCCAGGAGTCAGGTGTTTGGAGCGA
GGCAGGGCAGTTGGCACTCCACTCCTATTTGGAGGGACTTCATACCCTTGCCTCTTGTGCCCCAGCACCTTCTCTCTCTGCCCCCCGCCT
AAAGTCCTGCATTCAGTGTGTGGAGTCCCAGCTTTTGGTTGTCATCATGTCTGTGTGTATGTTAGTCTGTCAACTTCGGAATGTGTGCGT
GTGTGTGCATGCACACGCATGTATGTATCTGTTCCCTGTTCCTTCTGGGTCAGGCTGTCACTTCCGGCTCTCAGCCCTATCTCCTGCAAC
CTCAGTGCCTCAGCCTGAGAGAGAGATGAGATGCTCTTGGACTCCCCACTGCATCTGGGCTGCAGGGCCAGAGCTAGTCTGACCATTAGG
TCAGTCTGCCTCCTGACAGTTTTTGCGTAGTCAAGCTCTAGGCGGTATGGGAATGGCTACCGGGACTCTAATGGGGTGAAAGAGAGGGGA
GGCTTGCCTTTGAGAGCCTATATAGCCTTCCTGTGAGAGAGGATTAGATAGGGTTCCAACTGGGCCTACAAGCTCAAGCCATACATAAAA
GGACCTTGGGACATAAGAACCAATGATTGTGCATAAGTTCTAAATTAGAGACACATATAGTTTCTCTCTTTCAGCACCAGCTCTTGCCCC
TATGCTGGGTACCAAGGGAGTTCTCCTAGCTGTGGCTTCTCTAGGTTCTAGGGGTGCAAGCCTCTGTGTGTTTGTTTGTGTGTGTCTGTG
TGTGCGTATCCACACTAGGGGTGCAAGCCTCTGGGTGTGTGTGTGTGTGTGCGTGCGTGTGTGTGTGTGTGTCCGTGTGTGTGTGTGTGT
GTGTCCACACTGGCCAGCCTCCCTACTTACCAAGGTTCTCCACTGCTTACCTTTTCCAGTGGGACAGTACAGTGTGAGCCCCCGGGAAGT
ACTGCCTGACCTATCCTAAGCTTTTACACTTGGATTTTAGCCATCATATGTTGGCCAGGTCTCACTGCAGCCTGCCCGAGGCTAACTGGC
TAGAGCCTCCAGGCCCTATGATGCTCCCTGCCCAGGCCATATCCTTTATTCCTGCTGAGCTTCCTGGCTGAATAGATGAAATGGGGTCAA
GCCCAGGCAGCTCATTCACTACCTGTGATCCACCTCAGGGCACGGGCAAACACATAGGCTTGCGTCTTAAAGCCAGCTCCTCTGCCAGAC
CCCGTTGTAATGTGCCACAACACCCTCAATAGTCAGGGCAACTGGTGGAGCATGGAAGTCGAATTTCCTTTTCTGTTAGGAGCTACTCCT
GGGAACCCCTCTCAGGGCTGCAGCTTACAGGTGGGCAGCTGTGATTGCACAACTTGAAGGGCCATCATTCACATCTATTCAGTGGGAGTG
GGGTCCCTGGGATTGGGCAGTGTGGTGGCCCTGTGTCTCCTCACCTCTGCTCCTGTCTTCATCACCTTCTCTCTGGAAGGGAAGAGGAGT
TGGAAGGTCTCTGGTTTTCTTTTCTTTTTTTTTTTTTTTGCCAAAGGTTTACTTCCAGCATCTGAGCTCTGGCTCTCACCCCTGAAGCTC
AGTTATAGTGCACTGATGAACTGAGAGGATGCGTGTGGATGTGTGTGCATGCCTGAGTGCGTTTTTTGGGGAGGGGTGTTTATTTTTAGT
ACCCCATTCTGGGGTTCTCTGATGCAGTGTGGATGTGAAGATATGGTACCTTCTCAAGTGTAGCTCTTTCAAATATAGTCAATGCTGGGA
AATGTGATTGCAGTGATCTCTATCTCTCCACTTCTTTTGGGAAAGAGGAGCACAGGAGCGGAGGAAAAACTTGGCCACAGTCACACTTGG
AAAGATAGTAGATTATTTTCGTTCTCCTCAGCAGGTCTGCTGTATTCCTCGCTCAGCGCTCAAAGATGTGGGTGATGTGTCAAGGAGGCA
TGCACTCAGCTGGTCCTTGCTGAGTTATTTGCTGACACAGGTCTCACTAAGGTGGCTGAGGGGTGGGAGGGAGAAGGCTAATCTTGGAAC
CTTCACAGGATTGGCCTTGATCCTTGGGTAACACAAGAGTGATTCCTGATTTTTAGACACCTAATATGTGCCTAGTGCTTTTCTCTTTGT
TCCTCACTATCCTGCAAGGTAGGTATTCTCACTTACAGATGAATAAATGGGCTCAGAGAGATTAGGTGATTAGTGACAATCAGTTGTAAC
TTAGCACTGTTAGGCTGCAAACCCCTTGCTCCTTCCTTTCCACCAAACTATGTTGATTTTCCTTCCTTACCTCCCTCCTTGTACCACAGG
TTCTGTCCTCAAGATATCACCCCACTGGGCAGTATCTGAAGGCAGACCCAGCCCAAGATGGTGCAGAATATACAGCTCAGGGTGAAAGTT
CTTCTGGGCTCCTGCTAACAAAGTCTTGGAAAAACTGCCTGGGAAGCCATATTATGAATTAGTGCTAGAAGAAGCTGTGGGGGGAACTGA
GTTCTGTGTCTAATTGCATTACTTATGTGTCCTTGAATAGGACCCATAACTCCTCCCGGCATGCTTTTGCATCTATAGAACTGAAGCTGT
AGTTCTAGATGGCACTAAGGGTCTTGGTTCATATTCAGCTGCTGCTTCCCCCCAAGGAAAAGATGAGGTTTTTCCCCTTCGATTACCTTT
TGAGGGATGTTTAGGCTCAAATTCTGCTTGCCACAGAGGAAACATTTCTGCTGTAGTTGTTTACCTCCATCCTAGCTGGCAGTGTGGGAC
ACACACATACAGCAAGTGAAGGTGGGGGTTTGGGCCTGTATAGAGGTCAGCTACGCTGCAGGCTCATCTATTCACACCAGCAGGTACAGA
GAAAACTAGTGTTTTGTAAAGTCAAATATTTGTTGGGGGTTGGAGTTCTGGGGTTGGAGGAGGGGCTGTTCTGGGCATCAGTTGAGCAGA
TGCCCAGGATGCCTGGGGGAGACCAGCTTCCCCTACAAATCAGAGCTCTAAATTACAAGGTTTTTACCAACGTGAACAGTTGGGGGAAGT
CGTCTGCTCTCATTTGCGTAATGGTTTCTGTCACTGGTGATTAGACACAGGATGAAGGAAAAGAAATTTGACAATTAGGAATGAGCGATC
ATTAATCTGAATCTGTTAGGAGACAGAGAGGGGAAGGATCCTTATCAGTGGGCCAGCCCAGTATGGGGAGACACTCCCTCCCTCTGCCCC
CAGAGACTCCTGGGCTACATCCTCTTTCAGTATTGCCACAAGTGGGCAGAGCTTGTATTTCTTAACAAAGATTAGGGACCCAGTTGCCAG
CCTGAGATGGATATAGGAACAGACATCTTTGGGCATGAGCCAACAAAGATAGAAATAGATGAGTGTCAGGTACAAGCTATAAGGCAAAGA
ATAACAGTGGAAAAGTTTTGACATGTGTTTGCCATTTGTGGAAAATGTTTTTGTAATAGTCAACACCCCTCATAGCCCACCTGTGACAAG
TACTTGTTACATTCCAGCACTGTAGGGCGTGAGGAAAATCTGGTCCTTATCAAATCCCAGGAGCTTCTGCTTAGTTGGGGAAGAAATTAC
ATGAAGCAACCAGAGGTTATAAGGCCACACTTGTATATCGTGCACCCTGTGTGGACAAGATTAGGGACTGTTGAGAGAGGAGGAAACCAG
TAGAGAGCAAAGCTCTACCCAGGCTCCTTGTAAGCCTCTGGGCTCCCCCGAGAGGGCCTCGCTACTCTACGCTTCCTAGCAACGTTGATG
TCCCCACAACCCCACATCAGTGCAGCTGTGGCTGTGTGGAGGGGCTCTGAGGCCTCTGAGGCCAGATGTGTAAACAGTGCTGAGGTTCAG
TAATAGGATGAGTCTTCAGGTGTGGAGCAGCCCACCTTGGCTCTTCCCATGTCTCTGTGTTACTTCTCATATTCTGCTGTCCTTTCAAAC
TTCAAGGACAGTATTAATTTATACTAGTATTTCTTCCTCAGTTTTGTGACTTGAATGCAGTGAGTGCCTTAGAGGATCCAAGGATGAAGG
AATGCGGGTTGGTGGTTCTCTCTTTCAGAATGGGAACTTCCCAAAAATGGGGCTGCGTCTCGCCTCTCAGTAGGTTCCCTACCTCTGGGT
CTTCCACCCTTCAAAATCTGGTACAGAATTTAGCAGGGGCTGCAGGGAATGACCCTCAGGGACCAGTTTCACCCAGATGGGGTAGATGAT
GAGGTATACCTAGAAGTAGCTCAGGGCTCCAGAGTCTGGCCTTTCAGCTGGTGTCTTACTCCCCTTTGAGACCTTCAGCTGCTTGTCTTC
CACTGCCTGCATACTTCTCTGATGTCTTCTCAAACTGTTGGCTCTAAAGGGATGTTCCAGCCTCCCTCTCCAGAGCTGCCTGCAGTTTCC
CTTATTCAGCTGTCTCCTGCCTAGTCTCTCCAGCGGCCTCCTTACCAAGACCCTTTTTCCTAAACAGTTGTCCTTCCCTCAGAAACTCCA
TGGCTGCAAGTGTGAATAGACTTGTCTTTAGGATCCCTCTCTCTGGTCATCCCTGATCATCTTAGGGCCGTCTCCCTTTTCTGATTTTTG
ACAGCTCTGTTTATTTTGCCCATGGCTAGTCCTCTTGTTTTGTGTCTGCTGTGTGTTCTTGCCCTTCCATTGTCAGTTCTGTACATCCTG
GTTCAGCTTGTCTCACTGTGGTAGCCCCTTCTGCTTGTCTTCAGCCATCTTGGTTTAATCCTCATAGGTCATGGATGAATGGAGCCTTGC
TGAGCACTTTGAGGGCATTTCTGTTGGGCACAACCTCAGAAACGGGAAGTCTTGAGGCCTGGGGGCGTGTGGTCAGTGAGGCCTCCAGAG
GTGGGTTAGGGGTGGGCACCTACAAGGGCCAGTTGAGGGGAGAGGTGCAGGGATTGCTGAGGAGACTTTGTGAGAATGATGTCAGGCCCG
GGAAGCTGGTGTGGAAGAACTGAGCTGTCAGAAGGAGATACCAATATCCCCTTTGCAGGGTGGTGATGGGCATCAAACATGACGTGGAAC
ATGTCCCCTTCATGGAGGGTTTCCATCTAAATGCATCTGTGTGCCTTAGGGATCAGTAGTTCAGGGGTGGTGGACTTTTTTGAGTGTCTC
CTAATTTCTCTGAGGTGTCTTTGGCTCTGTGTCACCAAATGTGCCTGACCTCTGCATCCCAGTGGTTGCTGAAAGGGAAACAGTATATTG
CGTAGTCAGATGTCAGGAGTAGAGATCTTAATGAGAAAGGCCCTGGCAGCTGGAGAGATGAGAGGACCTAGTGGTCAGCTTATACCCAGA
CTATCTCTCCACTCCTCCAAGAGTTTGAGTCCCATAGCTGATGAAAGAATTTACATATGGGCTCCCCCCTGCTTTCCCACTGAAAATCTA
TTCTCATATTTTGGGAAGGAGCATATGTCCTTTAACTTTCAATGGTAAACAATCTAGGATAGTGTTTAAAGGCATGGATTTTGGAGTCAC
ATATAGTTGGTTTGAATTTCTAGCTTCACTACTTACCAGCTGGGTTTGACCTTGGTTGATTTACTTAACCTCTCTGAGCCTCAGTTTCCT
CAACTATAATAACATGGGTGGAGGGAGGCATGTTGAAAATATCTACCTCAGGGTTGTTGGAATAACTGAAACAATGTTTGTAAAGCTTTA
GCACAGTGCCTGGCAAGCACTTAATAAATGGCTGTGGTGGTGGTGGTTATATTTATTATGTGATTTATTCAGAAACTTGGTTTCAGTGAT
CTCTAAACAGATTTCCAGTGGTTCTTTCTCTCTCAAGAAAAGCATAGGGAAAAACGAGAAACACCTTAGATAAACCATATTGAGTTGAGG
GTAGACAGAAGAGTCTAGTACCTAAACTCACCCTAGAGGAAGAGAAACAGGAAGTGTCTTATGCCTCTTCTGCCTGGGCAGCCAGACTTT
ACTGCTGTACTACCAGCCCAGGGCCTTGGGTGAGAAGGTTTCAGGTCTGAGCTCCCCTTGCACTGTGTGAGAGGCCGTGGAGCCGAATGA
GTCCTTATTATACCTGGAGAAGCTGTTGTCTCCTCACACCATGAAATGTAATAGCAGTCAAATCAGGCCCCTCTTGATTCAATTTTAGTC
CATGCCTTTCCATGTATTTAAATTATATAAGTGTTGGCCAGGTGTGGTGGCTCACACCTGTAATCCCAGCACTTCGGGAGGCTGAGGCAG
GAGGATCACTTGAGCCCAGGAGTTCGAACCAACCTTGGGCAGCATAGTGAGACCCCTTCTCTTAATAATTTTTTTTGAAAATAATTTTTT
AAAAATTACAAATATGGACCAGACACCTGGGAGGATTACCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGTGGATCACCT
GAGGTCAGGAGTTTGAGACTATCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCAGATGTGGTGGTGGGTA
CCTGTAATCCCAGCTACTCGGGAGGCTGAGACAGGAGAATCACTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCTGAGATCACGTCATTG
CACTCCAGCCTGGGTGACTACAGTGAGACTCCCTCTCAAAAAAAAAAAAAAAAAATTATGAGTATGTTAAGATTGTTCTAGGGGAGAAGG
GCAATCAAAATTCAGAAAAATATGAGTGGGATGTTAATAGCTACCATTTGTTGAACACTTCTGTTCCAGGCACTGTATTAGTTCGTCCCC
ATGTGGTGCTCTCAGATCAGTAGGGGAGACAGGCAGGCAGTTAGAATTATGGTGTATAGAGGAGAAGCATTGCACTATGTCCAGTTTTTT
ATGGTAGGCTTCCTGCAGAAAGTGATAAGTCCAAGCTGATATGTGGAAGATGAATAATTAACCAGAGGTTGGGGGATTTCCCCCTTAGCT
TCTCTTTCTTCCAGTCCAGCAGTCCAAAACAAACACTGCTTCCCAATGCCTAAGGGTTTTGTCGTACCTTACTCCAGGGAATGGGTGAGA
CAGTAGATCCCAAGAAGAAAACCCTTTGGTTAGTCACAGAAATCTGAAAGTCTTGGTTGCTGGCTCAGATTTGTCCTGGAGTGGACGTAG
ATTGGACTTGCTTATTTGTAGCCCTCCACCGTTCTCATTTGTGTTCTGGCCTCTGGAGCCACCCTGCCAGACCCTACTTGGAAGAAATGT
TGAATCAAGCTACTCAGACTTCAGCCTGAGATGTATTATGGCTGGCTGGAATTCTCAGCCCTTTCCACATCATGATCCCATTAATCTCTT
GGGTCTATCCCCACGCCCAGCCACCTCTCCTCCTCACTATAAGCCAAGTCTCCCTGCAGTTCTCTATAAATACTCAGATCCTCTTGCCTC
AGACCCTGGTCCCTAGCTTTGTGGGTGAAGAAGATACCTCTTTAGCTTGTGCCAACCCATCCCTCTGGGCTACAGGCCATTCTGTAGTCA
CCTTGCAGTCACGTCTTTCCTTCTAGATAACTGGCTCTGGGCCTTGGAAACCTTCTCTTTGGCTCTAGCTAATTTTGCTGTTTTATTCCG
TTTACTTAAAACCTATTCACTTGGTCATTGAGGTCAGAACTATCAGGAAAGCTGTGCTCCTTAACCCATCATCTAAGCTAAGCTTGGGCC
AGGTTTTTATTACCTCTTGAATATATATAGTGCAATATAGTGTAGTGGTTGAGAGTGGAGTCTGCATACCTGGATCTGCCATTCTGCATG
ACTTTGGGCAAATGGACAAACTGCCCGAAACTTGACTTGTTTATATGTATGGGGAAGACATCATTTACATTGTCAGGGTAAGGCTTAGCA
GAATGACCGGTCCATAGCAAGGGCTCAGTCTTTCTGTGTCTCTCAGTCTTTACCTCTCTTCCCCATCTAGCTTTCTGTCTAAGTTCCTGT
TTCTAGTCTCAGGGCATATCTAGTTGTCAGCTCCTGAGCAGAGCAGAGGTATAAGTGTCAACTCATGCTTGTGTTACCAGTTCCTACCCC
TGTCAGTAACCTCTGATGCTTACAAGGATACTATCACCTATGCCATCAGTGGGGAATGACCTTCCAAAAATATTTTTAACAATACTAAAA
ATACCTGAAACATACTGGGTGAAAATAAGACATTGGAGCTGCTGCTCCCCAAGGAGATAAAAGGACAGTTCCTAAAGAGGCATTGAAGGT
TTGTATGAGCCAGCAGCACAGTCAGAAGGCAAGAAGGAGACCCTGGGATGTGCACAAGGATGCAGGAGACGAGATTGTCACAGAGGCTGT
CATGCTAGTAAGAGTCAGAGGTTACTGATGGGTAGAGATTGTCAGAGTCTGCCTTGCTAGTCTAGAGGTAGGACCATGGATTTAAGAACG
TTGCCTCCAAGTTTTTGAATTGTGAATTTTTGATCATATTTGAACAAAACCCCACCTACAGTCTGCATGGTCATTGTTCTCACAAGGGTT
TGTGTGATGCACTGACAAGAACAGAGGCTTTGGAGGTGACTCCTGGGTTTGAATCACCATTTGCCACTAGCTAATTCTAACCTTAGGTAA
GTCAGTGTCTCTGGGTCTCAACCTCTTCCTCTGTGAGGGGTAGGAAATAGCACATAACTTGTAGCATTGTTATAAGGGCTCGTGATAATG
TTTTTAAAACACCTGGCTCAAGCACTCAGGAAAATGTTTTATTATGAAGACCAAGTGTCTCTGAAAAGTGTTTCCTTAGTGTCTGGAGAG
ACTACAGCAGCAAGGCTTTTCTGATCCTACTCTGACTCTCAAGATAATGGTGCTTGAAGTGAAATCACAGAAGAGATGACTGGGGCAGGA
AAAGCAAGATGGAAAAGATAAAGTTGTGGAAGGGACTGAAAGTCCATGAAGTGCTGGGCTGGGGACAGAAAGGGTTTAATAGGGCAGGGT
CTTGAGGAACAGGAACAGAGACCTTGGTTCTGGGTTGCCATCTGATTCCCAGAAGAGTAAAGGAAATGGGGCAGGAGGATGTCTGTGGAG
GACACAGTGTGGCTGAGTGGAGAGAACACAAGCTTCTGGCCAGTGAACCTAAGTGAGAATGTCAGTGGACTTTGCACAGGCTGGGTGCCT
TTGGGGGTGTTCATCTCGCTATGCTTCGGTCCCCTCATTTAAAAAAATTGGTTAATAATATGATGACCTGCCAATGTGTGTGGAAATACT
ATGTAAACTGAGCACTATATAAATGCTGGTTGTTGAGATATTGGGAGTGGGGGTTTCGGGAGATTTTGTTTGTTTGTTTTTTTGAGATGG
AGTTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTTGGCTCACTGCAACCTCCACCTCCTCCAGGTTCAAGCAATTCTGC
CTCAGCCTCCCGAGTAGCTGGGACTCAGGCGTGCGCCACCATGCCTGGCTAATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTG
GTCAGGCTGGTCTCGAACTCCCGACCTCAGGTGATCTGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGCGAGCTACCACACCT
GGCCCTGGATTTCTTAATAGGTCCTCTTATGTGGCTATTGAGAATGAATGAGACAACTCATTAACTAACTAAGTTAATTCAGAACTTAGT
GCCTAGTAAGTGCTCAGTAAATGTTAGTTTCTTTTCCTCCATTTCTTCTTAGGAAGCATCGTTTACCCAGCATAAACAGGAGGACTCAAC
TGTGCATGTCTTAGTGTGAACAAGTAACATCAGATTTCCCTTTTCTGAGGAGAGATCAGTTCTGTAAGAGGGAGCATGAGTGTGAATGGG
GAAGAATCATGGAGAAGGGAGCAGGACTCCACAGTACTGGAGATGGAGTAGGGACCTCTGGGAATCGTTGGCATGGGGGTGTGGTGCAGA
AAGGGTGATGCTAAGAGGTGAGAGTCTCAAGAAAGAAGATGGGTGTTCTAGAGGGGAAAGCTAAACGATGATAGGCAATGAGGAGCGGAG
GACAAGACCCTGAACTAAGGGTGAGGAGGCCAGCATTCTGTCAGGAGAACCTTAGGAATTGTGACCAGAAGTCAAAGTTGTTACAGCAAT
CCTGCATTCAACCAGGTTTCATCTGAAAAACTTAAGAGTTGCTAGGCACAGTCGTGCACACTTGTAATCCCAACACTTTGGGAGGCTTGA
GTCAGGAGGAAGCTTGAGGCCAGGAGTTTGAGATCAGCCTAGGCAGCATAGTGACACCCCATCTCTTGAAAAAACAAACACTCTTAAGAG
CAGTGGTTCACCTAGAAATAAAAAGCAGAAATCATCAAGATGAGAAGACATTTTGTGTTTTGACAGCCAAGGAAATTTGCCACTGAGACA
AGGTATCTGACAGCCTAGATGGGATTCTAGACTTCTGTGAGAAAGTGCAGTTAGGCCCTGAATAGCGTCAAACTCAGGGATGTGAGCTGA
CTGACTGCCTTTTTATGTAATGGAGGCCATGTGATAGGGCTTTATGAGGCCACAAATAGCACTTTCTGGGTCCTTTCACAGTCTAGTCAG
TGGCCCAACCAACATATCTGGTTGTTCTGCAATCTCAGTCATCTGAGAAGATAACCTCCAAAATACATGCAGTGGCATCAGGTGTTTCCT
TGGTAGGTGTGCATCTTTTAATGATGGAGGACTTAGGATGAAGAACAGGTGTGTTTAAAAACATCAAACCCCCACATCATTACTATTTGC
TGTAAGGATCTATGCAGTTTGTATTTTAAGTCCTTGACATATGGAAGAGCATTTGTGAGAGTAACAGGTTTGCTTTGTAATGCCAACTAA
AAAGTGTGTATTTATACTCGAATTTTAAGTTGAAATTTTGCTAAGTTTCTTTTTTTTTTTTTTGAGACGGAGTCTCACTCTGTTGCCCAG
GCTGGAGTACAGTGGTACAATCATTGCTAAGTCTTTCTGTAGTTTTAGAACATTTAGAACAACTTAAGATTTCCTGTATTTATAAACTTA
ATTTATTGGAAATATAAGTACTTGATCAGGTTTTGTCTTGGTCAGATAAATTAAGTACTTAAGGAAATCAAATACATTAATCATATAAAT
GCCATTTAAGTGTTTAAAGGAGTTTAGTTAAATGTAAGTTGGATCAAACATTAAACTTTTTTGTTTTATAAGCAAAATAATAAGATTTGT
TAGCAGAACTTAAAAGCTTAGAAAAGAGAGGATTTTGGATATGTAACTTTGAAGAGGTGAATAGTTTGCTCTTTTCTGAGACAGGGCATT
GCTTTTCGACGCAGGCTGGAGTGCAGTGGGGCAAGCATGGCTCACTGCAGCCTCAACCTCCTGGACTCAAGTGATCCTCCTGCCTCAGCC
TCCCATGTAGCTGGGATCACAGGCACATGCCACCACACCTGGCTAATTTTTTATTTTTTGTAGAGACAGGGGCCTCACTTCATTGCCCAG
GCGGATCTCGAACACCTGGGCTCAAGCAGTCCTGCCTCAGCCTCCCAAAGTTCTGGGATTACAGGCATAAGCCACTGTGCCTGGCCTTGA
ATATATTTTTTAACCAAAGTAATTTATGAATATAAATTGTTTCTATATAACCCAAAGTCACTCTCATTGACATTAAGAAACTCAGAGAGT
GGGTTCTAAATGTAATATTACCACACACCCAAGTCACTTAGCCTCTACAAGTACCACGTAACTAGCAGCCGTTAAAAGATGGCCACCGCT
AGTCCAGTCGGCCACAGACATGGTTTTGTTTGGCCAATACAAGTTTTTGAAAGTTTTAAAAAATTGACAACATTAAAGATCAGAAACTTG

>10564_10564_2_BTRC-HIF1AN_BTRC_chr10_103190209_ENST00000393441_HIF1AN_chr10_102296168_ENST00000299163_length(amino acids)=360AA_BP=70
MAPKGRPRRRADPVASAIMDPAEAVLQEKALKFMCSMPRSLWLGCSSLADSMPSLRCLYNPGTGALTAFQEPVVLTDTNLVYPALKWDLE
YLQENIGNGDFSVYSASTHKFLYYDEKKMANFQNFKPRSNREEMKFHEFVEKLQDIQQRGGEERLYLQQTLNDTVGRKIVMDFLGFNWNW
INKQQGKRGWGQLTSNLLLIGMEGNVTPAHYDEQQNFFAQIKGYKRCILFPPDQFECLYPYPVHHPCDRQSQVDFDNPDYERFPNFQNVV
GYETVVGPGDVLYIPMYWWHHIESLLNGGITITVNFWYKGAPTPKRIEYPLKAHQKVAIMRNIEKMLGEALGNPQEVGPLLNTMIKGRYN

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Fusion Gene PPI Analysis for BTRC-HIF1AN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneHIF1ANchr10:103190209chr10:102296168ENST00000299163082_12559.0350.0VHL


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BTRC-HIF1AN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BTRC-HIF1AN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBTRCC0265554Ectrodactyly2ORPHANET