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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BAZ1B-MET (FusionGDB2 ID:HG9031TG4233)

Fusion Gene Summary for BAZ1B-MET

check button Fusion gene summary
Fusion gene informationFusion gene name: BAZ1B-MET
Fusion gene ID: hg9031tg4233
HgeneTgene
Gene symbol

BAZ1B

MET

Gene ID

9031

4233

Gene namebromodomain adjacent to zinc finger domain 1BMET proto-oncogene, receptor tyrosine kinase
SynonymsWBSCR10|WBSCR9|WSTFAUTS9|DFNB97|HGFR|RCCP2|c-Met
Cytomap('BAZ1B')('MET')

7q11.23

7q31.2

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein kinase BAZ1BhWALp2transcription factor WSTFwilliams syndrome transcription factorwilliams-Beuren syndrome chromosomal region 10 proteinwilliams-Beuren syndrome chromosomal region 9 proteinhepatocyte growth factor receptorHGF receptorHGF/SF receptorSF receptorproto-oncogene c-Metscatter factor receptortyrosine-protein kinase Met
Modification date2020031320200315
UniProtAcc.

P08581

Ensembl transtripts involved in fusion geneENST00000339594, ENST00000404251, 
Fusion gene scores* DoF score14 X 17 X 6=142814 X 18 X 10=2520
# samples 2027
** MAII scorelog2(20/1428*10)=-2.83592407425437
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/2520*10)=-3.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BAZ1B [Title/Abstract] AND MET [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBAZ1B(72912827)-MET(116435709), # samples:1
Anticipated loss of major functional domain due to fusion event.BAZ1B-MET seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BAZ1B-MET seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BAZ1B-MET seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BAZ1B-MET seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BAZ1B-MET seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
BAZ1B-MET seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
BAZ1B-MET seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
BAZ1B-MET seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
BAZ1B-MET seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
BAZ1B-MET seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
BAZ1B-MET seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBAZ1B

GO:0006974

cellular response to DNA damage stimulus

19092802

HgeneBAZ1B

GO:0016572

histone phosphorylation

19092802

TgeneMET

GO:0001886

endothelial cell morphogenesis

14500721

TgeneMET

GO:0035024

negative regulation of Rho protein signal transduction

25198505

TgeneMET

GO:0045944

positive regulation of transcription by RNA polymerase II

22521434

TgeneMET

GO:0050918

positive chemotaxis

15218527

TgeneMET

GO:0051497

negative regulation of stress fiber assembly

25198505

TgeneMET

GO:0070495

negative regulation of thrombin-activated receptor signaling pathway

25198505

TgeneMET

GO:0071526

semaphorin-plexin signaling pathway

15218527

TgeneMET

GO:1905098

negative regulation of guanyl-nucleotide exchange factor activity

25198505


check buttonFusion gene breakpoints across BAZ1B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MET (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8080-01ABAZ1Bchr7

72912827

-METchr7

116435709

+


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Fusion Gene ORF analysis for BAZ1B-MET

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000339594ENST00000436117BAZ1Bchr7

72912827

-METchr7

116435709

+
5CDS-intronENST00000339594ENST00000495962BAZ1Bchr7

72912827

-METchr7

116435709

+
5CDS-intronENST00000339594ENST00000539704BAZ1Bchr7

72912827

-METchr7

116435709

+
5CDS-intronENST00000404251ENST00000436117BAZ1Bchr7

72912827

-METchr7

116435709

+
5CDS-intronENST00000404251ENST00000495962BAZ1Bchr7

72912827

-METchr7

116435709

+
5CDS-intronENST00000404251ENST00000539704BAZ1Bchr7

72912827

-METchr7

116435709

+
Frame-shiftENST00000404251ENST00000318493BAZ1Bchr7

72912827

-METchr7

116435709

+
Frame-shiftENST00000404251ENST00000397752BAZ1Bchr7

72912827

-METchr7

116435709

+
In-frameENST00000339594ENST00000318493BAZ1Bchr7

72912827

-METchr7

116435709

+
In-frameENST00000339594ENST00000397752BAZ1Bchr7

72912827

-METchr7

116435709

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000339594BAZ1Bchr772912827-ENST00000397752METchr7116435709+3547910168968266
ENST00000339594BAZ1Bchr772912827-ENST00000318493METchr7116435709+1503910168968266

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000339594ENST00000397752BAZ1Bchr772912827-METchr7116435709+0.0005505120.99944943
ENST00000339594ENST00000318493BAZ1Bchr772912827-METchr7116435709+0.0015911220.99840885

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Fusion Genomic Features for BAZ1B-MET


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
BAZ1Bchr772912826-METchr7116435708+5.04E-091
BAZ1Bchr772912826-METchr7116435708+5.04E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for BAZ1B-MET


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:72912827/chr7:116435709)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MET

P08581

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity). {ECO:0000250|UniProtKB:P16056}.; FUNCTION: (Microbial infection) Acts as a receptor for Listeria monocytogenes internalin InlB, mediating entry of the pathogen into cells. {ECO:0000269|PubMed:11081636, ECO:0000305|PubMed:17662939, ECO:0000305|PubMed:19900460}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBAZ1Bchr7:72912827chr7:116435709ENST00000339594-42020_1261901852.6666666666667DomainWAC
HgeneBAZ1Bchr7:72912827chr7:116435709ENST00000404251-41920_1261901484.0DomainWAC
TgeneMETchr7:72912827chr7:116435709ENST00000436117091078_13450765.0DomainProtein kinase
TgeneMETchr7:72912827chr7:116435709ENST000004361170927_5150765.0DomainSema
TgeneMETchr7:72912827chr7:116435709ENST0000043611709563_6550765.0DomainNote=IPT/TIG 1
TgeneMETchr7:72912827chr7:116435709ENST0000043611709657_7390765.0DomainNote=IPT/TIG 2
TgeneMETchr7:72912827chr7:116435709ENST0000043611709742_8360765.0DomainNote=IPT/TIG 3
TgeneMETchr7:72912827chr7:116435709ENST00000436117091084_10920765.0Nucleotide bindingATP
TgeneMETchr7:72912827chr7:116435709ENST000004361170925_9320765.0Topological domainExtracellular
TgeneMETchr7:72912827chr7:116435709ENST0000043611709956_13900765.0Topological domainCytoplasmic
TgeneMETchr7:72912827chr7:116435709ENST0000043611709933_9550765.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBAZ1Bchr7:72912827chr7:116435709ENST00000339594-4201245_12831901852.6666666666667Coiled coilOntology_term=ECO:0000255
HgeneBAZ1Bchr7:72912827chr7:116435709ENST00000339594-420533_5861901852.6666666666667Coiled coilOntology_term=ECO:0000255
HgeneBAZ1Bchr7:72912827chr7:116435709ENST00000339594-420768_8141901852.6666666666667Coiled coilOntology_term=ECO:0000255
HgeneBAZ1Bchr7:72912827chr7:116435709ENST00000339594-420850_8931901852.6666666666667Coiled coilOntology_term=ECO:0000255
HgeneBAZ1Bchr7:72912827chr7:116435709ENST00000404251-4191245_12831901484.0Coiled coilOntology_term=ECO:0000255
HgeneBAZ1Bchr7:72912827chr7:116435709ENST00000404251-419533_5861901484.0Coiled coilOntology_term=ECO:0000255
HgeneBAZ1Bchr7:72912827chr7:116435709ENST00000404251-419768_8141901484.0Coiled coilOntology_term=ECO:0000255
HgeneBAZ1Bchr7:72912827chr7:116435709ENST00000404251-419850_8931901484.0Coiled coilOntology_term=ECO:0000255
HgeneBAZ1Bchr7:72912827chr7:116435709ENST00000339594-4201261_12731901852.6666666666667Compositional biasNote=Poly-Glu
HgeneBAZ1Bchr7:72912827chr7:116435709ENST00000339594-420306_5781901852.6666666666667Compositional biasNote=Lys-rich
HgeneBAZ1Bchr7:72912827chr7:116435709ENST00000404251-4191261_12731901484.0Compositional biasNote=Poly-Glu
HgeneBAZ1Bchr7:72912827chr7:116435709ENST00000404251-419306_5781901484.0Compositional biasNote=Lys-rich
HgeneBAZ1Bchr7:72912827chr7:116435709ENST00000339594-4201356_14261901852.6666666666667DomainBromo
HgeneBAZ1Bchr7:72912827chr7:116435709ENST00000339594-420604_6681901852.6666666666667DomainDDT
HgeneBAZ1Bchr7:72912827chr7:116435709ENST00000404251-4191356_14261901484.0DomainBromo
HgeneBAZ1Bchr7:72912827chr7:116435709ENST00000404251-419604_6681901484.0DomainDDT
HgeneBAZ1Bchr7:72912827chr7:116435709ENST00000339594-420207_2131901852.6666666666667MotifNote=C motif
HgeneBAZ1Bchr7:72912827chr7:116435709ENST00000404251-419207_2131901484.0MotifNote=C motif
HgeneBAZ1Bchr7:72912827chr7:116435709ENST00000339594-4201184_12341901852.6666666666667Zinc fingerPHD-type
HgeneBAZ1Bchr7:72912827chr7:116435709ENST00000404251-4191184_12341901484.0Zinc fingerPHD-type
TgeneMETchr7:72912827chr7:116435709ENST0000031849318211078_134512841409.0DomainProtein kinase
TgeneMETchr7:72912827chr7:116435709ENST00000318493182127_51512841409.0DomainSema
TgeneMETchr7:72912827chr7:116435709ENST000003184931821563_65512841409.0DomainNote=IPT/TIG 1
TgeneMETchr7:72912827chr7:116435709ENST000003184931821657_73912841409.0DomainNote=IPT/TIG 2
TgeneMETchr7:72912827chr7:116435709ENST000003184931821742_83612841409.0DomainNote=IPT/TIG 3
TgeneMETchr7:72912827chr7:116435709ENST0000039775218211078_134512661391.0DomainProtein kinase
TgeneMETchr7:72912827chr7:116435709ENST00000397752182127_51512661391.0DomainSema
TgeneMETchr7:72912827chr7:116435709ENST000003977521821563_65512661391.0DomainNote=IPT/TIG 1
TgeneMETchr7:72912827chr7:116435709ENST000003977521821657_73912661391.0DomainNote=IPT/TIG 2
TgeneMETchr7:72912827chr7:116435709ENST000003977521821742_83612661391.0DomainNote=IPT/TIG 3
TgeneMETchr7:72912827chr7:116435709ENST0000031849318211084_109212841409.0Nucleotide bindingATP
TgeneMETchr7:72912827chr7:116435709ENST0000039775218211084_109212661391.0Nucleotide bindingATP
TgeneMETchr7:72912827chr7:116435709ENST00000318493182125_93212841409.0Topological domainExtracellular
TgeneMETchr7:72912827chr7:116435709ENST000003184931821956_139012841409.0Topological domainCytoplasmic
TgeneMETchr7:72912827chr7:116435709ENST00000397752182125_93212661391.0Topological domainExtracellular
TgeneMETchr7:72912827chr7:116435709ENST000003977521821956_139012661391.0Topological domainCytoplasmic
TgeneMETchr7:72912827chr7:116435709ENST000003184931821933_95512841409.0TransmembraneHelical
TgeneMETchr7:72912827chr7:116435709ENST000003977521821933_95512661391.0TransmembraneHelical


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Fusion Gene Sequence for BAZ1B-MET


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>9028_9028_1_BAZ1B-MET_BAZ1B_chr7_72912827_ENST00000339594_MET_chr7_116435709_ENST00000318493_length(transcript)=1503nt_BP=910nt
CGGGGGAGGAGGGGAATCTCCCGCCATTTTTCAATAATTTCCTCCGGTGCTGCTGAGGAGGAGTCGTGACTGCCGGCCGCCGGGACCCGA
AGCGGAGGTCGGCGGGGGGCTGCTGGGAGGCGCGGCGGTGTGCGCGGGAGCTCTGCGCCGTGGCGTTCCGCTCCATGACTGTCGCGCGGC
CGCGCCGGCGGTGAGGGAGCCGGAGTTCGCGCCGCCCTCTCACCCCTCCCTTCCCCCACCCCACCCCCGGGCGCCTGGCGCTCGCTCCGG
GCCGCGGGGCCTAGTGCTGCGCCGCGGGGCCGGCCCCAGCAGCCGCCAGTCCCCACCGCCGCCGCCGCGATGGCGCCGCTCCTGGGCCGC
AAGCCCTTCCCGCTGGTGAAGCCGTTGCCCGGAGAGGAGCCGCTCTTCACCATCCCGCACACTCAGGAGGCCTTCCGCACCCGGGAAGAG
TATGAAGCCCGCTTGGAAAGGTACAGTGAGCGCATTTGGACGTGCAAGAGTACTGGAAGCAGTCAGCTAACACACAAGGAAGCCTGGGAG
GAAGAACAGGAAGTTGCTGAGCTTTTGAAGGAGGAGTTTCCTGCCTGGTATGAGAAGCTTGTTCTGGAAATGGTTCACCATAACACAGCC
TCCTTAGAGAAGTTAGTAGATACTGCTTGGTTGGAGATCATGACCAAATATGCTGTGGGAGAAGAGTGTGACTTCGAGGTTGGGAAGGAG
AAAATGCTCAAGGTGAAGATTGTGAAGATTCATCCTTTGGAGAAAGTGGATGAAGAGGCCACTGAGAAGAAATCTGATGGTGCCTGTGAT
TCTCCATCAAGTGACAAAGAGAACTCCAGTCAGATTGCTCAGGACCATCAGAAGAAGGAGACAGTTGTGAAAGAGGATGAAGGAAGGAGA
GAGAGTATTATGGTCCTTTGGCGTGCTCCTCTGGGAGCTGATGACAAGAGGAGCCCCACCTTATCCTGACGTAAACACCTTTGATATAAC
TGTTTACTTGTTGCAAGGGAGAAGACTCCTACAACCCGAATACTGCCCAGACCCCTTATATGAAGTAATGCTAAAATGCTGGCACCCTAA
AGCCGAAATGCGCCCATCCTTTTCTGAACTGGTGTCCCGGATATCAGCGATCTTCTCTACTTTCATTGGGGAGCACTATGTCCATGTGAA
CGCTACTTATGTGAACGTAAAATGTGTCGCTCCGTATCCTTCTCTGTTGTCATCAGAAGATAACGCTGATGATGAGGTGGACACACGACC
AGCCTCCTTCTGGGAGACATCATAGTGCTAGTACTATGTCAAAGCAACAGTCCACACTTTGTCCAATGGTTTTTTCACTGCCTGACCTTT
AAAAGGCCATCGATATTCTTTGCTCTTGCCAAAATTGCACTATTATAGGACTTGTATTGTTATTTAAATTACTGGATTCTAAGGAATTTC

>9028_9028_1_BAZ1B-MET_BAZ1B_chr7_72912827_ENST00000339594_MET_chr7_116435709_ENST00000318493_length(amino acids)=266AA_BP=248
MSRGRAGGEGAGVRAALSPLPSPTPPPGAWRSLRAAGPSAAPRGRPQQPPVPTAAAAMAPLLGRKPFPLVKPLPGEEPLFTIPHTQEAFR
TREEYEARLERYSERIWTCKSTGSSQLTHKEAWEEEQEVAELLKEEFPAWYEKLVLEMVHHNTASLEKLVDTAWLEIMTKYAVGEECDFE

--------------------------------------------------------------
>9028_9028_2_BAZ1B-MET_BAZ1B_chr7_72912827_ENST00000339594_MET_chr7_116435709_ENST00000397752_length(transcript)=3547nt_BP=910nt
CGGGGGAGGAGGGGAATCTCCCGCCATTTTTCAATAATTTCCTCCGGTGCTGCTGAGGAGGAGTCGTGACTGCCGGCCGCCGGGACCCGA
AGCGGAGGTCGGCGGGGGGCTGCTGGGAGGCGCGGCGGTGTGCGCGGGAGCTCTGCGCCGTGGCGTTCCGCTCCATGACTGTCGCGCGGC
CGCGCCGGCGGTGAGGGAGCCGGAGTTCGCGCCGCCCTCTCACCCCTCCCTTCCCCCACCCCACCCCCGGGCGCCTGGCGCTCGCTCCGG
GCCGCGGGGCCTAGTGCTGCGCCGCGGGGCCGGCCCCAGCAGCCGCCAGTCCCCACCGCCGCCGCCGCGATGGCGCCGCTCCTGGGCCGC
AAGCCCTTCCCGCTGGTGAAGCCGTTGCCCGGAGAGGAGCCGCTCTTCACCATCCCGCACACTCAGGAGGCCTTCCGCACCCGGGAAGAG
TATGAAGCCCGCTTGGAAAGGTACAGTGAGCGCATTTGGACGTGCAAGAGTACTGGAAGCAGTCAGCTAACACACAAGGAAGCCTGGGAG
GAAGAACAGGAAGTTGCTGAGCTTTTGAAGGAGGAGTTTCCTGCCTGGTATGAGAAGCTTGTTCTGGAAATGGTTCACCATAACACAGCC
TCCTTAGAGAAGTTAGTAGATACTGCTTGGTTGGAGATCATGACCAAATATGCTGTGGGAGAAGAGTGTGACTTCGAGGTTGGGAAGGAG
AAAATGCTCAAGGTGAAGATTGTGAAGATTCATCCTTTGGAGAAAGTGGATGAAGAGGCCACTGAGAAGAAATCTGATGGTGCCTGTGAT
TCTCCATCAAGTGACAAAGAGAACTCCAGTCAGATTGCTCAGGACCATCAGAAGAAGGAGACAGTTGTGAAAGAGGATGAAGGAAGGAGA
GAGAGTATTATGGTCCTTTGGCGTGCTCCTCTGGGAGCTGATGACAAGAGGAGCCCCACCTTATCCTGACGTAAACACCTTTGATATAAC
TGTTTACTTGTTGCAAGGGAGAAGACTCCTACAACCCGAATACTGCCCAGACCCCTTATATGAAGTAATGCTAAAATGCTGGCACCCTAA
AGCCGAAATGCGCCCATCCTTTTCTGAACTGGTGTCCCGGATATCAGCGATCTTCTCTACTTTCATTGGGGAGCACTATGTCCATGTGAA
CGCTACTTATGTGAACGTAAAATGTGTCGCTCCGTATCCTTCTCTGTTGTCATCAGAAGATAACGCTGATGATGAGGTGGACACACGACC
AGCCTCCTTCTGGGAGACATCATAGTGCTAGTACTATGTCAAAGCAACAGTCCACACTTTGTCCAATGGTTTTTTCACTGCCTGACCTTT
AAAAGGCCATCGATATTCTTTGCTCTTGCCAAAATTGCACTATTATAGGACTTGTATTGTTATTTAAATTACTGGATTCTAAGGAATTTC
TTATCTGACAGAGCATCAGAACCAGAGGCTTGGTCCCACAGGCCACGGACCAATGGCCTGCAGCCGTGACAACACTCCTGTCATATTGGA
GTCCAAAACTTGAATTCTGGGTTGAATTTTTTAAAAATCAGGTACCACTTGATTTCATATGGGAAATTGAAGCAGGAAATATTGAGGGCT
TCTTGATCACAGAAAACTCAGAAGAGATAGTAATGCTCAGGACAGGAGCGGCAGCCCCAGAACAGGCCACTCATTTAGAATTCTAGTGTT
TCAAAACACTTTTGTGTGTTGTATGGTCAATAACATTTTTCATTACTGATGGTGTCATTCACCCATTAGGTAAACATTCCCTTTTAAATG
TTTGTTTGTTTTTTGAGACAGGATCTCACTCTGTTGCCAGGGCTGTAGTGCAGTGGTGTGATCATAGCTCACTGCAACCTCCACCTCCCA
GGCTCAAGCCTCCCGAATAGCTGGGACTACAGGCGCACACCACCATCCCCGGCTAATTTTTGTATTTTTTGTAGAGACGGGGTTTTGCCA
TGTTGCCAAGGCTGGTTTCAAACTCCTGGACTCAAGAAATCCACCCACCTCAGCCTCCCAAAGTGCTAGGATTACAGGCATGAGCCACTG
CGCCCAGCCCTTATAAATTTTTGTATAGACATTCCTTTGGTTGGAAGAATATTTATAGGCAATACAGTCAAAGTTTCAAAATAGCATCAC
ACAAAACATGTTTATAAATGAACAGGATGTAATGTACATAGATGACATTAAGAAAATTTGTATGAAATAATTTAGTCATCATGAAATATT
TAGTTGTCATATAAAAACCCACTGTTTGAGAATGATGCTACTCTGATCTAATGAATGTGAACATGTAGATGTTTTGTGTGTATTTTTTTA
AATGAAAACTCAAAATAAGACAAGTAATTTGTTGATAAATATTTTTAAAGATAACTCAGCATGTTTGTAAAGCAGGATACATTTTACTAA
AAGGTTCATTGGTTCCAATCACAGCTCATAGGTAGAGCAAAGAAAGGGTGGATGGATTGAAAAGATTAGCCTCTGTCTCGGTGGCAGGTT
CCCACCTCGCAAGCAATTGGAAACAAAACTTTTGGGGAGTTTTATTTTGCATTAGGGTGTGTTTTATGTTAAGCAAAACATACTTTAGAA
ACAAATGAAAAAGGCAATTGAAAATCCCAGCTATTTCACCTAGATGGAATAGCCACCCTGAGCAGAACTTTGTGATGCTTCATTCTGTGG
AATTTTGTGCTTGCTACTGTATAGTGCATGTGGTGTAGGTTACTCTAACTGGTTTTGTCGACGTAAACATTTAAAGTGTTATATTTTTTA
TAAAAATGTTTATTTTTAATGATATGAGAAAAATTTTGTTAGGCCACAAAAACACTGCACTGTGAACATTTTAGAAAAGGTATGTCAGAC
TGGGATTAATGACAGCATGATTTTCAATGACTGTAAATTGCGATAAGGAAATGTACTGATTGCCAATACACCCCACCCTCATTACATCAT
CAGGACTTGAAGCCAAGGGTTAACCCAGCAAGCTACAAAGAGGGTGTGTCACACTGAAACTCAATAGTTGAGTTTGGCTGTTGTTGCAGG
AAAATGATTATAACTAAAAGCTCTCTGATAGTGCAGAGACTTACCAGAAGACACAAGGAATTGTACTGAAGAGCTATTACAATCCAAATA
TTGCCGTTTCATAAATGTAATAAGTAATACTAATTCACAGAGTATTGTAAATGGTGGATGACAAAAGAAAATCTGCTCTGTGGAAAGAAA
GAACTGTCTCTACCAGGGTCAAGAGCATGAACGCATCAATAGAAAGAACTCGGGGAAACATCCCATCAACAGGACTACACACTTGTATAT
ACATTCTTGAGAACACTGCAATGTGAAAATCACGTTTGCTATTTATAAACTTGTCCTTAGATTAATGTGTCTGGACAGATTGTGGGAGTA
AGTGATTCTTCTAAGAATTAGATACTTGTCACTGCCTATACCTGCAGCTGAACTGAATGGTACTTCGTATGTTAATAGTTGTTCTGATAA

>9028_9028_2_BAZ1B-MET_BAZ1B_chr7_72912827_ENST00000339594_MET_chr7_116435709_ENST00000397752_length(amino acids)=266AA_BP=248
MSRGRAGGEGAGVRAALSPLPSPTPPPGAWRSLRAAGPSAAPRGRPQQPPVPTAAAAMAPLLGRKPFPLVKPLPGEEPLFTIPHTQEAFR
TREEYEARLERYSERIWTCKSTGSSQLTHKEAWEEEQEVAELLKEEFPAWYEKLVLEMVHHNTASLEKLVDTAWLEIMTKYAVGEECDFE

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Fusion Gene PPI Analysis for BAZ1B-MET


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneMETchr7:72912827chr7:116435709ENST0000031849318211320_13591284.01409.0MUC20
TgeneMETchr7:72912827chr7:116435709ENST0000039775218211320_13591266.01391.0MUC20
TgeneMETchr7:72912827chr7:116435709ENST00000436117091320_13590.0765.0MUC20
TgeneMETchr7:72912827chr7:116435709ENST00000436117091212_13900.0765.0RANBP9


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneMETchr7:72912827chr7:116435709ENST0000031849318211212_13901284.01409.0RANBP9
TgeneMETchr7:72912827chr7:116435709ENST0000039775218211212_13901266.01391.0RANBP9


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BAZ1B-MET


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMETP08581DB08865CrizotinibInhibitorSmall moleculeApproved
TgeneMETP08581DB08875CabozantinibAntagonistSmall moleculeApproved|Investigational
TgeneMETP08581DB11791CapmatinibInhibitorSmall moleculeApproved|Investigational
TgeneMETP08581DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
TgeneMETP08581DB12267BrigatinibInhibitorSmall moleculeApproved|Investigational

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Related Diseases for BAZ1B-MET


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBAZ1BC0175702Williams Syndrome1CTD_human
TgeneC1306837Papillary Renal Cell Carcinoma9CGI;CLINGEN;CTD_human;ORPHANET
TgeneC1336078Papillary renal cell carcinoma, sporadic7CLINGEN
TgeneC1336839Type 1 Papillary Renal Cell Carcinoma5UNIPROT
TgeneC0007131Non-Small Cell Lung Carcinoma4CGI;CTD_human
TgeneC1836723Tibia, Bowing of, with Pseudarthrosis and Pectus Excavatum4ORPHANET
TgeneC4085248OSTEOFIBROUS DYSPLASIA, SUSCEPTIBILITY TO4ORPHANET
TgeneC0001418Adenocarcinoma2CTD_human
TgeneC0004352Autistic Disorder2CTD_human
TgeneC0024623Malignant neoplasm of stomach2CGI;CTD_human;UNIPROT
TgeneC0027627Neoplasm Metastasis2CTD_human
TgeneC0038356Stomach Neoplasms2CGI;CTD_human
TgeneC0205641Adenocarcinoma, Basal Cell2CTD_human
TgeneC0205642Adenocarcinoma, Oxyphilic2CTD_human
TgeneC0205643Carcinoma, Cribriform2CTD_human
TgeneC0205644Carcinoma, Granular Cell2CTD_human
TgeneC0205645Adenocarcinoma, Tubular2CTD_human
TgeneC1708349Hereditary Diffuse Gastric Cancer2CTD_human
TgeneC0004114Astrocytoma1CTD_human
TgeneC0007097Carcinoma1CTD_human
TgeneC0007134Renal Cell Carcinoma1CTD_human
TgeneC0007137Squamous cell carcinoma1CTD_human
TgeneC0009241Cognition Disorders1CTD_human
TgeneC0014859Esophageal Neoplasms1CTD_human
TgeneC0017636Glioblastoma1CTD_human
TgeneC0019189Hepatitis, Chronic1CTD_human
TgeneC0019207Hepatoma, Morris1CTD_human
TgeneC0019208Hepatoma, Novikoff1CTD_human
TgeneC0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneC0023904Liver Neoplasms, Experimental1CTD_human
TgeneC0024121Lung Neoplasms1CTD_human
TgeneC0024232Lymphatic Metastasis1CTD_human
TgeneC0025202melanoma1CTD_human
TgeneC0026998Acute Myeloid Leukemia, M11CTD_human
TgeneC0027626Neoplasm Invasiveness1CTD_human
TgeneC0027819Neuroblastoma1CTD_human
TgeneC0029463Osteosarcoma1CTD_human
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0036341Schizophrenia1CTD_human
TgeneC0037199Sinusitis1CTD_human
TgeneC0086404Experimental Hepatoma1CTD_human
TgeneC0149519Chronic Persistent Hepatitis1CTD_human
TgeneC0205696Anaplastic carcinoma1CTD_human
TgeneC0205697Carcinoma, Spindle-Cell1CTD_human
TgeneC0205698Undifferentiated carcinoma1CTD_human
TgeneC0205699Carcinomatosis1CTD_human
TgeneC0205768Subependymal Giant Cell Astrocytoma1CTD_human
TgeneC0242379Malignant neoplasm of lung1CTD_human
TgeneC0279606Childhood Hepatocellular Carcinoma1ORPHANET
TgeneC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CGI;CTD_human
TgeneC0280783Juvenile Pilocytic Astrocytoma1CTD_human
TgeneC0280785Diffuse Astrocytoma1CTD_human
TgeneC0334579Anaplastic astrocytoma1CTD_human
TgeneC0334580Protoplasmic astrocytoma1CTD_human
TgeneC0334581Gemistocytic astrocytoma1CTD_human
TgeneC0334582Fibrillary Astrocytoma1CTD_human
TgeneC0334583Pilocytic Astrocytoma1CTD_human
TgeneC0334588Giant Cell Glioblastoma1CTD_human
TgeneC0338070Childhood Cerebral Astrocytoma1CTD_human
TgeneC0345967Malignant mesothelioma1CTD_human
TgeneC0376358Malignant neoplasm of prostate1CTD_human
TgeneC0520463Chronic active hepatitis1CTD_human
TgeneC0524611Cryptogenic Chronic Hepatitis1CTD_human
TgeneC0546837Malignant neoplasm of esophagus1CTD_human
TgeneC0547065Mixed oligoastrocytoma1CTD_human
TgeneC0750935Cerebral Astrocytoma1CTD_human
TgeneC0750936Intracranial Astrocytoma1CTD_human
TgeneC0919267ovarian neoplasm1CTD_human
TgeneC1140680Malignant neoplasm of ovary1CTD_human
TgeneC1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneC1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneC1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneC1621958Glioblastoma Multiforme1CTD_human
TgeneC1704230Grade I Astrocytoma1CTD_human
TgeneC1708353Hereditary Paraganglioma-Pheochromocytoma Syndrome1CLINGEN
TgeneC1876165Copper-Overload Cirrhosis1CTD_human
TgeneC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
TgeneC2239176Liver carcinoma1CGI;CTD_human;UNIPROT
TgeneC3711374Nonsyndromic Deafness1CLINGEN
TgeneC4084709DEAFNESS, AUTOSOMAL RECESSIVE 971CTD_human;UNIPROT