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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BTAF1-HECTD2 (FusionGDB2 ID:HG9044TG143279)

Fusion Gene Summary for BTAF1-HECTD2

check button Fusion gene summary
Fusion gene informationFusion gene name: BTAF1-HECTD2
Fusion gene ID: hg9044tg143279
HgeneTgene
Gene symbol

BTAF1

HECTD2

Gene ID

9044

143279

Gene nameB-TFIID TATA-box binding protein associated factor 1HECT domain E3 ubiquitin protein ligase 2
SynonymsMOT1|TAF(II)170|TAF172|TAFII170-
Cytomap('BTAF1')('HECTD2')

10q23.32

10q23.32

Type of geneprotein-codingprotein-coding
DescriptionTATA-binding protein-associated factor 172ATP-dependent helicase BTAF1B-TFIID transcription factor-associated 170 kDa subunitBTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae)Mot1 homologTBP-associaprobable E3 ubiquitin-protein ligase HECTD2HECT domain containing E3 ubiquitin protein ligase 2HECT domain-containing protein 2HECT-type E3 ubiquitin transferase HECTD2
Modification date2020031320200313
UniProtAcc.

Q5U5R9

Ensembl transtripts involved in fusion geneENST00000265990, ENST00000471217, 
ENST00000544642, 
Fusion gene scores* DoF score7 X 4 X 9=2525 X 6 X 6=180
# samples 107
** MAII scorelog2(10/252*10)=-1.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BTAF1 [Title/Abstract] AND HECTD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBTAF1(93695537)-HECTD2(93220183), # samples:1
BTAF1(93683847)-HECTD2(93240851), # samples:1
Anticipated loss of major functional domain due to fusion event.BTAF1-HECTD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BTAF1-HECTD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BTAF1-HECTD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BTAF1-HECTD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BTAF1-HECTD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
BTAF1-HECTD2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBTAF1

GO:0045892

negative regulation of transcription, DNA-templated

9488487


check buttonFusion gene breakpoints across BTAF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across HECTD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-28-5215-01ABTAF1chr10

93683847

+HECTD2chr10

93240851

+
ChimerDB4STADTCGA-VQ-A92DBTAF1chr10

93695537

+HECTD2chr10

93220183

+


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Fusion Gene ORF analysis for BTAF1-HECTD2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000265990ENST00000536715BTAF1chr10

93683847

+HECTD2chr10

93240851

+
5CDS-intronENST00000265990ENST00000298068BTAF1chr10

93683847

+HECTD2chr10

93240851

+
5CDS-intronENST00000265990ENST00000371667BTAF1chr10

93683847

+HECTD2chr10

93240851

+
5CDS-intronENST00000265990ENST00000371667BTAF1chr10

93695537

+HECTD2chr10

93220183

+
5CDS-intronENST00000265990ENST00000371681BTAF1chr10

93683847

+HECTD2chr10

93240851

+
5CDS-intronENST00000265990ENST00000498446BTAF1chr10

93683847

+HECTD2chr10

93240851

+
5CDS-intronENST00000265990ENST00000498446BTAF1chr10

93695537

+HECTD2chr10

93220183

+
5CDS-intronENST00000265990ENST00000536715BTAF1chr10

93695537

+HECTD2chr10

93220183

+
Frame-shiftENST00000265990ENST00000298068BTAF1chr10

93695537

+HECTD2chr10

93220183

+
Frame-shiftENST00000265990ENST00000371681BTAF1chr10

93695537

+HECTD2chr10

93220183

+
Frame-shiftENST00000265990ENST00000446394BTAF1chr10

93695537

+HECTD2chr10

93220183

+
In-frameENST00000265990ENST00000446394BTAF1chr10

93683847

+HECTD2chr10

93240851

+
intron-3CDSENST00000471217ENST00000298068BTAF1chr10

93695537

+HECTD2chr10

93220183

+
intron-3CDSENST00000471217ENST00000371681BTAF1chr10

93695537

+HECTD2chr10

93220183

+
intron-3CDSENST00000471217ENST00000446394BTAF1chr10

93683847

+HECTD2chr10

93240851

+
intron-3CDSENST00000471217ENST00000446394BTAF1chr10

93695537

+HECTD2chr10

93220183

+
intron-3CDSENST00000544642ENST00000298068BTAF1chr10

93695537

+HECTD2chr10

93220183

+
intron-3CDSENST00000544642ENST00000371681BTAF1chr10

93695537

+HECTD2chr10

93220183

+
intron-3CDSENST00000544642ENST00000446394BTAF1chr10

93683847

+HECTD2chr10

93240851

+
intron-3CDSENST00000544642ENST00000446394BTAF1chr10

93695537

+HECTD2chr10

93220183

+
intron-5UTRENST00000471217ENST00000536715BTAF1chr10

93683847

+HECTD2chr10

93240851

+
intron-5UTRENST00000544642ENST00000536715BTAF1chr10

93683847

+HECTD2chr10

93240851

+
intron-intronENST00000471217ENST00000298068BTAF1chr10

93683847

+HECTD2chr10

93240851

+
intron-intronENST00000471217ENST00000371667BTAF1chr10

93683847

+HECTD2chr10

93240851

+
intron-intronENST00000471217ENST00000371667BTAF1chr10

93695537

+HECTD2chr10

93220183

+
intron-intronENST00000471217ENST00000371681BTAF1chr10

93683847

+HECTD2chr10

93240851

+
intron-intronENST00000471217ENST00000498446BTAF1chr10

93683847

+HECTD2chr10

93240851

+
intron-intronENST00000471217ENST00000498446BTAF1chr10

93695537

+HECTD2chr10

93220183

+
intron-intronENST00000471217ENST00000536715BTAF1chr10

93695537

+HECTD2chr10

93220183

+
intron-intronENST00000544642ENST00000298068BTAF1chr10

93683847

+HECTD2chr10

93240851

+
intron-intronENST00000544642ENST00000371667BTAF1chr10

93683847

+HECTD2chr10

93240851

+
intron-intronENST00000544642ENST00000371667BTAF1chr10

93695537

+HECTD2chr10

93220183

+
intron-intronENST00000544642ENST00000371681BTAF1chr10

93683847

+HECTD2chr10

93240851

+
intron-intronENST00000544642ENST00000498446BTAF1chr10

93683847

+HECTD2chr10

93240851

+
intron-intronENST00000544642ENST00000498446BTAF1chr10

93695537

+HECTD2chr10

93220183

+
intron-intronENST00000544642ENST00000536715BTAF1chr10

93695537

+HECTD2chr10

93220183

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265990BTAF1chr1093683847+ENST00000446394HECTD2chr1093240851+43773223081999563

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265990ENST00000446394BTAF1chr1093683847+HECTD2chr1093240851+0.0002428910.9997571

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Fusion Genomic Features for BTAF1-HECTD2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
BTAF1chr1093683847+HECTD2chr1093240850+1.81E-050.9999819
BTAF1chr1093695537+HECTD2chr1093220183+4.88E-070.9999995
BTAF1chr1093683847+HECTD2chr1093240850+1.81E-050.9999819
BTAF1chr1093695537+HECTD2chr1093220183+4.88E-070.9999995

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for BTAF1-HECTD2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:93695537/chr10:93220183)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HECTD2

Q5U5R9

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:28584101}.; FUNCTION: (Microbial infection) Catalyzes ubiquitination of Botulinum neurotoxin A light chain (LC) of C.botulinum neurotoxin type A (BoNT/A). {ECO:0000269|PubMed:28584101}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHECTD2chr10:93683847chr10:93240851ENST00000298068521437_776221777.0DomainHECT
TgeneHECTD2chr10:93683847chr10:93240851ENST0000037168105437_7760208.0DomainHECT

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBTAF1chr10:93683847chr10:93240851ENST00000265990+1381278_145341850.0DomainHelicase ATP-binding
HgeneBTAF1chr10:93683847chr10:93240851ENST00000265990+1381636_179041850.0DomainHelicase C-terminal
HgeneBTAF1chr10:93683847chr10:93240851ENST00000265990+1381404_140741850.0MotifNote=DEGH box
HgeneBTAF1chr10:93683847chr10:93240851ENST00000265990+138191_20741850.0MotifNuclear localization signal
HgeneBTAF1chr10:93683847chr10:93240851ENST00000265990+1381291_129841850.0Nucleotide bindingATP
HgeneBTAF1chr10:93683847chr10:93240851ENST00000265990+1381102_113941850.0RepeatNote=HEAT 7
HgeneBTAF1chr10:93683847chr10:93240851ENST00000265990+1381182_121941850.0RepeatNote=HEAT 8
HgeneBTAF1chr10:93683847chr10:93240851ENST00000265990+138385_42241850.0RepeatNote=HEAT 1
HgeneBTAF1chr10:93683847chr10:93240851ENST00000265990+138426_46341850.0RepeatNote=HEAT 2
HgeneBTAF1chr10:93683847chr10:93240851ENST00000265990+138513_55041850.0RepeatNote=HEAT 3
HgeneBTAF1chr10:93683847chr10:93240851ENST00000265990+138554_59641850.0RepeatNote=HEAT 4
HgeneBTAF1chr10:93683847chr10:93240851ENST00000265990+138818_85541850.0RepeatNote=HEAT 5
HgeneBTAF1chr10:93683847chr10:93240851ENST00000265990+138872_91041850.0RepeatNote=HEAT 6


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Fusion Gene Sequence for BTAF1-HECTD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10422_10422_1_BTAF1-HECTD2_BTAF1_chr10_93683847_ENST00000265990_HECTD2_chr10_93240851_ENST00000446394_length(transcript)=4377nt_BP=322nt
CAGTTGTGCGTGCCGACGCCCGCGTCAGCAAAGAGCGGAGCTGAGGGTACCCGGTTTGAAGTCGTGCGGGTCGGAGGACTGCCGCCTCCG
CTACCGTCTTGGACCCCTGCTTACCGGCCGCCGCGGGGACGAGCTCGGGTAGGCGGCAGGGCAGATGCCCGAGGGCCTGCGCTGGAACGC
CCCACGCCGCACCGGCCGCTCCCCTGTGCTCCGCGGCCTGGGCCTGCGCCGCTCAGCTCTCTGGAAACTAGCGCCTCAGCTGCGCGGCGC
GTAGGTCGCGGGGAGCTCCGAACCGCCGGCGCCCGGCCATGGCGGTCTCCAGTCCACGAACAAAAGATGATCTTAGAGCATATTTTATAC
TTTTACAGAATCCTCAGTTTAATAACACATCTACGTATGTCATCTATGCTCACTTGCTACGACAGATAGCTACCTTAGTGGAAGCTGACC
ATCATTTCCTAGTTCACTGGTTTAAAAAACAGTATTCAAGATTGTCCCAGAAGAGGTTCAAACAATTGGTAGAGAGATTGCTGCAATTTA
TTTCTTTACGCCTGTTTCCTGCAAAGCCTGAAGAATTTCCACCTATAACAAAGTGTTCCTGGTGGATTCCATCAGCCGCTAAAGTGTTGG
CTTTACTTAATACTGCAAACAATTTAGTTCACCCTCCCCTTATTCCTTATACTGATTTCTATAATTCTACATTGGATCACATTGATCTCA
TGGAAGAATATCATACTTGGCAAAACTTTGGAAACTCTCACAGGTTTTCCTTCTGTCAGTACCCATTCGTTATTTCTGTAGCTGCAAAAA
AAATCATTATTCAGAGAGACTCAGAGCAACAGATGATAAACATCGCAAGGCAAAGTCTGGTGGATAAAGTATCTCGAAGACAGAGACCTG
ATATGAATATATTATTTCTAAATATGAAAGTAAGACGGACACATCTGGTTAGCGATTCACTTGATGAGCTAACCCGGAAAAGAGCCGATT
TGAAAAAGAAGTTAAAAGTTACATTTGTAGGGGAAGCTGGTTTGGATATGGGTGGTTTGACTAAAGAATGGTTCCTTCTTCTAATTCGCC
AAATTTTTCATCCAGATTATGGCATGTTTACATATCACAAGGATTCACACTGCCATTGGTTTAGCAGCTTTAAATGTGATAACTATTCTG
AATTCCGATTGGTTGGAATTCTTATGGGACTAGCTGTTTATAACAGCATCACCTTGGATATTCGTTTCCCTCCCTGCTGTTACAAGAAAT
TATTGAGCCCTCCCATCATTCCTAGTGATCAAAATATACCAGTAGGCATCTGCAATGTTACCGTGGACGACTTATGTCAAATTATGCCTG
AGTTGGCCCATGGATTAAGTGAACTCTTATCACATGAAGGCAATGTTGAAGAAGATTTCTATTCAACATTTCAGGTTTTTCAAGAAGAAT
TTGGAATAATCAAGTCCTATAATTTAAAGCCCGGTGGTGATAAAATTTCAGTTACCAATCAAAATAGAAAAGAATATGTACAGCTTTATA
CTGACTTCCTTCTGAACAAATCCATCTATAAGCAGTTTGCTGCATTTTATTATGGATTTCATAGTGTGTGTGCTTCAAATGCCCTAATGC
TGCTTCGTCCAGAAGAGGTTGAAATTTTGGTCTGTGGAAGTCCTGACCTGGATATGCATGCTCTGCAGAGAAGTACTCAGTATGATGGCT
ATGCAAAAACGGACTTAACTATAAAATACTTTTGGGATGTTGTGCTTGGATTTCCTCTTGATCTTCAAAAGAAGTTGCTACATTTTACTA
CAGGGAGTGACAGAGTACCTGTAGGAGGGATGGCTGATTTGAACTTTAAAATCTCAAAGAATGAAACTTCTACTAACTGCTTACCTGTGG
CCCATACCTGCTTCAATCAACTTTGCCTTCCCCCCTACAAGAGCAAAAAGGATCTGAAACAGAAATTGATCATTGGAATTTCAAATTCAG
AAGGTTTTGGACTTGAGTAACCTAGAAGACTTGAAATATAATCTTTTATATGTAGCATTCACTTCCCTCTTACTGTGCCTTTAGCCTTTT
CATGTTTCTGTCTCAAAACACTTTGACAAAGCTCACCAACTTTAAAATATTAAGTTTTTAAAAAATCAAATATGAAGTATGTTCAGCAAA
GGCATAATTTTCTAAAAACACACACAGAAATCGCTTGAGTGAGGAAAAGTCCACATGGCAGAGACAGGTATGGTCCAGTTCCTCTTTTAT
ATAGCACTTTATCATTCTCCACAAGTAGTTTGTCACAGGCATTCCACTGGGAAAGCAAAGTACAGTGAAGAATGAATTTATGGTATAGTT
GAACCCAGTGGCAGATTGTACACTGCTAGCACTGCTAGCACACAGTAGCAAAGCAAACAGCTACATTATCTTTAACATAAGGCATGTAGC
CATATTTTCATATAGTGGTATACAACACAGTATCATTGCAAATGCAGTTTACAGGGATTTTTGATATACTGGCTTGGGACCTATAAGATT
CTTCTCAGCAGTTGCTGAAAAGCATGTAAATAACTACATAATAGCCTGAGAATAATGGGATTTTGATAGTGCCATTTATTGTTAAAGATT
TATTTTTACAAAGTAAATTCAGGGTTTTAGATGTGTACACAGCTTTTACAAATCAATAAAGATGATTGTACAAGAGTATTTTCAGACTAA
TTGGATTCAAGGTTATATTCTTTTAAGTGTTGTTAGTCTGCATGCACATTGGCAGTAAACTAGTTACTTGTGTACTCTGTAATATTTGTA
TAATGATCATTTCTTCTTAAGGCTCAAGATATTAGAAAAGAAATCAGACCTAAATAATCATTGATGAAGTATGTCAGTTACAAGCACAAA
AGAATATAACTGCTTTTATAAATCTTTTGAATCATGTACAAGACTTATATCTACATTTTTTGATCACCAGTTGTACCAAAACACTAATTT
TTGAAAAAGATAGGTTAAAGTATTTGACAAAAGTGAATACAATAATAACACTTGTGTCAAAATGATATAGCTTAGTATAAAAATAAAATT
CAACGTTTTGGCCAAAATGTTTGTTTTTCACTGGATTCTGAATATAATAAATTCAAAGTACCCTTTTTTTAGAGTTTCTAATAAAGTAGT
ATGTAAAAAGAAACTGCATTTTAAGTCAGACAGTAAATGTTTTTTTTAATTTACAGCAAATGAAGCAGTTTTATTAGCATGTTACAAATA
TTGCCAAACCAAGACTTCTCTACCATACTTTAACAGCTTTCCTTCAGAAAACTCTGAAGTTATATTTGCAATAATAATGAAACCAGCATT
TAGTACCAGCATATGGTTCATATGCAAATAATACTTTCCCCAAAATCTTTCTGGGCTAGGCTATTTTCTTGCTATGCTTCCTGCACCCAA
CCAGCAGAATTCTTCCAGGGTGGAGGAACTAATCAGCTTGTTCTCCAACAGTTCTGAAGCCAACCCACAAATCTTTGAGGAAAAGGGGTC
ACTTTGTTTACTATTCTCTTGGAGATGGAAGTGATTCTGCTCTTCCATTTGGGTATATTATTTCAAGGGTATTTCTTCTTAAAAATCTTG
GAAAGCCTAAGAGAGTTAAAGGCATCCTGGTTTTGTTTCATTTTGCTCTGTTTTAAATCCATATGCAAATAAAACTGCTTCTCTCTTACA
CTGCTTGAACTAGAAAATCAGCTTTTTAATGTAGGTTACCACTTATAAGCACAAAAGAAACATGTATAAGAAACCAGATTTAAGTGTTTT
AAATAAAATGTAAACAGTTTTTATTTGGTAGAGATGACTCATGGAAAAATTGTGTTGGCTTGGTCTGCATGTTTAATGATGTGCTTGTAT
ATCGATTAGCTGTGTCACTTTTAAATAAGAAGTCCACACAAGCAAGCCAAATTTTTAGATGACGAAGTCCATAAATAACTAGAGAATTTT
TGTTATCTGTTGTTAAGTTGAAATGTATAATCATTTATCACTAAATTGCACATTGCCTTTATTTATTTGTGCTCTGTTTTTGGTTTACAG
TGTAATAATACCTCATTTAAAAAATAAAAACCACTACTGTTACATTTTATTAATTTAAAAAGCTAGAAAATTCATGTAGTTACTTTTTTT
ACATATATAATCTGTTAATGAATTATTGATTTTTGTATCTGCCACAGTAAATTAAAGCATTACACAGTATTTATCAGTATTTTTTAAACA
TCCTGTCCTTTTTTAAAATCTTTGCTTAGTCAGTCATATTTTTGTCTGTATGATTAGAAGTTTTTACGTCCTTCCTTTTTTGTACAAATC

>10422_10422_1_BTAF1-HECTD2_BTAF1_chr10_93683847_ENST00000265990_HECTD2_chr10_93240851_ENST00000446394_length(amino acids)=563AA_BP=4
MAVSSPRTKDDLRAYFILLQNPQFNNTSTYVIYAHLLRQIATLVEADHHFLVHWFKKQYSRLSQKRFKQLVERLLQFISLRLFPAKPEEF
PPITKCSWWIPSAAKVLALLNTANNLVHPPLIPYTDFYNSTLDHIDLMEEYHTWQNFGNSHRFSFCQYPFVISVAAKKIIIQRDSEQQMI
NIARQSLVDKVSRRQRPDMNILFLNMKVRRTHLVSDSLDELTRKRADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYH
KDSHCHWFSSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHE
GNVEEDFYSTFQVFQEEFGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRPEEVEILVCG
SPDLDMHALQRSTQYDGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGGMADLNFKISKNETSTNCLPVAHTCFNQLCLPPY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BTAF1-HECTD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BTAF1-HECTD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BTAF1-HECTD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource