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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ASH2L-MLF1IP (FusionGDB2 ID:HG9070TG79682)

Fusion Gene Summary for ASH2L-MLF1IP

check button Fusion gene summary
Fusion gene informationFusion gene name: ASH2L-MLF1IP
Fusion gene ID: hg9070tg79682
HgeneTgene
Gene symbol

ASH2L

MLF1IP

Gene ID

9070

79682

Gene nameASH2 like, histone lysine methyltransferase complex subunitcentromere protein U
SynonymsASH2|ASH2L1|ASH2L2|Bre2CENP50|CENPU50|KLIP1|MLF1IP|PBIP1
Cytomap('ASH2L','ASH2L')('CENPU','MLF1IP')

8p11.23

4q35.1

Type of geneprotein-codingprotein-coding
Descriptionset1/Ash2 histone methyltransferase complex subunit ASH2ASH2-like proteinash2 (absent, small, or homeotic)-likecentromere protein UKSHV latent nuclear antigen interacting protein 1MLF1 interacting proteincentromere protein of 50 kDainterphase centromere complex protein 24polo-box-interacting protein 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000250635, ENST00000343823, 
ENST00000428278, ENST00000521652, 
ENST00000545394, ENST00000524263, 
Fusion gene scores* DoF score13 X 10 X 6=7802 X 2 X 2=8
# samples 142
** MAII scorelog2(14/780*10)=-2.47804729680464
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: ASH2L [Title/Abstract] AND MLF1IP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointASH2L(37978667)-CENPU(185646216), # samples:1
ASH2L(37978667)-MLF1IP(185646216), # samples:1
Anticipated loss of major functional domain due to fusion event.ASH2L-MLF1IP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ASH2L-MLF1IP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ASH2L-MLF1IP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ASH2L-MLF1IP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneASH2L

GO:0006974

cellular response to DNA damage stimulus

17500065

HgeneASH2L

GO:0043627

response to estrogen

16603732

HgeneASH2L

GO:0051568

histone H3-K4 methylation

17355966|19556245


check buttonFusion gene breakpoints across ASH2L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MLF1IP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-R6-A8W5-01BASH2Lchr8

37978667

+CENPUchr4

185646216

-
ChimerDB4ESCATCGA-R6-A8W5ASH2Lchr8

37978667

+MLF1IPchr4

185646216

-


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Fusion Gene ORF analysis for ASH2L-MLF1IP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000250635ENST00000506535ASH2Lchr8

37978667

+MLF1IPchr4

185646216

-
5CDS-intronENST00000250635ENST00000541971ASH2Lchr8

37978667

+MLF1IPchr4

185646216

-
5CDS-intronENST00000343823ENST00000506535ASH2Lchr8

37978667

+MLF1IPchr4

185646216

-
5CDS-intronENST00000343823ENST00000541971ASH2Lchr8

37978667

+MLF1IPchr4

185646216

-
5CDS-intronENST00000428278ENST00000506535ASH2Lchr8

37978667

+MLF1IPchr4

185646216

-
5CDS-intronENST00000428278ENST00000541971ASH2Lchr8

37978667

+MLF1IPchr4

185646216

-
5CDS-intronENST00000521652ENST00000506535ASH2Lchr8

37978667

+MLF1IPchr4

185646216

-
5CDS-intronENST00000521652ENST00000541971ASH2Lchr8

37978667

+MLF1IPchr4

185646216

-
5CDS-intronENST00000545394ENST00000506535ASH2Lchr8

37978667

+MLF1IPchr4

185646216

-
5CDS-intronENST00000545394ENST00000541971ASH2Lchr8

37978667

+MLF1IPchr4

185646216

-
In-frameENST00000250635ENST00000281453ASH2Lchr8

37978667

+MLF1IPchr4

185646216

-
In-frameENST00000343823ENST00000281453ASH2Lchr8

37978667

+MLF1IPchr4

185646216

-
In-frameENST00000428278ENST00000281453ASH2Lchr8

37978667

+MLF1IPchr4

185646216

-
In-frameENST00000521652ENST00000281453ASH2Lchr8

37978667

+MLF1IPchr4

185646216

-
In-frameENST00000545394ENST00000281453ASH2Lchr8

37978667

+MLF1IPchr4

185646216

-
intron-3CDSENST00000524263ENST00000281453ASH2Lchr8

37978667

+MLF1IPchr4

185646216

-
intron-intronENST00000524263ENST00000506535ASH2Lchr8

37978667

+MLF1IPchr4

185646216

-
intron-intronENST00000524263ENST00000541971ASH2Lchr8

37978667

+MLF1IPchr4

185646216

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000343823ASH2Lchr837978667+ENST00000281453MLF1IPchr4185646216-318714743092516735
ENST00000250635ASH2Lchr837978667+ENST00000281453MLF1IPchr4185646216-29361223582265735
ENST00000545394ASH2Lchr837978667+ENST00000281453MLF1IPchr4185646216-273310202722062596
ENST00000428278ASH2Lchr837978667+ENST00000281453MLF1IPchr4185646216-303713243572366669
ENST00000521652ASH2Lchr837978667+ENST00000281453MLF1IPchr4185646216-289111782112220669

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000343823ENST00000281453ASH2Lchr837978667+MLF1IPchr4185646216-0.0020930260.99790704
ENST00000250635ENST00000281453ASH2Lchr837978667+MLF1IPchr4185646216-0.0023688230.9976312
ENST00000545394ENST00000281453ASH2Lchr837978667+MLF1IPchr4185646216-0.0011325280.9988675
ENST00000428278ENST00000281453ASH2Lchr837978667+MLF1IPchr4185646216-0.0018999330.9981001
ENST00000521652ENST00000281453ASH2Lchr837978667+MLF1IPchr4185646216-0.0018731140.9981269

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Fusion Genomic Features for ASH2L-MLF1IP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ASH2L-MLF1IP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:37978667/chr4:185646216)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASH2Lchr8:37978667chr4:185646216ENST00000250635+101567_177294502.0RegionNote=DNA-binding
HgeneASH2Lchr8:37978667chr4:185646216ENST00000343823+101667_177388629.0RegionNote=DNA-binding
HgeneASH2Lchr8:37978667chr4:185646216ENST00000428278+101667_177294535.0RegionNote=DNA-binding
HgeneASH2Lchr8:37978667chr4:185646216ENST00000521652+101567_177294502.0RegionNote=DNA-binding
HgeneASH2Lchr8:37978667chr4:185646216ENST00000250635+1015117_150294502.0Zinc fingerNote=C4-type
HgeneASH2Lchr8:37978667chr4:185646216ENST00000250635+10151_66294502.0Zinc fingerNote=PHD-type%3B atypical
HgeneASH2Lchr8:37978667chr4:185646216ENST00000343823+1016117_150388629.0Zinc fingerNote=C4-type
HgeneASH2Lchr8:37978667chr4:185646216ENST00000343823+10161_66388629.0Zinc fingerNote=PHD-type%3B atypical
HgeneASH2Lchr8:37978667chr4:185646216ENST00000428278+1016117_150294535.0Zinc fingerNote=C4-type
HgeneASH2Lchr8:37978667chr4:185646216ENST00000428278+10161_66294535.0Zinc fingerNote=PHD-type%3B atypical
HgeneASH2Lchr8:37978667chr4:185646216ENST00000521652+1015117_150294502.0Zinc fingerNote=C4-type
HgeneASH2Lchr8:37978667chr4:185646216ENST00000521652+10151_66294502.0Zinc fingerNote=PHD-type%3B atypical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASH2Lchr8:37978667chr4:185646216ENST00000250635+1015360_583294502.0DomainB30.2/SPRY
HgeneASH2Lchr8:37978667chr4:185646216ENST00000343823+1016360_583388629.0DomainB30.2/SPRY
HgeneASH2Lchr8:37978667chr4:185646216ENST00000428278+1016360_583294535.0DomainB30.2/SPRY
HgeneASH2Lchr8:37978667chr4:185646216ENST00000521652+1015360_583294502.0DomainB30.2/SPRY


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Fusion Gene Sequence for ASH2L-MLF1IP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7132_7132_1_ASH2L-MLF1IP_ASH2L_chr8_37978667_ENST00000250635_MLF1IP_chr4_185646216_ENST00000281453_length(transcript)=2936nt_BP=1223nt
CACAGCAACGCGCGCGAGAGAAGAGAGTATTCTCGCGAGAAGTCCAGGGGTGGCCGTGATGGCGGCGGCAGGAGCAGGACCTGGCCAGGA
AGCGGGTGCCGGGCCTGGCCCAGGAGCGGTCGCAAATGCAACAGGGGCAGAAGAGGGGGAGATGAAGCCGGTGGCAGCGGGAGCAGCCGC
TCCTCCTGGAGAGGGGATCTCTGCTGCTCCGACAGTTGAGCCCAGTTCCGGGGAGGCTGAAGGCGGGGAGGCAAACTTGGTCGATGTAAG
CGGTGGCTTGGAGACAGAATCATCTAATGGAAAAGATACACTAGAAGGTGCTGGGGATACATCAGAGGTGATGGATACTCAGGCGGGCTC
CGTGGATGAAGAGAATGGCCGACAGTTGGGTGAGGTAGAGCTGCAATGTGGGATTTGTACAAAATGGTTCACGGCTGACACATTTGGCAT
AGATACCTCATCCTGTCTACCTTTCATGACCAACTACAGTTTTCATTGCAACGTCTGCCATCACAGTGGGAATACCTATTTCCTCCGGAA
GCAAGCAAACTTGAAGGAAATGTGCCTTAGTGCTTTGGCCAACCTGACATGGCAGTCCCGAACACAGGATGAACATCCGAAGACAATGTT
CTCCAAAGATAAGGATATTATACCATTTATTGATAAATACTGGGAGTGCATGACAACCAGACAGAGACCTGGGAAAATGACTTGGCCAAA
TAACATTGTTAAAACAATGAGTAAAGAAAGAGATGTATTCTTGGTAAAGGAACACCCAGATCCAGGCAGTAAAGATCCAGAAGAAGATTA
CCCCAAATTTGGACTTTTGGATCAGGACCTTAGTAACATTGGTCCTGCTTATGACAACCAAAAACAGAGCAGTGCTGTGTCTACTAGTGG
GAATTTAAATGGGGGAATTGCAGCAGGAAGCAGCGGAAAAGGACGAGGAGCCAAGCGCAAACAGCAGGATGGAGGGACCACAGGGACCAC
CAAGAAGGCCCGGAGTGACCCTTTGTTTTCTGCTCAGCGCCTTCCCCCTCATGGCTACCCATTGGAACACCCGTTTAACAAAGATGGCTA
TCGGTATATTCTAGCTGAGCCTGATCCGCACGCCCCTGACCCCGAGAAGCTGGAACTTGACTGCTGGGCAGGAAAACCTATTCCTGGAGA
CCTCTACAGAGCCTGCTTGTATGAACGGGTTTTGTTAGCCCTACATGATCGAGATCCTCCTTTACATAGCACAGCTATATATGCTGATGA
AGAAGAATTCTCCAAACATTGTGGACTGTCTCTCTCTTCAACTCCTCCAGGAAAAGAAGCAAAAAGAAGTTCAGACACTTCTGGAAATGA
AGCAAGTGAAATCGAATCTGTAAAAATTAGTGCAAAAAAGCCAGGAAGAAAGCTCAGGCCCATTAGTGATGACTCTGAAAGCATTGAAGA
AAGTGATACAAGGAGAAAAGTTAAATCAGCAGAGAAAATAAGTACACAACGTCATGAGGTTATTCGAACCACAGCGTCTTCAGAACTTTC
AGAGAAACCAGCTGAGTCTGTCACTTCTAAAAAGACAGGACCCCTTAGTGCCCAGCCCTCTGTTGAAAAAGAGAACTTGGCAATAGAAAG
TCAATCGAAAACTCAGAAAAAAGGGAAGATATCTCATGACAAAAGGAAGAAATCAAGAAGTAAAGCCATAGGCTCAGATACTTCTGACAT
TGTGCACATTTGGTGTCCAGAAGGAATGAAAACCAGTGACATCAAGGAGTTGAATATTGTTTTGCCTGAATTTGAGAAAACCCACCTAGA
GCATCAACAAAGAATAGAATCTAAAGTTTGTAAGGCAGCCATCGCCACATTTTATGTTAATGTTAAAGAACAATTCATCAAAATGCTTAA
AGAAAGCCAGATGTTGACAAATCTGAAAAGGAAGAATGCTAAGATGATTTCAGATATCGAAAAGAAAAGGCAGCGTATGATTGAAGTCCA
GGATGAACTGCTTCGGTTAGAGCCACAGCTGAAACAACTACAAACAAAATATGATGAACTTAAAGAGAGAAAGTCTTCCCTTAGGAATGC
AGCATATTTCTTATCTAATTTAAAACAGCTTTATCAAGATTATTCAGATGTTCAAGCTCAAGAACCAAACGTAAAGGAAACGTATGATTC
ATCCAGCCTTCCAGCTCTGTTATTTAAAGCAAGAACACTTCTGGGAGCCGAAAGCCATCTGCGAAATATCAACCATCAGTTAGAGAAGCT
CCTTGACCAGGGATGAGAAGAGCAGTCTACTAAAATGTGCCTATAGGAAGACTAGTCTCATGCTGTTACCTTCTGAAACTGTACCTTTAT
AAATCAATTGTTTTGCAAAGAAGTTATGGCCTACTTAGAATCTAAAATTTGTTATTCAAATTAAATGGCTGTGAACAATGTTAAATAGCA
TCAGTTTGTCCAATAGTTTTAAAGGCCATAATCATCTTTTCTGGTTAATATCTTGAGTAATTTTAAAATGTTGACACCTTAATCGGTCCC
AGGTATGAGCTATAATAAACTTGTAAAATTAAGTTGATGTGAACATAATTTTGATTAATTAATAAGGCGATTTCTCCTGAATTTACACCA
AAGCTAATTTTTAATGAAATTGGTTTACAGAAGTAAAAAACAAAAATTGGAAAGCAAAGTAATAAAACTTAGTTTATATAAACAGGTTGA
ATGATATATTTATCAAATCTCACAGACATCAGGCAAATTATAGCCTGGTGACAAAAGTGTTCATAGTGAATTAGTTACTCTTGTAATACT
TCTATAATTAGTTCATCAGGAATTTCATCCACTTCACTGTTATAACTGAGAAGACTGTTCTCTGCAGCTTCAGCTAATTCAGCATCTTCA

>7132_7132_1_ASH2L-MLF1IP_ASH2L_chr8_37978667_ENST00000250635_MLF1IP_chr4_185646216_ENST00000281453_length(amino acids)=735AA_BP=380
MAAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGD
TSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQS
RTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDN
QKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLEL
DCWAGKPIPGDLYRACLYERVLLALHDRDPPLHSTAIYADEEEFSKHCGLSLSSTPPGKEAKRSSDTSGNEASEIESVKISAKKPGRKLR
PISDDSESIEESDTRRKVKSAEKISTQRHEVIRTTASSELSEKPAESVTSKKTGPLSAQPSVEKENLAIESQSKTQKKGKISHDKRKKSR
SKAIGSDTSDIVHIWCPEGMKTSDIKELNIVLPEFEKTHLEHQQRIESKVCKAAIATFYVNVKEQFIKMLKESQMLTNLKRKNAKMISDI
EKKRQRMIEVQDELLRLEPQLKQLQTKYDELKERKSSLRNAAYFLSNLKQLYQDYSDVQAQEPNVKETYDSSSLPALLFKARTLLGAESH

--------------------------------------------------------------
>7132_7132_2_ASH2L-MLF1IP_ASH2L_chr8_37978667_ENST00000343823_MLF1IP_chr4_185646216_ENST00000281453_length(transcript)=3187nt_BP=1474nt
GCAGAATATCCAGTCGTAGCCACGAAAATACGCCGCGTCAGTCCCTGACTCGAAAGGAAGTCCTCCAGAGAGCCGCACTAACCATCTAGC
TTCCTCCACCTTCAGCCTGCCAGGCCCGCGGCCACCGCCGGCGCGGGAGGCCGGCCCACCTCTGCCCGCGCGCCTGGCCTTAAAGCGGTC
GTGGAATTATGCTTCCTCAGGCAGGCGGTGGACGCACCGCGGGCTTTTTCTGTTTGAAGACTACAGCGTCACACAGCAACGCGCGCGAGA
GAAGAGAGTATTCTCGCGAGAAGTCCAGGGGTGGCCGTGATGGCGGCGGCAGGAGCAGGACCTGGCCAGGAAGCGGGTGCCGGGCCTGGC
CCAGGAGCGGTCGCAAATGCAACAGGGGCAGAAGAGGGGGAGATGAAGCCGGTGGCAGCGGGAGCAGCCGCTCCTCCTGGAGAGGGGATC
TCTGCTGCTCCGACAGTTGAGCCCAGTTCCGGGGAGGCTGAAGGCGGGGAGGCAAACTTGGTCGATGTAAGCGGTGGCTTGGAGACAGAA
TCATCTAATGGAAAAGATACACTAGAAGGTGCTGGGGATACATCAGAGGTGATGGATACTCAGGCGGGCTCCGTGGATGAAGAGAATGGC
CGACAGTTGGGTGAGGTAGAGCTGCAATGTGGGATTTGTACAAAATGGTTCACGGCTGACACATTTGGCATAGATACCTCATCCTGTCTA
CCTTTCATGACCAACTACAGTTTTCATTGCAACGTCTGCCATCACAGTGGGAATACCTATTTCCTCCGGAAGCAAGCAAACTTGAAGGAA
ATGTGCCTTAGTGCTTTGGCCAACCTGACATGGCAGTCCCGAACACAGGATGAACATCCGAAGACAATGTTCTCCAAAGATAAGGATATT
ATACCATTTATTGATAAATACTGGGAGTGCATGACAACCAGACAGAGACCTGGGAAAATGACTTGGCCAAATAACATTGTTAAAACAATG
AGTAAAGAAAGAGATGTATTCTTGGTAAAGGAACACCCAGATCCAGGCAGTAAAGATCCAGAAGAAGATTACCCCAAATTTGGACTTTTG
GATCAGGACCTTAGTAACATTGGTCCTGCTTATGACAACCAAAAACAGAGCAGTGCTGTGTCTACTAGTGGGAATTTAAATGGGGGAATT
GCAGCAGGAAGCAGCGGAAAAGGACGAGGAGCCAAGCGCAAACAGCAGGATGGAGGGACCACAGGGACCACCAAGAAGGCCCGGAGTGAC
CCTTTGTTTTCTGCTCAGCGCCTTCCCCCTCATGGCTACCCATTGGAACACCCGTTTAACAAAGATGGCTATCGGTATATTCTAGCTGAG
CCTGATCCGCACGCCCCTGACCCCGAGAAGCTGGAACTTGACTGCTGGGCAGGAAAACCTATTCCTGGAGACCTCTACAGAGCCTGCTTG
TATGAACGGGTTTTGTTAGCCCTACATGATCGAGATCCTCCTTTACATAGCACAGCTATATATGCTGATGAAGAAGAATTCTCCAAACAT
TGTGGACTGTCTCTCTCTTCAACTCCTCCAGGAAAAGAAGCAAAAAGAAGTTCAGACACTTCTGGAAATGAAGCAAGTGAAATCGAATCT
GTAAAAATTAGTGCAAAAAAGCCAGGAAGAAAGCTCAGGCCCATTAGTGATGACTCTGAAAGCATTGAAGAAAGTGATACAAGGAGAAAA
GTTAAATCAGCAGAGAAAATAAGTACACAACGTCATGAGGTTATTCGAACCACAGCGTCTTCAGAACTTTCAGAGAAACCAGCTGAGTCT
GTCACTTCTAAAAAGACAGGACCCCTTAGTGCCCAGCCCTCTGTTGAAAAAGAGAACTTGGCAATAGAAAGTCAATCGAAAACTCAGAAA
AAAGGGAAGATATCTCATGACAAAAGGAAGAAATCAAGAAGTAAAGCCATAGGCTCAGATACTTCTGACATTGTGCACATTTGGTGTCCA
GAAGGAATGAAAACCAGTGACATCAAGGAGTTGAATATTGTTTTGCCTGAATTTGAGAAAACCCACCTAGAGCATCAACAAAGAATAGAA
TCTAAAGTTTGTAAGGCAGCCATCGCCACATTTTATGTTAATGTTAAAGAACAATTCATCAAAATGCTTAAAGAAAGCCAGATGTTGACA
AATCTGAAAAGGAAGAATGCTAAGATGATTTCAGATATCGAAAAGAAAAGGCAGCGTATGATTGAAGTCCAGGATGAACTGCTTCGGTTA
GAGCCACAGCTGAAACAACTACAAACAAAATATGATGAACTTAAAGAGAGAAAGTCTTCCCTTAGGAATGCAGCATATTTCTTATCTAAT
TTAAAACAGCTTTATCAAGATTATTCAGATGTTCAAGCTCAAGAACCAAACGTAAAGGAAACGTATGATTCATCCAGCCTTCCAGCTCTG
TTATTTAAAGCAAGAACACTTCTGGGAGCCGAAAGCCATCTGCGAAATATCAACCATCAGTTAGAGAAGCTCCTTGACCAGGGATGAGAA
GAGCAGTCTACTAAAATGTGCCTATAGGAAGACTAGTCTCATGCTGTTACCTTCTGAAACTGTACCTTTATAAATCAATTGTTTTGCAAA
GAAGTTATGGCCTACTTAGAATCTAAAATTTGTTATTCAAATTAAATGGCTGTGAACAATGTTAAATAGCATCAGTTTGTCCAATAGTTT
TAAAGGCCATAATCATCTTTTCTGGTTAATATCTTGAGTAATTTTAAAATGTTGACACCTTAATCGGTCCCAGGTATGAGCTATAATAAA
CTTGTAAAATTAAGTTGATGTGAACATAATTTTGATTAATTAATAAGGCGATTTCTCCTGAATTTACACCAAAGCTAATTTTTAATGAAA
TTGGTTTACAGAAGTAAAAAACAAAAATTGGAAAGCAAAGTAATAAAACTTAGTTTATATAAACAGGTTGAATGATATATTTATCAAATC
TCACAGACATCAGGCAAATTATAGCCTGGTGACAAAAGTGTTCATAGTGAATTAGTTACTCTTGTAATACTTCTATAATTAGTTCATCAG
GAATTTCATCCACTTCACTGTTATAACTGAGAAGACTGTTCTCTGCAGCTTCAGCTAATTCAGCATCTTCAGTAGCTTCTAAAAAATAAG

>7132_7132_2_ASH2L-MLF1IP_ASH2L_chr8_37978667_ENST00000343823_MLF1IP_chr4_185646216_ENST00000281453_length(amino acids)=735AA_BP=380
MAAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGD
TSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQS
RTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDN
QKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLEL
DCWAGKPIPGDLYRACLYERVLLALHDRDPPLHSTAIYADEEEFSKHCGLSLSSTPPGKEAKRSSDTSGNEASEIESVKISAKKPGRKLR
PISDDSESIEESDTRRKVKSAEKISTQRHEVIRTTASSELSEKPAESVTSKKTGPLSAQPSVEKENLAIESQSKTQKKGKISHDKRKKSR
SKAIGSDTSDIVHIWCPEGMKTSDIKELNIVLPEFEKTHLEHQQRIESKVCKAAIATFYVNVKEQFIKMLKESQMLTNLKRKNAKMISDI
EKKRQRMIEVQDELLRLEPQLKQLQTKYDELKERKSSLRNAAYFLSNLKQLYQDYSDVQAQEPNVKETYDSSSLPALLFKARTLLGAESH

--------------------------------------------------------------
>7132_7132_3_ASH2L-MLF1IP_ASH2L_chr8_37978667_ENST00000428278_MLF1IP_chr4_185646216_ENST00000281453_length(transcript)=3037nt_BP=1324nt
ATCCCGCGGCTCCTGGAGCCCTGCCGCCCGCCCCCTGCGAACCCAGGCCCCGCCGCCAATGGCTCGCCCTGCCTCTGCGCCGCTTGGCCC
GTCCCCTCTCAAGCATATCTCGGATAACGCCCCTTCCGCACCTTTCACGGGCGGTGGGAGCTGAGGCTCCTGTCGTTATCTCTGATCCTT
GCACCCTGGCAGGAAGCTGGTAGCTCACACTTTAACGGGAGGCCTTCACATATTCCAGAAAAGAAACCACTTTGCAGTGCCAGACTGGAA
GAAGTAACGGTCACTCTGAAAACAGGGTGGGAGAGCTGCCTCTCTTTGAACCTCTCCCAGGACCAACTCTAACCCAGGGAGGCAAACTTG
GTCGATGTAAGCGGTGGCTTGGAGACAGAATCATCTAATGGAAAAGATACACTAGAAGGTGCTGGGGATACATCAGAGGTGATGGATACT
CAGGCGGGCTCCGTGGATGAAGAGAATGGCCGACAGTTGGGTGAGGTAGAGCTGCAATGTGGGATTTGTACAAAATGGTTCACGGCTGAC
ACATTTGGCATAGATACCTCATCCTGTCTACCTTTCATGACCAACTACAGTTTTCATTGCAACGTCTGCCATCACAGTGGGAATACCTAT
TTCCTCCGGAAGCAAGCAAACTTGAAGGAAATGTGCCTTAGTGCTTTGGCCAACCTGACATGGCAGTCCCGAACACAGGATGAACATCCG
AAGACAATGTTCTCCAAAGATAAGGATATTATACCATTTATTGATAAATACTGGGAGTGCATGACAACCAGACAGAGACCTGGGAAAATG
ACTTGGCCAAATAACATTGTTAAAACAATGAGTAAAGAAAGAGATGTATTCTTGGTAAAGGAACACCCAGATCCAGGCAGTAAAGATCCA
GAAGAAGATTACCCCAAATTTGGACTTTTGGATCAGGACCTTAGTAACATTGGTCCTGCTTATGACAACCAAAAACAGAGCAGTGCTGTG
TCTACTAGTGGGAATTTAAATGGGGGAATTGCAGCAGGAAGCAGCGGAAAAGGACGAGGAGCCAAGCGCAAACAGCAGGATGGAGGGACC
ACAGGGACCACCAAGAAGGCCCGGAGTGACCCTTTGTTTTCTGCTCAGCGCCTTCCCCCTCATGGCTACCCATTGGAACACCCGTTTAAC
AAAGATGGCTATCGGTATATTCTAGCTGAGCCTGATCCGCACGCCCCTGACCCCGAGAAGCTGGAACTTGACTGCTGGGCAGGAAAACCT
ATTCCTGGAGACCTCTACAGAGCCTGCTTGTATGAACGGGTTTTGTTAGCCCTACATGATCGAGATCCTCCTTTACATAGCACAGCTATA
TATGCTGATGAAGAAGAATTCTCCAAACATTGTGGACTGTCTCTCTCTTCAACTCCTCCAGGAAAAGAAGCAAAAAGAAGTTCAGACACT
TCTGGAAATGAAGCAAGTGAAATCGAATCTGTAAAAATTAGTGCAAAAAAGCCAGGAAGAAAGCTCAGGCCCATTAGTGATGACTCTGAA
AGCATTGAAGAAAGTGATACAAGGAGAAAAGTTAAATCAGCAGAGAAAATAAGTACACAACGTCATGAGGTTATTCGAACCACAGCGTCT
TCAGAACTTTCAGAGAAACCAGCTGAGTCTGTCACTTCTAAAAAGACAGGACCCCTTAGTGCCCAGCCCTCTGTTGAAAAAGAGAACTTG
GCAATAGAAAGTCAATCGAAAACTCAGAAAAAAGGGAAGATATCTCATGACAAAAGGAAGAAATCAAGAAGTAAAGCCATAGGCTCAGAT
ACTTCTGACATTGTGCACATTTGGTGTCCAGAAGGAATGAAAACCAGTGACATCAAGGAGTTGAATATTGTTTTGCCTGAATTTGAGAAA
ACCCACCTAGAGCATCAACAAAGAATAGAATCTAAAGTTTGTAAGGCAGCCATCGCCACATTTTATGTTAATGTTAAAGAACAATTCATC
AAAATGCTTAAAGAAAGCCAGATGTTGACAAATCTGAAAAGGAAGAATGCTAAGATGATTTCAGATATCGAAAAGAAAAGGCAGCGTATG
ATTGAAGTCCAGGATGAACTGCTTCGGTTAGAGCCACAGCTGAAACAACTACAAACAAAATATGATGAACTTAAAGAGAGAAAGTCTTCC
CTTAGGAATGCAGCATATTTCTTATCTAATTTAAAACAGCTTTATCAAGATTATTCAGATGTTCAAGCTCAAGAACCAAACGTAAAGGAA
ACGTATGATTCATCCAGCCTTCCAGCTCTGTTATTTAAAGCAAGAACACTTCTGGGAGCCGAAAGCCATCTGCGAAATATCAACCATCAG
TTAGAGAAGCTCCTTGACCAGGGATGAGAAGAGCAGTCTACTAAAATGTGCCTATAGGAAGACTAGTCTCATGCTGTTACCTTCTGAAAC
TGTACCTTTATAAATCAATTGTTTTGCAAAGAAGTTATGGCCTACTTAGAATCTAAAATTTGTTATTCAAATTAAATGGCTGTGAACAAT
GTTAAATAGCATCAGTTTGTCCAATAGTTTTAAAGGCCATAATCATCTTTTCTGGTTAATATCTTGAGTAATTTTAAAATGTTGACACCT
TAATCGGTCCCAGGTATGAGCTATAATAAACTTGTAAAATTAAGTTGATGTGAACATAATTTTGATTAATTAATAAGGCGATTTCTCCTG
AATTTACACCAAAGCTAATTTTTAATGAAATTGGTTTACAGAAGTAAAAAACAAAAATTGGAAAGCAAAGTAATAAAACTTAGTTTATAT
AAACAGGTTGAATGATATATTTATCAAATCTCACAGACATCAGGCAAATTATAGCCTGGTGACAAAAGTGTTCATAGTGAATTAGTTACT
CTTGTAATACTTCTATAATTAGTTCATCAGGAATTTCATCCACTTCACTGTTATAACTGAGAAGACTGTTCTCTGCAGCTTCAGCTAATT

>7132_7132_3_ASH2L-MLF1IP_ASH2L_chr8_37978667_ENST00000428278_MLF1IP_chr4_185646216_ENST00000281453_length(amino acids)=669AA_BP=314
MVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNT
YFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKD
PEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPF
NKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRDPPLHSTAIYADEEEFSKHCGLSLSSTPPGKEAKRSSD
TSGNEASEIESVKISAKKPGRKLRPISDDSESIEESDTRRKVKSAEKISTQRHEVIRTTASSELSEKPAESVTSKKTGPLSAQPSVEKEN
LAIESQSKTQKKGKISHDKRKKSRSKAIGSDTSDIVHIWCPEGMKTSDIKELNIVLPEFEKTHLEHQQRIESKVCKAAIATFYVNVKEQF
IKMLKESQMLTNLKRKNAKMISDIEKKRQRMIEVQDELLRLEPQLKQLQTKYDELKERKSSLRNAAYFLSNLKQLYQDYSDVQAQEPNVK

--------------------------------------------------------------
>7132_7132_4_ASH2L-MLF1IP_ASH2L_chr8_37978667_ENST00000521652_MLF1IP_chr4_185646216_ENST00000281453_length(transcript)=2891nt_BP=1178nt
GGAGCTGAGGCTCCTGTCGTTATCTCTGATCCTTGCACCCTGGCAGGAAGCTGGTAGCTCACACTTTAACGGGAGGCCTTCACATATTCC
AGAAAAGAAACCACTTTGCAGTGCCAGACTGGAAGAAGTAACGGTCACTCTGAAAACAGGGTGGGAGAGCTGCCTCTCTTTGAACCTCTC
CCAGGACCAACTCTAACCCAGGGAGGCAAACTTGGTCGATGTAAGCGGTGGCTTGGAGACAGAATCATCTAATGGAAAAGATACACTAGA
AGGTGCTGGGGATACATCAGAGGTGATGGATACTCAGGCGGGCTCCGTGGATGAAGAGAATGGCCGACAGTTGGGTGAGGTAGAGCTGCA
ATGTGGGATTTGTACAAAATGGTTCACGGCTGACACATTTGGCATAGATACCTCATCCTGTCTACCTTTCATGACCAACTACAGTTTTCA
TTGCAACGTCTGCCATCACAGTGGGAATACCTATTTCCTCCGGAAGCAAGCAAACTTGAAGGAAATGTGCCTTAGTGCTTTGGCCAACCT
GACATGGCAGTCCCGAACACAGGATGAACATCCGAAGACAATGTTCTCCAAAGATAAGGATATTATACCATTTATTGATAAATACTGGGA
GTGCATGACAACCAGACAGAGACCTGGGAAAATGACTTGGCCAAATAACATTGTTAAAACAATGAGTAAAGAAAGAGATGTATTCTTGGT
AAAGGAACACCCAGATCCAGGCAGTAAAGATCCAGAAGAAGATTACCCCAAATTTGGACTTTTGGATCAGGACCTTAGTAACATTGGTCC
TGCTTATGACAACCAAAAACAGAGCAGTGCTGTGTCTACTAGTGGGAATTTAAATGGGGGAATTGCAGCAGGAAGCAGCGGAAAAGGACG
AGGAGCCAAGCGCAAACAGCAGGATGGAGGGACCACAGGGACCACCAAGAAGGCCCGGAGTGACCCTTTGTTTTCTGCTCAGCGCCTTCC
CCCTCATGGCTACCCATTGGAACACCCGTTTAACAAAGATGGCTATCGGTATATTCTAGCTGAGCCTGATCCGCACGCCCCTGACCCCGA
GAAGCTGGAACTTGACTGCTGGGCAGGAAAACCTATTCCTGGAGACCTCTACAGAGCCTGCTTGTATGAACGGGTTTTGTTAGCCCTACA
TGATCGAGATCCTCCTTTACATAGCACAGCTATATATGCTGATGAAGAAGAATTCTCCAAACATTGTGGACTGTCTCTCTCTTCAACTCC
TCCAGGAAAAGAAGCAAAAAGAAGTTCAGACACTTCTGGAAATGAAGCAAGTGAAATCGAATCTGTAAAAATTAGTGCAAAAAAGCCAGG
AAGAAAGCTCAGGCCCATTAGTGATGACTCTGAAAGCATTGAAGAAAGTGATACAAGGAGAAAAGTTAAATCAGCAGAGAAAATAAGTAC
ACAACGTCATGAGGTTATTCGAACCACAGCGTCTTCAGAACTTTCAGAGAAACCAGCTGAGTCTGTCACTTCTAAAAAGACAGGACCCCT
TAGTGCCCAGCCCTCTGTTGAAAAAGAGAACTTGGCAATAGAAAGTCAATCGAAAACTCAGAAAAAAGGGAAGATATCTCATGACAAAAG
GAAGAAATCAAGAAGTAAAGCCATAGGCTCAGATACTTCTGACATTGTGCACATTTGGTGTCCAGAAGGAATGAAAACCAGTGACATCAA
GGAGTTGAATATTGTTTTGCCTGAATTTGAGAAAACCCACCTAGAGCATCAACAAAGAATAGAATCTAAAGTTTGTAAGGCAGCCATCGC
CACATTTTATGTTAATGTTAAAGAACAATTCATCAAAATGCTTAAAGAAAGCCAGATGTTGACAAATCTGAAAAGGAAGAATGCTAAGAT
GATTTCAGATATCGAAAAGAAAAGGCAGCGTATGATTGAAGTCCAGGATGAACTGCTTCGGTTAGAGCCACAGCTGAAACAACTACAAAC
AAAATATGATGAACTTAAAGAGAGAAAGTCTTCCCTTAGGAATGCAGCATATTTCTTATCTAATTTAAAACAGCTTTATCAAGATTATTC
AGATGTTCAAGCTCAAGAACCAAACGTAAAGGAAACGTATGATTCATCCAGCCTTCCAGCTCTGTTATTTAAAGCAAGAACACTTCTGGG
AGCCGAAAGCCATCTGCGAAATATCAACCATCAGTTAGAGAAGCTCCTTGACCAGGGATGAGAAGAGCAGTCTACTAAAATGTGCCTATA
GGAAGACTAGTCTCATGCTGTTACCTTCTGAAACTGTACCTTTATAAATCAATTGTTTTGCAAAGAAGTTATGGCCTACTTAGAATCTAA
AATTTGTTATTCAAATTAAATGGCTGTGAACAATGTTAAATAGCATCAGTTTGTCCAATAGTTTTAAAGGCCATAATCATCTTTTCTGGT
TAATATCTTGAGTAATTTTAAAATGTTGACACCTTAATCGGTCCCAGGTATGAGCTATAATAAACTTGTAAAATTAAGTTGATGTGAACA
TAATTTTGATTAATTAATAAGGCGATTTCTCCTGAATTTACACCAAAGCTAATTTTTAATGAAATTGGTTTACAGAAGTAAAAAACAAAA
ATTGGAAAGCAAAGTAATAAAACTTAGTTTATATAAACAGGTTGAATGATATATTTATCAAATCTCACAGACATCAGGCAAATTATAGCC
TGGTGACAAAAGTGTTCATAGTGAATTAGTTACTCTTGTAATACTTCTATAATTAGTTCATCAGGAATTTCATCCACTTCACTGTTATAA
CTGAGAAGACTGTTCTCTGCAGCTTCAGCTAATTCAGCATCTTCAGTAGCTTCTAAAAAATAAGCATCATCAATGCCATTATCCCAGACA

>7132_7132_4_ASH2L-MLF1IP_ASH2L_chr8_37978667_ENST00000521652_MLF1IP_chr4_185646216_ENST00000281453_length(amino acids)=669AA_BP=314
MVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNT
YFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKD
PEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPF
NKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRDPPLHSTAIYADEEEFSKHCGLSLSSTPPGKEAKRSSD
TSGNEASEIESVKISAKKPGRKLRPISDDSESIEESDTRRKVKSAEKISTQRHEVIRTTASSELSEKPAESVTSKKTGPLSAQPSVEKEN
LAIESQSKTQKKGKISHDKRKKSRSKAIGSDTSDIVHIWCPEGMKTSDIKELNIVLPEFEKTHLEHQQRIESKVCKAAIATFYVNVKEQF
IKMLKESQMLTNLKRKNAKMISDIEKKRQRMIEVQDELLRLEPQLKQLQTKYDELKERKSSLRNAAYFLSNLKQLYQDYSDVQAQEPNVK

--------------------------------------------------------------
>7132_7132_5_ASH2L-MLF1IP_ASH2L_chr8_37978667_ENST00000545394_MLF1IP_chr4_185646216_ENST00000281453_length(transcript)=2733nt_BP=1020nt
GATGGCGGCGGCAGGAGCAGGACCTGGCCAGGAAGCGGGTGCCGGGCCTGGCCCAGGAGCGGTCGCAAATGCAACAGGGGCAGAAGAGGG
GGAGATGAAGCCGGTGGCAGCGGGAGCAGCCGCTCCTCCTGGAGAGGGGATCTCTGCTGCTCCGACAGTTGAGCCCAGTTCCGGGGAGGC
TGAAGGCGGGGAGGCAAACTTGGTCGATGTAAGCGGTGGCTTGGAGACAGAATCATCTAATGGAAAAGATACACTAATCCTGTCTACCTT
TCATGACCAACTACAGTTTTCATTGCAACGTCTGCCATCACAGTGGGAATACCTATTTCCTCCGGAAGCAAGCAAACTTGAAGGAAATGT
GCCTTAGTGCTTTGGCCAACCTGACATGGCAGTCCCGAACACAGGATGAACATCCGAAGACAATGTTCTCCAAAGATAAGGATATTATAC
CATTTATTGATAAATACTGGGAGTGCATGACAACCAGACAGAGACCTGGGAAAATGACTTGGCCAAATAACATTGTTAAAACAATGAGTA
AAGAAAGAGATGTATTCTTGGTAAAGGAACACCCAGATCCAGGCAGTAAAGATCCAGAAGAAGATTACCCCAAATTTGGACTTTTGGATC
AGGACCTTAGTAACATTGGTCCTGCTTATGACAACCAAAAACAGAGCAGTGCTGTGTCTACTAGTGGGAATTTAAATGGGGGAATTGCAG
CAGGAAGCAGCGGAAAAGGACGAGGAGCCAAGCGCAAACAGCAGGATGGAGGGACCACAGGGACCACCAAGAAGGCCCGGAGTGACCCTT
TGTTTTCTGCTCAGCGCCTTCCCCCTCATGGCTACCCATTGGAACACCCGTTTAACAAAGATGGCTATCGGTATATTCTAGCTGAGCCTG
ATCCGCACGCCCCTGACCCCGAGAAGCTGGAACTTGACTGCTGGGCAGGAAAACCTATTCCTGGAGACCTCTACAGAGCCTGCTTGTATG
AACGGGTTTTGTTAGCCCTACATGATCGAGATCCTCCTTTACATAGCACAGCTATATATGCTGATGAAGAAGAATTCTCCAAACATTGTG
GACTGTCTCTCTCTTCAACTCCTCCAGGAAAAGAAGCAAAAAGAAGTTCAGACACTTCTGGAAATGAAGCAAGTGAAATCGAATCTGTAA
AAATTAGTGCAAAAAAGCCAGGAAGAAAGCTCAGGCCCATTAGTGATGACTCTGAAAGCATTGAAGAAAGTGATACAAGGAGAAAAGTTA
AATCAGCAGAGAAAATAAGTACACAACGTCATGAGGTTATTCGAACCACAGCGTCTTCAGAACTTTCAGAGAAACCAGCTGAGTCTGTCA
CTTCTAAAAAGACAGGACCCCTTAGTGCCCAGCCCTCTGTTGAAAAAGAGAACTTGGCAATAGAAAGTCAATCGAAAACTCAGAAAAAAG
GGAAGATATCTCATGACAAAAGGAAGAAATCAAGAAGTAAAGCCATAGGCTCAGATACTTCTGACATTGTGCACATTTGGTGTCCAGAAG
GAATGAAAACCAGTGACATCAAGGAGTTGAATATTGTTTTGCCTGAATTTGAGAAAACCCACCTAGAGCATCAACAAAGAATAGAATCTA
AAGTTTGTAAGGCAGCCATCGCCACATTTTATGTTAATGTTAAAGAACAATTCATCAAAATGCTTAAAGAAAGCCAGATGTTGACAAATC
TGAAAAGGAAGAATGCTAAGATGATTTCAGATATCGAAAAGAAAAGGCAGCGTATGATTGAAGTCCAGGATGAACTGCTTCGGTTAGAGC
CACAGCTGAAACAACTACAAACAAAATATGATGAACTTAAAGAGAGAAAGTCTTCCCTTAGGAATGCAGCATATTTCTTATCTAATTTAA
AACAGCTTTATCAAGATTATTCAGATGTTCAAGCTCAAGAACCAAACGTAAAGGAAACGTATGATTCATCCAGCCTTCCAGCTCTGTTAT
TTAAAGCAAGAACACTTCTGGGAGCCGAAAGCCATCTGCGAAATATCAACCATCAGTTAGAGAAGCTCCTTGACCAGGGATGAGAAGAGC
AGTCTACTAAAATGTGCCTATAGGAAGACTAGTCTCATGCTGTTACCTTCTGAAACTGTACCTTTATAAATCAATTGTTTTGCAAAGAAG
TTATGGCCTACTTAGAATCTAAAATTTGTTATTCAAATTAAATGGCTGTGAACAATGTTAAATAGCATCAGTTTGTCCAATAGTTTTAAA
GGCCATAATCATCTTTTCTGGTTAATATCTTGAGTAATTTTAAAATGTTGACACCTTAATCGGTCCCAGGTATGAGCTATAATAAACTTG
TAAAATTAAGTTGATGTGAACATAATTTTGATTAATTAATAAGGCGATTTCTCCTGAATTTACACCAAAGCTAATTTTTAATGAAATTGG
TTTACAGAAGTAAAAAACAAAAATTGGAAAGCAAAGTAATAAAACTTAGTTTATATAAACAGGTTGAATGATATATTTATCAAATCTCAC
AGACATCAGGCAAATTATAGCCTGGTGACAAAAGTGTTCATAGTGAATTAGTTACTCTTGTAATACTTCTATAATTAGTTCATCAGGAAT
TTCATCCACTTCACTGTTATAACTGAGAAGACTGTTCTCTGCAGCTTCAGCTAATTCAGCATCTTCAGTAGCTTCTAAAAAATAAGCATC

>7132_7132_5_ASH2L-MLF1IP_ASH2L_chr8_37978667_ENST00000545394_MLF1IP_chr4_185646216_ENST00000281453_length(amino acids)=596AA_BP=241
MTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSK
ERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPL
FSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRDPPLHSTAIYADEEEFSKHCG
LSLSSTPPGKEAKRSSDTSGNEASEIESVKISAKKPGRKLRPISDDSESIEESDTRRKVKSAEKISTQRHEVIRTTASSELSEKPAESVT
SKKTGPLSAQPSVEKENLAIESQSKTQKKGKISHDKRKKSRSKAIGSDTSDIVHIWCPEGMKTSDIKELNIVLPEFEKTHLEHQQRIESK
VCKAAIATFYVNVKEQFIKMLKESQMLTNLKRKNAKMISDIEKKRQRMIEVQDELLRLEPQLKQLQTKYDELKERKSSLRNAAYFLSNLK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ASH2L-MLF1IP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneASH2Lchr8:37978667chr4:185646216ENST00000250635+1015316_628294.3333333333333502.0RBBP5
HgeneASH2Lchr8:37978667chr4:185646216ENST00000343823+1016316_628388.3333333333333629.0RBBP5
HgeneASH2Lchr8:37978667chr4:185646216ENST00000428278+1016316_628294.3333333333333535.0RBBP5
HgeneASH2Lchr8:37978667chr4:185646216ENST00000521652+1015316_628294.3333333333333502.0RBBP5


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ASH2L-MLF1IP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ASH2L-MLF1IP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC2239176Liver carcinoma1CTD_human