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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CERS5-INO80C (FusionGDB2 ID:HG91012TG125476)

Fusion Gene Summary for CERS5-INO80C

check button Fusion gene summary
Fusion gene informationFusion gene name: CERS5-INO80C
Fusion gene ID: hg91012tg125476
HgeneTgene
Gene symbol

CERS5

INO80C

Gene ID

91012

125476

Gene nameceramide synthase 5INO80 complex subunit C
SynonymsLASS5|Trh4C18orf37|IES6|hIes6
Cytomap('CERS5')('INO80C')

12q13.12

18q12.2

Type of geneprotein-codingprotein-coding
Descriptionceramide synthase 5LAG1 homolog, ceramide synthase 5LAG1 longevity assurance homolog 5TRAM homolog 4sphingosine N-acyltransferase CERS5INO80 complex subunit CIES6 homolog
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000317551, ENST00000422340, 
ENST00000547852, 
Fusion gene scores* DoF score8 X 6 X 7=3363 X 3 X 3=27
# samples 103
** MAII scorelog2(10/336*10)=-1.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CERS5 [Title/Abstract] AND INO80C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCERS5(50560883)-INO80C(33060527), # samples:1
Anticipated loss of major functional domain due to fusion event.CERS5-INO80C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CERS5-INO80C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCERS5

GO:0046513

ceramide biosynthetic process

16951403|29632068


check buttonFusion gene breakpoints across CERS5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across INO80C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A8NKCERS5chr12

50560883

-INO80Cchr18

33060527

-


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Fusion Gene ORF analysis for CERS5-INO80C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000317551ENST00000586489CERS5chr12

50560883

-INO80Cchr18

33060527

-
5CDS-intronENST00000317551ENST00000441607CERS5chr12

50560883

-INO80Cchr18

33060527

-
5CDS-intronENST00000317551ENST00000590757CERS5chr12

50560883

-INO80Cchr18

33060527

-
5UTR-3CDSENST00000422340ENST00000334598CERS5chr12

50560883

-INO80Cchr18

33060527

-
5UTR-3CDSENST00000422340ENST00000592173CERS5chr12

50560883

-INO80Cchr18

33060527

-
5UTR-3CDSENST00000547852ENST00000334598CERS5chr12

50560883

-INO80Cchr18

33060527

-
5UTR-3CDSENST00000547852ENST00000592173CERS5chr12

50560883

-INO80Cchr18

33060527

-
5UTR-5UTRENST00000422340ENST00000586489CERS5chr12

50560883

-INO80Cchr18

33060527

-
5UTR-5UTRENST00000547852ENST00000586489CERS5chr12

50560883

-INO80Cchr18

33060527

-
5UTR-intronENST00000422340ENST00000441607CERS5chr12

50560883

-INO80Cchr18

33060527

-
5UTR-intronENST00000422340ENST00000590757CERS5chr12

50560883

-INO80Cchr18

33060527

-
5UTR-intronENST00000547852ENST00000441607CERS5chr12

50560883

-INO80Cchr18

33060527

-
5UTR-intronENST00000547852ENST00000590757CERS5chr12

50560883

-INO80Cchr18

33060527

-
In-frameENST00000317551ENST00000334598CERS5chr12

50560883

-INO80Cchr18

33060527

-
In-frameENST00000317551ENST00000592173CERS5chr12

50560883

-INO80Cchr18

33060527

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000317551CERS5chr1250560883-ENST00000592173INO80Cchr1833060527-33523224730158
ENST00000317551CERS5chr1250560883-ENST00000334598INO80Cchr1833060527-10233224730158

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000317551ENST00000592173CERS5chr1250560883-INO80Cchr1833060527-0.0038776260.9961223
ENST00000317551ENST00000334598CERS5chr1250560883-INO80Cchr1833060527-0.0162971110.9837029

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Fusion Genomic Features for CERS5-INO80C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CERS5-INO80C


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:50560883/chr18:33060527)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCERS5chr12:50560883chr18:33060527ENST00000317551-1101_4665393.0Topological domainLumenal
HgeneCERS5chr12:50560883chr18:33060527ENST00000317551-11047_6765393.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCERS5chr12:50560883chr18:33060527ENST00000317551-110139_34065393.0DomainTLC
HgeneCERS5chr12:50560883chr18:33060527ENST00000317551-11075_13665393.0RegionHomeobox-like
HgeneCERS5chr12:50560883chr18:33060527ENST00000317551-110332_39265393.0Topological domainCytoplasmic
HgeneCERS5chr12:50560883chr18:33060527ENST00000317551-110148_16865393.0TransmembraneHelical
HgeneCERS5chr12:50560883chr18:33060527ENST00000317551-110183_20365393.0TransmembraneHelical
HgeneCERS5chr12:50560883chr18:33060527ENST00000317551-110214_23465393.0TransmembraneHelical
HgeneCERS5chr12:50560883chr18:33060527ENST00000317551-110272_29265393.0TransmembraneHelical
HgeneCERS5chr12:50560883chr18:33060527ENST00000317551-110311_33165393.0TransmembraneHelical


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Fusion Gene Sequence for CERS5-INO80C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>15986_15986_1_CERS5-INO80C_CERS5_chr12_50560883_ENST00000317551_INO80C_chr18_33060527_ENST00000334598_length(transcript)=1023nt_BP=322nt
CCAGAAGGGGCCGGAAGGGGGTGGCCGCCGGCCGGGCCCCGCCCTGGGGCCGCCTCCCCGCGGGTTCCGTTGGCTGTGGCGGCAGCTGAC
GCTTGTGGCGGCGGTGGCTTCGGGGTGGGCGTAAGATGGCGACAGCAGCGCAGGGACCCCTAAGCTTGCTGTGGGGCTGGCTGTGGAGCG
AGCGCTTCTGGCTACCCGAGAACGTGAGCTGGGCTGATCTGGAGGGGCCGGCCGACGGCTACGGTTACCCCCGCGGCCGGCACATCCTCT
CGGTGTTCCCGCTGGCGGCGGGCATCTTCTTCGTGAGGCTGCTCTTCGAGCGGGTATCAGCATGGAAGCCATGAGTGAGAATAAAATGGT
GCCCTCTGAGTTTAGCACAGGACCTGTGGAAAAAGCTGCCAAACCTTTGCCATTTAAGGATCCCAACTTTGTGCACTCTGGCCACGGTGG
CGCAGTAGCTGGCAAGAAGAACAGAACCTGGAAGAACCTGAAACAAATCCTCGCTTCTGAAAGGGCATTGCCGTGGCAACTGAACGATCC
TAACTACTTCAGTATTGATGCTCCTCCATCCTTTAAGCCAGCTAAGAAGTATTCTGATGTTTCAGGTCTGCTTGCCAACTACACAGACCC
CCAGAGCAAACTGCGGTTCAGCACCATTGAAGAGTTTTCCTACATTCGGAGGCTGCCCTCTGACGTCGTCACCGGCTACCTGGCCCTGAG
GAAGGCCACGAGCATCGTTCCCTGAGCCCCAGAAAGGGAGATGAAGTGGAAAGCTGTTTCAAAAACAGACTCTGGACTCATGATTTTGTT
TCACGGAAACAAACTCGTTCTGCTGTCAATCTGAAAATGCCAGTGCTGTGCCTTGGAAAGAATGTTTGGCTTTAATTTAAGGGTTTTTTT
TTTTTTTAGTGTGTGTTTTCCCTCCAAGTGTGATATTTCCTGCTGAATTAAATTATACTTCAGTTGTTGCCTCAAGTAAAGGTGTTTGAC

>15986_15986_1_CERS5-INO80C_CERS5_chr12_50560883_ENST00000317551_INO80C_chr18_33060527_ENST00000334598_length(amino acids)=158AA_BP=1
MFFLPATAPPWPECTKLGSLNGKGLAAFSTGPVLNSEGTILFSLMASMLIPARRAASRRRCPPPAGTPRGCAGRGGNRSRRPAPPDQPSS

--------------------------------------------------------------
>15986_15986_2_CERS5-INO80C_CERS5_chr12_50560883_ENST00000317551_INO80C_chr18_33060527_ENST00000592173_length(transcript)=3352nt_BP=322nt
CCAGAAGGGGCCGGAAGGGGGTGGCCGCCGGCCGGGCCCCGCCCTGGGGCCGCCTCCCCGCGGGTTCCGTTGGCTGTGGCGGCAGCTGAC
GCTTGTGGCGGCGGTGGCTTCGGGGTGGGCGTAAGATGGCGACAGCAGCGCAGGGACCCCTAAGCTTGCTGTGGGGCTGGCTGTGGAGCG
AGCGCTTCTGGCTACCCGAGAACGTGAGCTGGGCTGATCTGGAGGGGCCGGCCGACGGCTACGGTTACCCCCGCGGCCGGCACATCCTCT
CGGTGTTCCCGCTGGCGGCGGGCATCTTCTTCGTGAGGCTGCTCTTCGAGCGGGTATCAGCATGGAAGCCATGAGTGAGAATAAAATGGT
GCCCTCTGAGTTTAGCACAGGACCTGTGGAAAAAGCTGCCAAACCTTTGCCATTTAAGGATCCCAACTTTGTGCACTCTGGCCACGGTGG
CGCAGTAGCTGGCAAGAAGAACAGAACCTGGAAGAACCTGAAACAAATCCTCGCTTCTGAAAGGGCATTGCCGTGGCAACTGAACGATCC
TAACTACTTCAGTATTGATGCTCCTCCATCCTTTAAGCCAGCTAAGAAGTATTCTGATGTTTCAGGTCTGCTTGAACCACCAAACTGTTT
TCCACAGAGGCTGCATCAATTGACATTCCCACTAGCAATGGATGAGGGTTCCAATTTTTCCAGATGCTCACCAACACTTGTTAATTTTGG
TTTTGTTTTCATTATGGCCATTCTGGTGGGTGTAAAGTAGCATCTCATTGTGGCTTGACTGAATTTCTCTAATGAGTAATGATGTTGAGC
ATTTTTCATGTGCTTATTGGCTATTTGTATATCTTTGTTGGAGAAATATCTGTTCAAGTTCTTTGGCCATTTTAAAATTGGGTTGTCTTT
TTGTTGTTGAATTGTAAAGTTCTTTAGATATTCTGAATACTAGATCCTTATTAAATATATGATTTGAAAATATTTTTCCCATTTTGAATG
TTGTCTTTTCATTTTTTGGATAGTGTCTTTTGGTGCACCAAACTTCAAAAATTTTTTCGAAGTCCAGTTTATCAATTTTTTATTTTGTTG
CCTGTGCTTTTGGTGTCATATCCAATAAGTCATTGCCAAATCCAATGTCACAAATATATTTTTGCTGCTTTCTTGTAAGAGTTATACAGT
TTTAGCTCATATGTTTAGGTCTTTGATGCATTTTGAGTTAATTTTTGTATGTAGTGTAGGATAAGGGTCTAACTTCATTCCTTTGCATGT
AAATATTCCATTTTTCTGGCACCATTTGTTGTAGGAACTGTCATTTCCCCATTAAATGATTTGGCATCCTTGTCAGAAATCAATTGTCCA
TACATGTGAGGGTTTATTTCTGGGCTCCCAATTCTATTCCATTGGTCTATACATCTGTTCCCATGCCAGTACCACACTGTTTGATTAATG
TCGATTTTTAGTAAGTTTTGAAATCAGGAAGTGTGAATCCTCCAACTTTGTTCTTTTCAAGATCATTTTGGTTATATGGGTTACCTTAAG
ATTCCATTTGAATTTTCGGATGGGTTTTTCTATTTTTGTAAAAAATATCATTGGGATTTTGATAGGAATTGCACTGAATCTGTAGATCGC
TTTGGGTAGTACTATCATATTAACAATATTAAGTCTTCCAAGCCATAAACATGGACTGTCTTTCCATTTATTTAGATTTTCTTTAATTTC
TTTCAGCAATGTTTTGCAGTATTCAGTGTACAAGTCTTTTGCCTCCTTTGTTAAATTTATTCCTAAGGATGCTATTCTTTCTGATGCTAG
TAAAATAGTTTTCCTAATTTCATTTTCAGATCATGCATAACCACCACCATAAACATGATTCCAACACCCCAGAGTATTCCCTCAGTCTGA
CCTTTTGTAAAGTGGTGCTTTTTAAAATTTAATTTTCCAATTGCTTGTTGCTAGTGTATAGAAATACGACTGATACTTTTATATTGGCCT
TGTATCCTGAGACCCTGTAAATTCACTTATTAGTTCTAGACAGTTTTAATTCTTTCTTTCCAATCTTTATGCCTATTATTTCTGTTTTGT
TTTGTTTTTTAAACAGGGTTTGGCTCTGTCACCCAGGCTGGAGTGCAGTGGCTTGATTCCAACTCACTGCACCCTCGACCTCCTGGGCTC
AAGTCATCCTCCCACCTCAGCCTTCCAAGTAGCTGGGACTACAAGCATGAGCCACCACACCCAGCTAATTTTTTTTCTTTTCTTTTTCTT
TTTTTTTTTTTTTGGAGGGTGCAGGGAGCAGAGTCTTGCTCTGTTGCCCAGGCTGGTCTCAAATTCCTGAGCTCAAGTAATTCATACACC
TTGGCCTCCCAAAGTGCTAGGATTACAGGCATGAGTCACCTTGCCTGACTATTACTTCTTTTTTTGAGACAGTCTTGCTCTGTTGCCAGG
CTGGAGTGCAGTGGCATGATCTCGGCTCACTGCAACCTCCGCCTCATGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAGGTAGCTGGG
ACTACAGATGCATGCCACCACACCAAGCTAATTTTTAGATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGATGGTCTCGATCTC
TTGACCTCATGATCCACCTGCCTCAGCCTCCCAACATGCTGGGATTACAGGCGTGAGCCACTGCACCCGGCCTATTATTCCTTTTTTTGC
CCTATTGTCCCAGTGGATAGTGATGTCCAGTAGAGCGTTGAATCAAAGTGGTAAAATTGTGCGTCCTTGCCTTGTTCTCCACGTTAAGGT
GAAATTTTGAAGATTTCATTATTACATATGATGTAAGCTGTAGGTTTTTATTTATTTATTTATTTAGAGACAGGGTCTTGCTCTGTCACC
CAGGCTGGAGTACAGTGGCATGATCCACTGTAGCCTTGACCTCCCAGTCTCAAGCAGTCCTCCCACCTCAGCCTCCCAAATAGCTGAGAC
CACAGGCACATGCCACCATACCCTGCTAATTTTTTATTTTTTGTAGACATGGGGTCTTACTATCTTGACCAGGCTGGTCTCAAACTCATG
GGCTCAAATCATCCTCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCACCTGGCCTAACTGTGGGCTTTTTTTG
AAATGTCTTTTTCAGGTTGAGGAAGGTCCCTTCTATTCCTAGTGTACTGAGAGTTTGTATCATGAAAAGGTATTGAATTTTGTCAAATGT
TGTTCCTGTGTCTATTGAGATGGCTGTATGGGTTTTCTCTTTTTTCTGATAATGTGATGAATTATATGGATTTATTAATATTGAAATAAT

>15986_15986_2_CERS5-INO80C_CERS5_chr12_50560883_ENST00000317551_INO80C_chr18_33060527_ENST00000592173_length(amino acids)=158AA_BP=1
MFFLPATAPPWPECTKLGSLNGKGLAAFSTGPVLNSEGTILFSLMASMLIPARRAASRRRCPPPAGTPRGCAGRGGNRSRRPAPPDQPSS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CERS5-INO80C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CERS5-INO80C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CERS5-INO80C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource