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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:R3HDM4-JAK3 (FusionGDB2 ID:HG91300TG3718)

Fusion Gene Summary for R3HDM4-JAK3

check button Fusion gene summary
Fusion gene informationFusion gene name: R3HDM4-JAK3
Fusion gene ID: hg91300tg3718
HgeneTgene
Gene symbol

R3HDM4

JAK3

Gene ID

91300

3718

Gene nameR3H domain containing 4Janus kinase 3
SynonymsC19orf22JAK-3|JAK3_HUMAN|JAKL|L-JAK|LJAK
Cytomap('C19orf22','R3HDM4')('JAK3','JAK3')

19p13.3

19p13.11

Type of geneprotein-codingprotein-coding
DescriptionR3H domain-containing protein 4R3H domain-containing protein C19orf22tyrosine-protein kinase JAK3Janus kinase 3 (a protein tyrosine kinase, leukocyte)leukocyte Janus kinase
Modification date2020031320200315
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000361574, ENST00000587975, 
Fusion gene scores* DoF score4 X 3 X 5=601 X 2 X 1=2
# samples 72
** MAII scorelog2(7/60*10)=0.222392421336448
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/2*10)=3.32192809488736
Context

PubMed: R3HDM4 [Title/Abstract] AND JAK3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointR3HDM4(913087)-JAK3(17953981), # samples:2
C19orf22(913087)-JAK3(17953981), # samples:1
Anticipated loss of major functional domain due to fusion event.R3HDM4-JAK3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
R3HDM4-JAK3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
R3HDM4-JAK3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
R3HDM4-JAK3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
R3HDM4-JAK3 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
R3HDM4-JAK3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
R3HDM4-JAK3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
R3HDM4-JAK3 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneJAK3

GO:0035771

interleukin-4-mediated signaling pathway

7538655

TgeneJAK3

GO:0070670

response to interleukin-4

7538655|7594533


check buttonFusion gene breakpoints across R3HDM4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across JAK3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A891-01AC19orf22chr19

913087

-JAK3chr19

17953981

-
ChimerDB4ESCATCGA-L5-A891-01AR3HDM4chr19

913087

-JAK3chr19

17953981

-
ChimerDB4ESCATCGA-L5-A891R3HDM4chr19

913086

-JAK3chr19

17953981

-
ChimerDB4ESCATCGA-L5-A891R3HDM4chr19

913087

-JAK3chr19

17953981

-
ChimerDB4ESCATCGA-L5-A891R3HDM4chr19

913087

-JAK3chr19

17954266

-


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Fusion Gene ORF analysis for R3HDM4-JAK3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000361574ENST00000526008R3HDM4chr19

913087

-JAK3chr19

17953981

-
5CDS-5UTRENST00000361574ENST00000526008R3HDM4chr19

913086

-JAK3chr19

17953981

-
5CDS-5UTRENST00000361574ENST00000526008R3HDM4chr19

913087

-JAK3chr19

17954266

-
5CDS-5UTRENST00000361574ENST00000527670R3HDM4chr19

913087

-JAK3chr19

17953981

-
5CDS-5UTRENST00000361574ENST00000527670R3HDM4chr19

913086

-JAK3chr19

17953981

-
5CDS-5UTRENST00000361574ENST00000527670R3HDM4chr19

913087

-JAK3chr19

17954266

-
5CDS-5UTRENST00000587975ENST00000526008R3HDM4chr19

913087

-JAK3chr19

17953981

-
5CDS-5UTRENST00000587975ENST00000526008R3HDM4chr19

913086

-JAK3chr19

17953981

-
5CDS-5UTRENST00000587975ENST00000526008R3HDM4chr19

913087

-JAK3chr19

17954266

-
5CDS-5UTRENST00000587975ENST00000527670R3HDM4chr19

913087

-JAK3chr19

17953981

-
5CDS-5UTRENST00000587975ENST00000527670R3HDM4chr19

913086

-JAK3chr19

17953981

-
5CDS-5UTRENST00000587975ENST00000527670R3HDM4chr19

913087

-JAK3chr19

17954266

-
Frame-shiftENST00000361574ENST00000458235R3HDM4chr19

913087

-JAK3chr19

17954266

-
Frame-shiftENST00000361574ENST00000534444R3HDM4chr19

913087

-JAK3chr19

17954266

-
Frame-shiftENST00000587975ENST00000458235R3HDM4chr19

913087

-JAK3chr19

17954266

-
Frame-shiftENST00000587975ENST00000534444R3HDM4chr19

913087

-JAK3chr19

17954266

-
In-frameENST00000361574ENST00000458235R3HDM4chr19

913087

-JAK3chr19

17953981

-
In-frameENST00000361574ENST00000458235R3HDM4chr19

913086

-JAK3chr19

17953981

-
In-frameENST00000361574ENST00000534444R3HDM4chr19

913087

-JAK3chr19

17953981

-
In-frameENST00000361574ENST00000534444R3HDM4chr19

913086

-JAK3chr19

17953981

-
In-frameENST00000587975ENST00000458235R3HDM4chr19

913087

-JAK3chr19

17953981

-
In-frameENST00000587975ENST00000458235R3HDM4chr19

913086

-JAK3chr19

17953981

-
In-frameENST00000587975ENST00000534444R3HDM4chr19

913087

-JAK3chr19

17953981

-
In-frameENST00000587975ENST00000534444R3HDM4chr19

913086

-JAK3chr19

17953981

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000361574R3HDM4chr19913087-ENST00000458235JAK3chr1917953981-50571451573099980
ENST00000361574R3HDM4chr19913087-ENST00000534444JAK3chr1917953981-32521451573009950
ENST00000587975R3HDM4chr19913087-ENST00000458235JAK3chr1917953981-50661541663108980
ENST00000587975R3HDM4chr19913087-ENST00000534444JAK3chr1917953981-32611541663018950
ENST00000361574R3HDM4chr19913086-ENST00000458235JAK3chr1917953981-50571451573099980
ENST00000361574R3HDM4chr19913086-ENST00000534444JAK3chr1917953981-32521451573009950
ENST00000587975R3HDM4chr19913086-ENST00000458235JAK3chr1917953981-50661541663108980
ENST00000587975R3HDM4chr19913086-ENST00000534444JAK3chr1917953981-32611541663018950

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361574ENST00000458235R3HDM4chr19913087-JAK3chr1917953981-0.0042685560.9957314
ENST00000361574ENST00000534444R3HDM4chr19913087-JAK3chr1917953981-0.0107723650.98922765
ENST00000587975ENST00000458235R3HDM4chr19913087-JAK3chr1917953981-0.0042700680.99572986
ENST00000587975ENST00000534444R3HDM4chr19913087-JAK3chr1917953981-0.0107649290.9892351
ENST00000361574ENST00000458235R3HDM4chr19913086-JAK3chr1917953981-0.0042685560.9957314
ENST00000361574ENST00000534444R3HDM4chr19913086-JAK3chr1917953981-0.0107723650.98922765
ENST00000587975ENST00000458235R3HDM4chr19913086-JAK3chr1917953981-0.0042700680.99572986
ENST00000587975ENST00000534444R3HDM4chr19913086-JAK3chr1917953981-0.0107649290.9892351

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Fusion Genomic Features for R3HDM4-JAK3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for R3HDM4-JAK3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:913087/chr19:17953981)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneJAK3chr19:913086chr19:17953981ENST00000458235324375_4751401125.0DomainNote=SH2%3B atypical
TgeneJAK3chr19:913086chr19:17953981ENST00000458235324521_7811401125.0DomainProtein kinase 1
TgeneJAK3chr19:913086chr19:17953981ENST00000458235324822_11111401125.0DomainProtein kinase 2
TgeneJAK3chr19:913086chr19:17953981ENST00000527670223375_4751401125.0DomainNote=SH2%3B atypical
TgeneJAK3chr19:913086chr19:17953981ENST00000527670223521_7811401125.0DomainProtein kinase 1
TgeneJAK3chr19:913086chr19:17953981ENST00000527670223822_11111401125.0DomainProtein kinase 2
TgeneJAK3chr19:913086chr19:17953981ENST00000534444323375_4751401095.0DomainNote=SH2%3B atypical
TgeneJAK3chr19:913086chr19:17953981ENST00000534444323521_7811401095.0DomainProtein kinase 1
TgeneJAK3chr19:913086chr19:17953981ENST00000534444323822_11111401095.0DomainProtein kinase 2
TgeneJAK3chr19:913087chr19:17953981ENST00000458235324375_4751401125.0DomainNote=SH2%3B atypical
TgeneJAK3chr19:913087chr19:17953981ENST00000458235324521_7811401125.0DomainProtein kinase 1
TgeneJAK3chr19:913087chr19:17953981ENST00000458235324822_11111401125.0DomainProtein kinase 2
TgeneJAK3chr19:913087chr19:17953981ENST00000527670223375_4751401125.0DomainNote=SH2%3B atypical
TgeneJAK3chr19:913087chr19:17953981ENST00000527670223521_7811401125.0DomainProtein kinase 1
TgeneJAK3chr19:913087chr19:17953981ENST00000527670223822_11111401125.0DomainProtein kinase 2
TgeneJAK3chr19:913087chr19:17953981ENST00000534444323375_4751401095.0DomainNote=SH2%3B atypical
TgeneJAK3chr19:913087chr19:17953981ENST00000534444323521_7811401095.0DomainProtein kinase 1
TgeneJAK3chr19:913087chr19:17953981ENST00000534444323822_11111401095.0DomainProtein kinase 2
TgeneJAK3chr19:913086chr19:17953981ENST00000458235324828_8361401125.0Nucleotide bindingATP
TgeneJAK3chr19:913086chr19:17953981ENST00000527670223828_8361401125.0Nucleotide bindingATP
TgeneJAK3chr19:913086chr19:17953981ENST00000534444323828_8361401095.0Nucleotide bindingATP
TgeneJAK3chr19:913087chr19:17953981ENST00000458235324828_8361401125.0Nucleotide bindingATP
TgeneJAK3chr19:913087chr19:17953981ENST00000527670223828_8361401125.0Nucleotide bindingATP
TgeneJAK3chr19:913087chr19:17953981ENST00000534444323828_8361401095.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneR3HDM4chr19:913086chr19:17953981ENST00000361574-18132_18423269.0Compositional biasNote=Arg-rich
HgeneR3HDM4chr19:913087chr19:17953981ENST00000361574-18132_18423269.0Compositional biasNote=Arg-rich
HgeneR3HDM4chr19:913086chr19:17953981ENST00000361574-18187_25023269.0DomainR3H
HgeneR3HDM4chr19:913087chr19:17953981ENST00000361574-18187_25023269.0DomainR3H
TgeneJAK3chr19:913086chr19:17953981ENST0000045823532424_3561401125.0DomainFERM
TgeneJAK3chr19:913086chr19:17953981ENST0000052767022324_3561401125.0DomainFERM
TgeneJAK3chr19:913086chr19:17953981ENST0000053444432324_3561401095.0DomainFERM
TgeneJAK3chr19:913087chr19:17953981ENST0000045823532424_3561401125.0DomainFERM
TgeneJAK3chr19:913087chr19:17953981ENST0000052767022324_3561401125.0DomainFERM
TgeneJAK3chr19:913087chr19:17953981ENST0000053444432324_3561401095.0DomainFERM


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Fusion Gene Sequence for R3HDM4-JAK3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>71104_71104_1_R3HDM4-JAK3_R3HDM4_chr19_913086_ENST00000361574_JAK3_chr19_17953981_ENST00000458235_length(transcript)=5057nt_BP=145nt
CGGGCGCCCGTCACTTCCTGCCCGGCCCGGTGAAGGCCCTGCCGGGCGGCGGCGGCGGCGACAGCGTGCGAGCCATGGTCGCGCTGGAGA
ACCCCGAGTGCGGCCCGGAGGCGGCGGAGGGCACCCCGGGCGGGCGGCGGCTGCTCACCGCAGTGACCTGGTGAGTGGGCGCCTCCCCGT
GGGCCTCAGTCTCAAGGAGCAGGGTGAGTGTCTCAGCCTGGCCGTGTTGGACCTGGCCCGGATGGCGCGAGAGCAGGCCCAGCGGCCGGG
AGAGCTGCTGAAGACTGTCAGCTACAAGGCCTGCCTACCCCCAAGCCTGCGCGACCTGATCCAGGGCCTGAGCTTCGTGACGCGGAGGCG
TATTCGGAGGACGGTGCGCAGAGCCCTGCGCCGCGTGGCCGCCTGCCAGGCAGACCGGCACTCGCTCATGGCCAAGTACATCATGGACCT
GGAGCGGCTGGATCCAGCCGGGGCCGCCGAGACCTTCCACGTGGGCCTCCCTGGGGCCCTTGGTGGCCACGACGGGCTGGGGCTGCTCCG
CGTGGCTGGTGACGGCGGCATCGCCTGGACCCAGGGAGAACAGGAGGTCCTCCAGCCCTTCTGCGACTTTCCAGAAATCGTAGACATTAG
CATCAAGCAGGCCCCGCGCGTTGGCCCGGCCGGAGAGCACCGCCTGGTCACTGTTACCAGGACAGACAACCAGATTTTAGAGGCCGAGTT
CCCAGGGCTGCCCGAGGCTCTGTCGTTCGTGGCGCTCGTGGACGGCTACTTCCGGCTGACCACGGACTCCCAGCACTTCTTCTGCAAGGA
GGTGGCACCGCCGAGGCTGCTGGAGGAAGTGGCCGAGCAGTGCCACGGCCCCATCACTCTGGACTTTGCCATCAACAAGCTCAAGACTGG
GGGCTCACGTCCTGGCTCCTATGTTCTCCGCCGCAGCCCCCAGGACTTTGACAGCTTCCTCCTCACTGTCTGTGTCCAGAACCCCCTTGG
TCCTGATTATAAGGGCTGCCTCATCCGGCGCAGCCCCACAGGAACCTTCCTTCTGGTTGGCCTCAGCCGACCCCACAGCAGTCTTCGAGA
GCTCCTGGCAACCTGCTGGGATGGGGGGCTGCACGTAGATGGGGTGGCAGTGACCCTCACTTCCTGCTGTATCCCCAGACCCAAAGAAAA
GTCCAACCTGATCGTGGTCCAGAGAGGTCACAGCCCACCCACATCATCCTTGGTTCAGCCCCAATCCCAATACCAGCTGAGTCAGATGAC
ATTTCACAAGATCCCTGCTGACAGCCTGGAGTGGCATGAGAACCTGGGCCATGGGTCCTTCACCAAGATTTACCGGGGCTGTCGCCATGA
GGTGGTGGATGGGGAGGCCCGAAAGACAGAGGTGCTGCTGAAGGTCATGGATGCCAAGCACAAGAACTGCATGGAGTCATTCCTGGAAGC
AGCGAGCTTGATGAGCCAAGTGTCGTACCGGCATCTCGTGCTGCTCCACGGCGTGTGCATGGCTGGAGACAGCACCATGGTGCAGGAATT
TGTACACCTGGGGGCCATAGACATGTATCTGCGAAAACGTGGCCACCTGGTGCCAGCCAGCTGGAAGCTGCAGGTGGTCAAACAGCTGGC
CTACGCCCTCAACTATCTGGAGGACAAAGGCCTGCCCCATGGCAATGTCTCTGCCCGGAAGGTGCTCCTGGCTCGGGAGGGGGCTGATGG
GAGCCCGCCCTTCATCAAGCTGAGTGACCCTGGGGTCAGCCCCGCTGTGTTAAGCCTGGAGATGCTCACCGACAGGATCCCCTGGGTGGC
CCCCGAGTGTCTCCGGGAGGCGCAGACACTTAGCTTGGAAGCTGACAAGTGGGGCTTCGGCGCCACGGTCTGGGAAGTGTTTAGTGGCGT
CACCATGCCCATCAGTGCCCTGGATCCTGCTAAGAAACTCCAATTTTATGAGGACCGGCAGCAGCTGCCGGCCCCCAAGTGGACAGAGCT
GGCCCTGCTGATTCAACAGTGCATGGCCTATGAGCCGGTCCAGAGGCCCTCCTTCCGAGCCGTCATTCGTGACCTCAATAGCCTCATCTC
TTCAGACTATGAGCTCCTCTCAGACCCCACACCTGGTGCCCTGGCACCTCGTGATGGGCTGTGGAATGGTGCCCAGCTCTATGCCTGCCA
AGACCCCACGATCTTCGAGGAGAGACACCTCAAGTACATCTCACAGCTGGGCAAGGGCAACTTTGGCAGCGTGGAGCTGTGCCGCTATGA
CCCGCTAGGCGACAATACAGGTGCCCTGGTGGCCGTGAAACAGCTGCAGCACAGCGGGCCAGACCAGCAGAGGGACTTTCAGCGGGAGAT
TCAGATCCTCAAAGCACTGCACAGTGATTTCATTGTCAAGTATCGTGGTGTCAGCTATGGCCCGGGCCGCCAGAGCCTGCGGCTGGTCAT
GGAGTACCTGCCCAGCGGCTGCTTGCGCGACTTCCTGCAGCGGCACCGCGCGCGCCTCGATGCCAGCCGCCTCCTTCTCTATTCCTCGCA
GATCTGCAAGGGCATGGAGTACCTGGGCTCCCGCCGCTGCGTGCACCGCGACCTGGCCGCCCGAAACATCCTCGTGGAGAGCGAGGCACA
CGTCAAGATCGCTGACTTCGGCCTAGCTAAGCTGCTGCCGCTTGACAAAGACTACTACGTGGTCCGCGAGCCAGGCCAGAGCCCCATTTT
CTGGTATGCCCCCGAATCCCTCTCGGACAACATCTTCTCTCGCCAGTCAGACGTCTGGAGCTTCGGGGTCGTCCTGTACGAGCTCTTCAC
CTACTGCGACAAAAGCTGCAGCCCCTCGGCCGAGTTCCTGCGGATGATGGGATGTGAGCGGGATGTCCCCGCCCTCTGCCGCCTCTTGGA
ACTGCTGGAGGAGGGCCAGAGGCTGCCGGCGCCTCCTGCCTGCCCTGCTGAGGTTCACGAGCTCATGAAGCTGTGCTGGGCCCCTAGCCC
ACAGGACCGGCCATCATTCAGCGCCCTGGGCCCCCAGCTGGACATGCTGTGGAGCGGAAGCCGGGGGTGTGAGACTCATGCCTTCACTGC
TCACCCAGAGGGCAAACACCACTCCCTGTCCTTTTCATAGCTCCTGCCCGCAGACCTCTGGATTAGGTCTCTGTTGACTGGCTGTGTGAC
CTTAGGCCCGGAGCTGCCCCTCTCTGGGCCTCAGAGGCCTTATGAGGGTCCTCTACTTCAGGAACACCCCCATGACATTGCATTTGGGGG
GGCTCCCGTGGCCTGTAGAATAGCCTGTGGCCTTTGCAATTTGTTAAGGTTCAAGACAGATGGGCATATGTGTCAGTGGGGCTCTCTGAG
TCCTGGCCCAAAGAAGCAAGGAACCAAATTTAAGACTCTCGCATCTTCCCAACCCCTTAAGCCCTGGCCCCCTGAGTTTCCTTTTCTGTC
TCTCTCTTTTTATTTTTTTTATTTTTATTTTTATTTTTGAGACAGAGCCTCGCTCTGTTACCCAGGGTGGAGTGCAGTGGTGCGATCTCG
GCTCAGTGCAACCTCTGCTTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGTGTGCACCACCACACC
CGGCTAATTTTTTTTATTTTTAATAGAGATGAGGTTTCACCATGATGGCCAGGCTGATCTCGAACTCCTAACCTCAAGTGATCCTCCCAC
CTCAGCCTCCCAAAGTGTTGGAATAATAGGCATGAGCCACTGCACCCAGGCTTTTTTTTTTTTAAATTTATTATTATTATTTTTAAGAGA
CAGGATCTTGCTACGTTGCCCAGGCTGGTCTTGAACTCCTGGGCTACAGTGATCCTCCTGCCTTATCCTCCTAAATAGCTGGGACTACAG
CACCTAGTTTTGAGTTTCCTGTCTTATTTCCAATGGGGACATTCATGTAGCTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCT
GTCGCCCAGGCTGGAGTACAGTGGCGCAATCTAGGCTCACTGCAAGCTCCGCCTCCTGGGTTCACACCATTCTCTCGCCTCAGCCTCCCA
AGTAGCTGGGACTACAGGCGCCCGCCACCACACCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCTTGTTAGCCAGGATG
GTTTCCATCTCCTGACCTCGTGATCTGCCCGTCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCTCATGT
AGCTTTAAATGTATGATCTGACTTCTGCTCCCCGATCTCTGTTTCTCTGGAGGAAGCCAAGGACAAGAGCAGTTGCTGTGGCTGGGACTC
TGCCTTTTAGGGGAGCCCGTGTATCTCTTTGGGATCCTGAAAGGGGGCAGGAAAGGCTGGGGTCCCAGTCCACCCTAATGGTATCTGAGT
GTCCTAGGGCTTCAGTTTTCCCACCTGTCCAATGGGACCCTTTCTGTCCTCACCCTACAAGGGGCACAAAGGGATGACACCAAACCTGGC
AGGAACTTTTCACGCAATCAAGGGAAGGAAAGGCATTCCTGGCAGAGGGAACAGCATGCCAAGCGTGAGAAGGCTCAGAGTAAGGAGGTT
AAGAGCCCAAGTATTGGAGCCTACAGTTTTGCCCCTTCCATGCAGTGTGACAGTGGGCAAGTTCCTTTCCCTCTCTGGGTCTCAGTTCTG
TCCCCTGCAAAATGGTCAGAGCTTACCCCTTGGCTGTGCAGGGTCAACTTTCTGACTGGTGAGAGGGATTCTCATGCAGGTTAAGCTTCT
GCTGCTCCTCCTCACCTGCAAAGCTTTTCTGCCACTTTTGCCTCCTTGGAAAACTCTTATCCATCTCTCAAAACTCCAGCTACCACATCC
TTGCAGCCTTCCCTCATATACCCCCACTACTACTGTAGCCCTGTCCTTCCCTCCAGCCCCACTCTGGCCCTGGGGCTGGGGAAGTGTCTG
TGTCCAGCTGTCTCCCCTGACCTCAGGGTTCCTTGGGGGCTGGGCTGAGGCCTCAGTACAGAGGGGGCTCTGGAAATGTTTGTTGACTGA

>71104_71104_1_R3HDM4-JAK3_R3HDM4_chr19_913086_ENST00000361574_JAK3_chr19_17953981_ENST00000458235_length(amino acids)=980AA_BP=
MVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSL
MAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTD
NQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLT
VCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQS
QYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAG
DSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEML
TDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVI
RDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQ
QRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARN
ILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDV

--------------------------------------------------------------
>71104_71104_2_R3HDM4-JAK3_R3HDM4_chr19_913086_ENST00000361574_JAK3_chr19_17953981_ENST00000534444_length(transcript)=3252nt_BP=145nt
CGGGCGCCCGTCACTTCCTGCCCGGCCCGGTGAAGGCCCTGCCGGGCGGCGGCGGCGGCGACAGCGTGCGAGCCATGGTCGCGCTGGAGA
ACCCCGAGTGCGGCCCGGAGGCGGCGGAGGGCACCCCGGGCGGGCGGCGGCTGCTCACCGCAGTGACCTGGTGAGTGGGCGCCTCCCCGT
GGGCCTCAGTCTCAAGGAGCAGGGTGAGTGTCTCAGCCTGGCCGTGTTGGACCTGGCCCGGATGGCGCGAGAGCAGGCCCAGCGGCCGGG
AGAGCTGCTGAAGACTGTCAGCTACAAGGCCTGCCTACCCCCAAGCCTGCGCGACCTGATCCAGGGCCTGAGCTTCGTGACGCGGAGGCG
TATTCGGAGGACGGTGCGCAGAGCCCTGCGCCGCGTGGCCGCCTGCCAGGCAGACCGGCACTCGCTCATGGCCAAGTACATCATGGACCT
GGAGCGGCTGGATCCAGCCGGGGCCGCCGAGACCTTCCACGTGGGCCTCCCTGGGGCCCTTGGTGGCCACGACGGGCTGGGGCTGCTCCG
CGTGGCTGGTGACGGCGGCATCGCCTGGACCCAGGGAGAACAGGAGGTCCTCCAGCCCTTCTGCGACTTTCCAGAAATCGTAGACATTAG
CATCAAGCAGGCCCCGCGCGTTGGCCCGGCCGGAGAGCACCGCCTGGTCACTGTTACCAGGACAGACAACCAGATTTTAGAGGCCGAGTT
CCCAGGGCTGCCCGAGGCTCTGTCGTTCGTGGCGCTCGTGGACGGCTACTTCCGGCTGACCACGGACTCCCAGCACTTCTTCTGCAAGGA
GGTGGCACCGCCGAGGCTGCTGGAGGAAGTGGCCGAGCAGTGCCACGGCCCCATCACTCTGGACTTTGCCATCAACAAGCTCAAGACTGG
GGGCTCACGTCCTGGCTCCTATGTTCTCCGCCGCAGCCCCCAGGACTTTGACAGCTTCCTCCTCACTGTCTGTGTCCAGAACCCCCTTGG
TCCTGATTATAAGGGCTGCCTCATCCGGCGCAGCCCCACAGGAACCTTCCTTCTGGTTGGCCTCAGCCGACCCCACAGCAGTCTTCGAGA
GCTCCTGGCAACCTGCTGGGATGGGGGGCTGCACGTAGATGGGGTGGCAGTGACCCTCACTTCCTGCTGTATCCCCAGACCCAAAGAAAA
GTCCAACCTGATCGTGGTCCAGAGAGGTCACAGCCCACCCACATCATCCTTGGTTCAGCCCCAATCCCAATACCAGCTGAGTCAGATGAC
ATTTCACAAGATCCCTGCTGACAGCCTGGAGTGGCATGAGAACCTGGGCCATGGGTCCTTCACCAAGATTTACCGGGGCTGTCGCCATGA
GGTGGTGGATGGGGAGGCCCGAAAGACAGAGGTGCTGCTGAAGGTCATGGATGCCAAGCACAAGAACTGCATGGAGTCATTCCTGGAAGC
AGCGAGCTTGATGAGCCAAGTGTCGTACCGGCATCTCGTGCTGCTCCACGGCGTGTGCATGGCTGGAGACAGCACCATGGTGCAGGAATT
TGTACACCTGGGGGCCATAGACATGTATCTGCGAAAACGTGGCCACCTGGTGCCAGCCAGCTGGAAGCTGCAGGTGGTCAAACAGCTGGC
CTACGCCCTCAACTATCTGGAGGACAAAGGCCTGCCCCATGGCAATGTCTCTGCCCGGAAGGTGCTCCTGGCTCGGGAGGGGGCTGATGG
GAGCCCGCCCTTCATCAAGCTGAGTGACCCTGGGGTCAGCCCCGCTGTGTTAAGCCTGGAGATGCTCACCGACAGGATCCCCTGGGTGGC
CCCCGAGTGTCTCCGGGAGGCGCAGACACTTAGCTTGGAAGCTGACAAGTGGGGCTTCGGCGCCACGGTCTGGGAAGTGTTTAGTGGCGT
CACCATGCCCATCAGTGCCCTGGATCCTGCTAAGAAACTCCAATTTTATGAGGACCGGCAGCAGCTGCCGGCCCCCAAGTGGACAGAGCT
GGCCCTGCTGATTCAACAGTGCATGGCCTATGAGCCGGTCCAGAGGCCCTCCTTCCGAGCCGTCATTCGTGACCTCAATAGCCTCATCTC
TTCAGACTATGAGCTCCTCTCAGACCCCACACCTGGTGCCCTGGCACCTCGTGATGGGCTGTGGAATGGTGCCCAGCTCTATGCCTGCCA
AGACCCCACGATCTTCGAGGAGAGACACCTCAAGTACATCTCACAGCTGGGCAAGGGCAACTTTGGCAGCGTGGAGCTGTGCCGCTATGA
CCCGCTAGGCGACAATACAGGTGCCCTGGTGGCCGTGAAACAGCTGCAGCACAGCGGGCCAGACCAGCAGAGGGACTTTCAGCGGGAGAT
TCAGATCCTCAAAGCACTGCACAGTGATTTCATTGTCAAGTATCGTGGTGTCAGCTATGGCCCGGGCCGCCAGAGCCTGCGGCTGGTCAT
GGAGTACCTGCCCAGCGGCTGCTTGCGCGACTTCCTGCAGCGGCACCGCGCGCGCCTCGATGCCAGCCGCCTCCTTCTCTATTCCTCGCA
GATCTGCAAGGGCATGGAGTACCTGGGCTCCCGCCGCTGCGTGCACCGCGACCTGGCCGCCCGAAACATCCTCGTGGAGAGCGAGGCACA
CGTCAAGATCGCTGACTTCGGCCTAGCTAAGCTGCTGCCGCTTGACAAAGACTACTACGTGGTCCGCGAGCCAGGCCAGAGCCCCATTTT
CTGGTATGCCCCCGAATCCCTCTCGGACAACATCTTCTCTCGCCAGTCAGACGTCTGGAGCTTCGGGGTCGTCCTGTACGAGCTCTTCAC
CTACTGCGACAAAAGCTGCAGCCCCTCGGCCGAGTTCCTGCGGATGATGGGATGTGAGCGGGATGTCCCCGCCCTCTGCCGCCTCTTGGA
ACTGCTGGAGGAGGGCCAGAGGCTGCCGGCGCCTCCTGCCTGCCCTGCTGAGGTGAGCGCCGCAGGGCTAGCCTCAGTTTCCCAGTCTGT
AGATTGGGCCGGGGTCTCGGGCAAGCCAGCTGGCGCCTGAGTCTCTGTACTGAGAAGAAAGGCTAGAGTGTGAGGCCGATGAGGATCCTG
GCCCCCACTTGGCTACTCTCTCACTGTGTGGCAAGTCAGAGCACTTTCAGAGCCTCAGTTTACCCTTTTCCAAAATGAGAATAGTAATGC
CTTATAGGGTGAGGGAAGATTAGACTCCTGAACACCTGTGCCTATGAGGGCTCAGCTCAAAGCCGAGCACACAGTCGATGCTCCATAAAT

>71104_71104_2_R3HDM4-JAK3_R3HDM4_chr19_913086_ENST00000361574_JAK3_chr19_17953981_ENST00000534444_length(amino acids)=950AA_BP=
MVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSL
MAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTD
NQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLT
VCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQS
QYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAG
DSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEML
TDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVI
RDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQ
QRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARN
ILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDV

--------------------------------------------------------------
>71104_71104_3_R3HDM4-JAK3_R3HDM4_chr19_913086_ENST00000587975_JAK3_chr19_17953981_ENST00000458235_length(transcript)=5066nt_BP=154nt
GCCCGCCTCCGGGCGCCCGTCACTTCCTGCCCGGCCCGGTGAAGGCCCTGCCGGGCGGCGGCGGCGGCGACAGCGTGCGAGCCATGGTCG
CGCTGGAGAACCCCGAGTGCGGCCCGGAGGCGGCGGAGGGCACCCCGGGCGGGCGGCGGCTGCTCACCGCAGTGACCTGGTGAGTGGGCG
CCTCCCCGTGGGCCTCAGTCTCAAGGAGCAGGGTGAGTGTCTCAGCCTGGCCGTGTTGGACCTGGCCCGGATGGCGCGAGAGCAGGCCCA
GCGGCCGGGAGAGCTGCTGAAGACTGTCAGCTACAAGGCCTGCCTACCCCCAAGCCTGCGCGACCTGATCCAGGGCCTGAGCTTCGTGAC
GCGGAGGCGTATTCGGAGGACGGTGCGCAGAGCCCTGCGCCGCGTGGCCGCCTGCCAGGCAGACCGGCACTCGCTCATGGCCAAGTACAT
CATGGACCTGGAGCGGCTGGATCCAGCCGGGGCCGCCGAGACCTTCCACGTGGGCCTCCCTGGGGCCCTTGGTGGCCACGACGGGCTGGG
GCTGCTCCGCGTGGCTGGTGACGGCGGCATCGCCTGGACCCAGGGAGAACAGGAGGTCCTCCAGCCCTTCTGCGACTTTCCAGAAATCGT
AGACATTAGCATCAAGCAGGCCCCGCGCGTTGGCCCGGCCGGAGAGCACCGCCTGGTCACTGTTACCAGGACAGACAACCAGATTTTAGA
GGCCGAGTTCCCAGGGCTGCCCGAGGCTCTGTCGTTCGTGGCGCTCGTGGACGGCTACTTCCGGCTGACCACGGACTCCCAGCACTTCTT
CTGCAAGGAGGTGGCACCGCCGAGGCTGCTGGAGGAAGTGGCCGAGCAGTGCCACGGCCCCATCACTCTGGACTTTGCCATCAACAAGCT
CAAGACTGGGGGCTCACGTCCTGGCTCCTATGTTCTCCGCCGCAGCCCCCAGGACTTTGACAGCTTCCTCCTCACTGTCTGTGTCCAGAA
CCCCCTTGGTCCTGATTATAAGGGCTGCCTCATCCGGCGCAGCCCCACAGGAACCTTCCTTCTGGTTGGCCTCAGCCGACCCCACAGCAG
TCTTCGAGAGCTCCTGGCAACCTGCTGGGATGGGGGGCTGCACGTAGATGGGGTGGCAGTGACCCTCACTTCCTGCTGTATCCCCAGACC
CAAAGAAAAGTCCAACCTGATCGTGGTCCAGAGAGGTCACAGCCCACCCACATCATCCTTGGTTCAGCCCCAATCCCAATACCAGCTGAG
TCAGATGACATTTCACAAGATCCCTGCTGACAGCCTGGAGTGGCATGAGAACCTGGGCCATGGGTCCTTCACCAAGATTTACCGGGGCTG
TCGCCATGAGGTGGTGGATGGGGAGGCCCGAAAGACAGAGGTGCTGCTGAAGGTCATGGATGCCAAGCACAAGAACTGCATGGAGTCATT
CCTGGAAGCAGCGAGCTTGATGAGCCAAGTGTCGTACCGGCATCTCGTGCTGCTCCACGGCGTGTGCATGGCTGGAGACAGCACCATGGT
GCAGGAATTTGTACACCTGGGGGCCATAGACATGTATCTGCGAAAACGTGGCCACCTGGTGCCAGCCAGCTGGAAGCTGCAGGTGGTCAA
ACAGCTGGCCTACGCCCTCAACTATCTGGAGGACAAAGGCCTGCCCCATGGCAATGTCTCTGCCCGGAAGGTGCTCCTGGCTCGGGAGGG
GGCTGATGGGAGCCCGCCCTTCATCAAGCTGAGTGACCCTGGGGTCAGCCCCGCTGTGTTAAGCCTGGAGATGCTCACCGACAGGATCCC
CTGGGTGGCCCCCGAGTGTCTCCGGGAGGCGCAGACACTTAGCTTGGAAGCTGACAAGTGGGGCTTCGGCGCCACGGTCTGGGAAGTGTT
TAGTGGCGTCACCATGCCCATCAGTGCCCTGGATCCTGCTAAGAAACTCCAATTTTATGAGGACCGGCAGCAGCTGCCGGCCCCCAAGTG
GACAGAGCTGGCCCTGCTGATTCAACAGTGCATGGCCTATGAGCCGGTCCAGAGGCCCTCCTTCCGAGCCGTCATTCGTGACCTCAATAG
CCTCATCTCTTCAGACTATGAGCTCCTCTCAGACCCCACACCTGGTGCCCTGGCACCTCGTGATGGGCTGTGGAATGGTGCCCAGCTCTA
TGCCTGCCAAGACCCCACGATCTTCGAGGAGAGACACCTCAAGTACATCTCACAGCTGGGCAAGGGCAACTTTGGCAGCGTGGAGCTGTG
CCGCTATGACCCGCTAGGCGACAATACAGGTGCCCTGGTGGCCGTGAAACAGCTGCAGCACAGCGGGCCAGACCAGCAGAGGGACTTTCA
GCGGGAGATTCAGATCCTCAAAGCACTGCACAGTGATTTCATTGTCAAGTATCGTGGTGTCAGCTATGGCCCGGGCCGCCAGAGCCTGCG
GCTGGTCATGGAGTACCTGCCCAGCGGCTGCTTGCGCGACTTCCTGCAGCGGCACCGCGCGCGCCTCGATGCCAGCCGCCTCCTTCTCTA
TTCCTCGCAGATCTGCAAGGGCATGGAGTACCTGGGCTCCCGCCGCTGCGTGCACCGCGACCTGGCCGCCCGAAACATCCTCGTGGAGAG
CGAGGCACACGTCAAGATCGCTGACTTCGGCCTAGCTAAGCTGCTGCCGCTTGACAAAGACTACTACGTGGTCCGCGAGCCAGGCCAGAG
CCCCATTTTCTGGTATGCCCCCGAATCCCTCTCGGACAACATCTTCTCTCGCCAGTCAGACGTCTGGAGCTTCGGGGTCGTCCTGTACGA
GCTCTTCACCTACTGCGACAAAAGCTGCAGCCCCTCGGCCGAGTTCCTGCGGATGATGGGATGTGAGCGGGATGTCCCCGCCCTCTGCCG
CCTCTTGGAACTGCTGGAGGAGGGCCAGAGGCTGCCGGCGCCTCCTGCCTGCCCTGCTGAGGTTCACGAGCTCATGAAGCTGTGCTGGGC
CCCTAGCCCACAGGACCGGCCATCATTCAGCGCCCTGGGCCCCCAGCTGGACATGCTGTGGAGCGGAAGCCGGGGGTGTGAGACTCATGC
CTTCACTGCTCACCCAGAGGGCAAACACCACTCCCTGTCCTTTTCATAGCTCCTGCCCGCAGACCTCTGGATTAGGTCTCTGTTGACTGG
CTGTGTGACCTTAGGCCCGGAGCTGCCCCTCTCTGGGCCTCAGAGGCCTTATGAGGGTCCTCTACTTCAGGAACACCCCCATGACATTGC
ATTTGGGGGGGCTCCCGTGGCCTGTAGAATAGCCTGTGGCCTTTGCAATTTGTTAAGGTTCAAGACAGATGGGCATATGTGTCAGTGGGG
CTCTCTGAGTCCTGGCCCAAAGAAGCAAGGAACCAAATTTAAGACTCTCGCATCTTCCCAACCCCTTAAGCCCTGGCCCCCTGAGTTTCC
TTTTCTGTCTCTCTCTTTTTATTTTTTTTATTTTTATTTTTATTTTTGAGACAGAGCCTCGCTCTGTTACCCAGGGTGGAGTGCAGTGGT
GCGATCTCGGCTCAGTGCAACCTCTGCTTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGTGTGCAC
CACCACACCCGGCTAATTTTTTTTATTTTTAATAGAGATGAGGTTTCACCATGATGGCCAGGCTGATCTCGAACTCCTAACCTCAAGTGA
TCCTCCCACCTCAGCCTCCCAAAGTGTTGGAATAATAGGCATGAGCCACTGCACCCAGGCTTTTTTTTTTTTAAATTTATTATTATTATT
TTTAAGAGACAGGATCTTGCTACGTTGCCCAGGCTGGTCTTGAACTCCTGGGCTACAGTGATCCTCCTGCCTTATCCTCCTAAATAGCTG
GGACTACAGCACCTAGTTTTGAGTTTCCTGTCTTATTTCCAATGGGGACATTCATGTAGCTTTTTTTTTTTTTTTTTTTTTGAGACGGAG
TCTCGCTCTGTCGCCCAGGCTGGAGTACAGTGGCGCAATCTAGGCTCACTGCAAGCTCCGCCTCCTGGGTTCACACCATTCTCTCGCCTC
AGCCTCCCAAGTAGCTGGGACTACAGGCGCCCGCCACCACACCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCTTGTTA
GCCAGGATGGTTTCCATCTCCTGACCTCGTGATCTGCCCGTCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGG
CCCTCATGTAGCTTTAAATGTATGATCTGACTTCTGCTCCCCGATCTCTGTTTCTCTGGAGGAAGCCAAGGACAAGAGCAGTTGCTGTGG
CTGGGACTCTGCCTTTTAGGGGAGCCCGTGTATCTCTTTGGGATCCTGAAAGGGGGCAGGAAAGGCTGGGGTCCCAGTCCACCCTAATGG
TATCTGAGTGTCCTAGGGCTTCAGTTTTCCCACCTGTCCAATGGGACCCTTTCTGTCCTCACCCTACAAGGGGCACAAAGGGATGACACC
AAACCTGGCAGGAACTTTTCACGCAATCAAGGGAAGGAAAGGCATTCCTGGCAGAGGGAACAGCATGCCAAGCGTGAGAAGGCTCAGAGT
AAGGAGGTTAAGAGCCCAAGTATTGGAGCCTACAGTTTTGCCCCTTCCATGCAGTGTGACAGTGGGCAAGTTCCTTTCCCTCTCTGGGTC
TCAGTTCTGTCCCCTGCAAAATGGTCAGAGCTTACCCCTTGGCTGTGCAGGGTCAACTTTCTGACTGGTGAGAGGGATTCTCATGCAGGT
TAAGCTTCTGCTGCTCCTCCTCACCTGCAAAGCTTTTCTGCCACTTTTGCCTCCTTGGAAAACTCTTATCCATCTCTCAAAACTCCAGCT
ACCACATCCTTGCAGCCTTCCCTCATATACCCCCACTACTACTGTAGCCCTGTCCTTCCCTCCAGCCCCACTCTGGCCCTGGGGCTGGGG
AAGTGTCTGTGTCCAGCTGTCTCCCCTGACCTCAGGGTTCCTTGGGGGCTGGGCTGAGGCCTCAGTACAGAGGGGGCTCTGGAAATGTTT

>71104_71104_3_R3HDM4-JAK3_R3HDM4_chr19_913086_ENST00000587975_JAK3_chr19_17953981_ENST00000458235_length(amino acids)=980AA_BP=
MVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSL
MAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTD
NQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLT
VCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQS
QYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAG
DSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEML
TDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVI
RDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQ
QRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARN
ILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDV

--------------------------------------------------------------
>71104_71104_4_R3HDM4-JAK3_R3HDM4_chr19_913086_ENST00000587975_JAK3_chr19_17953981_ENST00000534444_length(transcript)=3261nt_BP=154nt
GCCCGCCTCCGGGCGCCCGTCACTTCCTGCCCGGCCCGGTGAAGGCCCTGCCGGGCGGCGGCGGCGGCGACAGCGTGCGAGCCATGGTCG
CGCTGGAGAACCCCGAGTGCGGCCCGGAGGCGGCGGAGGGCACCCCGGGCGGGCGGCGGCTGCTCACCGCAGTGACCTGGTGAGTGGGCG
CCTCCCCGTGGGCCTCAGTCTCAAGGAGCAGGGTGAGTGTCTCAGCCTGGCCGTGTTGGACCTGGCCCGGATGGCGCGAGAGCAGGCCCA
GCGGCCGGGAGAGCTGCTGAAGACTGTCAGCTACAAGGCCTGCCTACCCCCAAGCCTGCGCGACCTGATCCAGGGCCTGAGCTTCGTGAC
GCGGAGGCGTATTCGGAGGACGGTGCGCAGAGCCCTGCGCCGCGTGGCCGCCTGCCAGGCAGACCGGCACTCGCTCATGGCCAAGTACAT
CATGGACCTGGAGCGGCTGGATCCAGCCGGGGCCGCCGAGACCTTCCACGTGGGCCTCCCTGGGGCCCTTGGTGGCCACGACGGGCTGGG
GCTGCTCCGCGTGGCTGGTGACGGCGGCATCGCCTGGACCCAGGGAGAACAGGAGGTCCTCCAGCCCTTCTGCGACTTTCCAGAAATCGT
AGACATTAGCATCAAGCAGGCCCCGCGCGTTGGCCCGGCCGGAGAGCACCGCCTGGTCACTGTTACCAGGACAGACAACCAGATTTTAGA
GGCCGAGTTCCCAGGGCTGCCCGAGGCTCTGTCGTTCGTGGCGCTCGTGGACGGCTACTTCCGGCTGACCACGGACTCCCAGCACTTCTT
CTGCAAGGAGGTGGCACCGCCGAGGCTGCTGGAGGAAGTGGCCGAGCAGTGCCACGGCCCCATCACTCTGGACTTTGCCATCAACAAGCT
CAAGACTGGGGGCTCACGTCCTGGCTCCTATGTTCTCCGCCGCAGCCCCCAGGACTTTGACAGCTTCCTCCTCACTGTCTGTGTCCAGAA
CCCCCTTGGTCCTGATTATAAGGGCTGCCTCATCCGGCGCAGCCCCACAGGAACCTTCCTTCTGGTTGGCCTCAGCCGACCCCACAGCAG
TCTTCGAGAGCTCCTGGCAACCTGCTGGGATGGGGGGCTGCACGTAGATGGGGTGGCAGTGACCCTCACTTCCTGCTGTATCCCCAGACC
CAAAGAAAAGTCCAACCTGATCGTGGTCCAGAGAGGTCACAGCCCACCCACATCATCCTTGGTTCAGCCCCAATCCCAATACCAGCTGAG
TCAGATGACATTTCACAAGATCCCTGCTGACAGCCTGGAGTGGCATGAGAACCTGGGCCATGGGTCCTTCACCAAGATTTACCGGGGCTG
TCGCCATGAGGTGGTGGATGGGGAGGCCCGAAAGACAGAGGTGCTGCTGAAGGTCATGGATGCCAAGCACAAGAACTGCATGGAGTCATT
CCTGGAAGCAGCGAGCTTGATGAGCCAAGTGTCGTACCGGCATCTCGTGCTGCTCCACGGCGTGTGCATGGCTGGAGACAGCACCATGGT
GCAGGAATTTGTACACCTGGGGGCCATAGACATGTATCTGCGAAAACGTGGCCACCTGGTGCCAGCCAGCTGGAAGCTGCAGGTGGTCAA
ACAGCTGGCCTACGCCCTCAACTATCTGGAGGACAAAGGCCTGCCCCATGGCAATGTCTCTGCCCGGAAGGTGCTCCTGGCTCGGGAGGG
GGCTGATGGGAGCCCGCCCTTCATCAAGCTGAGTGACCCTGGGGTCAGCCCCGCTGTGTTAAGCCTGGAGATGCTCACCGACAGGATCCC
CTGGGTGGCCCCCGAGTGTCTCCGGGAGGCGCAGACACTTAGCTTGGAAGCTGACAAGTGGGGCTTCGGCGCCACGGTCTGGGAAGTGTT
TAGTGGCGTCACCATGCCCATCAGTGCCCTGGATCCTGCTAAGAAACTCCAATTTTATGAGGACCGGCAGCAGCTGCCGGCCCCCAAGTG
GACAGAGCTGGCCCTGCTGATTCAACAGTGCATGGCCTATGAGCCGGTCCAGAGGCCCTCCTTCCGAGCCGTCATTCGTGACCTCAATAG
CCTCATCTCTTCAGACTATGAGCTCCTCTCAGACCCCACACCTGGTGCCCTGGCACCTCGTGATGGGCTGTGGAATGGTGCCCAGCTCTA
TGCCTGCCAAGACCCCACGATCTTCGAGGAGAGACACCTCAAGTACATCTCACAGCTGGGCAAGGGCAACTTTGGCAGCGTGGAGCTGTG
CCGCTATGACCCGCTAGGCGACAATACAGGTGCCCTGGTGGCCGTGAAACAGCTGCAGCACAGCGGGCCAGACCAGCAGAGGGACTTTCA
GCGGGAGATTCAGATCCTCAAAGCACTGCACAGTGATTTCATTGTCAAGTATCGTGGTGTCAGCTATGGCCCGGGCCGCCAGAGCCTGCG
GCTGGTCATGGAGTACCTGCCCAGCGGCTGCTTGCGCGACTTCCTGCAGCGGCACCGCGCGCGCCTCGATGCCAGCCGCCTCCTTCTCTA
TTCCTCGCAGATCTGCAAGGGCATGGAGTACCTGGGCTCCCGCCGCTGCGTGCACCGCGACCTGGCCGCCCGAAACATCCTCGTGGAGAG
CGAGGCACACGTCAAGATCGCTGACTTCGGCCTAGCTAAGCTGCTGCCGCTTGACAAAGACTACTACGTGGTCCGCGAGCCAGGCCAGAG
CCCCATTTTCTGGTATGCCCCCGAATCCCTCTCGGACAACATCTTCTCTCGCCAGTCAGACGTCTGGAGCTTCGGGGTCGTCCTGTACGA
GCTCTTCACCTACTGCGACAAAAGCTGCAGCCCCTCGGCCGAGTTCCTGCGGATGATGGGATGTGAGCGGGATGTCCCCGCCCTCTGCCG
CCTCTTGGAACTGCTGGAGGAGGGCCAGAGGCTGCCGGCGCCTCCTGCCTGCCCTGCTGAGGTGAGCGCCGCAGGGCTAGCCTCAGTTTC
CCAGTCTGTAGATTGGGCCGGGGTCTCGGGCAAGCCAGCTGGCGCCTGAGTCTCTGTACTGAGAAGAAAGGCTAGAGTGTGAGGCCGATG
AGGATCCTGGCCCCCACTTGGCTACTCTCTCACTGTGTGGCAAGTCAGAGCACTTTCAGAGCCTCAGTTTACCCTTTTCCAAAATGAGAA
TAGTAATGCCTTATAGGGTGAGGGAAGATTAGACTCCTGAACACCTGTGCCTATGAGGGCTCAGCTCAAAGCCGAGCACACAGTCGATGC

>71104_71104_4_R3HDM4-JAK3_R3HDM4_chr19_913086_ENST00000587975_JAK3_chr19_17953981_ENST00000534444_length(amino acids)=950AA_BP=
MVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSL
MAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTD
NQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLT
VCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQS
QYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAG
DSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEML
TDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVI
RDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQ
QRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARN
ILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDV

--------------------------------------------------------------
>71104_71104_5_R3HDM4-JAK3_R3HDM4_chr19_913087_ENST00000361574_JAK3_chr19_17953981_ENST00000458235_length(transcript)=5057nt_BP=145nt
CGGGCGCCCGTCACTTCCTGCCCGGCCCGGTGAAGGCCCTGCCGGGCGGCGGCGGCGGCGACAGCGTGCGAGCCATGGTCGCGCTGGAGA
ACCCCGAGTGCGGCCCGGAGGCGGCGGAGGGCACCCCGGGCGGGCGGCGGCTGCTCACCGCAGTGACCTGGTGAGTGGGCGCCTCCCCGT
GGGCCTCAGTCTCAAGGAGCAGGGTGAGTGTCTCAGCCTGGCCGTGTTGGACCTGGCCCGGATGGCGCGAGAGCAGGCCCAGCGGCCGGG
AGAGCTGCTGAAGACTGTCAGCTACAAGGCCTGCCTACCCCCAAGCCTGCGCGACCTGATCCAGGGCCTGAGCTTCGTGACGCGGAGGCG
TATTCGGAGGACGGTGCGCAGAGCCCTGCGCCGCGTGGCCGCCTGCCAGGCAGACCGGCACTCGCTCATGGCCAAGTACATCATGGACCT
GGAGCGGCTGGATCCAGCCGGGGCCGCCGAGACCTTCCACGTGGGCCTCCCTGGGGCCCTTGGTGGCCACGACGGGCTGGGGCTGCTCCG
CGTGGCTGGTGACGGCGGCATCGCCTGGACCCAGGGAGAACAGGAGGTCCTCCAGCCCTTCTGCGACTTTCCAGAAATCGTAGACATTAG
CATCAAGCAGGCCCCGCGCGTTGGCCCGGCCGGAGAGCACCGCCTGGTCACTGTTACCAGGACAGACAACCAGATTTTAGAGGCCGAGTT
CCCAGGGCTGCCCGAGGCTCTGTCGTTCGTGGCGCTCGTGGACGGCTACTTCCGGCTGACCACGGACTCCCAGCACTTCTTCTGCAAGGA
GGTGGCACCGCCGAGGCTGCTGGAGGAAGTGGCCGAGCAGTGCCACGGCCCCATCACTCTGGACTTTGCCATCAACAAGCTCAAGACTGG
GGGCTCACGTCCTGGCTCCTATGTTCTCCGCCGCAGCCCCCAGGACTTTGACAGCTTCCTCCTCACTGTCTGTGTCCAGAACCCCCTTGG
TCCTGATTATAAGGGCTGCCTCATCCGGCGCAGCCCCACAGGAACCTTCCTTCTGGTTGGCCTCAGCCGACCCCACAGCAGTCTTCGAGA
GCTCCTGGCAACCTGCTGGGATGGGGGGCTGCACGTAGATGGGGTGGCAGTGACCCTCACTTCCTGCTGTATCCCCAGACCCAAAGAAAA
GTCCAACCTGATCGTGGTCCAGAGAGGTCACAGCCCACCCACATCATCCTTGGTTCAGCCCCAATCCCAATACCAGCTGAGTCAGATGAC
ATTTCACAAGATCCCTGCTGACAGCCTGGAGTGGCATGAGAACCTGGGCCATGGGTCCTTCACCAAGATTTACCGGGGCTGTCGCCATGA
GGTGGTGGATGGGGAGGCCCGAAAGACAGAGGTGCTGCTGAAGGTCATGGATGCCAAGCACAAGAACTGCATGGAGTCATTCCTGGAAGC
AGCGAGCTTGATGAGCCAAGTGTCGTACCGGCATCTCGTGCTGCTCCACGGCGTGTGCATGGCTGGAGACAGCACCATGGTGCAGGAATT
TGTACACCTGGGGGCCATAGACATGTATCTGCGAAAACGTGGCCACCTGGTGCCAGCCAGCTGGAAGCTGCAGGTGGTCAAACAGCTGGC
CTACGCCCTCAACTATCTGGAGGACAAAGGCCTGCCCCATGGCAATGTCTCTGCCCGGAAGGTGCTCCTGGCTCGGGAGGGGGCTGATGG
GAGCCCGCCCTTCATCAAGCTGAGTGACCCTGGGGTCAGCCCCGCTGTGTTAAGCCTGGAGATGCTCACCGACAGGATCCCCTGGGTGGC
CCCCGAGTGTCTCCGGGAGGCGCAGACACTTAGCTTGGAAGCTGACAAGTGGGGCTTCGGCGCCACGGTCTGGGAAGTGTTTAGTGGCGT
CACCATGCCCATCAGTGCCCTGGATCCTGCTAAGAAACTCCAATTTTATGAGGACCGGCAGCAGCTGCCGGCCCCCAAGTGGACAGAGCT
GGCCCTGCTGATTCAACAGTGCATGGCCTATGAGCCGGTCCAGAGGCCCTCCTTCCGAGCCGTCATTCGTGACCTCAATAGCCTCATCTC
TTCAGACTATGAGCTCCTCTCAGACCCCACACCTGGTGCCCTGGCACCTCGTGATGGGCTGTGGAATGGTGCCCAGCTCTATGCCTGCCA
AGACCCCACGATCTTCGAGGAGAGACACCTCAAGTACATCTCACAGCTGGGCAAGGGCAACTTTGGCAGCGTGGAGCTGTGCCGCTATGA
CCCGCTAGGCGACAATACAGGTGCCCTGGTGGCCGTGAAACAGCTGCAGCACAGCGGGCCAGACCAGCAGAGGGACTTTCAGCGGGAGAT
TCAGATCCTCAAAGCACTGCACAGTGATTTCATTGTCAAGTATCGTGGTGTCAGCTATGGCCCGGGCCGCCAGAGCCTGCGGCTGGTCAT
GGAGTACCTGCCCAGCGGCTGCTTGCGCGACTTCCTGCAGCGGCACCGCGCGCGCCTCGATGCCAGCCGCCTCCTTCTCTATTCCTCGCA
GATCTGCAAGGGCATGGAGTACCTGGGCTCCCGCCGCTGCGTGCACCGCGACCTGGCCGCCCGAAACATCCTCGTGGAGAGCGAGGCACA
CGTCAAGATCGCTGACTTCGGCCTAGCTAAGCTGCTGCCGCTTGACAAAGACTACTACGTGGTCCGCGAGCCAGGCCAGAGCCCCATTTT
CTGGTATGCCCCCGAATCCCTCTCGGACAACATCTTCTCTCGCCAGTCAGACGTCTGGAGCTTCGGGGTCGTCCTGTACGAGCTCTTCAC
CTACTGCGACAAAAGCTGCAGCCCCTCGGCCGAGTTCCTGCGGATGATGGGATGTGAGCGGGATGTCCCCGCCCTCTGCCGCCTCTTGGA
ACTGCTGGAGGAGGGCCAGAGGCTGCCGGCGCCTCCTGCCTGCCCTGCTGAGGTTCACGAGCTCATGAAGCTGTGCTGGGCCCCTAGCCC
ACAGGACCGGCCATCATTCAGCGCCCTGGGCCCCCAGCTGGACATGCTGTGGAGCGGAAGCCGGGGGTGTGAGACTCATGCCTTCACTGC
TCACCCAGAGGGCAAACACCACTCCCTGTCCTTTTCATAGCTCCTGCCCGCAGACCTCTGGATTAGGTCTCTGTTGACTGGCTGTGTGAC
CTTAGGCCCGGAGCTGCCCCTCTCTGGGCCTCAGAGGCCTTATGAGGGTCCTCTACTTCAGGAACACCCCCATGACATTGCATTTGGGGG
GGCTCCCGTGGCCTGTAGAATAGCCTGTGGCCTTTGCAATTTGTTAAGGTTCAAGACAGATGGGCATATGTGTCAGTGGGGCTCTCTGAG
TCCTGGCCCAAAGAAGCAAGGAACCAAATTTAAGACTCTCGCATCTTCCCAACCCCTTAAGCCCTGGCCCCCTGAGTTTCCTTTTCTGTC
TCTCTCTTTTTATTTTTTTTATTTTTATTTTTATTTTTGAGACAGAGCCTCGCTCTGTTACCCAGGGTGGAGTGCAGTGGTGCGATCTCG
GCTCAGTGCAACCTCTGCTTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGTGTGCACCACCACACC
CGGCTAATTTTTTTTATTTTTAATAGAGATGAGGTTTCACCATGATGGCCAGGCTGATCTCGAACTCCTAACCTCAAGTGATCCTCCCAC
CTCAGCCTCCCAAAGTGTTGGAATAATAGGCATGAGCCACTGCACCCAGGCTTTTTTTTTTTTAAATTTATTATTATTATTTTTAAGAGA
CAGGATCTTGCTACGTTGCCCAGGCTGGTCTTGAACTCCTGGGCTACAGTGATCCTCCTGCCTTATCCTCCTAAATAGCTGGGACTACAG
CACCTAGTTTTGAGTTTCCTGTCTTATTTCCAATGGGGACATTCATGTAGCTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCT
GTCGCCCAGGCTGGAGTACAGTGGCGCAATCTAGGCTCACTGCAAGCTCCGCCTCCTGGGTTCACACCATTCTCTCGCCTCAGCCTCCCA
AGTAGCTGGGACTACAGGCGCCCGCCACCACACCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCTTGTTAGCCAGGATG
GTTTCCATCTCCTGACCTCGTGATCTGCCCGTCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCTCATGT
AGCTTTAAATGTATGATCTGACTTCTGCTCCCCGATCTCTGTTTCTCTGGAGGAAGCCAAGGACAAGAGCAGTTGCTGTGGCTGGGACTC
TGCCTTTTAGGGGAGCCCGTGTATCTCTTTGGGATCCTGAAAGGGGGCAGGAAAGGCTGGGGTCCCAGTCCACCCTAATGGTATCTGAGT
GTCCTAGGGCTTCAGTTTTCCCACCTGTCCAATGGGACCCTTTCTGTCCTCACCCTACAAGGGGCACAAAGGGATGACACCAAACCTGGC
AGGAACTTTTCACGCAATCAAGGGAAGGAAAGGCATTCCTGGCAGAGGGAACAGCATGCCAAGCGTGAGAAGGCTCAGAGTAAGGAGGTT
AAGAGCCCAAGTATTGGAGCCTACAGTTTTGCCCCTTCCATGCAGTGTGACAGTGGGCAAGTTCCTTTCCCTCTCTGGGTCTCAGTTCTG
TCCCCTGCAAAATGGTCAGAGCTTACCCCTTGGCTGTGCAGGGTCAACTTTCTGACTGGTGAGAGGGATTCTCATGCAGGTTAAGCTTCT
GCTGCTCCTCCTCACCTGCAAAGCTTTTCTGCCACTTTTGCCTCCTTGGAAAACTCTTATCCATCTCTCAAAACTCCAGCTACCACATCC
TTGCAGCCTTCCCTCATATACCCCCACTACTACTGTAGCCCTGTCCTTCCCTCCAGCCCCACTCTGGCCCTGGGGCTGGGGAAGTGTCTG
TGTCCAGCTGTCTCCCCTGACCTCAGGGTTCCTTGGGGGCTGGGCTGAGGCCTCAGTACAGAGGGGGCTCTGGAAATGTTTGTTGACTGA

>71104_71104_5_R3HDM4-JAK3_R3HDM4_chr19_913087_ENST00000361574_JAK3_chr19_17953981_ENST00000458235_length(amino acids)=980AA_BP=
MVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSL
MAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTD
NQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLT
VCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQS
QYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAG
DSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEML
TDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVI
RDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQ
QRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARN
ILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDV

--------------------------------------------------------------
>71104_71104_6_R3HDM4-JAK3_R3HDM4_chr19_913087_ENST00000361574_JAK3_chr19_17953981_ENST00000534444_length(transcript)=3252nt_BP=145nt
CGGGCGCCCGTCACTTCCTGCCCGGCCCGGTGAAGGCCCTGCCGGGCGGCGGCGGCGGCGACAGCGTGCGAGCCATGGTCGCGCTGGAGA
ACCCCGAGTGCGGCCCGGAGGCGGCGGAGGGCACCCCGGGCGGGCGGCGGCTGCTCACCGCAGTGACCTGGTGAGTGGGCGCCTCCCCGT
GGGCCTCAGTCTCAAGGAGCAGGGTGAGTGTCTCAGCCTGGCCGTGTTGGACCTGGCCCGGATGGCGCGAGAGCAGGCCCAGCGGCCGGG
AGAGCTGCTGAAGACTGTCAGCTACAAGGCCTGCCTACCCCCAAGCCTGCGCGACCTGATCCAGGGCCTGAGCTTCGTGACGCGGAGGCG
TATTCGGAGGACGGTGCGCAGAGCCCTGCGCCGCGTGGCCGCCTGCCAGGCAGACCGGCACTCGCTCATGGCCAAGTACATCATGGACCT
GGAGCGGCTGGATCCAGCCGGGGCCGCCGAGACCTTCCACGTGGGCCTCCCTGGGGCCCTTGGTGGCCACGACGGGCTGGGGCTGCTCCG
CGTGGCTGGTGACGGCGGCATCGCCTGGACCCAGGGAGAACAGGAGGTCCTCCAGCCCTTCTGCGACTTTCCAGAAATCGTAGACATTAG
CATCAAGCAGGCCCCGCGCGTTGGCCCGGCCGGAGAGCACCGCCTGGTCACTGTTACCAGGACAGACAACCAGATTTTAGAGGCCGAGTT
CCCAGGGCTGCCCGAGGCTCTGTCGTTCGTGGCGCTCGTGGACGGCTACTTCCGGCTGACCACGGACTCCCAGCACTTCTTCTGCAAGGA
GGTGGCACCGCCGAGGCTGCTGGAGGAAGTGGCCGAGCAGTGCCACGGCCCCATCACTCTGGACTTTGCCATCAACAAGCTCAAGACTGG
GGGCTCACGTCCTGGCTCCTATGTTCTCCGCCGCAGCCCCCAGGACTTTGACAGCTTCCTCCTCACTGTCTGTGTCCAGAACCCCCTTGG
TCCTGATTATAAGGGCTGCCTCATCCGGCGCAGCCCCACAGGAACCTTCCTTCTGGTTGGCCTCAGCCGACCCCACAGCAGTCTTCGAGA
GCTCCTGGCAACCTGCTGGGATGGGGGGCTGCACGTAGATGGGGTGGCAGTGACCCTCACTTCCTGCTGTATCCCCAGACCCAAAGAAAA
GTCCAACCTGATCGTGGTCCAGAGAGGTCACAGCCCACCCACATCATCCTTGGTTCAGCCCCAATCCCAATACCAGCTGAGTCAGATGAC
ATTTCACAAGATCCCTGCTGACAGCCTGGAGTGGCATGAGAACCTGGGCCATGGGTCCTTCACCAAGATTTACCGGGGCTGTCGCCATGA
GGTGGTGGATGGGGAGGCCCGAAAGACAGAGGTGCTGCTGAAGGTCATGGATGCCAAGCACAAGAACTGCATGGAGTCATTCCTGGAAGC
AGCGAGCTTGATGAGCCAAGTGTCGTACCGGCATCTCGTGCTGCTCCACGGCGTGTGCATGGCTGGAGACAGCACCATGGTGCAGGAATT
TGTACACCTGGGGGCCATAGACATGTATCTGCGAAAACGTGGCCACCTGGTGCCAGCCAGCTGGAAGCTGCAGGTGGTCAAACAGCTGGC
CTACGCCCTCAACTATCTGGAGGACAAAGGCCTGCCCCATGGCAATGTCTCTGCCCGGAAGGTGCTCCTGGCTCGGGAGGGGGCTGATGG
GAGCCCGCCCTTCATCAAGCTGAGTGACCCTGGGGTCAGCCCCGCTGTGTTAAGCCTGGAGATGCTCACCGACAGGATCCCCTGGGTGGC
CCCCGAGTGTCTCCGGGAGGCGCAGACACTTAGCTTGGAAGCTGACAAGTGGGGCTTCGGCGCCACGGTCTGGGAAGTGTTTAGTGGCGT
CACCATGCCCATCAGTGCCCTGGATCCTGCTAAGAAACTCCAATTTTATGAGGACCGGCAGCAGCTGCCGGCCCCCAAGTGGACAGAGCT
GGCCCTGCTGATTCAACAGTGCATGGCCTATGAGCCGGTCCAGAGGCCCTCCTTCCGAGCCGTCATTCGTGACCTCAATAGCCTCATCTC
TTCAGACTATGAGCTCCTCTCAGACCCCACACCTGGTGCCCTGGCACCTCGTGATGGGCTGTGGAATGGTGCCCAGCTCTATGCCTGCCA
AGACCCCACGATCTTCGAGGAGAGACACCTCAAGTACATCTCACAGCTGGGCAAGGGCAACTTTGGCAGCGTGGAGCTGTGCCGCTATGA
CCCGCTAGGCGACAATACAGGTGCCCTGGTGGCCGTGAAACAGCTGCAGCACAGCGGGCCAGACCAGCAGAGGGACTTTCAGCGGGAGAT
TCAGATCCTCAAAGCACTGCACAGTGATTTCATTGTCAAGTATCGTGGTGTCAGCTATGGCCCGGGCCGCCAGAGCCTGCGGCTGGTCAT
GGAGTACCTGCCCAGCGGCTGCTTGCGCGACTTCCTGCAGCGGCACCGCGCGCGCCTCGATGCCAGCCGCCTCCTTCTCTATTCCTCGCA
GATCTGCAAGGGCATGGAGTACCTGGGCTCCCGCCGCTGCGTGCACCGCGACCTGGCCGCCCGAAACATCCTCGTGGAGAGCGAGGCACA
CGTCAAGATCGCTGACTTCGGCCTAGCTAAGCTGCTGCCGCTTGACAAAGACTACTACGTGGTCCGCGAGCCAGGCCAGAGCCCCATTTT
CTGGTATGCCCCCGAATCCCTCTCGGACAACATCTTCTCTCGCCAGTCAGACGTCTGGAGCTTCGGGGTCGTCCTGTACGAGCTCTTCAC
CTACTGCGACAAAAGCTGCAGCCCCTCGGCCGAGTTCCTGCGGATGATGGGATGTGAGCGGGATGTCCCCGCCCTCTGCCGCCTCTTGGA
ACTGCTGGAGGAGGGCCAGAGGCTGCCGGCGCCTCCTGCCTGCCCTGCTGAGGTGAGCGCCGCAGGGCTAGCCTCAGTTTCCCAGTCTGT
AGATTGGGCCGGGGTCTCGGGCAAGCCAGCTGGCGCCTGAGTCTCTGTACTGAGAAGAAAGGCTAGAGTGTGAGGCCGATGAGGATCCTG
GCCCCCACTTGGCTACTCTCTCACTGTGTGGCAAGTCAGAGCACTTTCAGAGCCTCAGTTTACCCTTTTCCAAAATGAGAATAGTAATGC
CTTATAGGGTGAGGGAAGATTAGACTCCTGAACACCTGTGCCTATGAGGGCTCAGCTCAAAGCCGAGCACACAGTCGATGCTCCATAAAT

>71104_71104_6_R3HDM4-JAK3_R3HDM4_chr19_913087_ENST00000361574_JAK3_chr19_17953981_ENST00000534444_length(amino acids)=950AA_BP=
MVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSL
MAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTD
NQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLT
VCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQS
QYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAG
DSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEML
TDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVI
RDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQ
QRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARN
ILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDV

--------------------------------------------------------------
>71104_71104_7_R3HDM4-JAK3_R3HDM4_chr19_913087_ENST00000587975_JAK3_chr19_17953981_ENST00000458235_length(transcript)=5066nt_BP=154nt
GCCCGCCTCCGGGCGCCCGTCACTTCCTGCCCGGCCCGGTGAAGGCCCTGCCGGGCGGCGGCGGCGGCGACAGCGTGCGAGCCATGGTCG
CGCTGGAGAACCCCGAGTGCGGCCCGGAGGCGGCGGAGGGCACCCCGGGCGGGCGGCGGCTGCTCACCGCAGTGACCTGGTGAGTGGGCG
CCTCCCCGTGGGCCTCAGTCTCAAGGAGCAGGGTGAGTGTCTCAGCCTGGCCGTGTTGGACCTGGCCCGGATGGCGCGAGAGCAGGCCCA
GCGGCCGGGAGAGCTGCTGAAGACTGTCAGCTACAAGGCCTGCCTACCCCCAAGCCTGCGCGACCTGATCCAGGGCCTGAGCTTCGTGAC
GCGGAGGCGTATTCGGAGGACGGTGCGCAGAGCCCTGCGCCGCGTGGCCGCCTGCCAGGCAGACCGGCACTCGCTCATGGCCAAGTACAT
CATGGACCTGGAGCGGCTGGATCCAGCCGGGGCCGCCGAGACCTTCCACGTGGGCCTCCCTGGGGCCCTTGGTGGCCACGACGGGCTGGG
GCTGCTCCGCGTGGCTGGTGACGGCGGCATCGCCTGGACCCAGGGAGAACAGGAGGTCCTCCAGCCCTTCTGCGACTTTCCAGAAATCGT
AGACATTAGCATCAAGCAGGCCCCGCGCGTTGGCCCGGCCGGAGAGCACCGCCTGGTCACTGTTACCAGGACAGACAACCAGATTTTAGA
GGCCGAGTTCCCAGGGCTGCCCGAGGCTCTGTCGTTCGTGGCGCTCGTGGACGGCTACTTCCGGCTGACCACGGACTCCCAGCACTTCTT
CTGCAAGGAGGTGGCACCGCCGAGGCTGCTGGAGGAAGTGGCCGAGCAGTGCCACGGCCCCATCACTCTGGACTTTGCCATCAACAAGCT
CAAGACTGGGGGCTCACGTCCTGGCTCCTATGTTCTCCGCCGCAGCCCCCAGGACTTTGACAGCTTCCTCCTCACTGTCTGTGTCCAGAA
CCCCCTTGGTCCTGATTATAAGGGCTGCCTCATCCGGCGCAGCCCCACAGGAACCTTCCTTCTGGTTGGCCTCAGCCGACCCCACAGCAG
TCTTCGAGAGCTCCTGGCAACCTGCTGGGATGGGGGGCTGCACGTAGATGGGGTGGCAGTGACCCTCACTTCCTGCTGTATCCCCAGACC
CAAAGAAAAGTCCAACCTGATCGTGGTCCAGAGAGGTCACAGCCCACCCACATCATCCTTGGTTCAGCCCCAATCCCAATACCAGCTGAG
TCAGATGACATTTCACAAGATCCCTGCTGACAGCCTGGAGTGGCATGAGAACCTGGGCCATGGGTCCTTCACCAAGATTTACCGGGGCTG
TCGCCATGAGGTGGTGGATGGGGAGGCCCGAAAGACAGAGGTGCTGCTGAAGGTCATGGATGCCAAGCACAAGAACTGCATGGAGTCATT
CCTGGAAGCAGCGAGCTTGATGAGCCAAGTGTCGTACCGGCATCTCGTGCTGCTCCACGGCGTGTGCATGGCTGGAGACAGCACCATGGT
GCAGGAATTTGTACACCTGGGGGCCATAGACATGTATCTGCGAAAACGTGGCCACCTGGTGCCAGCCAGCTGGAAGCTGCAGGTGGTCAA
ACAGCTGGCCTACGCCCTCAACTATCTGGAGGACAAAGGCCTGCCCCATGGCAATGTCTCTGCCCGGAAGGTGCTCCTGGCTCGGGAGGG
GGCTGATGGGAGCCCGCCCTTCATCAAGCTGAGTGACCCTGGGGTCAGCCCCGCTGTGTTAAGCCTGGAGATGCTCACCGACAGGATCCC
CTGGGTGGCCCCCGAGTGTCTCCGGGAGGCGCAGACACTTAGCTTGGAAGCTGACAAGTGGGGCTTCGGCGCCACGGTCTGGGAAGTGTT
TAGTGGCGTCACCATGCCCATCAGTGCCCTGGATCCTGCTAAGAAACTCCAATTTTATGAGGACCGGCAGCAGCTGCCGGCCCCCAAGTG
GACAGAGCTGGCCCTGCTGATTCAACAGTGCATGGCCTATGAGCCGGTCCAGAGGCCCTCCTTCCGAGCCGTCATTCGTGACCTCAATAG
CCTCATCTCTTCAGACTATGAGCTCCTCTCAGACCCCACACCTGGTGCCCTGGCACCTCGTGATGGGCTGTGGAATGGTGCCCAGCTCTA
TGCCTGCCAAGACCCCACGATCTTCGAGGAGAGACACCTCAAGTACATCTCACAGCTGGGCAAGGGCAACTTTGGCAGCGTGGAGCTGTG
CCGCTATGACCCGCTAGGCGACAATACAGGTGCCCTGGTGGCCGTGAAACAGCTGCAGCACAGCGGGCCAGACCAGCAGAGGGACTTTCA
GCGGGAGATTCAGATCCTCAAAGCACTGCACAGTGATTTCATTGTCAAGTATCGTGGTGTCAGCTATGGCCCGGGCCGCCAGAGCCTGCG
GCTGGTCATGGAGTACCTGCCCAGCGGCTGCTTGCGCGACTTCCTGCAGCGGCACCGCGCGCGCCTCGATGCCAGCCGCCTCCTTCTCTA
TTCCTCGCAGATCTGCAAGGGCATGGAGTACCTGGGCTCCCGCCGCTGCGTGCACCGCGACCTGGCCGCCCGAAACATCCTCGTGGAGAG
CGAGGCACACGTCAAGATCGCTGACTTCGGCCTAGCTAAGCTGCTGCCGCTTGACAAAGACTACTACGTGGTCCGCGAGCCAGGCCAGAG
CCCCATTTTCTGGTATGCCCCCGAATCCCTCTCGGACAACATCTTCTCTCGCCAGTCAGACGTCTGGAGCTTCGGGGTCGTCCTGTACGA
GCTCTTCACCTACTGCGACAAAAGCTGCAGCCCCTCGGCCGAGTTCCTGCGGATGATGGGATGTGAGCGGGATGTCCCCGCCCTCTGCCG
CCTCTTGGAACTGCTGGAGGAGGGCCAGAGGCTGCCGGCGCCTCCTGCCTGCCCTGCTGAGGTTCACGAGCTCATGAAGCTGTGCTGGGC
CCCTAGCCCACAGGACCGGCCATCATTCAGCGCCCTGGGCCCCCAGCTGGACATGCTGTGGAGCGGAAGCCGGGGGTGTGAGACTCATGC
CTTCACTGCTCACCCAGAGGGCAAACACCACTCCCTGTCCTTTTCATAGCTCCTGCCCGCAGACCTCTGGATTAGGTCTCTGTTGACTGG
CTGTGTGACCTTAGGCCCGGAGCTGCCCCTCTCTGGGCCTCAGAGGCCTTATGAGGGTCCTCTACTTCAGGAACACCCCCATGACATTGC
ATTTGGGGGGGCTCCCGTGGCCTGTAGAATAGCCTGTGGCCTTTGCAATTTGTTAAGGTTCAAGACAGATGGGCATATGTGTCAGTGGGG
CTCTCTGAGTCCTGGCCCAAAGAAGCAAGGAACCAAATTTAAGACTCTCGCATCTTCCCAACCCCTTAAGCCCTGGCCCCCTGAGTTTCC
TTTTCTGTCTCTCTCTTTTTATTTTTTTTATTTTTATTTTTATTTTTGAGACAGAGCCTCGCTCTGTTACCCAGGGTGGAGTGCAGTGGT
GCGATCTCGGCTCAGTGCAACCTCTGCTTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGTGTGCAC
CACCACACCCGGCTAATTTTTTTTATTTTTAATAGAGATGAGGTTTCACCATGATGGCCAGGCTGATCTCGAACTCCTAACCTCAAGTGA
TCCTCCCACCTCAGCCTCCCAAAGTGTTGGAATAATAGGCATGAGCCACTGCACCCAGGCTTTTTTTTTTTTAAATTTATTATTATTATT
TTTAAGAGACAGGATCTTGCTACGTTGCCCAGGCTGGTCTTGAACTCCTGGGCTACAGTGATCCTCCTGCCTTATCCTCCTAAATAGCTG
GGACTACAGCACCTAGTTTTGAGTTTCCTGTCTTATTTCCAATGGGGACATTCATGTAGCTTTTTTTTTTTTTTTTTTTTTGAGACGGAG
TCTCGCTCTGTCGCCCAGGCTGGAGTACAGTGGCGCAATCTAGGCTCACTGCAAGCTCCGCCTCCTGGGTTCACACCATTCTCTCGCCTC
AGCCTCCCAAGTAGCTGGGACTACAGGCGCCCGCCACCACACCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCTTGTTA
GCCAGGATGGTTTCCATCTCCTGACCTCGTGATCTGCCCGTCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGG
CCCTCATGTAGCTTTAAATGTATGATCTGACTTCTGCTCCCCGATCTCTGTTTCTCTGGAGGAAGCCAAGGACAAGAGCAGTTGCTGTGG
CTGGGACTCTGCCTTTTAGGGGAGCCCGTGTATCTCTTTGGGATCCTGAAAGGGGGCAGGAAAGGCTGGGGTCCCAGTCCACCCTAATGG
TATCTGAGTGTCCTAGGGCTTCAGTTTTCCCACCTGTCCAATGGGACCCTTTCTGTCCTCACCCTACAAGGGGCACAAAGGGATGACACC
AAACCTGGCAGGAACTTTTCACGCAATCAAGGGAAGGAAAGGCATTCCTGGCAGAGGGAACAGCATGCCAAGCGTGAGAAGGCTCAGAGT
AAGGAGGTTAAGAGCCCAAGTATTGGAGCCTACAGTTTTGCCCCTTCCATGCAGTGTGACAGTGGGCAAGTTCCTTTCCCTCTCTGGGTC
TCAGTTCTGTCCCCTGCAAAATGGTCAGAGCTTACCCCTTGGCTGTGCAGGGTCAACTTTCTGACTGGTGAGAGGGATTCTCATGCAGGT
TAAGCTTCTGCTGCTCCTCCTCACCTGCAAAGCTTTTCTGCCACTTTTGCCTCCTTGGAAAACTCTTATCCATCTCTCAAAACTCCAGCT
ACCACATCCTTGCAGCCTTCCCTCATATACCCCCACTACTACTGTAGCCCTGTCCTTCCCTCCAGCCCCACTCTGGCCCTGGGGCTGGGG
AAGTGTCTGTGTCCAGCTGTCTCCCCTGACCTCAGGGTTCCTTGGGGGCTGGGCTGAGGCCTCAGTACAGAGGGGGCTCTGGAAATGTTT

>71104_71104_7_R3HDM4-JAK3_R3HDM4_chr19_913087_ENST00000587975_JAK3_chr19_17953981_ENST00000458235_length(amino acids)=980AA_BP=
MVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSL
MAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTD
NQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLT
VCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQS
QYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAG
DSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEML
TDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVI
RDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQ
QRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARN
ILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDV

--------------------------------------------------------------
>71104_71104_8_R3HDM4-JAK3_R3HDM4_chr19_913087_ENST00000587975_JAK3_chr19_17953981_ENST00000534444_length(transcript)=3261nt_BP=154nt
GCCCGCCTCCGGGCGCCCGTCACTTCCTGCCCGGCCCGGTGAAGGCCCTGCCGGGCGGCGGCGGCGGCGACAGCGTGCGAGCCATGGTCG
CGCTGGAGAACCCCGAGTGCGGCCCGGAGGCGGCGGAGGGCACCCCGGGCGGGCGGCGGCTGCTCACCGCAGTGACCTGGTGAGTGGGCG
CCTCCCCGTGGGCCTCAGTCTCAAGGAGCAGGGTGAGTGTCTCAGCCTGGCCGTGTTGGACCTGGCCCGGATGGCGCGAGAGCAGGCCCA
GCGGCCGGGAGAGCTGCTGAAGACTGTCAGCTACAAGGCCTGCCTACCCCCAAGCCTGCGCGACCTGATCCAGGGCCTGAGCTTCGTGAC
GCGGAGGCGTATTCGGAGGACGGTGCGCAGAGCCCTGCGCCGCGTGGCCGCCTGCCAGGCAGACCGGCACTCGCTCATGGCCAAGTACAT
CATGGACCTGGAGCGGCTGGATCCAGCCGGGGCCGCCGAGACCTTCCACGTGGGCCTCCCTGGGGCCCTTGGTGGCCACGACGGGCTGGG
GCTGCTCCGCGTGGCTGGTGACGGCGGCATCGCCTGGACCCAGGGAGAACAGGAGGTCCTCCAGCCCTTCTGCGACTTTCCAGAAATCGT
AGACATTAGCATCAAGCAGGCCCCGCGCGTTGGCCCGGCCGGAGAGCACCGCCTGGTCACTGTTACCAGGACAGACAACCAGATTTTAGA
GGCCGAGTTCCCAGGGCTGCCCGAGGCTCTGTCGTTCGTGGCGCTCGTGGACGGCTACTTCCGGCTGACCACGGACTCCCAGCACTTCTT
CTGCAAGGAGGTGGCACCGCCGAGGCTGCTGGAGGAAGTGGCCGAGCAGTGCCACGGCCCCATCACTCTGGACTTTGCCATCAACAAGCT
CAAGACTGGGGGCTCACGTCCTGGCTCCTATGTTCTCCGCCGCAGCCCCCAGGACTTTGACAGCTTCCTCCTCACTGTCTGTGTCCAGAA
CCCCCTTGGTCCTGATTATAAGGGCTGCCTCATCCGGCGCAGCCCCACAGGAACCTTCCTTCTGGTTGGCCTCAGCCGACCCCACAGCAG
TCTTCGAGAGCTCCTGGCAACCTGCTGGGATGGGGGGCTGCACGTAGATGGGGTGGCAGTGACCCTCACTTCCTGCTGTATCCCCAGACC
CAAAGAAAAGTCCAACCTGATCGTGGTCCAGAGAGGTCACAGCCCACCCACATCATCCTTGGTTCAGCCCCAATCCCAATACCAGCTGAG
TCAGATGACATTTCACAAGATCCCTGCTGACAGCCTGGAGTGGCATGAGAACCTGGGCCATGGGTCCTTCACCAAGATTTACCGGGGCTG
TCGCCATGAGGTGGTGGATGGGGAGGCCCGAAAGACAGAGGTGCTGCTGAAGGTCATGGATGCCAAGCACAAGAACTGCATGGAGTCATT
CCTGGAAGCAGCGAGCTTGATGAGCCAAGTGTCGTACCGGCATCTCGTGCTGCTCCACGGCGTGTGCATGGCTGGAGACAGCACCATGGT
GCAGGAATTTGTACACCTGGGGGCCATAGACATGTATCTGCGAAAACGTGGCCACCTGGTGCCAGCCAGCTGGAAGCTGCAGGTGGTCAA
ACAGCTGGCCTACGCCCTCAACTATCTGGAGGACAAAGGCCTGCCCCATGGCAATGTCTCTGCCCGGAAGGTGCTCCTGGCTCGGGAGGG
GGCTGATGGGAGCCCGCCCTTCATCAAGCTGAGTGACCCTGGGGTCAGCCCCGCTGTGTTAAGCCTGGAGATGCTCACCGACAGGATCCC
CTGGGTGGCCCCCGAGTGTCTCCGGGAGGCGCAGACACTTAGCTTGGAAGCTGACAAGTGGGGCTTCGGCGCCACGGTCTGGGAAGTGTT
TAGTGGCGTCACCATGCCCATCAGTGCCCTGGATCCTGCTAAGAAACTCCAATTTTATGAGGACCGGCAGCAGCTGCCGGCCCCCAAGTG
GACAGAGCTGGCCCTGCTGATTCAACAGTGCATGGCCTATGAGCCGGTCCAGAGGCCCTCCTTCCGAGCCGTCATTCGTGACCTCAATAG
CCTCATCTCTTCAGACTATGAGCTCCTCTCAGACCCCACACCTGGTGCCCTGGCACCTCGTGATGGGCTGTGGAATGGTGCCCAGCTCTA
TGCCTGCCAAGACCCCACGATCTTCGAGGAGAGACACCTCAAGTACATCTCACAGCTGGGCAAGGGCAACTTTGGCAGCGTGGAGCTGTG
CCGCTATGACCCGCTAGGCGACAATACAGGTGCCCTGGTGGCCGTGAAACAGCTGCAGCACAGCGGGCCAGACCAGCAGAGGGACTTTCA
GCGGGAGATTCAGATCCTCAAAGCACTGCACAGTGATTTCATTGTCAAGTATCGTGGTGTCAGCTATGGCCCGGGCCGCCAGAGCCTGCG
GCTGGTCATGGAGTACCTGCCCAGCGGCTGCTTGCGCGACTTCCTGCAGCGGCACCGCGCGCGCCTCGATGCCAGCCGCCTCCTTCTCTA
TTCCTCGCAGATCTGCAAGGGCATGGAGTACCTGGGCTCCCGCCGCTGCGTGCACCGCGACCTGGCCGCCCGAAACATCCTCGTGGAGAG
CGAGGCACACGTCAAGATCGCTGACTTCGGCCTAGCTAAGCTGCTGCCGCTTGACAAAGACTACTACGTGGTCCGCGAGCCAGGCCAGAG
CCCCATTTTCTGGTATGCCCCCGAATCCCTCTCGGACAACATCTTCTCTCGCCAGTCAGACGTCTGGAGCTTCGGGGTCGTCCTGTACGA
GCTCTTCACCTACTGCGACAAAAGCTGCAGCCCCTCGGCCGAGTTCCTGCGGATGATGGGATGTGAGCGGGATGTCCCCGCCCTCTGCCG
CCTCTTGGAACTGCTGGAGGAGGGCCAGAGGCTGCCGGCGCCTCCTGCCTGCCCTGCTGAGGTGAGCGCCGCAGGGCTAGCCTCAGTTTC
CCAGTCTGTAGATTGGGCCGGGGTCTCGGGCAAGCCAGCTGGCGCCTGAGTCTCTGTACTGAGAAGAAAGGCTAGAGTGTGAGGCCGATG
AGGATCCTGGCCCCCACTTGGCTACTCTCTCACTGTGTGGCAAGTCAGAGCACTTTCAGAGCCTCAGTTTACCCTTTTCCAAAATGAGAA
TAGTAATGCCTTATAGGGTGAGGGAAGATTAGACTCCTGAACACCTGTGCCTATGAGGGCTCAGCTCAAAGCCGAGCACACAGTCGATGC

>71104_71104_8_R3HDM4-JAK3_R3HDM4_chr19_913087_ENST00000587975_JAK3_chr19_17953981_ENST00000534444_length(amino acids)=950AA_BP=
MVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSL
MAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTD
NQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLT
VCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQS
QYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAG
DSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEML
TDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVI
RDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQ
QRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARN
ILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for R3HDM4-JAK3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneJAK3chr19:913086chr19:17953981ENST000004582353241_223140.01125.0cytokine/interferon/growth hormone receptors
TgeneJAK3chr19:913086chr19:17953981ENST000005276702231_223140.01125.0cytokine/interferon/growth hormone receptors
TgeneJAK3chr19:913086chr19:17953981ENST000005344443231_223140.01095.0cytokine/interferon/growth hormone receptors
TgeneJAK3chr19:913087chr19:17953981ENST000004582353241_223140.01125.0cytokine/interferon/growth hormone receptors
TgeneJAK3chr19:913087chr19:17953981ENST000005276702231_223140.01125.0cytokine/interferon/growth hormone receptors
TgeneJAK3chr19:913087chr19:17953981ENST000005344443231_223140.01095.0cytokine/interferon/growth hormone receptors


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for R3HDM4-JAK3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for R3HDM4-JAK3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC1833275Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, NK Cell-Negative6CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0085110Severe Combined Immunodeficiency2CTD_human;GENOMICS_ENGLAND
TgeneC0242583Bare Lymphocyte Syndrome2CTD_human
TgeneC0392788Nasal Type Extranodal NK/T-Cell Lymphoma2CTD_human
TgeneC1955906Lymphoma, Extranodal NK-T-Cell2CTD_human
TgeneC2700553Omenn Syndrome2CTD_human;GENOMICS_ENGLAND
TgeneC0025063Mediastinal Neoplasms1CTD_human
TgeneC0079731B-Cell Lymphomas1CTD_human
TgeneC0153504Malignant tumor of mediastinum1CTD_human
TgeneC0349639Juvenile Myelomonocytic Leukemia1CTD_human
TgeneC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
TgeneC1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
TgeneC4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human