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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANKRD44-ANKAR (FusionGDB2 ID:HG91526TG150709)

Fusion Gene Summary for ANKRD44-ANKAR

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD44-ANKAR
Fusion gene ID: hg91526tg150709
HgeneTgene
Gene symbol

ANKRD44

ANKAR

Gene ID

91526

150709

Gene nameankyrin repeat domain 44ankyrin and armadillo repeat containing
SynonymsPP6-ARS-B-
Cytomap('ANKRD44')('ANKAR')

2q33.1

2q32.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit Bankyrin repeat domain-containing protein 44serine/threonine-protein phosphatase 6 regulatory subunit ARS-Bankyrin and armadillo repeat-containing protein
Modification date2020031320200313
UniProtAcc

Q8N8A2

Q7Z5J8

Ensembl transtripts involved in fusion geneENST00000409153, ENST00000409919, 
ENST00000539527, ENST00000282272, 
ENST00000328737, ENST00000337207, 
ENST00000450567, ENST00000477852, 
Fusion gene scores* DoF score11 X 6 X 6=3964 X 4 X 3=48
# samples 114
** MAII scorelog2(11/396*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANKRD44 [Title/Abstract] AND ANKAR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANKRD44(198175302)-ANKAR(190571664), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4MESOTCGA-TS-A7P8-01AANKRD44chr2

198175302

-ANKARchr2

190571664

+


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Fusion Gene ORF analysis for ANKRD44-ANKAR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000409153ENST00000461516ANKRD44chr2

198175302

-ANKARchr2

190571664

+
5CDS-intronENST00000409919ENST00000461516ANKRD44chr2

198175302

-ANKARchr2

190571664

+
5UTR-3CDSENST00000539527ENST00000281412ANKRD44chr2

198175302

-ANKARchr2

190571664

+
5UTR-3CDSENST00000539527ENST00000313581ANKRD44chr2

198175302

-ANKARchr2

190571664

+
5UTR-3CDSENST00000539527ENST00000431575ANKRD44chr2

198175302

-ANKARchr2

190571664

+
5UTR-3CDSENST00000539527ENST00000438402ANKRD44chr2

198175302

-ANKARchr2

190571664

+
5UTR-3CDSENST00000539527ENST00000520309ANKRD44chr2

198175302

-ANKARchr2

190571664

+
5UTR-intronENST00000539527ENST00000461516ANKRD44chr2

198175302

-ANKARchr2

190571664

+
Frame-shiftENST00000409153ENST00000281412ANKRD44chr2

198175302

-ANKARchr2

190571664

+
Frame-shiftENST00000409153ENST00000313581ANKRD44chr2

198175302

-ANKARchr2

190571664

+
Frame-shiftENST00000409153ENST00000431575ANKRD44chr2

198175302

-ANKARchr2

190571664

+
Frame-shiftENST00000409153ENST00000438402ANKRD44chr2

198175302

-ANKARchr2

190571664

+
Frame-shiftENST00000409153ENST00000520309ANKRD44chr2

198175302

-ANKARchr2

190571664

+
Frame-shiftENST00000409919ENST00000281412ANKRD44chr2

198175302

-ANKARchr2

190571664

+
Frame-shiftENST00000409919ENST00000313581ANKRD44chr2

198175302

-ANKARchr2

190571664

+
Frame-shiftENST00000409919ENST00000431575ANKRD44chr2

198175302

-ANKARchr2

190571664

+
Frame-shiftENST00000409919ENST00000438402ANKRD44chr2

198175302

-ANKARchr2

190571664

+
Frame-shiftENST00000409919ENST00000520309ANKRD44chr2

198175302

-ANKARchr2

190571664

+
intron-3CDSENST00000282272ENST00000281412ANKRD44chr2

198175302

-ANKARchr2

190571664

+
intron-3CDSENST00000282272ENST00000313581ANKRD44chr2

198175302

-ANKARchr2

190571664

+
intron-3CDSENST00000282272ENST00000431575ANKRD44chr2

198175302

-ANKARchr2

190571664

+
intron-3CDSENST00000282272ENST00000438402ANKRD44chr2

198175302

-ANKARchr2

190571664

+
intron-3CDSENST00000282272ENST00000520309ANKRD44chr2

198175302

-ANKARchr2

190571664

+
intron-3CDSENST00000328737ENST00000281412ANKRD44chr2

198175302

-ANKARchr2

190571664

+
intron-3CDSENST00000328737ENST00000313581ANKRD44chr2

198175302

-ANKARchr2

190571664

+
intron-3CDSENST00000328737ENST00000431575ANKRD44chr2

198175302

-ANKARchr2

190571664

+
intron-3CDSENST00000328737ENST00000438402ANKRD44chr2

198175302

-ANKARchr2

190571664

+
intron-3CDSENST00000328737ENST00000520309ANKRD44chr2

198175302

-ANKARchr2

190571664

+
intron-3CDSENST00000337207ENST00000281412ANKRD44chr2

198175302

-ANKARchr2

190571664

+
intron-3CDSENST00000337207ENST00000313581ANKRD44chr2

198175302

-ANKARchr2

190571664

+
intron-3CDSENST00000337207ENST00000431575ANKRD44chr2

198175302

-ANKARchr2

190571664

+
intron-3CDSENST00000337207ENST00000438402ANKRD44chr2

198175302

-ANKARchr2

190571664

+
intron-3CDSENST00000337207ENST00000520309ANKRD44chr2

198175302

-ANKARchr2

190571664

+
intron-3CDSENST00000450567ENST00000281412ANKRD44chr2

198175302

-ANKARchr2

190571664

+
intron-3CDSENST00000450567ENST00000313581ANKRD44chr2

198175302

-ANKARchr2

190571664

+
intron-3CDSENST00000450567ENST00000431575ANKRD44chr2

198175302

-ANKARchr2

190571664

+
intron-3CDSENST00000450567ENST00000438402ANKRD44chr2

198175302

-ANKARchr2

190571664

+
intron-3CDSENST00000450567ENST00000520309ANKRD44chr2

198175302

-ANKARchr2

190571664

+
intron-3CDSENST00000477852ENST00000281412ANKRD44chr2

198175302

-ANKARchr2

190571664

+
intron-3CDSENST00000477852ENST00000313581ANKRD44chr2

198175302

-ANKARchr2

190571664

+
intron-3CDSENST00000477852ENST00000431575ANKRD44chr2

198175302

-ANKARchr2

190571664

+
intron-3CDSENST00000477852ENST00000438402ANKRD44chr2

198175302

-ANKARchr2

190571664

+
intron-3CDSENST00000477852ENST00000520309ANKRD44chr2

198175302

-ANKARchr2

190571664

+
intron-intronENST00000282272ENST00000461516ANKRD44chr2

198175302

-ANKARchr2

190571664

+
intron-intronENST00000328737ENST00000461516ANKRD44chr2

198175302

-ANKARchr2

190571664

+
intron-intronENST00000337207ENST00000461516ANKRD44chr2

198175302

-ANKARchr2

190571664

+
intron-intronENST00000450567ENST00000461516ANKRD44chr2

198175302

-ANKARchr2

190571664

+
intron-intronENST00000477852ENST00000461516ANKRD44chr2

198175302

-ANKARchr2

190571664

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ANKRD44-ANKAR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ANKRD44chr2198175301-ANKARchr2190571663+0.000536590.9994634
ANKRD44chr2198175301-ANKARchr2190571663+0.000536590.9994634


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ANKRD44-ANKAR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:198175302/:190571664)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKRD44

Q8N8A2

ANKAR

Q7Z5J8

FUNCTION: Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ANKRD44-ANKAR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ANKRD44-ANKAR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANKRD44-ANKAR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANKRD44-ANKAR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource