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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:AP4M1-AGAP3 (FusionGDB2 ID:HG9179TG116988)

Fusion Gene Summary for AP4M1-AGAP3

Fusion gene summary

Fusion gene information	Fusion gene name: AP4M1-AGAP3
	Fusion gene ID: hg9179tg116988
		Hgene	Tgene
	Gene symbol	AP4M1	AGAP3
	Gene ID	9179	116988
	Gene name	adaptor related protein complex 4 subunit mu 1	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
	Synonyms	CPSQ3\|MU-4\|MU-ARP2\|SPG50	AGAP-3\|CENTG3\|CRAG\|MRIP-1\|cnt-g3
	Cytomap	('AP4M1')('AGAP3') 7q22.1	7q36.1
	Type of gene	protein-coding	protein-coding
	Description	AP-4 complex subunit mu-1AP-4 adaptor complex mu subunitadapter-related protein complex 4 mu-1 subunitadapter-related protein complex 4 subunit mu-1adaptor related protein complex 4 mu 1 subunitadaptor-related protein complex AP-4 mu4 subunitmu subu	arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3CRAM-associated GTPaseCRMP (collapsin response mediator protein) associatedMR1-interacting proteincentaurin-gamma-3
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000359593, ENST00000421755, ENST00000422582, ENST00000429084, ENST00000478501,
Fusion gene scores	* DoF score	1 X 2 X 2=4	9 X 10 X 6=540
	# samples	2	10
	** MAII score	log2(2/4*10)=2.32192809488736	log2(10/540*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: AP4M1 [Title/Abstract] AND AGAP3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	AP4M1(99704137)-AGAP3(150820875), # samples:1
Anticipated loss of major functional domain due to fusion event.	AP4M1-AGAP3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AP4M1-AGAP3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AP4M1-AGAP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. AP4M1-AGAP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	AP4M1	GO:0006605	protein targeting	20230749
Hgene	AP4M1	GO:0006622	protein targeting to lysosome	11139587
Hgene	AP4M1	GO:0090160	Golgi to lysosome transport	11139587

Fusion gene breakpoints across AP4M1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across AGAP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerKB3	.	.	AP4M1	chr7	99542073	+	AGAP3	chr7	150451807	+

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Fusion Gene ORF analysis for AP4M1-AGAP3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000359593	ENST00000335367	AP4M1	chr7	99542073	+	AGAP3	chr7	150451807	+
intron-intron	ENST00000359593	ENST00000397238	AP4M1	chr7	99542073	+	AGAP3	chr7	150451807	+
intron-intron	ENST00000359593	ENST00000463381	AP4M1	chr7	99542073	+	AGAP3	chr7	150451807	+
intron-intron	ENST00000359593	ENST00000473312	AP4M1	chr7	99542073	+	AGAP3	chr7	150451807	+
intron-intron	ENST00000359593	ENST00000476375	AP4M1	chr7	99542073	+	AGAP3	chr7	150451807	+
intron-intron	ENST00000359593	ENST00000479901	AP4M1	chr7	99542073	+	AGAP3	chr7	150451807	+
intron-intron	ENST00000421755	ENST00000335367	AP4M1	chr7	99542073	+	AGAP3	chr7	150451807	+
intron-intron	ENST00000421755	ENST00000397238	AP4M1	chr7	99542073	+	AGAP3	chr7	150451807	+
intron-intron	ENST00000421755	ENST00000463381	AP4M1	chr7	99542073	+	AGAP3	chr7	150451807	+
intron-intron	ENST00000421755	ENST00000473312	AP4M1	chr7	99542073	+	AGAP3	chr7	150451807	+
intron-intron	ENST00000421755	ENST00000476375	AP4M1	chr7	99542073	+	AGAP3	chr7	150451807	+
intron-intron	ENST00000421755	ENST00000479901	AP4M1	chr7	99542073	+	AGAP3	chr7	150451807	+
intron-intron	ENST00000422582	ENST00000335367	AP4M1	chr7	99542073	+	AGAP3	chr7	150451807	+
intron-intron	ENST00000422582	ENST00000397238	AP4M1	chr7	99542073	+	AGAP3	chr7	150451807	+
intron-intron	ENST00000422582	ENST00000463381	AP4M1	chr7	99542073	+	AGAP3	chr7	150451807	+
intron-intron	ENST00000422582	ENST00000473312	AP4M1	chr7	99542073	+	AGAP3	chr7	150451807	+
intron-intron	ENST00000422582	ENST00000476375	AP4M1	chr7	99542073	+	AGAP3	chr7	150451807	+
intron-intron	ENST00000422582	ENST00000479901	AP4M1	chr7	99542073	+	AGAP3	chr7	150451807	+
intron-intron	ENST00000429084	ENST00000335367	AP4M1	chr7	99542073	+	AGAP3	chr7	150451807	+
intron-intron	ENST00000429084	ENST00000397238	AP4M1	chr7	99542073	+	AGAP3	chr7	150451807	+
intron-intron	ENST00000429084	ENST00000463381	AP4M1	chr7	99542073	+	AGAP3	chr7	150451807	+
intron-intron	ENST00000429084	ENST00000473312	AP4M1	chr7	99542073	+	AGAP3	chr7	150451807	+
intron-intron	ENST00000429084	ENST00000476375	AP4M1	chr7	99542073	+	AGAP3	chr7	150451807	+
intron-intron	ENST00000429084	ENST00000479901	AP4M1	chr7	99542073	+	AGAP3	chr7	150451807	+
intron-intron	ENST00000478501	ENST00000335367	AP4M1	chr7	99542073	+	AGAP3	chr7	150451807	+
intron-intron	ENST00000478501	ENST00000397238	AP4M1	chr7	99542073	+	AGAP3	chr7	150451807	+
intron-intron	ENST00000478501	ENST00000463381	AP4M1	chr7	99542073	+	AGAP3	chr7	150451807	+
intron-intron	ENST00000478501	ENST00000473312	AP4M1	chr7	99542073	+	AGAP3	chr7	150451807	+
intron-intron	ENST00000478501	ENST00000476375	AP4M1	chr7	99542073	+	AGAP3	chr7	150451807	+
intron-intron	ENST00000478501	ENST00000479901	AP4M1	chr7	99542073	+	AGAP3	chr7	150451807	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000429084	ENST00000463381	AP4M1	chr7	99704137	+	AGAP3	chr7	150820875	+	0.012036801	0.9879632
ENST00000359593	ENST00000463381	AP4M1	chr7	99704137	+	AGAP3	chr7	150820875	+	0.015579763	0.98442024
ENST00000421755	ENST00000463381	AP4M1	chr7	99704137	+	AGAP3	chr7	150820875	+	0.018683081	0.9813169
ENST00000422582	ENST00000463381	AP4M1	chr7	99704137	+	AGAP3	chr7	150820875	+	0.022423401	0.97757655

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Fusion Genomic Features for AP4M1-AGAP3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
AP4M1	chr7	99704137	+	AGAP3	chr7	150820880	+	0.00026333	0.9997366
AP4M1	chr7	99704137	+	AGAP3	chr7	150820880	+	0.00026333	0.9997366

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AP4M1-AGAP3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:99704137/chr7:150820875)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

AGAP3

chr7:99704137

chr7:150820875

ENST00000397238

626_746

376

912.0

Domain

Arf-GAP

Tgene

AGAP3

chr7:99704137

chr7:150820875

ENST00000397238

748_777

376

912.0

Repeat

Note=ANK 1

Tgene

AGAP3

chr7:99704137

chr7:150820875

ENST00000397238

785_814

376

912.0

Repeat

Note=ANK 2

Tgene

AGAP3

chr7:99704137

chr7:150820875

ENST00000397238

818_847

376

912.0

Repeat

Note=ANK 3

Tgene

AGAP3

chr7:99704137

chr7:150820875

ENST00000397238

641_664

376

912.0

Zinc finger

C4-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

AP4M1

chr7:99704137

chr7:150820875

ENST00000359593

184_452

379

454.0

Domain

MHD

Hgene

AP4M1

chr7:99704137

chr7:150820875

ENST00000421755

184_452

379

460.6666666666667

Domain

MHD

Tgene

AGAP3

chr7:99704137

chr7:150820875

ENST00000397238

367_605

376

912.0

Domain

Tgene

AGAP3

chr7:99704137

chr7:150820875

ENST00000397238

142_146

376

912.0

Nucleotide binding

GTP

Tgene

AGAP3

chr7:99704137

chr7:150820875

ENST00000397238

198_201

376

912.0

Nucleotide binding

GTP

Tgene

AGAP3

chr7:99704137

chr7:150820875

ENST00000397238

98_105

376

912.0

Nucleotide binding

GTP

Tgene

AGAP3

chr7:99704137

chr7:150820875

ENST00000397238

84_375

376

912.0

Region

Note=Small GTPase-like

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Fusion Gene Sequence for AP4M1-AGAP3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>5309_5309_1_AP4M1-AGAP3_AP4M1_chr7_99704137_ENST00000359593_AGAP3_chr7_150820875_ENST00000463381_length(transcript)=3085nt_BP=1295nt
GGGGTAGTGCAGGCGCCGGGTTTCCCGCGGTCCGAGCTGGCGCGGGCGGAGGAGAATCGCTCTTAAAGGGCCAGCGCACACGCGTTCTTT
TGTTCCGGGGCCGCAGGGCGGGGCAGGCCCGACTTTCGCCGTCTTCTTGTCTACTCTCCAGAACGGCCATGATTTCCCAATTCTTCATTC
TGTCCTCCAAGGGGGACCCGCTCATCTACAAAGACTTCCGCGGGGACAGTGGCGGCCGGGATGTGGCCGAGCTCTTCTACCGGAAGCTGA
CGGGACTGCCAGGAGACGAGTCCCCGGTTGTCATGCATCACCATGGCCGTCATTTCATTCACATCAGACACAGCGGCCTCTATTTGGTGG
TCACAACTTCAGAAAACGTTTCTCCCTTCAGCCTCCTAGAACTGCTCTCCAGGTTGGCCACCCTTCTGGGCGATTACTGTGGCTCCCTGG
GCGAGGGGACCATCTCCCGCAATGTGGCTCTGGTATACGAACTCCTGGATGAAGTGCTGGACTATGGCTATGTACAGACCACATCCACGG
AGATGCTGAGGAATTTCATCCAGACGGAAGCTGTGGTCAGCAAGCCCTTCAGCCTCTTTGACCTCAGCAGCGTTGGCTTGTTTGGGGCTG
AGACACAACAGAGCAAAGTGGCCCCCAGCAGTGCAGCCAGCCGCCCCGTCCTGTCCAGTCGCTCTGACCAGAGCCAAAAGAATGAAGTTT
TTTTGGATGTGGTCGAGAGATTGTCTGTACTGATAGCATCTAATGGATCCCTGCTGAAGGTGGATGTGCAGGGAGAGATTCGGCTCAAGA
GCTTCCTTCCTAGCGGCTCTGAGATGCGCATTGGCTTGACGGAAGAGTTTTGTGTGGGGAAGTCAGAGCTGAGAGGTTATGGGCCAGGAA
TCCGGGTCGATGAAGTCTCGTTTCACAGCTCTGTGAATCTGGACGAATTTGAGTCTCATCGAATCCTCCGCTTGCAACCACCTCAGGGCG
AGCTGACTGTGATGCGGTACCAACTCTCCGATGACCTCCCCTCACCGCTCCCCTTCCGGCTCTTCCCCTCTGTGCAGTGGGACCGAGGCT
CAGGCCGGCTCCAGGTTTATCTAAAGTTGCGATGTGACCTGCTCTCAAAGAGCCAAGCCCTCAATGTCAGGCTGCACCTCCCCCTGCCTC
GAGGGGTGGTCAGCCTGTCTCAGGAGCTGAGCAGCCCAGAGCAGAAGGCTGAGCTGGCAGAGGGAGCCCTTCGCTGGGACCTGCCTCGGG
TGCAAGGAGGCTCTCAACTCTCAGGCCTTTTCCAGTCTCGGAAGGGTGCTGACCTGGACCGGGAGAAGAAGGCTGCCGAGTGCAAGGTGG
ACAGCATCGGGAGCGGCCGCGCCATCCCCATCAAGCAGGGGATCCTGCTAAAGCGGAGCGGCAAGTCCCTGAACAAGGAGTGGAAGAAGA
AGTATGTGACGCTCTGTGACAACGGGCTGCTCACCTATCACCCCAGCCTGCATGATTACATGCAGAACATCCACGGCAAGGAGATTGACC
TGCTGCGGACAACGGTGAAAGTGCCAGGGAAGCGCCTGCCCCGAGCCACACCTGCCACAGCCCCGGGCACCAGCCCCCGTGCCAACGGGC
TGTCCGTGGAGCGGAGTAACACACAGCTGGGTGGGGGCACAGAGGCAGAGGAGTCGTTTGAATTTGTGGTGGTGTCCCTCACTGGGCAGA
CGTGGCACTTCGAGGCTTCAACGGCGGAGGAGCGGGAGCTGTGGGTTCAGAGTGTGCAGGCCCAGATCCTTGCCAGCCTGCAAGGCTGCC
GCAGTGCCAAGGACAAGACTCGACTGGGGAACCAGAACGCAGCTCTGGCTGTGCAGGCCGTCCGCACCGTCCGCGGCAACAGCTTTTGTA
TCGACTGCGATGCACCCAATCCAGACTGGGCCAGCCTGAACCTGGGTGCCCTGATGTGCATTGAGTGCTCAGGCATCCACCGACACCTGG
GGGCTCACCTGTCCCGGGTGCGCTCCCTTGACCTCGATGACTGGCCGCCTGAGCTGCTGGCTGTCATGACTGCCATGGGCAATGCCCTCG
CCAACAGCGTCTGGGAGGGGGCCTTGGGTGGCTACTCCAAGCCAGGGCCTGATGCCTGCAGAGAGGAGAAGGAACGCTGGATACGGGCCA
AGTATGAACAGAAGCTCTTCCTGGCCCCACTGCCAAGCTCAGATGTGCCACTGGGGCAGCAGCTGCTCCGGGCCGTGGTGGAAGATGACC
TGCGGCTGTTGGTGATGCTCCTGGCACATGGCTCCAAAGAGGAGGTGAATGAGACCTATGGGGACGGGGACGGGCGGACGGCTCTACATC
TCTCCAGTGCCATGGCCAACGTTGTCTTCACGCAGCTGCTCATCTGGTACGGGGTGGACGTGAGGAGCCGGGACGCCCGGGGCCTGACTC
CACTGGCATATGCTCGCCGGGCCGGCAGCCAGGAGTGTGCAGACATCTTGATCCAGCATGGCTGCCCTGGGGAGGGCTGTGGCTTAGCGC
CTACCCCCAACAGAGAGCCTGCCAATGGCACCAACCCCTCTGCTGAGCTGCACCGTAGTCCTAGCCTCCTATAAGGCCCAGGAAGAGGGC
AGAGGGGCCAGAAGGACTCCATGGCCCAAAGACCCTCCTCCCTGCAGGCACTGTGGGAACAGACACAGAGATGGAGAAGCAGGGACATGC
TGAGAGGACGAAGCCAAGGAAATTAGGGAGGAGAGTCAAAGGGATCAAGGAGAGTTGGGGATTTGAGCTGCAGCAGAGAGGGATGAGGGA
TTTAGCCCTCTGCCCTAAGGTGCCATTGAAAAGGGACAGGACCCTTCGGAGGTGCCTGTGAGGAGAGGGGAGCAGGACCTCTCCCTCCTC
CAGATCCCTGCCTCCTAGTGCCAGCCCCTCACACGCCTTCATCCTGAAACAGGAAGAGGACGGCACCAAGTTGGGGGTGCTGGATGAAAG
AGACGAGGGGTGATCTGTGAGTCCCATGTAAACTTTGTACATTGGAATATTTATGTTTGTGTACATATTTGATGTGTGTGTGTATGATGA

>5309_5309_1_AP4M1-AGAP3_AP4M1_chr7_99704137_ENST00000359593_AGAP3_chr7_150820875_ENST00000463381_length(amino acids)=834AA_BP=399
MFRGRRAGQARLSPSSCLLSRTAMISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVMHHHGRHFIHIRHSGLYLV
VTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVLDYGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGA
ETQQSKVAPSSAASRPVLSSRSDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEEFCVGKSELRGYGPG
IRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSPLPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLP
RGVVSLSQELSSPEQKAELAEGALRWDLPRVQGGSQLSGLFQSRKGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNKEWKK
KYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPATAPGTSPRANGLSVERSNTQLGGGTEAEESFEFVVVSLTGQ
TWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQNAALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHL
GAHLSRVRSLDLDDWPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLAPLPSSDVPLGQQLLRAVVEDD
LRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGEGCGLA

--------------------------------------------------------------
>5309_5309_2_AP4M1-AGAP3_AP4M1_chr7_99704137_ENST00000421755_AGAP3_chr7_150820875_ENST00000463381_length(transcript)=2978nt_BP=1188nt
GCGGGGCAGGCCCGACTTTCGCCGTCTTCTTGTCTACTCTCCAGAACGGCCATGATTTCCCAATTCTTCATTCTGTCCTCCAAGGGGGAC
CCGCTCATCTACAAAGACTTCCGCGGGGACAGTGGCGGCCGGGATGTGGCCGAGCTCTTCTACCGGAAGCTGACGGGACTGCCAGGAGAC
GAGTCCCCGGTTGTCATGCATCACCATGGCCGTCATTTCATTCACATCAGACACAGCGGCCTCTATTTGGTGGTCACAACTTCAGAAAAC
GTTTCTCCCTTCAGCCTCCTAGAACTGCTCTCCAGGTTGGCCACCCTTCTGGGCGATTACTGTGGCTCCCTGGGCGAGGGGACCATCTCC
CGCAATGTGGCTCTGGTATACGAACTCCTGGATGAAGTGCTGGACTATGGCTATGTACAGACCACATCCACGGAGATGCTGAGGAATTTC
ATCCAGACGGAAGCTGTGGTCAGCAAGCCCTTCAGCCTCTTTGACCTCAGCAGCGTTGGCTTGTTTGGGGCTGAGACACAACAGAGCAAA
GTGGCCCCCAGCAGTGCAGCCAGCCGCCCCGTCCTGTCCAGTCGCTCTGACCAGAGCCAAAAGAATGAAGTTTTTTTGGATGTGGTCGAG
AGATTGTCTGTACTGATAGCATCTAATGGATCCCTGCTGAAGGTGGATGTGCAGGGAGAGATTCGGCTCAAGAGCTTCCTTCCTAGCGGC
TCTGAGATGCGCATTGGCTTGACGGAAGAGTTTTGTGTGGGGAAGTCAGAGCTGAGAGGTTATGGGCCAGGAATCCGGGTCGATGAAGTC
TCGTTTCACAGCTCTGTGAATCTGGACGAATTTGAGTCTCATCGAATCCTCCGCTTGCAACCACCTCAGGGCGAGCTGACTGTGATGCGG
TACCAACTCTCCGATGACCTCCCCTCACCGCTCCCCTTCCGGCTCTTCCCCTCTGTGCAGTGGGACCGAGGCTCAGGCCGGCTCCAGGTT
TATCTAAAGTTGCGATGTGACCTGCTCTCAAAGAGCCAAGCCCTCAATGTCAGGCTGCACCTCCCCCTGCCTCGAGGGGTGGTCAGCCTG
TCTCAGGAGCTGAGCAGCCCAGAGCAGAAGGCTGAGCTGGCAGAGGGAGCCCTTCGCTGGGACCTGCCTCGGGTGCAAGGAGGCTCTCAA
CTCTCAGGCCTTTTCCAGTCTCGGAAGGGTGCTGACCTGGACCGGGAGAAGAAGGCTGCCGAGTGCAAGGTGGACAGCATCGGGAGCGGC
CGCGCCATCCCCATCAAGCAGGGGATCCTGCTAAAGCGGAGCGGCAAGTCCCTGAACAAGGAGTGGAAGAAGAAGTATGTGACGCTCTGT
GACAACGGGCTGCTCACCTATCACCCCAGCCTGCATGATTACATGCAGAACATCCACGGCAAGGAGATTGACCTGCTGCGGACAACGGTG
AAAGTGCCAGGGAAGCGCCTGCCCCGAGCCACACCTGCCACAGCCCCGGGCACCAGCCCCCGTGCCAACGGGCTGTCCGTGGAGCGGAGT
AACACACAGCTGGGTGGGGGCACAGAGGCAGAGGAGTCGTTTGAATTTGTGGTGGTGTCCCTCACTGGGCAGACGTGGCACTTCGAGGCT
TCAACGGCGGAGGAGCGGGAGCTGTGGGTTCAGAGTGTGCAGGCCCAGATCCTTGCCAGCCTGCAAGGCTGCCGCAGTGCCAAGGACAAG
ACTCGACTGGGGAACCAGAACGCAGCTCTGGCTGTGCAGGCCGTCCGCACCGTCCGCGGCAACAGCTTTTGTATCGACTGCGATGCACCC
AATCCAGACTGGGCCAGCCTGAACCTGGGTGCCCTGATGTGCATTGAGTGCTCAGGCATCCACCGACACCTGGGGGCTCACCTGTCCCGG
GTGCGCTCCCTTGACCTCGATGACTGGCCGCCTGAGCTGCTGGCTGTCATGACTGCCATGGGCAATGCCCTCGCCAACAGCGTCTGGGAG
GGGGCCTTGGGTGGCTACTCCAAGCCAGGGCCTGATGCCTGCAGAGAGGAGAAGGAACGCTGGATACGGGCCAAGTATGAACAGAAGCTC
TTCCTGGCCCCACTGCCAAGCTCAGATGTGCCACTGGGGCAGCAGCTGCTCCGGGCCGTGGTGGAAGATGACCTGCGGCTGTTGGTGATG
CTCCTGGCACATGGCTCCAAAGAGGAGGTGAATGAGACCTATGGGGACGGGGACGGGCGGACGGCTCTACATCTCTCCAGTGCCATGGCC
AACGTTGTCTTCACGCAGCTGCTCATCTGGTACGGGGTGGACGTGAGGAGCCGGGACGCCCGGGGCCTGACTCCACTGGCATATGCTCGC
CGGGCCGGCAGCCAGGAGTGTGCAGACATCTTGATCCAGCATGGCTGCCCTGGGGAGGGCTGTGGCTTAGCGCCTACCCCCAACAGAGAG
CCTGCCAATGGCACCAACCCCTCTGCTGAGCTGCACCGTAGTCCTAGCCTCCTATAAGGCCCAGGAAGAGGGCAGAGGGGCCAGAAGGAC
TCCATGGCCCAAAGACCCTCCTCCCTGCAGGCACTGTGGGAACAGACACAGAGATGGAGAAGCAGGGACATGCTGAGAGGACGAAGCCAA
GGAAATTAGGGAGGAGAGTCAAAGGGATCAAGGAGAGTTGGGGATTTGAGCTGCAGCAGAGAGGGATGAGGGATTTAGCCCTCTGCCCTA
AGGTGCCATTGAAAAGGGACAGGACCCTTCGGAGGTGCCTGTGAGGAGAGGGGAGCAGGACCTCTCCCTCCTCCAGATCCCTGCCTCCTA
GTGCCAGCCCCTCACACGCCTTCATCCTGAAACAGGAAGAGGACGGCACCAAGTTGGGGGTGCTGGATGAAAGAGACGAGGGGTGATCTG
TGAGTCCCATGTAAACTTTGTACATTGGAATATTTATGTTTGTGTACATATTTGATGTGTGTGTGTATGATGAGCCAATAAACCAGACTG

>5309_5309_2_AP4M1-AGAP3_AP4M1_chr7_99704137_ENST00000421755_AGAP3_chr7_150820875_ENST00000463381_length(amino acids)=811AA_BP=376
MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVMHHHGRHFIHIRHSGLYLVVTTSENVSPFSLLELLSRLATLL
GDYCGSLGEGTISRNVALVYELLDEVLDYGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRPVLSSRSD
QSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEEFCVGKSELRGYGPGIRVDEVSFHSSVNLDEFESHRIL
RLQPPQGELTVMRYQLSDDLPSPLPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQKAELAEGA
LRWDLPRVQGGSQLSGLFQSRKGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNKEWKKKYVTLCDNGLLTYHPSLHDYMQN
IHGKEIDLLRTTVKVPGKRLPRATPATAPGTSPRANGLSVERSNTQLGGGTEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQI
LASLQGCRSAKDKTRLGNQNAALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAVM
TAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLAPLPSSDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDG
DGRTALHLSSAMANVVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGEGCGLAPTPNREPANGTNPSAELHRSPSL

--------------------------------------------------------------
>5309_5309_3_AP4M1-AGAP3_AP4M1_chr7_99704137_ENST00000422582_AGAP3_chr7_150820875_ENST00000463381_length(transcript)=3113nt_BP=1323nt
ACTTGGGGGGTGCATTCCGCCAAATAAAGCTAACGTGAGGCCCGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGACCGAGG
CGGGCGGATCACCTGAGGTCAGGAGTTCGAAATCAGCCTGGCCAACATGGTGAAACTCCGCCTCTACTAAAAATACAAAAAAAAAAAAAA
CATAGCTGGGCGTGGTGGCGGGCGCCTGTAATCCCATCTACTCGGGAAGCTGAGGCTTGAGAATCGCTTGAATCCAAGAGGCAGAGGTTG
CAGTGAGCCGAGATCCGGACACCGCACTCCAGCCTGGGAGACAGAGCGAGACTCCCTCTCGGGCATCACCATGGCCGTCATTTCATTCAC
ATCAGACACAGCGGCCTCTATTTGGTGGTCACAACTTCAGAAAACGTTTCTCCCTTCAGCCTCCTAGAACTGCTCTCCAGGTTGGCCACC
CTTCTGGGCGATTACTGTGGCTCCCTGGGCGAGGGGACCATCTCCCGCAATGTGGCTCTGGTATACGAACTCCTGGATGAAGTGCTGGAC
TATGGCTATGTACAGACCACATCCACGGAGATGCTGAGGAATTTCATCCAGACGGAAGCTGTGGTCAGCAAGCCCTTCAGCCTCTTTGAC
CTCAGCAGCGTTGGCTTGTTTGGGGCTGAGACACAACAGAGCAAAGTGGCCCCCAGCAGTGCAGCCAGCCGCCCCGTCCTGTCCAGTCGC
TCTGACCAGAGCCAAAAGAATGAAGTTTTTTTGGATGTGGTCGAGAGATTGTCTGTACTGATAGCATCTAATGGATCCCTGCTGAAGGTG
GATGTGCAGGGAGAGATTCGGCTCAAGAGCTTCCTTCCTAGCGGCTCTGAGATGCGCATTGGCTTGACGGAAGAGTTTTGTGTGGGGAAG
TCAGAGCTGAGAGGTTATGGGCCAGGAATCCGGGTCGATGAAGTCTCGTTTCACAGCTCTGTGAATCTGGACGAATTTGAGTCTCATCGA
ATCCTCCGCTTGCAACCACCTCAGGGCGAGCTGACTGTGATGCGGTACCAACTCTCCGATGACCTCCCCTCACCGCTCCCCTTCCGGCTC
TTCCCCTCTGTGCAGTGGGACCGAGGCTCAGGCCGGCTCCAGGTTTATCTAAAGTTGCGATGTGACCTGCTCTCAAAGAGCCAAGCCCTC
AATGTCAGGCTGCACCTCCCCCTGCCTCGAGGGGTGGTCAGCCTGTCTCAGGAGCTGAGCAGCCCAGAGCAGAAGGCTGAGCTGGCAGAG
GGAGCCCTTCGCTGGGACCTGCCTCGGGTGCAAGGAGGCTCTCAACTCTCAGGCCTTTTCCAGTCTCGGAAGGGTGCTGACCTGGACCGG
GAGAAGAAGGCTGCCGAGTGCAAGGTGGACAGCATCGGGAGCGGCCGCGCCATCCCCATCAAGCAGGGGATCCTGCTAAAGCGGAGCGGC
AAGTCCCTGAACAAGGAGTGGAAGAAGAAGTATGTGACGCTCTGTGACAACGGGCTGCTCACCTATCACCCCAGCCTGCATGATTACATG
CAGAACATCCACGGCAAGGAGATTGACCTGCTGCGGACAACGGTGAAAGTGCCAGGGAAGCGCCTGCCCCGAGCCACACCTGCCACAGCC
CCGGGCACCAGCCCCCGTGCCAACGGGCTGTCCGTGGAGCGGAGTAACACACAGCTGGGTGGGGGCACAGAGGCAGAGGAGTCGTTTGAA
TTTGTGGTGGTGTCCCTCACTGGGCAGACGTGGCACTTCGAGGCTTCAACGGCGGAGGAGCGGGAGCTGTGGGTTCAGAGTGTGCAGGCC
CAGATCCTTGCCAGCCTGCAAGGCTGCCGCAGTGCCAAGGACAAGACTCGACTGGGGAACCAGAACGCAGCTCTGGCTGTGCAGGCCGTC
CGCACCGTCCGCGGCAACAGCTTTTGTATCGACTGCGATGCACCCAATCCAGACTGGGCCAGCCTGAACCTGGGTGCCCTGATGTGCATT
GAGTGCTCAGGCATCCACCGACACCTGGGGGCTCACCTGTCCCGGGTGCGCTCCCTTGACCTCGATGACTGGCCGCCTGAGCTGCTGGCT
GTCATGACTGCCATGGGCAATGCCCTCGCCAACAGCGTCTGGGAGGGGGCCTTGGGTGGCTACTCCAAGCCAGGGCCTGATGCCTGCAGA
GAGGAGAAGGAACGCTGGATACGGGCCAAGTATGAACAGAAGCTCTTCCTGGCCCCACTGCCAAGCTCAGATGTGCCACTGGGGCAGCAG
CTGCTCCGGGCCGTGGTGGAAGATGACCTGCGGCTGTTGGTGATGCTCCTGGCACATGGCTCCAAAGAGGAGGTGAATGAGACCTATGGG
GACGGGGACGGGCGGACGGCTCTACATCTCTCCAGTGCCATGGCCAACGTTGTCTTCACGCAGCTGCTCATCTGGTACGGGGTGGACGTG
AGGAGCCGGGACGCCCGGGGCCTGACTCCACTGGCATATGCTCGCCGGGCCGGCAGCCAGGAGTGTGCAGACATCTTGATCCAGCATGGC
TGCCCTGGGGAGGGCTGTGGCTTAGCGCCTACCCCCAACAGAGAGCCTGCCAATGGCACCAACCCCTCTGCTGAGCTGCACCGTAGTCCT
AGCCTCCTATAAGGCCCAGGAAGAGGGCAGAGGGGCCAGAAGGACTCCATGGCCCAAAGACCCTCCTCCCTGCAGGCACTGTGGGAACAG
ACACAGAGATGGAGAAGCAGGGACATGCTGAGAGGACGAAGCCAAGGAAATTAGGGAGGAGAGTCAAAGGGATCAAGGAGAGTTGGGGAT
TTGAGCTGCAGCAGAGAGGGATGAGGGATTTAGCCCTCTGCCCTAAGGTGCCATTGAAAAGGGACAGGACCCTTCGGAGGTGCCTGTGAG
GAGAGGGGAGCAGGACCTCTCCCTCCTCCAGATCCCTGCCTCCTAGTGCCAGCCCCTCACACGCCTTCATCCTGAAACAGGAAGAGGACG
GCACCAAGTTGGGGGTGCTGGATGAAAGAGACGAGGGGTGATCTGTGAGTCCCATGTAAACTTTGTACATTGGAATATTTATGTTTGTGT

>5309_5309_3_AP4M1-AGAP3_AP4M1_chr7_99704137_ENST00000422582_AGAP3_chr7_150820875_ENST00000463381_length(amino acids)=772AA_BP=337
MGDRARLPLGHHHGRHFIHIRHSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVLDYGYVQTTSTEM
LRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRPVLSSRSDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSF
LPSGSEMRIGLTEEFCVGKSELRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSPLPFRLFPSVQWDRGSG
RLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQKAELAEGALRWDLPRVQGGSQLSGLFQSRKGADLDREKKAAECKVDS
IGSGRAIPIKQGILLKRSGKSLNKEWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPATAPGTSPRANGLS
VERSNTQLGGGTEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQNAALAVQAVRTVRGNSFCID
CDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKY
EQKLFLAPLPSSDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDVRSRDARGLTPL

--------------------------------------------------------------
>5309_5309_4_AP4M1-AGAP3_AP4M1_chr7_99704137_ENST00000429084_AGAP3_chr7_150820875_ENST00000463381_length(transcript)=3106nt_BP=1316nt
GGGGTAGTGCAGGCGCCGGGTTTCCCGCGGTCCGAGCTGGCGCGGGCGGAGGAGAATCGCTCTTAAAGGGCCAGCGCACACGCGTTCTTT
TGTTCCGGGGCCGCAGGGCGGGGCAGGCCCGACTTTCGCCGTCTTCTTGTCTACTCTCCAGAACGGCCATGATTTCCCAATTCTTCATTC
TGTCCTCCAAGGGGGACCCGCTCATCTACAAAGACTTCCGCGGGGACAGTGGCGGCCGGGATGTGGCCGAGCTCTTCTACCGGAAGCTGA
CGGGACTGCCAGGAGACGAGTCCCCGGTTGTCATGGTAACCAGTGGCGGGAGGCGGCATCACCATGGCCGTCATTTCATTCACATCAGAC
ACAGCGGCCTCTATTTGGTGGTCACAACTTCAGAAAACGTTTCTCCCTTCAGCCTCCTAGAACTGCTCTCCAGGTTGGCCACCCTTCTGG
GCGATTACTGTGGCTCCCTGGGCGAGGGGACCATCTCCCGCAATGTGGCTCTGGTATACGAACTCCTGGATGAAGTGCTGGACTATGGCT
ATGTACAGACCACATCCACGGAGATGCTGAGGAATTTCATCCAGACGGAAGCTGTGGTCAGCAAGCCCTTCAGCCTCTTTGACCTCAGCA
GCGTTGGCTTGTTTGGGGCTGAGACACAACAGAGCAAAGTGGCCCCCAGCAGTGCAGCCAGCCGCCCCGTCCTGTCCAGTCGCTCTGACC
AGAGCCAAAAGAATGAAGTTTTTTTGGATGTGGTCGAGAGATTGTCTGTACTGATAGCATCTAATGGATCCCTGCTGAAGGTGGATGTGC
AGGGAGAGATTCGGCTCAAGAGCTTCCTTCCTAGCGGCTCTGAGATGCGCATTGGCTTGACGGAAGAGTTTTGTGTGGGGAAGTCAGAGC
TGAGAGGTTATGGGCCAGGAATCCGGGTCGATGAAGTCTCGTTTCACAGCTCTGTGAATCTGGACGAATTTGAGTCTCATCGAATCCTCC
GCTTGCAACCACCTCAGGGCGAGCTGACTGTGATGCGGTACCAACTCTCCGATGACCTCCCCTCACCGCTCCCCTTCCGGCTCTTCCCCT
CTGTGCAGTGGGACCGAGGCTCAGGCCGGCTCCAGGTTTATCTAAAGTTGCGATGTGACCTGCTCTCAAAGAGCCAAGCCCTCAATGTCA
GGCTGCACCTCCCCCTGCCTCGAGGGGTGGTCAGCCTGTCTCAGGAGCTGAGCAGCCCAGAGCAGAAGGCTGAGCTGGCAGAGGGAGCCC
TTCGCTGGGACCTGCCTCGGGTGCAAGGAGGCTCTCAACTCTCAGGCCTTTTCCAGTCTCGGAAGGGTGCTGACCTGGACCGGGAGAAGA
AGGCTGCCGAGTGCAAGGTGGACAGCATCGGGAGCGGCCGCGCCATCCCCATCAAGCAGGGGATCCTGCTAAAGCGGAGCGGCAAGTCCC
TGAACAAGGAGTGGAAGAAGAAGTATGTGACGCTCTGTGACAACGGGCTGCTCACCTATCACCCCAGCCTGCATGATTACATGCAGAACA
TCCACGGCAAGGAGATTGACCTGCTGCGGACAACGGTGAAAGTGCCAGGGAAGCGCCTGCCCCGAGCCACACCTGCCACAGCCCCGGGCA
CCAGCCCCCGTGCCAACGGGCTGTCCGTGGAGCGGAGTAACACACAGCTGGGTGGGGGCACAGAGGCAGAGGAGTCGTTTGAATTTGTGG
TGGTGTCCCTCACTGGGCAGACGTGGCACTTCGAGGCTTCAACGGCGGAGGAGCGGGAGCTGTGGGTTCAGAGTGTGCAGGCCCAGATCC
TTGCCAGCCTGCAAGGCTGCCGCAGTGCCAAGGACAAGACTCGACTGGGGAACCAGAACGCAGCTCTGGCTGTGCAGGCCGTCCGCACCG
TCCGCGGCAACAGCTTTTGTATCGACTGCGATGCACCCAATCCAGACTGGGCCAGCCTGAACCTGGGTGCCCTGATGTGCATTGAGTGCT
CAGGCATCCACCGACACCTGGGGGCTCACCTGTCCCGGGTGCGCTCCCTTGACCTCGATGACTGGCCGCCTGAGCTGCTGGCTGTCATGA
CTGCCATGGGCAATGCCCTCGCCAACAGCGTCTGGGAGGGGGCCTTGGGTGGCTACTCCAAGCCAGGGCCTGATGCCTGCAGAGAGGAGA
AGGAACGCTGGATACGGGCCAAGTATGAACAGAAGCTCTTCCTGGCCCCACTGCCAAGCTCAGATGTGCCACTGGGGCAGCAGCTGCTCC
GGGCCGTGGTGGAAGATGACCTGCGGCTGTTGGTGATGCTCCTGGCACATGGCTCCAAAGAGGAGGTGAATGAGACCTATGGGGACGGGG
ACGGGCGGACGGCTCTACATCTCTCCAGTGCCATGGCCAACGTTGTCTTCACGCAGCTGCTCATCTGGTACGGGGTGGACGTGAGGAGCC
GGGACGCCCGGGGCCTGACTCCACTGGCATATGCTCGCCGGGCCGGCAGCCAGGAGTGTGCAGACATCTTGATCCAGCATGGCTGCCCTG
GGGAGGGCTGTGGCTTAGCGCCTACCCCCAACAGAGAGCCTGCCAATGGCACCAACCCCTCTGCTGAGCTGCACCGTAGTCCTAGCCTCC
TATAAGGCCCAGGAAGAGGGCAGAGGGGCCAGAAGGACTCCATGGCCCAAAGACCCTCCTCCCTGCAGGCACTGTGGGAACAGACACAGA
GATGGAGAAGCAGGGACATGCTGAGAGGACGAAGCCAAGGAAATTAGGGAGGAGAGTCAAAGGGATCAAGGAGAGTTGGGGATTTGAGCT
GCAGCAGAGAGGGATGAGGGATTTAGCCCTCTGCCCTAAGGTGCCATTGAAAAGGGACAGGACCCTTCGGAGGTGCCTGTGAGGAGAGGG
GAGCAGGACCTCTCCCTCCTCCAGATCCCTGCCTCCTAGTGCCAGCCCCTCACACGCCTTCATCCTGAAACAGGAAGAGGACGGCACCAA
GTTGGGGGTGCTGGATGAAAGAGACGAGGGGTGATCTGTGAGTCCCATGTAAACTTTGTACATTGGAATATTTATGTTTGTGTACATATT

>5309_5309_4_AP4M1-AGAP3_AP4M1_chr7_99704137_ENST00000429084_AGAP3_chr7_150820875_ENST00000463381_length(amino acids)=841AA_BP=406
MFRGRRAGQARLSPSSCLLSRTAMISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVMVTSGGRRHHHGRHFIHIR
HSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVLDYGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLS
SVGLFGAETQQSKVAPSSAASRPVLSSRSDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEEFCVGKSE
LRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSPLPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNV
RLHLPLPRGVVSLSQELSSPEQKAELAEGALRWDLPRVQGGSQLSGLFQSRKGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKS
LNKEWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPATAPGTSPRANGLSVERSNTQLGGGTEAEESFEFV
VVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQNAALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIEC
SGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLAPLPSSDVPLGQQLL
RAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AP4M1-AGAP3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for AP4M1-AGAP3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for AP4M1-AGAP3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	AP4M1	C2752008	Spastic Paraplegia-50, Autosomal Recessive	2	CTD_human;GENOMICS_ENGLAND
Hgene	AP4M1	C0020796	Profound Mental Retardation	1	CTD_human
Hgene	AP4M1	C0025363	Mental Retardation, Psychosocial	1	CTD_human
Hgene	AP4M1	C0917816	Mental deficiency	1	CTD_human
Hgene	AP4M1	C3714756	Intellectual Disability	1	CTD_human
Hgene	AP4M1	C4755264	Severe intellectual disability and progressive spastic paraplegia	1	ORPHANET

Fusion Gene Studies in Kim Lab

Fusion gene:AP4M1-AGAP3 (FusionGDB2 ID:HG9179TG116988)

Fusion Gene Summary for AP4M1-AGAP3

Fusion Gene ORF analysis for AP4M1-AGAP3

Fusion Genomic Features for AP4M1-AGAP3

Fusion Protein Features for AP4M1-AGAP3

Fusion Gene Sequence for AP4M1-AGAP3

Fusion Gene PPI Analysis for AP4M1-AGAP3

Related Drugs for AP4M1-AGAP3

Related Diseases for AP4M1-AGAP3

Fusion Gene Studies
in Kim Lab