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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DLGAP1-LRRC23 (FusionGDB2 ID:HG9229TG10233)

Fusion Gene Summary for DLGAP1-LRRC23

check button Fusion gene summary
Fusion gene informationFusion gene name: DLGAP1-LRRC23
Fusion gene ID: hg9229tg10233
HgeneTgene
Gene symbol

DLGAP1

LRRC23

Gene ID

9229

10233

Gene nameDLG associated protein 1leucine rich repeat containing 23
SynonymsDAP-1|DAP-1-ALPHA|DAP-1-BETA|DAP1|DLGAP1A|DLGAP1B|GKAP|SAPAP1LRPB7
Cytomap('DLGAP1')('LRRC23')

18p11.31

12p13.31

Type of geneprotein-codingprotein-coding
Descriptiondisks large-associated protein 1PSD-95/SAP90 binding protein 1SAP90/PSD-95-associated protein 1discs large homolog associated protein 1guanylate kinase-associated proteinleucine-rich repeat-containing protein 23leucine-rich protein B7
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000315677, ENST00000581527, 
ENST00000400145, ENST00000400147, 
ENST00000400149, ENST00000400150, 
ENST00000400155, ENST00000478161, 
ENST00000515196, ENST00000534970, 
ENST00000539435, ENST00000581699, 
ENST00000584874, 
Fusion gene scores* DoF score37 X 27 X 8=79927 X 7 X 7=343
# samples 3710
** MAII scorelog2(37/7992*10)=-4.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/343*10)=-1.77820857639809
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DLGAP1 [Title/Abstract] AND LRRC23 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDLGAP1(4455006)-LRRC23(6992868), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-63-A5MP-01ADLGAP1chr18

4455006

-LRRC23chr12

6992868

+
ChimerDB4LUSCTCGA-63-A5MPDLGAP1chr18

4455006

-LRRC23chr12

6992868

+


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Fusion Gene ORF analysis for DLGAP1-LRRC23

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3UTRENST00000315677ENST00000449039DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
5UTR-3UTRENST00000581527ENST00000449039DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
5UTR-5UTRENST00000315677ENST00000433346DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
5UTR-5UTRENST00000581527ENST00000433346DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
5UTR-intronENST00000315677ENST00000007969DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
5UTR-intronENST00000315677ENST00000323702DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
5UTR-intronENST00000315677ENST00000429740DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
5UTR-intronENST00000315677ENST00000436789DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
5UTR-intronENST00000315677ENST00000443597DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
5UTR-intronENST00000581527ENST00000007969DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
5UTR-intronENST00000581527ENST00000323702DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
5UTR-intronENST00000581527ENST00000429740DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
5UTR-intronENST00000581527ENST00000436789DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
5UTR-intronENST00000581527ENST00000443597DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-3UTRENST00000400145ENST00000449039DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-3UTRENST00000400147ENST00000449039DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-3UTRENST00000400149ENST00000449039DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-3UTRENST00000400150ENST00000449039DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-3UTRENST00000400155ENST00000449039DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-3UTRENST00000478161ENST00000449039DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-3UTRENST00000515196ENST00000449039DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-3UTRENST00000534970ENST00000449039DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-3UTRENST00000539435ENST00000449039DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-3UTRENST00000581699ENST00000449039DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-3UTRENST00000584874ENST00000449039DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-5UTRENST00000400145ENST00000433346DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-5UTRENST00000400147ENST00000433346DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-5UTRENST00000400149ENST00000433346DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-5UTRENST00000400150ENST00000433346DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-5UTRENST00000400155ENST00000433346DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-5UTRENST00000478161ENST00000433346DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-5UTRENST00000515196ENST00000433346DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-5UTRENST00000534970ENST00000433346DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-5UTRENST00000539435ENST00000433346DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-5UTRENST00000581699ENST00000433346DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-5UTRENST00000584874ENST00000433346DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000400145ENST00000007969DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000400145ENST00000323702DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000400145ENST00000429740DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000400145ENST00000436789DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000400145ENST00000443597DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000400147ENST00000007969DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000400147ENST00000323702DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000400147ENST00000429740DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000400147ENST00000436789DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000400147ENST00000443597DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000400149ENST00000007969DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000400149ENST00000323702DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000400149ENST00000429740DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000400149ENST00000436789DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000400149ENST00000443597DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000400150ENST00000007969DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000400150ENST00000323702DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000400150ENST00000429740DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000400150ENST00000436789DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000400150ENST00000443597DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000400155ENST00000007969DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000400155ENST00000323702DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000400155ENST00000429740DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000400155ENST00000436789DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000400155ENST00000443597DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000478161ENST00000007969DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000478161ENST00000323702DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000478161ENST00000429740DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000478161ENST00000436789DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000478161ENST00000443597DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000515196ENST00000007969DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000515196ENST00000323702DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000515196ENST00000429740DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000515196ENST00000436789DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000515196ENST00000443597DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000534970ENST00000007969DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000534970ENST00000323702DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000534970ENST00000429740DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000534970ENST00000436789DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000534970ENST00000443597DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000539435ENST00000007969DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000539435ENST00000323702DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000539435ENST00000429740DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000539435ENST00000436789DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000539435ENST00000443597DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000581699ENST00000007969DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000581699ENST00000323702DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000581699ENST00000429740DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000581699ENST00000436789DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000581699ENST00000443597DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000584874ENST00000007969DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000584874ENST00000323702DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000584874ENST00000429740DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000584874ENST00000436789DLGAP1chr18

4455006

-LRRC23chr12

6992868

+
intron-intronENST00000584874ENST00000443597DLGAP1chr18

4455006

-LRRC23chr12

6992868

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DLGAP1-LRRC23


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DLGAP1chr184455005-LRRC23chr126992867+2.68E-060.99999726
DLGAP1chr184455005-LRRC23chr126992867+2.68E-060.99999726
DLGAP1chr184455005-LRRC23chr126992867+2.68E-060.99999726
DLGAP1chr184455005-LRRC23chr126992867+2.68E-060.99999726


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DLGAP1-LRRC23


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:4455006/:6992868)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DLGAP1-LRRC23


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DLGAP1-LRRC23


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DLGAP1-LRRC23


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DLGAP1-LRRC23


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDLGAP1C0036341Schizophrenia3PSYGENET
HgeneDLGAP1C1535926Neurodevelopmental Disorders1CTD_human