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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CYTH3-SPATA18 (FusionGDB2 ID:HG9265TG132671)

Fusion Gene Summary for CYTH3-SPATA18

check button Fusion gene summary
Fusion gene informationFusion gene name: CYTH3-SPATA18
Fusion gene ID: hg9265tg132671
HgeneTgene
Gene symbol

CYTH3

SPATA18

Gene ID

9265

132671

Gene namecytohesin 3spermatogenesis associated 18
SynonymsARNO3|GRP1|PSCD3|cytohesin-3Mieap|SPETEX1
Cytomap('CYTH3')('SPATA18')

7p22.1

4q12

Type of geneprotein-codingprotein-coding
Descriptioncytohesin-3ARF nucleotide-binding site opener 3PH, SEC7 and coiled-coil domain-containing protein 3general receptor of phosphoinositides 1pleckstrin homology, Sec7 and coiled-coil domains 3mitochondria-eating proteinspermatogenesis associated 18 homologtestis tissue sperm-binding protein Li 71n
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000350796, ENST00000396741, 
ENST00000488964, 
Fusion gene scores* DoF score12 X 10 X 8=9602 X 3 X 2=12
# samples 142
** MAII scorelog2(14/960*10)=-2.77760757866355
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CYTH3 [Title/Abstract] AND SPATA18 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCYTH3(6217454)-SPATA18(52935987), # samples:2
Anticipated loss of major functional domain due to fusion event.CYTH3-SPATA18 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CYTH3-SPATA18 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CYTH3-SPATA18 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CYTH3-SPATA18 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSPATA18

GO:0006974

cellular response to DNA damage stimulus

21264221


check buttonFusion gene breakpoints across CYTH3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SPATA18 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-86-8074-01ACYTH3chr7

6217454

-SPATA18chr4

52935987

+
ChimerDB4LUADTCGA-86-8074-01ACYTH3chr7

6217454

-SPATA18chr4

52938083

+


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Fusion Gene ORF analysis for CYTH3-SPATA18

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000350796ENST00000506829CYTH3chr7

6217454

-SPATA18chr4

52938083

+
5CDS-intronENST00000350796ENST00000419395CYTH3chr7

6217454

-SPATA18chr4

52935987

+
5CDS-intronENST00000350796ENST00000506829CYTH3chr7

6217454

-SPATA18chr4

52935987

+
In-frameENST00000350796ENST00000295213CYTH3chr7

6217454

-SPATA18chr4

52935987

+
In-frameENST00000350796ENST00000295213CYTH3chr7

6217454

-SPATA18chr4

52938083

+
In-frameENST00000350796ENST00000419395CYTH3chr7

6217454

-SPATA18chr4

52938083

+
intron-3CDSENST00000396741ENST00000295213CYTH3chr7

6217454

-SPATA18chr4

52935987

+
intron-3CDSENST00000396741ENST00000295213CYTH3chr7

6217454

-SPATA18chr4

52938083

+
intron-3CDSENST00000396741ENST00000419395CYTH3chr7

6217454

-SPATA18chr4

52938083

+
intron-3CDSENST00000488964ENST00000295213CYTH3chr7

6217454

-SPATA18chr4

52935987

+
intron-3CDSENST00000488964ENST00000295213CYTH3chr7

6217454

-SPATA18chr4

52938083

+
intron-3CDSENST00000488964ENST00000419395CYTH3chr7

6217454

-SPATA18chr4

52938083

+
intron-3UTRENST00000396741ENST00000506829CYTH3chr7

6217454

-SPATA18chr4

52938083

+
intron-3UTRENST00000488964ENST00000506829CYTH3chr7

6217454

-SPATA18chr4

52938083

+
intron-intronENST00000396741ENST00000419395CYTH3chr7

6217454

-SPATA18chr4

52935987

+
intron-intronENST00000396741ENST00000506829CYTH3chr7

6217454

-SPATA18chr4

52935987

+
intron-intronENST00000488964ENST00000419395CYTH3chr7

6217454

-SPATA18chr4

52935987

+
intron-intronENST00000488964ENST00000506829CYTH3chr7

6217454

-SPATA18chr4

52935987

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000350796CYTH3chr76217454-ENST00000295213SPATA18chr452935987+4105505321699555
ENST00000350796CYTH3chr76217454-ENST00000295213SPATA18chr452938083+4009505321603523
ENST00000350796CYTH3chr76217454-ENST00000419395SPATA18chr452938083+2610505321603523

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000350796ENST00000295213CYTH3chr76217454-SPATA18chr452935987+0.0003586560.9996413
ENST00000350796ENST00000295213CYTH3chr76217454-SPATA18chr452938083+0.0002717740.99972826
ENST00000350796ENST00000419395CYTH3chr76217454-SPATA18chr452938083+0.0005928810.9994072

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Fusion Genomic Features for CYTH3-SPATA18


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CYTH3chr76217453-SPATA18chr452938082+0.0029292240.9970708
CYTH3chr76217453-SPATA18chr452935986+0.0007073010.99929273
CYTH3chr76217453-SPATA18chr452938082+0.0029292240.9970708
CYTH3chr76217453-SPATA18chr452935986+0.0007073010.99929273

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CYTH3-SPATA18


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:6217454/chr4:52935987)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCYTH3chr7:6217454chr4:52935987ENST00000350796-51314_61122400.0Coiled coilOntology_term=ECO:0000255
HgeneCYTH3chr7:6217454chr4:52938083ENST00000350796-51314_61122400.0Coiled coilOntology_term=ECO:0000255
TgeneSPATA18chr7:6217454chr4:52935987ENST00000295213313219_256140539.0Coiled coilOntology_term=ECO:0000255
TgeneSPATA18chr7:6217454chr4:52935987ENST00000419395012118_1870507.0Coiled coilOntology_term=ECO:0000255
TgeneSPATA18chr7:6217454chr4:52935987ENST00000419395012219_2560507.0Coiled coilOntology_term=ECO:0000255
TgeneSPATA18chr7:6217454chr4:52938083ENST00000295213413219_256172539.0Coiled coilOntology_term=ECO:0000255
TgeneSPATA18chr7:6217454chr4:52938083ENST00000419395312219_256140507.0Coiled coilOntology_term=ECO:0000255
TgeneSPATA18chr7:6217454chr4:52935987ENST00000295213313257_313140539.0Compositional biasNote=Ser-rich
TgeneSPATA18chr7:6217454chr4:52935987ENST00000419395012257_3130507.0Compositional biasNote=Ser-rich
TgeneSPATA18chr7:6217454chr4:52938083ENST00000295213413257_313172539.0Compositional biasNote=Ser-rich
TgeneSPATA18chr7:6217454chr4:52938083ENST00000419395312257_313140507.0Compositional biasNote=Ser-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCYTH3chr7:6217454chr4:52935987ENST00000350796-513264_381122400.0DomainPH
HgeneCYTH3chr7:6217454chr4:52935987ENST00000350796-51377_206122400.0DomainSEC7
HgeneCYTH3chr7:6217454chr4:52938083ENST00000350796-513264_381122400.0DomainPH
HgeneCYTH3chr7:6217454chr4:52938083ENST00000350796-51377_206122400.0DomainSEC7
HgeneCYTH3chr7:6217454chr4:52935987ENST00000350796-513273_281122400.0RegionNote=Phosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneCYTH3chr7:6217454chr4:52935987ENST00000350796-513392_400122400.0RegionC-terminal autoinhibitory region
HgeneCYTH3chr7:6217454chr4:52938083ENST00000350796-513273_281122400.0RegionNote=Phosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneCYTH3chr7:6217454chr4:52938083ENST00000350796-513392_400122400.0RegionC-terminal autoinhibitory region
TgeneSPATA18chr7:6217454chr4:52935987ENST00000295213313118_187140539.0Coiled coilOntology_term=ECO:0000255
TgeneSPATA18chr7:6217454chr4:52938083ENST00000295213413118_187172539.0Coiled coilOntology_term=ECO:0000255
TgeneSPATA18chr7:6217454chr4:52938083ENST00000419395312118_187140507.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for CYTH3-SPATA18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>21165_21165_1_CYTH3-SPATA18_CYTH3_chr7_6217454_ENST00000350796_SPATA18_chr4_52935987_ENST00000295213_length(transcript)=4105nt_BP=505nt
GGAGGAGGCCCGGCCGCGACCCGGGCCGCGCGCTGAGGAGCCGCCCGGTCGCCTGCGCGCTCCCTCCGGCGGCGTCCCCAGCCCGCGGCC
CCTCTGCTGCCGGCCCCCGGCTCGCCGGCTGCGGGAGTGGCCTCAAGATGGATGAAGACGGCGGCGGCGAGGGTGGTGGCGTGCCTGAAG
ACCTCTCATTAGAAGAGAGAGAAGAACTTCTAGACATTCGTCGAAGAAAAAAGGAACTTATTGATGACATTGAGAGGCTGAAATATGAAA
TTGCAGAGGTGATGACAGAGATCGACAATCTAACTTCCGTAGAGGAGAGCAAAACGACTCAGAGGAACAAACAGATAGCCATGGGAAGAA
AGAAATTCAACATGGATCCCAAAAAGGGAATTCAGTTTCTAATAGAAAATGACCTGCTACAGAGTTCCCCAGAAGACGTCGCCCAGTTCC
TTTATAAAGGAGAAGGCCTAAATAAGACCGTCATTGGGGACTACCTGGGTGAAAGTCTGGTTGAAACTGAAAAGAATCTTGAAGAAAGCA
AGAACAGATCGGCCATATCCCTTTTGGCTGCAGAGGAGGAAATAAATCAGCTGAAAAAGCAGCTTAAATCTCTTCAAGCTCAGGAGGATG
CCCGCCACAGAAACACAGATCAGAGGAGCTCAGAGAATAGGCGGTCAGAGCCTTGGAGCTTGGAGGAGCGGAAGCGTGAGCAGTGGAACT
CACTCAAGCAGAATGCAGACCAGCAGGACACAGAAGCCATGTCCGATTATAAGAAACAGCTCCGAAACCTGAAGGAGGAGATAGCTGTTC
TGTCTGCTGAGAAAAGTGCACTCCAAGGAAGGTCCTCCAGGAGCCGGTCTCCCAGCCCTGCCCCTCGCAGCCGTAGCTGCAGCCGCAGCA
GATCTGCCAGCCCCTCCACCGCTGTCAAGGTCAGGAGACCGTCCCCAAACCGCTCCAAGCTGTCCAATGTGGCGCGCAAGGCTGCCCTCT
TGTCCCGGTTCAGCGATTCCTATTCCCAGGCCCGCCTGGACGCGCAGTGCCTGCTGCGGCGCTGCATCGACAAGGCTGAGACCGTTCAGC
GGATCATCTACATCGCCACAGTGGAGGCATTCCATGTAGCAAAAATGGCATTCAGACACTTCAAGATCCATGTGAGAAAATCGTTGACAC
CATCTTATGTGGGGTCGAATGACTTTGAGAATGCTGTCTTGGATTATGTCATTTGTCATCTTGATCTATATGATTCTCAAAGCAGTGTCA
ATGATGTGATCCGAGCCATGAATGTCAATCCCAAGATTTCATTCCCTCCTGTCGTTGACTTTTGCCTTCTCAGTGACTTCATCCAGGAGA
TATGTTGCATTGCCTTTGCAATGCAGGCCTTAGAACCACCCCTAGATATTGCATATGGAGCAGATGGAGAAGTTTTTAATGATTGCAAAT
ACCGCCGCAGCTACGACTCGGATTTCACTGCTCCCTTAGTCCTCTATCACGTGTGGCCTGCTCTCATGGAGAATGACTGTGTCATTATGA
AGGGAGAAGCTGTCACCAGGAGAGGGGCTTTTTGGAATTCGGTGCGATCTGTAAGTCGTTGTCGAAGCAGGAGTTTAAGTCCCATTTGCC
CCCGTAGCCAAATTGGTTTAAACACGATGTCTCGAAGTCGGAGTCCTTCTCCAATAAGATGTGGATTGCCAAGATTTTAAAAGCACCAGA
CCTGCTCCTTTGACCCAGTGCGTGGAAACAGCTGCTTTCTCCAGTGCCGCCATCTGTCTTCTGTGTCTGCCTCAGACCTCACTTAAGATA
ATGTCAAAAGGCAATTCTGTGTATCACCCCACACAGAGAGTTAAATGTTTTGGCTTGGCGCATTTGTAACTTTAGATATATTGCATTCTA
TTTTATTTTATAGATACTAATTCCATTAATTTCATAAAAATGATTGTATAGGCATTTAGGATCATATTCATTCGAAGCAAAGTCCGTTAC
AAAGGTTCAAGATTTCCATCTCAAAACACTACGCTCTTTTATGGGAACTGTGTGAACTGAAGTGGAAAGCATCTACCATGCTGAGGCTAA
AAGAAAAGATGAATCATTTTAGTTTGCAGATGGATCGTAAATATAATTGTTGGTATCAGCTTTAGCTCAAAACCAATATTAGGTGTTTTA
ATTTCCTTTTAAGGTTTGGAAGACAGCCCTAATCTCAGGTTGGGGAGCTCATGTTAGTAGCAGTGACTTAAGGCTAAGTGTAGAAGATAA
TTTAAGATACATTTTCTTTATATATTAGCCAACAAATTATATTTATTGGTTGGCTTGCTTTTCCGTTCTGATTTTGAGAGTGCCCAGTTT
GGTTTAGTTGACCAATGAATGTCAAAGCTACTTAGTTGAGAGAATTTCCTTGTTCATAAATGTAGAGCAGTGATTTGATTAGAAGCCAGC
TTTGAGATAAATGTTAATTACCTCATGCATATCTCCTGGGAATATTTCAAACTGTTTTAATGCATGTGTTATATATAAAAGTTTCTTGGG
ACATGCTCTTCACCTGTTCTACCTAGTTATTTGCAAATTCAGACCTCCTATTGAACTCTGTCTGACCAAAACTACTTAAACTCAAGGCCC
AAAACTAGGGGCACCATTTACTGATTTTAAATTGAGTATATATCCCTTGACTTCTTCACTGTCAAATACTTTTGAAACTTCACGTTCAAG
ATAAGAATGGAATGTTGCTTTCTTGCAATAAGTAATGTTCTTTCTGCCTTTTTTTCACTTTTAAGTCAGCCTTAAACACATGCCTCACAA
ACATCTACTTTCTCCACATACCTTTGAGAGAGACACTGAATTGGCCTCAGCTCAGTTTTGCATAAGCTTAGTGCCAGAACCAGCACCTGA
TGCTTTTCAGGTGAAAATAAAACAAACAGCTTCTCTAAAGCATCTTACCCCTGTGCTGGAGGTTTGAGGGACCTCTTCAGTGCCTGCCCC
TTGAGTCTAATGGTCACCACCTCATTCTGAAGTATGAGTTGAATTTTTTGCCCTCTTTGCATATTTACATTAGTCATCACTTTGAAGCAA
TGCAGTGTGCTGGAAGGAGCACTATCTGCCTAGGTAACTGCTAGTCATGACTTGGTCATCAGCTTGCTTTGTGGCACTGAGCAAGTTACT
TCACTTCTCTGAGCCTTGGTTTTATCATAGGGTGAGGAGGTTGGATACAATTAGTGCCCCTCTTAACCCTGCAGACTCAATGTTCCCTTT
TATAACAAGTATTTTATTCTGAATATGAAATGAAAATTAAAGTTAATATAATCATCTATGTGCATGTATAATTTTAAGCAGTGAACATAG
TACCCTAACTATAATATAAAGCAGAAAAAAAGGCAACTTTTAATAAAATAAAATGTATTTCAATAAAAAAGCTTGGGTATAACCACCCTA
GAAGATAAAATTAAGTCATTAGATGGCTGAACCTGCATGTAGAGCCACCAGCTACAAATGAAAATCAATGTGTGTATTGGCAACAGAAAA
TCACGGTGTTGTCATTGGATGTGACTTTCTGAAGTGGTGGGCAATTCTTGTTAATGTTTTAAACAAAAAAAAAAAAACCTTACAGTCTTG
CCCTGATTTACACAGCAGTCACATTCCTGGAAAATTCAAGTGTTTATTAAAACTATGCAACAGTTACTGTGTGTTATACGTTGAAAGGTC
TTCACTAATATCTCACTAAGTAATGAGAATGCCTACATATCAGAATTTTTTTTTTCAGGAGCCAAGCACATATACTGATTTGGAAAAAGG
CACAGGTAGCTCAGTTTATTTGCTTTCTACCCTGCCTGGCCACTTGCTGTTTCTTCAGTTTCTAATTTGAGCTGTAACTACACAAGGAAA
GCTAAATAGTCTGGAAAATTTTTGGAAAGAATCCACAAAGCCAAAGGAGACTGGCCTATACTCATTTTATCTGGGGATGTACCTTACCCT
TAGAGACTTTGAAAAATGTGAAGCTCTTATTTTGTAACCTGGGTAAATGTTAGTTTCTAGATTTTCGGCTTAACATCTAATAATAACATT
TAAAAAGTGCTTTTGTAACTATTAGTTATTTGCAATAAAATGCTTTCCTTCTACA

>21165_21165_1_CYTH3-SPATA18_CYTH3_chr7_6217454_ENST00000350796_SPATA18_chr4_52935987_ENST00000295213_length(amino acids)=555AA_BP=157
MRSRPVACALPPAASPARGPSAAGPRLAGCGSGLKMDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNL
TSVEESKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGESLVETEKNLEESKNRSAISLLAA
EEEINQLKKQLKSLQAQEDARHRNTDQRSSENRRSEPWSLEERKREQWNSLKQNADQQDTEAMSDYKKQLRNLKEEIAVLSAEKSALQGR
SSRSRSPSPAPRSRSCSRSRSASPSTAVKVRRPSPNRSKLSNVARKAALLSRFSDSYSQARLDAQCLLRRCIDKAETVQRIIYIATVEAF
HVAKMAFRHFKIHVRKSLTPSYVGSNDFENAVLDYVICHLDLYDSQSSVNDVIRAMNVNPKISFPPVVDFCLLSDFIQEICCIAFAMQAL
EPPLDIAYGADGEVFNDCKYRRSYDSDFTAPLVLYHVWPALMENDCVIMKGEAVTRRGAFWNSVRSVSRCRSRSLSPICPRSQIGLNTMS
RSRSPSPIRCGLPRF

--------------------------------------------------------------
>21165_21165_2_CYTH3-SPATA18_CYTH3_chr7_6217454_ENST00000350796_SPATA18_chr4_52938083_ENST00000295213_length(transcript)=4009nt_BP=505nt
GGAGGAGGCCCGGCCGCGACCCGGGCCGCGCGCTGAGGAGCCGCCCGGTCGCCTGCGCGCTCCCTCCGGCGGCGTCCCCAGCCCGCGGCC
CCTCTGCTGCCGGCCCCCGGCTCGCCGGCTGCGGGAGTGGCCTCAAGATGGATGAAGACGGCGGCGGCGAGGGTGGTGGCGTGCCTGAAG
ACCTCTCATTAGAAGAGAGAGAAGAACTTCTAGACATTCGTCGAAGAAAAAAGGAACTTATTGATGACATTGAGAGGCTGAAATATGAAA
TTGCAGAGGTGATGACAGAGATCGACAATCTAACTTCCGTAGAGGAGAGCAAAACGACTCAGAGGAACAAACAGATAGCCATGGGAAGAA
AGAAATTCAACATGGATCCCAAAAAGGGAATTCAGTTTCTAATAGAAAATGACCTGCTACAGAGTTCCCCAGAAGACGTCGCCCAGTTCC
TTTATAAAGGAGAAGGCCTAAATAAGACCGTCATTGGGGACTACCTGGGTGAAAGGCTTAAATCTCTTCAAGCTCAGGAGGATGCCCGCC
ACAGAAACACAGATCAGAGGAGCTCAGAGAATAGGCGGTCAGAGCCTTGGAGCTTGGAGGAGCGGAAGCGTGAGCAGTGGAACTCACTCA
AGCAGAATGCAGACCAGCAGGACACAGAAGCCATGTCCGATTATAAGAAACAGCTCCGAAACCTGAAGGAGGAGATAGCTGTTCTGTCTG
CTGAGAAAAGTGCACTCCAAGGAAGGTCCTCCAGGAGCCGGTCTCCCAGCCCTGCCCCTCGCAGCCGTAGCTGCAGCCGCAGCAGATCTG
CCAGCCCCTCCACCGCTGTCAAGGTCAGGAGACCGTCCCCAAACCGCTCCAAGCTGTCCAATGTGGCGCGCAAGGCTGCCCTCTTGTCCC
GGTTCAGCGATTCCTATTCCCAGGCCCGCCTGGACGCGCAGTGCCTGCTGCGGCGCTGCATCGACAAGGCTGAGACCGTTCAGCGGATCA
TCTACATCGCCACAGTGGAGGCATTCCATGTAGCAAAAATGGCATTCAGACACTTCAAGATCCATGTGAGAAAATCGTTGACACCATCTT
ATGTGGGGTCGAATGACTTTGAGAATGCTGTCTTGGATTATGTCATTTGTCATCTTGATCTATATGATTCTCAAAGCAGTGTCAATGATG
TGATCCGAGCCATGAATGTCAATCCCAAGATTTCATTCCCTCCTGTCGTTGACTTTTGCCTTCTCAGTGACTTCATCCAGGAGATATGTT
GCATTGCCTTTGCAATGCAGGCCTTAGAACCACCCCTAGATATTGCATATGGAGCAGATGGAGAAGTTTTTAATGATTGCAAATACCGCC
GCAGCTACGACTCGGATTTCACTGCTCCCTTAGTCCTCTATCACGTGTGGCCTGCTCTCATGGAGAATGACTGTGTCATTATGAAGGGAG
AAGCTGTCACCAGGAGAGGGGCTTTTTGGAATTCGGTGCGATCTGTAAGTCGTTGTCGAAGCAGGAGTTTAAGTCCCATTTGCCCCCGTA
GCCAAATTGGTTTAAACACGATGTCTCGAAGTCGGAGTCCTTCTCCAATAAGATGTGGATTGCCAAGATTTTAAAAGCACCAGACCTGCT
CCTTTGACCCAGTGCGTGGAAACAGCTGCTTTCTCCAGTGCCGCCATCTGTCTTCTGTGTCTGCCTCAGACCTCACTTAAGATAATGTCA
AAAGGCAATTCTGTGTATCACCCCACACAGAGAGTTAAATGTTTTGGCTTGGCGCATTTGTAACTTTAGATATATTGCATTCTATTTTAT
TTTATAGATACTAATTCCATTAATTTCATAAAAATGATTGTATAGGCATTTAGGATCATATTCATTCGAAGCAAAGTCCGTTACAAAGGT
TCAAGATTTCCATCTCAAAACACTACGCTCTTTTATGGGAACTGTGTGAACTGAAGTGGAAAGCATCTACCATGCTGAGGCTAAAAGAAA
AGATGAATCATTTTAGTTTGCAGATGGATCGTAAATATAATTGTTGGTATCAGCTTTAGCTCAAAACCAATATTAGGTGTTTTAATTTCC
TTTTAAGGTTTGGAAGACAGCCCTAATCTCAGGTTGGGGAGCTCATGTTAGTAGCAGTGACTTAAGGCTAAGTGTAGAAGATAATTTAAG
ATACATTTTCTTTATATATTAGCCAACAAATTATATTTATTGGTTGGCTTGCTTTTCCGTTCTGATTTTGAGAGTGCCCAGTTTGGTTTA
GTTGACCAATGAATGTCAAAGCTACTTAGTTGAGAGAATTTCCTTGTTCATAAATGTAGAGCAGTGATTTGATTAGAAGCCAGCTTTGAG
ATAAATGTTAATTACCTCATGCATATCTCCTGGGAATATTTCAAACTGTTTTAATGCATGTGTTATATATAAAAGTTTCTTGGGACATGC
TCTTCACCTGTTCTACCTAGTTATTTGCAAATTCAGACCTCCTATTGAACTCTGTCTGACCAAAACTACTTAAACTCAAGGCCCAAAACT
AGGGGCACCATTTACTGATTTTAAATTGAGTATATATCCCTTGACTTCTTCACTGTCAAATACTTTTGAAACTTCACGTTCAAGATAAGA
ATGGAATGTTGCTTTCTTGCAATAAGTAATGTTCTTTCTGCCTTTTTTTCACTTTTAAGTCAGCCTTAAACACATGCCTCACAAACATCT
ACTTTCTCCACATACCTTTGAGAGAGACACTGAATTGGCCTCAGCTCAGTTTTGCATAAGCTTAGTGCCAGAACCAGCACCTGATGCTTT
TCAGGTGAAAATAAAACAAACAGCTTCTCTAAAGCATCTTACCCCTGTGCTGGAGGTTTGAGGGACCTCTTCAGTGCCTGCCCCTTGAGT
CTAATGGTCACCACCTCATTCTGAAGTATGAGTTGAATTTTTTGCCCTCTTTGCATATTTACATTAGTCATCACTTTGAAGCAATGCAGT
GTGCTGGAAGGAGCACTATCTGCCTAGGTAACTGCTAGTCATGACTTGGTCATCAGCTTGCTTTGTGGCACTGAGCAAGTTACTTCACTT
CTCTGAGCCTTGGTTTTATCATAGGGTGAGGAGGTTGGATACAATTAGTGCCCCTCTTAACCCTGCAGACTCAATGTTCCCTTTTATAAC
AAGTATTTTATTCTGAATATGAAATGAAAATTAAAGTTAATATAATCATCTATGTGCATGTATAATTTTAAGCAGTGAACATAGTACCCT
AACTATAATATAAAGCAGAAAAAAAGGCAACTTTTAATAAAATAAAATGTATTTCAATAAAAAAGCTTGGGTATAACCACCCTAGAAGAT
AAAATTAAGTCATTAGATGGCTGAACCTGCATGTAGAGCCACCAGCTACAAATGAAAATCAATGTGTGTATTGGCAACAGAAAATCACGG
TGTTGTCATTGGATGTGACTTTCTGAAGTGGTGGGCAATTCTTGTTAATGTTTTAAACAAAAAAAAAAAAACCTTACAGTCTTGCCCTGA
TTTACACAGCAGTCACATTCCTGGAAAATTCAAGTGTTTATTAAAACTATGCAACAGTTACTGTGTGTTATACGTTGAAAGGTCTTCACT
AATATCTCACTAAGTAATGAGAATGCCTACATATCAGAATTTTTTTTTTCAGGAGCCAAGCACATATACTGATTTGGAAAAAGGCACAGG
TAGCTCAGTTTATTTGCTTTCTACCCTGCCTGGCCACTTGCTGTTTCTTCAGTTTCTAATTTGAGCTGTAACTACACAAGGAAAGCTAAA
TAGTCTGGAAAATTTTTGGAAAGAATCCACAAAGCCAAAGGAGACTGGCCTATACTCATTTTATCTGGGGATGTACCTTACCCTTAGAGA
CTTTGAAAAATGTGAAGCTCTTATTTTGTAACCTGGGTAAATGTTAGTTTCTAGATTTTCGGCTTAACATCTAATAATAACATTTAAAAA
GTGCTTTTGTAACTATTAGTTATTTGCAATAAAATGCTTTCCTTCTACA

>21165_21165_2_CYTH3-SPATA18_CYTH3_chr7_6217454_ENST00000350796_SPATA18_chr4_52938083_ENST00000295213_length(amino acids)=523AA_BP=157
MRSRPVACALPPAASPARGPSAAGPRLAGCGSGLKMDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNL
TSVEESKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERLKSLQAQEDARHRNTDQRSSEN
RRSEPWSLEERKREQWNSLKQNADQQDTEAMSDYKKQLRNLKEEIAVLSAEKSALQGRSSRSRSPSPAPRSRSCSRSRSASPSTAVKVRR
PSPNRSKLSNVARKAALLSRFSDSYSQARLDAQCLLRRCIDKAETVQRIIYIATVEAFHVAKMAFRHFKIHVRKSLTPSYVGSNDFENAV
LDYVICHLDLYDSQSSVNDVIRAMNVNPKISFPPVVDFCLLSDFIQEICCIAFAMQALEPPLDIAYGADGEVFNDCKYRRSYDSDFTAPL
VLYHVWPALMENDCVIMKGEAVTRRGAFWNSVRSVSRCRSRSLSPICPRSQIGLNTMSRSRSPSPIRCGLPRF

--------------------------------------------------------------
>21165_21165_3_CYTH3-SPATA18_CYTH3_chr7_6217454_ENST00000350796_SPATA18_chr4_52938083_ENST00000419395_length(transcript)=2610nt_BP=505nt
GGAGGAGGCCCGGCCGCGACCCGGGCCGCGCGCTGAGGAGCCGCCCGGTCGCCTGCGCGCTCCCTCCGGCGGCGTCCCCAGCCCGCGGCC
CCTCTGCTGCCGGCCCCCGGCTCGCCGGCTGCGGGAGTGGCCTCAAGATGGATGAAGACGGCGGCGGCGAGGGTGGTGGCGTGCCTGAAG
ACCTCTCATTAGAAGAGAGAGAAGAACTTCTAGACATTCGTCGAAGAAAAAAGGAACTTATTGATGACATTGAGAGGCTGAAATATGAAA
TTGCAGAGGTGATGACAGAGATCGACAATCTAACTTCCGTAGAGGAGAGCAAAACGACTCAGAGGAACAAACAGATAGCCATGGGAAGAA
AGAAATTCAACATGGATCCCAAAAAGGGAATTCAGTTTCTAATAGAAAATGACCTGCTACAGAGTTCCCCAGAAGACGTCGCCCAGTTCC
TTTATAAAGGAGAAGGCCTAAATAAGACCGTCATTGGGGACTACCTGGGTGAAAGGCTTAAATCTCTTCAAGCTCAGGAGGATGCCCGCC
ACAGAAACACAGATCAGAGGAGCTCAGAGAATAGGCGGTCAGAGCCTTGGAGCTTGGAGGAGCGGAAGCGTGAGCAGTGGAACTCACTCA
AGCAGAATGCAGACCAGCAGGACACAGAAGCCATGTCCGATTATAAGAAACAGCTCCGAAACCTGAAGGAGGAGATAGCTGTTCTGTCTG
CTGAGAAAAGTGCACTCCAAGGAAGGTCCTCCAGGAGCCGGTCTCCCAGCCCTGCCCCTCGCAGCCGTAGCTGCAGCCGCAGCAGATCTG
CCAGCCCCTCCACCGCTGTCAAGGTCAGGAGACCGTCCCCAAACCGCTCCAAGCTGTCCAATGTGGCGCGCAAGGCTGCCCTCTTGTCCC
GGTTCAGCGATTCCTATTCCCAGGCCCGCCTGGACGCGCAGTGCCTGCTGCGGCGCTGCATCGACAAGGCTGAGACCGTTCAGCGGATCA
TCTACATCGCCACAGTGGAGGCATTCCATGTAGCAAAAATGGCATTCAGACACTTCAAGATCCATGTGAGAAAATCGTTGACACCATCTT
ATGTGGGGTCGAATGACTTTGAGAATGCTGTCTTGGATTATGTCATTTGTCATCTTGATCTATATGATTCTCAAAGCAGTGTCAATGATG
TGATCCGAGCCATGAATGTCAATCCCAAGATTTCATTCCCTCCTGTCGTTGACTTTTGCCTTCTCAGTGACTTCATCCAGGAGATATGTT
GCATTGCCTTTGCAATGCAGGCCTTAGAACCACCCCTAGATATTGCATATGGAGCAGATGGAGAAGTTTTTAATGATTGCAAATACCGCC
GCAGCTACGACTCGGATTTCACTGCTCCCTTAGTCCTCTATCACGTGTGGCCTGCTCTCATGGAGAATGACTGTGTCATTATGAAGGGAG
AAGCTGTCACCAGGAGAGGGGCTTTTTGGAATTCGGTGCGATCTGTAAGTCGTTGTCGAAGCAGGAGTTTAAGTCCCATTTGCCCCCGTA
GCCAAATTGGTTTAAACACGATGTCTCGAAGTCGGAGTCCTTCTCCAATAAGATGTGGATTGCCAAGATTTTAAAAGCACCAGACCTGCT
CCTTTGACCCAGTGCGTGGAAACAGCTGCTTTCTCCAGTGCCGCCATCTGTCTTCTGTGTCTGCCTCAGACCTCACTTAAGATAATGTCA
AAAGGCAATTCTGTGTATCACCCCACACAGAGAGTTAAATGTTTTGGCTTGGCGCATTTGTAACTTTAGATATATTGCATTCTATTTTAT
TTTATAGATACTAATTCCATTAATTTCATAAAAATGATTGTATAGGCATTTAGGATCATATTCATTCGAAGCAAAGTCCGTTACAAAGGT
TCAAGATTTCCATCTCAAAACACTACGCTCTTTTATGGGAACTGTGTGAACTGAAGTGGAAAGCATCTACCATGCTGAGGCTAAAAGAAA
AGATGAATCATTTTAGTTTGCAGATGGATCGTAAATATAATTGTTGGTATCAGCTTTAGCTCAAAACCAATATTAGGTGTTTTAATTTCC
TTTTAAGGTTTGGAAGACAGCCCTAATCTCAGGTTGGGGAGCTCATGTTAGTAGCAGTGACTTAAGGCTAAGTGTAGAAGATAATTTAAG
ATACATTTTCTTTATATATTAGCCAACAAATTATATTTATTGGTTGGCTTGCTTTTCCGTTCTGATTTTGAGAGTGCCCAGTTTGGTTTA
GTTGACCAATGAATGTCAAAGCTACTTAGTTGAGAGAATTTCCTTGTTCATAAATGTAGAGCAGTGATTTGATTAGAAGCCAGCTTTGAG
ATAAATGTTAATTACCTCATGCATATCTCCTGGGAATATTTCAAACTGTTTTAATGCATGTGTTATATATAAAAGTTTCTTGGGACATGC
TCTTCACCTGTTCTACCTAGTTATTTGCAAATTCAGACCTCCTATTGAACTCTGTCTGACCAAAACTACTTAAACTCAAGGCCCAAAACT
AGGGGCACCATTTACTGATTTTAAATTGAGTATATATCCCTTGACTTCTTCACTGTCAAATACTTTTGAAACTTCACGTTCAAGATAAGA


>21165_21165_3_CYTH3-SPATA18_CYTH3_chr7_6217454_ENST00000350796_SPATA18_chr4_52938083_ENST00000419395_length(amino acids)=523AA_BP=157
MRSRPVACALPPAASPARGPSAAGPRLAGCGSGLKMDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNL
TSVEESKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERLKSLQAQEDARHRNTDQRSSEN
RRSEPWSLEERKREQWNSLKQNADQQDTEAMSDYKKQLRNLKEEIAVLSAEKSALQGRSSRSRSPSPAPRSRSCSRSRSASPSTAVKVRR
PSPNRSKLSNVARKAALLSRFSDSYSQARLDAQCLLRRCIDKAETVQRIIYIATVEAFHVAKMAFRHFKIHVRKSLTPSYVGSNDFENAV
LDYVICHLDLYDSQSSVNDVIRAMNVNPKISFPPVVDFCLLSDFIQEICCIAFAMQALEPPLDIAYGADGEVFNDCKYRRSYDSDFTAPL
VLYHVWPALMENDCVIMKGEAVTRRGAFWNSVRSVSRCRSRSLSPICPRSQIGLNTMSRSRSPSPIRCGLPRF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CYTH3-SPATA18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CYTH3-SPATA18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CYTH3-SPATA18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0376358Malignant neoplasm of prostate1CTD_human
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC4704874Mammary Carcinoma, Human1CTD_human